Search our Database of Scientific Publications and Authors

I’m looking for a

    3034 results match your criteria Cerebrovascular Diseases[Journal]

    1 OF 61

    Endotracheal Intubation and In-Hospital Mortality after Intracerebral Hemorrhage.
    Cerebrovasc Dis 2018 Jun 13;45(5-6):270-278. Epub 2018 Jun 13.
    Department of Neurology, Stroke Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
    Background: Many patients with acute intracerebral hemorrhages (ICHs) undergo endotracheal intubation with subsequent mechanical ventilation (MV) for "airway protection" with the intent to prevent aspiration, pneumonias, and its related mortality. Conversely, these procedures may independently promote pneumonia, laryngeal trauma, dysphagia, and adversely affect patient outcomes. The net benefit of intubation and MV in this patient cohort has not been systematically investigated. Read More

    Low Morbidity after Extracranial-Intracranial Bypass Operation. The Danish Extracranial-Intracranial Bypass Study: A Nationwide Survey.
    Cerebrovasc Dis 2018 Jun 7;45(5-6):252-257. Epub 2018 Jun 7.
    Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.
    Background: Patients with symptomatic atherosclerotic carotid artery occlusion (SACAO) have a high risk of a recurrent stroke. Extracranial-intracranial bypass (EC-IC bypass) has been shown not to improve outcome compared with medical treatment alone because long-term prevention of recurrent stroke in operated patients was offset by high perioperative stroke rates. We report our experience with EC-IC bypass operated at an experienced high-volume centre. Read More

    Flip-Flop Phenomenon: Swallowing-Induced Arterial Displacement as an Indicator of Carotid Artery Disease.
    Cerebrovasc Dis 2018 Jun 7;45(5-6):258-262. Epub 2018 Jun 7.
    Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
    Background And Purpose: The dynamic displacement of the carotid arteries with interference of the hyoid bone during swallowing, named as "flip-flop" phenomenon (FFP), may be associated with ischemic stroke. However, the extent to which FFP is prevalent in carotid artery disease remains unknown. We aimed to investigate its exact prevalence to explore the relationship between FFP and carotid artery disease. Read More

    Tenacity of Collateral Perfusion in Proximal Cerebral Arterial Occlusions 6-12 h after Onset.
    Cerebrovasc Dis 2018 Jun 7;45(5-6):263-269. Epub 2018 Jun 7.
    Department of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
    Background: Clinical trials have shown that benefits of endovascular recanalization (EVT) for acute ischemic stroke patients with sizable penumbral tissues seems plausible even beyond 6 h after their last seen normal (LSN). Persistency of ischemic penumbra remains unclear in delayed periods.

    Methods: From a prospective stroke registry database, we identified 111 acute ischemic stroke patients who had internal carotid artery or middle cerebral artery occlusion with baseline National Institutes of Health Stroke Scale scores ≥6 points and arrived 6-12 h after LSN. Read More

    Target Door-to-Needle Time for Tissue Plasminogen Activator Treatment with Magnetic Resonance Imaging Screening Can Be Reduced to 45 min.
    Cerebrovasc Dis 2018 May 29;45(5-6):245-251. Epub 2018 May 29.
    Department of Radiology, St. Jean Hospital, Perpignan, France.
    Objective: The purpose of this study was to demonstrate that the median door-to-needle (DTN) time for intravenous tissue plasminogen activator (tPA) treatment can be reduced to 45 min in a primary stroke centre with MRI-based screening for acute ischaemic stroke (AIS).

    Methods: From February 2015 to February 2017, the stroke unit of Perpignan general hospital, France, implemented a quality-improvement (QI) process. During this period, patients who received tPA within 4. Read More

    Wake-Up Stroke versus Stroke with Known Onset Time: Clinical and Multimodality CT Imaging Characteristics.
    Cerebrovasc Dis 2018 May 17;45(5-6):236-244. Epub 2018 May 17.
    Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
    Background: Current guidelines for the treatment of acute ischemic stroke are mainly based on the time between symptom onset and initiation of treatment. This time is unknown in patients with wake-up stroke (WUS). We investigated clinical and multimodality CT imaging characteristics on admission in patients with WUS and in patients with a stroke with a known onset time. Read More

    Undertreatment of Vascular Risk Factors in Patients with Monocular Ischaemic Visual Loss.
    Cerebrovasc Dis 2018 May 17;45(5-6):228-235. Epub 2018 May 17.
    Background And Purpose: Ischaemic visual loss is often considered a lower risk factor than other transient ischaemic attacks (TIA). We aimed to determine the recurrence risk, prevalence and management of vascular risk factors in these patients.

