140,892 results match your criteria Cerebrovascular diseases Basel Switzerland[Journal]


Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats.

Brain Res 2020 Jul 6:147007. Epub 2020 Jul 6.

Programa de Pós-graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, 96210-900, Brazil; Laboratório de Histologia, FURG, Rio Grande, RS, 96210-900, Brazil; Laboratório de Neurociências, Instituto de Ciências Biológicas, FURG, Rio Grande, RS, 96210-900, Brazil.

Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A limiting factor when considering therapies for the nervous tissue is the presence of the blood-brain barrier which stimulates the search for new drug delivery strategies. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147007DOI Listing

Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description.

Brain 2020 Jul 9. Epub 2020 Jul 9.

Department of Neurology, Hospital General Universitario de Albacete, Albacete, Spain.

Since the appearance of the first case of coronavirus disease 2019 (COVID-19) a pandemic has emerged affecting millions of people worldwide. Although the main clinical manifestations are respiratory, an increase in neurological conditions, specifically acute cerebrovascular disease, has been detected. We present cerebrovascular disease case incidence in hospitalized patients with SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.1093/brain/awaa239DOI Listing

Clinical characteristics of 82 cases of death from COVID-19.

PLoS One 2020 9;15(7):e0235458. Epub 2020 Jul 9.

Department of Oncology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.

A recently developed pneumonia caused by SARS-CoV-2 bursting in Wuhan, China, has quickly spread across the world. We report the clinical characteristics of 82 cases of death from COVID-19 in a single center. Clinical data on 82 death cases laboratory-confirmed as SARS-CoV-2 infection were obtained from a Wuhan local hospital's electronic medical records according to previously designed standardized data collection forms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235458PLOS

Disease assimilation: The mortality impacts of fine particulate matter on immigrants to Canada.

Health Rep 2020 Jun;31(3):14-26

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia.

Background: Immigrants make up 20% of the Canadian population; however, little is known about the mortality impacts of fine particulate matter (PM) air pollution on immigrants compared with non-immigrants, or about how impacts may change with duration in Canada.

Data And Methods: This study used the 2001 Canadian Census Health and Environment Cohort, a longitudinal cohort of 3.5 million individuals, of which 764,000 were classified as immigrants (foreign-born). Read More

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http://dx.doi.org/10.25318/82-003-x202000300002-engDOI Listing

A tale of two arteries: dual posterior cerebral arteries with vascular bridges. A possible protective pattern?

Authors:
Y Mansour R Kulesza

Folia Morphol (Warsz) 2020 Jul 9. Epub 2020 Jul 9.

Department of Anatomy, Lake Erie College of Osteopathic Medicine, Erie, PA, United States.

Stroke is a common morbidity and a frequent cause of disability and even death. The impact of cerebrovascular events are dictated by the brain region involved and can be complicated by anatomical variations. One of the most common variations impacting the cerebrovasculature is the presence of a fetal posterior cerebral artery. Read More

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http://dx.doi.org/10.5603/FM.a2020.0070DOI Listing

Cure or curd: Modification of lipid profiles and cardio-cerebrovascular events after hepatitis C virus eradication.

Kaohsiung J Med Sci 2020 Jul 9. Epub 2020 Jul 9.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Hepatitis C virus (HCV) eradication deteriorates lipid profiles. Although HCV eradication may reduce the risk of vascular events as a whole, whether deteriorated lipid profiles increases the risk of cardio-cerebral disease in certain patients is elusive. Serial lipid profiles were measured before, during, at and 3 months after the end of direct-acting antivirals (DAAs) therapy, and annually thereafter in chronic hepatitis C patients who achieved a sustained virological response (SVR, undetectable HCV RNA at posttreatment week 12). Read More

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http://dx.doi.org/10.1002/kjm2.12275DOI Listing

Transient Global Amnesia - Risk Factors and Putative Background.

