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    3006 results match your criteria Cerebrovascular Diseases[Journal]

    1 OF 61

    Natural History of Vertebrobasilar Dolichoectatic and Fusiform Aneurysms: A Systematic Review and Meta-Analysis.
    Cerebrovasc Dis 2018 Feb 13;45(1-2):68-77. Epub 2018 Feb 13.
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
    Background And Purpose: Vertebrobasilar non-saccular and dolichoectatic aneurysms (VBDA) are a rare type of aneurysm and are generally associated with poor prognosis. In order to better characterize the natural history of VBDAs, we performed a systematic review and meta-analysis of the literature to determine rates of mortality, growth, rupture, ischemia, and intraparenchymal hemorrhage.

    Materials And Methods: We searched the literature for longitudinal natural history studies of VBDA patients reporting clinical and imaging outcomes. Read More

    Sensitive Detection of Atrial Fibrillation in Acute Stroke Patients by Short-Term Bedside Electrocardiography Monitoring Software Analysis.
    Cerebrovasc Dis 2018 Jan 17;45(1-2):54-60. Epub 2018 Jan 17.
    Department of Neurology, University Hospital of Muenster, Muenster, Germany.
    Background: Atrial fibrillation (AF) is an important cause of stroke. Continuous electrocardiography (ECG) monitoring with software-based analysis algorithms has been suggested to enhance the AF detection rate. We investigated the ability of stroke risk analysis (SRA) in the detection of AF in acute stroke patients. Read More

    When to Screen Ischaemic Stroke Patients for Cancer.
    Cerebrovasc Dis 2018 Jan 9;45(1-2):42-47. Epub 2018 Jan 9.
    Department of Clinical Medicine, University of Bergen, Bergen, Norway.
    Background And Purpose: Ischemic stroke can be the first manifestation of cancer and it is therefore important to ascertain which stroke patients should be considered for cancer-diagnostic investigations. We aimed to determine the frequency of active cancer in patients with acute ischemic stroke and to compare clinical findings in stroke patients with active cancer to ischemic stroke patients with no history of cancer. Finally, we aimed to develop a predictive and feasible score for clinical use to uncover underlying malignancy. Read More

    Black Hole Sign Predicts Poor Outcome in Patients with Intracerebral Hemorrhage.
    Cerebrovasc Dis 2018 Jan 10;45(1-2):48-53. Epub 2018 Jan 10.
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Background: In spontaneous intracerebral hemorrhage (ICH), black hole sign has been proposed as a promising imaging marker that predicts hematoma expansion in patients with ICH. The aim of our study was to investigate whether admission CT black hole sign predicts hematoma growth in patients with ICH.

    Methods: From July 2011 till February 2016, patients with spontaneous ICH who underwent baseline CT scan within 6 h of symptoms onset and follow-up CT scan were recruited into the study. Read More

    Computed Tomography Perfusion Derived Blood-Brain Barrier Permeability Does Not Yet Improve Prediction of Hemorrhagic Transformation.
    Cerebrovasc Dis 2018 Jan 8;45(1-2):26-32. Epub 2018 Jan 8.
    Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
    Introduction: Hemorrhagic transformation (HT) in acute ischemic stroke can occur as a result of reperfusion treatment. While withholding treatment may be warranted in patients with increased risk of HT, prediction of HT remains difficult. Nonlinear regression analysis can be used to estimate blood-brain barrier permeability (BBBP). Read More

    Predictors for Mortality after Mechanical Thrombectomy of Acute Basilar Artery Occlusion.
    Cerebrovasc Dis 2018 Jan 30;45(1-2):61-67. Epub 2018 Jan 30.
    Department of Neurology, Stroke Center, Foch Hospital, Suresnes, France.
    Background: Modern endovascular thrombectomy (MET), using stent retrievers or large-bore distal aspiration catheters in stroke patients with acute basilar artery occlusion (BAO), is routinely performed to date. However, more than 35% of BAO patients treated with MET die within 90 days despite high recanalization rates. The purpose of this study is to investigate the parameters associated with 90-day mortality in patients with BAO after MET. Read More

    Primary Prevention of Stroke in Chronic Kidney Disease Patients: A Scientific Update.
    Cerebrovasc Dis 2018 Jan 9;45(1-2):33-41. Epub 2018 Jan 9.
    Department of Nephrology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Background: Although chronic kidney disease (CKD) is an independent risk factor for stroke, official recommendations for the primary prevention of stroke in CKD are generally lacking.

