6,803 results match your criteria Cerebral Venous Thrombosis


Fungal Malignant Otitis Externa Involves a Cascade of Complications Culminating in Pseudoaneurysm of Internal Maxillary Artery: A Case Report.

Am J Case Rep 2019 Apr 21;20:562-566. Epub 2019 Apr 21.

Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Pseudomonal infection is the most common cause of malignant otitis externa (MOE), which typically affects elderly diabetic patients. Fungi are a rare cause of MOE. MOE can be life-threatening if not recognized and treated promptly. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913469
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http://dx.doi.org/10.12659/AJCR.913469DOI Listing
April 2019
1 Read

Etiologic and Clinical Features of Cerebral Venous Sinus Thrombosis in Saudi Arabia.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):278-282

Department of Medicine, Division of Neurology, 7-112L Clinical Sciences Building, University of Alberta, Edmonton, Canada.

Objective: Our study aims to evaluate the etiologic and clinical features of cerebral venous sinus thrombosis (CVST) in Saudi Arabia, and secondarily whether gender plays a role in CVST.

Materials And Methods: Data were collected retrospectively from the stroke registry during the period from January 2008 to April 2018, and the patients with the diagnosis of CVST were identified, and data were analyzed for any gender-specific differences in clinical presentation and etiology of cerebral venous thrombosis.

Results: There were 15 females while 11 males with a female:male ratio of 1. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/278/254
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http://dx.doi.org/10.4103/jnrp.jnrp_305_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454937PMC
April 2019
2 Reads

Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review protocol.

Syst Rev 2019 Apr 18;8(1):99. Epub 2019 Apr 18.

Department of Medicine, University of Ottawa and The Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada.

Background And Purpose: Cerebral venous thrombosis causes disability from venous infarct and hemorrhage and potential mortality. Anticoagulation improves survival and disability outcomes, yet direct oral anticoagulants are currently not indicated in cerebral venous thrombosis due to lack of evidence, despite being on the market for nearly a decade. This systematic review will collate evidence of reported safety and efficacy of direct oral anticoagulant therapy in cerebral venous thrombosis. Read More

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http://dx.doi.org/10.1186/s13643-019-1022-8DOI Listing

Cerebral venous thrombosis in adults.

Vasa 2019 Apr 17:1-10. Epub 2019 Apr 17.

1 Vivantes Klinikum im Friedrichshain, Berlin, Germany.

Thromboses of cerebral veins and/or sinuses (CVT) encompass a clinically rather heterogenous, relatively rare entity, which is nonetheless an important cause of stroke in the young. While until the mid of the last century the prognosis of CVT was thought to be poor or even fatal in the majority of cases, the advance and wider use of modern imaging technology since the early 1980s, together with the results of registries and population-based studies, revealed that CVT is more frequent and less life-threatening than previously assumed. However, because headache is frequently the only symptom, many oligosymptomatic cases might be overlooked. Read More

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https://econtent.hogrefe.com/doi/10.1024/0301-1526/a000788
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http://dx.doi.org/10.1024/0301-1526/a000788DOI Listing
April 2019
2 Reads

Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

Ann Intensive Care 2019 Apr 16;9(1):47. Epub 2019 Apr 16.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current standards for the clinical assessment of altered consciousness states (including coma and delirium) and peripheral nervous system in critically ill patients, monitoring of brain function (specifically, electro-encephalography) and best practices for sedation-analgesia-delirium management. An update on the treatment of specific severe brain pathologies-including ischaemic/haemorrhagic stroke, cerebral venous thrombosis, hypoxic-ischaemic brain injury, immune-mediated and infectious encephalitis and refractory status epilepticus-was also provided. Read More

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http://dx.doi.org/10.1186/s13613-019-0523-xDOI Listing
April 2019
1 Read

Risk factors associated with recurrent venous thromboembolism after a first cerebral venous thrombosis event: A cohort study.

Thromb Res 2019 Apr 10;178:85-90. Epub 2019 Apr 10.

Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, Brazil; Hematology Unit, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, Brazil. Electronic address:

Background: Cerebral venous thrombosis (CVT), although rare, is potentially fatal. Few studies have investigated risk factors associated with recurrent venous thromboembolism (VTE) after a first CVT event of which most are from Caucasian populations. The aim of this study was to evaluate risk factors associated with recurrent VTE after a first CVT event in a South American-population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193019
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http://dx.doi.org/10.1016/j.thromres.2019.04.008DOI Listing
April 2019
2 Reads

Cerebral Venous Thrombosis.

