112,560 results match your criteria Cerebrospinal Fluid Leak Imaging


Detection of Pediatric Bacterial Meningitis Pathogens from Cerebrospinal Fluid by Next-Generation Sequencing Technology.

J Infect 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China. Electronic address:

Objectives: Bacterial meningitis remains one of the major challenges in infectious diseases, leading to sequel in many cases. A prompt diagnosis of the causative microorganism is critical to significantly improve outcome of bacterial meningitis. Although various targeted tests for cerebrospinal fluid (CSF) samples are available, it is a big problem for the identification of etiology of bacterial meningitis. Read More

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December 2018

[The surgical management of upper parapharyngeal regions].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1804-1809

Department of Otorhinolaryngology, the First Affiliated Hospital, Bengbu Medical College, Bengbu, 233004, China.

To find proper the surgical approval and evaluate clinical efficacy to treat the tumor of upper parapharyngeal space involving the base of skull and intracranial skull. The data of 9 cases from June 2013 and June 2018 were analyzed retrospectively including schwannoma in 6 cases, pleomorphic adenoma in 2 cases and hemangioma in 1 case. All cases received preoperative high resolution CT and MRI, some cases also did the DSA examination. Read More

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December 2018
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[Application of image-guided system in endoscopic sinus and skull base surgery].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1856-1859

Department of Otorhinolaryngology Head and Neck Surgery, Huadong Hospital, Fudan University, Shanghai, 200040,China.

To evaluate the applicative value of image-guided system in endoscopic sinus and skull base surgeries. A total of 103 endoscopic surgical procedures were performed.All these procedures were conducted with the utilization of image-guided system, among which there were 92 cases of sinonasal-skull base surgery(including nasal sinuses resection of benign and malignant tumors involving skull base lesions, the cumulative orbital lesion resection of nasal sinus lesions, etc. Read More

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December 2018

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.

Acta Neuropathol 2018 Dec 13. Epub 2018 Dec 13.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborgsvägen 31, House V3/SU, 43180, Mölndal, Sweden.

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer's disease (AD). Most of tau in CSF is present as fragments. Read More

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December 2018

Building a network for multicenter, prospective research of central nervous system infections in South America: Process and lessons learned.

eNeurologicalSci 2018 Dec 4;13:63-69. Epub 2018 Jul 4.

Hospital Emergencias Pediatricas, Lima, Peru.

Multicenter collaborative networks are essential for advancing research and improving clinical care for a variety of conditions. Research networks are particularly important for central nervous system infections, which remain difficult to study due to their sporadic occurrence and requirement for collection and testing of cerebrospinal fluid. Establishment of long-term research networks in resource-limited areas also facilitates diagnostic capacity building, surveillance for emerging pathogens, and provision of appropriate treatment where needed. Read More

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December 2018

Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis.

Sci Adv 2018 Dec 12;4(12):eaav1781. Epub 2018 Dec 12.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

The etiopathogenesis of idiopathic scoliosis (IS), a highly prevalent spinal deformity that occurs in the absence of obvious congenital or physiological abnormalities, is poorly understood. Although recent zebrafish genetic studies have linked cilia motility and cerebrospinal fluid (CSF) flow defects with scoliosis progression, underlying mechanisms were not identified. Here, we use next-generation sequencing and conditional genetic methodologies to define the spatial and biological origins of spinal curve formation in mutant zebrafish, a faithful IS model. Read More

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December 2018

Dynamic changes and diagnostic and prognostic significance of serum PCT, hs-CRP and s-100 protein in central nervous system infection.

Exp Ther Med 2018 Dec 16;16(6):5156-5160. Epub 2018 Oct 16.

Inspection Department, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China.

The aim of the study was to analyze the dynamic changes and diagnostic and prognostic significance of serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and s-100 protein in central nervous system infection. A total of 110 patients diagnosed with central nervous system infection in Department of Neurology in the People's Hospital of Rizhao from January 2014 to January 2016 were selected and retrospectively analyzed; they were divided into the bacterium (n=70) and virus (n=40) groups. Another 45 normal subjects were selected as the control group. Read More

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December 2018

Comparison of Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Elizabethkingia meningoseptica and Elizabethkingia anophelis Isolated in Taiwan.

J Clin Med 2018 Dec 11;7(12). Epub 2018 Dec 11.

