168 results match your criteria Cerebrovascular diseases extra[Journal]


High White Blood Cell Count Is a Risk Factor for Contrast-Induced Nephropathy following Mechanical Thrombectomy for Acute Ischemic Stroke.

Cerebrovasc Dis Extra 2020 Jul 1;10(2):59-65. Epub 2020 Jul 1.

Department of Neurology, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Background: Although mechanical thrombectomy is a standard endovascular therapy for patients with acute ischemic stroke (AIS), the incidence of and risk factors for contrast-induced nephropathy (CIN) following mechanical thrombectomy are infrequently reported.

Objectives: The aim of this study was to investigate the incidence and risk factors for CIN following mechanical thrombectomy for AIS, and whether the incidence of CIN is related to a poor prognosis.

Methods: We examined consecutive patients who underwent a mechanical thrombectomy in the period from January 2014 to March 2018. Read More

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http://dx.doi.org/10.1159/000507918DOI Listing

Efficacy and Safety of Endovascular Treatment in Acute Tandem Carotid Occlusions: Analysis of a Single-Center Cohort.

Cerebrovasc Dis Extra 2020 Jun 24;10(2):50-58. Epub 2020 Jun 24.

Service of Neurology, University Hospital "Central de Asturias" and ISPA, Oviedo, Spain,

Introduction: Acute ischemic strokes with tandem occlusions, which represent 10-20% of all ischemic strokes, have a particularly poor prognosis. Since emergent treatment of tandem lesions has not been specifically addressed in randomized trials, there is an absence of standardized management.

Objective: We sought to assess the efficacy and safety of acute endovascular treatment in stroke due to tandem occlusions in our center and compare the results with previous reports. Read More

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http://dx.doi.org/10.1159/000507919DOI Listing

Rates and Determinants for the Use of Anticoagulation Treatment before Stroke in Patients with Known Atrial Fibrillation.

Cerebrovasc Dis Extra 2020 May 6;10(2):44-49. Epub 2020 May 6.

Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy.

Introduction And Objective: Even though the introduction of less cumbersome anticoagulant agents has improved, the rates ofoverall anticoagulant treatment in eligible patients with atrial fibrillation (AF) remain to be defined. We aimed to assess the rates of and determinants for the use of anticoagulation treatment before stroke in patients with known AF since the introduction of direct oral anticoagulants (DOAC) in clinical practice.

Methods: Consecutive patients admitted to an individual stroke unit, from September 2013 through July 2019, for acute ischemic stroke or transient ischemic attack (TIA) with known AF before the event were included in the study. Read More

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http://dx.doi.org/10.1159/000506923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250375PMC

The Hyperdense Middle Cerebral Artery Sign in Drip-and-Ship Models of Acute Stroke Management.

Cerebrovasc Dis Extra 2020 28;10(1):36-43. Epub 2020 Apr 28.

Department of Neurology, Erasme Hospital, ULB, Brussels, Belgium.

Background: Large vessel occlusion (LVO) leads to debilitating stroke and responds modestly to recombinant tissue plasminogen activator (rt-TPA). Early thrombectomy improves functional outcomes in selected patients with proximal occlusion but it is not available in all medical facilities. The best imaging modality for triage in an acute stroke setting in drip-and-ship models is still the subject of debate. Read More

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http://dx.doi.org/10.1159/000506971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289154PMC

Does Intravenous Thrombolysis Influence the Time of Recanalization and Success of Mechanical Thrombectomy during the Acute Phase of Cerebral Infarction?

Cerebrovasc Dis Extra 2020 28;10(1):28-35. Epub 2020 Apr 28.

Interventional Neuroradiology department, Besançon University Hospital, Besançon, France.

Objectives: Mechanical thrombectomy (MT) is an effective treatment for acute ischemic stroke (AIS) caused by large vessel occlusion. Recanalization time is a key factor in the treatment of AIS. It has previously been suggested that intravenous thrombolysis (IVT) may be associated with a shorter recanalization time. Read More

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http://dx.doi.org/10.1159/000507119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289153PMC

Cognitive Impairment Correlates Linearly with Mean Flow Velocity by Transcranial Doppler below a Definable Threshold.

Cerebrovasc Dis Extra 2020 14;10(1):21-27. Epub 2020 Apr 14.

University of Alabama at Birmingham, Birmingham, Alabama, USA.

Introduction: Low cerebral blood flow can affect cognition in patients with high-grade asymptomatic internal carotid artery stenosis. Current clinical algorithms use stroke risk to determine which patients should undergo revascularization without considering cognitive decline. Although correlations between low-flow and cognitive impairment have been reported, it is not known whether a threshold exists below which such a correlation expresses itself. Read More

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http://dx.doi.org/10.1159/000506924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289156PMC

Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study.