    Summary: We searched PubMed and ISI Web of Science for randomised controlled trials, observational studies, reviews, meta-analyses and guidelines referring to measures of stroke prevention or to the treatment of stroke-associated risk factors (cardiovascular disease in general and atrial fibrillation (AF), arterial hypertension or carotid artery disease in particular) among the CKD population. The use of oral anticoagulation in AF appears safe in non-end stage CKD, but it should be individualized and preferably based on thromboembolic and bleeding stratification algorithms. Read More

    Carotid Artery Stenosis Contralateral to Acute Tandem Occlusion: An Independent Predictor of Poor Clinical Outcome after Mechanical Thrombectomy with Concomitant Carotid Artery Stenting.
    Cerebrovasc Dis 2017 Nov 24;45(1-2):10-17. Epub 2017 Nov 24.
    Department of Neuroradiology, University Hospital of Aachen, Aachen, Germany.
    Background And Purpose: Cerebral ischemic strokes due to extra-/intracranial tandem occlusions (TO) of the anterior circulation are responsible for causing mechanical thrombectomy (MT). The impact of concomitant contralateral carotid stenosis (CCS) upon outcome remains unclear in this stroke subtype.

    Methods: Retrospective analysis of prospectively collected data of 4 international stroke centers between 2011 and 2017. Read More

    High Systolic Blood Pressure after Successful Endovascular Treatment Affects Early Functional Outcome in Acute Ischemic Stroke.
    Cerebrovasc Dis 2017 Nov 24;45(1-2):18-25. Epub 2017 Nov 24.
    Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
    Background: Endovascular treatment (EVT) has been shown to significantly improve functional outcome in patients with acute large cerebral vessel occlusions. To date, no evidence-based recommendations on blood pressure management after successful EVT exist. Previous studies showed an association between high pre-EVT systolic blood pressure (SBP) and functional outcome, but do not answer the question on how to manage blood pressure after successful recanalization. Read More

    Acute Kidney Injury Following Acute Ischemic Stroke and Intracerebral Hemorrhage: A Meta-Analysis of Prevalence Rate and Mortality Risk.
    Cerebrovasc Dis 2017 Nov 24;45(1-2):1-9. Epub 2017 Nov 24.
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Background: The epidemiology of acute renal dysfunction after stroke is routinely overlooked following stroke events. Our aim in this meta-analysis is to report the prevalence of acute kidney injury (AKI) following acute stroke and its impact on mortality.

    Methods: A systematic literature search was performed on PubMed, EMBASE and Google Scholar for observational studies examining the prevalence and mortality risk of stroke patients with AKI as a complication. Read More

    Ischemic Stroke: Histological Thrombus Composition and Pre-Interventional CT Attenuation Are Associated with Intervention Time and Rate of Secondary Embolism.
    Cerebrovasc Dis 2017 Oct 31;44(5-6):344-350. Epub 2017 Oct 31.
    Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
    Background And Purpose: The introduction of stent retrievers has made the complete extraction and histological analysis of human thrombi possible. A number of large randomized trials have proven the efficacy of thrombectomy for ischemic stroke; however, thrombus composition could have an impact on the efficacy and risk of the intervention. We therefore investigated the impact of histologic thrombus features on interventional outcome and procedure-related embolisms. Read More

    Prehospital Computed Tomography Angiography in Acute Stroke Management.
    Cerebrovasc Dis 2017 Oct 31;44(5-6):338-343. Epub 2017 Oct 31.
    Department of Neurology, Saarland University Medical Center, Homburg, Germany.
    Background: An ambulance equipped with a computed tomography (CT) scanner, a point-of-care laboratory, and telemedicine capabilities (mobile stroke unit [MSU]) has been shown to enable the delivery of thrombolysis to stroke patients directly at the emergency site, thereby significantly decreasing time to treatment. However, work-up in an MSU that includes CT angiography (CTA) may also potentially facilitate triage of patients directly to the appropriate target hospital and specialized treatment, according to their individual vascular pathology.