Am J Med Sci 2019 Mar 9. Epub 2019 Mar 9.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00029629193009
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http://dx.doi.org/10.1016/j.amjms.2019.03.001DOI Listing
March 2019
2 Reads

Endovascular mechanical thrombectomy for cerebral venous sinus thrombosis: a single center experience.

World Neurosurg 2019 Apr 10. Epub 2019 Apr 10.

Department of Diagnostic and Interventional Neuroradiology, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany.

Background: Cerebral venous thrombosis (CVT) is a rare entity with a potentially fatal outcome. Especially patients who do not respond to standard medical therapy alone may benefit from endovascular treatment options. We evaluate the angiographic and clinical results of mechanical thrombectomy (MT) in patients with severe CVT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193104
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http://dx.doi.org/10.1016/j.wneu.2019.04.049DOI Listing
April 2019
4 Reads

Development of bilateral dural arteriovenous fistulae following pial synangiosis for moyamoya syndrome: case report.

J Neurosurg Pediatr 2019 Apr 12:1-5. Epub 2019 Apr 12.

Departments of1Neurosurgery and.

Moyamoya syndrome predisposes patients to ischemic or hemorrhagic stroke due to progressive narrowing of intracranial vessels with subsequent small-vessel collateralization. Dural arteriovenous fistulae (DAVFs) are most commonly noted after venous sinus or cortical vein thrombosis and are believed to be primarily due to venous hypertension and elevated sinus pressures, although there is no known association with moyamoya syndrome, or with surgical treatment for moyamoya disease (MMD). The authors present the case of a 14-year-old girl with Down syndrome treated using pial synangiosis for MMD who subsequently was noted to have bilateral DAVFs. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18603DOI Listing
April 2019
1 Read

Cerebral Venous Sinus Thrombosis with an Intracranial Haemorrhage: A Case Report.

Open Access Maced J Med Sci 2019 Mar 28;7(6):1029-1031. Epub 2019 Mar 28.

King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Department of Family Medicine, Jeddah, Saudi Arabia.

Background: Cerebral venous sinus thrombosis (CVST) is a rare, life-threatening disorder. It has an annual incidence of approximately two to four per million people per year. Nearly 70-80% of all cases of CVST are located in the superior sagittal sinus (SSS). Read More

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http://dx.doi.org/10.3889/oamjms.2019.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454179PMC
March 2019
1 Read

Incidence and features of thrombosis in children with inherited antithrombin deficiency.

Haematologica 2019 Apr 11. Epub 2019 Apr 11.

Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain;

Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). Read More

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http://dx.doi.org/10.3324/haematol.2018.210666DOI Listing
April 2019
1 Read

Acute Management of Ischemic Stroke During Pregnancy.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Departments of Obstetrics & Gynecology and Anesthesiology, the University of Texas Medical Branch at Galveston, Galveston, Texas.

Acute stroke in pregnancy can be devastating. Although neurologists will at some point be involved in the management, most of these patients are likely to first be evaluated by an obstetric care provider. It is, therefore, important for obstetric care providers to have an understanding of the presentation and management of stroke, particularly in the initial period when the window of opportunity for therapy is critical. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003220DOI Listing
April 2019
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Efficacy and Safety of Tranexamic Acid for Controlling Bleeding During Surgical Treatment of Intertrochanteric Fragility Fracture with Proximal Femoral Nail Anti-rotation: A Randomized Controlled Trial.

Indian J Orthop 2019 Mar-Apr;53(2):263-269

Department of Orthopaedic, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Background: Intertrochanteric fragility fracture (IFF) treated with proximal femoral nail anti-rotation (PFNA) is associated with significant hidden blood loss and high blood transfusion rate. The purpose of the present study was to evaluate the efficacy and safety of tranexamic acid (TXA) in reducing blood loss in these patients.

Materials And Methods: Consecutive eligible patients were recruited and randomly assigned to a TXA group or a control group. Read More

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http://dx.doi.org/10.4103/ortho.IJOrtho_401_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415572PMC
April 2019
1 Read

Cerebral Venous Sinus Incision for Surgical Thrombectomy Combined with Thrombolysis During Decompressive Craniectomy for Malignant Cerebral Venous Sinus Thrombosis Complicated with Cerebral Hernia.

J Stroke Cerebrovasc Dis 2019 Apr 5. Epub 2019 Apr 5.

Department of Neurosurgery, the People's Hospital of Jiaozuo, Jiaozuo, Henan, China.

