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Epidemiol Health 2022 Jun 21:e2022053. Epub 2022 Jun 21.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

Objectives: The COVID-19 pandemic has affected the utilization of healthcare services, such as participation in cancer screening programs. We compared cancer screening participation rates for colorectal, gastric, breast, and cervical cancers among participants in the National Cancer Screening Program (NCSP) in 2019 and 2020 to address the potential distraction effect of COVID-19 on cancer screening.

Methods: Data from the NCSP for four cancer types (stomach, colorectal, breast and cervical) in 2019 and 2020 were used to calculate cancer screening participation rates by calendar month, gender, age group, and geographical region. Read More

Acta Cytol 2022 Jun 27:1-11. Epub 2022 Jun 27.

Division of Cytopathology, ICMR-National Institute of Cancer Prevention and Research, Noida, India.

Introduction: Women living with HIV (WLHIV) are at an increased risk of developing cervical precancerous lesions and cervical human papillomavirus (HPV) infection. This study aimed at evaluating the prevalence of cervical lesions and high-risk HPV (HR-HPV) infection in WLHIV in comparison to the HIV-negative women undergoing opportunistic screening. In addition, these findings among WLHIV were correlated with the clinic-demographic factors. Read More

Phys Med 2022 Jun 24;100:81-89. Epub 2022 Jun 24.

School of Mechanical Engineering, Tianjin University, Tianjin 300350, China.

Purpose: Interstitial needles placement is a critical component of combined intracavitary/interstitial (IC/IS) brachytherapy (BT). To ensure precise placement of interstitial needles, we proposed a novel ultrasonic (US) probe calibration method to accurately register the US image in the magnetic resonance imaging (MRI) image and provide multimodal image guidance for needle placement.

Methods: A wire-based calibration phantom combined with the stylus was developed for the calibration of US probe. Read More

Rev Med Inst Mex Seguro Soc 2022 Mar 1;60(2):164-170. Epub 2022 Mar 1.

Instituto Mexicano del Seguro Social, Coordinación Auxiliar Médica de Investigación, Servicio de Colposcopía. La Paz, Baja California Sur, México.

Background: Despite the fact that the Papanicolaou technique is the most effective method of prevention and detection of cervical cancer, the precision of this tool remains controversial; Because of this, there are medical and scientific efforts to improve the quality of the procedure.

Objective: Compare the quality of sampling between the conventional and modified technique.

Material And Methods: Descriptive and comparative observational study in 150 cervical cytology samples (75 conventional technique samples and 75 in modified technique) in women aged 25 to 64 years. Read More

JMIR Mhealth Uhealth 2022 Jun 27;10(6):e32089. Epub 2022 Jun 27.

Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Background: Despite the availability and accessibility of free Papanicolaou (Pap) smear as a screening tool for cervical cancer, the uptake of Pap smear in Malaysia has not changed in the last 15 years. Previous studies have shown that the high uptake of Pap smear reduces the mortality rate of patients with cervical cancer. The low uptake of Pap smear is multifactorial, and the problem could be minimized through the use of mobile technologies. Read More

Immun Inflamm Dis 2022 Jul;10(7):e645

Laboratory Microorganismes and Active Biomolecules, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Objectives: Human leukocyte antigen-G (HLA-G) is implicated in several cancers and is considered to be an immune checkpoint regulator. We determined the association between polymorphisms in the 3' untranslated region of HLA-G and soluble HLA-G (sHLA-G) expression with gynecological cancers (GCs).

Methods: A meta-analysis was conducted to examine the association between HLA-G14-bp insertion (I)/deletion (D) and +3142C/G polymorphism in GC and to evaluate sHLA-G expression RESULTS: We revealed a significant association between the +3142C/G polymorphism and invasive cervical cancer (ICC) based on the allelic model G versus C (odds ratio [OR] = 0. Read More

J Prev (2022) 2022 Jun 27. Epub 2022 Jun 27.

Epidemiology, School of Public Health, Loma Linda University, 24951 North Circle Drive, Nichol Hall #2008, Loma Linda, CA, 92350, USA.