School of Medicine, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan.

and Elizabethkingia are two major pathogens in the genus . Studies have revealed that Elizabethkingia is frequently misidentified as . Therefore, our aim was to explore the clinical and molecular differences between these two species. Read More

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December 2018

Anti-Mycobacterial Antibodies in Paired Cerebrospinal Fluid and Serum Samples from Japanese Patients with Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Department of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.

Local synthesis of antibodies and presence of oligoclonal bands in the cerebrospinal fluid (CSF) are hallmarks of multiple sclerosis (MS). We investigated the frequency of antibodies against mycobacterial and relevant human epitopes in the CSF of patients with MS or neuromyelitis optica spectrum disorder (NMOSD) and whether these antibodies differed from those present in the serum. Matched serum and CSF samples from 46 patients with MS, 42 patients with NMOSD, and 29 age-matched and sex-matched control subjects were screened retrospectively for the presence of antibodies against subsp. Read More

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December 2018

Incomplete intestinal obstruction as an initial and persistent presentation in chronic inflammatory demyelinating polyneuropathy: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13538

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei.

Rationale: Autonomic symptoms are not uncommon in chronic inflammatory demyelinating polyneuropathy (CIDP), but they are mostly mild and transient and are overshadowed by somatic manifestations. Here, we report a very unusual case of CIDP with severe autonomic symptom, intestinal obstruction, as initial and persistent symptom which responded well to high-dose glucocorticoid and intravenous immunoglobulin treatment.

Patient Concerns: We described a patient with CIDP with precedent and long-lasting incomplete intestinal obstruction. Read More

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December 2018

Mesalazine treatment causing resolution of intracranial hypertension secondary to ulcerative colitis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13365

Department of Ophthalmology, Fondation Ophtalmologique Adolphe de Rothschild.

Rationale: The association between intracranial hypertension (ICH) and ulcerative colitis (UC) is rare. We report the unusual case of a male patient with UC and ICH in whom both conditions resolved with mesalazine therapy.

Patient Concerns: A 48-year-old Caucasian man presented to our department in June 2016 for decreased vision, transient visual obscuration, pulsatile tinnitus and headaches of 7 months duration. Read More

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December 2018

Neuroendoscopic fenestration of glioependymal cysts to the ventricle: report of 3 cases.

Authors:

J Neurosurg 2018 Nov 1:1-5. Epub 2018 Nov 1.

Glioependymal cysts are rare congenital lesions of the central nervous system. Reported surgical treatments of these lesions have varied and yielded mixed results, and the optimal surgical strategy is still controversial. The authors here report the clinical and surgical outcomes for three adult patients successfully treated with neuroendoscopic fenestration into the ventricular system. Read More

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November 2018

Aneurysm rebleeding before therapy: a predictable disaster?

Authors:

J Neurosurg 2018 Nov 1:1-8. Epub 2018 Nov 1.

OBJECTIVECurrent guidelines for subarachnoid hemorrhage (SAH) include early aneurysm treatment within 72 hours after ictus. However, aneurysm rebleeding remains a crucial complication of SAH. The aim of this study was to identify independent predictors allowing early stratification of SAH patients for rebleeding risk. Read More

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November 2018

Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis.

Authors:

J Neurosurg 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEMicrovascular decompression (MVD) is commonly used in the treatment of trigeminal neuralgia (TN) with positive clinical outcomes. Fully endoscopic MVD (E-MVD) has been proposed as an effective minimally invasive alternative, but a comparative review of the two approaches has not been conducted. The authors performed a meta-analysis of studies, comparing patient outcome rates and complications for the open versus the endoscopic technique. Read More

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December 2018

A novel index for assessing treatment plan quality in stereotactic radiosurgery.

Authors:

J Neurosurg 2018 Dec;129(Suppl1):118-124

OBJECTIVEStereotactic radiosurgery (SRS) is characterized by high levels of conformity and steep dose gradients from the periphery of the target to surrounding tissue. Clinical studies have backed up the importance of these factors through evidence of symptomatic complications. Available data suggest that there are threshold doses above which the risk of symptomatic radionecrosis increases with the volume irradiated. Read More

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December 2018

Cytokines and Tissue Damage Biomarkers in First-Onset Neuromyelitis Optica Spectrum Disorders: Significance of Interleukin-6.

Neuroimmunomodulation 2018 Dec 13:1-10. Epub 2018 Dec 13.