For malignant cerebral venous sinus thrombosis (CVST) complicated with cerebral hernia, decompressive craniectomy may be life-saving, and thrombectomy combined with thrombolysis may obtain better outcomes. This report describes an approach performed on 2 patients diagnosed with CVST combined both thrombectomy and thrombolysis with decompressive craniectomy through incising the superior sagittal sinus. The general procedure of the operation is as follows. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.030DOI Listing
April 2019
1 Read

Signal Intensity within Cerebral Venous Sinuses on Synthetic MRI.

Magn Reson Med Sci 2019 Apr 5. Epub 2019 Apr 5.

Department of Radiology, Juntendo University School of Medicine.

Purpose: Flowing blood sometimes appears bright on synthetic T-weighted images, which could be misdiagnosed as a thrombus. This study aimed to investigate the frequency of hyperintensity within cerebral venous sinuses on synthetic MR images and to evaluate the influence of increasing flow rates on signal intensity using a flow phantom.

Materials And Methods: Imaging data, including synthetic and conventional MRI scans, from 22 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0144DOI Listing
April 2019
2 Reads
1.038 Impact Factor

Risk Factors and Prevalence of Deep Vein Thrombosis After the 2016 Kumamoto Earthquakes.

Circ J 2019 Apr 6. Epub 2019 Apr 6.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University.

Background: After previous earthquakes, a high prevalence of deep vein thrombosis (DVT) has been reported. We examined DVT prevalence and risk factors in evacuees of the Kumamoto earthquakes by performing mobile DVT screening at various evacuation centers around the epicenter. Methods and Results: For 1 month after the Kumamoto earthquake on 14 April 2016, mobile DVT screening using portable ultrasonography (US) was performed at 80 evacuation centers. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1369DOI Listing
April 2019
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Endovascular Thrombolysis or Thrombectomy for Cerebral Venous Thrombosis: Study of Nationwide Inpatient Sample 2004-2014.

J Stroke Cerebrovasc Dis 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, Academic Medical Center, Netherlands.

Background And Purpose: 15% of cerebral venous thrombosis (CVT) patients have poor outcomes despite anticoagulation. Uncontrolled studies suggest that endovascular approaches may benefit such patients. In this study, we analyze Nationwide Inpatient Sample (NIS) data to evaluate the safety and efficacy of endovascular therapy (ET) versus medical management in CVT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057193012
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.025DOI Listing
April 2019
2 Reads

Safety and Outcome of Intravenous Thrombolysis in Stroke Patients on Prophylactic Doses of Low Molecular Weight Heparins at Stroke Onset.

Stroke 2019 Apr 4:STROKEAHA118024575. Epub 2019 Apr 4.

From the Department of Clinical Neurosciences, Karolinska Institutet and Department of Neurology Karolinska University Hospital, Stockholm, Sweden (C.C., M.M., N.A.).

Background and Purpose- There are limited data on intravenous thrombolysis treatment in patients with ischemic stroke who have received prophylactic doses of low molecular weight heparins (LMWHs). We aimed to evaluate the safety and outcomes of intravenous thrombolysis treatment in stroke patients taking thromboprophylactic doses of LMWH. Methods- We analyzed 109 291patients treated with intravenous thrombolysis, recorded in the Safe Implementation of Treatments in Stroke International Thrombolysis Register between 2003 and 2017 not taking oral anticoagulants or therapeutic doses of heparin at stroke onset. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024575DOI Listing
April 2019
3 Reads

Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619832324

1 East Carolina University, Greenville, NC, USA.

Heparin-induced thrombocytopenia (HIT) type II is caused by antibody production that bind complexes between heparin and platelet factor 4 leading to platelet consumption and thrombosis. In a small subset of cases referred to as autoimmune HIT, the antibodies activate platelets even in the absence of heparin. Refractory HIT is a type of autoimmune HIT in which thrombocytopenia persists for weeks after heparin discontinuation and carries increased risk for thrombosis and more severe thrombocytopenia. Read More

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http://dx.doi.org/10.1177/2324709619832324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448115PMC
April 2019
2 Reads

The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?

Menopause 2019 Apr 1. Epub 2019 Apr 1.

Phoenix Veterans Administration Health Care System, Phoenix, AZ.

Objective: The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely menopausal hormone treatments (HT) on cardiovascular health and other effects of menopause after the premature termination of the Women's Health Initiative.

