3,086 results match your criteria Cerebrovascular Diseases[Journal]


Reduced Hypoxic Tissue and Cognitive Improvement after Revascularization Surgery for Chronic Cerebral Ischemia.

Cerebrovasc Dis 2019 Feb 15;47(1-2):57-64. Epub 2019 Feb 15.

Department of Neurosurgery, Iwate Medical University, Morioka,

Background: Hypoxic but viable neural tissue is seen on 1-(2-18F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (18F-FRP170) positron emission tomography (PET) in patients with chronic cerebral ischemia with a combination of misery perfusion and moderately reduced oxygen metabolism. Cognitive function sometimes improves after revascularization surgery in patients with chronic cerebral ischemia.

Objectives: We used brain perfusion single-photon emission computed tomography (SPECT) and 18F-FRP170 PET to determine whether hypoxic tissue was reduced following the restoration of cerebral perfusion after carotid endarterectomy (CEA) in patients with severe stenosis of the cervical internal carotid artery (ICA) and whether the reduction in hypoxic tissue was associated with cognitive improvement. Read More

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http://dx.doi.org/10.1159/000497244DOI Listing
February 2019

Renal Impairment Is Associated with Intracerebral Hemorrhage after Mechanical Thrombectomy in Vertebrobasilar Stroke.

Cerebrovasc Dis 2019 Feb 15;47(1-2):48-56. Epub 2019 Feb 15.

Department of Neurology, Heidelberg University Hospital, Heidelberg,

Background And Purpose: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far.

Materials And Methods: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed. Read More

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http://dx.doi.org/10.1159/000497070DOI Listing
February 2019

Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.

Cerebrovasc Dis 2019 Feb 14;47(1-2):24-31. Epub 2019 Feb 14.

Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial.

Methods: Subjects in the SAMMPRIS trial were included in this study. Read More

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http://dx.doi.org/10.1159/000497245DOI Listing
February 2019

Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients.

Cerebrovasc Dis 2019 Feb 14;47(1-2):32-39. Epub 2019 Feb 14.

Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of

Background: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. Read More

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http://dx.doi.org/10.1159/000497069DOI Listing
February 2019
1 Read

One-Year Risk of Recurrent Stroke and Death Associated with Vertebrobasilar Artery Stenosis and Occlusion in a Cohort of 10,515 Patients.

Cerebrovasc Dis 2019 Feb 14;47(1-2):40-47. Epub 2019 Feb 14.

College of Medicine, China Medical University, Taichung, Taiwan.

Background: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied.

Methods: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation. Read More

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http://dx.doi.org/10.1159/000495418DOI Listing
February 2019
1 Read

Associations of High Intensities on Magnetization-Prepared Rapid Acquisition with Gradient Echo with Aortic Complicated Lesions in Ischemic Stroke Patients.

Cerebrovasc Dis 2019 Feb 14;47(1-2):15-23. Epub 2019 Feb 14.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Background: Aortic complicated lesions (ACLs) are key parameters for evaluating aortic embolic sources in embolic stroke, and are usually diagnosed using transesophageal echocardiography (TEE). However, alternative methods for diagnosing ACLs have not been well established. We investigated associations between high-intensity areas on T1-weighted imaging (T1WI) with magnetization-prepared rapid acquisition with gradient echo (MPRAGE) and ACLs on TEE among ischemic stroke patients. Read More

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http://dx.doi.org/10.1159/000497068DOI Listing
February 2019

Using the Region of Interest from Time-of-Flight Magnetic Resonance Angiography to Differentiate Between Intracranial Arterial Dissection and True Atherosclerotic Stenosis.

Cerebrovasc Dis 2019 Feb 6;47(1-2):8-14. Epub 2019 Feb 6.

Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of

Background: Noncontrast three-dimensional time-of-flight magnetic resonance angiography (3D TOF MRA) is commonly used to examine intracranial arterial stenosis, although it can be difficult to identify the etiology of the stenosis. Our aim was to determine the effectiveness of 3D TOF MRA in differentiating an intracranial arterial dissection from atherosclerosis.