Neuroinfection and Neuroimmunology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing,

Objective: We investigated the contribution of several cytokines in the pathogenesis of first-onset neuromyelitis optica spectrum disorder (NMOSD) and determined the differences between aquaporin 4 immunoglobulin G (AQP4-IgG)-positive and AQP4-IgG-negative subtypes.

Methods: We enrolled 18 NMOSD (10 AQP4-IgG-positive and 8 AQP4-IgG-negative) and 8 multiple sclerosis (MS) patients, whose serum and cerebrospinal fluid (CSF) samples were collected during the acute phase of the first onset before immunotherapy. Fifteen patients with other noninflammatory neurological diseases (OND) were also included. Read More

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December 2018

Cerebrospinal fluid biomarker for Parkinson's disease: An overview.

Mol Cell Neurosci 2018 Dec 10. Epub 2018 Dec 10.

University Medical Center, Department of Neurology, Robert-Koch Strasse 40, 37075 Goettingen, Germany.

In Parkinson's disease (PD), there is a wide field of recent and ongoing search for useful biomarkers for early and differential diagnosis, disease monitoring or subtype characterization. Up to now, no biofluid biomarker has entered the daily clinical routine. Cerebrospinal fluid (CSF) is often used as a source for biomarker development in different neurological disorders because it reflects changes in central-nervous system homeostasis. Read More

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December 2018

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5876-5884

Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Purpose: To determine whether cerebrospinal fluid (CSF) entry into the optic nerve is altered in glaucoma.

Methods: Fluorescent 10-kDa dextran tracer was injected into the CSF of 2-month-old (n = 9) and 10-month-old DBA/2J glaucoma mice (n = 8) and age-matched controls (C57Bl/6; n = 8 each group). Intraocular pressure (IOP) was measured in all mice before tracer injection into CSF. Read More

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December 2018

Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG (CONNECT-ME): Protocol for a Longitudinal Prospective Study and a Tertiary Clinical Care Service.

Front Neurol 2018 27;9:1012. Epub 2018 Nov 27.

Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

To facilitate individualized assessment of unresponsive patients in the intensive care unit for signs of preserved consciousness after acute brain injury. Physicians and neuroscientists are increasingly recognizing a disturbing dilemma: Brain-injured patients who appear entirely unresponsive at the bedside may show signs of covert consciousness when examined by functional MRI (fMRI) or electroencephalography (EEG). According to a recent meta-analysis, roughly 15% of behaviorally unresponsive brain-injured patients can participate in mental tasks by modifying their brain activity during EEG- or fMRI-based paradigms, suggesting that they are conscious and misdiagnosed. Read More

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November 2018

Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer's disease.

Fluids Barriers CNS 2018 Dec 12;15(1):34. Epub 2018 Dec 12.

Department of Neurosurgery, Stanford University, 710 Frenchmans Rd, Stanford, CA, 94305, USA.

Background: The roles of the choroid plexus (CP) and cerebrospinal fluid (CSF) production have drawn increasing attention in Alzheimer's disease (AD) research. Specifically, studies document markedly decreased CSF production and turnover in moderate-to-severe AD. Moreover, reduced CP function and CSF turnover lead to impaired clearance of toxic metabolites, likely promote neuroinflammation, and may facilitate neuronal death during AD progression. Read More

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December 2018

Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach.

BMC Public Health 2018 Dec 13;18(Suppl 4):1318. Epub 2018 Dec 13.

World Health Organisation, Country Representative Office, Abuja, Nigeria.

Background: Kebbi State remains the epicentre of the seasonal epidemic meningitis in northwestern Nigeria despite interventions. In this setting, no previous study has been conducted to understand the risk factors of the recurrent meningitis epidemics using qualitative approach. Consequently, this study intends to explore and better understand the environmental, economic and socio-cultural factors of recurrent seasonal epidemic meninigitis using a qualitative approach. Read More

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December 2018

Point-of-care testing for procalcitonin in identifying bacterial infections in young infants: a diagnostic accuracy study.

BMC Pediatr 2018 Dec 12;18(1):387. Epub 2018 Dec 12.

Centre for Experimental Medicine, Wellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.

Background: The primary objective of this study was to report on the diagnostic accuracy of point-of-care testing (POCT) for procalcitonin (PCT) in identifying invasive bacterial infections in young infants. Invasive bacterial infection was defined as the isolation of a bacterial pathogen in blood or cerebrospinal fluid culture.