Neurol India 2020 May-Jun;68(3):624-629

Department of Neurology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Objectives: Transient global amnesia (TGA) is a temporary short-term reversible memory loss. Etiology of TGA remains unclear with various hypotheses. We analyzed clinical characteristics, neuroimaging, and electrophysiological findings as well as comorbidities and seasonal variation in TGA patients with regard to possible background of the syndrome. Read More

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http://dx.doi.org/10.4103/0028-3886.288979DOI Listing

Tissue oxygenation indices of cerebrovascular autoregulation in healthy volunteers: a comparison of two NIRS devices.

Neurol Res 2020 Jul 9:1-7. Epub 2020 Jul 9.

South Western Sydney Clinical School, University of New South Wales , Sydney, Australia.

Background: Correlation coefficients between blood pressure and cerebral oxygen saturation measured using near-infrared spectrometry may be used to derive the tissue oximetry index of cerebral autoregulation. Cerebral oxygen saturations demonstrate poor agreement between near-infrared spectrometers however it is unclear if measurements of autoregulation are similarly specific to the equipment used.

Methods: Cerebral oxygen saturation was monitored bilaterally in 74 healthy volunteers using both the FORE-SIGHT and EQUANOX monitors in random order. Read More

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http://dx.doi.org/10.1080/01616412.2020.1790869DOI Listing

Prognostic Factors and Outcomes in Young Patients With Presented of Different Types Acute Coronary Syndrome.

Angiology 2020 Jul 9:3319720939444. Epub 2020 Jul 9.

Department of Cardiology, Sakarya University Education and Research Hospital, Sakarya, Turkey.

The prevalence of coronary artery disease is increasing in young adults. We evaluated the outcomes of different types of acute coronary syndrome in 917 patients undergoing coronary angiography aged ≤45 years. Male sex, smoking, dyslipidemia were the most important risk factors. Read More

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http://dx.doi.org/10.1177/0003319720939444DOI Listing

Management of cardiovascular comorbidities in chronic obstructive pulmonary disease patients.

J Thorac Dis 2020 May;12(5):2791-2802

WHO Global Coordination Mechanism for NCD Prevention and Control, WHO, Geneva, Switzerland.

Chronic obstructive pulmonary disease (COPD) is а highly prevalent, complex and heterogeneous clinical condition which is associated with significant concomitant diseases. COPD and cardiovascular diseases (CVDs) often coexist due to the high prevalence of each of these pathological conditions separately as well as the common risk factors (particularly smoking), mechanisms of interaction and influence of systemic inflammation. In addition, decreased pulmonary function in COPD is closely associated with an increased risk of congestive CVDs. Read More

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http://dx.doi.org/10.21037/jtd.2020.03.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330365PMC

Kupffer cells promote T-cell hepatitis by producing CXCL10 and limiting liver sinusoidal endothelial cell permeability.

Theranostics 2020 1;10(16):7163-7177. Epub 2020 Jun 1.

Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.

Kupffer cells (KCs) play a crucial role in liver immune homeostasis through interacting with other immune cells and liver sinusoidal endothelial cells (LSECs). However, how KCs exactly interact with these cells for maintaining the homeostasis still require the further investigation. CXCL10 is a chemokine that has been implicated in chemoattraction of monocytes, T cells, NK cells, and dendritic cells, and promotion of T cell adhesion to endothelial cells. Read More

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http://dx.doi.org/10.7150/thno.44960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330839PMC

Impaired occipital cerebrovascular reactivity as a biomarker for vascular β-amyloid.

Neurology 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology, ASST San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000010207DOI Listing

Relationship between blood pressure and outcome changes over time in acute ischemic stroke.

Neurology 2020 Jul 8. Epub 2020 Jul 8.

From the Seoul National University College of Medicine, Seoul, Korea (J.-A.S.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea (K.-J.L., J.H.K., B.J.K., M.-K.H., J.Y.K., M.S.J., M.H.Y., H.-J.B.); Department of Biostatistics, Korea University, Seoul (J.L.); Clinical Research Center, Asan Medical Center, Seoul (J.S.L.). Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (PBG)

Objective: To evaluate whether the relationship between systolic blood pressure (SBP) and stroke outcome varies during the acute stage of ischemic stroke as a function of the elapsed time after stroke onset.