Methods: During 2015-2017, 356 patients had confirmed intracranial arterial stenosis based on high resolution-magnetic resonance imaging. Read More

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https://www.karger.com/Article/FullText/496505
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http://dx.doi.org/10.1159/000496505DOI Listing
February 2019
2 Reads
3.754 Impact Factor

European Stroke Conference. 27th Conference, Athens, Greece, April 11-13, 2018.

Authors:

Cerebrovasc Dis 2018 28;45 Suppl 1:I-II. Epub 2018 May 28.

Click here for the free "http://misc.karger.com/websites/CED_2018_045_S1/index. Read More

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http://dx.doi.org/10.1159/000490132DOI Listing

Risks of Acute Stroke Treatment in Patients with Cardiac Disease.

Cerebrovasc Dis 2018 18;46(5-6). Epub 2019 Jan 18.

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http://dx.doi.org/10.1159/000496627DOI Listing
January 2019
1 Read

Returning to Unpaid Work after Stroke: The Psychosocial Outcomes in Stroke Cohort Study.

Cerebrovasc Dis 2019 Jan 17;47(1-2):1-7. Epub 2019 Jan 17.

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Background: While returning to paid work is a crucial marker of stroke recovery, little is known about the differences in unpaid work by sex following stroke. We aimed to determine the sex differences in participation in unpaid work 12 months after stroke.

Methods: Psychosocial outcomes in stroke were a prospective, multicentre observational study that recruited individuals, 18-64 years, within 28 days of stroke from New South Wales, Australia. Read More

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http://dx.doi.org/10.1159/000496399DOI Listing
January 2019
1 Read

The Relationship between Blood Pressure Variability, Recanalization Degree, and Clinical Outcome in Large Vessel Occlusive Stroke after an Intra-Arterial Thrombectomy.

Cerebrovasc Dis 2018 15;46(5-6):279-286. Epub 2019 Jan 15.

Department of Neurology, Seoul National University College of Medicine, Seoul National University Bun-Dang Hospital, Seongnam, Republic of

Background: Blood pressure variability (BPV) is associated with target organ damage progression and increased cardiovascular events, including stroke. The aim of this study was to evaluate the associations between short-term BPV during acute periods and recanalization degree, early neurological deterioration (END) occurrence, and functional outcomes in acute ischemic stroke patients who had undergone intra-arterial thrombectomy (IAT).

Methods: We retrospectively analyzed 303 patients with large vessel occlusive stroke who underwent IAT. Read More

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http://dx.doi.org/10.1159/000495300DOI Listing
January 2019
2 Reads

Intra-Plaque Vessels on Contrast-Enhanced Ultrasound Sonography Predict Carotid Plaque Histology.

Cerebrovasc Dis 2018 15;46(5-6):265-269. Epub 2019 Jan 15.

Department of Neurosurgery, Fukuoka University, Fukuoka, Japan.

Background And Purpose: Although the echogenicity of carotid plaques on carotid enhanced ultrasound (CEUS) was reported to correlate with the historological density of intra-plaque neovessels, it is unclear whether the intra-plaque vessel size is associated with carotid plaque vulnerability. We evaluated the relationship of size of intra-plaque vessels on CEUS with carotid plaque histology.

Methods: We prospectively registered patients with carotid stenosis who were hospitalized to receive carotid endarterectomy between 2012 and 2016. Read More

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http://dx.doi.org/10.1159/000495299DOI Listing
January 2019
2 Reads

Thrombus Enhancement Is a Predictor of Clinical Outcome in Acute Ischemic Stroke after Mechanical Thrombectomy.

Cerebrovasc Dis 2018 15;46(5-6):270-278. Epub 2019 Jan 15.

Uniklinik Köln, Institut für Diagnostische und Interventionelle Radiologie, Cologne, Germany.

Background: Ex vivo computed tomography (CT) studies of artificial blood thrombi showed that contrast enhancement (CE) is determined by fibrin-content, while unenhanced density is associated with red blood cells. Thus, the present study investigates patient outcome in association with combined thrombus density measures in native and contrast-enhanced CT (CECT) of acute ischemic stroke patients.

Methods: This retrospective study includes 137 patients with M1 occlusions treated by mechanical thrombectomy (MT) between 2010 and 2016. Read More

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http://dx.doi.org/10.1159/000495419DOI Listing
January 2019
1 Read

Adenosine Deaminase Two and Immunoglobulin M Accurately Differentiate Adult Sneddon's Syndrome of Unknown Cause.