Methods: This was a prospective observational diagnostic accuracy study. Read More

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December 2018

Cerebrospinal fluid and the early brain development of autism.

Authors:
Mark D Shen

J Neurodev Disord 2018 Dec 13;10(1):39. Epub 2018 Dec 13.

Carolina Institute for Developmental Disabilities, Department of Psychiatry, and the UNC Intellectual and Developmental Disabilities Research Center, University of North Carolina at Chapel Hill School of Medicine, Campus Box 3367, Chapel Hill, NC, 27599-3367, USA.

Background: There is currently a renaissance of interest in the many functions of cerebrospinal fluid (CSF). Altered flow of CSF, for example, has been shown to impair the clearance of pathogenic inflammatory proteins involved in neurodegenerative diseases, such as amyloid-β. In addition, the role of CSF in the newly discovered lymphatic system of the brain has become a prominently researched area in clinical neuroscience, as CSF serves as a conduit between the central nervous system and immune system. Read More

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December 2018

Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

J Vet Diagn Invest 2018 Dec 12:1040638718816358. Epub 2018 Dec 12.

Laboratories of Animal Pathology (Headley, Michelazzo, Oliveira), Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil.

We describe the pathologic, histochemical, and immunohistochemical findings associated with pulmonary and encephalitic cryptococcosis in a 3-y-old, mixed-breed, nanny goat from central-west Brazil. The goat had progressive neurologic signs over 30 d; cryptococcosis was diagnosed antemortem by cytologic evaluation of cerebrospinal fluid. Treatment was initiated, but the animal died spontaneously shortly thereafter. Read More

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December 2018

Loss of Ca/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease.

Front Mol Biosci 2018 20;5:99. Epub 2018 Nov 20.

Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada.

Ca/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine kinase that is activated following an increase in the intracellular Ca concentration and activates multiple signaling cascades that control physiologically important neuronal processes. CaMKK2 has been implicated in schizophrenia, bipolar disease, neurodegeneration, and cancer. Using isoelectric focusing (IEF) and mass spectrometry-based proteomic analysis, it was found that knockdown (KD) of CaMKK2 in cultured adult primary dorsal root ganglion (DRG) neurons resulted in the reduction of transferrin (TF) phosphorylation at multiple functionally relevant residues which corresponded to loss of an acidic fraction (pH~3-4) of TF. Read More

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November 2018

United Kingdom CSF Disorders Day 2017.

Neuroophthalmology 2018 Dec 25;42(6):414-417. Epub 2018 Apr 25.

Birmingham Neuro-ophthalmology Unit, University Hospital Birmingham, Edgbaston, Birmingham, UK.

The management of patients with cerebrospinal fluid disorders requires a multi-specialty approach involving specialists in neurosurgery, neurology, neuroradiology and neuro-ophthalmology. A symposium on CSF disorders was organised by the clinical and academic teams at University Hospitals Birmingham, United Kingdom. The meeting featured a synopsis of the latest scientific research on CSF disorders. Read More

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December 2018

Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease.

Front Physiol 2018 21;9:1640. Epub 2018 Nov 21.

State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China.

The potential function of distal cerebrospinal fluid-contacting nucleus (dCSF-CNs) in chronic kidney disease (CKD) development is poorly understood. We hypothesized that dCSF-CNs might affect the renin-angiotensin system (RAS) in kidney injury progression, with dCSF-CNs ablation potentially alleviating local RAS and renal fibrosis in rats after five-sixths nephrectomy (5/6Nx). Part of rats were randomly administered artificial cerebrospinal fluid (aCSF) intracerebroventricularly (icv), followed by 5/6Nx or sham operation; and other part of rats were administered Cholera toxin B subunit conjugated with saporin (CB-SAP) for dCSF-CNs lesion before 5/6Nx. Read More

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November 2018

Cerebral Vascular Changes During Acute Intracranial Pressure Drop.

Neurocrit Care 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiological Nursing, University of California, 2 Koret Way, San Francisco, CA, 94143, USA.

Objective: This study applied a new external ventricular catheter, which allows intracranial pressure (ICP) monitoring and cerebral spinal fluid (CSF) drainage simultaneously, to study cerebral vascular responses during acute CSF drainage.

