3,096 results match your criteria Cerebrovascular Diseases[Journal]


Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy.

Cerebrovasc Dis 2019 Apr 10:1-8. Epub 2019 Apr 10.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA,

Background And Purpose: The role played by post-stroke inflammation after an ischemic event in limiting functional recovery remains unclear. One component of post-stroke inflammation is disruption of the blood-brain barrier (BBB). This study examines the relationship between post-stroke BBB disruption and functional outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499666DOI Listing
April 2019
1 Read

Successful Reperfusion with Endovascular Therapy Has Beneficial Effects on Long-Term Outcome Beyond 90 Days.

Cerebrovasc Dis 2019 Apr 9:1-8. Epub 2019 Apr 9.

Comprehensive Stroke Center, Kobe City Medical Center General Hospital, Kobe, Japan.

Background And Purpose: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hypothesized that successful reperfusion might be associated with long-term improvement beyond 90 days after endovascular therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499190DOI Listing
April 2019
2 Reads

Genotype-Phenotype Correlation in Long-Term Cohort of Japanese Patients with Moyamoya Disease.

Cerebrovasc Dis 2019 Apr 4:1-7. Epub 2019 Apr 4.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Background: Homozygosity of this p.R4810K founder variant of RNF213 moyamoya disease (MMD) susceptibility gene is known to influence the severity of the clinical disease phenotype at disease onset. However, the association between this genotype and long-term clinical manifestations has remained unclear. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/499699
Publisher Site
http://dx.doi.org/10.1159/000499699DOI Listing
April 2019
3 Reads

Comparison Study of ASCO and TOAST Classification System in Chinese Minor Stroke Patients.

Cerebrovasc Dis 2019 28;47(1-2):95-100. Epub 2019 Mar 28.

Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China,

Background: Precise subtype classification based on underlying pathophysiology is important to prevent recurrent attack in minor stroke patients. A newly developed Atherosclerosis, Small vessel disease, Cardiac source, Others (ASCO) phenotypic classification system aims to characterize patients using different grades of evidence for stroke subtypes. However, this system has not been specifically applied to minor stroke population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497478DOI Listing
March 2019
1 Read
3.754 Impact Factor

Air Pollution and Stroke: Is there Really a Significant Relationship.

Authors:
Marc Fatar

Cerebrovasc Dis 2019 28;47(1-2):101. Epub 2019 Mar 28.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499328DOI Listing

Serum Albumin Is Negatively Associated with Hemorrhagic Transformation in Acute Ischemic Stroke Patients.

Cerebrovasc Dis 2019 21;47(1-2):88-94. Epub 2019 Mar 21.

Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, Chengdu, China,

Background And Objective: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke (AIS). Serum albumin is known for its neuroprotective effects and is a marker of improved AIS patient outcomes. However, it is not known whether there is a relationship between serum albumin and HT. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/498855
Publisher Site
http://dx.doi.org/10.1159/000498855DOI Listing
March 2019
4 Reads
3.754 Impact Factor

A COACHS Nomogram to Predict the Probability of Three-Month Unfavorable Outcome after Acute Ischemic Stroke in Chinese Patients.

Cerebrovasc Dis 2019 21;47(1-2):80-87. Epub 2019 Mar 21.

Department of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Background: Accurate prognostication of unfavorable outcome made at the early onset of stroke is important to both the clinician and the patient management. This study was aimed to develop a nomogram based on the integration of parameters to predict the probability of 3-month unfavorable functional outcome in Chinese acute ischemic stroke patients.

Methods: We retrospectively collected patients who underwent acute ischemic stroke at Stroke Center of the Nanjing First Hospital (China) between May 2013 and May 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497243DOI Listing
March 2019
1 Read
3.754 Impact Factor

Editorial.

Cerebrovasc Dis 2019 21;47(1-2). Epub 2019 Mar 21.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499327DOI Listing

Serotonergic Regulation and Cognition after Stroke: The Role of Antidepressant Treatment and Genetic Variation.

Cerebrovasc Dis 2019 7;47(1-2):72-79. Epub 2019 Mar 7.

Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Aarhus, Denmark,

Introduction: Serotonin affects several brain functions including cognition. The serotonin transporter (SERT) regulates brain serotonin levels through reuptake into neurons. The gene encoding this transporter, the SERT gene, has several functional polymorphisms affecting the number of transporters and thereby the serotonin levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498911DOI Listing

Endovascular Thrombectomy in the Elderly: Do Radiological and Clinical Outcomes Differ from Those in Younger Patients? A Prospective Single-Center Experience.

Cerebrovasc Dis 2019 26;47(1-2):65-71. Epub 2019 Feb 26.

Department of Neurology, Stavanger University Hospital, Stavanger, Norway.

Objectives: Endovascular treatment (EVT) has emerged as the gold standard therapy for stroke due to large vessel occlusion (LVO). There is however limited evidence to suggest that similar efficacy can be expected in elderly patients. We aimed to assess the efficacy and safety of EVT in elderly patients (aged > 80), comparing outcomes to younger patients (aged < 80). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497315DOI Listing
February 2019
1 Read

Reduced Hypoxic Tissue and Cognitive Improvement after Revascularization Surgery for Chronic Cerebral Ischemia.

Cerebrovasc Dis 2019 15;47(1-2):57-64. Epub 2019 Feb 15.

Department of Neurosurgery, Iwate Medical University, Morioka, Japan,

Background: Hypoxic but viable neural tissue is seen on 1-(2-18F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (18F-FRP170) positron emission tomography (PET) in patients with chronic cerebral ischemia with a combination of misery perfusion and moderately reduced oxygen metabolism. Cognitive function sometimes improves after revascularization surgery in patients with chronic cerebral ischemia.

Objectives: We used brain perfusion single-photon emission computed tomography (SPECT) and 18F-FRP170 PET to determine whether hypoxic tissue was reduced following the restoration of cerebral perfusion after carotid endarterectomy (CEA) in patients with severe stenosis of the cervical internal carotid artery (ICA) and whether the reduction in hypoxic tissue was associated with cognitive improvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497244DOI Listing
February 2019

Renal Impairment Is Associated with Intracerebral Hemorrhage after Mechanical Thrombectomy in Vertebrobasilar Stroke.

Cerebrovasc Dis 2019 15;47(1-2):48-56. Epub 2019 Feb 15.

Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany,

Background And Purpose: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far.

Materials And Methods: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497070DOI Listing
February 2019
1 Read

Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.

Cerebrovasc Dis 2019 14;47(1-2):24-31. Epub 2019 Feb 14.

Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial.

Methods: Subjects in the SAMMPRIS trial were included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497245DOI Listing
February 2019
1 Read

Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients.

Cerebrovasc Dis 2019 14;47(1-2):32-39. Epub 2019 Feb 14.

Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea,

Background: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497069DOI Listing
February 2019
2 Reads

One-Year Risk of Recurrent Stroke and Death Associated with Vertebrobasilar Artery Stenosis and Occlusion in a Cohort of 10,515 Patients.

Cerebrovasc Dis 2019 14;47(1-2):40-47. Epub 2019 Feb 14.

College of Medicine, China Medical University, Taichung, Taiwan.

Background: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied.

Methods: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495418DOI Listing
February 2019
1 Read

Associations of High Intensities on Magnetization-Prepared Rapid Acquisition with Gradient Echo with Aortic Complicated Lesions in Ischemic Stroke Patients.

Cerebrovasc Dis 2019 14;47(1-2):15-23. Epub 2019 Feb 14.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Background: Aortic complicated lesions (ACLs) are key parameters for evaluating aortic embolic sources in embolic stroke, and are usually diagnosed using transesophageal echocardiography (TEE). However, alternative methods for diagnosing ACLs have not been well established. We investigated associations between high-intensity areas on T1-weighted imaging (T1WI) with magnetization-prepared rapid acquisition with gradient echo (MPRAGE) and ACLs on TEE among ischemic stroke patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497068DOI Listing
February 2019

Using the Region of Interest from Time-of-Flight Magnetic Resonance Angiography to Differentiate Between Intracranial Arterial Dissection and True Atherosclerotic Stenosis.

Cerebrovasc Dis 2019 6;47(1-2):8-14. Epub 2019 Feb 6.

Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea,

Background: Noncontrast three-dimensional time-of-flight magnetic resonance angiography (3D TOF MRA) is commonly used to examine intracranial arterial stenosis, although it can be difficult to identify the etiology of the stenosis. Our aim was to determine the effectiveness of 3D TOF MRA in differentiating an intracranial arterial dissection from atherosclerosis.

Methods: During 2015-2017, 356 patients had confirmed intracranial arterial stenosis based on high resolution-magnetic resonance imaging. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/496505
Publisher Site
http://dx.doi.org/10.1159/000496505DOI Listing
February 2019
16 Reads
3.754 Impact Factor

European Stroke Conference. 27th Conference, Athens, Greece, April 11-13, 2018.

Authors:

Cerebrovasc Dis 2018 28;45 Suppl 1:I-II. Epub 2018 May 28.

Click here for the free "http://misc.karger.com/websites/CED_2018_045_S1/index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490132DOI Listing

Risks of Acute Stroke Treatment in Patients with Cardiac Disease.

Cerebrovasc Dis 2018 18;46(5-6). Epub 2019 Jan 18.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496627DOI Listing
January 2019
1 Read

Returning to Unpaid Work after Stroke: The Psychosocial Outcomes in Stroke Cohort Study.

Cerebrovasc Dis 2019 17;47(1-2):1-7. Epub 2019 Jan 17.

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Background: While returning to paid work is a crucial marker of stroke recovery, little is known about the differences in unpaid work by sex following stroke. We aimed to determine the sex differences in participation in unpaid work 12 months after stroke.

Methods: Psychosocial outcomes in stroke were a prospective, multicentre observational study that recruited individuals, 18-64 years, within 28 days of stroke from New South Wales, Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496399DOI Listing
January 2019
2 Reads

The Relationship between Blood Pressure Variability, Recanalization Degree, and Clinical Outcome in Large Vessel Occlusive Stroke after an Intra-Arterial Thrombectomy.

Cerebrovasc Dis 2018 15;46(5-6):279-286. Epub 2019 Jan 15.

Department of Neurology, Seoul National University College of Medicine, Seoul National University Bun-Dang Hospital, Seongnam, Republic of Korea,

Background: Blood pressure variability (BPV) is associated with target organ damage progression and increased cardiovascular events, including stroke. The aim of this study was to evaluate the associations between short-term BPV during acute periods and recanalization degree, early neurological deterioration (END) occurrence, and functional outcomes in acute ischemic stroke patients who had undergone intra-arterial thrombectomy (IAT).

Methods: We retrospectively analyzed 303 patients with large vessel occlusive stroke who underwent IAT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495300DOI Listing
January 2019
3 Reads

Intra-Plaque Vessels on Contrast-Enhanced Ultrasound Sonography Predict Carotid Plaque Histology.

Cerebrovasc Dis 2018 15;46(5-6):265-269. Epub 2019 Jan 15.

Department of Neurosurgery, Fukuoka University, Fukuoka, Japan.

Background And Purpose: Although the echogenicity of carotid plaques on carotid enhanced ultrasound (CEUS) was reported to correlate with the historological density of intra-plaque neovessels, it is unclear whether the intra-plaque vessel size is associated with carotid plaque vulnerability. We evaluated the relationship of size of intra-plaque vessels on CEUS with carotid plaque histology.

Methods: We prospectively registered patients with carotid stenosis who were hospitalized to receive carotid endarterectomy between 2012 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495299DOI Listing
January 2019
2 Reads

Thrombus Enhancement Is a Predictor of Clinical Outcome in Acute Ischemic Stroke after Mechanical Thrombectomy.

Cerebrovasc Dis 2018 15;46(5-6):270-278. Epub 2019 Jan 15.

Uniklinik Köln, Institut für Diagnostische und Interventionelle Radiologie, Cologne, Germany.

Background: Ex vivo computed tomography (CT) studies of artificial blood thrombi showed that contrast enhancement (CE) is determined by fibrin-content, while unenhanced density is associated with red blood cells. Thus, the present study investigates patient outcome in association with combined thrombus density measures in native and contrast-enhanced CT (CECT) of acute ischemic stroke patients.

Methods: This retrospective study includes 137 patients with M1 occlusions treated by mechanical thrombectomy (MT) between 2010 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495419DOI Listing
January 2019
1 Read

Adenosine Deaminase Two and Immunoglobulin M Accurately Differentiate Adult Sneddon's Syndrome of Unknown Cause.

