100,296 results match your criteria Cervical Cancer


Bethesda 2014 Implementation and Human Papillomavirus Primary Screening: Practices of Laboratories Participating in the College of American Pathologists PAP Education Program.

Arch Pathol Lab Med 2019 Apr 25. Epub 2019 Apr 25.

From the Department of Clinical Sciences, University of Central Florida College of Medicine, Orlando (Dr Davey); the Department of Biostatistics (Ms Souers) and the Surveys Department (Ms Goodrich), College of American Pathologists, Northfield, Illinois; the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Dr Mody); the Department of Pathology, The George Washington University, Washington, DC (Dr Tabbara); and the Department of Pathology, Cleveland Clinic, Cleveland, Ohio (Dr Booth).

Context.—: Cervical cancer screening laboratory practices may evolve with new terminology and technologies.

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http://dx.doi.org/10.5858/arpa.2018-0603-CPDOI Listing
April 2019
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Visual techniques for cervical cancer screening in Colombia.

Biomedica 2019 Mar 31;39(1):65-74. Epub 2019 Mar 31.

Subdirección de Investigaciones y Salud Pública, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.

Introduction: Direct visual inspection for cervical cancer screening remains controversial, whereas colposcopy-biopsy is considered the gold standard for diagnosis of preneoplastic cervical lesions.

Objectives: To determine the rates of cervical intraepithelial neoplasia grade 2 or more and of false positives for colposcopy and direct visual inspection.

Materials And Methods: Women aged 25-59 underwent direct visual inspection with acetic acid (VIA), Lugol's iodine (VIA-VILI), and colposcopy. Read More

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http://dx.doi.org/10.7705/biomedica.v39i1.4007DOI Listing

Safety and efficacy of thermal ablation for subpleural lung cancers.

Thorac Cancer 2019 Apr 25. Epub 2019 Apr 25.

Minimally Invasive Interventional Center, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Background: The study was conducted to assess the safety and efficacy of thermal ablation for the treatment of subpleural lung cancer.

Methods: Eighty-nine patients with 101 subpleural lung cancers were identified between January 2012 and July 2018 in our database and included in this study. Tumors were classified as adhering to cervical, costal, diaphragmatic, and mediastinal pleurae. Read More

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http://dx.doi.org/10.1111/1759-7714.13068DOI Listing

Using a Culturally Tailored Narrative to Increase Cervical Cancer Detection Among Spanish-Speaking Mexican-American Women.

J Cancer Educ 2019 Apr 24. Epub 2019 Apr 24.

Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

The objective of this study was to determine the feasibility and effectiveness of translating films, and whether the use of narrative is an effective vehicle for producing changes in knowledge, attitudes, and behaviors regarding cervical cancer compared with a nonnarrative film. A randomized controlled telephone trial surveyed the effectiveness of two films our team produced among a sample of 300 monolingual Spanish-speaking women, ages 25 to 45, who were of Mexican origin. Participants were recruited using random digit dialing (RDD) procedures from 2013 to 2014 in Los Angeles County and were randomly selected to view either a narrative or nonnarrative film. Read More

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http://dx.doi.org/10.1007/s13187-019-01521-6DOI Listing

Palliative pelvic exenteration using iliofemoral bypass with synthetic grafts for advanced cervical carcinoma.

Turk J Obstet Gynecol 2019 Mar 27;16(1):80-83. Epub 2019 Mar 27.

Suleyman Demirel University Faculty of Medicine, Department of Gynecologic Oncology, Isparta, Turkey.

Objective: Recurrent cervical cancer can cause severe morbidity. Despite the severe morbidity after surgery, pelvic exenteration is still used today for mainly curative intent. This intention is neither based on randomized controlled trials (RCTs) nor high quality non-RCTs with adequate patient numbers comparing medical management with surgery. Read More

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http://dx.doi.org/10.4274/tjod.galenos.2018.66743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463427PMC

Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway.