Cervical cancer is preventable and treatable through regular screening and follow-up. However, the utilization of cervical cancer screening may vary widely based on individual lifestyles. The purpose of this study was to examine the differences in the adherence to cervical cancer screening guidelines in various dietary groups. Read More

Future Oncol 2022 Jun 27. Epub 2022 Jun 27.

Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

To explore the appropriate triage methods for women infected with high-risk human papillomavirus (hrHPV). A total of 424 out of 872 hrHPV-infected women were divided into cervicitis (n = 123), cervical intraepithelial neoplasia grade 1 (CIN1; n = 89), CIN2 (n = 72), CIN3 (n = 87) and cervical cancer (n = 53) groups. The sensitivity/specificity of , and liquid-based cytology (LBC) for hrHPV-infected women with transformation zone 3 CIN3+ was 83. Read More

IJID Reg 2021 Dec 21;1:130-134. Epub 2021 Oct 21.

Department of Microbiology, University of Dhaka, Dhaka, 1000, Bangladesh.

Objective: Human papillomavirus (HPV) comprises around 120 genotypically related viruses, classified into low- and high-risk HPVs, which are capable of replicating inside the keratinocytes of skin or mucous membranes. Studies suggest that infections with HPV-16 or HPV-18 have a higher rate of developing cancer. The aim of our study was to detect HPV early, and to estimate the genotype-specific prevalence of HPV in apparently healthy and asymptomatic females in Bangladesh. Read More

Appl Bionics Biomech 2022 17;2022:5450575. Epub 2022 Jun 17.

Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

Objective: To construct a case management model of synchronous radiotherapy and concurrent chemotherapy and radiochemotherapy (CRR) for cervical cancer led by nurses and carry out preliminary implementation and evaluation, so as to explore a new model of nursing practice.

Methods: Totally 80 cervical cancer patients were included in this study, 43 patients were in the experimental group, and 37 patients were in the control group. The clinical data, side effects, psychological reactions, and nutritional indexes were collected before and after the intervention. Read More

Front Oncol 2022 9;12:914765. Epub 2022 Jun 9.

Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

[This corrects the article DOI: 10.3389/fonc.2021. Read More

Front Oncol 2022 8;12:883591. Epub 2022 Jun 8.

Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background: Numerous studies reported connection between papillary thyroid carcinoma (PTC) and thyroid autoantibody in adults, but few of them have investigated whether there is a similar link in children and adolescents. The purpose of this research was to explore the relationship between clinicopathological features, prognosis and preoperative thyroid peroxidase antibody (TPOAb) as well as thyroglobulin antibody (TgAb) status in children and adolescents with PTC.

Methods: This study retrospectively reviewed 179 patients of PTC who underwent a thyroidectomy from January 2000 to June 2021 at Tianjin Medical University Cancer Hospital. Read More

Front Oncol 2022 8;12:851244. Epub 2022 Jun 8.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objectives: The current study evaluates the performance of dual-energy computed tomography (DECT) derived extracellular volume (ECV) fraction based on dual-layer spectral detector CT for diagnosing cervical lymph nodes (LNs) metastasis from papillary thyroid cancer (PTC) and compares it with the value of ECV derived from conventional single-energy CT (SECT).

Methods: One hundred and fifty-seven cervical LNs (81 non-metastatic and 76 metastatic) were recruited. Among them, 59 cervical LNs (27 non-metastatic and 32 metastatic) were affected by cervical root artifact on the contrast-enhanced CT images in the arterial phase. Read More

Front Oncol 2022 8;12:840431. Epub 2022 Jun 8.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

The mammary gland is closely related to the female reproductive system in many aspects, affecting the whole gynecological system. Breast cancer (BC) is the most common malignancy in women and associated with considerable negative effects. Due to various factors including co-pathogenic genetic mutations, environment factors, lifestyle, behavioral factors, treatment regimens and in-creased survival of patients with BC, there is an increased probability of developing additional primary gynecologic cancers such as ovarian cancer (OC), endometrial cancer (EC), and cervical cancer (CC). Read More

Front Oncol 2022 8;12:797453. Epub 2022 Jun 8.

Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.

Cervical cancer is the fourth most common cancer in women worldwide. Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the most common histological types, with AC patients having worse prognosis. Over the last two decades, incidence rates of AC have increased, highlighting the importance of further understanding AC tumorigenesis, and the need to investigate new treatment options. Read More

Gynecol Oncol Rep 2022 Aug 17;42:101027. Epub 2022 Jun 17.

NN Alexandrov National Cancer Centre, Minsk, Belarus.

The combination of lower genital tract carcinomas with genitourinary malformations is a rare occurrence. The purpose of this report is to describe the case of high-grade cervical dysplasia of the left cervix of a woman with a uterine didelphys and additional urinary tract malformations. Read More

Technol Health Care 2022 Jun 9. Epub 2022 Jun 9.

Key Laboratory of Laser Life Science, Ministry of Education, College of Biophotonics, South China Normal University, Guangzhou, Guangdong, China.

Background: Cervical histopathology image classification is a crucial indicator in cervical biopsy results.

Objective: The objective of this study is to identify histopathology images of cervical cancer at an early stage by extracting texture and morphological features for the Support Vector Machine (SVM) classifier.

Methods: We extract three different texture features and one morphological feature of cervical histopathology images: first-order histogram, K-means clustering, Gray Level Co-occurrence Matrix (GLCM) and nucleus feature. Read More

J Clin Lab Anal 2022 Jun 26:e24560. Epub 2022 Jun 26.

Gynecology Department, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Transient receptor potential channel 1 (TRPC1) promotes tumor growth and metastasis in endometrial carcinoma (EC) cell lines, whereas its clinical role in EC management remains unclear. Therefore, this study aimed to investigate the association of TRPC1 protein expression with the clinical features and survival of EC patients, then was further validated by TRPC1 mRNA measurement and data from The Human Protein Atlas.

Methods: TRPC1 protein expression in tumor tissues and normal endometria of 176 resectable EC patients was determined using immunohistochemistry. Read More

Eur J Obstet Gynecol Reprod Biol 2022 Jun 8;275:64-69. Epub 2022 Jun 8.

Gynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy.

Surgery is the mainstay of treatment in the management of early-stage cervical cancer. Until the publication of the Laparoscopic Approach to Cervical Cancer (LACC) trial, minimally invasive radical hysterectomy was the recommended approach to treat patients with early-stage disease. The results of the LACC trial questioned the adoption of minimally invasive surgery in cervical cancer. Read More

BMC Health Serv Res 2022 Jun 25;22(1):824. Epub 2022 Jun 25.

Institute of Child Health, College of Medicine, University of Ibadan, PMB 5116, Oyo, 200001, Ibadan, Nigeria.

Background: The human Papillomavirus (HPV) vaccine has demonstrated efficacy in the prevention of cervical cancer when given in early adolescence. The recommendation of the vaccine by health care workers (HCW) is crucial to the uptake of the vaccine by adolescents and the process of this recommendation is important as it determines subsequent uptake of the vaccine. Understanding of the facilitators and barriers of recommendation of this vaccine can help in the development of strategies to improve its recommendation rates and uptake. Read More

Virol J 2022 Jun 25;19(1):106. Epub 2022 Jun 25.

Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O. Box: 1316943551, Tehran, Iran.

Background: MDA-7/IL-24 cytokine has shown potent antitumor properties in various types of cancer without exerting any significant toxicity on healthy cells. It has also been proved to encompass pro-immune Th1 cytokine-like behavior. Several E7 DNA vaccines have developed against human papillomavirus (HPV)-related cervical cancer. Read More

J Integr Med 2022 Jun 15. Epub 2022 Jun 15.

Department of Botany, University of Calcutta, Kolkata, West Bengal 700019, India. Electronic address:

Objective: "Multi-targeting" drugs can prove fruitful to combat drug-resistance of multifactorial disease-cervical cancer. This study envisioned to reveal if Thuja homeopathic mother tincture (MT) and its bioactive component could combat human papillomavirus (HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated warts.