Methods: Patients who were hospitalized due to ischemic stroke within 6 h of onset were retrospectively analyzed. SBP data were collected at eight time-points (1, 2, 4, 8, 16, 24, 48, and 72 h post-onset). Read More

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http://dx.doi.org/10.1212/WNL.0000000000010203DOI Listing

Cerebrovascular reactivity in cerebral amyloid angiopathy, Alzheimer disease, and mild cognitive impairment.

Neurology 2020 Jul 8. Epub 2020 Jul 8.

Department of Clinical Neurosciences, University of Calgary, Calgary, Canada

Objective: To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer's disease (AD), and mild cognitive impairment (MCI) using functional magnetic resonance imaging (fMRI).

Methods: Prospective cohort study including 40 CAA, 22 AD, 27 MCI, and 25 healthy controls. Each participant underwent a visual fMRI task using a contrast-reversing checkerboard stimulus. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010201DOI Listing

Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders.

Stroke Vasc Neurol 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, China

Aim: Stroke is characterised by high morbidity, mortality and disability, which seriously affects the health and safety of the people. Stroke has become a serious public health problem in China. Organisational stroke management can significantly reduce the mortality and disability rates of patients with stroke. Read More

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http://dx.doi.org/10.1136/svn-2020-000355DOI Listing

Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients.

Mol Brain 2020 Jul 8;13(1):102. Epub 2020 Jul 8.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.

Parkinson's disease (PD) is the second most common neurodegenerative disease, and mild cognitive impairment (MCI) is a well-established risk factor for the development of dementia in PD. A growing body of evidence suggests that low expression of glucocerebrosidase (GBA) promotes the transmission of α-synuclein (α-Syn) interpolymers and the progression of PD. However, how GBA mutations affect the pathogenesis of PD via abnormal aggregation of α-Syn is unclear, and no clinically valid PD-MCI genetic markers have been identified. Read More

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http://dx.doi.org/10.1186/s13041-020-00637-xDOI Listing

Modifiable Risk Factors Associated With Moyamoya Disease: A Case-Control Study.

Stroke 2020 Jul 9:STROKEAHA120030027. Epub 2020 Jul 9.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China (P.G., Q.Z., X.Y., X.L., X.D., J.W., R.W., Y.Z., D.Z., J.Z.).

Background And Purpose: The cause of moyamoya disease (MMD) remains unknown. We aimed to investigate the association between modifiable risk factors and MMD in a prospective, case-control study.

Methods: Clinical and laboratory characteristics were evaluated in consecutively recruited adult patients with MMD and age-matched healthy control individuals. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.030027DOI Listing

Novel Noncrossing Y-Stent Technique Using Tapered Proximal End of a Solitaire AB Stent for Coil Embolization of Wide-Neck Bifurcation Aneurysms.

J Korean Neurosurg Soc 2020 Jul 9. Epub 2020 Jul 9.

Department of Neurosurgery, Daejeon-Chungnam Regional Cerebrovascular Center, Chungnam National University Hospital, Chungnam National University Medical School, Daejeon, Korea.

The crossing Y-stent method is one of the indispensable techniques to achieve sufficient neck coverage during coil embolization of bifurcation aneurysms with a wide neck and/or branch incorporation. However, the inevitable hourglass-like expansion of the second stent at the crossing point can result in insufficient vessel wall apposition, reduced aneurysm neck coverage, delayed endothelialization, and subsequent higher risks of acute or delayed thrombosis. It also interferes with engagement of the microcatheter into the aneurysm after stent installation. Read More

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http://dx.doi.org/10.3340/jkns.2019.0253DOI Listing

Specific differences and responses to reductions for premature mortality attributable to ambient PM in China.

Sci Total Environ 2020 Jun 30;742:140643. Epub 2020 Jun 30.

National Research Base of Intelligent Manufacturing Service, Chongqing Technology and Business University, Chongqing 400067, China.