Cerebrovasc Dis 2018 15;46(5-6):257-264. Epub 2019 Jan 15.

Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background: The association that exists between livedo reticularis (LR) and stroke is known as Sneddon's syndrome (SnS). The disorder is classified as primary SnS (PSnS), if the cause remains unknown and secondary SnS. The condition is rare and it occurs mainly sporadically. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495794DOI Listing
January 2019
6 Reads

Cholesterol Crystals in Embolic Debris are Associated with Postoperative Cerebral Embolism after Carotid Artery Stenting.

Cerebrovasc Dis 2018 2;46(5-6):242-248. Epub 2019 Jan 2.

Department of Neurosurgery, Stroke Center, Ise Red Cross Hospital, Ise City, Japan.

Object: We investigated possible associations among the presence of cholesterol crystals in embolic debris, the proportions of debris components, and postoperative cerebral embolism in patients undergoing carotid artery stenting (CAS).

Methods: Sixty-seven consecutive procedures were performed for internal carotid artery stenosis with CAS at our hospital between November 2015 and February 2018. Procedures for emergency CAS for stroke in evolution or crescendo transient ischemic attack were excluded (n = 12). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495795DOI Listing
January 2019
4 Reads

Baseline Characteristics and Readmissions after Cerebral Venous Sinus Thrombosis in a Nationally Representative Database.

Cerebrovasc Dis 2018 2;46(5-6):249-256. Epub 2019 Jan 2.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA,

Background: There are limited epidemiologic data on cerebral venous sinus thrombosis (CVST). We aim to summarize baseline characteristics and outcomes using a large nationally representative administrative database.

Methods: Using the 2013 Nationwide Readmissions Database, we used validated International Classification of Disease, Ninth Revision codes to identify baseline characteristics of patients admitted with CVST. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495420DOI Listing
January 2019
1 Read

Left-Sided Atrial Septal Pouch as a Risk Factor of Cryptogenic Stroke: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2018 5;46(5-6):223-229. Epub 2018 Dec 5.

HEART, Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.

Background: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach.

Methods: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495573DOI Listing
December 2018
3 Reads

A Systematic Review and Meta-Analysis of Molecular Biomarkers Associated with Early Neurological Deterioration Following Acute Stroke.

Cerebrovasc Dis 2018 5;46(5-6):230-241. Epub 2018 Dec 5.

NIHR Newcastle Biomedical Research Centre and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom,

Background: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495572
Publisher Site
http://dx.doi.org/10.1159/000495572DOI Listing
December 2018
15 Reads

Cervical Artery Dissection in Patients of African Ancestry.

Cerebrovasc Dis 2018 5;46(5-6):218-222. Epub 2018 Dec 5.

Departments of Neurology, University of Virginia Health System, Charlottesville, Virginia, USA,

Background And Purpose: The majority of published data in cervical artery dissection (CeAD), a common cause of stroke in young adults, derive from populations of European ancestry (EA), including a recent genome-wide study identifying an association with the rs9349379 polymorphism of the PHACTR1 gene. Little is known about CeAD in individuals of African ancestry (AA) despite robust epidemiological data showing increased risk of stroke at younger ages. We hypothesize that AA patients with CeAD have different epidemiology and clinical profiles compared to those of EA, and a different genetic architecture related to rs9349379 of the PHACTR1 gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494704DOI Listing
December 2018
4 Reads

The Management of Acute Ischemic Strokes and the Prevalence of Large Vessel Occlusion in Left Ventricular Assist Device.

Cerebrovasc Dis 2018 4;46(5-6):213-217. Epub 2018 Dec 4.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA,

Background: Ischemic and hemorrhagic strokes are frequent complications among those with left ventricular assist device (LVAD). Scarce data exist regarding the prevalence of acute large vessel occlusion (LVO) and treatment of acute ischemic stroke (AIS) in this setting.

Methods: We reviewed prospectively collected data of LVAD patient registry from a single, tertiary center from October 2004 to November 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495080DOI Listing
December 2018
10 Reads

Challenge of Attaining Flow Arrest in Anterior Circulation Tandem Occlusions in Large Vessel Ischemic Stroke: Wedged SAVE Technique.

