99,331 results match your criteria Cervical Cancer


Somatotopic organization of the human spinothalamic tract: in vivo computed tomography-guided mapping in awake patients undergoing cordotomy.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

3Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

OBJECTIVEThe location of the human spinothalamic tract (STT) in the anterolateral spinal cord has been known for more than a century. The exact nature of the neuronal fiber lamination within the STT, however, remains controversial. After correlating in vivo macrostimulation-induced pain/temperature sensation during percutaneous cervical cordotomy with simultaneous CT imaging of the electrode tip location, the authors present a modern description of the somatotopy of the human cervical STT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.11.SPINE18172DOI Listing
February 2019

Risk factors for pelvic and distant recurrence in locally advanced cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:6-12. Epub 2019 Feb 6.

Medical Oncology Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. Electronic address:

Objective: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.01.028DOI Listing
February 2019

Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2019.01.033DOI Listing
February 2019

Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2019.02.022DOI Listing
February 2019

Gynecologic Cancer in HIV-Positive Women: a Systematic Review and Meta-analysis.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD; The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:

Objective: While there is a significant body of literature on cervical cancer in HIV-positive women, little is known about other gynecologic cancers in this population. The objective of this systematic review and meta-analysis is to describe the incidence, presentation, treatment, and outcomes for HIV-positive women with non-AIDS-defining gynecologic cancers.

Data Source: We searched Medline, Embase, ClinicalTrials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2019.02.022DOI Listing
February 2019

A high-risk papillomavirus 18 E7 affibody-enabled in vivo imaging and targeted therapy of cervical cancer.

Appl Microbiol Biotechnol 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Wenzhou Medical University, Wenzhou, 325035, China.

High-risk papillomavirus (HPV) is one of the major reasons for cervical cancer, causing most lethal gynecologic malignancies worldwide. For cervical cancer progression, oncogene E7 plays vital roles and is used as one of the major targets for cervical tumor diagnosis and treatment. In the clinic, successful treatment of cervical cancer relies on diagnosing the disease at an early stage, where a late-stage diagnosis usually led to treatment failure. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00253-019-09655-9
Publisher Site
http://dx.doi.org/10.1007/s00253-019-09655-9DOI Listing
February 2019
1 Read

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Medical Oncology, University of Colorado Anschutz Medical Campus.

Purpose: IDO1 induces immune suppression in T cells through L-tryptophan (Trp) depletion and kyneurinine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T-cells and hyperactivating Tregs. Navoximod is an investigational small molecule inhibitor of IDO1. This Phase I study evaluated safety, tolerability, PK and PD of navoximod in combination with atezolizumab, a PD-L1 inhibitor, in patients with advanced cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-2740DOI Listing
February 2019

A H2AX⁻CARP-1 Interaction Regulates Apoptosis Signaling Following DNA Damage.

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

John D. Dingell Veterans Administration Medical Center, Detroit, MI 48201, USA.

Cell Cycle and Apoptosis Regulatory Protein (CARP-1/CCAR1) is a peri-nuclear phosphoprotein that regulates apoptosis via chemotherapeutic Adriamycin (doxorubicin) and a novel class of CARP-1 functional mimetic (CFM) compounds. Although Adriamycin causes DNA damage, data from Comet assays revealed that CFM-4.16 also induced DNA damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020221DOI Listing
February 2019

Influence of 18F-FDG-PET/CT on staging of cervical cancer.

Nuklearmedizin 2019 Feb 15;58(1):17-22. Epub 2019 Feb 15.

Chair and Department of Electroradiology, Poznan University of Medical Science.

Aim: Cervical cancer is one of the most common cancers of the female reproductive system. The aim of the study was to assess the usefulness of the F-FDG-PET/CT study in staging of cervical cancer, with focus on the primary tumor parameters.