    Methods: Our institution manages a program investigating the prehospital management of patients with suspicion of acute stroke. Read More

    Influence of Renal Function on Treatment Results after Stroke Thrombectomy.
    Cerebrovasc Dis 2017 Oct 31;44(5-6):351-358. Epub 2017 Oct 31.
    Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
    Background: Renal dysfunction (RD) may be associated with poor outcome in ischemic stroke patients treated with mechanical thrombectomy (MT), but data concerning this important and emerging comorbidity do not exist so far. Here, we investigated the influence of RD on postprocedural intracerebral hemorrhage (ICH), clinical outcome, and mortality in a large prospectively collected cohort of acute ischemic stroke patients treated with MT.

    Methods: Consecutive patients with anterior-circulation stroke treated with MT between October 2010 and January 2016 were included. Read More

    Early Cognitive Impairment after Intracerebral Hemorrhage in the INTERACT1 Study.
    Cerebrovasc Dis 2017 Oct 26;44(5-6):320-324. Epub 2017 Oct 26.
    The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
    Background: Data on cognitive impairment after acute intracerebral hemorrhage (ICH) are limited. This study is aimed at determining the frequency and predictors of cognitive impairment among participants of the pilot phase, Intensive Blood Pressure (BP) Reduction in Acute Cerebral Hemorrhage Trial (INTERACT1).

    Methods: INTERACT1 was an open randomized trial of early intensive (target systolic BP <140 mm Hg) compared with contemporaneous guideline-recommended BP lowering in 404 patients with elevated systolic BP (150-220 mm Hg) within 6 h of ICH onset. Read More

    Serum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled Diabetes.
    Cerebrovasc Dis 2017 Oct 26;44(5-6):325-329. Epub 2017 Oct 26.
    Human Health Science, Graduate School of Medicine and Faculty of Medicine Kyoto University, Kyoto, Japan.
    Background: Serum 1,5-anhydroglucitol (1,5-AG) levels are a measure that provides information on daily glycemic variations. We evaluated whether 1,5-AG could be a possible marker of acute ischemic stroke (AIS) or transient ischemic attacks (TIA) in patients with diabetes mellitus (DM).

    Methods: We retrospectively reviewed electronic medical records of 5,294 AIS/TIA patients. Read More

    Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study.
    Cerebrovasc Dis 2017 Oct 26;44(5-6):330-337. Epub 2017 Oct 26.
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience (MHeNs), Alzheimer Center Limburg, Maastricht, the Netherlands.
    Background: Poststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA. Read More

    Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study.
    Cerebrovasc Dis 2017 Oct 3;44(5-6):304-312. Epub 2017 Oct 3.
    Paris VI University, Pierre et Marie Curie, Paris, France.
    Background: Brain arteriovenous malformations (BAVMs) are a leading cause of intracranial hemorrhage in young adults. This study aimed to identify individual predictive factors of early rebleeding after BAVM rupture and determine its impact on prognosis.

    Methods: Early rebleeding was defined as a spontaneous intracranial hemorrhage within 30 days of BAVM rupture in patients with nonobliterated BAVMs. Read More

    Cerebral Cavernous Malformations: Patient-Reported Outcome Validates Conservative Management.
    Cerebrovasc Dis 2017 Oct 3;44(5-6):313-319. Epub 2017 Oct 3.
    Department of Surgery, Division of Neurosurgery, Hospital Universitário Clementino Fraga Filho and Program of Post-Graduation in Surgical Sciences of the Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Cerebral cavernous malformations (CCM) are clusters of dilated sinusoidal channels lined by a single layer of endothelium. In contradistinction to arteriovenous malformations, these lesions do not have smooth muscle or elastin in their lining and they are angiographically occult, and the MRI is the most sensitive test for CCM detection. CCM are one of the most prevalent vascular malformations of the central nervous system, affecting about 0. Read More