Oxid Med Cell Longev 2019 25;2019:9675450. Epub 2019 Mar 25.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent cancer cell apoptosis-inducing factor that can induce apoptosis in a variety of cancer cells. However, resistance to TRAIL in cancer cells is a huge obstacle in creating effective TRAIL-targeted clinical therapies. Thus, agents that can either enhance the effect of TRAIL or overcome its resistance are needed. Read More

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http://dx.doi.org/10.1155/2019/9675450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452544PMC

Clinical impact and cost-effectiveness of primary cytology versus human papillomavirus testing for cervical cancer screening in England.

Int J Gynecol Cancer 2019 Apr 24. Epub 2019 Apr 24.

Modelling and Economics Unit, Public Health England, London, UK

Objectives: In England, human papillomavirus (HPV) testing is to replace cytological screening by 2019-2020. We conducted a model-based economic evaluation to project the long-term clinical impact and cost-effectiveness of routine cytology versus HPV testing.

Methods: An individual-based model of HPV acquisition, natural history, and cervical cancer screening was used to compare cytological screening and HPV testing with cytology triage for women aged 25-64 years (with either 3- or 5-year screening intervals for women aged under 50 years). Read More

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http://dx.doi.org/10.1136/ijgc-2018-000161DOI Listing

A systematic review of sexuality and depression of cervical cancer patients.

J Sex Marital Ther 2019 Apr 24:1-35. Epub 2019 Apr 24.

b Pain Relief and Palliative Care Unit, Department of Radiology, Areteion Hospital, School of Medicine , National &KapodistrianUniversity of Athens, School of Medicine , 27 Korinthias St. , 115 26 Athens , Greece .

Objectives: To investigate the correlation between sexuality and depression of CC patients.

Methods: Bibliographical search was carried out in the databases: CINAHL, Pubmed, Cochrane Library, with the following terms: sexuality, sexual function, sexual dysfunction, sexual problems, mood, depression, emotional distress, cervical cancer, in English for the years 2006-2017.

Results: Fourteen studies were included. Read More

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http://dx.doi.org/10.1080/0092623X.2019.1610125DOI Listing

Induces Apoptosis and Suppresses Migration in Cancer Cells: Role of Reactive Oxygen Species.

Biomolecules 2019 Apr 23;9(4). Epub 2019 Apr 23.

Laboratory for Translational Cancer Research, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi-221 005, India.

Although over 100 species of Curcuma are reported, only is extensively studied. , a poorly studied species, is most commonly distributed in the Kerala state of India. For the first time, we examined the efficacy of different fractions (acetone, hexane, and ethyl acetate) of against glioma, cervical, and breast cancer cell lines. Read More

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http://dx.doi.org/10.3390/biom9040159DOI Listing

miR-144 reverses cisplatin resistance in cervical cancer via targeting LHX2.

J Cell Biochem 2019 Apr 24. Epub 2019 Apr 24.

Department of Radiation Oncology, First Hospital of Xi'an Jiaotong Univesity, Xi'an, Shaanxi, China.

Mounting evidence showed that microRNAs involve in development and chemoresistance of various human cancers. We explored the roles and mechanisms of miR-144 in resistance to cisplatin (CDDP) of cervical cancer cells. miR-144 and LIM homeobox 2 (LHX2) expression in CDDP-resistant and the parental cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis, respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28763
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http://dx.doi.org/10.1002/jcb.28763DOI Listing
April 2019
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Comparison of 3D conformal radiation therapy and intensity-modulated radiation therapy in patients with endometrial cancer: efficacy, safety and prognostic analysis.

Acta Oncol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a Department of Radiation Oncology , Tenon University Hospital, Hôpitaux Universitaires Est Parisien, Sorbonne University Medical Faculty , Paris , France.

Introduction: Adjuvant whole-pelvic radiation therapy (WPRT) improves locoregional control for high-intermediate stages I-III endometrial cancer patients. Intensity modulated radiation therapy (IMRT) tends to replace the standard 3D conformal radiation therapy (3DCRT) technique used in trials.

Material And Methods: Consecutive patients with stages I-IIIc endometrial cancer treated between 2008 and 2014 in our department with post-operative 3DCRT or IMRT WPRT were studied retrospectively. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599136DOI Listing

Budget Impact Analysis of Cancer Screening: A Methodological Review.

Appl Health Econ Health Policy 2019 Apr 24. Epub 2019 Apr 24.