Although recent assessments have quantified the impact of ambient PM on public health in China, air quality managers would benefit from assessing specific differences in premature mortality and its responses to air quality improvement. Using PM data simulated by an observation-fused air quality model and an integrated exposure-response model for the full range of PM, we determined the premature mortality attributable to ambient PM across mainland China in 2016. Overall, the total number of PM-related deaths nationwide was 1. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140643DOI Listing

Long-term outcome of prosthesis-patient mismatch after transcatheter aortic valve replacement.

Int J Cardiol 2020 Jul 5. Epub 2020 Jul 5.

Interventional Cardiology Unit, Cardio-Thoracic-Vascular Department, University Hospital of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy. Electronic address:

Background: Incidence and long-term clinical consequences of prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) are still unclear.

Methods: We enrolled 710 consecutive patients who underwent TAVR. PPM was defined as absent if the index orifice area (iEOA) was >0. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.033DOI Listing

Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry.

Hypertension 2020 08 8;76(2):545-553. Epub 2020 Jul 8.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium (M.P., S.D.M., A. Pasquet, A. Persu).

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15349DOI Listing

One year follow-up Assessment of Patients Included in the Brazilian Registry of Acute Coronary Syndromes (ACCEPT).

Arq Bras Cardiol 2020 Jun 29;114(6):995-1003. Epub 2020 Jun 29.

Instituto de Cardiologia, Fundação Universitária de Cardiologia do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Background There is lack of prospective data on evolution within one year of acute coronary syndromes (ACS) in a representative population of Brazilian patients. Objectives To assess the prescription of evidence-based therapies, the incidence of severe outcomes and the predictors for these outcomes in a multicenter Brazilian registry of ACS patients. Methods The ACCEPT is a prospective observational study, which included patients hospitalized with a diagnostic of ACS in 47 Brazilian hospitals. Read More

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http://dx.doi.org/10.36660/abc.20190879DOI Listing

Worse prognosis in women, compared with men, after thrombolysis: An individual patient data pooling study of Asian acute stroke registries.

Int J Stroke 2020 Jul 8:1747493020938307. Epub 2020 Jul 8.

The George Institute for Global Health, University of New South Wales, NSW, Australia.

Background And Purpose: To examine sex differences in disease profiles and short-term outcomes after acute ischemic stroke treated with recombinant tissue plasminogen activator.

Methods: Eight national and regional stroke registries contributed individual participant data from mainland China, Japan, Philippines, Singapore, South Korea and Taiwan in 2005-2018. The primary outcome was ordinal-modified Rankin scale at 90 days. Read More

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http://dx.doi.org/10.1177/1747493020938307DOI Listing

Enhancing and accelerating stroke treatment in Eastern European region: Methods and achievement of the ESO EAST program.

Eur Stroke J 2020 Jun 20;5(2):204-212. Epub 2020 Jan 20.

Department of Neurology, Med Campus III, Kepler University Hospital, Linz, Austria.

Introduction: Despite the availability of prevention and therapies of stroke, their implementation in clinical practice, even of low-cost ones, remains poor. In 2015, the European Stroke Organisation (ESO) initiated the ESO Enhancing and Accelerating Stroke Treatment (EAST) program, which aims to improve stroke care quality, primarily in Eastern Europe. Here, we describe its methods and milestones. Read More

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http://dx.doi.org/10.1177/2396987319897156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313365PMC

SiPP (Stroke in Pregnancy and Postpartum): A prospective, observational, international, multicentre study on pathophysiological mechanisms, clinical profile, management and outcome of cerebrovascular diseases in pregnant and postpartum women.

Eur Stroke J 2020 Jun 6;5(2):193-203. Epub 2019 Dec 6.

Department of Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.

Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn.

Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients, their predictors and infant outcome.

Methods And Design: This is an observational, prospective, multicentre, international case-control study. Read More

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http://dx.doi.org/10.1177/2396987319893512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313370PMC

Sex Dimorphisms in Ischemic Stroke: From Experimental Studies to Clinic.