Cerebrovasc Dis Extra 2020 6;10(1):11-20. Epub 2020 Feb 6.

Department of Neurology, Oslo University Hospital, Oslo, Norway.

Background And Purpose: Cardioembolic stroke due to paroxysmal atrial fibrillation (AF) may account for 1 out of 4 cryptogenic strokes (CS) and transient ischemic attacks (TIAs). The purpose of this pilot study was to search for biomarkers potentially predicting incident AF in patients with ischemic stroke or TIA.

Methods: Plasma samples were collected from patients aged 18 years and older with ischemic stroke or TIA due to AF (n = 9) and large artery atherosclerosis (LAA) with ipsilateral carotid stenosis (n = 8) and age- and sex-matched controls (n = 10). Read More

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http://dx.doi.org/10.1159/000504529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036587PMC

Weather Fluctuations May Have an Impact on Stroke Occurrence in a Society: A Population-Based Cohort Study.

Cerebrovasc Dis Extra 2020 5;10(1):1-10. Epub 2020 Feb 5.

Department of Emergency and Disaster Medicine, Gifu University, Gifu, Japan.

Background: Stroke has been found to have a seasonally varying incidence; blood pressure, one of its risk factors, is influenced by humidity and temperature. The relationship between the incidence of stroke and meteorological parameters remains controversial.

Objective: We investigated whether meteorological conditions are significant risk factors for stroke, focusing on the fluctuation of weather elements that triggers the onset of stroke. Read More

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http://dx.doi.org/10.1159/000505122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036586PMC

Comparison of ABC Methods with Computerized Estimates of Intracerebral Hemorrhage Volume: The INTERACT2 Study.

Cerebrovasc Dis Extra 2019 13;9(3):148-154. Epub 2019 Dec 13.

The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia,

Background And Purpose: Hematoma volume is a key determinant of outcome in acute intracerebral hemorrhage (ICH). We aimed to compare estimates of ICH volume between simple (ABC/2, length, width, and height) and gold standard planimetric software approaches.

Methods: Data are from the second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Read More

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http://dx.doi.org/10.1159/000504531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940457PMC

Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population.

Cerebrovasc Dis Extra 2019 12;9(3):139-147. Epub 2019 Dec 12.

Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA,

Background And Purpose: Cerebral microbleeds (CMB) are reported to be frequent in moyamoya disease (MMD) and moyamoya syndrome (MMS) in the Asian population. It is associated with an increased risk of intracerebral hemorrhage. The significance of CMB in MMD/MMS in non-Asian populations has not been well established. Read More

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http://dx.doi.org/10.1159/000504530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940455PMC

Active Cancer and Elevated D-Dimer Are Risk Factors for In-Hospital Ischemic Stroke.

Cerebrovasc Dis Extra 2019 22;9(3):129-138. Epub 2019 Nov 22.

Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

Background And Purpose: Little attention has been paid to the pathogenesis of in-hospital stroke, despite poor outcomes and a longer time from stroke onset to treatment. We studied the pathophysiology and biomarkers for detecting patients who progress to in-hospital ischemic stroke (IHS).

Methods: Seventy-nine patients with IHS were sequentially recruited in the period 2011-2017. Read More

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http://dx.doi.org/10.1159/000504163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940458PMC

Infarct Patterns in Patients with Atherosclerotic Vertebrobasilar Disease in Relation to Hemodynamics.

Cerebrovasc Dis Extra 2019 16;9(3):123-128. Epub 2019 Oct 16.

Department of Neurosurgery, University of Illinois, Chicago, Illinois, USA,

Introduction: Distal territory blood flow is independently associated with subsequent strokes in symptomatic vertebrobasilar atherosclerotic disease. We aimed to assess infarct patterns in relation to hemodynamic status in the prospective Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) study.

Methods: Distal territory blood flow was measured using quantitative magnetic resonance angiography (MRA) in 72 patients with symptomatic atherosclerotic vertebrobasilar disease, and then dichotomized into normal (n = 54) and low (n = 18) flow. Read More

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http://dx.doi.org/10.1159/000503091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873055PMC
May 2020
1 Read

Pattern Recognition to Identify Stroke in the Cognitive Profile: Secondary Analyses of a Prospective Cohort Study.

Cerebrovasc Dis Extra 2019 8;9(3):114-122. Epub 2019 Oct 8.

Program in Public Health and Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.

Background: Stroke can produce subtle changes in the brain that may produce symptoms that are too small to lead to a diagnosis. Noting that a lack of diagnosis may bias research estimates, the current study sought to examine the utility of pattern recognition relying on serial assessments of cognition to objectively identify stroke-like patterns of cognitive decline (pattern-detected stroke, p-stroke).