    Methods: The study took place in the University College Hospital London daily TIA clinic, main referral centre for North-Central London and Moorfields Eye Hospital. Read More

    Neutrophil-Lymphocyte Ratio Predicts Functional and Safety Outcomes after Endovascular Treatment for Acute Ischemic Stroke.
    Cerebrovasc Dis 2018 May 15;45(5-6):221-227. Epub 2018 May 15.
    Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China.
    Background And Objective: Endovascular treatment (EVT) is proven to be safe and effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic stroke. This study aims to explore the relationship between NLR and the clinical outcomes of LVOS patients undergoing EVT. Read More

    Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial.
    Cerebrovasc Dis 2018 Apr 27;45(5-6):213-220. Epub 2018 Apr 27.
    Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
    Background: Debate exists as to whether statin pretreatment confers an increased risk of 90-day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis. We assessed the effects of undifferentiated lipid-lowering pretreatment on outcomes and interaction with low-dose versus standard-dose alteplase in a post hoc subgroup -analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study.

    Methods: In all, 3,284 thrombolysis-eligible AIS patients (mean age 66. Read More

    Patent Foramen Ovale and Cryptogenic Stroke or Transient Ischemic Attack: To Close or Not to Close? A Systematic Review and Meta-Analysis.
    Cerebrovasc Dis 2018 Apr 12;45(5-6):193-203. Epub 2018 Apr 12.
    Department of Experimental and Clinical Medicine, Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
    Background: The optimal strategy of secondary stroke prevention in patients with patent foramen ovale (PFO) is controversial. This study was performed to evaluate the efficacy and safety of the device closure (DC) versus the medical therapy (MT) in patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO.

    Summary: Randomized controlled trials with active and control groups receiving the DC plus MT and MT alone in patients with history of cryptogenic stroke/TIA and diagnosis of PFO were systematically searched. Read More

    Diagnosis of Hyperacute and Acute Ischaemic Stroke: The Potential Utility of Exosomal MicroRNA-21-5p and MicroRNA-30a-5p.
    Cerebrovasc Dis 2018 Apr 6;45(5-6):204-212. Epub 2018 Apr 6.
    Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
    Background: Early and accurate diagnosis of ischaemic stroke (IS) requires the use of an optimized biomarker. Exosomal microRNAs have the potential to serve as biomarkers owing to their stability and specificity. We investigated the expression levels of plasma-derived exosomal microRNA-21-5p and microRNA-30a-5p in the different phases of IS. Read More

    The Serotonin Transporter Gene Polymorphisms and Risk of Ischemic Stroke.
    Cerebrovasc Dis 2018 3;45(3-4):187-192. Epub 2018 Apr 3.
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
    Introduction: Serotonin is known as a neurotransmitter; however, it also plays an important role in platelet aggregation as it is released upon platelet activation. The serotonin transporter (SERT) is responsible for the uptake of serotonin into platelets. Functional polymorphisms in the SERT gene may influence platelet activity, as they result in different levels of transporters and thereby different levels of serotonin in platelets. Read More

    Prevention Effect of Antiplatelets on Aneurysm Rupture in a Mouse Intracranial Aneurysm Model.
    Cerebrovasc Dis 2018 3;45(3-4):180-186. Epub 2018 Apr 3.
    Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background And Purpose: Subarachnoid hemorrhage (SAH) from intracranial aneurysm rupture results in significant morbidity and mortality. In the present study, we examined the effect of most widely used antiplatelet drugs, aspirin and cilostazol, on aneurysm rupture prevention using a mouse intracranial aneurysm model.