Methods: Six patients with 34 external ventricular drain (EVD) opening sessions were retrospectively analyzed. A published algorithm was used to extract morphological features of ICP recordings, and a template-matching algorithm was applied to calculate the likelihood of cerebral vasodilation index (VDI) and cerebral vasoconstriction index (VCI) based on the changes of ICP waveforms during CSF drainage. Read More

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December 2018

The Incidence of Meningitis in Patients with Traumatic Brain Injury Undergoing External Ventricular Drain Placement: A Nationwide Inpatient Sample Analysis.

Neurocrit Care 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.

Background/objective: Infection is the most common complication of external ventricular drain (EVD) placement. National trends in the annual incidence of meningitis among patients with traumatic brain injury (TBI) who have undergone EVD placement have not been reported.

Methods: The Nationwide Inpatient Sample was used to select adults with a primary diagnosis of TBI who underwent EVD placement between 2002 and 2011. Read More

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December 2018

[A Case of Sjögren's Syndrome with Multiple Stenoses of the Cerebral Arteries and Transient Neurological Symptoms and Signs].

Brain Nerve 2018 Dec;70(12):1389-1396

Department of Neurology, Japanese Red Cross Yamaguchi Hospital.

A 31-year-old woman was admitted to the hospital after several episodes of transient numbness in her fingers and dysarthria. No neurological symptoms and signs were observed in this patient on admission; however, blood tests revealed elevated amylase and immunoglobulin G levels, an increased erythrocyte sedimentation rate, and positive anti-Sjögren's-syndrome (SjS)-related antigen A antibodies. The cerebrospinal fluid examination revealed a slight increase in the cell count and protein content. Read More

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December 2018

Ibrutinib for the treatment of Bing-Neel syndrome: A multicenter study.

Blood 2018 Dec 6. Epub 2018 Dec 6.

Bing Center for Waldenstrom Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.

The treatment of patients with Bing-Neel syndrome (BNS) is not standardized. We included patients with Waldenstrom macroglobulinemia (WM) and a radiological and/or cytological diagnosis of BNS treated with ibrutinib monotherapy. Response assessment was based on criteria for BNS from the 8th International Workshop for WM. Read More

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December 2018

A comparative study of the pharmacokinetics of clozapine N-oxide and clozapine N-oxide hydrochloride salt in rhesus macaques.

J Pharmacol Exp Ther 2018 Dec 6. Epub 2018 Dec 6.

Oregon Health & Science University;

Translating chemogenetic techniques from non-human primates to potential clinical applications has been complicated in part due to in vivo conversion of the chemogenetic actuator, clozapine N-oxide (CNO), to its pharmacologically active parent compound, clozapine, a ligand with known side-effects, including five FDA boxed warnings. Additionally, the limited solubility of CNO requires high concentrations of potentially toxic detergents such as dimethyl sulfoxide (DMSO). To address these concerns, pharmacokinetic profiling of commercially available CNO in DMSO (CNO-DMSO, 10% v/v DMSO in saline) and a water-soluble salt preparation (CNO-HCl, saline) was conducted in rhesus macaques. Read More

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December 2018
3.972 Impact Factor

Comparison of Candesartan and Angiotensin-(1-7) Combination and Mito Tempo Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (Mren2)27 Rats.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.

Hypertensive transgenic (mRen2)27 rats exhibit impaired baroreflex sensitivity (BRS) for control of heart rate (HR). Intracerebroventricular (ICV) infusion of Ang-(1-7) improves indices of vagal BRS independent of lowering mean arterial pressure (MAP), while AT1 receptor blockade normalizes MAP and indices of sympathetic tone without correcting the vagal BRS. Scavenging cellular reactive oxygen species (ROS) with tempol in brain fails to correct either hypertension or sympathovagal balance in these animals, despite reports that mitochondrial ROS contributes to Ang II-infusion hypertension. Read More

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December 2018
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Importance of cerebrospinal fluid investigation during dengue infection in Brazilian Amazonia Region.

Mem Inst Oswaldo Cruz 2018 Dec 10;114:e180450. Epub 2018 Dec 10.

Universidade Federal do Estado do Rio de Janeiro/Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

BACKGROUND Amazon, the largest tropical forest of the world, has suffered from dengue outbreaks since 1998. Cerebrospinal fluid (CSF) of patients, from Amazonas state, suspected of central nervous system (CNS) viral infection was studied using molecular and immunological methods. OBJECTIVE To evaluate the importance of CSF investigation in patients with acute dengue virus (DENV) infection of CNS. Read More

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December 2018

Biobanking of Cerebrospinal Fluid.