Methods: Secondary data analysis was conducted using participants with no reported history of stroke in the Health and Retirement Study, a large (n = 16,113) epidemiological study of cognitive aging among respondents aged 50 years and older that measured episodic memory consistently biennially between 1996 and 2014. Read More

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http://dx.doi.org/10.1159/000503002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873083PMC

Factors Associated with Unsuccessful Recanalization in Mechanical Thrombectomy for Acute Ischemic Stroke.

Cerebrovasc Dis Extra 2019 27;9(3):107-113. Epub 2019 Sep 27.

Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan.

Introduction: Mechanical thrombectomy (MT) for acute ischemic stroke has become a standard therapy, and the recanalization rate has significantly improved. However, some cases of unsuccessful recanalization still occur. We aimed to clarify patient factors associated with unsuccessful recanalization after MT for acute ischemic stroke. Read More

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http://dx.doi.org/10.1159/000503001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792430PMC
May 2020
1 Read

Usefulness of Transesophageal Echocardiography for Predicting Covert Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source.

Cerebrovasc Dis Extra 2019 20;9(3):98-106. Epub 2019 Sep 20.

Department of Cerebrovascular Medicine, Stroke Center, Steel Memorial Yawata Hospital, Kitakyushu, Japan.

Background: Covert paroxysmal atrial fibrillation (CPAF) is a major cause of embolic stroke of undetermined source (ESUS). However, detecting PAF during hospitalization in these patients is difficult.

Objectives: This study aimed to determine whether findings of transesophageal echocardiography (TEE) during hospitalization are associated with later detection of PAF in patients with ESUS. Read More

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http://dx.doi.org/10.1159/000502713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787416PMC

Acute Stroke Treatment in Patients with Basilar Artery Occlusion: A Single-Center Observational Study.

Cerebrovasc Dis Extra 2019 29;9(2):90-97. Epub 2019 Aug 29.

Stroke Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy,

Background: Acute ischemic stroke (AIS) due to basilar artery occlusion (BAO) represents 1-4% of all ischemic strokes. BAO results in strokes associated with a high risk of a poor functional outcome and, in 86-95% of the untreated cases, it results in death because of the vital cerebral structures involved. Diagnosis can be delayed because of the variability in presenting symptoms, and acute treatment is often attempted even beyond 6 h from symptoms onset because of the high risk of a fatal prognosis. Read More

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http://dx.doi.org/10.1159/000502084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787421PMC
February 2020
2 Reads

Effectiveness of Combined External Ventricular Drainage with Intraventricular Fibrinolysis for the Treatment of Intraventricular Haemorrhage with Acute Obstructive Hydrocephalus.

Cerebrovasc Dis Extra 2019 13;9(2):77-89. Epub 2019 Aug 13.

Department of Neurology, Bach Mai Hospital, Hanoi, Vietnam.

Background: Intraventricular haemorrhage (IVH) patients with acute obstructive hydrocephalus (AOH) who require external ventricular drainage (EVD) are at high risk for poor outcomes. Intraventricular fibrinolysis (IVF) with low-dose recombinant tissue plasminogen activator (rtPA) can be used to improve patient outcomes. Here, we evaluated the impact of IVF on the risk of death and the functional outcomes in IVH patients with AOH. Read More

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http://dx.doi.org/10.1159/000501530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751468PMC
February 2020
2 Reads

Subject Retention in Prehospital Stroke Research Using a Telephone-Based Physician-Investigator Driven Enrollment Method.

Cerebrovasc Dis Extra 2019 25;9(2):72-76. Epub 2019 Jul 25.

Keck School of Medicine, Department of Neurology, University of Southern California, Los Angeles, California, USA.

Background And Purpose: Subject retention into clinical trials is vital, and prehospital enrollment may be associated with higher rates of subject withdrawal than more traditional methods of enrollment. We describe rates of subject retention in a prehospital trial of acute stroke therapy.

Methods: All subjects were enrolled into the NIH Field Administration of Stroke Therapy-Magnesium (FAST-MAG) phase 3 clinical trial. Read More

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http://dx.doi.org/10.1159/000500851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738216PMC
February 2020
3 Reads

"Weekend Effect" on 30-Day Readmissions among Stroke Survivors: An Analysis of the National Readmission Database.

Cerebrovasc Dis Extra 2019 24;9(2):66-71. Epub 2019 Jun 24.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA,

Background And Purpose: Previous studies suggested that quality of care may be lower on weekends than during the week. We hypothesized that, among patients hospitalized for an index ischemic stroke, those admitted on weekends would have a higher risk of 30-day readmission than those admitted on weekdays.

Methods: We utilized the 2013 Nationwide Readmission Database, which includes data on US inpatient admissions from the Agency for Healthcare Research and Quality Healthcare Utilization Project. Read More

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http://dx.doi.org/10.1159/000500611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036528PMC
February 2020
17 Reads

Microbleeds after Carotid Artery Stenting: Small Embolism May Induce Cerebral Microbleeds.

