132,402 results match your criteria Cerebrovascular Diseases[Journal]


Middle Meningeal Artery to Premeatal Anterior Inferior Cerebellar Artery Bypass Via Anterior Petrosectomy: An Anatomic Feasibility Study.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurological Surgery, University of California, San Francisco, California, USA; Skull Base and Cerebrovascular Laboratory, University of California, San Francisco, California, USA. Electronic address: http://skullbaselab.ucsf.edu.

Introduction: Anterior-inferior cerebellar artery (AICA) aneurysms are rare with no optimal consensus on management strategies. When the treatment requires parent artery occlusion post-operative ischemic or neuropathic, complications can occur.

Objective: To evaluate the feasibility of direct revascularization of premeatal AICA using the middle meningeal artery (MMA) as the donor through an anterior petrosectomy (APA) window. Read More

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December 2018

Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients.

Rom J Intern Med 2018 Dec;56(4):257-264

Kharkiv National Medic University, Nauky Ave., Kharkiv, Ukraine.

Introduction: Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. Read More

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December 2018
1 Read

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

TOBB Economy and Technology University, Cardiology Department, Ankara, Turkey.

Background: Platelet to lymphocyte ratio (PLR) has been demonstrated as an risk and prognostic marker in many of cardiovascular diseases. Relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease. Read More

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December 2018

Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro.

Biomed Chromatogr 2018 Dec 5:e4454. Epub 2018 Dec 5.

Department of Pharmacy, Shanghai Jiao Tong University Affliated Sixth People's Hospital, Shanghai, P. R. China.

Danhong injection (DHI) is made from Salvia miltiorrhiza Bunge. and Carthamus tinctorius L. extract and is widely used in the clinical treatment of cardiovascular and cerebrovascular diseases. Read More

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December 2018
2 Reads

MRI Presentation of Infectious Intracranial Aneurysms in Infective Endocarditis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The radiographic appearance of infectious intracranial aneurysms (IIAs) of infective endocarditis (IE) on magnetic resonance imaging (MRI) of brain is varied. We aimed to describe the IIA-specific MRI features in a series of patients with IIAs.

Methods: Records of patients with active IE who had digital subtraction angiography (DSA) at a tertiary medical center from January 2011 to December 2016 were reviewed. Read More

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December 2018
1 Read

Cerebrovascular Function in the Large Arteries Is Maintained Following Moderate Intensity Exercise.

Front Physiol 2018 21;9:1657. Epub 2018 Nov 21.

Centre for Heart Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, BC, Canada.

Exercise has been shown to induce cerebrovascular adaptations. However, the underlying temporal dynamics are poorly understood, and regional variation in the vascular response to exercise has been observed in the large cerebral arteries. Here, we sought to measure the cerebrovascular effects of a single 20-min session of moderate-intensity exercise in the one hour period immediately following exercise cessation. Read More

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November 2018

Prevalence of poststroke depression in Iranian patients: a systematic review and meta-analysis.

Neuropsychiatr Dis Treat 2018 13;14:3073-3080. Epub 2018 Nov 13.

Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK.

Background: Poststroke depression (PSD) is the most common and important neuropsychiatric consequences of stroke, which can result in longer hospital stay, compromise the effectiveness of rehabilitation, and reduce the patients' quality of life. However, Iranian studies have reported different and conflicting prevalence rates for PSD.

Objective: The present systematic review and meta-analysis aimed to evaluate the overall prevalence of PSD in Iranian patients. Read More

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November 2018
2 Reads

The Chinese herbal formula Decoction attenuates cognitive impairment and protects cerebrovascular function in SAMP8 mice.

Neuropsychiatr Dis Treat 2018 9;14:3037-3051. Epub 2018 Nov 9.

Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China,

Purpose: This study was designed to explore the underlying mechanism of action for a Decoction (FQD) in Alzheimer's disease (AD), to validate its neuroprotective effects, and to provide experimental support for its predicted mechanism of action.

Methods: An integrative approach to network pharmacology was performed to predict the mechanism of action for treatment of AD with FQD. The predicted mechanism was validated in SAMP8 mice. Read More

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November 2018

Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients: the ESPRIT Study.

Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.

Cardiology Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

The optimal level of sodium intake remains controversial, and the effects on a broad range of cardiovascular (CV) conditions remain unknown. The Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients (ESPRIT) is a prospective observational study designed to investigate whether sodium intake assessed by spot urine testing is associated with adverse CV events. A total of 520 patients who visited our cardiology clinic with various cardiovascular risk profiles were included. Read More

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December 2018

Zhongfenggao protects brain microvascular endothelial cells from oxygen-glucose deprivation/reoxygenation-induced injury by angiogenesis.