Methods: Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species (ROS) generation by 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) staining and loss in mitochondrial membrane potential (MtMP) by rhodamine 123 (Rh123) staining. Read More

Genes Genomics 2022 Jun 25. Epub 2022 Jun 25.

Department of Gynecology, Hebei General Hospital, Shijiazhuang, China.

Background: Radiotherapy resistance affects the therapeutic effect of cervical squamous cell carcinoma (CSCC). Smoothened (Smo) is an anticancer target of the Hedgehog (Hh) pathway and its mutation is related to drug resistance.

Objective: To explore the roles of miR-326 and Smoothened (SMO) on radiation resistance in patients with cervical carcinoma. Read More

Acta Obstet Gynecol Scand 2022 Jun 25. Epub 2022 Jun 25.

Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.

Advanced and recurrent gynecological cancers are associated with a poor prognosis and there is still a lack of effective treatments. Immune checkpoint blockade (ICB) therapy is an important element of cancer-targeted therapy and immunotherapy. The programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) pathways are the two main targets of ICB. Read More

Int J Cancer 2022 Jun 25. Epub 2022 Jun 25.

Research Institute and Hospital, National Cancer Center, Goyang, South Korea.

We conducted a prospective phase II study on whether extended-field irradiation (EFI) confers survival benefits depending on hypoxic markers in locally advanced uterine cervical cancer (LAUCC). RNA-seq was performed to identify immune and hypoxic gene signatures. A total of 288 patients were randomized to either EFI or pelvic radiotherapy (PRT). Read More

J Pak Med Assoc 2022 Jun;72(6):1025-1030

Department of Gynaecology and Obstetrics, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Objectives: To assess knowledge, attitude and practice of medical and paramedical staff about cervical cancer as well as its screening and prevention.

Methods: The descriptive cross-sectional study was conducted at the Jinnah Post-graduate Medical Centre, Karachi, from March 1 to August 30, 2019, and comprised women medical and paramedical staff randomly selected from different specialties. Data was collected using a structured questionnaire. Read More

BMC Chem 2022 Jun 24;16(1):47. Epub 2022 Jun 24.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, 00970, Palestine.

Background: Cancer is one of the most dangerous and widespread diseases in the world today and it has risen to the position of the leading cause of death around the globe in the last few decades. Due to the inherent resistance of many types of cancer to conventional radiotherapy and chemotherapy, it is vital to develop innovative anticancer medications. Recently, a strategy based on nanotechnology has been used to improve the effectiveness of both old and new cancer drugs. Read More

Brachytherapy 2022 Jun 21. Epub 2022 Jun 21.

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Purpose: Pelvic sidewall recurrence after hysterectomy for uterine malignances has a poor prognosis, and the salvage therapy for this type of recurrence is still challenging. The purpose of this study was to investigate the efficacy of freehand high-dose-rate interstitial brachytherapy (HDR-ISBT) through the perineum using transrectal ultrasonography for this disease.

Methods And Materials: We retrospectively evaluated 42 patients with pelvic sidewall recurrence after hysterectomy for uterine cervical and endometrial cancers. Read More

J Epidemiol Community Health 2022 Jun 24. Epub 2022 Jun 24.

The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.

Background: While many high-income countries including Australia have successfully implemented a range of tobacco control policies, smoking remains the leading preventable cause of cancer death in Australia. We have projected Australian mortality rates for cancer types, which have been shown to have an established relationship with cigarette smoking and estimated numbers of cancer deaths attributable to smoking to 2044.

Methods: Cancer types were grouped according to the proportion of cases currently caused by smoking: 8%-30% and >30%. Read More

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Obstetrics and Gynecology, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, Japan.

A woman in her 30s with cervical cancer underwent postoperative chemotherapy and showed allergic reactions to multiple taxanes. As the patient had infusion reactions to both paclitaxel and docetaxel, a prick test with Cremophor was conducted. In the absence of an allergic reaction to etoposide, we determined that the patient was allergic to pure taxane compounds. Read More