Front Neurol 2020 19;11:504. Epub 2020 Jun 19.

Brain and Nerve Research Laboratory, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Sex dimorphisms are important factors that influence the outcomes after ischemic stroke, which include basic health status, cerebrovascular anatomy, hormone levels, and unique factors such as pregnancy and menopause. It is widely recognized that male and female respond differently to stroke. Women aged 45-74 years old showed a lower risk of stroke incidence compared to age-matched man. Read More

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http://dx.doi.org/10.3389/fneur.2020.00504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318992PMC

Mesial bifrontal stroke presenting as isolated spontaneous confabulations.

Pract Neurol 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

A 52-year-old man with paroxysmal atrial fibrillation presented with spontaneous confabulation, working memory deficits, and frontal release signs. MR scan of brain showed bifrontal mesial ischaemic strokes and angiography demonstrated that both anterior cerebral arteries were supplied by the left internal carotid artery. Isolated spontaneous confabulation is a rare presentation of stroke and may be associated with orbitofrontal cortex lesions. Read More

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http://dx.doi.org/10.1136/practneurol-2020-002518DOI Listing

Low C4 as a risk factor for severe neuropsychiatric flare in patients with systemic lupus erythematosus.

Lupus 2020 Jul 7:961203320938453. Epub 2020 Jul 7.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE).

Methods: This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP flare was defined as the occurrence of at least one newly developed British Isles Lupus Assessment Group A score in the neurological domain. Read More

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http://dx.doi.org/10.1177/0961203320938453DOI Listing

Five-Year Cumulative Cost Saving with Thrombolysis in Korea: 3-Month Disability-Based Estimation.

J Stroke 2020 May 31;22(2):262-265. Epub 2020 May 31.

Department of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

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http://dx.doi.org/10.5853/jos.2020.00556DOI Listing

Outcome of Stroke Patients with Cancer and Nonbacterial Thrombotic Endocarditis.

J Stroke 2020 May 31;22(2):245-253. Epub 2020 May 31.

Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Background And Purpose: Nonbacterial thrombotic endocarditis (NBTE) is a cause of stroke in cancer. However, clinical characteristics and outcomes in stroke patients with cancer-associated NBTE are not well known.

Methods: We included consecutive patients with stroke and active cancer over a 9-year period who underwent echocardiography. Read More

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http://dx.doi.org/10.5853/jos.2020.00619DOI Listing

Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers.

J Clin Med 2020 Jul 4;9(7). Epub 2020 Jul 4.

Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), E15706 Santiago de Compostela, Spain.

Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Read More

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http://dx.doi.org/10.3390/jcm9072108DOI Listing

COVID-19 and Stroke: Casual or Causal Role?

Cerebrovasc Dis 2020 Jul 7:1-4. Epub 2020 Jul 7.

UTN (Neurovascular Therapy Unit), F. Spaziani Hospital, Frosinone, Italy.

Background: The COVID-19 outbreak is currently the major public health concern worldwide. This infection, caused by the novel coronavirus Sars Cov2, primarily affects respiratory system, but there is increasing evidence of neurologic involvement and cerebrovascular accidents.

Case Report: We present a case of stroke in a 62-year-old COVID-19-positive patient, with multiple vascular risk factors. Read More

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http://dx.doi.org/10.1159/000509453DOI Listing

Quantification of brain oxygen extraction and metabolism with [O]-gas PET: A technical review in the era of PET/MRI.

Neuroimage 2020 Jul 4:117136. Epub 2020 Jul 4.

Department of Radiology, Stanford University, Stanford CA, USA.

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117136DOI Listing

Results of the surgical management of acute limb ischemia in the nonagenarians.

Ann Vasc Surg 2020 Jul 4. Epub 2020 Jul 4.