Method: The KEEPS was a randomized, double-blinded, placebo-controlled trial to test the hypothesis that initiation of HT (oral conjugated equine estrogens [o-CEE] or transdermal 17β-estradiol [t-E2]) in healthy, recently postmenopausal women (n = 727) would slow the progression of atherosclerosis as measured by changes in carotid artery intima-media thickness (CIMT).

Results: After 4 years, neither HT affected the rate of increase in CIMT. Read More

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http://dx.doi.org/10.1097/GME.0000000000001326DOI Listing
April 2019
3 Reads

Endovascular management of complex superior sagittal sinus dural arteriovenous fistula.

Neurosurg Focus 2019 Apr;46(Suppl_2):V11

Superior sagittal sinus (SSS) dural arteriovenous fistulas (DAVFs) are rare and present unique challenges to treatment. Complex, often bilateral, arterial supply and involvement of large volumes of eloquent cortical venous drainage may necessitate multimodality therapy such as endovascular, microsurgical, and stereotactic radiosurgery techniques. The authors present a complex SSS DAVF associated with an occluded/severely stenotic SSS. Read More

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http://dx.doi.org/10.3171/2019.2.FocusVid.18687DOI Listing
April 2019
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Cerebral Vasculitis in Ulcerative Colitis Is Predominantly Venular: Case Report and Review of the Literature.

Case Rep Rheumatol 2019 26;2019:9563874. Epub 2019 Feb 26.

Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

Extraintestinal complications of ulcerative colitis include isolated case reports of cerebral vasculitis. In this case report, we describe autopsy findings in a 50-year-old female who died as a result of massive multifocal cerebral hemorrhage. Microscopic examination of the left colon showed findings typical for ulcerative colitis. Read More

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http://dx.doi.org/10.1155/2019/9563874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413389PMC
February 2019
1 Read

Co-relation of Cerebral Venous Sinus Thrombosis with Vitamin B12 and Homocysteine Levels in a Tertiary Care Centre.

J Assoc Physicians India 2019 Jan;67(1):34-37

Dean, B.J. Government Medical, College, Pune and Sassoon General Hospitals, Pune, Maharashtra.

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January 2019
6 Reads

[Clinical analysis of cerebral venous sinus thrombosis in six children].

Zhonghua Er Ke Za Zhi 2019 Apr;57(4):277-280

Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To summarize the clinical features of cerebral venous sinus thrombosis (CVST) in 6 children, and to improve the understanding of CVST in children. The risk factors, clinical presentations, laboratory findings, imaging manifestations, treatments and outcomes of 6 children (3 males, 3 females) with CVST admitted to the Department of Pediatrics, First Affiliated Hospital of Zhengzhou University from January 2012 to December 2017 were analyzed retrospectively. The risk factors of disease were found in 5 cases, including 3 cases of infection, 1 case of L-asparaginase and dexamethasone chemotherapy and 1 case of oral prednisone alone. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.04.009DOI Listing
April 2019
1 Read

Eagle Syndrome as a Cause of Cerebral Venous Sinus Thrombosis.

Can J Neurol Sci 2019 Apr 1:1-2. Epub 2019 Apr 1.

Department of Neurology, Stroke Center, Neuroscience Center,The First Hospital of Jilin University,Changchun,China.

A 15-year-old teenager presented with a 2-month history of headache. Neurological examination was normal except for papilledema. Further lumbar puncture indicated intracranial hypertension (330 mm H2O). Read More

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http://dx.doi.org/10.1017/cjn.2019.17DOI Listing
April 2019
3 Reads

Prognosis of Cerebral Venous Sinus Thrombosis - Author Response.

Can J Neurol Sci 2019 Mar;46(2):265

Departments of Critical Care Medicine & Clinical Neurosciences,University of Calgary,Calgary, Alberta,Canada.

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http://dx.doi.org/10.1017/cjn.2018.393DOI Listing
March 2019
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A Case of Cerebral Venous Sinus Thrombosis Presenting During Relapse of Ulcerative Colitis.

Am J Case Rep 2019 Mar 31;20:419-422. Epub 2019 Mar 31.

Department of Gastroenterology, Oregon Health and Science University, Portland, OR, USA.

BACKGROUND Extra-intestinal manifestations of inflammatory bowel disease (IBD) include thromboembolic events that can present as deep vein thrombosis, pulmonary embolism, and cerebral venous sinus thrombosis. Cerebral venous sinus thrombosis is a rare complication of IBD that can be associated with high morbidity and mortality. This report is of a case of cerebral venous sinus thrombosis presenting in a young man during a relapse of ulcerative colitis (UC). Read More

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http://dx.doi.org/10.12659/AJCR.913429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454583PMC
March 2019
3 Reads

Hemorrhagic Transformation of Arterial Ischemic and Venous Stroke in Children.