Department of Public Health, Health Services Research and Health Technology Assessment, Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT-University for Health Sciences, Medical Informatics and Technology, Eduard-Wallnoefer-Zentrum 1, 6060, Hall in Tyrol, Austria.

Background: Budget impact analyses (BIAs) describe changes in intervention- and disease-related costs of new technologies. Evidence on the quality of BIAs for cancer screening is lacking.

Objectives: We systematically reviewed the literature and methods to assess how closely BIA guidelines are followed when BIAs are performed for cancer-screening programs. Read More

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http://dx.doi.org/10.1007/s40258-019-00475-6DOI Listing

MiR-144-3p: a novel tumor suppressor targeting MAPK6 in cervical cancer.

J Physiol Biochem 2019 Apr 23. Epub 2019 Apr 23.

Heze Municipal Hospital, No. 2888, Caozhou Road, Heze, 274000, Shandong, China.

Cervical cancer is the third most common gynecologic cancer in the world. Exploration of the molecular mechanism underlying cervical cancer pathogenesis will provide new insights into the development of novel therapies. In this study, we were aimed to characterize a novel miRNA in cervical cancer tumorigenesis. Read More

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http://dx.doi.org/10.1007/s13105-019-00681-9DOI Listing

Para-aortic Lymphadenectomy for Gynecologic Cancers: Introducing the "Trans-Retro-Peritoneal (TRP) Single-Port Access".

Ann Surg Oncol 2019 Apr 23. Epub 2019 Apr 23.

Department of Gynaecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Background: In gynecological surgery to date, two distinct types of endoscopic accesses have been used to perform para-aortic lymphadenectomies: transperitoneal and extraperitoneal, each with advantages and disadvantages. We propose to develop a new mini-invasive access to perform an endoscopic extraperitoneal para-aortic lymphadenectomy via a single-port umbilical device that, to our knowledge, has never been described.

Methods: This innovative approach combines both an extraperitoneal and intraperitoneal procedure via the same umbilical incision using one single trocar. Read More

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http://dx.doi.org/10.1245/s10434-019-07379-8DOI Listing

Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy.

Eur Radiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objectives: To investigate the value of blood oxygenation level-dependent (BOLD) MRI as a predictor of clinical outcomes in cervical cancer patients treated with concurrent chemoradiotherapy (CCRT).

Method: Enrolled 92 patients with stage IB2-IVB cervical cancer who received CCRT underwent 3-T BOLD MRI before treatment. The R2* value (rate of spin dephasing, s) was measured in the tumor. Read More

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http://dx.doi.org/10.1007/s00330-019-06198-5DOI Listing

Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection.

Biomed Res Int 2019 21;2019:5829676. Epub 2019 Mar 21.

Center for Cancer Prevention and Detection, Hospital, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si 10408, Republic of Korea.

Tobacco smoking is established as a cofactor of human papillomavirus (HPV) for cervical cancer risk. However, the role of secondhand smoking in cervical carcinogenesis is controversial. We aimed to assess the association between secondhand smoking and high risk- (HR-) HPV persistence, a pivotal event in development of cervical cancer. Read More

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http://dx.doi.org/10.1155/2019/5829676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448343PMC

Syringobulbia in Patients with Chiari Malformation Type I: A Systematic Review.

Biomed Res Int 2019 19;2019:4829102. Epub 2019 Mar 19.

Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, China.

This study aimed to summarize the clinical features, diagnosis, and treatment of Chiari malformation type I- (CM-1-) associated syringobulbia. We performed a literature review of CM-1-associated syringobulbia in PubMed, Ovid MEDLINE, and Web of Science databases. Our concerns were the clinical features, radiologic presentations, treatment therapies, and prognoses of CM-1-associated syringobulbia. Read More

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http://dx.doi.org/10.1155/2019/4829102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444244PMC

Synthesis and X-ray study of dispiro 8-nitroquinolone analogues and their cytotoxic properties against human cervical cancer HeLa cells.

Medchemcomm 2019 Mar 22;10(3):439-449. Epub 2019 Jan 22.