Cerebrovasc Dis 2018 15;46(5-6):257-264. Epub 2019 Jan 15.

Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background: The association that exists between livedo reticularis (LR) and stroke is known as Sneddon's syndrome (SnS). The disorder is classified as primary SnS (PSnS), if the cause remains unknown and secondary SnS. The condition is rare and it occurs mainly sporadically. Read More

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http://dx.doi.org/10.1159/000495794DOI Listing
January 2019
3 Reads

Cholesterol Crystals in Embolic Debris are Associated with Postoperative Cerebral Embolism after Carotid Artery Stenting.

Cerebrovasc Dis 2018 2;46(5-6):242-248. Epub 2019 Jan 2.

Department of Neurosurgery, Stroke Center, Ise Red Cross Hospital, Ise City, Japan.

Object: We investigated possible associations among the presence of cholesterol crystals in embolic debris, the proportions of debris components, and postoperative cerebral embolism in patients undergoing carotid artery stenting (CAS).

Methods: Sixty-seven consecutive procedures were performed for internal carotid artery stenosis with CAS at our hospital between November 2015 and February 2018. Procedures for emergency CAS for stroke in evolution or crescendo transient ischemic attack were excluded (n = 12). Read More

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http://dx.doi.org/10.1159/000495795DOI Listing
January 2019
3 Reads

Baseline Characteristics and Readmissions after Cerebral Venous Sinus Thrombosis in a Nationally Representative Database.

Cerebrovasc Dis 2018 2;46(5-6):249-256. Epub 2019 Jan 2.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York,

Background: There are limited epidemiologic data on cerebral venous sinus thrombosis (CVST). We aim to summarize baseline characteristics and outcomes using a large nationally representative administrative database.

Methods: Using the 2013 Nationwide Readmissions Database, we used validated International Classification of Disease, Ninth Revision codes to identify baseline characteristics of patients admitted with CVST. Read More

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http://dx.doi.org/10.1159/000495420DOI Listing
January 2019
1 Read

Left-Sided Atrial Septal Pouch as a Risk Factor of Cryptogenic Stroke: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2018 5;46(5-6):223-229. Epub 2018 Dec 5.

HEART, Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.

Background: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach.

Methods: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control. Read More

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http://dx.doi.org/10.1159/000495573DOI Listing
December 2018
3 Reads

A Systematic Review and Meta-Analysis of Molecular Biomarkers Associated with Early Neurological Deterioration Following Acute Stroke.

Cerebrovasc Dis 2018 5;46(5-6):230-241. Epub 2018 Dec 5.

NIHR Newcastle Biomedical Research Centre and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United

Background: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END. Read More

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https://www.karger.com/Article/FullText/495572
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http://dx.doi.org/10.1159/000495572DOI Listing
December 2018
10 Reads

Cervical Artery Dissection in Patients of African Ancestry.

Cerebrovasc Dis 2018 5;46(5-6):218-222. Epub 2018 Dec 5.

Departments of Neurology, University of Virginia Health System, Charlottesville, Virginia,

Background And Purpose: The majority of published data in cervical artery dissection (CeAD), a common cause of stroke in young adults, derive from populations of European ancestry (EA), including a recent genome-wide study identifying an association with the rs9349379 polymorphism of the PHACTR1 gene. Little is known about CeAD in individuals of African ancestry (AA) despite robust epidemiological data showing increased risk of stroke at younger ages. We hypothesize that AA patients with CeAD have different epidemiology and clinical profiles compared to those of EA, and a different genetic architecture related to rs9349379 of the PHACTR1 gene. Read More

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http://dx.doi.org/10.1159/000494704DOI Listing
December 2018
3 Reads

The Management of Acute Ischemic Strokes and the Prevalence of Large Vessel Occlusion in Left Ventricular Assist Device.

Cerebrovasc Dis 2018 4;46(5-6):213-217. Epub 2018 Dec 4.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio,

Background: Ischemic and hemorrhagic strokes are frequent complications among those with left ventricular assist device (LVAD). Scarce data exist regarding the prevalence of acute large vessel occlusion (LVO) and treatment of acute ischemic stroke (AIS) in this setting.