Methods Mol Biol 2019 ;1897:107-114

Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various infectious and inflammatory disorders, such as meningitis and multiple sclerosis. However, there has been increasing interest in collecting CSF in order to study the clinical significance of additional biomarkers. Read More

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January 2019

Impact of diabetes mellitus on outcomes in patients with brain metastasis treated with stereotactic radiosurgery.

J Radiosurg SBRT 2018 ;5(4):285-291

Department of Radiation Oncology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.

Purpose: To determine the influence of diabetes mellitus (DM) on outcomes in patients with brain metastasis treated with stereotactic radiosurgery (SRS).

Methods: We retrospectively reviewed 498 patients with brain metastasis treated at our institution with SRS between January 2012 and March 2017.

Results: Eight-four patients (16. Read More

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January 2018

Laparoscopic Resection of Advanced Colorectal Cancer in a Patient with Lumboperitoneal Shunt.

Case Rep Surg 2018 14;2018:6826079. Epub 2018 Nov 14.

Department of Surgery, Nagoya Tokushukai General Hospital, 2-52 Kouzouji-cho kita, Kasugai-City, Aichi 487-0016, Japan.

A 78-year-old woman with lumboperitoneal (LP) shunt was diagnosed with advanced cancer of the ascending colon. Laparoscopic right hemicolectomy was performed without manipulating the catheter. The patient's postoperative course was uneventful, with no shunt-related complications or neurological deficit. Read More

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November 2018
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Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey.

Front Neurol 2018 27;9:997. Epub 2018 Nov 27.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Several case reports have described the concurrence of chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN). The presence of autoantibodies against podocyte antigens phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A) in MN suggests an autoimmune mechanism. Some CIDP patients also harbor autoantibodies against paranodal proteins such as neurofascin 155 (NF155) and contactin-1 (CNTN1). Read More

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November 2018

The Meningococcal Cysteine Transport System Plays a Crucial Role in Survival in Human Brain Microvascular Endothelial Cells.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

RIKEN Structural Biology Laboratory, Yokohama, Japan.

While typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of human cells are not always conducive to meningococci, needs to exploit nutrients from host environments. In the present study, the utilization of cysteine by the meningococcal cysteine transport system (CTS) was analyzed for the pathogenesis of meningococcal infections. Read More

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December 2018
2 Reads

Prospective study of clinical, neurophysiological and urodynamic findings in multiple scleosis patients undergoing percutaneous transluminal venous angioplasty.

Clin Neurophysiol 2018 Nov 26;130(1):138-144. Epub 2018 Nov 26.

Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Italy. Electronic address:

Objective: Verify whether Percutaneous Transluminal Angioplasty (PTA) may affect neural conduction properties in Multiple Sclerosis (MS) patients, thereby modifying patients' disability, with prospective neurophysiological, urodynamic, clinical and subjective well-being evaluations.

Methods: In 55 out of 72 consecutively screened MS patients, the following procedures were carried out before (T0), at 2-6 months (T1) and at 6-15 months (T2) after a diagnostic phlebography, eventually followed by the PTA intervention if chronic cerebrospinal venous insufficiency (CCSVI) was diagnosed: clinical/objective evaluation (Expanded Disability Status Scale, EDSS), ratings of subjective well-being, evaluation of urodynamic functions and multimodal EPs (visual, acoustic, upper and lower limbs somatosensory and motor evoked potentials).

Results: The number of dropouts was relatively high, and a complete set of neurophysiological and clinical data remained available for 37 patients (19 for urological investigations). Read More

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November 2018

Otopathology in Angiosarcoma of the Temporal Bone.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.

Objectives/hypothesis: Investigate the otopathology of angiosarcoma of the temporal bone, which has not been previously described in the literature.

Study Design: Postmortem evaluation and literature review.

Methods: Postmortem histological evaluation of the temporal bones and review of the literature for the treatment and prognosis of this rare disease were performed. Read More

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December 2018
4 Reads

Safety, Tolerability, and Pharmacodynamics of Intrathecal Injection of Recombinant Human HGF (KP-100) in Subjects With Amyotrophic Lateral Sclerosis: A Phase I Trial.