    Materials And Methods: Intracranial aneurysms were induced by a combination of deoxycorticosterone acetate-salt and a single injection of elastase into the cerebrospinal fluid in mice. Read More

    Associations between Pre-Admission Risk Scores and Two-Year Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients with Non-Valvular Atrial Fibrillation.
    Cerebrovasc Dis 2018 29;45(3-4):170-179. Epub 2018 Mar 29.
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
    Background: We aimed to clarify associations between pre-admission risk scores (CHADS2, CHA2DS2-VASc, and HAS-BLED) and 2-year clinical outcomes in ischemic stroke or transient ischemic attack (TIA) patients with non-valvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry.

    Methods: From 18 Japanese stroke centers, ischemic stroke or TIA patients with NVAF hospitalized within 7 days after onset were enrolled. Outcome measures were defined as death/disability (modified Rankin Scale score ≥3) at 2 years, 2-year mortality, and ischemic or hemorrhagic events within 2 years. Read More

    Transcatheter Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke: A Meta-Analysis of Randomized Controlled Trials.
    Cerebrovasc Dis 2018 29;45(3-4):162-169. Epub 2018 Mar 29.
    Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan, USA.
    Background: Patent foramen ovale (PFO) with atrial septal aneurysm is suggested as an important potential source for cryptogenic strokes. Percutaneous PFO closure to reduce the recurrence of stroke compared to medical therapy has been intensely debated. The aim of this study is to assess whether PFO closure in patients with cryptogenic stroke is safe and effective compared with medical therapy. Read More

    Fisetin Protects against Intracerebral Hemorrhage-Induced Neuroinflammation in Aged Mice.
    Cerebrovasc Dis 2018 27;45(3-4):154-161. Epub 2018 Mar 27.
    Anhui Medical University, Hefei, China.
    Background: Fisetin is commonly used as an anti-inflammatory and neuroprotective drug. In this study, we aimed to investigate the efficacy of fisetin in alleviating intracerebral hemorrhage (ICH)-induced brain injury.

    Methods: Mouse ICH models were constructed using the collagenase-induction method. Read More

    A Network-Wide Stroke Team Program Reduces Time to Treatment for Endovascular Stroke Therapy in a Regional Stroke-Network.
    Cerebrovasc Dis 2018 27;45(3-4):141-148. Epub 2018 Mar 27.
    Department of Neurology, Frankfurt University Hospital, Frankfurt am Main, Germany.
    Background And Purpose: Driven by the positive results of randomized, controlled trials of endovascular stroke therapies (EVT) in stroke patients with large vessel occlusion, different approaches to speed up the workflow for EVT candidates are currently being implemented worldwide. We aimed to assess the effect of a simple stroke network-wide workflow improvement project, primarily focusing on i.v. Read More

    Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone.
    Cerebrovasc Dis 2018 20;45(3-4):115-123. Epub 2018 Mar 20.
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
    Background: Uric acid (UA), an antioxidant with neuroprotective effects, favorably affects stroke outcome. However, the effect has not been examined in patients treated with edaravone, a frequently used free radical scavenger. We investigated whether the use of edaravone affected the relationship between UA levels and outcome in acute ischemic stroke. Read More

    Lateral Medullary Infarction with or without Extra-Lateral Medullary Lesions: What Is the Difference?
    Cerebrovasc Dis 2018 20;45(3-4):132-140. Epub 2018 Mar 20.
    Departments of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Background: Lateral medullary infarction (LMI) is not an uncommon disease. Although lesions are usually restricted to the lateral medullary area, some patients have additional infarcts in other parts of the brain. The clinical features and prognosis of isolated LMI (pure LMI, LMIpr) have been investigated. Read More

    Amyloid Angiopathy in Brain Hemorrhage: A Postmortem Neuropathological-Magnetic Resonance Imaging Study.
    Cerebrovasc Dis 2018 20;45(3-4):124-131. Epub 2018 Mar 20.
    INSERM LVTS (Laboratory for Vascular Translational Science) 1148 and Paris-Diderot University, Sorbonne Paris Cité, Paris, France.
    Background: Risk factors for intracerebral hemorrhage (ICH) include hypertension and cerebral amyloid angiopathy (CAA). The objective of this study was to determine the autopsy prevalence of CAA and the potential overlap with other risk factors among patients who died from ICH and also the correlation of CAA with cerebral microbleeds.