    Ischemic Stroke Patients Demonstrate Increased Carotid Plaque Microvasculature Compared to (Ocular) Transient Ischemic Attack Patients.
    Cerebrovasc Dis 2017 Sep 26;44(5-6):297-303. Epub 2017 Sep 26.
    Background: Patients with a recent ischemic stroke have a higher risk of recurrent stroke compared to (ocular) transient ischemic attack (TIA) patients. Plaque microvasculature is considered as a feature of plaque vulnerability and can be quantified with carotid dynamic contrast-enhanced MRI (DCE-MRI). The purpose of this cross-sectional study was to explore the association between plaque microvasculature and the type of recent cerebrovascular events in symptomatic patients with mild-to-moderate carotid stenosis. Read More

    Cerebral Infarct Topography and Early Outcome after Surgery for Symptomatic Carotid Stenosis: A Multicentre Study.
    Cerebrovasc Dis 2017 Sep 15;44(5-6):291-296. Epub 2017 Sep 15.
    Department of Cardiovascular and Thoracic Surgery, Dijon University Hospital, Dijon, France.
    Introduction: Although carotid stenosis can cause both territorial and border-zone (BZ) cerebral infarcts (CI), the influence of CI topography on postoperative complications after surgery remains unclear. We compared early outcomes after endarterectomy on the basis of CI location: territorial (T group) or BZ group.

    Material And Methods: During the period between 2009 and 2013, ischaemic stroke patients who had undergone surgery for symptomatic carotid stenosis were identified from prospective databases from 3 French centres. Read More

    Early Screening Parameters for Dysphagia in Acute Ischemic Stroke.
    Cerebrovasc Dis 2017 Sep 14;44(5-6):285-290. Epub 2017 Sep 14.
    Department of Neurology, HELIOS HSK Wiesbaden, Wiesbaden, Germany.
    Background: Dysphagia is a frequent symptom in patients with acute stroke. It is associated with malnutrition, aspiration and mortality. The identification of early screening parameters for dysphagia promptly leading to a professional swallowing examination is therefore of utmost importance. Read More

    Selection Paradigms for Large Vessel Occlusion Acute Ischemic Stroke Endovascular Therapy.
    Cerebrovasc Dis 2017 Sep 7;44(5-6):277-284. Epub 2017 Sep 7.
    Departments of Neurology, Radiology and Neurosurgery Grady Memorial Hospital and Emory University School of Medicine, Atlanta, GA, USA.
    Background: Optimal patient selection methods for thrombectomy in large vessel occlusion stroke (LVOS) are yet to be established. We sought to evaluate the ability of different selection paradigms to predict favorable outcomes.

    Methods: Review of a prospectively collected database of endovascular patients with anterior circulation LVOS, adequate CT perfusion (CTP), National Institutes of Health Stroke Scale (NIHSS) ≥10 from September 2010 to March 2016. Read More

    Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke.
    Cerebrovasc Dis 2017 Sep 5;44(5-6):266-276. Epub 2017 Sep 5.
    Prediction measures of recovery and outcome after stroke perform with only modest levels of accuracy if based only on clinical data. Prediction scores can be improved by including morphologic imaging data, where size, location, and development of the ischemic lesion is best documented by magnetic resonance imaging. In addition to the primary lesion, the involvement of fiber tracts contributes to prognosis, and consequently the use of diffusion tensor imaging (DTI) to assess primary and secondary pathways improves the prediction of outcome and of therapeutic effects. Read More

    N-Terminal Prosomatostatin and Risk of Vascular Dementia.
    Cerebrovasc Dis 2017 Aug 31;44(5-6):259-265. Epub 2017 Aug 31.
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmö, Sweden.
    Background: Increased somatostatin plasma concentration has been found in patients with vascular dementia. However, it is unknown whether or not somatostatin levels may predict dementia development in the general population. To this end, we sought to assess the association of circulating N-terminal prosomatostatin (NT-proSST) with incident dementia among community-dwelling older adults. Read More

    Clinical Effectiveness and Safety Outcomes of Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke in China.
    Cerebrovasc Dis 2017 Aug 26;44(5-6):248-258. Epub 2017 Aug 26.
    Backgrounds And Purpose: This study was aimed at investigating the outcomes and predictors for the poor functional outcome after endovascular treatment (EVT) in a large, mostly Asian population.