School of Chemical Sciences , Bharathiar University , Coimbatore , Tamil Nadu , India . Email: ; Email:

A series of unique dispiro analogues containing an oxindole pyrrolidine 8-nitroquinolone hybrid has been obtained through a one-pot three-component 1,3-dipolar cycloaddition of azomethine ylides generated from the condensation of isatins and benzylamine with ()-3-arylidene-2,3-dihydro-8-nitro-4-quinolones. The structures of the newly synthesized compounds were characterized by using different spectroscopic techniques and by X-ray diffraction studies of their regio- and stereochemistry. All the synthesized compounds were screened for cytotoxic activity against the human cervical cancer cell line HeLa. Read More

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http://dx.doi.org/10.1039/c8md00482jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457198PMC

The Polyphenolic Composition of Extracts Derived from Different Greek Extra Virgin Olive Oils Is Correlated with Their Antioxidant Potency.

Oxid Med Cell Longev 2019 20;2019:1870965. Epub 2019 Mar 20.

Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.

Olive oil possesses a predominant role in the diet of countries around the Mediterranean basin, whereas it is a known constituent of several sectors of human culture. The polyphenolic composition of olive oil seems to be a key factor in its beneficial biological properties. Based on the above, the aim of this study was to correlate the polyphenolic composition of five extracts derived from a Greek olive oil variety with their antioxidant potency and antimutagenic activities with chemical-based techniques and cell culture-based assays. Read More

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https://www.hindawi.com/journals/omcl/2019/1870965/
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http://dx.doi.org/10.1155/2019/1870965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446106PMC
March 2019
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Barriers and facilitators of follow-up among women with precancerous lesions of the cervix in Cameroon: a qualitative pilot study.

Int J Womens Health 2019 1;11:229-239. Epub 2019 Apr 1.

College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA,

Purpose: This pilot study explores the barriers to adherence to follow-up among women with cervical precancer in urban Cameroon. While follow-up of women with a positive screening of cervical precancer is the most important aspect of cervical cancer secondary prevention, women with cervical precancer do not adhere frequently to recommended follow-up schedule in Cameroon. The aim of the study was to explore and describe the barriers and facilitators to follow-up for cervical precancer among women infected and uninfected with HIV in Cameroon. Read More

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http://dx.doi.org/10.2147/IJWH.S196112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448541PMC

Successful Delivery after Abdominal Radical Trachelectomy, Using Transabdominal Cerclage in Early Pregnancy.

Acta Med Okayama 2019 Apr;73(2):173-176

Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Read More

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http://dx.doi.org/10.18926/AMO/56653DOI Listing
April 2019
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Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx.

Acta Med Okayama 2019 Apr;73(2):109-115

Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61. Read More

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http://dx.doi.org/10.18926/AMO/56646DOI Listing

Predictive value of HPV testing in self-collected and clinician-collected samples compared with cytology in detecting high-grade cervical lesions.

Cancer Epidemiol Biomarkers Prev 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, McGill University.

Background: Self-sampling has become an attractive proposition now that HPV primary testing is being incorporated into cervical cancer screening programs worldwide. We compared predictive values of HPV testing based on self- and physician- collected samples, and cytology, in detecting high-grade cervical intraepithelial neoplasia (CIN).

Methods: The Cervical And Self-Sample In Screening (CASSIS) study enrolled 1217 women aged 16-70 years prior to scheduled colposcopies. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1338DOI Listing

Volumetric assessment of apparent diffusion coefficient predicts outcome following chemoradiation for cervical cancer.

Radiother Oncol 2019 Mar 11;135:58-64. Epub 2019 Mar 11.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States. Electronic address:

Objective: To determine the utility of volumetric diffusion weighted imaging (DWI) compared to other clinical factors for predicting recurrence and survival in cervical cancer patients treated with definitive chemoradiation.

Methods And Materials: We retrospectively studied cervical cancer patients treated with definitive chemoradiation between 2009-2013 at a single institution with a baseline MRI with DWI and 18F-FDG positron emission tomography/computed tomography (FDG-PET) scan. To identify clinical and imaging metrics correlated with survival and recurrence endpoints, variable importance values were calculated from random forest models. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.012DOI Listing
March 2019
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Repeatability and reproducibility of MRI-based radiomic features in cervical cancer.