    Methods: We analyzed 81 consecutive autopsy brains from patients with ICH. Read More

    Stroke Referrals from Nursing Homes: High Rate of Mimics and Late Presentation.
    Cerebrovasc Dis 2018 14;45(3-4):109-114. Epub 2018 Mar 14.
    Department of Neurology, Medical University of Graz, Graz, Austria.
    Background: Stroke has become a treatable condition with increasing evidence of treatment benefits in older people. However, stroke mimics in geriatric patients are especially prevalent, causing incorrect suspicion and consecutive burden to patients and emergency room resources. We therefore examined the dimension of this problem by investigating emergency room admissions from nursing homes for suspected stroke. Read More

    The Effect of Improved Dysphagia Care on Outcome in Patients with Acute Stroke: Trends from 8-Year Data of a Large Stroke Register.
    Cerebrovasc Dis 2018 13;45(3-4):101-108. Epub 2018 Mar 13.
    Department of Neurology, University of Muenster, Muenster, Germany.
    Background: Early dysphagia screening and appropriate management are recommended by current guidelines to reduce complications and case fatality in acute stroke. However, data on the potential benefit of changes in dysphagia care on patient outcome are limited. Our objective was to assess the degree of implementation of dysphagia guidelines and determine the impact of modifications in dysphagia screening and treatment practices on disease complications and outcome in stroke patients over time. Read More

    Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema.
    Cerebrovasc Dis 2018 13;45(3-4):93-100. Epub 2018 Mar 13.
    Department of Neurology, University of Arizona College of Medicine, Tucson, Arizona, USA.
    Background: Apparent diffusion coefficient (ADC) imaging is a biomarker of cytotoxic injury that predicts edema formation and outcome after ischemic stroke. It therefore has the potential to serve as a "tissue clock" to describe the extent of ischemic injury and potentially predict response to therapy. The goal of this study was to determine the relationship between baseline ADC signal intensity, revascularization, and edema formation. Read More

    Contralesional Brain Activity in Acute Ischemic Stroke.
    Cerebrovasc Dis 2018 6;45(1-2):85-92. Epub 2018 Mar 6.
    Clinical Neurophysiology, University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine, Enschede, the Netherlands.
    Background: The noninjured, contralateral hemisphere is increasingly acknowledged in the process of recovery from acute ischemic stroke. We estimated the value of conventional electroencephalography (EEG) recordings for identifying contralateral hemisphere involvement in relation to functional recovery.

    Methods: We analyzed 2-min epochs from 21 electrode EEG registrations of 18 patients with acute hemispheric ischemic stroke and compared with 18 age-matched controls. Read More

    Default Mode Network Disruption in Stroke-Free Patients with Atrial Fibrillation.
    Cerebrovasc Dis 2018 2;45(1-2):78-84. Epub 2018 Mar 2.
    Department of Neurology, Neuroimaging Laboratory, University of Campinas, UNICAMP, Campinas, Brazil.
    Background: Atrial fibrillation (AF) is a widely accepted risk for causing stroke. However, recent studies show AF as a risk factor for dementia, even without causing stroke. The mechanisms by which dementia develops in stroke-free patients with AF are still poorly understood and the association of AF with abnormal function of brain networks activities, such as the default mode network (DMN), has not been previously studied. Read More

    Natural History of Vertebrobasilar Dolichoectatic and Fusiform Aneurysms: A Systematic Review and Meta-Analysis.
    Cerebrovasc Dis 2018 13;45(1-2):68-77. Epub 2018 Feb 13.
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
    Background And Purpose: Vertebrobasilar non-saccular and dolichoectatic aneurysms (VBDA) are a rare type of aneurysm and are generally associated with poor prognosis. In order to better characterize the natural history of VBDAs, we performed a systematic review and meta-analysis of the literature to determine rates of mortality, growth, rupture, ischemia, and intraparenchymal hemorrhage.