    Methods: Between January 2014 and June 2016, acute stroke patients with anterior circulation occlusion and EVT were retrospectively enrolled from 21 stroke centers in China. The main outcomes were modified Rankin Scale (0-2 as functional independence, 3-6 as poor) at 90 days, symptomatic intracranial hemorrhage (sICH) at 72 h, and death at 90 days. Read More

    Multimorbidities Are Associated to Lower Survival in Ischaemic Stroke: Results from a Brazilian Stroke Cohort (EMMA Study).
    Cerebrovasc Dis 2017 19;44(3-4):232-239. Epub 2017 Aug 19.
    Hospital Universitário, São Paulo, Brazil.
    Background: Stroke prognosis is related to the multimorbidity profile. Moreover, performing an individual evaluation of most common cerebrovascular risk factors (CVRF) not always identifies patients with poor prognosis. Thus, we decided to evaluate multimorbidity profile, focusing on the Charlson Comorbidity Index (CCI) validated by Goldstein for ischaemic stroke (IS) patients, a score that measures a burden of comorbidities and its related mortality in the long-term survival of the EMMA Study (Study of Stroke Mortality and Morbidity). Read More

    Magnetic Resonance Imaging Susceptibility-Weighted Imaging Lesion and Contrast Enhancement May Represent Infectious Intracranial Aneurysm in Infective Endocarditis.
    Cerebrovasc Dis 2017 19;44(3-4):210-216. Epub 2017 Aug 19.
    Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
    Background: Infectious intracranial aneurysm (IIA) can complicate infective endocarditis (IE). We aimed to describe the magnetic resonance imaging (MRI) characteristics of IIA.

    Methods: We reviewed IIAs among 116 consecutive patients with active IE by conducting a neurological evaluation at a single tertiary referral center from January 2015 to July 2016. Read More

    Mechanical Thrombectomy for Acute Basilar Artery Occlusion in Early Therapeutic Time Window.
    Cerebrovasc Dis 2017 19;44(3-4):217-224. Epub 2017 Aug 19.
    Department of Neurosurgery, Baba Memorial Hospital, Sakai, Japan.
    Background: The natural history of basilar artery occlusion (BAO) is devastating, with morbidity rates increasing up to 80%. However, the efficacy of recanalization therapy for BAO has not been established as yet.

    Objective: We analyzed consecutive cases of BAO treated with mechanical thrombectomy (MT) to evaluate its safety and efficacy and to determine factors associated with the prognosis. Read More

    Telehealth Stroke Dysphagia Evaluation Is Safe and Effective.
    Cerebrovasc Dis 2017 19;44(3-4):225-231. Epub 2017 Aug 19.
    Regional Rehabilitation Services, Portland, OR, USA.
    Background: Rapid evaluation of dysphagia poststroke significantly lowers rates of aspiration pneumonia. Logistical barriers often significantly delay in-person dysphagia evaluation by speech language pathologists (SLPs) in remote and rural hospitals. Clinical swallow evaluations delivered via telehealth have been validated in a number of clinical contexts, yet no one has specifically validated a teleswallow evaluation for in-hospital post-stroke dysphagia assessment. Read More

    The Impact of Discrepancy between Measured versus Stated Weight on Hemorrhagic Transformation and Clinical Outcomes after Intravenous Alteplase Thrombolysis.
    Cerebrovasc Dis 2017 Aug 26;44(5-6):241-247. Epub 2017 Aug 26.
    Department of Neurology, Gachon University Gil Medical Center, Incheon, South Korea.
    Background: An accurate measurement of patient weight is important in determining the dosage for intravenous alteplase thrombolysis. In most emergency rooms, however, weight is not measured. We investigated the difference between stated and measured weight and its effect on hemorrhagic transformation and clinical outcomes. Read More

    Reliability, Reproducibility and Prognostic Accuracy of the Alberta Stroke Program Early CT Score on CT Perfusion and Non-Contrast CT in Hyperacute Stroke.
    Cerebrovasc Dis 2017 16;44(3-4):195-202. Epub 2017 Aug 16.
    Melbourne Brain Centre, Royal Melbourne Hospital and Department of Medicine, University of Melbourne, Parkville, VIC, Australia.
    Background: Alberta Stroke Program Early CT Score (ASPECTS) assesses early ischemic change on non-contrast CT (NCCT). We hypothesised that assessing ASPECTS regions on CT Perfusion (CTP) rather than NCCT would improve inter-rater agreement and prognostic accuracy, particularly in patients presenting early after stroke onset.