Material & Methods: 105 patients (mean age 56 ± 11y) with newly diagnosed cervical cancer underwent PET/CT examination which was performed 60 min after IV injection of F-FDG with a mean activity of 364 ± 75MBq. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0809-4577DOI Listing
February 2019

Affective and Cognitive Attitudes on Cervical Health Behaviors Among Asian American Women.

Fam Community Health 2019 Apr/Jun;42(2):123-132

College of Nursing, The University of New Mexico, Albuquerque (Dr J. Lee); Department of Psychology, University of Oklahoma, Norman (Dr Carvallo); UCLA School of Nursing (Dr E. Lee); Virginia Commonwealth University School of Nursing, Richmond (Dr Chung); and Arizona State University College of Nursing and Health Innovation, Phoenix (Dr Shin).

Cervical cancer is a major cause of death for Vietnamese and Korean American women, yet their screening rates remain low. This study explored factors influencing cervical health behaviors of these populations, using a 2-dimensional model (ie, affect and cognition) of attitude structure approach. Semistructured interviews were conducted with 33 participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FCH.0000000000000216DOI Listing
February 2019

HPV vaccination in Japan: what is happening in Japan?

Expert Rev Vaccines 2019 Feb 15. Epub 2019 Feb 15.

a Deptartent of Gynecology, Tama-Hokubu Medical Center , Tokyo Metropolitan Health and Medical Treatment Corporation , Higashimurayama, Tokyo , Japan.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
Publisher Site
http://dx.doi.org/10.1080/14760584.2019.1584040DOI Listing
February 2019
2 Reads

Correction to: Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study.

BMC Cancer 2019 Feb 15;19(1):152. Epub 2019 Feb 15.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Following publication of the original article [1], the authors notified us of an error in the reported percentages in Table 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-019-5357-2DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019

Unusual Sites of Metastatic and Benign I 131 Uptake in Patients with Differentiated Thyroid Carcinoma.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):740-750

Department of Nuclear Medicine and Molecular Imaging, Amrita Institute of Medical Sciences, Amrita Vishwavidyapeetham, Cochin, Kerala, India.

Introduction: Differentiated thyroid carcinoma (DTC) is the most common pathological type of thyroid carcinoma, which includes papillary and follicular subtypes. DTC is usually indolent, characterized by good prognosis, and long-term survival. Total thyroidectomy is the mainstay of treatment in DTC which is followed by diagnostic whole body 131I (WBI) scan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijem.IJEM_70_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330860PMC
February 2019
1 Read

International radical trachelectomy assessment: IRTA study.

Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Oncological surgery, Clinica Astorga, Envigado, Colombia.

Background: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy.

Primary Objective: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-000273DOI Listing
February 2019

OLFM4 inhibits epithelial-mesenchymal transition and metastatic potential of cervical cancer cells.

Oncol Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Gynecology, Jinan Women and Children's Health Hospital, Jinan, Shandong, 250001, P.R. China.

OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3727/096504018X15399955297355DOI Listing
February 2019

Vaccination against HPV and view of new possibilities.

Ceska Gynekol 2018 ;83(3):218-225

Objective: Overview of available information on current vaccination options against HPV and possibilities for further development.

Design: Review article.

Settings: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava; Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

View Article

Download full-text PDF

Source
January 2018
1 Read

PEGylated peptide to TIP1 is a novel targeting agent that binds specifically to various cancers in vivo.

J Control Release 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

Targeted molecular imaging allows specific visualization and monitoring of tumors. Cancer-specific peptides have been developed for imaging and therapy. Peptides that specifically target cancer have several advantages including, ease of synthesis, low antigenicity, and enhanced diffusion into tissues. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01683659193008
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2019.02.008DOI Listing
February 2019
3 Reads

Screening for Cervical Cancer.

Am Fam Physician 2019 Feb;99(4):253-254

National Cancer Institute, USA.

View Article

Download full-text PDF

Source
February 2019

Screening for Cervical Cancer: Recommendation Statement.

