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    101 results match your criteria Cerebrospinal Fluid Research [Journal]

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    Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain.
    Cerebrospinal Fluid Res 2010 Nov 5;7:20. Epub 2010 Nov 5.
    University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
    Background: The water channel protein aquaporin-4 (AQP4) is reported to be of possible major importance for accessory cerebrospinal fluid (CSF) circulation pathways. We hypothesized that changes in AQP4 expression in specific brain regions correspond to the severity and duration of hydrocephalus.

    Methods: Hydrocephalus was induced in adult rats (~8 weeks) by intracisternal kaolin injection and evaluated after two days, one week and two weeks. Read More

    Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus.
    Cerebrospinal Fluid Res 2010 Nov 5;7:19. Epub 2010 Nov 5.
    Division of Pediatric Neurosurgery, University of Cincinnati, Cincinnati Children's Hospital Medical Center MLC 2016, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
    Background: Diffusion tensor imaging (DTI) is a non-invasive MRI technique that has been used to quantify CNS abnormalities in various pathologic conditions. This study was designed to quantify the anisotropic diffusion properties in the brain of neonatal rats with hydrocephalus (HCP) and to investigate association between DTI measurements and cytopathology.

    Methods: DTI data were acquired between postnatal day 7 (P7) and P12 in 12 rats with HCP induced at P2 and in 15 age-matched controls. Read More

    Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme: a prospective cohort study.
    Cerebrospinal Fluid Res 2010 Oct 31;7:18. Epub 2010 Oct 31.
    Department of Neurosurgery, Noto General Hospital, Nanao, 926-8610, Japan.
    Background: Idiopathic normal pressure hydrocephalus (iNPH) is a treatable neurological syndrome in the elderly. Although the magnetic resonance imaging (MRI) findings of tight high-convexity and medial subarachnoid spaces and the ventriculo-peritoneal (VP) shunt with programmable valve are reportedly useful for diagnosis and treatment, respectively, their clinical significance remains to be validated. We conducted a multicenter prospective study (Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement: SINPHONI) to evaluate the utility of the MRI-based diagnosis for determining the 1-year outcome after VP shunt with the Codman-Hakim programmable valve. Read More

    Congenital myelomeningocele - do we have to change our management?
    Cerebrospinal Fluid Res 2010 Oct 14;7:17. Epub 2010 Oct 14.
    Department of Pediatric Surgery, University Hospital Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany.
    Background: Eagerly awaiting the results of the Management of Myelomeningocele Study (MOMS) and with an increasing interest in setting up intrauterine myelomeningocele repair (IUMR), the optimal management of patients suffering from congenital myelomeningocele (MMC) has become a matter of debate again. We performed a cross-sectional study at our referral-center for MMC to determine the outcome for our expectantly managed patients.

    Materials And Methods: A computed chart review at our institution revealed 70 patients suffering from MMC. Read More

    Development of the lateral ventricular choroid plexus in a marsupial, Monodelphis domestica.
    Cerebrospinal Fluid Res 2010 Oct 5;7:16. Epub 2010 Oct 5.
    Department of Pharmacology, the University of Melbourne, Melbourne, 3039, Australia.
    Background: Choroid plexus epithelial cells are the site of blood/cerebrospinal fluid (CSF) barrier and regulate molecular transfer between the two compartments. Their mitotic activity in the adult is low. During development, the pattern of growth and timing of acquisition of functional properties of plexus epithelium are not known. Read More

    Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus.
    Cerebrospinal Fluid Res 2010 Sep 22;7:15. Epub 2010 Sep 22.
    Kids Neurosurgical Research Unit, Institute of Neuroscience and Muscle Research, Kids Research Institute, Children's Hospital at Westmead, Hawkesbury Rd, Westmead NSW 2145, Australia.
    The discovery of a family of membrane water channel proteins called aquaporins, and the finding that aquaporin 1 was located in the choroid plexus, has prompted interest in the role of aquaporins in cerebrospinal fluid (CSF) production and consequently hydrocephalus. While the role of aquaporin 1 in choroidal CSF production has been demonstrated, the relevance of aquaporin 1 to the pathophysiology of hydrocephalus remains debated. This has been further hampered by the lack of a non-toxic specific pharmacological blocking agent for aquaporin 1. Read More