Methods: We reviewed prospectively collected data of LVAD patient registry from a single, tertiary center from October 2004 to November 2016. Read More

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http://dx.doi.org/10.1159/000495080DOI Listing
December 2018
9 Reads

Challenge of Attaining Flow Arrest in Anterior Circulation Tandem Occlusions in Large Vessel Ischemic Stroke: Wedged SAVE Technique.

Cerebrovasc Dis 2018 12;46(5-6):211-212. Epub 2018 Nov 12.

Department of Neuroradiology, University Hospital of Aachen, Aachen, Germany.

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https://www.karger.com/Article/FullText/494703
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http://dx.doi.org/10.1159/000494703DOI Listing
November 2018
9 Reads

The Impact of Cerebral Atherosclerosis According to Location on Prognosis after Coronary Artery Bypass Grafting.

Cerebrovasc Dis 2018 8;46(5-6):200-209. Epub 2018 Nov 8.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of

Background: In the previous prospective observational study, we found that cerebral atherosclerosis is an independent predictor of acute stroke after coronary artery bypass grafting (CABG). However, it is unknown whether intracranial cerebral atherosclerosis (ICAS) is important as much as extracranial cerebral atherosclerosis (ECAS) in estimating the risk of post-CABG adverse events. Extending the previous study, we aimed to investigate the immediate and long-term prognostic value of the location of cerebral atherosclerosis in CABG patients. Read More

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https://www.karger.com/Article/FullText/494502
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http://dx.doi.org/10.1159/000494502DOI Listing
November 2018
18 Reads

Ten-Year Evaluation of the TOYOTA Prehospital Stroke Scale for Tissue Plasminogen Activator Intravenous Therapy in the Real World.

Cerebrovasc Dis 2018 1;46(3-4):186-194. Epub 2018 Nov 1.

Department of Neurology, TOYOTA Memorial Hospital, Toyota, Japan.

Background: Emergency medical services are an important part of acute stroke management. We devised a prehospital stroke scale, the TOYOTA prehospital stroke scale for tissue plasminogen activator (t-PA) intravenous therapy (TOPSPIN) for triaging patients with ischemic stroke and especial indications for intravenous t-PA therapy in December 2006; this scale comprises 5 items including consciousness, atrial fibrillation, language disorder, disturbance of the upper extremities, and disturbance of the lower extremities. The aim of this study was to analyze the results of 10 years of TOPSPIN implementation and to distinguish ischemic stroke from hemorrhagic stroke in the real world. Read More

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http://dx.doi.org/10.1159/000494364DOI Listing
November 2018
4 Reads

Safety of Endovascular Thrombectomy for Acute Ischaemic Stroke in Anticoagulated Patients Ineligible for Intravenous Thrombolysis.

Cerebrovasc Dis 2018 1;46(5-6):193-199. Epub 2018 Nov 1.

Department of Radiology, Neurointervention Service, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria,

Background/aim: Endovascular thrombectomy may be performed in anticoagulated patients taking vitamin-K antagonists (VKA) or direct-acting oral anticoagulants (DOAC) in whom the use of intravenous tissue plasminogen activator (tPA) is contraindicated. We aimed to investigate the efficacy and safety of mechanical thrombectomy specifically in anticoagulated patients ineligible for thrombolysis.

Methods: We performed a retrospective analysis of a prospectively collected database of consecutive ischaemic stroke patients undergoing mechanical thrombectomy from January 2008 to June 2017. Read More

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http://dx.doi.org/10.1159/000493801DOI Listing
November 2018
10 Reads

Transcranial Magnetic Stimulation as an Intervention Tool to Recover from Language, Swallowing and Attentional Deficits after Stroke: A Systematic Review.

Cerebrovasc Dis 2018 19;46(3-4):178-185. Epub 2018 Oct 19.