Pediatr Neurol 2019 Feb 8. Epub 2019 Feb 8.

Division of Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Hemorrhagic transformation can complicate both arterial ischemic stroke and cerebral sinus venous thrombosis. Risk factors for hemorrhagic transformation after adult arterial ischemic stroke include larger infarct volume, cardioembolic stroke, and anticoagulation in the acute period. Large hemorrhagic transformation in adults is associated with poor outcome. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.023DOI Listing
February 2019
1 Read

Clinical efficacy of risk-stratified prophylaxis with low-dose aspirin for the management of symptomatic venous thromboembolism after total hip arthroplasty.

J Orthop Sci 2019 Mar 19. Epub 2019 Mar 19.

Shonan Kamakura Joint Reconstruction Center, 5-4-17 Dai, Kamakura, Kanagawa, 247-0061, Japan.

Background: Pulmonary thromboembolism (PTE) and deep vein thrombosis (DVT) are serious complications after total hip arthroplasty (THA). Aspirin has been considered a safe and cost-effective prophylaxis for venous thromboembolism (VTE), and there have been some reports about the incidence of PTE (0%-0.57%) and DVT (0. Read More

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http://dx.doi.org/10.1016/j.jos.2019.02.009DOI Listing
March 2019
1 Read

Surgical Superior Sagittal Sinus Thrombectomy in Refractory Thrombosis: A Technical Note.

Pediatr Neurosurg 2019 Mar 20:1-6. Epub 2019 Mar 20.

Division of Pediatric Neurosurgery, Department of Surgery, Sainte Justine Hospital, University of Montreal, Montreal, Québec, Canada,

Objective: Surgical treatment options are limited for medically and endovascular refractory cerebral venous sinus thrombosis (CVT). We describe the technical feasibility of open, direct sinus thrombectomy in a pediatric patient with medically and endovascular refractory CVT.

Methods: A 15-year-old patient with superior sagittal sinus (SSS) thrombosis refractory to medical and endovascular treatment experienced clinical deterioration with the progression of bifrontal hematomas and cerebral edema. Read More

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http://dx.doi.org/10.1159/000495808DOI Listing
March 2019
2 Reads
0.497 Impact Factor

Leading symptoms in cerebrovascular diseases: what about headache?

Neurol Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Neuroscience, Neurology and Stroke Unit, ASST GOM Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

Headache is a milestone in cerebrovascular disorders; indeed, it may represent the only symptom at onset or predominates over the other neurological features. Unfortunately, headache associated with cerebrovascular diseases lacks clear-cut characteristics as it may resemble a migraine attack, tension-type headache, or cluster headache; pain localization is also misleading along with drug (analgesic) response. However, in this review, we have analyzed and described the most common patterns of headache for different vascular disorders: it is known that headache due to subarachnoid aneurysmal hemorrhage presents peculiar characteristics (thunderclap, acute presentation, and high intensity), whereas in cerebral vasoconstriction syndrome, the short duration and the relapsing-remitting course of the thunderclap headache are key points for the diagnosis; in cervicocerebral artery, dissection pain is most commonly ipsilateral to the dissected vessel and is mainly perceived in the temporal area in case of carotid artery dissection and in the occipital area in case of vertebral artery dissection; in cerebral venous thrombosis, pain is often acute or subacute and severe; unfortunately, it may resemble a typical migraine attack or a tension-type episode; by the contrary, in primary angiitis of the central nervous system, pain is always subacute or chronic with mild-to-moderate intensity; finally, in brain arteriovenous shunts such as malformation or fistula, pain is more frequently a clue for disease complication such as hemorrhage from the malformation or thrombosis of the draining vein. Read More

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http://link.springer.com/10.1007/s10072-019-03793-8
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http://dx.doi.org/10.1007/s10072-019-03793-8DOI Listing
March 2019
4 Reads

Perinatal stroke syndromes: Similarities and diversities in aetiology, outcome and management.

Eur J Paediatr Neurol 2019 Feb 27. Epub 2019 Feb 27.