Cerebrovasc Dis 2018 12;46(5-6):211-212. Epub 2018 Nov 12.

Department of Neuroradiology, University Hospital of Aachen, Aachen, Germany.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494703
Publisher Site
http://dx.doi.org/10.1159/000494703DOI Listing
November 2018
13 Reads

The Impact of Cerebral Atherosclerosis According to Location on Prognosis after Coronary Artery Bypass Grafting.

Cerebrovasc Dis 2018 8;46(5-6):200-209. Epub 2018 Nov 8.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea,

Background: In the previous prospective observational study, we found that cerebral atherosclerosis is an independent predictor of acute stroke after coronary artery bypass grafting (CABG). However, it is unknown whether intracranial cerebral atherosclerosis (ICAS) is important as much as extracranial cerebral atherosclerosis (ECAS) in estimating the risk of post-CABG adverse events. Extending the previous study, we aimed to investigate the immediate and long-term prognostic value of the location of cerebral atherosclerosis in CABG patients. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494502
Publisher Site
http://dx.doi.org/10.1159/000494502DOI Listing
November 2018
21 Reads

Ten-Year Evaluation of the TOYOTA Prehospital Stroke Scale for Tissue Plasminogen Activator Intravenous Therapy in the Real World.

Cerebrovasc Dis 2018 1;46(3-4):184-192. Epub 2018 Nov 1.

Department of Neurology, TOYOTA Memorial Hospital, Toyota, Japan.

Background: Emergency medical services are an important part of acute stroke management. We devised a prehospital stroke scale, the TOYOTA prehospital stroke scale for tissue plasminogen activator (t-PA) intravenous therapy (TOPSPIN) for triaging patients with ischemic stroke and especial indications for intravenous t-PA therapy in December 2006; this scale comprises 5 items including consciousness, atrial fibrillation, language disorder, disturbance of the upper extremities, and disturbance of the lower extremities. The aim of this study was to analyze the results of 10 years of TOPSPIN implementation and to distinguish ischemic stroke from hemorrhagic stroke in the real world. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494364DOI Listing
November 2018
5 Reads

Safety of Endovascular Thrombectomy for Acute Ischaemic Stroke in Anticoagulated Patients Ineligible for Intravenous Thrombolysis.

Cerebrovasc Dis 2018 1;46(5-6):193-199. Epub 2018 Nov 1.

Department of Radiology, Neurointervention Service, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia,

Background/aim: Endovascular thrombectomy may be performed in anticoagulated patients taking vitamin-K antagonists (VKA) or direct-acting oral anticoagulants (DOAC) in whom the use of intravenous tissue plasminogen activator (tPA) is contraindicated. We aimed to investigate the efficacy and safety of mechanical thrombectomy specifically in anticoagulated patients ineligible for thrombolysis.

Methods: We performed a retrospective analysis of a prospectively collected database of consecutive ischaemic stroke patients undergoing mechanical thrombectomy from January 2008 to June 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000493801DOI Listing
November 2018
13 Reads

Transcranial Magnetic Stimulation as an Intervention Tool to Recover from Language, Swallowing and Attentional Deficits after Stroke: A Systematic Review.

Cerebrovasc Dis 2018 19;46(3-4):178-185. Epub 2018 Oct 19.

Coimbra Institute for Biomedical Imaging and Translational Research/Institute of Nuclear Sciences Applied to Health (CIBIT/ICNAS), University of Coimbra, Coimbra,

Background: Following a stroke event, patients often are severely affected by disabilities that hinder their quality-of-life. There are currently several rehabilitative options and strategies, and it is crucial to find the most effective interventions. The applicability of transcranial magnetic stimulation (TMS) to the recovery of nonmotor functions such as communication skills, swallowing ability and spatial attention after stroke remains important clinical questions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494213DOI Listing
October 2018
5 Reads

Endovascular Clot Retrieval by Hub-and-Spoke Service Delivery is Feasible Compared with Direct-to-Mothership.

Cerebrovasc Dis 2018 9;46(3-4):172-177. Epub 2018 Oct 9.