Authors:

Am Fam Physician 2019 Feb;99(4):Online

View Article

Download full-text PDF

Source
February 2019

Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement.

Head Neck 2019 Feb 14. Epub 2019 Feb 14.

Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Background: Parotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien.

Methods: In total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed.

Results: Lymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25670DOI Listing
February 2019

Electrical stimulation on adverse events caused by chemotherapy in patients with cervical cancer: A protocol for a systematic review of randomized controlled trial.

Medicine (Baltimore) 2019 Feb;98(7):e14609

Department of Gynecology.

Background: This protocol of systematic review aims to investigate the effectiveness of electrical stimulation (ES) on adverse events (AEs) caused by chemotherapy in patients with cervical cancer (CC).

Methods: This systematic review of randomized controlled trials will be identified through searchers of PUBMED, PsycINFO, Scopus, Opengrey, Cochrane Central Register of Controlled Trials, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. All the sources will be searched from the inception to the date of study search ran. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014609DOI Listing
February 2019

The Role of Significantly Deregulated MicroRNAs in Recurrent Cervical Cancer Based on Bioinformatic Analysis of the Cancer Genome Atlas Data.

J Comput Biol 2019 Feb 14. Epub 2019 Feb 14.

Oncology Department, Xiangya Hospital, Central South University, Changsha, P.R. China.

To screen for differentially expressed microRNAs (miRNAs) between recurrent and primary cervical cancer patient samples, and investigate the prognostic value of the identified miRNAs, based on The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs between recurrent and primary cervical cancer, identified from TCGA database, were selected by edgeR package in the R software. Overlapping target genes predicted by TargetScan, miRTarBase, and miRDB online analysis tools were chosen for Gene Ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/cmb.2018.0241DOI Listing
February 2019
1 Read

Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients.

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06017-xDOI Listing
February 2019
1 Read

Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019

The Octamer-Binding Transcription Factor 4 (OCT4) Pseudogene, POU Domain Class 5 Transcription Factor 1B (POU5F1B), is Upregulated in Cervical Cancer and Down-Regulation Inhibits Cell Proliferation and Migration and Induces Apoptosis in Cervical Cancer Cell Lines.

Med Sci Monit 2019 Feb 14;25:1204-1213. Epub 2019 Feb 14.

Taixing Peoples' Hospital Affiliated to Bengbu Medical College, Taixing, Jiangsu, China (mainland).

BACKGROUND The POU domain class 5 transcription factor 1B (POU5F1B), is a pseudogene that is homologous to octamer-binding transcription factor 4 (OCT4), and is located adjacent to the MYC gene on human chromosome 8q24. POU5F1B has been reported to be transcribed in several types of cancer, but its role in cervical cancer remains unclear. This study aimed to investigate the expression and function of POU5F1B in tissue samples of human cervical cancer and in cervical cancer cell lines in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912109DOI Listing
February 2019
2 Reads

Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

Turk J Med Sci 2019 Feb 11;49(1):217-221. Epub 2019 Feb 11.

Backround/aim: Papillary thyroid carcinomas (PTC) frequently metastasize to regional lymph nodes. Our purpose was to investigate the predictive role of tumor location for lymph node metastasis pattern in PTCs.

Materials And Methods: Medical records of 110 PTC patients were reviewed retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3906/sag-1807-79DOI Listing
February 2019

Cytological features of uterine tumors resembling ovarian sex-cord tumors in liquid-based cervical cytology: a potential pitfall. Report of a unique and rare case.

Diagn Cytopathol 2019 Feb 13. Epub 2019 Feb 13.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype. Most tumors are associated with a benign clinical course. We report the first cytological description of uterine UTROSCTs in liquid-based cervical cytology (LBC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dc.24153DOI Listing
February 2019

MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.

Front Oncol 2019 29;9:29. Epub 2019 Jan 29.

Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.