Radiother Oncol 2019 Mar 19;135:107-114. Epub 2019 Mar 19.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

Purpose: The aims of this study are to evaluate the stability of radiomic features from T2-weighted MRI of cervical cancer in three ways: (1) repeatability via test-retest; (2) reproducibility between diagnostic MRI and simulation MRI; (3) reproducibility in inter-observer setting.

Materials And Methods: This retrospective cohort study included FIGO stage IB-IVA cervical cancer patients treated with chemoradiation between 2005 and 2014. There were three cohorts of women corresponding to each aim of the study: (1) 8 women who underwent test-retest MRI; (2) 20 women who underwent MRI on different scanners (diagnostic and simulation MRI); (3) 34 women whose diagnostic MRIs were contoured by three observers. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.001DOI Listing

Systemic therapy in cervical cancer: 30 years in review.

Crit Rev Oncol Hematol 2019 May 28;137:9-17. Epub 2019 Feb 28.

Oncology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.

Advanced-inoperable cervical cancer is a challenging entity due to increased percentage of locoregional and distant recurrences. Furthermore, recurrent cervical cancer not amenable to radical treatment as well as de novo metastatic disease are considered incurable with dismal prognosis. Well-designed clinical trials conducted during the last 30 years have revealed the active chemotherapeutic agents as well as their optimal combinations. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.02.009DOI Listing

Molecular mechanisms in progression of HPV-associated cervical carcinogenesis.

J Biomed Sci 2019 Apr 23;26(1):28. Epub 2019 Apr 23.

Department of Infectious Diseases Biology, National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, 400012, India.

Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of mortality in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is a necessary cause for the development of cervical cancer. In addition, genetic and epigenetic alterations in host cell genes are crucial for progression of cervical precancerous lesions to invasive cancer. Read More

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http://dx.doi.org/10.1186/s12929-019-0520-2DOI Listing

Sociodemographic inequities in cervical cancer screening, treatment and care amongst women aged at least 25 years: evidence from surveys in Harare, Zimbabwe.

BMC Public Health 2019 Apr 24;19(1):428. Epub 2019 Apr 24.

Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Background: Cervical cancer is the most commonly diagnosed cancer among women in Zimbabwe; however; access to screening and treatment services remain challenged. The objective of this study was to investigate socio-demographic inequities in cervical cancer screening and utilization of treatment among women in Harare, Zimbabwe.

Methods: Two cross sectional surveys were conducted in Harare with a total sample of 277 women aged at least 25 years. Read More

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http://dx.doi.org/10.1186/s12889-019-6749-6DOI Listing

Factors associated with low adherence to cervical cancer follow-up retest among HPV+/ cytology negative women: a study in programmatic context in a low-income population in Argentina.

BMC Cancer 2019 Apr 23;19(1):367. Epub 2019 Apr 23.

Centro de Estudios de Estado y Sociedad/Consejo Nacional de Investigaciones Científicas y Técnicas, Sánchez de Bustamante 27, Buenos Aires, Argentina.

Background: Cervical Cancer is still a major public health challenge in low and middle-income countries. HPV testing has been an innovative approach, which was introduced in Argentina for women aged 30+ through the Jujuy Demonstration Project (JDP) carried out between 2012 and 2014. After a positive HPV-test, cytology is used as triage method. Read More

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http://dx.doi.org/10.1186/s12885-019-5583-7DOI Listing

HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports.

BMC Cancer 2019 Apr 23;19(1):375. Epub 2019 Apr 23.

Department of Pathology, Institut Curie, 75005, Paris, France.

Background: Most endocervical adenocarcinomas are human papillomavirus (HPV)-related cancers associated with p16 immunostaining. Ovarian metastasis from cervical cancer is a rare phenomenon, the mechanism of dissemination remains unclear. The diagnosis of metastasis may be difficult to establish when the ovarian neoplasm presents features consistent with primary tumor. Read More

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http://dx.doi.org/10.1186/s12885-019-5582-8DOI Listing

[The indication and surgery scope for laparoscopic extraperitoneal lymphadenectomy in locally advanced cervical cancer].

Zhonghua Zhong Liu Za Zhi 2019 Apr;41(4):303-308

The Graduate Department, Jiangxi Medical College of Nanchang University, Nanchang 330006, China.