Coimbra Institute for Biomedical Imaging and Translational Research/Institute of Nuclear Sciences Applied to Health (CIBIT/ICNAS), University of Coimbra, Coimbra,

Background: Following a stroke event, patients often are severely affected by disabilities that hinder their quality-of-life. There are currently several rehabilitative options and strategies, and it is crucial to find the most effective interventions. The applicability of transcranial magnetic stimulation (TMS) to the recovery of nonmotor functions such as communication skills, swallowing ability and spatial attention after stroke remains important clinical questions. Read More

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http://dx.doi.org/10.1159/000494213DOI Listing
October 2018
5 Reads

Endovascular Clot Retrieval by Hub-and-Spoke Service Delivery is Feasible Compared with Direct-to-Mothership.

Cerebrovasc Dis 2018 9;46(3-4):172-177. Epub 2018 Oct 9.

Department of Radiology, Neurointervention Service, Royal Melbourne Hospital, Melbourne, Victoria,

Background: Endovascular clot retrieval (ECR) improves outcomes for acute ischaemic stroke with large artery occlusion. However, the provision of ECR requires resource-intensive comprehensive stroke centres (CSC), which are impractical to establish in regional hospitals. An alternative is a "hub-and-spoke" model, whereby ischaemic strokes are triaged at the regional primary centres and where eligible, transferred to a CSC. Read More

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https://www.karger.com/Article/FullText/490421
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http://dx.doi.org/10.1159/000490421DOI Listing
October 2018
4 Reads

ACTA2 Cerebral Arteriopathy: Not Just a Puff of Smoke.

Cerebrovasc Dis 2018 9;46(3-4):161-171. Epub 2018 Oct 9.

Carilion Clinic, Section of Neurosurgery, Roanoke, Virginia, USA.

Background: Missense mutations in the gene that codes for smooth muscle actin, ACTA2, cause diffuse smooth muscle dysfunction and a distinct cerebral arteriopathy collectively known as multisystemic smooth muscle dysfunction syndrome (MSMDS). Until recently, ACTA2 cerebral arteriopathy was considered to be a variant of moyamoya disease. However, recent basic science and clinical data have demonstrated that the cerebral arteriopathy caused by mutant ACTA2 exhibits genetic loci, histopathology, neurological sequelae, and radiographic findings unique from moyamoya disease. Read More

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https://www.karger.com/Article/FullText/493863
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http://dx.doi.org/10.1159/000493863DOI Listing
October 2018
11 Reads

Predicting Dysphagia with National Institute of Health Stroke Scale: Distinction between Infra- and Supratentorial Region is Essential.

Cerebrovasc Dis 2018 25;46(3-4):152-160. Epub 2018 Sep 25.

Background: For the early detection of post-stroke dysphagia (PSD), valid screening parameters are crucial as part of a step-wise diagnostic procedure. This study examines the role of the National Institute of Health Stroke Scale (NIH-SS) as a potential low-threshold screening parameter.

Methods: During a ten-year period, 687 newly admitted patients at University Hospital Muenster were included in a retrospective analysis, if they had ischemic or haemorrhagic stroke confirmed by neuroimaging and had received NIH-SS scoring and endoscopic swallowing evaluation upon admission. Read More

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https://www.karger.com/Article/FullText/493371
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http://dx.doi.org/10.1159/000493371DOI Listing
September 2018
11 Reads

Insulin Resistance Index from Oral Glucose Tolerance Test Predicts Ischemic Stroke Outcomes in Non-Diabetic Patients with Different Estimated Glomerular Filtration Rate Strata.

Cerebrovasc Dis 2018 20;46(3-4):142-151. Epub 2018 Sep 20.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Insulin resistance is associated with cardiovascular morbidity and mortality in the general population. However, the relationship between insulin resistance and health outcomes is controversial in patients with impaired renal function. Our study aimed to investigate the association between insulin resistance and prognosis in a cohort of non-diabetic stroke patients with different estimated glomerular filtration rate (eGFR) strata. Read More

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http://dx.doi.org/10.1159/000492125DOI Listing
September 2018
4 Reads
3.754 Impact Factor

Mechanical Thrombectomy in Acute Stroke Due to Carotid Occlusion: A Series of 153 Consecutive Patients.

Cerebrovasc Dis 2018 13;46(3-4):132-141. Epub 2018 Sep 13.

Section of Interventional Neuroradiology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.