Cerebrovasc Dis Extra 2019 14;9(2):57-65. Epub 2019 Jun 14.

Department of Neurology, Mie University Graduate School of Medicine, Tsu, Japan.

Background: Since the advent of magnetic resonance imaging technology, cerebral microbleeds can be diagnosed in vivo. However, the underlying mechanism of cerebral microbleed formation is not fully understood.

Objectives: This study aimed to identify the factors associated with cerebral microbleeds after carotid artery stenting (CAS). Read More

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http://dx.doi.org/10.1159/000500112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600049PMC
February 2020
1 Read

Stent Retriever Thrombectomy Potentially Increases the Recanalization Rate, Improves Clinical Outcome, and Decreases Mortality in Acute Basilar Occlusion: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis Extra 2019 5;9(2):46-56. Epub 2019 Jun 5.

Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany,

Background: Acute basilar artery occlusion (BAO) is a devastating condition if untreated. The optimal treatment strategy, however, is unknown. Historically, interventional approaches have been favored over intravenous thrombolysis (IVT), although this is not supported by good evidence. Read More

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http://dx.doi.org/10.1159/000499665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587203PMC
February 2020
3 Reads

Nonsteroidal Anti-Inflammatory Drugs: A Potential Pharmacological Treatment for Intracranial Aneurysm.

Cerebrovasc Dis Extra 2019 30;9(1):31-45. Epub 2019 Apr 30.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA.

Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated with high morbidity and mortality. Surgical interventions, such as clipping and coiling, have associated risks. Read More

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http://dx.doi.org/10.1159/000499077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036563PMC
February 2020
3 Reads

Cardiac Magnetic Resonance Imaging in Patients with Acute Ischemic Stroke and Elevated Troponin: A TRoponin ELevation in Acute Ischemic Stroke (TRELAS) Sub-Study.

Cerebrovasc Dis Extra 2019 30;9(1):19-24. Epub 2019 Apr 30.

Department of Cardiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

Background: Elevated high-sensitive cardiac troponin (hs-cTn) can be found in more than 50% of the patients with acute ischemic stroke. The observational TRoponin ELevation in Acute ischemic Stroke (TRELAS) study revealed that about 25% of all stroke patients with elevated troponin had a coronary angiography-detected culprit lesion affording immediate intervention, and about 50% of all patients did not have any obstructive coronary artery disease. Given the risk of procedure-related complications, the identification of stroke patients in urgent need of invasive coronary angiography is desirable. Read More

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http://dx.doi.org/10.1159/000498864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528079PMC
February 2020
3 Reads

Increased Plasma VEGF Levels in Patients with Cerebral Large Artery Disease Are Associated with Cerebral Microbleeds.

Cerebrovasc Dis Extra 2019 30;9(1):25-30. Epub 2019 Apr 30.

Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan,

Background/purpose: Because atherosclerotic factors and antithrombotic agents sometimes induce cerebral microbleeds (CMBs), patients with cerebral large artery disease (CLAD) tend to have more CMBs than control subjects. On the other hand, VEGF contributes to the disruption of the blood-brain barrier, and it may induce parenchymal edema and bleeding. We conducted a study to evaluate the role of vascular endothelial growth factor (VEGF) in the occurrence of CMBs in patients with CLAD. Read More

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http://dx.doi.org/10.1159/000497215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528098PMC
February 2020
2 Reads

Circulating Microparticles in Patients with Symptomatic Carotid Disease Are Related to Embolic Plaque Activity and Recent Cerebral Ischaemia.

Cerebrovasc Dis Extra 2019 3;9(1):9-18. Epub 2019 Apr 3.

Radiological Sciences in the Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom.

Background And Purpose: In order to assess the association of microparticles derived from activated platelets (PMP) or endothelial cells (EMP) with risk markers for recurrent embolic events in patients with symptomatic carotid artery disease, we studied the associations between PMP/EMP and three risk markers: plaque haemorrhage (PH), micro-embolic signals and cerebral diffusion abnormalities.

Methods: Patients with recently symptomatic high-grade carotid artery stenosis (60-99%, 42 patients, 31 men; mean age 75 ± 8 years) and 30 healthy volunteers (HV, 11 men; mean age 56 ± 12 years) were prospectively recruited. Patients were characterised by carotid magnetic resonance imaging (presence of PH [MRI PH]), brain diffusion MRI (cerebral ischaemia [DWI+]) and transcranial Doppler ultrasound (micro-embolic signals [MES+]). Read More

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http://dx.doi.org/10.1159/000495942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489022PMC
February 2020
6 Reads

Health Economic Evaluations of Digital Health Interventions for Secondary Prevention in Stroke Patients: A Systematic Review.