To explore the indication and surgery scope for laparoscopic extraperitoneal lymphadenectomy in locally advanced cervical cancer. Laparoscopic extraperitoneal lymphadenectomy was initially performed on patients with locally advanced cervical cancer. The results of preoperative computed tomography (CT) images and serum level of squamous cell carcinoma antigen (SCC-Ag) were analyzed, and the diagnostic efficiencies of the minimum axial diameter (MAD) of lymph node on CT≥0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.04.011DOI Listing

Enoxacin and Epigallocatechin Gallate (EGCG) Act Synergistically to Inhibit the Growth of Cervical Cancer Cells in Culture.

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

Department of Biology, Belmont University; 1900 Belmont Boulevard, Nashville, TN 37212, USA.

Cervical cancer is a major cause of death in females worldwide. While survival rates have historically improved, there remains a continuous need to identify novel molecules that are effective against this disease. Here, we show that enoxacin, a drug most commonly used to treat a broad array of bacterial infections, is able to inhibit growth of the cervical cancer cells. Read More

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http://dx.doi.org/10.3390/molecules24081580DOI Listing

Pancreatic Metastasis from Adenocarcinoma of the Uterine Cervix.

Korean J Gastroenterol 2019 Mar;73(3):182-185

, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.

Pancreatic metastasis from cervical cancer is extremely rare. We report a case of metastatic adenocarcinoma of the pancreas from uterine cervical cancer. A 70-year-old woman was referred because of a pancreatic mass detected by CT. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.3.182DOI Listing

Optimized Transferosomal Bovine Lactoferrin (BLF) as a Promising Novel Non-Invasive Topical Treatment for Genital Warts Caused by Human Papiluma Virus (HPV).

Iran J Pharm Res 2018 ;17(Suppl2):12-23

Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Human papillomavirus (HPV) cause common warts, laryngeal papilloma, and genital condylomata and might lead to development of cervical cancer. Lactoferrin (LF) is a member of the transferrin family, which has antiviral activity against HPV-16.  LF is an important player in the defense against pathogenic microorganisms and has also been shown to have activity against several viruses including herpesvirus, adenovirus, rotavirus, and poliovirus. Read More

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January 2018

The pattern of cell-to-cell transfer of microRNA by gap junction and its effect on the proliferation of glioma cells.

Cancer Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.

microRNA is expected to be a novel therapeutic tool for tumors. Gap junctions facilitate the transfer of microRNA, which exerts biological effects on tumor cells. However, the length of microRNA that can pass through certain gap junctions that are composed of specific connexin remains unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cas.14029
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http://dx.doi.org/10.1111/cas.14029DOI Listing
April 2019
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Pelvic exenteration as ultimate ratio for gynecologic cancers: single-center analyses of 37 cases.

Arch Gynecol Obstet 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, University of Ulm, Prittwitzstr. 43, 89075, Ulm, Germany.

Background: Pelvic exenterations are a last resort procedure for advanced gynecologic malignancies with elevated risks in terms of patients' morbidity.

Methods: This single-center analysis reports surgical details, outcome and survival of all patients treated with exenteration for non-ovarian gynecologic malignancies at our university hospital during a 13-year time period. We collected data regarding patients and tumor characteristics, surgical procedures, peri- and postoperative management, transfusions, complications, and analyzed the impact on survival outcomes. Read More

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http://dx.doi.org/10.1007/s00404-019-05154-4DOI Listing

The security of radical trachelectomy in the treatment of IA-IIA cervical carcinoma requires further evaluation: updated meta-analysis and trial sequential analysis.

Arch Gynecol Obstet 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, North Road of Workers Stadium, Chaoyang District, Beijing, 100020, China.

Purpose: The aim of this study was to assess the security of radical trachelectomy (RT) in the treatment of IA-IIA cervical carcinoma and conducted a new survey based upon the results of previous researches.

Methods: The PMC, PubMed, Web of Science, Cochrane and EMBASE databases were retrieved to collect prospective clinical controlled trials (CCTs) published from 1984 to 2018. The oncologic outcomes were evaluated by meta-analysis, trial sequence analysis (TSA) and statistical analysis. Read More

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http://link.springer.com/10.1007/s00404-019-05141-9
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http://dx.doi.org/10.1007/s00404-019-05141-9DOI Listing
April 2019
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Co-occurring substance use disorder: The impact on treatment adherence in women with locally advanced cervical cancer.