Biol Pharm Bull 2018 Dec 5. Epub 2018 Dec 5.

Department of encephalopathy, Gansu Provincial Hospital of Traditional Chinese Medicine.

Zhongfenggao (ZFG) is prescribed for the treatment of cerebrovascular diseases in critical projects of the State Administration of Traditional Chinese Medicine. ZFG has been found to nourish qi, activate blood circulation, remove blood stasis, dredge collaterals, and strengthen the brain and mind. The present study investigated the effects of ZFG on oxygen-glucose deprivation/reoxygenation (OGD/R) induced injury to brain microvascular endothelial cells (BMECs), and the mechanisms underlying such effects. Read More

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December 2018

Regression of White Matter Hyperintensity after Indirect Bypass Surgery in a Patient with Moyamoya Disease.

Magn Reson Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45.

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December 2018

TRPV4 channels stimulate Ca-induced Ca release in mouse neurons and trigger endoplasmic reticulum stress after intracerebral hemorrhage.

Brain Res Bull 2018 Nov 30. Epub 2018 Nov 30.

Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing medical university, Chongqing, 400016, China. Electronic address:

Individuals with intracerebral hemorrhage (ICH) suffer varying degrees of neurological dysfunction as a result of neuronal apoptosis, and thus, maintenance of neuronal survival may be crucial to prevent ICH brain injury. Here, we report that the expression of transient receptor potential vanilloid 4 (TRPV4) was upregulated in mouse neurons after ICH. The selective TRPV4 agonist GSK1016790 A aggravated neuronal death whereas the TRPV4 antagonist HC-067047 promoted neuronal survival after ICH. Read More

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November 2018

A systematic review of physical rehabilitation interventions for stroke in low and lower-middle income countries.

Disabil Rehabil 2018 Dec 3:1-29. Epub 2018 Dec 3.

a UCD School of Public Health, Physiotherapy and Population Science , University College Dublin , Dublin , Ireland.

Purpose: Approximately 70% of strokes occur in low and middle income countries, yet the effectiveness of physical rehabilitation in these contexts remains undetermined. This systematic review identifies and summarises the current evidence supporting physical rehabilitation interventions post-stroke in low and lower-middle income countries.

Methods: Five databases were comprehensively searched (April 2017) for randomised controlled trials, clinical controlled trials, and cohort studies testing rehabilitation interventions post-stroke in these countries. Read More

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December 2018

What Causes LVAD-Associated Ischemic Stroke? Surgery, Pump Thrombosis, Antithrombotics, and Infectionsa.

ASAIO J 2018 Nov 28. Epub 2018 Nov 28.

Cerebrovascular Center of the Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

Acute ischemic stroke (AIS) is a major complication in left ventricular assist device (LVAD) population. A better understanding of clinical risk factors associated with AIS may help mitigate risk of stroke. We reviewed prospectively collected data of 477 LVAD patients from a tertiary center from October 1, 2004 to December 31, 2016. Read More

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November 2018

Evaluation of Ocular Perfusion in Alzheimer's Disease Using Optical Coherence Tomography Angiography.

J Alzheimers Dis 2018 Nov 26. Epub 2018 Nov 26.

Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.

Background: There is increasing evidence for the involvement of cerebrovascular factors in Alzheimer's disease (AD).

Objective: To evaluate retinal and optic nerve head perfusion in patients with AD using optical coherence tomography angiography (OCTA), and to analyze the correlations of quantitative OCTA metrics with AD pathology and vascular cerebral lesions in AD patients.

Methods: 36 eyes of 36 patients with AD (study group) and 38 eyes of 38 healthy subjects (control group) were prospectively included in this study. Read More

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November 2018

Transcranial Doppler to detect right-to-left shunt in cryptogenic acute ischemic stroke.

Brain Behav 2018 Dec 1:e01091. Epub 2018 Dec 1.

Department of Neurology, Poitiers University Hospital, Poitiers Cedex, France.