    Methods: Ischemic stroke patients treated with intravenous alteplase from 2009 to 2014 at our institution were included in this study. Read More

    The Prevalence of and Factors Related to Vascular Hyperintensity on T1-Weighted Imaging in Acute Ischemic Stroke.
    Cerebrovasc Dis 2017 16;44(3-4):203-209. Epub 2017 Aug 16.
    Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
    Background: Thrombus visualization in patients with acute ischemic stroke has been detected and reported using various imaging modalities. T1-weighted imaging (T1-WI) can depict thrombi as hyperintense signals within vessels. Moreover, in addition to thrombi, T1-WI hyperintensities in arteries may suggest arterial dissection. Read More

    Presence of Concomitant Systemic Cancer is Not Associated with Worse Functional Long-Term Outcome in Patients with Intracerebral Hemorrhage.
    Cerebrovasc Dis 2017 3;44(3-4):186-194. Epub 2017 Aug 3.
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany.
    Background: Data on clinical characteristics and outcome of patients with intracerebral hemorrhage (ICH) and concomitant systemic cancer disease are very limited.

    Methods: Nine hundred and seventy three consecutive primary ICH patients were analyzed using our prospective institutional registry over a period of 9 years (2006-2014). We compared clinical and radiological parameters as well as outcome - scored using the modified Rankin Scale (mRS) and analyzed in a dichotomized fashion as favorable outcome (mRS = 0-3) and unfavorable outcome (mRS = 4-6) - of ICH patients with and without cancer. Read More

    A Novel Evaluation for Predicting Aortic Complicated Lesions Using Calcification on Chest X-ray.
    Cerebrovasc Dis 2017 28;44(3-4):169-178. Epub 2017 Jul 28.
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
    Background: The aorta is a significant source of cerebral thromboembolisms. Aortic complicated lesions (ACLs) are key findings on transesophageal echocardiography (TEE) for assessing aortic sources of emboli to the brain. TEE is sometimes avoided due to its invasiveness. Read More

    Pulmonary Arteriovenous Malformations Are Associated with Silent Brain Infarcts in Hereditary Hemorrhagic Telangiectasia Patients.
    Cerebrovasc Dis 2017 27;44(3-4):179-185. Epub 2017 Jul 27.
    Department of Radiology, Mayo Clinic, Rochester, MN, USA.
    Background And Purpose: There is a high prevalence of right-to-left shunting pulmonary arteriovenous malformations (PAVMs), which are stroke risk factors, in hereditary hemorrhagic telangiectasia (HHT) patients. While the prevalence of ischemic complications in HHT patients is known, the prevalence of silent brain infarcts (SBI) remains unknown. The purpose of this study was to determine the prevalence and risk factors for SBI in HHT patients. Read More

    Free Fatty Acid Is Associated with Thrombogenicity in Cardioembolic Stroke.
    Cerebrovasc Dis 2017 18;44(3-4):160-168. Epub 2017 Jul 18.
    Department of Neurology and Stroke Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Background: Recently, the role of free fatty acids (FFAs) in thromboembolism has re-emerged in the context of cardioembolic stroke. Therefore, we attempted to determine the role of FFAs in embolic risk in various potential sources of cardioembolism (PSCE). We hypothesized that if elevated FFA levels in stroke patients are associated with thrombogenesis, then patients with a well-known high risk of embolic sources would have high FFA levels. Read More

    Optimal Medical Management Reduces Risk of Disease Progression and Ischemic Events in Asymptomatic Carotid Stenosis Patients: A Long-Term Follow-Up Study.
    Cerebrovasc Dis 2017 8;44(3-4):150-159. Epub 2017 Jul 8.
    Division of Cardiovascular Diseases, University of Kansas Medical Center, Kansas City, KS, USA.
    Background And Purpose: To assess the effect of optimal medical management including atherosclerotic risk factor control on ischemic stroke (IS), transient ischemic attack (TIA), carotid revascularization (CRV), and progression of severity of carotid stenosis (PSCS) in patients with asymptomatic carotid artery stenosis (ACAS).