Gynecol Oncol Rep 2019 May 27;28:116-119. Epub 2019 Mar 27.

Virginia Commonwealth University Health System, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, United States of America.

The purpose of this study was to identify the prevalence of substance use disorder and its association with adherence to treatment and survival in locally advanced cervical cancer patients treated with primary radiation therapy. This is a retrospective case series of locally advanced cervical cancer patients with substance use disorder in a single academic institution treated with radiation therapy between 2005 and 2016. Substance use disorder was identified through chart review. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460223PMC

Therapeutic efficacy of a human papillomavirus type 16 E7 bacterial exotoxin fusion protein adjuvanted with CpG or GPI-0100 in a preclinical mouse model for HPV-associated disease.

Vaccine 2019 Apr 19. Epub 2019 Apr 19.

TheVax Genetics Vaccine Co., Ltd, Irvine, CA 92618, USA.

Persistent human papillomavirus (HPV) infection is causally linked to the development of several human cancers, including cervical, vulvar, vaginal, anal, penile, and oropharyngeal cancers. To address the need for a therapeutic vaccine against HPV-associated diseases, here we test and compare the immunogenicity and therapeutic efficacy of a bacterial exotoxin fusion protein covalently linked to the HPV16 E7 oncoprotein adjuvanted with CpG or GPI-0100 in the C3.43 preclinical HPV16-transformed tumor model. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.043DOI Listing

Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.

Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji, China.

Purpose: This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.

Materials And Methods: The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by Immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Read More

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http://www.e-crt.org/journal/view.php?doi=10.4143/crt.2018.5
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http://dx.doi.org/10.4143/crt.2018.544DOI Listing
April 2019
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The association between metformin therapy and risk of gynecological cancer in patients: Two meta-analyses.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:33-41. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.029DOI Listing

Development and Pilot Testing of an Assessment Tool for Performance of Invasive Mediastinal Staging.

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

Thoracic Surgery, University of Alberta.

Background: To develop and evaluate a surgical trainee competency assessment instrument for invasive mediastinal staging, including cervical mediastinoscopy and endobronchial ultrasound (EBUS), a comprehensive instrument was developed utilizing expert review and simulated and clinical pilot-testing: Thoracic Competency Assessment Tool-Invasive Staging (TCAT-IS).

Methods: Validity and reliability evidence was collected and item analysis was performed. Initially, a 27-item instrument was developed, which underwent expert review with members of the Canadian Association of Thoracic Surgeons (n=86) in 2014-2015 (response rate 57%). Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.050DOI Listing

Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature.

Case Rep Endocrinol 2019 17;2019:7964126. Epub 2019 Mar 17.

Division of Endocrinology, Diabetes & Metabolism, University of Illinois at Chicago, Chicago, IL, USA.

Objective: To present a rare case of malignant struma ovarii (MSO) and synchronous thyroid cancer, review the medical literature, and present the latest trends in management.

Methods: The case of a woman with MSO and concomitant thyroid cancer is presented, including clinical presentation, treatment, and follow-up care. A search of the English-language literature was conducted using MEDLINE and Google Scholar data bases. Read More

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http://dx.doi.org/10.1155/2019/7964126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441504PMC

Next generation sequencing driven successful combined treatment with laparoscopic surgery and immunotherapy for relapsed stage IVB cervical and synchronous stage IV lung cancer.

Oncotarget 2019 Mar 12;10(21):2012-2021. Epub 2019 Mar 12.

Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, Cagliari, Italy.

Background: The treatment of patients with multiple synchronous tumors is challenging and complex. The use of next generation sequencing (NGS) may help in identification of germline mutations in genes involved in a common etiology for both tumors thus allowing a common effective therapeutic strategy.