Objectives: We aimed to confirm the sensitivity and specificity of contrast transcranial Doppler (cTCD) in the detection of right-to-left shunt (RLS) compared to the current reference standard (i.e., transesophageal echocardiography-TEE) in patients aged <55 years with a cryptogenic acute ischemic stroke (AIS) or high-risk (ABCD score ≥4) transient ischemic attack (TIA), and to calculate the real life delay in detecting RLS by cTCD versus TEE in a tertiary care academic stroke center. Read More

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December 2018
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Ultrasound assessment of carotid arteries: Current concepts, methodologies, diagnostic criteria, and technological advancements.

Echocardiography 2018 Dec;35(12):2079-2091

Department of Internal Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.

Following cardiac disease and cancer, stroke continues to be the third leading cause of death and disability due to chronic disease in the developed world. Appropriate screening tools are integral to early detection and prevention of major cardiovascular events. In a carotid artery, the presence of increased intima-media thickness, plaque, or stenosis is associated with increased risk of a transient ischemic attack or a stroke. Read More

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December 2018
1 Read

Network meta-analysis of antiplatelet therapy following coronary artery bypass grafting (CABG): none versus one versus two antiplatelet agents.

Ann Cardiothorac Surg 2018 Sep;7(5):577-585

The Collaborative Research (CORE) Group, Macquarie University, Sydney, Australia.

Background: Numerous agents have been trialed following coronary artery bypass grafting (CABG) to maintain long-term graft patency. While clear evidence exists for the use of aspirin in maintaining graft patency, the role of dual-antiplatelet therapy in CABG patients is not as well established. This network meta-analysis aimed to compare the short-term post-CABG graft patency outcomes for patients with none, one or two antiplatelet agents. Read More

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September 2018

Comparison of minimally invasive direct coronary artery bypass and drug-eluting stents for management of isolated left anterior descending artery disease: a systematic review and meta-analysis of 7,710 patients.

Ann Cardiothorac Surg 2018 Sep;7(5):567-576

Department of Cardiac Surgery, St. George's Hospital, London, UK.

Background: In the contemporary era of drug-eluting stents (DES) the issue of optimal revascularization strategy for patients with isolated disease of the left anterior descending (LAD) artery has gained more significance. We aimed to evaluate the current best evidence on the subject by performing a systematic review and meta-analysis of the studies comparing minimally invasive direct coronary artery bypass (MIDCAB) grafting with DES in patients with isolated LAD disease.

Methods: A literature search was conducted from 1966 through March 2018 using MEDLINE, EMBASE, and other scientific databases to identify relevant articles. Read More

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September 2018

Cerebral embolic protection devices during transcatheter aortic valve implantation: clinical versus silent embolism.

J Thorac Dis 2018 Nov;10(Suppl 30):S3604-S3613

Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.

Cerebrovascular events following transcatheter aortic valve implantation (TAVI) is one of the most devastating complications. Several studies with magnetic resonance or cerebral filters have demonstrated the universal brain embolization after TAVI, in the majority of patients clinically silent. Embolic protection devices (EPD) have been developed as a mechanical barrier to prevent these emboli to reach cerebral vasculature and potentially reduce neurological events. Read More

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November 2018

Risk for cardiovascular disease in patients with nontuberculous mycobacteria treated with macrolide.

J Thorac Dis 2018 Oct;10(10):5784-5795

Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Background: Macrolide antibiotics are the most important pharmacological agents for the treatment of nontuberculous mycobacterial disease. We investigated the incidence of acute cardiovascular events in patients taking macrolides for nontuberculous mycobacterial disease and determined the difference in risk between clarithromycin and azithromycin.

Methods: A population-based retrospective cohort study was conducted in South Korea using the Health Insurance Review and Assessment Service database. Read More

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October 2018

Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia.

Front Aging Neurosci 2018 16;10:376. Epub 2018 Nov 16.

Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.

Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking or speech problems. VaD is usually caused by cerebrovascular disease, during which, cerebrovascular endothelial cells (CECs) are vulnerable. CEC dysfunction occurs before the onset of VaD and can eventually lead to dysregulation of cerebral blood flow and blood-brain barrier damage, followed by the activation of glia and inflammatory environment in the brain. Read More

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November 2018

Multiple Combination of Angelica gigas Extract and Mesenchymal Stem Cells Enhances Therapeutic Effect.

Biol Pharm Bull 2018 ;41(12):1748-1756

Department of Biology Education, College of Education, Pusan National University.