Service de Chirurgie vasculaire, CHU Besançon, France; EA3920, Université de Franche-Comté, CHU Besançon, France. Electronic address:

Background: The aging of the population leads us to treat older patients, in particular presenting with acute limb ischemia (ALI). However there has been little evaluation of this pathology in the nonagenarians. The objectives of this work were thus to evaluate the one-month and one-year mortality of the nonagenarians treated for ALI, which made possible to determine the one-year survival and to highlight the factors influencing the mortality. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.05.073DOI Listing

Extracranial ectasia and embolic infarcts in HIV: two case reports and a clinical decision-making algorithm.

J Neurovirol 2020 Jul 6. Epub 2020 Jul 6.

Departments of Neurology, Veterans Affairs Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

HIV is known to increase the risk of both ischemic and hemorrhagic strokes. There are many postulated mechanisms for this elevated risk including an HIV-induced vasculopathy and/or coagulopathy, opportunistic infections, and cardioembolic etiologies, among others. Regarding vasculopathy, prior reports have described the various changes to the arterial vasculature that can occur in the setting of HIV, yet the appropriate workup and management of this condition remains poorly defined. Read More

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http://dx.doi.org/10.1007/s13365-020-00867-8DOI Listing

De Novo Assembly and Annotation of the Juvenile Tuber Transcriptome of a Gastrodia elata Hybrid by RNA Sequencing: Detection of SSR Markers.

Biochem Genet 2020 Jul 6. Epub 2020 Jul 6.

Department of Field Crops, Faculty of Agricultural and Natural Sciences, Abant İzzet Baysal University, Bolu, Turkey.

Gastrodia elata is a traditional Chinese herbal medicine with good therapeutic effect on various nervous and cerebrovascular diseases. In the present study, we generated 20,611,556 raw reads from the young tuber transcriptome of a G. elata hybrid (Gastrodia elata BI. Read More

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http://dx.doi.org/10.1007/s10528-020-09983-wDOI Listing

Relationship between motoric cognitive risk syndrome, cardiovascular risk factors and diseases, and incident cognitive impairment: Results from the "NuAge" study.

Maturitas 2020 Aug 16;138:51-57. Epub 2020 May 16.

Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland.

Background: Motoric Cognitive Risk syndrome (MCR), which combines Subjective Cognitive Complaint (SCC) and slow gait speed in individuals free of dementia and gait disability, is associated with cardiovascular risk factors and diseases as well as incident cognitive impairment. Little information on MCR exists in the Canadian population. This study aims to examine these associations in community-dwelling elderly people living in Quebec, which is a Canadian province. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.007DOI Listing

Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage.

Acta Neuropathol Commun 2020 Jul 6;8(1):99. Epub 2020 Jul 6.

Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β (Aβ) protein in the cerebral vasculature and poses a major risk factor for the development of intracerebral haemorrhages (ICH). However, only a minority of patients with CAA develops ICH (CAA-ICH), and to date it is unclear which mechanisms determine why some patients with CAA are more susceptible to haemorrhage than others. We hypothesized that an imbalance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) contributes to vessel wall weakening. Read More

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http://dx.doi.org/10.1186/s40478-020-00972-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336459PMC

Prior bariatric surgery and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus: hint from National Inpatient Sample Database.

Cardiovasc Diabetol 2020 Jul 6;19(1):103. Epub 2020 Jul 6.

Department of Endocrinology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhong Shan Er Lu, Guangzhou, 510080, China.

Background: Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus (T2DM).

Methods: We used the National Inpatient Sample Database to identify T2DM patients undergoing major noncardiac surgery from 2006 to 2014. Read More

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http://dx.doi.org/10.1186/s12933-020-01084-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339406PMC

Renal resistive index and long-term outcome in patients with coronary artery disease.

BMC Cardiovasc Disord 2020 Jul 6;20(1):322. Epub 2020 Jul 6.

First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 47 Ziołowa St., 40-635, Katowice, Poland.

Background: The study aimed to evaluate the application of intra-renal Doppler flow indices for the prediction of major adverse cardiac and cerebrovascular events (MACCE) during 24-month follow-up in patients with coronary artery disease (CAD) subject to coronary angiography (CA).