    Materials And Methods: We searched the literature for longitudinal natural history studies of VBDA patients reporting clinical and imaging outcomes. Read More

    Sensitive Detection of Atrial Fibrillation in Acute Stroke Patients by Short-Term Bedside Electrocardiography Monitoring Software Analysis.
    Cerebrovasc Dis 2018 17;45(1-2):54-60. Epub 2018 Jan 17.
    Department of Neurology, University Hospital of Muenster, Muenster, Germany.
    Background: Atrial fibrillation (AF) is an important cause of stroke. Continuous electrocardiography (ECG) monitoring with software-based analysis algorithms has been suggested to enhance the AF detection rate. We investigated the ability of stroke risk analysis (SRA) in the detection of AF in acute stroke patients. Read More

    When to Screen Ischaemic Stroke Patients for Cancer.
    Cerebrovasc Dis 2018 9;45(1-2):42-47. Epub 2018 Jan 9.
    Department of Clinical Medicine, University of Bergen, Bergen, Norway.
    Background And Purpose: Ischemic stroke can be the first manifestation of cancer and it is therefore important to ascertain which stroke patients should be considered for cancer-diagnostic investigations. We aimed to determine the frequency of active cancer in patients with acute ischemic stroke and to compare clinical findings in stroke patients with active cancer to ischemic stroke patients with no history of cancer. Finally, we aimed to develop a predictive and feasible score for clinical use to uncover underlying malignancy. Read More

    Black Hole Sign Predicts Poor Outcome in Patients with Intracerebral Hemorrhage.
    Cerebrovasc Dis 2018 10;45(1-2):48-53. Epub 2018 Jan 10.
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Background: In spontaneous intracerebral hemorrhage (ICH), black hole sign has been proposed as a promising imaging marker that predicts hematoma expansion in patients with ICH. The aim of our study was to investigate whether admission CT black hole sign predicts hematoma growth in patients with ICH.

    Methods: From July 2011 till February 2016, patients with spontaneous ICH who underwent baseline CT scan within 6 h of symptoms onset and follow-up CT scan were recruited into the study. Read More

    Computed Tomography Perfusion Derived Blood-Brain Barrier Permeability Does Not Yet Improve Prediction of Hemorrhagic Transformation.
    Cerebrovasc Dis 2018 8;45(1-2):26-32. Epub 2018 Jan 8.
    Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
    Introduction: Hemorrhagic transformation (HT) in acute ischemic stroke can occur as a result of reperfusion treatment. While withholding treatment may be warranted in patients with increased risk of HT, prediction of HT remains difficult. Nonlinear regression analysis can be used to estimate blood-brain barrier permeability (BBBP). Read More

    Predictors for Mortality after Mechanical Thrombectomy of Acute Basilar Artery Occlusion.
    Cerebrovasc Dis 2018 30;45(1-2):61-67. Epub 2018 Jan 30.
    Department of Neurology, Stroke Center, Foch Hospital, Suresnes, France.
    Background: Modern endovascular thrombectomy (MET), using stent retrievers or large-bore distal aspiration catheters in stroke patients with acute basilar artery occlusion (BAO), is routinely performed to date. However, more than 35% of BAO patients treated with MET die within 90 days despite high recanalization rates. The purpose of this study is to investigate the parameters associated with 90-day mortality in patients with BAO after MET. Read More

    Primary Prevention of Stroke in Chronic Kidney Disease Patients: A Scientific Update.
    Cerebrovasc Dis 2018 9;45(1-2):33-41. Epub 2018 Jan 9.
    Department of Nephrology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Background: Although chronic kidney disease (CKD) is an independent risk factor for stroke, official recommendations for the primary prevention of stroke in CKD are generally lacking.