    Methods: We conducted a retrospective analysis of patients with ACAS (who had at least 3 serial carotid duplex ultrasounds) for incidence of IS, TIA, and PSCS.

    Results: Eight hundred sixty-four patients with a mean follow-up duration of 79 ± 36 months were included. Read More

    Early Change in Stroke Size Performs Best in Predicting Response to Therapy.
    Cerebrovasc Dis 2017 7;44(3-4):141-149. Epub 2017 Jul 7.
    Neuro Vascular Brain Imaging Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
    Background: Reliable imaging biomarkers of response to therapy in acute stroke are needed. The final infarct volume and percent of early reperfusion have been used for this purpose. Early fluctuation in stroke size is a recognized phenomenon, but its utility as a biomarker for response to therapy has not been established. Read More

    A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review.
    Cerebrovasc Dis 2017 21;44(3-4):135-140. Epub 2017 Jun 21.
    Graduate School of Health Sciences, Brain Research Institute, Niigata University, Niigata, Japan.
    Objective: Reporting a novel mutation in the HTRA1 gene in a CARASIL patient from Americas.

    Methods: Clinical presentation and neuroimaging were consistent with CARASIL. HTRA1 DNA sequencing was performed using advanced ("next generation") sequencing technology. Read More

    Should We Screen for Janus Kinase 2 V617F Mutation in Cerebral Venous Thrombosis?
    Cerebrovasc Dis 2017 14;44(3-4):97-104. Epub 2017 Jun 14.
    Department of Neurology, S. Giovanni Calibita-Fatebenefratelli Hospital, Rome, Italy.
    Background: The presence of Janus Kinase 2 (JAK2) V617F mutation represents a major diagnostic criterion for detecting myeloproliferative neoplasms (MPN) and even in the absence of overt MPN, JAK2 V617F mutation is associated with splanchnic vein thrombosis. However, the actual prevalence and diagnostic value of the JAK2 V617F mutation in patients with cerebral venous thrombosis (CVT) are not known. The aims of this study were to assess the prevalence of JAK2 V617F mutation in a large group of consecutive CVT patients, to detect clinical, biological, and radiological features associated with the mutation, and to determine the long-term venous thrombosis recurrence rate in CVT patients with JAK2 mutation but without overt MPN in order to recommend the best preventive treatment. Read More

    Incomplete Large Vessel Occlusions in Mechanical Thrombectomy: An Independent Predictor of Favorable Outcome in Ischemic Stroke.
    Cerebrovasc Dis 2017 13;44(3-4):113-121. Epub 2017 Jun 13.
    Department of Neuroradiology, University Hospital Cologne, Cologne, Germany.
    Background And Purpose: Cerebral large vessel occlusion (LVO) in acute ischemic stroke (AIS) may be complete (CLVO) or incomplete (ILVO). The influence of ILVO on clinical outcome after mechanical thrombectomy (MT) remains unclear. We investigated primarily the clinical outcome in patients with AIS due to ILVO or CLVO. Read More

    Electroencephalography Patterns and Prognosis in Acute Ischemic Stroke.
    Cerebrovasc Dis 2017 13;44(3-4):128-134. Epub 2017 Jun 13.
    Neurovascular Service, Department of Neurology, University of Campinas, Campinas, Brazil.
    Background And Purpose: The prognostic significance of interictal epileptiform discharges (IED) and periodic patterns (PP) after ischemic stroke has not been assessed. We sought to test whether IED and PP, detected on standard Electroencephalography (EEG) performed during the acute phase of ischemic stroke are associated with a worse functional outcome.

    Methods: One-hundred-fifty-seven patients 18 years or older with a diagnosis of acute ischemic stroke presenting within 72 h from stroke onset were prospectively enrolled and followed. Read More

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