Methods: This prospective study comprised 111 consecutive patients with stable and unstable CAD (68.5% men; median age 65 years), referred for CA. Read More

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http://dx.doi.org/10.1186/s12872-020-01607-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339420PMC

Microecological treatment of hyperuricemia using Lactobacillus from pickles.

BMC Microbiol 2020 Jul 6;20(1):195. Epub 2020 Jul 6.

Department of LiWan Hospital, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.

Background: Hyperuricemia is one of the important risk factors for gout, arteriosclerosis, cardiovascular and cerebrovascular disease. Lactobacillus has attracted much attention due to its role in the regulation of intestinal function and tumor resistance, but its ability to reduce uric acid is unclear. Pickles are a traditional fermented food rich in lactic acid bacteria (LAB). Read More

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http://dx.doi.org/10.1186/s12866-020-01874-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336419PMC

Atrial Fibrillation on Patients with Vascular Dementia: A Fundamental Target for Correct Management.

Brain Sci 2020 Jul 2;10(7). Epub 2020 Jul 2.

Neurological Clinic, Marche Polytechnic University, 60020 Ancona, Italy.

Background: Atrial fibrillation (AF) is a risk factor for cerebrovascular diseases and vascular dementia (VAD). The aim of this study was to evaluate the effect of the adherence to anticoagulant therapy guidelines in patients with dementia and AF on the risk of stroke/TIA or major bleeding (MB).

Methods: In a cohort of 1705 hospitalized patients with pre-existent AF, we observed 193 patients with vascular dementia (VAD). Read More

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http://dx.doi.org/10.3390/brainsci10070420DOI Listing

Cerebral carbon dioxide embolism after kidney cancer laparoscopic surgery with full neurological recovery: A case report.

Medicine (Baltimore) 2020 Jul;99(27):e20986

Department of Radiology, Peking University Third Hospital, Haidian District.

Rationale: Cerebral carbon dioxide embolism (CCDE) is a rare cause of stroke and is a recognized life-threatening complication.CCDE may result from direct intravascular CO2 insufflation during surgery. Due to the lack of typical clinical manifestations, the disease is often missed or mistaken for another condition. Read More

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http://dx.doi.org/10.1097/MD.0000000000020986DOI Listing
July 2020
5.723 Impact Factor

Association of trimethylamine N-oxide with coronary atherosclerotic burden in patients with non-ST-segment elevation myocardial infarction.

Medicine (Baltimore) 2020 Jul;99(27):e20794

Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen.

Background: Recently, trimethylamine N-oxide (TMAO) unexplained gut microbe has been proposed as a promising risk factor for atherosclerotic cardiovascular disease (CVD) pathogenesis and adverse events. The relationship of TMAO with coronary atherosclerotic burden has been evaluated in patients with stable coronary artery disease and ST-segment elevation myocardial infarction, but still needs to be explored in newly diagnosed non-ST-segment elevation myocardial infarction (NSTEMI) patients.

Material And Methods: A prospective, single-center, SZ-NSTEMI trial (ChiCTR1900022366) is underway to investigate the relationship of TMAO with the severity and prognosis of coronary atherosclerosis in newly diagnosed NSTEMI patients who will undergo coronary angiography with primary percutaneous coronary intervention (pPCI). Read More

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http://dx.doi.org/10.1097/MD.0000000000020794DOI Listing

[Investigation on the awareness of snoring hazard and prevalence of obstructive sleep apnea among civil servants].

Zhonghua Jie He He Hu Xi Za Zhi 2020 Jul;43(7):553-556

Sleep Center, Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences/Guangdong Provincial Geriatrics Institute, Guangzhou 510080, China.

To investigate the awareness of snoring hazard and prevalence of obstructive sleep apnea (OSA) among civil servants. A cross-sectional survey was conducted to investigate the awareness of snoring hazards among in-service civil servants who had annual medical examination in a Guangdong provincial institution from September to November 2017. The high-risk group for OSA was screened and diagnosed by sleep monitoring. Read More

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http://dx.doi.org/10.3760/cma.j.cn112147-20191013-00682DOI Listing