    Choroid plexus failure in the Kearns-Sayre syndrome.
    Cerebrospinal Fluid Res 2010 Aug 23;7:14. Epub 2010 Aug 23.
    Department of Neurosurgery, Alpert Medical School at Brown University, Providence, RI, 02903 USA.
    The Kearns-Sayre syndrome is a mitochondrial disorder (generally due to mitochondrial DNA deletions) that causes ophthalmoplegia, retinopathy, ataxia and brain abnormalities such as leukoencephalopathy. In this syndrome, the choroid plexus epithelial cells, unlike brain cells, are greatly enlarged and granular, consistent with their inability to adequately transport folate from blood into cerebrospinal fluid (CSF), and homovanillic acid (a dopamine metabolite) from CSF into blood. This inability to transport folates from blood into CSF (and brain) adequately, causes cerebral folate deficiency that can be partially reversed by very high doses of reduced folates. Read More

    Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain.
    Cerebrospinal Fluid Res 2010 Aug 13;7:13. Epub 2010 Aug 13.
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
    Background: Adult rat hypothalamo-pituitary axis and choroid plexus are rich in basic fibroblast growth factor (FGF2) which likely has a role in fluid homeostasis. Towards this end, we characterized the distribution and modulation of FGF2 in the human and rat central nervous system. To ascertain a functional link between arginine vasopressin (AVP) and FGF2, a rat model of chronic dehydration was used to test the hypothesis that FGF2 expression, like that of AVP, is altered by perturbed fluid balance. Read More

    Detection of viral antigen, IgM and IgG antibodies in cerebrospinal fluid of Chikungunya patients with neurological complications.
    Cerebrospinal Fluid Res 2010 Aug 13;7:12. Epub 2010 Aug 13.
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2, Bajaj Nagar, Nagpur 440010, India.
    Background: During Chikungunya virus (CHIKV) epidemic in Nagpur, India, we identified some suspected Chikungunya patients with neurological complications. Early and cost-effective diagnosis of these patients remains problematic despite many new advanced diagnostic methods. A reliable diagnostic test, which could be performed in any standard pathology laboratory, would help to obtain definitive early diagnosis of CHIKV patients with neurological complications. Read More

    Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier.
    Cerebrospinal Fluid Res 2010 Aug 12;7:11. Epub 2010 Aug 12.
    Ruprecht-Karls University, Department of Pharmaceutical Technology, 69120 Heidelberg, Germany.
    Background: Two rodent choroid plexus (CP) epithelial cell lines, Z310 and TR-CSFB, were compared with primary rat CP epithelial cells and intact CP tissue with respect to transport protein expression, function and tight junction (TJ) formation.

    Methods: For expression profiles of transporters and TJ proteins, qPCR and western blot analysis were used. Uptake assays were performed to study the functional activity of transporters and TJ formation was measured by trans-epithelial electrical resistance (TEER) and visualized by electron microscopy. Read More

    Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid.
    Cerebrospinal Fluid Res 2010 Jul 30;7:10. Epub 2010 Jul 30.
    Department of Neurology, Akershus University Hospital, Norway.
    Background: Alzheimer's disease (AD) and cerebrovascular disease (CVD) including chronic small vessel disease of the brain (SVD) are the most frequent causes of dementia. AD is associated with metabolism of amyloid precursor protein (APP) and low levels of amyloid-beta peptide (Abeta) X-42 in the cerebrospinal fluid (CSF). CVD and SVD are established risk factors for AD, brain white matter lesions (WML) are established surrogate markers for SVD and are also associated with reduced CSF AbetaX-42. Read More

    The function and structure of the cerebrospinal fluid outflow system.
    Cerebrospinal Fluid Res 2010 Jun 21;7. Epub 2010 Jun 21.
    14205 W Via Tercero, Sun City West, AZ 85375, USA.
    This review traces the development of our understanding of the anatomy and physiological properties of the two systems responsible for the drainage of cerebrospinal fluid (CSF) into the systemic circulation. The roles of the cranial and spinal arachnoid villi (AV) and the lymphatic outflow systems are evaluated as to the dominance of one over the other in various species and degree of animal maturation. The functional capabilities of the total CSF drainage system are presented, with evidence that the duality of the system is supported by the changes in fluid outflow dynamics in human and sub-human primates in hydrocephalus. Read More

    Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults.
    Cerebrospinal Fluid Res 2010 Jun 10;7. Epub 2010 Jun 10.
    Institute of Medicine, University of Bergen, 5021 Bergen, Norway.
    Background: Arachnoid cyst (AC) fluid has not previously been compared with cerebrospinal fluid (CSF) from the same patient. ACs are commonly referred to as containing "CSF-like fluid". The objective of this study was to characterize AC fluid by clinical chemistry and to compare AC fluid to CSF drawn from the same patient. Read More

    Minocycline inhibits glial proliferation in the H-Tx rat model of congenital hydrocephalus.
    Cerebrospinal Fluid Res 2010 May 27;7. Epub 2010 May 27.
    Department of Biology, Central Michigan University, Mt, Pleasant, MI 48859, USA.
    Background: Reactive astrocytosis and microgliosis are important features of the pathophysiology of hydrocephalus, and persistent glial "scars" that form could exacerbate neuroinflammation, impair cerebral perfusion, impede neuronal regeneration, and alter biomechanical properties. The purpose of this study was to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, to reduce gliosis in the H-Tx rat model of congenital hydrocephalus.

    Methods: Minocycline (45 mg/kg/day i. Read More

    Cerebrospinal fluid pulse pressure amplitude during lumbar infusion in idiopathic normal pressure hydrocephalus can predict response to shunting.
    Cerebrospinal Fluid Res 2010 Feb 12;7. Epub 2010 Feb 12.
    Department of Neurosurgery, Rikshospitalet University Hospital, Oslo, Norway.
    Background: We have previously seen that idiopathic normal pressure hydrocephalus (iNPH) patients having elevated intracranial pressure (ICP) pulse amplitude consistently respond to shunt surgery. In this study we explored how the cerebrospinal fluid pressure (CSFP) pulse amplitude determined during lumbar infusion testing, correlates with ICP pulse amplitude determined during over-night ICP monitoring and with response to shunt surgery. Our goal was to establish a more reliable screening procedure for selecting iNPH patients for shunt surgery using lumbar intrathecal infusion. Read More

    Cerebrospinal fluid sodium rhythms.
    Cerebrospinal Fluid Res 2010 Jan 20;7. Epub 2010 Jan 20.
    Huntington Medical Research Institutes, Pasadena, CA 91101, USA.
    Background: Cerebrospinal fluid (CSF) sodium levels have been reported to rise during episodic migraine. Since migraine frequently starts in early morning or late afternoon, we hypothesized that natural sodium chronobiology may predispose susceptible persons when extracellular CSF sodium increases. Since no mammalian brain sodium rhythms are known, we designed a study of healthy humans to test if cation rhythms exist in CSF. Read More

    Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts.
    Cerebrospinal Fluid Res 2010 Feb 26;7. Epub 2010 Feb 26.
    Centre for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
    Background: Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the temporal fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Read More

    Elevated CSF outflow resistance associated with impaired lymphatic CSF absorption in a rat model of kaolin-induced communicating hydrocephalus.
    Cerebrospinal Fluid Res 2010 Feb 10;7(1). Epub 2010 Feb 10.
    Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
    Background: We recently reported a lymphatic cerebrospinal fluid (CSF) absorption deficit in a kaolin model of communicating hydrocephalus in rats with ventricular expansion correlating negatively with the magnitude of the impediment to lymphatic function. However, it is possible that CSF drainage was not significantly altered if absorption at other sites compensated for the lymphatic defect. The purpose of this study was to investigate the impact of the lymphatic absorption deficit on global CSF absorption (CSF outflow resistance). Read More

    The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review.
    Cerebrospinal Fluid Res 2010 Jan 6;7. Epub 2010 Jan 6.
    Department of Anatomy, (109) UMC St Radboud, Nijmegen, the Netherlands.
    The cerebrospinal fluid (CSF) system provides nutrients to and removes waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these vary between locations, suggesting they are important for the changes in brain activity that underlie different brain states, and induce different sensory input and behavioral output relationships. Read More