Cerebrovasc Dis Extra 2019 7;9(1):1-8. Epub 2019 Jan 7.

Vrije Universiteit Brussel (VUB), Interuniversity Center for Health Economics Research (I-CHER), Brussels, Belgium.

Background: In the first 5 years after their stroke, about a quarter of patients will suffer from a recurrent stroke. Digital health interventions facilitating interactions between a caregiver and a patient from a distance are a promising approach to improve patient adherence to lifestyle changes proposed by secondary prevention guidelines. Many of these interventions are not implemented in daily practice, even though efficacy has been shown. Read More

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http://dx.doi.org/10.1159/000496107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489060PMC
February 2020
1 Read

Transient Ischaemic Attack Rarely Precedes Stroke in a Cohort with Low Proportions of Large Artery Atherosclerosis: A Population-Based Study.

Cerebrovasc Dis Extra 2018 23;8(2):101-105. Epub 2018 Aug 23.

Stroke and Neurology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Background: Ischaemic stroke is reportedly preceded by transient ischaemic attack (TIA) in 15-30% of all cases. The risk of stroke following TIA is highest in the presence of unstable atherosclerotic plaques in large arteries. The recent population-based Adelaide Stroke Incidence Study describes a population with a low proportion (16%) of stroke attributable to large artery atherosclerosis (LAA). Read More

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http://dx.doi.org/10.1159/000491936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120413PMC
October 2018
6 Reads

A Novel Intraoperative Laser Light Imaging System to Simultaneously Visualize Visible Light and Near-Infrared Fluorescence for Indocyanine Green Videoangiography.

Cerebrovasc Dis Extra 2018 27;8(2):96-100. Epub 2018 Jul 27.

Department of Neurosurgery, Fukushima Medical University, Fukushima, Japan.

Background: Intraoperative indocyanine green videoangiography (ICG-VA) has been reported to be utilized in various cerebrovascular surgeries, wherein the blood flow is noticeably shown in white with a black background. ICG flow alone, but not other structures, can be observed using ICG-VA. We developed a novel high-resolution intraoperative imaging system using laser light source for simultaneously visualizing both visible light and near-infrared (NIR) fluorescence images of ICG-VA. Read More

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http://dx.doi.org/10.1159/000490872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120366PMC
October 2018
2 Reads

Effect of Exercise on Physical Recovery of People with Locked-In Syndrome after Stroke: What Do We Know from the Current Evidence? A Systematic Review.

Cerebrovasc Dis Extra 2018 13;8(2):90-95. Epub 2018 Jul 13.

Jockey Club Intergenerational Art Centre, Tung Wah Group of Hospitals, Hong Kong SAR, China.

Introduction: Locked-in syndrome (LIS) results from a brainstem lesion in the pons. Ischemic stroke is the most common etiology of LIS. People with LIS have poor mobility with serious complications due to immobilization. Read More

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http://dx.doi.org/10.1159/000490312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489030PMC
October 2018
39 Reads

Cerebral Haemodynamics following Acute Ischaemic Stroke: Effects of Stroke Severity and Stroke Subtype.

Cerebrovasc Dis Extra 2018 11;8(2):80-89. Epub 2018 Jul 11.

Neurology Department, Hospital das Clinicas, School of Medicine, University of São Paulo, São Paulo, Brazil.

Background: Acute ischaemic stroke (AIS) patients often show impaired cerebral autoregulation (CA). We tested the hypothesis that CA impairment and other alterations in cerebral haemodynamics are associated with stroke subtype and severity.

Methods: AIS patients (n = 143) were amalgamated from similar studies. Read More

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http://dx.doi.org/10.1159/000487514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489023PMC
October 2018
3 Reads

Stroke Mortality in Kenya's Public Tertiary Hospitals: A Prospective Facility-Based Study.

Cerebrovasc Dis Extra 2018 12;8(2):70-79. Epub 2018 Jun 12.

Maine Medical Center Research Institute, Portland, Maine, USA.

Background: Despite the increasing global burden of stroke, there are limited data on stroke from Kenya to guide in decision-making. Stroke occurrence in sub-Saharan Africa has been associated with poor health outcomes. This study sought to establish the stroke incidence density and mortality in Kenya's leading public tertiary hospitals for purposes of informing clinical practice and policy. Read More

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http://dx.doi.org/10.1159/000488205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031945PMC
October 2018
13 Reads

Predictors of Cardioembolic Stroke in Japanese Patients with Atrial Fibrillation in the Fushimi AF Registry.

Cerebrovasc Dis Extra 2018 22;8(2):50-59. Epub 2018 May 22.