Cervical cancer is the fourth most common cancer type in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this immunosuppressive microenvironment. Expression of a specific carbohydrate ligand for the immune-regulatory C-type lectin MGL was correlated to poor disease-specific survival and distant recurrences in squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC), the most common histological subtypes of cervical cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361794PMC
January 2019

Establishment, molecular and biological characterization of HCB-514: a novel human cervical cancer cell line.

Sci Rep 2019 Feb 13;9(1):1913. Epub 2019 Feb 13.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.

Cervical cancer is the fourth most common cancer in women. Although cure rates are high for early stage disease, clinical outcomes for advanced, metastatic, or recurrent disease remain poor. To change this panorama, a deeper understanding of cervical cancer biology and novel study models are needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-38315-7DOI Listing
February 2019

The Urodynamics and Survival Outcomes of Different Methods of Dissecting the Inferior Hypogastric Plexus in Laparoscopic Nerve-Sparing Radical Hysterectomy of Type C: A Randomized Controlled Study.

Ann Surg Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.

Background: Little data exist about the impact of dissection methods on bladder function during nerve-sparing radical hysterectomy (NSRH). This randomized controlled trial compared the urodynamic and survival outcomes of different methods dissecting the inferior hypogastric plexus (IHP) during laparoscopic NSRH.

Methods: Eligible patients presenting with stage IB cervical cancer from 9 May 2013 to 27 October 2015 were randomized at a ratio of 1:1 and subjected to waterjet (study group) or traditional blunt (control group) dissection of the IHP for laparoscopic type C radical hysterectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07228-8DOI Listing
February 2019

Primary Malignant Thyroid Teratoma: An Institutional Experience.

Thyroid 2019 Feb;29(2):229-236

1 Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Primary malignant thyroid teratomas are very rare tumors (fewer than 35 previously reported cases in the literature) typically affecting young adult women. While prognosis is poor, there have been some reports of successful treatment regimens. Four cases treated successfully are reported, and a review of the existing literature is provided. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/thy.2018.0206DOI Listing
February 2019

Role of MRI in staging and follow-up of endometrial and cervical cancer: pitfalls and mimickers.

Insights Imaging 2019 Feb 13;10(1):19. Epub 2019 Feb 13.

Department of Clinical Radiology, Ninewells Hospital and Medical School, Dundee, UK.

MRI plays important roles in endometrial and cervical cancer assessment, from detection to recurrent disease evaluation. Endometrial cancer (EC) is the most common malignant tumor of the female genital tract in Western countries. EC patients are divided into risk categories based on histopathological tumor type, grade, and myometrial invasion depth. Read More

View Article

Download full-text PDF

Source
https://insightsimaging.springeropen.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s13244-019-0696-8DOI Listing
February 2019
1 Read

Intra- and inter-laboratory agreement of the FAM19A4/mir124-2 methylation test: Results from an international study.

J Clin Lab Anal 2019 Feb 13:e22854. Epub 2019 Feb 13.

Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Background: HPV-based cervical screening detects women at an increased risk of cervical cancer and precancer. To differentiate among HPV-positive women those with (pre)cancer, triage testing is necessary. The detection of cancer-associated host-cell DNA methylation (FAM19A4 and hsa-mir124-2) in cervical samples has shown valuable as triage test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcla.22854DOI Listing
February 2019

MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, Heze Municipal Hospital, Heze, Shandong, China.

Patients with cervical cancer have abnormal cell proliferation and invasion after many years of latency. However, the precise mechanisms remain unclear. Mitogen- and stress-activated kinase 2 (MSK2) is a serine/threonine kinase which displays a phenotype that promotes tumor growth and metastasis in many different types of tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28421DOI Listing
February 2019

The impact of low volume lymph node metastases and stage migration after pathologic ultrastaging of non-sentinel lymph nodes in early-stage cervical cancer: a study of 54 patients with 4.2 years of follow up.