CHU Saint-Étienne, French Centre for Paediatric Stroke, Paediatric Physical and Rehabilitation Medicine Department, INSERM, CIC 1408, F-42055, Saint-Étienne, France; INSERM, U1059 Sainbiose, Univ Saint-Étienne, Univ Lyon, F-42023, Saint-Étienne, France. Electronic address:

With a birth-prevalence of 37-67/100,000 (mostly term-born), perinatal stroke encompasses distinct disease-states with diverse causality, mechanism, time of onset, mode of presentation and outcome. Neonatal primary haemorrhagic stroke and ischemic events (also divided into neonatal arterial ischemic stroke and neonatal cerebral sinus venous thrombosis) that manifest soon after birth are distinguished from presumed perinatal - ischemic or haemorrhagic - stroke. Signs of the latter become apparent only beyond the neonatal period, most often with motor asymmetry or milestones delay, and occasionally with seizures. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.02.013DOI Listing
February 2019
1 Read

The Thunderclap Headache: Approach and Management in the Emergency Department.

J Emerg Med 2019 Mar 14. Epub 2019 Mar 14.

Department of Emergency Medicine, Brooke Army Military Medical Center, Fort Sam Houston, Texas.

Background: A thunderclap headache (TCH) is a severe headache reaching at least 7 (out of 10) in intensity within 1 min of onset, and can be the presenting symptom of several conditions with potential for significant morbidity and mortality.

Objective Of The Review: This narrative review evaluates the various conditions that may present with TCH and proposes a diagnostic algorithm for patients with TCH.

Discussion: TCH is a symptom associated with several significant diseases. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.01.026DOI Listing
March 2019
7 Reads

Sotos Syndrome Presenting with Neonatal Hyperinsulinaemic Hypoglycaemia, Extensive Thrombosis, and Multisystem Involvement.

Horm Res Paediatr 2019 Mar 15:1-7. Epub 2019 Mar 15.

Department of Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Initially described as an uncommon presenting feature of Sotos syndrome (SoS), over the last decades, congenital hyperinsulinaemic hypoglycaemia (CHI) has been increasingly reported in association with this condition. The mechanism responsible for CHI in SoS is unclear. We report the case of a neonate presenting with CHI and extensive venous and arterial thrombosis associated with kidney, heart, liver, skeleton, and brain abnormalities and finally diagnosed with SoS on whole genome sequencing. Read More

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http://dx.doi.org/10.1159/000496545DOI Listing
March 2019
2 Reads

Infratentorial Developmental Venous Abnormalities and Inflammation Increase Odds of Sporadic Cavernous Malformation.

J Stroke Cerebrovasc Dis 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Goal: Sporadic brain cavernous malformations commonly correlate with developmental venous anomalies; however, developmental venous anomalies may exist without cavernous malformations. Infratentorial location and specific angioarchitectural features of the developmental venous anomaly increase the odds of a concomitant malformation. Animal data also suggest chronic inflammatory disease, oxidative stress, and angiogenesis promote cavernous malformation development. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.025DOI Listing

Clinical use of Tc-HMPAO-labeled platelets in cerebral sinus thrombosis imaging.

Acta Neurol Belg 2019 Mar 13. Epub 2019 Mar 13.

Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, 1419731351, Iran.

Magnetic resonance imaging (MRI) and computed tomography (CT) are not always conclusive for the detection of cerebral venous sinus thrombosis (CVST). Tc-HMPAO-labeled platelets may be useful in cases with high clinical suspicion. Three patients with headaches with or without intraparenchymal hemorrhage that were highly suspected to have CVST, despite inconclusive anatomical imaging, were selected for inclusion in the study. Read More

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http://dx.doi.org/10.1007/s13760-019-01107-5DOI Listing
March 2019
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Predictors of Successful Discharge of Patients on Postoperative Day 1 After Craniotomy for Brain Tumor.

World Neurosurg 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurological Surgery, University of Miami, Miami, Florida, USA.

Background: Shorter hospital stays have been associated with decreased complication rates, fewer hospital-acquired infections, and lower costs. We evaluated an optimized treatment paradigm for patients undergoing craniotomy allowing for postoperative day 1 (POD1) discharge if the criteria were met. We compared the complication and readmission rates between the POD1 patients and those with longer stays, and examined the patient and surgical variables for predictors of POD1 discharge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193061
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http://dx.doi.org/10.1016/j.wneu.2019.03.004DOI Listing
March 2019
6 Reads

PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design.

Thromb Haemost 2019 Mar 12. Epub 2019 Mar 12.

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States.

Venous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute to significant long-term sequelae. The PREVAPIX-ALL study is an open-label randomized controlled study comparing outcomes of treatment with prophylactic dose apixaban versus no anticoagulation (standard of care) in children and adolescents with ALL and T/B cell LL receiving standard induction chemotherapy with asparaginase and the presence of a central venous access device. On day 29 of induction, all patients undergo screening imaging with duplex ultrasonography and echocardiography. Read More

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http://dx.doi.org/10.1055/s-0039-1679938DOI Listing
March 2019
3 Reads

Hemorrhagic stroke complicated by cerebral venous sinus thrombosis with idarucizumab.