Department of Neurosurgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Background: Large-scale clinical trials have analyzed risk factors for any ischemic stroke in patients with atrial fibrillation (AF). However, the risk factors for cardioembolic stroke (CES), specifically, have not been reported. To clarify the risk factors for CES and clinically significant cardioembolic infarction, we examined the incidence of CES and larger infarct volume (IV) (> 30 mL) CES, employing the Fushimi AF Registry, a community-based prospective cohort of AF patients in the Fushimi ward, Kyoto, Japan. Read More

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http://dx.doi.org/10.1159/000488206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006634PMC
October 2018
16 Reads

Knowledge about Stroke in Belo Horizonte, Brazil: A Community-Based Study Using an Innovative Video Approach.

Cerebrovasc Dis Extra 2018 22;8(2):60-69. Epub 2018 May 22.

Universidade Federal de São Paulo, São Paulo, Brazil.

Background And Purpose: Stroke is a leading cause of death in Brazil. Knowledge about the clinical manifestations of stroke as well as its risk factors and its management is still poor in the country. We intended to assess the stroke knowledge of an urban population in Belo Ho-rizonte, Brazil. Read More

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https://www.karger.com/Article/FullText/488400
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http://dx.doi.org/10.1159/000488400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006611PMC
October 2018
38 Reads

Oral Health and Brain Injury: Causal or Casual Relation?

Cerebrovasc Dis Extra 2018 9;8(1):1-15. Epub 2018 Jan 9.

Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University, Hammel, Denmark.

Background: To systematically review the current literature investigating the association between oral health and acquired brain injury.

Methods: A structured search strategy was applied to PubMed, Embase, Web of Science, and CENTRAL electronic databases until March 2017 by 2 independent reviewers. The preferred reporting items for systematic review and meta-analysis guidelines were used for systematic review. Read More

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http://dx.doi.org/10.1159/000484989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836263PMC
September 2018
2 Reads

Intracranial Arterial Calcification in Black Africans with Acute Ischaemic Stroke.

Cerebrovasc Dis Extra 2018 15;8(1):26-38. Epub 2018 Jan 15.

Background: Intracranial arterial calcification (IAC), a recognized marker of atherosclerosis on cranial computed tomography (CT), is an independent risk factor for ischaemic stroke. This study aimed to determine the prevalence, distribution, severity, and associations of IAC in adults with acute ischaemic stroke (AIS) at the University College Hospital, Ibadan, Nigeria.

Methods: Cranial CT images of 130 consecutive adults who presented with AIS were acquired on a 64-slice multi-detector Toshiba Aquilion scanner and evaluated for IAC in bone window on Vitrea® software using a semi-quantitative scoring method for extent, thickness, and length of calcifications in the large intracranial arteries. Read More

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http://dx.doi.org/10.1159/000485195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836175PMC
September 2018
6 Reads

Erythrocyte-Rich Thrombus Is Associated with Reduced Number of Maneuvers and Procedure Time in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy.

Cerebrovasc Dis Extra 2018 15;8(1):39-49. Epub 2018 Jan 15.

Department of Neurosurgery, Ise Red Cross Hospital, Ise City, Japan.

Background: Only few studies have investigated the relationship between the histopathology of retrieved thrombi and clinical outcomes. This study aimed to evaluate thrombus composition and its association with clinical, laboratory, and neurointerventional findings in patients treated by mechanical thrombectomy due to acute large vessel occlusion.

Methods: At our institution, 79 patients were treated by mechanical thrombectomy using a stent retriever and/or aspiration catheter between August 2015 and August 2016. Read More

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http://dx.doi.org/10.1159/000486042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836222PMC
September 2018
25 Reads

Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms.

Cerebrovasc Dis Extra 2018 15;8(1):16-25. Epub 2018 Jan 15.

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Background: Echolucent carotid plaques have been related to an increased risk of ischemic cerebrovascular events. The aim of the present study was to evaluate whether a new objective ultrasonographic parameter, the statistical geometric feature (SGF), reflecting spottiness of carotid plaques, can be associated with cerebrovascular symptoms and with a rupture-prone plaque phenotype.

Methods: The plaques of 144 patients who underwent carotid endarterectomy were included in this study. Read More

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http://dx.doi.org/10.1159/000485258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836198PMC
September 2018
4 Reads

Frequency, Aetiology, and Outcome of Small Cerebellar Infarction.

Cerebrovasc Dis Extra 2017 2;7(3):173-180. Epub 2017 Nov 2.

Department of Neurology and Neurophysiology, Liverpool Hospital, Liverpool, New South Wales, Australia.

Background And Purpose: Strokes due to small (<2 cm) cerebellar infarction are under-recognised, and their profile and aetiology have not been well characterised. We aimed to determine the frequency, clinical features, aetiology, and outcome of small as compared to large cerebellar infarction.