    Summary: We searched PubMed and ISI Web of Science for randomised controlled trials, observational studies, reviews, meta-analyses and guidelines referring to measures of stroke prevention or to the treatment of stroke-associated risk factors (cardiovascular disease in general and atrial fibrillation (AF), arterial hypertension or carotid artery disease in particular) among the CKD population. The use of oral anticoagulation in AF appears safe in non-end stage CKD, but it should be individualized and preferably based on thromboembolic and bleeding stratification algorithms. Read More

    Carotid Artery Stenosis Contralateral to Acute Tandem Occlusion: An Independent Predictor of Poor Clinical Outcome after Mechanical Thrombectomy with Concomitant Carotid Artery Stenting.
    Cerebrovasc Dis 2018 24;45(1-2):10-17. Epub 2017 Nov 24.
    Department of Neuroradiology, University Hospital of Aachen, Aachen, Germany.
    Background And Purpose: Cerebral ischemic strokes due to extra-/intracranial tandem occlusions (TO) of the anterior circulation are responsible for causing mechanical thrombectomy (MT). The impact of concomitant contralateral carotid stenosis (CCS) upon outcome remains unclear in this stroke subtype.

    Methods: Retrospective analysis of prospectively collected data of 4 international stroke centers between 2011 and 2017. Read More

    High Systolic Blood Pressure after Successful Endovascular Treatment Affects Early Functional Outcome in Acute Ischemic Stroke.
    Cerebrovasc Dis 2018 24;45(1-2):18-25. Epub 2017 Nov 24.
    Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
    Background: Endovascular treatment (EVT) has been shown to significantly improve functional outcome in patients with acute large cerebral vessel occlusions. To date, no evidence-based recommendations on blood pressure management after successful EVT exist. Previous studies showed an association between high pre-EVT systolic blood pressure (SBP) and functional outcome, but do not answer the question on how to manage blood pressure after successful recanalization. Read More

    Acute Kidney Injury Following Acute Ischemic Stroke and Intracerebral Hemorrhage: A Meta-Analysis of Prevalence Rate and Mortality Risk.
    Cerebrovasc Dis 2018 24;45(1-2):1-9. Epub 2017 Nov 24.
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Background: The epidemiology of acute renal dysfunction after stroke is routinely overlooked following stroke events. Our aim in this meta-analysis is to report the prevalence of acute kidney injury (AKI) following acute stroke and its impact on mortality.

    Methods: A systematic literature search was performed on PubMed, EMBASE and Google Scholar for observational studies examining the prevalence and mortality risk of stroke patients with AKI as a complication. Read More

    Ischemic Stroke: Histological Thrombus Composition and Pre-Interventional CT Attenuation Are Associated with Intervention Time and Rate of Secondary Embolism.
    Cerebrovasc Dis 2017 31;44(5-6):344-350. Epub 2017 Oct 31.
    Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
    Background And Purpose: The introduction of stent retrievers has made the complete extraction and histological analysis of human thrombi possible. A number of large randomized trials have proven the efficacy of thrombectomy for ischemic stroke; however, thrombus composition could have an impact on the efficacy and risk of the intervention. We therefore investigated the impact of histologic thrombus features on interventional outcome and procedure-related embolisms. Read More

    Prehospital Computed Tomography Angiography in Acute Stroke Management.
    Cerebrovasc Dis 2017 31;44(5-6):338-343. Epub 2017 Oct 31.
    Department of Neurology, Saarland University Medical Center, Homburg, Germany.
    Background: An ambulance equipped with a computed tomography (CT) scanner, a point-of-care laboratory, and telemedicine capabilities (mobile stroke unit [MSU]) has been shown to enable the delivery of thrombolysis to stroke patients directly at the emergency site, thereby significantly decreasing time to treatment. However, work-up in an MSU that includes CT angiography (CTA) may also potentially facilitate triage of patients directly to the appropriate target hospital and specialized treatment, according to their individual vascular pathology.

    Methods: Our institution manages a program investigating the prehospital management of patients with suspicion of acute stroke. Read More

    Influence of Renal Function on Treatment Results after Stroke Thrombectomy.
    Cerebrovasc Dis 2017 31;44(5-6):351-358. Epub 2017 Oct 31.
    Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
    Background: Renal dysfunction (RD) may be associated with poor outcome in ischemic stroke patients treated with mechanical thrombectomy (MT), but data concerning this important and emerging comorbidity do not exist so far. Here, we investigated the influence of RD on postprocedural intracerebral hemorrhage (ICH), clinical outcome, and mortality in a large prospectively collected cohort of acute ischemic stroke patients treated with MT.