Neurol Clin Pract 2019 Feb;9(1):e4-e6

Departments of Neurology (CSP, HC) and Radiology (AB), Campbelltown Hospital; and School of Medicine (CSP, HC), University of Western Sydney, Campbelltown, Australia.

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http://dx.doi.org/10.1212/CPJ.0000000000000555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382382PMC
February 2019
1 Read

Neurological complications in childhood nephrotic syndrome: A systematic review.

Eur J Paediatr Neurol 2019 Feb 22. Epub 2019 Feb 22.

1st Department of Paediatrics, Aristotle University of Thessaloniki, "Hippokratio" General Hospital, Thessaloniki, Greece.

Background And Objective: Nephrotic syndrome (NS) in childhood can be accompanied by serious neurological complications increasing the morbidity of disease. The study aimed to assess the spectrum of neurological complications in children with in terms of clinical presentation, contributory risk factors, and outcome.

Methods: In this systematic review, we searched for articles in PubMed, providing individual patient-level data for any neurological complication in children and adolescents with primary NS, between January 1, 1990 and April 30, 2018. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.02.007DOI Listing
February 2019
4 Reads

No evidence of increased cerebrovascular involvement in adult neurologically-asymptomatic β-Thalassaemia. A multicentre multimodal magnetic resonance study.

Br J Haematol 2019 Mar 5. Epub 2019 Mar 5.

Dipartimento di Medicina e Chirurgia, Scuola Medica Salernitana, Sezione di Neuroscienze, Università di Salerno, Salerno, Italy.

Multi-factorial causes jeopardize brain integrity in β-thalassaemia. Intracranial parenchymal and vascular changes have been reported among young β-thalassaemia patients but conventional magnetic resonance imaging (MRI) findings are contradictory making early MRI and magnetic resonance angiography (MRA)/venography monitoring a matter of debate. This study prospectively investigated 75 neurologically asymptomatic β-thalassaemia patients (mean-age 35·2 ± 10·7 years; 52/75 transfusion-dependent; 41/75 splenectomised) using a 3T magnetic resonance scanner; clinical, laboratory and treatment data were also collected. Read More

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http://dx.doi.org/10.1111/bjh.15834DOI Listing
March 2019
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Safety and efficacy of intravascular ultrasound as an adjunct to stenting for cerebral venous sinus stenosis-induced idiopathic intracranial hypertension: a pilot study.

J Neurosurg 2019 Mar 1:1-6. Epub 2019 Mar 1.

Departments of1Neurosurgery.

OBJECTIVESymptomatic intracranial hypertension can be caused by cerebral venous sinus stenosis (CVSS) and cerebral venous sinus thrombotic (CVST) stenosis, which is usually found in some patients with idiopathic intracranial hypertension (IIH). Recently, at the authors' center, they utilized intravascular ultrasound (IVUS) as an adjunct to conventional venoplasty or stenting to facilitate diagnosis and accurate stent placement in CVSS.METHODSThe authors designed a retrospective review of their prospective database of patients who underwent IVUS-guided venous sinus stenting between April 2016 and February 2017. Read More

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http://dx.doi.org/10.3171/2018.11.JNS181885DOI Listing
March 2019
3 Reads

Cerebral Venous Sinus Thrombosis in Mid-South USA.

Can J Neurol Sci 2019 Mar 4;46(2):264. Epub 2019 Mar 4.

Division of Critical Care, Department of Anesthesiology,Vanderbilt University Medical Center,Nashville, TN,USA.

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http://dx.doi.org/10.1017/cjn.2018.392DOI Listing
March 2019
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[Incidence and risk factor analysis of deep venous thrombosis in patients with severe traumatic brain injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Feb;31(2):182-186

Department of ICU, the First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei 230009, Anhui, China.

Objective: To estimate the incidence and risk factors for deep venous thrombosis (DVT) in patients with severe traumatic brain injury (TBI) treated in the intensive care unit (ICU).

Methods: 105 patients with TBI admitted to the First Affiliated Hospital of University of Science and Technology of China from January 2016 to June 2018 were enrolled [Glasgow coma scale (GCS) 3-8; concise injury score for other parts ≤ 3]. All patients did not receive any medication or physical measures to prevent DVT during hospitalization. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.02.012DOI Listing
February 2019
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Elevated Factor VIII Level Associated with Transverse Cerebral Venous Sinus Thrombosis.