Alternative medicines attract attention because stroke is rarely expected to make a full recovery with the most advanced medical technology. Angelica gigas (AG) is a well-known herbal medicine as a neuroprotective agent. The present study introduced mesenchymal stem cells (MSCs) to identify for the advanced treatment of the cerebrovascular disease. Read More

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January 2018

Paroxysmal sympathetic hyperactivity due to fourth ventricular tumor resection resulting in cerebrovascular constriction syndrome.

Neurol India 2018 Nov-Dec;66(6):1821-1822

Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

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December 2018

Hybrid Coronary Revascularization vs Complete Coronary Artery Bypass Grafting for Multivessel Coronary Artery Disease: A Systematic Review and Meta-Analysis.

J Invasive Cardiol 2018 Dec;30(12):E131-E149

Professor of Medicine, Jewish General Hospital/McGill University, 3755 Côte Ste-Catherine Road, Suite H-421.1, Montreal, Quebec, Canada H3T 1E2.

Background: Hybrid coronary revascularization (HCR) has emerged as a potential alternative to complete coronary artery bypass graft (CABG) surgery. However, the efficacy and safety of HCR vs CABG remain unclear. We therefore conducted a systematic review and meta-analysis to compare these interventions. Read More

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December 2018

Outcomes of Extracorporeal Membrane Oxygenation Support for Complex High-Risk Elective Percutaneous Coronary Interventions: A Single-Center Experience and Review of the Literature.

J Invasive Cardiol 2018 Dec;30(12):456-460

Minneapolis Heart Institute, 920 E. 28th Street #300, Minneapolis, MN 55407 USA.

Objectives: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is most commonly used in patients with cardiac arrest and cardiogenic shock. There are limited data on the use of VA-ECMO for elective, high-risk percutaneous coronary intervention (PCI). We examined the in-hospital and mid-term clinical outcomes in patients undergoing complex, high-risk PCI with VA-ECMO support. Read More

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December 2018

Patients Prescribed Direct-acting Oral Anticoagulants Have Low Risk of Post-Polypectomy Complications.

Clin Gastroenterol Hepatol 2018 Nov 29. Epub 2018 Nov 29.

Division of Gastroenterology, San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA, United States.

Background & Aims: Use of direct-acting oral anticoagulants (DOACs) is increasing, but little is known about the associated risks in patients undergoing colonoscopy with polypectomy. We aimed to determine the risk of post-polypectomy complications in patients prescribed DOACs.

Methods: We performed a retrospective analysis using the Clinformatics Data Mart Database (a de-identified administrative database from a large national insurance provider) to identify adults who underwent colonoscopy with polypectomy or endoscopic mucosal resection (EMR) from January 1, 2011, through December 31, 2015. Read More

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November 2018
3 Reads

Implementation of the stroke code registry in the emergency department of a regional hospital.

Enferm Clin 2018 Nov 28. Epub 2018 Nov 28.

Enfermeras de Urgencias, Fundación Sanitaria Mollet, Mollet del Vallès, Barcelona, España.

Stroke is a cerebrovascular disease caused by a decrease or abrupt obstruction of blood flow to the brain. Nerve cells do not receive oxygen and there is a transient or permanent alteration of the function of a certain region of the brain. It causes high morbidity and mortality resulting in disabilities with a large economic cost to society. Read More

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November 2018

Brazilian Analytical Decision Model for Cardiovascular Disease: An Adaptation of the Scottish Cardiovascular Disease Policy Model.

Value Health Reg Issues 2018 Nov 28;17:210-216. Epub 2018 Nov 28.

Health Economics and Health Technology Assessment, Institute of Health and Technology Assessment, University of Glasgow, Glasgow, UK.

Introduction: Despite the significant impact of cardiovascular disease (CVD), there is not yet an analytical decision tool for assessing efficiency of interventions to prevent primary CVD events in Brazil. Therefore, we sought to adapt a Scottish CVD Policy Model to be used in the proposed population.

Methods: Calibration consisted of identifying multiplicative factors for linear predictors of existing survival analysis models to produce predictions that closely match observed data (Life-table and Brazilian cohort study). Read More

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November 2018

Comprehensive Characterization of Cerebrovascular Dysfunction in Blast Traumatic Brain Injury Using Photoacoustic Microscopy.

J Neurotrauma 2018 Dec 1. Epub 2018 Dec 1.