    Expression and functional activity of nucleoside transporters in human choroid plexus.
    Cerebrospinal Fluid Res 2010 Jan 11;7. Epub 2010 Jan 11.
    Department of Physiology, Faculty of Medicine, Kuwait University, P O Box 24923, Kuwait.
    Background: Human equilibrative nucleoside transporters (hENTs) 1-3 and human concentrative nucleoside transporters (hCNTs) 1-3 in the human choroid plexus (hCP) play a role in the homeostasis of adenosine and other naturally occurring nucleosides in the brain; in addition, hENT1, hENT2 and hCNT3 mediate membrane transport of nucleoside reverse transcriptase inhibitors that could be used to treat HIV infection, 3'-azido-3'-deoxythymidine, 2'3'-dideoxycytidine and 2'3'-dideoxyinosine. This study aimed to explore the expression levels and functional activities of hENTs 1-3 and hCNTs 1-3 in human choroid plexus.

    Methods: Freshly-isolated pieces of lateral ventricle hCP, removed for various clinical reasons during neurosurgery, were obtained under Local Ethics Committee approval. Read More

    The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis.
    Cerebrospinal Fluid Res 2009 Dec 31;6:17. Epub 2009 Dec 31.
    Ecole Polytechnique Fédérale de Lausanne, Integrative Bioscience Institute, Laboratory of Hemodynamics and Cardiovascular Technology, Lausanne, Switzerland.
    Background: The influence of coughing, on the biomechanical environment in the spinal subarachnoid space (SAS) in the presence of a cerebrospinal fluid flow stenosis, is thought to be an important etiological factor in craniospinal disorders, including syringomyelia (SM), Chiari I malformation, and hydrocephalus. The aim of this study was to investigate SAS and syrinx pressures during simulated coughing using in vitro models and to provide information for the understanding of the craniospinal fluid system dynamics to help develop better computational models.

    Methods: Four in vitro models were constructed to be simplified representations of: 1) non-communicating SM with spinal SAS stenosis; 2) non-communicating SM due to spinal SAS stenosis with a distensible spinal column; 3) non-communicating SM post surgical removal of a spinal SAS stenosis; and 4) a spinal SAS stenosis due to spinal trauma. Read More

    Intraventricular infusion of hyperosmolar dextran induces hydrocephalus: a novel animal model of hydrocephalus.
    Cerebrospinal Fluid Res 2009 Dec 11;6:16. Epub 2009 Dec 11.
    Department of Neurosurgery, Upstate Medical University, Syracuse, NY 13210, USA.
    Background: Popular circulation theory of hydrocephalus assumes that the brain is impermeable to cerebrospinal fluid (CSF), and is therefore incapable of absorbing the CSF accumulating within the ventricles. However, the brain parenchyma is permeable to water due to the presence of specific ion channels as well as aquaporin channels. Thus, the movement of water into and out of the ventricles may be determined by the osmotic load of the CSF. Read More

    Activation of adenosine A2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells.
    Cerebrospinal Fluid Res 2009 Nov 18;6:15. Epub 2009 Nov 18.
    Departments of Neurosurgery & Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520-8082, USA.
    Background: Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system. While ciliary beat frequency in airway epithelia has been extensively studied, fewer reports have looked at the mechanisms involved in regulating ciliary beat frequency in ependyma. Read More

    More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure.
    Cerebrospinal Fluid Res 2009 Nov 16;6:14. Epub 2009 Nov 16.
    Department of Psychiatry, PC Sint-Amandus, Reigerlostraat 10, 8730 Beernem, Belgium.
    In a recent article, elevated cerebrospinal fluid pressure (CSFP) consistent with very early normal pressure hydrocephalus (NPH), was found in a small subset of Alzheimer's disease (AD) patients (possible AD-NPH hybrids) enrolled in a clinical trial for chronic low-flow cerebrospinal fluid drainage. Also in the same study, was another interesting finding that merits further discussion: a substantial proportion of AD patients had very low CSFP. Based on the characteristics of these subjects, we hypothesize that more advanced AD may be associated with a decrease in CSFP. Read More

    Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence setting.
    Cerebrospinal Fluid Res 2009 Nov 2;6:13. Epub 2009 Nov 2.
    Lung Infection and Immunity Unit, Division of Pulmonology & UCT Lung Institute, Department of Medicine, University of Cape Town, South Africa.
    Background: In Africa, tuberculous meningitis (TBM) is an important opportunistic infection in HIV-positive patients. Current diagnostic tools for TBM perform sub-optimally. In particular, the rapid diagnosis of TBM is challenging because smear microscopy has a low yield and PCR is not widely available in resource-poor settings. Read More

    Development of a theoretical framework for analyzing cerebrospinal fluid dynamics.
    Cerebrospinal Fluid Res 2009 Sep 22;6:12. Epub 2009 Sep 22.
    Mechanical, Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
    Background: To date hydrocephalus researchers acknowledge the need for rigorous but utilitarian fluid mechanics understanding and methodologies in studying normal and hydrocephalic intracranial dynamics. Pressure volume models and electric circuit analogs introduced pressure into volume conservation; but control volume analysis enforces independent conditions on pressure and volume. Previously, utilization of clinical measurements has been limited to understanding of the relative amplitude and timing of flow, volume and pressure waveforms; qualitative approaches without a clear framework for meaningful quantitative comparison. Read More

    Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure.
    Cerebrospinal Fluid Res 2009 Sep 11;6:11. Epub 2009 Sep 11.
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.
    Background: Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid (Abeta) peptides in the brain extracellular matrix, resulting in pathological changes and neurobehavioral deficits. Previous work from this laboratory demonstrated that the choroid plexus (CP) possesses the capacity to remove Abeta from the cerebrospinal fluid (CSF), and exposure to lead (Pb) compromises this function. Since metalloendopeptidase insulin-degrading enzyme (IDE), has been implicated in the metabolism of Abeta, we sought to investigate whether accumulation of Abeta following Pb exposure was due to the effect of Pb on IDE. Read More

    The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid.
    Cerebrospinal Fluid Res 2009 Sep 7;6:10. Epub 2009 Sep 7.
    Molecular Neurology, Huntington Medical Research Institutes, Pasadena, CA, 91101 USA.
    Background: Cerebrospinal fluid (CSF) contacts many brain regions and may mediate humoral signaling distinct from synaptic neurotransmission. However, synthesis and transport mechanisms for such signaling are not defined. The purpose of this study was to investigate whether human CSF contains discrete structures that may enable the regulation of humoral transmission. Read More

    Turnover rate of cerebrospinal fluid in female sheep: changes related to different light-dark cycles.
    Cerebrospinal Fluid Res 2009 Aug 4;6. Epub 2009 Aug 4.
    UMR: INRA - CNRS - Université François Rabelais de Tours - Haras nationaux 37380 Nouzilly, France.
    Background: Sheep are seasonal breeders. The key factor governing seasonal changes in the reproductive activity of the ewe is increased negative feedback of estradiol at the level of the hypothalamus under long-day conditions. It has previously been demonstrated that when gonadotropin secretions are inhibited during long days, there is a higher concentration of estradiol in the cerebrospinal fluid (CSF) than during short days. Read More

    CSF/serum quotient graphs for the evaluation of intrathecal C4 synthesis.
    Cerebrospinal Fluid Res 2009 Jul 2;6. Epub 2009 Jul 2.
    Central Laboratory of Cerebrospinal Fluid (LABCEL) Faculty of Medical Sciences "Dr Miguel Enriquez" Superior Institute of Medical Sciences of Havana AP 10049, 11000 CP Havana City, Cuba.
    Background: Cerebrospinal fluid (CSF)/serum quotient graphs have been used previously to determine local synthesis in brain of immunoglobulins and C3 complement component. The aim of this study was to use the same technique to construct quotient graphs, or Reibergrams, for the beta globulin C4 and to evaluate the method for assessing intrathecal synthesis in neurological disease.