Background: Strokes due to carotid artery occlusion (CAO) are associated with bad clinical prognosis and poor response to intravenous thrombolysis. Several studies in the past have shown the benefits of mechanical thrombectomy (MT) and compared bridging therapy (BT) and primary MT (PMT) in large vessel occlusions, but only a few studies have focused on the specific population of CAO and their response to endovascular treatment.

Methods: Retrospective review of patients treated at our center between January 2010 and June 2017 that (1) presented with acute ischemic stroke caused by CAO in the first 4. Read More

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https://www.karger.com/Article/FullText/492866
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http://dx.doi.org/10.1159/000492866DOI Listing
September 2018
10 Reads

Patterns and Outcomes of the Top of the Basilar Artery Syndrome: The Role of the Posterior Communicating Artery.

Cerebrovasc Dis 2018 10;46(3-4):108-117. Epub 2018 Sep 10.

Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of

Background: Clinical syndromes secondary to infarcts in the distal basilar artery (BA) area have been described as "top of the basilar" (TOB) syndrome. However, in the era of advanced imaging technology, it has been realized that the clinical and imaging features are quite diverse in patients with distal BA occlusion. The aim of the present study was to investigate the patterns and clinical outcomes of TOB assessed with modern images and categorize TOBs accordingly. Read More

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http://dx.doi.org/10.1159/000492059DOI Listing
September 2018
2 Reads

Hypercoagulation on Thromboelastography Predicts Early Neurological Deterioration in Patients with Acute Ischemic Stroke.

Cerebrovasc Dis 2018 10;46(3-4):125-131. Epub 2018 Sep 10.

Department of Neurology, Dongguan People's Hospital, Dongguan, China.

Background: Thromboelastography (TEG) provides an integrated measurement of blood coagulation function and has been reported to be a useful tool for predicting clinical outcomes in patients with cardiovascular diseases. We aimed to investigate the application of TEG on admission for predicting early neurological deterioration (END) in patients with acute ischemic stroke and its potential correlation with the evolution of ischemic lesions.

Methods: Among patients consecutively admitted between January 1, 2016, and September 31, 2017, those presenting with mild and moderate acute ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score ≤14) within 24 h of stroke onset were identified and included in this study. Read More

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http://dx.doi.org/10.1159/000492729DOI Listing
September 2018
15 Reads

Impact of Dysphagia Assessment and Management on Risk of Stroke-Associated Pneumonia: A Systematic Review.

Cerebrovasc Dis 2018 10;46(3-4):99-107. Epub 2018 Sep 10.

Greater Manchester Comprehensive Stroke Centre, Manchester Academic Health Science Centre, Salford Royal Foundation Trust, Salford, United Kingdom.

Background: Patients with dysphagia are at an increased risk of stroke-associated pneumonia. There is wide variation in the way patients are screened and assessed during the acute phase. The aim of this review was to identify the methods of assessment and management in acute stroke that influence the risk of stroke-associated pneumonia. Read More

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https://www.karger.com/Article/FullText/492730
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http://dx.doi.org/10.1159/000492730DOI Listing
September 2018
7 Reads

Early Achievement of Blood Pressure Lowering and Hematoma Growth in Acute Intracerebral Hemorrhage: Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement-Intracerebral Hemorrhage Study.

Cerebrovasc Dis 2018 10;46(3-4):118-124. Epub 2018 Sep 10.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Background: Previous studies have revealed that hematoma growth mainly occurs during the first 6 h after the onset of spontaneous intracerebral hemorrhage (ICH). Early lowering of blood pressure (BP) may be beneficial for preventing hematoma growth. However, relationships between timing of BP lowering and hematoma growth in ICH remain unclear. Read More

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http://dx.doi.org/10.1159/000492728DOI Listing
September 2018
2 Reads

Onset to Reperfusion Time Was Not Important in Mechanical Thrombectomy for Elderly Patients: A Retrospective Multicenter Study in Tama Area, Tokyo.

Cerebrovasc Dis 2018 6;46(1-2):89-96. Epub 2018 Sep 6.

Department of Stroke and Cerebrovascular Medicine, Kyorin University, Mitaka, Japan.