University of Virginia, Biomedical Engineering, Charlottesville, Virginia, United States ;

Blast traumatic brain injury (bTBI) is a leading contributor to combat-related injuries and death. Although substantial emphasis has been placed on blast-induced neuronal and axonal injuries, co-existing dysfunctions in the cerebral vasculature, particularly the microvasculature, remain poorly understood. Here, we studied blast-induced cerebrovascular dysfunctions in a rat model of bTBI (blast overpressure: 187. Read More

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December 2018
3 Reads
3.714 Impact Factor

Inhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a, 27b, 148a, 298, and 451a levels.

Xenobiotica 2018 Dec 2:1-15. Epub 2018 Dec 2.

a Institute of Pharmacy and Chemistry, Dali Universit y, Yunnan , China.

1. Scutellarin is a flavonoid glycoside widely used in the treatment of cardio-cerebrovascular diseases in China. In this study, we investigated the effect of scutellarin on cytochrome P450 3A4 (CYP3A4) and CYP3A5 expression. Read More

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December 2018

Transcatheter Aortic Valve Replacement for Pure Native Aortic Valve Regurgitation: A Systematic Review.

Cardiology 2018 Dec 5;141(3):132-140. Epub 2018 Dec 5.

Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou,

Background: Transcatheter aortic valve replacement (TAVR) is a recent and an effective treatment option for high- or extreme-surgical-risk patients with symptomatic severe aortic stenosis. However, pure severe native aortic valve regurgitation (NAVR) without aortic stenosis remains a contraindication to TAVR. The aim of our systemic review analysis was to evaluate TAVR in patients with pure NAVR. Read More

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December 2018
1 Read

The changing profile of cerebrovascular diseases.

Authors:
Didier Leys

Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.

Univ-Lille, Inserm U1171, CHU Lille, Lille, France.

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December 2018

Examining the ocular fundus in neurology.

Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.

Indiana University School of Medicine.

Purpose Of Review: The funduscopic examination can be a technically difficult, and often omitted, portion of the neurologic examination, despite its great potential to influence patient care.

Recent Findings: Medical practitioners are often first taught to examine the ocular fundus using a direct ophthalmoscope, however, this skill requires frequent practice. Nonmydriatic tabletop and portable fundus photography and even smartphone-based photography offer alternative and practical means for approaching examination of the ocular fundus. Read More

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December 2018
1 Read

Subarachnoid Hemorrhage.

Continuum (Minneap Minn) 2018 Dec;24(6):1623-1657

Purpose Of Review: This article reviews the epidemiology, clinical presentation, diagnosis, and management of patients with aneurysmal subarachnoid hemorrhage (SAH). SAH is a type of hemorrhagic stroke and is a neurologic emergency with substantial morbidity and mortality. This article reviews the most common and potentially life-threatening neurologic and medical complications to promote their early recognition and prevent secondary brain injury. Read More

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December 2018
1 Read

Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.

J Cereb Blood Flow Metab 2018 Dec 5:271678X18815791. Epub 2018 Dec 5.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Hypertensive intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease with no effective treatment. Lysyl hydroxylase 3 (LH3) is essential for collagen IV intermolecular crosslinking and stabilization. Deficiency in LH3 affects the assembly and secretion of collagen IV and basement membrane (BM) integrity of vessels. Read More

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December 2018
6 Reads

The toxicology of air pollution predicts its epidemiology.

Inhal Toxicol 2018 Dec 5:1-8. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

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December 2018
6 Reads

Multisite vascular disease in acute coronary syndromes: increased in-hospital mortality and no improvement over time.

Eur Heart J Acute Cardiovasc Care 2018 Dec 5:2048872618814708. Epub 2018 Dec 5.

7 Division of Cardiology, St. Gallen County Hospital, St. Gallen, Switzerland.

Introduction:: Limited data are available on the impact of multisite artery disease in patients with acute coronary syndromes. In particular, it is unknown whether the outcomes of those high-risk patients have improved over time. Therefore, we addressed the multisite artery disease patient population enrolled in the Swiss nationwide prospective acute coronary syndromes cohort study AMIS Plus over two decades. Read More

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December 2018

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.

Metab Brain Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443000, China.

Allicin, one of the main biologically active compounds derived from garlic, was previously reported to possess multiple pharmacological activities. Whether allicin protected against chronic social defeat stress (CSDS) induced depressive-like behaviors remained unknown. Thus, our present study for the first time investigated the potential antidepressant effects and the mechanisms of allicin on the CSDS mice model. Read More

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December 2018

Assessment of the Prevalence of Vascular Anomalies of the Circle of Willis Based on the Autopsy of Cadavers in Kurdish Race Between 2016 and 2017.