J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Hepatocyte growth factor is an endogenous pleiotropic factor shown to act as a potent neuroprotectant against disease progression in animal models of amyotrophic lateral sclerosis, which is a devastating, adult-onset motor neuron disease. To evaluate the safety, tolerability, and pharmacokinetics of recombinant 5-residue-deleted human hepatocyte growth factor (KP-100) injected intrathecally through an implantable catheter connected to a subcutaneous port, we conducted a first-in-human phase I trial of intrathecal KP-100 in 15 Japanese patients with amyotrophic lateral sclerosis. The regimen was a single injection of 3 escalating doses (0. Read More

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December 2018
2 Reads

Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study.

Spec Care Dentist 2018 Dec 11. Epub 2018 Dec 11.

Assistant Professor of Linguistics, Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Read More

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December 2018

[Neonatal viral meningitis. The importance of the polymerase chain reaction in their diagnosis].

Rev Neurol 2018 Dec;67(12):484-490

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

Introduction: The different types of viral meningitis constitute a condition that is relatively frequent in newborn infants, although in many cases they are underdiagnosed due to the absence of pleocytosis in the cerebrospinal fluid (CSF).

Aims: To describe the clinical features and laboratory findings of newborn infants with viral meningitis and to highlight the importance of the polymerase chain reaction (PCR) in the CSF to diagnose this condition.

Patients And Methods: A retrospective review of the medical records of newborn infants hospitalised in the neonatology section who had been diagnosed with viral meningitis between May 2014 and May 2017. Read More

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December 2018

The application of nasoseptal "rescue" flap technique in endoscopic transsphenoidal pituitary adenoma resection.

Neurosurg Rev 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Qilu Hospital, Shandong University, 107 Wenhua Western Rd., Jinan, 250012, Shandong, China.

To explore the reliability and superiority of nasoseptal "rescue" flap technique in neuroendoscopic transnasal pituitary adenoma resection. Retrospective clinical analysis of 113 cases of endoscopic transsphenoid pituitary adenoma resection with the application of nasoseptal "rescue" flap technology. The reliability and the superiority of the technique were evaluated according to the duration of nasal cavity and sphenoid sinus stage, the incidence of postoperative anosmia, and cerebrospinal rhinorrhea. Read More

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December 2018

Endoscopic endonasal resection of symptomatic Rathke cleft cysts: clinical outcomes and prognosis.

Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More

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December 2018
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Predictors of cognitive function in the acute phase after aneurysmal subarachnoid hemorrhage.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, P.B. 4950, Nydalen, 0424, Oslo, Norway.

Background: Cognitive dysfunction is the most common form of neurological impairment after aneurysmal subarachnoid hemorrhage (aSAH) in the chronic phase. Cognitive deficits in the acute phase after aSAH, however, remain scarcely investigated. The aim of the present study was to test cognitive function and to identify medical predictors of cognitive deficits in the acute phase of aSAH. Read More

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December 2018
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Quantification of Cerebellar Crowding in Type I Chiari Malformation.

Ann Biomed Eng 2018 Dec 7. Epub 2018 Dec 7.

Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA.

This study was focused on a semi-automated morphometric analysis of the cerebellum in the mid-sagittal plane as an alternative to tonsillar descent alone in the evaluation of Chiari malformation type 1 (CMI) patients. Morphometric analyses of posterior fossa structures were performed on mid-sagittal MRI images of 375 individuals (females, > 18 years, 235 CMI and 140 healthy controls). Twenty-six parameters including linear, angular and area measurements together with non-dimensional ratios were calculated. Read More

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December 2018

Growth of Lumbosacral Perineural (Tarlov) Cysts: A Natural History Analysis.

Neurosurgery 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Tarlov cysts (TC) are commonly found spinal perineural cysts. Symptomatic TCs are rare, however, and there is no consensus on their pathogenesis and optimal management.

Objective: To characterize cyst growth in patients with symptomatic TCs. Read More

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December 2018

Small extracellular vesicles in rat serum contain astrocyte-derived protein biomarkers of repetitive stress.

Int J Neuropsychopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Centro de Investigación Biomédica, Universidad de los Andes, Chile.

Background: Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence of disease subtypes. Using an animal model, we previously described that repetitive stress via restraint or immobilization induced depressive-like behaviors in rats that were differentially reverted by a serotonin- or noradrenaline-based antidepressant drug, indicating that different neurobiological mechanisms may be involved. The forebrain astrocyte protein aldolase C, contained in small extracellular vesicles (sEVs), was identified as a potential biomarker in the cerebrospinal fluid, however its specific origin remains unknown. Read More

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December 2018