    Methods: The constants in the previously-defined Reibergram for immunoglobulin IgA were used to calculate the CSF/serum quotient for C4. Read More

    Delamination technique together with longitudinal incisions for treatment of Chiari I/syringomyelia complex: a prospective clinical study.
    Cerebrospinal Fluid Res 2009 Jun 22;6. Epub 2009 Jun 22.
    Department of Neurosurgery, Haseki Educational and Research Hospital, Hasan Ali yücel sok,Senil apt, 36/14 Ciftehavuzlar Kadikoy, Istanbul, 34728 Turkey.
    Background: Treatment modalities in Chiari malformation type 1(CMI) accompanied by syringomyelia have not yet been standardized. Pathologies such as a small posterior fossa and thickened dura mater have been discussed previously. Various techniques have been explored to enlarge the foramen magnum and to expand the dura. Read More

    Neuropsychological assessment of attention in children with spina bifida.
    Cerebrospinal Fluid Res 2009 May 28;6. Epub 2009 May 28.
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
    Background: Children with the severe form of spina bifida (SBM: spina bifida with myelomeningocele with accompanying hydrocephalus) may manifest attention deficits, and have a similar psychological profile to children with hydrocephalus due to other etiologies. It is unclear to what extent tests to assess attention in SBM are confounded by the accompanying cognitive or visual-motor impairments. The aim of this study was to analyse attention functions by administering two different types of attention tests, one with high and the other with low cognitive and motor requirements. Read More

    Cerebrospinal fluid leakage after radioisotope cisternography is not influenced by needle size at lumbar puncture in patients with intracranial hypotension.
    Cerebrospinal Fluid Res 2009 May 27;6. Epub 2009 May 27.
    Sanno Hospital, Department of Neurosurgery, Akasaka 8-10-16, Minato-ku, Tokyo 107-0052, Japan.
    Background: Radioisotope (RI) cisternography is considered to be the most important examination for the final diagnosis of intracranial hypotension, typically indicating cerebrospinal fluid (CSF) leakage as RI parathecal activity. Early bladder filling (EBF) of RI is another important finding. However, whether EBF without parathecal activity represents real CSF leakage due to intracranial hypotension or only an epiphenomenon of lumbar puncture causing CSF leak through a needle hole has been questioned. Read More

    Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus.
    Cerebrospinal Fluid Res 2009 May 26;6. Epub 2009 May 26.
    Department of Neurosurgery, Division of Pediatric Neurosurgery, Primary Children's Medical Center and the University of Utah, Salt Lake City, Utah 84132, USA.
    Background: Previous studies in aging animals have shown that amyloid-beta protein (Abeta) accumulates and its transporters, low-density lipoprotein receptor-related protein-1 (LRP-1) and the receptor for advanced glycation end products (RAGE) are impaired during hydrocephalus. Furthermore, correlations between astrocytes and Abeta have been found in human cases of normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD). Because hydrocephalus occurs frequently in children, we evaluated the expression of Abeta and its transporters and reactive astrocytosis in animals with neonatal hydrocephalus. Read More

    Expression of TRPM8 in the distal cerebrospinal fluid-contacting neurons in the brain mesencephalon of rats.
    Cerebrospinal Fluid Res 2009 Mar 17;6. Epub 2009 Mar 17.
    Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, PR China.
    Background: It has been shown that distal cerebrospinal fluid-contacting neurons (dCSF-CNs) exist near the ventral midline of the midbrain aqueduct and also in the grey matter of the inferior third ventricle and the fourth ventricle floor in the superior segment of the pons. The dCSF-CNs communicate between the cerebrospinal fluid (CSF) and the brain parenchyma and may participate in the transduction and regulation of pain signals. The cold sensation receptor channel, TRPM8 is involved in analgesia for neuropathic pain, but whether the TRPM8 receptor exists on dCSF-CNs remains unknown. Read More

    Molecular diagnosis of Toxoplasma gondii infection in cerebrospinal fluid from AIDS patients.
    Cerebrospinal Fluid Res 2009 Mar 6;6. Epub 2009 Mar 6.
    Parasitology Department, Institute of Tropical Medicine 'Pedro Kourí', PO Box 601, Marianao 13, Ciudad de La Habana, Cuba.
    Background: Toxoplasmic encephalitis (TE) is one of the most common opportunistic infections in immunocompromised patients. In Cuba, despite the highly active antiretroviral therapy, TE is still the most important cause of cerebral mass lesions in patients infected with the human immunodeficiency virus (HIV). The detection of Toxoplasma gondii by PCR may facilitate the diagnosis and follow-up of TE in acquired immunodeficiency syndrome (AIDS) patients by direct identification of parasite DNA in clinical samples. Read More