Am J Case Rep 2019 Mar 2;20:274-277. Epub 2019 Mar 2.

Department of Medicine, Charleston Area Medical Center, Charleston, WV, USA.

BACKGROUND Cerebral venous sinus thrombosis (CVST) is an uncommon cause of stroke. CVST can be caused by systemic conditions as well as mechanical factors that reduce blood flow to promote thrombosis. These can include hormonal therapies, pregnancy, malignancy, genetic conditions. Read More

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http://dx.doi.org/10.12659/AJCR.913917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410610PMC
March 2019
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Neurologic Complications of Sickle Cell Disease.

Curr Neurol Neurosci Rep 2019 Feb 28;19(4):17. Epub 2019 Feb 28.

Department of Neurology, University of Illinois at Chicago College of Medicine, 912 S Wood Street, Suite 164C, Chicago, IL, USA.

Purpose Of Review: Sickle cell anemia is a multiorgan disease with acute and chronic complications. Involvement of the central nervous system (CNS) is associated with increased mortality and morbidity. This review highlights the broad spectrum of neurological complications seen in patients with sickle cell disease. Read More

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http://dx.doi.org/10.1007/s11910-019-0932-0DOI Listing
February 2019
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Updated Imaging Findings in Congenital Zika Syndrome: A Disease Story That is Still Being Written.

Top Magn Reson Imaging 2019 Feb;28(1):1-14

Royal Perth Hospital (RPH).

In congenital Zika virus syndrome (CZS), the most frequent radiological findings are calcifications in the cortical-white matter junction and malformations of cortical development (pachygyria or polymicrogyria, which occur predominantly in the frontal lobes, or a simplified gyral pattern), ventriculomegaly, enlargement of the cisterna magna and the extra-axial subarachnoid space, corpus callosum abnormalities, and reduced brain volume. This syndrome can also result in a decrease in the brainstem and cerebellum volumes and delayed myelination. Infants with CZS may show venous thrombosis and lenticulostriate vasculopathies. Read More

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http://dx.doi.org/10.1097/RMR.0000000000000193DOI Listing
February 2019
3 Reads

Therapeutic strategies of thromboembolic events in patients with inflammatory bowel diseases: Two case reports.

Medicine (Baltimore) 2019 Mar;98(9):e14622

Department of Gastroenterology, Jiangsu Province Hospital of Chinese Medicine (Affiliated Hospital of Nanjing University of Chinese Medicine), Nanjing, China.

Rationale: Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammatory condition and immunological abnormalities, which probably develop into venous thromboembolic events (VTEs). VTE in IBD patients mostly occurs at deep venous thrombosis (DVT) and pulmonary embolism (PE). The complications are extremely important in clinical practice considering the high mortality rate. Read More

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http://dx.doi.org/10.1097/MD.0000000000014622DOI Listing
March 2019
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Inflammatory markers are beneficial in the early stages of cerebral venous thrombosis.

Arq Neuropsiquiatr 2019 Feb;77(2):101-105

Sakarya Universitesi, Egitim ve Arastirma Hastanesi, Noroloji Kliniği, Sakarya, Turkey.

Background: Cerebral vein thrombosis (CVT) is a rare but serious cause of acute stroke. Inflammation is a hypothetical etiological factor in CVT.

Objective: The aim of this study was to evaluate inflammatory marker levels in CVT patients and compare these with healthy individuals. Read More

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http://dx.doi.org/10.1590/0004-282X20190001DOI Listing
February 2019

Multimodal Regional Brain Monitoring of Tissue Ischemia in Severe Cerebral Venous Sinus Thrombosis.

Neurocrit Care 2019 Feb 25. Epub 2019 Feb 25.

Department of Intensive Care Medicine, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Background: Comatose critically ill patients with severe diffuse cerebral venous thrombosis (CVT) are at high risk of secondary hypoxic/ischemic insults, which may considerably worsen neurological recovery. Multimodal brain monitoring (MBM) may therefore improve patient care in this setting, yet no data are available in the literature.

Methods: We report two patients with coma following severe diffuse CVT who underwent emergent invasive MBM with intracranial pressure (ICP), brain tissue oximetry (PbtO), and cerebral microdialysis (CMD). Read More

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http://dx.doi.org/10.1007/s12028-019-00695-7DOI Listing
February 2019
1 Read