Methods: This study is a retrospective analysis of clinical and imaging features of a prospectively assessed series of 108 consecutive patients with acute cerebellar infarction admitted to Liverpool Hospital, Sydney, NSW, Australia, during 2011-2015. Read More

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https://www.karger.com/Article/FullText/481459
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http://dx.doi.org/10.1159/000481459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731170PMC
July 2018
9 Reads

Characteristics and Outcomes of Vertebrobasilar Artery Dissection with Accompanied Atherosclerosis.

Cerebrovasc Dis Extra 2017 17;7(3):165-172. Epub 2017 Oct 17.

Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: With the popularity of MRI use, vertebrobasilar artery dissection (VBD) has been found more frequently in patients with posterior circulation ischemic stroke (PCS). The relationship between VBD and atherosclerosis is unknown. The present study aimed to prove the hypothesis that PCS with pure VBD (p-VBD) and with VBD and accompanied cervical or cerebral artery atherosclerosis (a-VBD) have distinct manifestations. Read More

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http://dx.doi.org/10.1159/000480523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731180PMC
July 2018
6 Reads

Improvement and Aggravation of Spontaneous Unruptured Vertebral Artery Dissection.

Cerebrovasc Dis Extra 2017 17;7(3):153-164. Epub 2017 Oct 17.

Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, Kyushu Medical Center, Fukuoka, Japan.

Background: Intracranial vertebral artery dissection (VAD) is a well-recognized cause of stroke in young and middle-aged individuals, especially in Asian populations. However, a long-term natural course remains unclear. We investigated the long-term time course of VAD using imaging findings to examine the rate and predisposing factors for improvement. Read More

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http://dx.doi.org/10.1159/000481442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731136PMC
July 2018
68 Reads

The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study.

Cerebrovasc Dis Extra 2017 10;7(3):140-152. Epub 2017 Oct 10.

Alzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands.

Background: Hemodynamic balance in the heart-brain axis is increasingly recognized as a crucial factor in maintaining functional and structural integrity of the brain and thereby cognitive functioning. Patients with heart failure (HF), carotid occlusive disease (COD), and vascular cognitive impairment (VCI) present themselves with complaints attributed to specific parts of the heart-brain axis, but hemodynamic changes often go beyond the part of the axis for which they primarily seek medical advice. The Heart-Brain Study hypothesizes that the hemodynamic status of the heart and the brain is an important but underestimated cause of VCI. Read More

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http://dx.doi.org/10.1159/000480738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730112PMC
July 2018
43 Reads

Pharyngolaryngeal Sensory Deficits in Patients with Middle Cerebral Artery Infarction: Lateralization and Relation to Overall Dysphagia Severity.

Cerebrovasc Dis Extra 2017 3;7(3):130-139. Epub 2017 Oct 3.

Department of Neurology, University Hospital Münster, Münster, Germany.

Background: Dysphagia is a frequent and dangerous complication of acute stroke. Apart from a well-timed oropharyngeal muscular contraction pattern, sensory feedback is of utmost importance for safe and efficient swallowing. In the present study, we therefore analyzed the relation between pharyngolaryngeal sensory deficits and post-stroke dysphagia (PSD) severity in a cohort of acute stroke patients with middle cerebral artery (MCA) infarction. Read More

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https://www.karger.com/Article/FullText/479483
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http://dx.doi.org/10.1159/000479483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730110PMC
July 2018
28 Reads

Abbreviation of the Follow-Up NIH Stroke Scale Using Factor Analysis.

Cerebrovasc Dis Extra 2017 2;7(3):120-129. Epub 2017 Oct 2.

Background: The NIH Stroke Scale (NIHSS) is a 15-item measure of stroke-related neurologic deficits that, when measured at 24 h, is highly predictive of long-term functional outcome. We hypothesized that a simplified 24-h scale that incorporates the most predictive components of the NIHSS can retain prognostic accuracy and have improved interrater reliability.

Methods: In a post hoc analysis of the Interventional Management of Stroke-3 (IMS-3) trial, we performed principal component (PC) analysis to resolve the 24-h NIHSS into PCs. Read More

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http://dx.doi.org/10.1159/000479933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730111PMC
July 2018
31 Reads

In Potential Stroke Patients on Warfarin, the International Normalized Ratio Predicts Ischemia.

Cerebrovasc Dis Extra 2017 11;7(2):111-119. Epub 2017 Aug 11.

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Background: Stroke can occur in patients on warfarin despite anticoagulation. Patients with a low international normalized ratio (INR) should theoretically be at greater risk for ischemia than those who are therapeutic. Therefore, INR may be able to indicate whether new neurological deficits are more likely strokes or stroke mimics in patients on warfarin. Read More

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http://dx.doi.org/10.1159/000478793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618398PMC

Dosage Calculation for Intravenous Thrombolysis of Ischemic Stroke: To Weigh or to Estimate.