    A review of the current treatment methods for posthaemorrhagic hydrocephalus of infants.
    Cerebrospinal Fluid Res 2009 Jan 30;6. Epub 2009 Jan 30.
    Department of Neurosurgery, Wessex Neurological Centre, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK.
    Posthaemorrhagic hydrocephalus (PHH) is a major problem for premature infants, generally requiring lifelong care. It results from small blood clots inducing scarring within CSF channels impeding CSF circulation. Transforming growth factor - beta is released into CSF and cytokines stimulate deposition of extracellular matrix proteins which potentially obstruct CSF pathways. Read More

    Neonatal high pressure hydrocephalus is associated with elevation of pro-inflammatory cytokines IL-18 and IFNgamma in cerebrospinal fluid.
    Cerebrospinal Fluid Res 2008 Dec 31;5:21. Epub 2008 Dec 31.
    Department of Pediatrics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands.
    Background: In human neonatal high pressure hydrocephalus (HPHC), diffuse white matter injury and gliosis predispose to poor neuro-developmental outcome. The underlying mechanism for diffuse white matter damage in neonatal HPHC is still unclear. Analogous to inflammatory white matter damage after neonatal hypoxemia/ischemia, we hypothesized that pro-inflammatory cytokines could be involved in neonatal HPHC. Read More

    Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour.
    Cerebrospinal Fluid Res 2008 Dec 29;5:20. Epub 2008 Dec 29.
    DevelopmentalBiology Unit UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
    Background: Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly affects the behaviour of the choroid plexus epithelium (CPe). The purpose of this study was to investigate expression of Fgf2 in rodent and human developing CPe and possible function of Fgf2, using in vitro models. The application of Fgf2 to brain in vivo can affect the whole tissue, making it difficult to assess specific responses of the CPe. Read More

    Hydrocephalus 2008, 17-20th September, Hannover Germany: a conference report.
    Cerebrospinal Fluid Res 2008 Dec 16;5:19. Epub 2008 Dec 16.
    Gagle Brook House, Chesterton, Bicester, Oxon, OX26 1UF, UK.
    Hydrocephalus 2008 was held 17-20 September in Hannover, Germany, at the invitation of Petra M Klinge (President), co-hosted by Joachim K. Krauss (Vice President), and Madjid Samii (Honorary President). This meeting was a successor to Hydrocephalus 2006 held in Göteborg, Sweden, organised by Past-President, Carsten Wikkelso. Read More

    Intrathecal synthesis of IgE in children with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis.
    Cerebrospinal Fluid Res 2008 Nov 25;5:18. Epub 2008 Nov 25.
    Central laboratory of CSF (LABCEL), Faculty of Medical Sciences "Dr Miguel Enríquez", Superior Institute of Medical Sciences of Havana, Section 10049, 11000 CP Havana City, Cuba.
    Background: Eosinophilic meningoencephalitis caused by the helminth Angiostrongylus cantonensis, is an emerging infectious disease in America. The objective of this paper was to determine if the intrathecal synthesis of immunoglobulin E is produced during the acute phase of the disease.

    Methods: Thirteen patients, mean age 4. Read More

    An experimental in-vivo canine model for adult shunt infection.
    Cerebrospinal Fluid Res 2008 Oct 24;5:17. Epub 2008 Oct 24.
    Department of Neurosurgery - S80, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
    Background: Detailed human studies of the mechanisms and development of shunt infection in real time are not possible, and we have developed a canine hydrocephalus model to overcome this. The intention of this pilot study was to show that the canine hydrocephalus model could be shunted using conventional "human" shunts, and that a shunt infection could be established so that further studies could then be planned.