Ginekol Pol 2019 ;90(1):20-30

Department of Gynecology, Gynecologic Oncology and Gynecologic Endocrinology, Medical University of Gdansk, Poland.

Objectives: To assess the significance of pathologic ultrastaging (PU) of sentinel (SLN) and non-sentinel (nSLN) lymph nodes (LNs) and the influence on cancer staging in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IB1 cervical cancer.

Material And Methods: A retrospective study was conducted with 54 patients divided into two equal-sized groups. In test group (n1), at least one SLN/patient was detected with blue dye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5603/GP.2019.0004DOI Listing
January 2019

Perceptions of Cancer Causes, Prevention, and Treatment Among Navajo Cancer Survivors.

J Cancer Educ 2019 Feb 12. Epub 2019 Feb 12.

College of Health and Human Services, Northern Arizona University, Flagstaff, AZ, USA.

Native Americans experience cancer-related health disparities. Yet, little is known about the current cancer experience in one of the largest Native American tribe, Navajo. A qualitative study of among Navajo cancer survivors, in which focus groups and individual interviews included questions related to perceptions of cancer causes, prevention, and treatment, allowed us to evaluate several aspects of the cancer experience from the Navajo perspective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13187-019-01487-5DOI Listing
February 2019

Molecular Diagnosis of Human Papilloma Virus by PCR.

Mymensingh Med J 2019 Jan;28(1):175-181

Dr Faijun Nahar, Assistant Professor, Department of Microbiology, President Abdul Hamid Medical College, Kishoreganj, Bangladesh.

Cervical cancer is a major world health problem and the fourth most leading cause of death in women around the world. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers worldwide. Read More

View Article

Download full-text PDF

Source
January 2019

Knowledge, Attitude and Practice of Bangladeshi Women towards Breast Cancer: A Cross Sectional Study.

Mymensingh Med J 2019 Jan;28(1):96-104

Professor Shirin Akter Begum, Professor, Department of Gynaecological Oncology, Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka, Bangladesh; E-mail:

In Bangladesh incidence rate of breast cancer was about 22.5 per 100000 females. Breast cancer has been reported as the highest prevalence rate (19. Read More

View Article

Download full-text PDF

Source
January 2019

Distribution of HPV-16 and HPV-18 from the Patients Attending At Mymensingh Medical College Hospital by Newly Developed Oncoprotein Detection Assay.

Mymensingh Med J 2019 Jan;28(1):31-36

Dr Sahida Abedin, Lecturer, Department of Virology, MMC, Mymensingh, Bangladesh; E-mail:

Cervical cancer is one of cause of death in women in many developing countries. Persistent infection with Human Papilloma Virus (HPV), primarily high risk types 16 and 18, is recognized as a causal and essential factor for the development of cervical cancer. The objective of this cross sectional observational study is to detect the distribution of HPV-16 and HPV-18 among Onco E6 positive cases. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling.

MBio 2019 Feb 12;10(1). Epub 2019 Feb 12.

Molecular Therapy of Virus-Associated Cancers, German Cancer Research Center (DKFZ), Heidelberg, Germany

Hypoxia is linked to therapeutic resistance and poor clinical prognosis for many tumor entities, including human papillomavirus (HPV)-positive cancers. Notably, HPV-positive cancer cells can induce a dormant state under hypoxia, characterized by a reversible growth arrest and strong repression of viral E6/E7 oncogene expression, which could contribute to therapy resistance, immune evasion and tumor recurrence. The present work aimed to gain mechanistic insights into the pathway(s) underlying HPV oncogene repression under hypoxia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.02323-18DOI Listing
February 2019

Efficacy of PD-1 blockade in cervical cancer is related to a CD8FoxP3CD25 T-cell subset with operational effector functions despite high immune checkpoint levels.

J Immunother Cancer 2019 Feb 12;7(1):43. Epub 2019 Feb 12.

Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Background: Cervical cancer (CxCa) is mainly a locally invading disease that metastasizes to loco-regional lymph node basins before involving distant organs in more advanced stages. Local immune potentiation of tumor-draining lymph nodes (TDLN) may thus protect against tumor progression.

Methods: To identify therapeutic targets for local immune modulation, multi-parameter flow cytometric T-cell profiling of primary cervical tumors (PT) and TDLN (n = 37) was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0526-zDOI Listing
February 2019

A pap-smear analysis tool (PAT) for detection of cervical cancer from pap-smear images.

Biomed Eng Online 2019 Feb 12;18(1):16. Epub 2019 Feb 12.

Department of Biomedical Sciences and Engineering, Mbarara University of Science and Technology, Mbarara, 1410, Uganda.

Background: Cervical cancer is preventable if effective screening measures are in place. Pap-smear is the commonest technique used for early screening and diagnosis of cervical cancer. However, the manual analysis of the pap-smears is error prone due to human mistake, moreover, the process is tedious and time-consuming. Read More

View Article

Download full-text PDF

Source
https://biomedical-engineering-online.biomedcentral.com/arti
Publisher Site
http://dx.doi.org/10.1186/s12938-019-0634-5DOI Listing
February 2019
1 Read
1.427 Impact Factor

Hematologic markers of distant metastases and poor prognosis in gynecological cancers.

BMC Cancer 2019 Feb 12;19(1):141. Epub 2019 Feb 12.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, 11941, Jordan.

Background: Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the carcinogenesis process including metastasis. The high neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) were found to be associated with poor survival rates in the majority of solid tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-019-5326-9DOI Listing
February 2019

Significance of serum antibodies against HPV E7, Hsp27, Hsp20 and Hp91 in Iranian HPV-exposed women.

BMC Infect Dis 2019 Feb 12;19(1):142. Epub 2019 Feb 12.

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.

Background: Among different types of human papillomavirus (HPV), types 16 and 18 were known to be high-risk agents causing mainly cervical cancer. Up to now, the potential of HPV E7 protein has been proved as a diagnostic marker of cervical cancer. Moreover, the levels of anti-heat shock protein (Hsp) and anti-high mobility group box-1 (HMGB1) antibodies in cancer patients have been useful in tumor diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-3780-2DOI Listing
February 2019

[The impact of the HPV test in screening programs in Latin America: The case of Argentina].

Authors:
Silvina Arrossi

Salud Publica Mex 2019 Ene-Feb;61(1):86-94

Consejo Nacional de Investigaciones Científicas yTécnicas/Centro de Estudios de Estado y Sociedad. Buenos Aires,Argentina.

Objective: To assess the impact of HPV testing on longstanding problems faced by screening programs in Latin America, using the case of the Jujuy Demonstration Project (JDP) in Argentina.

Materials And Methods: . The study measured the level of impact produced by the introduction of HPV-testing on problems faced by cytology programs by analyzing modifications on specific problems produced during the JDP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21149/9257DOI Listing
November 2017

Preventive healthcare-seeking behavior among poor older adults in Mexico: the impact of Seguro Popular, 2000-2012.

Salud Publica Mex 2019 Ene-Feb;61(1):46-53

Department of Health Services, Policy and Practice, Brown University. Providence, Rhode Island, USA.

Objective: Determine the effect of Seguro Popular (SP) on preventive care utilization among low-income SP beneficiaries and uninsured elders in Mexico.

Materials And Methods: Fixed-effects instrumental-variable (FE-IV) pseudo-panel estimation from three rounds of the Mexican National Health and Nutrition Survey (2000, 2006 and 2012).

Results: Our findings suggest that SP has no significant effect on the use of preventive services, including screening for diabetes, hypertension, breast cancer and cervical cancer, by adults aged 50 to 75 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21149/9185DOI Listing
October 2017
1 Read