Cerebrovasc Dis Extra 2017 30;7(2):103-110. Epub 2017 May 30.

Department of Neurology, Saarland University Medical Center, Homburg, Germany.

Background: Estimation is a widely used method of assessing the weight of patients with acute stroke. Because the dosage of tissue plasminogen activator (tPA) is weight-dependent, errors in estimation lead to incorrect dosing.

Methods: We installed a ground-level scale in the computed tomography (CT) suite of our hospital and also integrated a scale into the CT table of our Mobile Stroke Unit in order to prospectively assess the differences between reported, estimated, and measured weights of acute stroke patients. Read More

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http://dx.doi.org/10.1159/000474955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471779PMC
May 2018
12 Reads

Outcomes of Endovascular Thrombectomy with and without Thrombolysis for Acute Large Artery Ischaemic Stroke at a Tertiary Stroke Centre.

Cerebrovasc Dis Extra 2017 2;7(2):95-102. Epub 2017 May 2.

Department of Neurology, Sir Charles Gairdner Hospital, Perth, Washington, Australia.

Background And Purpose: Endovascular thrombectomy (EVT) improves the functional outcome when added to best medical therapy, including alteplase, in patients with acute ischaemic stroke secondary to large vessel occlusion (LVO) in the anterior circulation. However, the evidence for EVT in alteplase-ineligible patients is less compelling. It is also uncertain whether alteplase is necessary in patients with successful recanalization by EVT, as the treatment effect of EVT may be so powerful that bridging alteplase may not add to efficacy and may compromise safety by increasing bleeding risks. Read More

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http://dx.doi.org/10.1159/000470855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685497PMC
May 2018
29 Reads

Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study.

Cerebrovasc Dis Extra 2017 21;7(1):84-94. Epub 2017 Apr 21.

Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.

Background: Coagulation factor XII (FXII) is involved in pathological thrombus formation and is a suggested target of anticoagulants. It is unclear whether FXII levels are correlated with cardiovascular risk factors and whether they are associated with myocardial infarction or ischemic or hemorrhagic stroke. The aim of this study was to investigate the correlation between FXII and cardiovascular risk factors in the general population. Read More

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http://dx.doi.org/10.1159/000468994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437482PMC
January 2018
12 Reads

Blunt Traumatic Extracranial Cerebrovascular Injury and Ischemic Stroke.

Cerebrovasc Dis Extra 2017 11;7(1):72-83. Epub 2017 Apr 11.

Background: Ischemic stroke occurs in a significant subset of patients with blunt traumatic cerebrovascular injury (TCVI). The patients are victims of motor vehicle crashes, assaults or other high-energy collisions, and suffer ischemic stroke due to injury to the extracranial carotid or vertebral arteries.

Summary: An increasing number of patients with TCVI are being identified, largely because of the expanding use of computed tomography angiography for screening patients with blunt trauma. Read More

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https://www.karger.com/Article/FullText/455391
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http://dx.doi.org/10.1159/000455391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425764PMC
January 2018
5 Reads

Volume and Characteristics of Intracerebral Hemorrhage with Direct Oral Anticoagulants in Comparison with Warfarin
.

Cerebrovasc Dis Extra 2017 3;7(1):62-71. Epub 2017 Apr 3.

Department of Neurosurgery, Saiseikai Misumi Hospital, Uki-city, Japan.

Background: Patients undergoing anticoagulation therapy often experience intracerebral hemorrhages (ICHs), and warfarin in particular is known to increase hematoma expansion in ICHs, which results in a poor outcome. Recent studies reported that, in comparison with warfarin, direct oral anticoagulants (DOACs) cause fewer ICHs with better functional outcome. However, since it is still unknown whether DOACs are associated with a smaller hematoma volume of ICHs, we aimed to compare the volume, hematoma expansion, and outcomes associated with ICHs treated with DOACs and warfarin. Read More

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http://dx.doi.org/10.1159/000462985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425761PMC
January 2018
11 Reads

High Risk of Seizures and Epilepsy after Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Stroke
.

Cerebrovasc Dis Extra 2017 30;7(1):51-61. Epub 2017 Mar 30.

Postgraduate Program in Medicine: Medical Science, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Decompressive hemicraniectomy (DHC) is a life-saving procedure for treatment of large malignant middle cerebral artery (MCA) strokes. Post-stroke epilepsy is an additional burden for these patients, but its incidence and the risk factors for its development have been poorly investigated.

Objective: To report the prevalence and risk factors for post-stroke seizures and post-stroke epilepsy after DHC for treatment of large malignant MCA strokes in a cohort of 36 patients. Read More

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http://dx.doi.org/10.1159/000458730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425760PMC
January 2018
9 Reads