    Methods: Hydrocephalus was induced in seven dogs (Canis familiaris) by fourth ventricle obstruction. Read More

    Hydrocephalus caused by conditional ablation of the Pten or beta-catenin gene.
    Cerebrospinal Fluid Res 2008 Oct 18;5:16. Epub 2008 Oct 18.
    Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, OH 43210, USA.
    To investigate the roles of Pten and beta-Catenin in the midbrain, either the Pten gene or the beta-catenin gene was conditionally ablated, using Dmbx1 (diencephalon/mesencephalon-expressed brain homeobox gene 1)-Cre mice. Homozygous disruption of the Pten or beta-catenin gene in Dmbx1-expressing cells caused severe hydrocephalus and mortality during the postnatal period. Conditional deletion of Pten resulted in enlargement of midbrain structures. Read More

    Evidence for reduced lymphatic CSF absorption in the H-Tx rat hydrocephalus model.
    Cerebrospinal Fluid Res 2008 Oct 16;5:15. Epub 2008 Oct 16.
    Hydrocephalus Research Laboratory, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.
    Background: There is mounting evidence that spinal fluid absorption takes place not only at the arachnoid villi, but also at several extracranial sites, which might serve as a reserve mechanism for, or be primarily involved in the absorption of CSF in hydrocephalus.

    Methods: We compared the nasal lymphatic pathway in congenital Hydrocephalus-Texas (H-Tx) rats in unaffected and affected hydrocephalic (HC) siblings with that of control Sprague Dawley (SD) rat pups. The animals were examined after immediate post mortem injection of Evan's blue dye into the cisterna magna at 6 and 10 days of age. Read More

    Cerebrospinal fluid markers in Creutzfeldt-Jakob disease.
    Cerebrospinal Fluid Res 2008 Aug 27;5:14. Epub 2008 Aug 27.
    Multidisciplinary Medical Laboratory, Akershus University Hospital, 1478, Lørenskog, Norway.
    Background: The objective was to assess the utility of total tau protein (tTau), the ratio of (tTau)/181 phosphorylated tau protein (P-Tau) and 14-3-3 protein, as diagnostic markers in cerebrospinal fluid (CSF) for Creutzfeldt-Jakob disease (CJD).

    Methods: CSF samples received from Norwegian hospitals between August 2005 and August 2007 were retrospectively selected from consecutive patients with tTau values > 1200 ng/L (n = 38). The samples from patients clinically diagnosed with CJD (n = 12) were compared to those from patients with other degenerative neurological diseases: Alzheimer's/vascular dementia (AD/VaD, n = 21), other neurological diseases (OND, n = 5). Read More

    Report on the second Intracranial Hypertension Research Foundation conference.
    Cerebrospinal Fluid Res 2008 Aug 13;5:13. Epub 2008 Aug 13.
    Intracranial Hypertension Research Foundation, 6517 Buena Vista Drive, Vancouver, WA 98661, USA.
    This report highlights a conference designed for patient education on elevated cerebrospinal fluid (CSF) pressure. The conference centered on chronic intracranial hypertension (IH) including the latest research and clinical information. It was sponsored by the Intracranial Hypertension Research Foundation and held at the University of Texas Medical School, Houston, on June 21-22nd, 2008. Read More

    Effect of hydrocephalus on rat brain extracellular compartment.
    Cerebrospinal Fluid Res 2008 Jul 10;5:12. Epub 2008 Jul 10.
    Department of Pathology, University of Manitoba, and Manitoba Institute of Child Health, Winnipeg MB, R3E 3P5, Canada.
    Background: The cerebral cortex may be compressed in hydrocephalus and some experiments suggest that movement of extracellular substances through the cortex is impaired. We hypothesized that the extracellular compartment is reduced in size and that the composition of the extracellular compartment changes in rat brains with kaolin-induced hydrocephalus.

    Methods: We studied neonatal (newborn) onset hydrocephalus for 1 or 3 weeks, juvenile (3 weeks) onset hydrocephalus for 3-4 weeks or 9 months, and young adult (10 weeks) onset hydrocephalus for 2 weeks, after kaolin injection. Read More

    The effect of whole body position on lumbar cerebrospinal fluid opening pressure.
    Cerebrospinal Fluid Res 2008 Jul 2;5:11. Epub 2008 Jul 2.
    Division of Neurology, Phramongkutklao Hospital and College of Medicine, Bangkok, 10400, Thailand.
    We compared cerebrospinal fluid (CSF) opening pressure measurements in the lumbar subarachnoid space between the flexed position (F-OP) and relaxed position (R-OP) in recumbent patients. We devised an equation for using F-OP to determine the existence of raised intracranial pressure (ICP). Patients (n = 83) underwent lumbar puncture while in the flexed lateral decubitus position and then were moved to the relaxed position. Read More

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