Background: Mechanical thrombectomy (MT) has become the standard of care for acute ischemic stroke with large vessel occlusion; however, evidence remains insufficient for MT for elderly patients, especially with respect to factors affecting their outcomes.

Methods: This study was a retrospective analysis of a multicenter registry of MT, called Tama Registry of Acute Endovascular Thrombectomy. Patients were divided by their age into 2 groups: Nonelderly (NE; < 80) and elderly (E; ≥80). Read More

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https://www.karger.com/Article/FullText/492867
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http://dx.doi.org/10.1159/000492867DOI Listing
September 2018
8 Reads

Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies.

Cerebrovasc Dis 2018 5;46(1-2):82-88. Epub 2018 Sep 5.

Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.

Background And Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke.

Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. Read More

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http://dx.doi.org/10.1159/000492625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214602PMC
September 2018
5 Reads

Peak Troponin I Levels Are Associated with Functional Outcome in Intracerebral Hemorrhage.

Cerebrovasc Dis 2018 23;46(1-2):72-81. Epub 2018 Aug 23.

Department of Neurology, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany.

Background: Troponin I is a widely used and reliable marker of myocardial damage and its levels are routinely measured in acute stroke care. So far, the influence of troponin I elevations during hospital stay on functional outcome in patients with atraumatic intracerebral hemorrhage (ICH) is unknown.

Methods: Observational single-center study including conservatively treated ICH patients over a 9-year period. Read More

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http://dx.doi.org/10.1159/000492395DOI Listing
August 2018
13 Reads

Telestroke in Catalonia: Increasing Thrombolysis Rate and Avoiding Interhospital Transfers.

Cerebrovasc Dis 2018 22;46(1-2):66-71. Epub 2018 Aug 22.

Hospital Germans Trias i Pujol, Barcelona, Spain.

Objectives: The study aimed to evaluate the impact of a telestroke network on acute stroke care in Catalonia, by measuring thrombolysis rates, access to endovascular treatment, and clinical outcome of telestroke patients in a population-based study.

Methods: Telestroke network was implemented on March 2013 and consists of 12 community hospitals and 1 expert stroke neurologist 24 h/7 day, covering a population of 1.3 million inhabitants. Read More

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http://dx.doi.org/10.1159/000492124DOI Listing
August 2018
15 Reads

Delayed Intravenous Thrombolysis in Patients with Minor Stroke.

Cerebrovasc Dis 2018 9;46(1-2):52-58. Epub 2018 Aug 9.

Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: The actions and responses of the hospital personnel during acute stroke care in the emergency department (ED) may differ according to the severity of a patient's stroke symptoms. We investigated whether the time from arrival at ED to various care steps differed between patients with minor and non-minor stroke who were treated with intravenous tissue plasminogen activator (IV tPA).

Methods: We included consecutive patients who received IV tPA during a 1. Read More

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http://dx.doi.org/10.1159/000492123DOI Listing
August 2018
18 Reads
3.754 Impact Factor

Order of Treatment Matters in Ischemic Stroke: Mechanical Thrombectomy First, Then Carotid Artery Stenting for Tandem Lesions of the Anterior Circulation.

Cerebrovasc Dis 2018 9;46(1-2):59-65. Epub 2018 Aug 9.

Department of Neuroradiology, University Hospital of Aachen, Aachen, Germany.

Background: One endovascular treatment option of acute ischemic stroke due to tandem occlusion (TO) comprises intracranial thrombectomy and acute extracranial carotid artery stenting (CAS). In this setting, the order of treatment may impact the clinical outcome in this stroke subtype.

Methods: Retrospective analysis was performed on data prospectively collected in 4 international stroke centers between 2013 and 2017. Read More

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http://dx.doi.org/10.1159/000492158DOI Listing
August 2018
3 Reads

Cancer-Associated Hypercoagulation Increases the Risk of Early Recurrent Stroke in Patients with Active Cancer.

Cerebrovasc Dis 2018 31;46(1-2):46-51. Epub 2018 Jul 31.

Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: This study assessed the incidence and predictors of short-term stroke recurrence in ischemic stroke patients with active cancer, and elucidated whether cancer-associated hypercoagulation is related to early recurrent stroke.