    Methods: Consecutive patients with anterior-circulation stroke treated with MT between October 2010 and January 2016 were included. Read More

    Early Cognitive Impairment after Intracerebral Hemorrhage in the INTERACT1 Study.
    Cerebrovasc Dis 2017 26;44(5-6):320-324. Epub 2017 Oct 26.
    The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
    Background: Data on cognitive impairment after acute intracerebral hemorrhage (ICH) are limited. This study is aimed at determining the frequency and predictors of cognitive impairment among participants of the pilot phase, Intensive Blood Pressure (BP) Reduction in Acute Cerebral Hemorrhage Trial (INTERACT1).

    Methods: INTERACT1 was an open randomized trial of early intensive (target systolic BP <140 mm Hg) compared with contemporaneous guideline-recommended BP lowering in 404 patients with elevated systolic BP (150-220 mm Hg) within 6 h of ICH onset. Read More

    Serum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled Diabetes.
    Cerebrovasc Dis 2017 26;44(5-6):325-329. Epub 2017 Oct 26.
    Human Health Science, Graduate School of Medicine and Faculty of Medicine Kyoto University, Kyoto, Japan.
    Background: Serum 1,5-anhydroglucitol (1,5-AG) levels are a measure that provides information on daily glycemic variations. We evaluated whether 1,5-AG could be a possible marker of acute ischemic stroke (AIS) or transient ischemic attacks (TIA) in patients with diabetes mellitus (DM).

    Methods: We retrospectively reviewed electronic medical records of 5,294 AIS/TIA patients. Read More

    Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study.
    Cerebrovasc Dis 2017 26;44(5-6):330-337. Epub 2017 Oct 26.
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience (MHeNs), Alzheimer Center Limburg, Maastricht, the Netherlands.
    Background: Poststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA. Read More

    Early Rebleeding after Brain Arteriovenous Malformation Rupture, Clinical Impact and Predictive Factors: A Monocentric Retrospective Cohort Study.
    Cerebrovasc Dis 2017 3;44(5-6):304-312. Epub 2017 Oct 3.
    Paris VI University, Pierre et Marie Curie, Paris, France.
    Background: Brain arteriovenous malformations (BAVMs) are a leading cause of intracranial hemorrhage in young adults. This study aimed to identify individual predictive factors of early rebleeding after BAVM rupture and determine its impact on prognosis.

    Methods: Early rebleeding was defined as a spontaneous intracranial hemorrhage within 30 days of BAVM rupture in patients with nonobliterated BAVMs. Read More

    Cerebral Cavernous Malformations: Patient-Reported Outcome Validates Conservative Management.
    Cerebrovasc Dis 2017 3;44(5-6):313-319. Epub 2017 Oct 3.
    Department of Surgery, Division of Neurosurgery, Hospital Universitário Clementino Fraga Filho and Program of Post-Graduation in Surgical Sciences of the Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Cerebral cavernous malformations (CCM) are clusters of dilated sinusoidal channels lined by a single layer of endothelium. In contradistinction to arteriovenous malformations, these lesions do not have smooth muscle or elastin in their lining and they are angiographically occult, and the MRI is the most sensitive test for CCM detection. CCM are one of the most prevalent vascular malformations of the central nervous system, affecting about 0. Read More

    Ischemic Stroke Patients Demonstrate Increased Carotid Plaque Microvasculature Compared to (Ocular) Transient Ischemic Attack Patients.
    Cerebrovasc Dis 2017 26;44(5-6):297-303. Epub 2017 Sep 26.
    Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
    Background: Patients with a recent ischemic stroke have a higher risk of recurrent stroke compared to (ocular) transient ischemic attack (TIA) patients. Plaque microvasculature is considered as a feature of plaque vulnerability and can be quantified with carotid dynamic contrast-enhanced MRI (DCE-MRI). The purpose of this cross-sectional study was to explore the association between plaque microvasculature and the type of recent cerebrovascular events in symptomatic patients with mild-to-moderate carotid stenosis. Read More

    1 OF 61