Mater Sociomed 2018 Oct;30(3):189-192

Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: Cerebral arterial variations are commonly associated with cerebrovascular disease and should be considered during brain surgeries. Since some cerebrovascular diseases are seen in certain breeds, it seems that different distributions of cerebral arterial variations depend on race.

Aim: The aim of this study was to determine the random incidence of vascular anomalies of the circle of Willis in autopsy of the cadavers. Read More

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October 2018

Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis.

Crit Care 2018 Dec 4;22(1):327. Epub 2018 Dec 4.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

Background: Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation (CAR) may result in brain hypoperfusion and neuronal damage leading to SABD. Read More

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December 2018
1 Read

Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.

Curr Neurovasc Res 2018 Dec 4. Epub 2018 Dec 4.

Center of Cerebrovascular Disease, Department of Neurology, West China Hospital, Sichuan University, Chengdu. China.

Background And Purpose: Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of hemorrhagic transformation (HT) after acute ischemic stroke (AIS).

Methods: Patients within seven days after stroke onset were included between January 2016 and October 2017. The laboratory data were collected within 24 hours after admission. Read More

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December 2018

Differences in characteristics and outcomes after endovascular therapy: A single-center analysis of patients with vertebrobasilar occlusion due to underlying intracranial atherosclerosis disease and embolism.

Interv Neuroradiol 2018 Dec 4:1591019918811800. Epub 2018 Dec 4.

1 Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Therapeutic strategies and outcomes vary with stroke subtypes for patients with acute vertebrobasilar occlusion (VBAO). This study aimed to compare characteristics and outcomes of VBAO due to intracranial atherosclerotic disease (ICAD) and embolisms and identify baseline predictors of ICAD.

Methods: Patients with VBAO who received endovascular therapy (EVT) were retrospectively analyzed. Read More

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December 2018

The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AP, UK.

Research has suggested a number of beneficial effects arising from the consumption of dietary flavonoids, found in foods such as cocoa, apples, tea, citrus fruits and berries on cardiovascular risk factors such as high blood pressure and endothelial dysfunction. These effects are thought to have a significant impact upon both vascular and cerebrovascular health, ultimately with the potential to prevent cardiovascular and potentially neurodegenerative disease with a vascular component, for example vascular dementia. This review explores the current evidence for the effects of flavonoid supplementation on human endothelial function and both peripheral and cerebral blood flow (CBF). Read More

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December 2018

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Institute of Biomedical and Clinical Sciences (IBCS), College of Medicine and Health (CMH), St. Luke's Campus, University of Exeter, Exeter EX4 4QL, UK.

For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91 and was considered to be a peculiarity of professional phagocytic cells. Over the last decade, several more homologs have been identified and based on current research, the NOX family consists of NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1 and DUOX2 enzymes. NOXs are electron transporting membrane proteins that are responsible for reactive oxygen species (ROS) generation-primarily superoxide anion (O₂), although hydrogen peroxide (H₂O₂) can also be generated. Read More

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November 2018
1 Read

Primary Aldosteronism and Cerebrovascular Diseases.

Endocrinol Metab (Seoul) 2018 Dec;33(4):429-434

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease, myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemic attack. Moreover, PA is associated more closely with these conditions than is essential hypertension. Read More

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December 2018
1 Read

The Management of Acute Ischemic Strokes and the Prevalence of Large Vessel Occlusion in Left Ventricular Assist Device.

Cerebrovasc Dis 2018 Dec 4;46(5-6):213-217. Epub 2018 Dec 4.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio,

Background: Ischemic and hemorrhagic strokes are frequent complications among those with left ventricular assist device (LVAD). Scarce data exist regarding the prevalence of acute large vessel occlusion (LVO) and treatment of acute ischemic stroke (AIS) in this setting.

Methods: We reviewed prospectively collected data of LVAD patient registry from a single, tertiary center from October 2004 to November 2016. Read More

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December 2018
3 Reads

An autopsy case of progressive multifocal leukoencephalopathy after rituximab therapy for malignant lymphoma.

Neuropathology 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Kurume University School of Medicine, Kurume, Japan.

Progressive multifocal leukoencephalopathy (PML) is a rare fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus (JCV), which is named after the initials of the patient from whom the virus was first isolated. JCV is highly prevalent worldwide, infects humans in early childhood, and the infection persists throughout the course of life in latent form. The present paper deals with the second autopsy case report of rituximab-associated PML in Japan. Read More

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December 2018
2 Reads