Methods: We retrospectively enrolled acute ischemic stroke patients with active cancer admitted to our hospital between 2006 and 2017. Active cancer was defined as diagnosis or treatment for any cancer within 12 months before stroke onset, known recurrent cancer or metastatic disease. Read More

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http://dx.doi.org/10.1159/000491436DOI Listing
July 2018
2 Reads

Time to Reset the Definition of Successful Revascularization in Endovascular Treatment of Acute Ischemic Stroke.

Cerebrovasc Dis 2018 31;46(1-2):40-45. Epub 2018 Jul 31.

Department of Neurology, Vila Nova de Gaia, Portugal.

Background: A 2013 consensus statement recommended the use of the modified Treatment In Cerebral Ischemia (mTICI) scale to evaluate angiographic revascularization after endovascular treatment (EVT) of acute ischemic stroke due to its higher inter-rater agreement and capacity of clinical outcome prediction. The current definition of successful revascularization includes the achievement of grades mTICI 2b or 3. However, mTICI 2b grade encompasses a large heterogeneity of revascularization states, and prior studies suggested that the magnitude of benefit derived from mTICI 2b and mTICI 3 does not seem to be equivalent. Read More

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http://dx.doi.org/10.1159/000491553DOI Listing
July 2018
5 Reads

Natural History of Cervical Artery Fibromuscular Dysplasia and Associated Neurovascular Events.

Cerebrovasc Dis 2018 31;46(1-2):33-39. Epub 2018 Jul 31.

Background And Purpose: Fibromuscular dysplasia (FMD) is a non-atherosclerotic arteriopathy most often affecting the carotid and renal arteries. In the United States Registry for FMD, 41.7% of patients experienced an aneurysm and/or dissection by the time of entry into the Registry. Read More

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http://dx.doi.org/10.1159/000491437DOI Listing
July 2018
3 Reads

Trendelenburg Positioning in Large Vessel Ischaemic Stroke: A Pre-Post Observational Study Using Propensity Score Matching.

Cerebrovasc Dis 2018 27;46(1-2):24-32. Epub 2018 Jul 27.

Université de Bordeaux, Bordeaux, France.

Background: Along with pharmacological and mechanical recanalization, improving cerebral perfusion through the recruitment of collateral vessels during the acute phase of ischaemic stroke (IS) is a clinical challenge. Our objective was to assess the effectiveness and safety of Trendelenburg positioning (TP), a procedure intended to increase cerebral blood flow, on the outcome of IS.

Methods: Two cohorts of patients with an acute supratentorial IS related to a large artery occlusion were compared. Read More

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http://dx.doi.org/10.1159/000490423DOI Listing
July 2018
1 Read

Is Perfusion MRI without Deconvolution Reliable for Mismatch Detection in Acute Stroke? Validation with 15O-Positron Emission Tomography.

Cerebrovasc Dis 2018 13;46(1-2):16-23. Epub 2018 Jul 13.

Max-Planck-Institute for Neurological Research, Cologne, Germany.

Background: In acute stroke, the magnetic resonance (MR) imaging-based mismatch concept is used to select patients with tissue at risk of infarction for reperfusion therapies. There is however a controversy if non-deconvolved or deconvolved perfusion weighted (PW) parameter maps perform better in tissue at risk prediction and which parameters and thresholds should be used to guide treatment decisions.

Methods: In a group of 22 acute stroke patients with consecutive MR and quantitative positron emission tomography (PET) imaging, non-deconvolved parameters were validated with the gold standard for penumbral-flow (PF) detection 15O-water PET. Read More

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http://dx.doi.org/10.1159/000490424DOI Listing
July 2018
14 Reads

The Impact of Pregnancy on Hemorrhagic Stroke in Young Women.

Cerebrovasc Dis 2018 6;46(1-2):10-15. Epub 2018 Jul 6.

Department of Neurology, New York, New York, USA.

Background: Pregnancy is a sex-specific risk factor for causing hemorrhagic stroke (HS) in young adults. Unique physiological characteristics during pregnancy may alter the relative risk for HS in pregnant/postpartum (PP) women compared to HS in other young women. We compared patient characteristics and HS subtypes between young non-pregnant and PP women. Read More

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http://dx.doi.org/10.1159/000490803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158089PMC
July 2018
20 Reads