Department of Radiology, Neurointervention Service, Royal Melbourne Hospital, Melbourne, Victoria,

Background: Endovascular clot retrieval (ECR) improves outcomes for acute ischaemic stroke with large artery occlusion. However, the provision of ECR requires resource-intensive comprehensive stroke centres (CSC), which are impractical to establish in regional hospitals. An alternative is a "hub-and-spoke" model, whereby ischaemic strokes are triaged at the regional primary centres and where eligible, transferred to a CSC. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/490421
Publisher Site
http://dx.doi.org/10.1159/000490421DOI Listing
October 2018
4 Reads

ACTA2 Cerebral Arteriopathy: Not Just a Puff of Smoke.

Cerebrovasc Dis 2018 9;46(3-4):161-171. Epub 2018 Oct 9.

Carilion Clinic, Section of Neurosurgery, Roanoke, Virginia, USA.

Background: Missense mutations in the gene that codes for smooth muscle actin, ACTA2, cause diffuse smooth muscle dysfunction and a distinct cerebral arteriopathy collectively known as multisystemic smooth muscle dysfunction syndrome (MSMDS). Until recently, ACTA2 cerebral arteriopathy was considered to be a variant of moyamoya disease. However, recent basic science and clinical data have demonstrated that the cerebral arteriopathy caused by mutant ACTA2 exhibits genetic loci, histopathology, neurological sequelae, and radiographic findings unique from moyamoya disease. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/493863
Publisher Site
http://dx.doi.org/10.1159/000493863DOI Listing
October 2018
14 Reads

Predicting Dysphagia with National Institute of Health Stroke Scale: Distinction between Infra- and Supratentorial Region is Essential.

Cerebrovasc Dis 2018 25;46(3-4):152-160. Epub 2018 Sep 25.

Background: For the early detection of post-stroke dysphagia (PSD), valid screening parameters are crucial as part of a step-wise diagnostic procedure. This study examines the role of the National Institute of Health Stroke Scale (NIH-SS) as a potential low-threshold screening parameter.

Methods: During a ten-year period, 687 newly admitted patients at University Hospital Muenster were included in a retrospective analysis, if they had ischemic or haemorrhagic stroke confirmed by neuroimaging and had received NIH-SS scoring and endoscopic swallowing evaluation upon admission. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/493371
Publisher Site
http://dx.doi.org/10.1159/000493371DOI Listing
September 2018
15 Reads

Insulin Resistance Index from Oral Glucose Tolerance Test Predicts Ischemic Stroke Outcomes in Non-Diabetic Patients with Different Estimated Glomerular Filtration Rate Strata.

Cerebrovasc Dis 2018 20;46(3-4):142-151. Epub 2018 Sep 20.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Insulin resistance is associated with cardiovascular morbidity and mortality in the general population. However, the relationship between insulin resistance and health outcomes is controversial in patients with impaired renal function. Our study aimed to investigate the association between insulin resistance and prognosis in a cohort of non-diabetic stroke patients with different estimated glomerular filtration rate (eGFR) strata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492125DOI Listing
September 2018
4 Reads
3.754 Impact Factor

Mechanical Thrombectomy in Acute Stroke Due to Carotid Occlusion: A Series of 153 Consecutive Patients.

Cerebrovasc Dis 2018 13;46(3-4):132-141. Epub 2018 Sep 13.

Section of Interventional Neuroradiology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.

Background: Strokes due to carotid artery occlusion (CAO) are associated with bad clinical prognosis and poor response to intravenous thrombolysis. Several studies in the past have shown the benefits of mechanical thrombectomy (MT) and compared bridging therapy (BT) and primary MT (PMT) in large vessel occlusions, but only a few studies have focused on the specific population of CAO and their response to endovascular treatment.

Methods: Retrospective review of patients treated at our center between January 2010 and June 2017 that (1) presented with acute ischemic stroke caused by CAO in the first 4. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492866
Publisher Site
http://dx.doi.org/10.1159/000492866DOI Listing
September 2018
12 Reads

Patterns and Outcomes of the Top of the Basilar Artery Syndrome: The Role of the Posterior Communicating Artery.

Cerebrovasc Dis 2018 10;46(3-4):108-117. Epub 2018 Sep 10.

Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Republic of

Background: Clinical syndromes secondary to infarcts in the distal basilar artery (BA) area have been described as "top of the basilar" (TOB) syndrome. However, in the era of advanced imaging technology, it has been realized that the clinical and imaging features are quite diverse in patients with distal BA occlusion. The aim of the present study was to investigate the patterns and clinical outcomes of TOB assessed with modern images and categorize TOBs accordingly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492059DOI Listing
September 2018
2 Reads

Hypercoagulation on Thromboelastography Predicts Early Neurological Deterioration in Patients with Acute Ischemic Stroke.

Cerebrovasc Dis 2018 10;46(3-4):125-131. Epub 2018 Sep 10.

Department of Neurology, Dongguan People's Hospital, Dongguan, China.

Background: Thromboelastography (TEG) provides an integrated measurement of blood coagulation function and has been reported to be a useful tool for predicting clinical outcomes in patients with cardiovascular diseases. We aimed to investigate the application of TEG on admission for predicting early neurological deterioration (END) in patients with acute ischemic stroke and its potential correlation with the evolution of ischemic lesions.

Methods: Among patients consecutively admitted between January 1, 2016, and September 31, 2017, those presenting with mild and moderate acute ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score ≤14) within 24 h of stroke onset were identified and included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492729DOI Listing
September 2018
19 Reads

Impact of Dysphagia Assessment and Management on Risk of Stroke-Associated Pneumonia: A Systematic Review.

Cerebrovasc Dis 2018 10;46(3-4):99-107. Epub 2018 Sep 10.

Greater Manchester Comprehensive Stroke Centre, Manchester Academic Health Science Centre, Salford Royal Foundation Trust, Salford, United Kingdom.

Background: Patients with dysphagia are at an increased risk of stroke-associated pneumonia. There is wide variation in the way patients are screened and assessed during the acute phase. The aim of this review was to identify the methods of assessment and management in acute stroke that influence the risk of stroke-associated pneumonia. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492730
Publisher Site
http://dx.doi.org/10.1159/000492730DOI Listing
September 2018
9 Reads

Early Achievement of Blood Pressure Lowering and Hematoma Growth in Acute Intracerebral Hemorrhage: Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement-Intracerebral Hemorrhage Study.

Cerebrovasc Dis 2018 10;46(3-4):118-124. Epub 2018 Sep 10.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Background: Previous studies have revealed that hematoma growth mainly occurs during the first 6 h after the onset of spontaneous intracerebral hemorrhage (ICH). Early lowering of blood pressure (BP) may be beneficial for preventing hematoma growth. However, relationships between timing of BP lowering and hematoma growth in ICH remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492728DOI Listing
September 2018
2 Reads

Onset to Reperfusion Time Was Not Important in Mechanical Thrombectomy for Elderly Patients: A Retrospective Multicenter Study in Tama Area, Tokyo.

Cerebrovasc Dis 2018 6;46(1-2):89-96. Epub 2018 Sep 6.

Department of Stroke and Cerebrovascular Medicine, Kyorin University, Mitaka, Japan.

Background: Mechanical thrombectomy (MT) has become the standard of care for acute ischemic stroke with large vessel occlusion; however, evidence remains insufficient for MT for elderly patients, especially with respect to factors affecting their outcomes.

Methods: This study was a retrospective analysis of a multicenter registry of MT, called Tama Registry of Acute Endovascular Thrombectomy. Patients were divided by their age into 2 groups: Nonelderly (NE; < 80) and elderly (E; ≥80). Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492867
Publisher Site
http://dx.doi.org/10.1159/000492867DOI Listing
September 2018
8 Reads

Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies.

Cerebrovasc Dis 2018 5;46(1-2):82-88. Epub 2018 Sep 5.

Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.

Background And Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke.

Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214602PMC
September 2018
6 Reads

Peak Troponin I Levels Are Associated with Functional Outcome in Intracerebral Hemorrhage.

Cerebrovasc Dis 2018 23;46(1-2):72-81. Epub 2018 Aug 23.

Department of Neurology, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany.

Background: Troponin I is a widely used and reliable marker of myocardial damage and its levels are routinely measured in acute stroke care. So far, the influence of troponin I elevations during hospital stay on functional outcome in patients with atraumatic intracerebral hemorrhage (ICH) is unknown.

Methods: Observational single-center study including conservatively treated ICH patients over a 9-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492395DOI Listing
August 2018
20 Reads