Patients And Methods: We describe the unexpected positive results obtained in a young woman with relapsed chemo-resistant stage IVB cervical and synchronous stage IV lung cancer, who underwent an interdisciplinary approach including palliative surgery with laparoscopic total pelvic exenteratio followed by a chemo-immunotherapy protocol with the anti-Programmed Death (PD)-1 antibody nivolumab plus metronomic cyclophosphamide. Read More

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http://dx.doi.org/10.18632/oncotarget.26769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459345PMC

Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study.

Infect Agent Cancer 2019 8;14. Epub 2019 Apr 8.

4Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne Cité, Paris, France.

We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0. Read More

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http://dx.doi.org/10.1186/s13027-019-0225-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454762PMC

The inhibition of miR-126 in cell migration and invasion of cervical cancer through regulating ZEB1.

Hereditas 2019 9;156:11. Epub 2019 Apr 9.

1Department of Gynaecology and Obstetrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing Medical University, No. 321 Zhongshan Road, Gulou District, Nanjing, 210008 Jiangsu China.

Background: Cervical cancer is a malignancy that's common in female with high incidence and mortality worldwide. MicroRNAs (miRNAs) act a pivotal part in human cancer development. Our aim was to investigate the effect of miR-126 on cervical cancer and its underlying molecular mechanism. Read More

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https://hereditasjournal.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s41065-019-0087-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456986PMC
April 2019
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Necessity of concurrent chemotherapy in N2-3 nasopharyngeal carcinoma treated with neoadjuvant chemotherapy of ≥3 cycles followed by intensity-modulated radiotherapy.

Cancer Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

Concurrent chemotherapy (CCT) is used in locally advanced nasopharyngeal carcinoma (NPC) for improved local control, which could also be achieved by intensity-modulated radiotherapy (IMRT). And for N2-3 NPC, distant metastasis is the more important cause of death. This study aims to evaluate the value of CCT in N2-3 NPC when neoadjuvant chemotherapy (NACT) of sufficient cycles is performed to eradicate distant metastasis. Read More

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http://dx.doi.org/10.1002/cam4.2179DOI Listing
April 2019
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Safety and effectiveness of robotic hysterectomy versus conventional laparoscopic hysterectomy in patients with cervical cancer in China.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynecology and Obstetrics, Gansu Provincial Hospital, No. 204, West Donggang Road, Lanzhou, 730000, People's Republic of China.

Objective: The aim of this study was to compare the safety and effectiveness of robotic hysterectomy (RH) with conventional laparoscopic hysterectomy (LH) for the treatment of cervical cancer using multivariate regressions.

Methods: We designed a retrospective single-center study and consecutively collected patients with cervical cancer from February 2014 to October 2017. Data extraction was performed by two independent researchers. Read More

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http://link.springer.com/10.1007/s00404-019-05148-2
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http://dx.doi.org/10.1007/s00404-019-05148-2DOI Listing
April 2019
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Hidden blood loss and its risk factors in patients undergoing laparoscopy and laparotomy for cervical cancer management.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynaecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

Purpose: Laparoscopy and laparotomy are the two most common surgical options used to treat women with early-stage cervical cancer. This study aimed to examine the volume of hidden blood loss (HBL) between laparoscopy and laparotomy for cervical cancer and to identify its risk factors.

Methods: Sixty-one patients treated with laparotomy and 50 patients treated with laparoscopy were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00404-019-05162-4DOI Listing

A GCIG international survey: clinical practice patterns of sentinel lymph node biopsies in cervical cancer.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynecology With Center for Oncological Surgery, Charité Universtitätmedizin, Charité Platz 1, 10117, Berlin, Germany.

Purpose: To evaluate the practice patterns among centers and physicians worldwide regarding sentinel lymph node biopsies (SLNB) in cervical cancer (CC) patients.

Method: A validated 35-item questionnaire regarding SLNB in CC supported by the Gynecologic Cancer Intergroup (GCIG), and sponsored by the North-Eastern German Society of Gynaecologic-Oncology (NOGGO) was sent to all major gynecological cancer societies across the globe for further distribution from October 2015 and continued for a period of 7 months.

Results: One hundred and sixty-one institutions from around the world participated. Read More

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http://link.springer.com/10.1007/s00404-019-05164-2
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http://dx.doi.org/10.1007/s00404-019-05164-2DOI Listing
April 2019
2 Reads