8,682 results match your criteria Cerebral Venous Thrombosis


Cerebrovascular intervention therapy worked positively in one patient with severe cerebral venous sinus thrombosis due to hyperthyroidism: a case report and review of the literature.

J Med Case Rep 2022 Jun 26;16(1):250. Epub 2022 Jun 26.

Department of Neurology, Shanghai Xuhui District Central Hospital, 966 Middle Huaihai Road, Xuhui District, Shanghai, China.

Background: With further understanding of cerebral venous sinus thrombosis, hyperthyroidism has gradually been revealed as a rare predisposing factor for cerebral venous sinus thrombosis, which may present as more compact clots and resistance to fibrinolysis, also known as a predictor of worse outcomes. For patients with severe cerebral venous sinus thrombosis, proper treatment method should be initiated as soon as possible since they may deteriorate rapidly.

Case Presentation: In this case report, we present a 32-year-old Mongoloid woman admitted with progressive headache, impaired consciousness, and right limb weakness, diagnosed with cerebral venous sinus thrombosis caused by hyperthyroidism. Read More

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Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review.

J Neurol Sci 2022 Jun 20;439:120327. Epub 2022 Jun 20.

Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, CA, USA. Electronic address:

Introduction: One of the rare but potentially serious side effects of COVID-19 vaccination is arterial and venous thrombosis. Acute ischemic stroke (AIS) cases have been reported post COVID-19 vaccination. Herein, we systematically reviewed the reported cases of AIS after COVID-19 vaccination. Read More

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COVID-19-associated Isolated Cortical Vein Thrombosis: Detection of SARS-CoV-2 in CSF.

Neurohospitalist 2022 Jul 4;12(3):520-523. Epub 2022 Mar 4.

Neurology Department, Haseki Research and Training Hospital, University of Health Science, Istanbul, Turkey.

COVID-19 has been associated with central nervous system manifestations; however, cerebral venous thrombosis is rarely reported. A 34-year-old woman was admitted to the hospital with headache and recurrent seizures; she was recently discharged after COVID-19 pneumonia. Cranial magnetic resonance imaging and magnetic resonance venography showed cortical vein thrombosis in the right frontal lobe. Read More

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Comprehensive Thrombophilia Evaluation in Cerebral Venous Thrombosis: A Single Center Cross Sectional Study.

Indian J Hematol Blood Transfus 2022 Jul 14;38(3):522-528. Epub 2021 Aug 14.

Internal Medicine, INHS Asvini, Mumbai, India.

In patients with Cerebral Venous Thrombosis (CVT), inherited and acquired thrombophilic conditions have been studied either individually or as subset of a comprehensive evaluation. None of the studies have included a comprehensive evaluation of all the known associations. The associations for various conditions have been found to differ significantly between the Indian and the Western population. Read More

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Clinical Observation and Value Analysis of Endovascular Interventional Therapy for Intracranial Venous Sinus Thrombosis.

Biomed Res Int 2022 14;2022:4931210. Epub 2022 Jun 14.

Department of Neurosurgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.

The main aim of this study was to investigate the therapeutic effect of endovascular interventional therapy on cerebral venous sinus thrombosis (CVST). 137 patients with CVST were included, 92 patients were treated with interventional therapy, and 45 patients were treated with conventional anticoagulant therapy. Through endovascular therapy (EVT) combined with therapy, the patients were treated with EVT in combination with conventional anticoagulant therapy, and the prognosis of the two groups of patients was evaluated. Read More

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Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.

Biomedicines 2022 Jun 1;10(6). Epub 2022 Jun 1.

Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Read More

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Drag-out technique using a large balloon fixed with an aspiration catheter for retrieving residual thrombus on the wall of the superior sagittal sinus: illustrative case.

J Neurosurg Case Lessons 2022 May 23;3(21):CASE22116. Epub 2022 May 23.

Department of Neurosurgery, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan.

Background: The authors report a patient with sagittal sinus thrombosis that was resistant to reported endovascular treatments but successfully recanalized by dragging out the thrombus using a large balloon fixed with an aspiration catheter.

Observations: A 57-year-old man presented with the persistent headache and a simple partial seizure. Diagnostic study with computed tomography and angiography demonstrated the superior sagittal sinus (SSS) thrombosis. Read More

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Intracranial complications of hypercoagulability and superinfection in the setting of COVID-19: illustrative cases.

J Neurosurg Case Lessons 2022 May 23;3(21):CASE22127. Epub 2022 May 23.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Hypercoagulability with thrombosis and associated inflammation has been well-documented in COVID-19, and catastrophic cerebral venous sinus thromboses (CVSTs) have been described. Another COVID-19-related complication is bacterial superinfection, including sinusitis. Here, the authors reported three cases of COVID-19-associated sinusitis, meningitis, and CVST and summarized the literature about septic intracranial thrombotic events as a cause of headache and fever in COVID-19. Read More

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Neurological Manifestations of Scrub Typhus.

Curr Neurol Neurosci Rep 2022 Jun 21. Epub 2022 Jun 21.

Department of Neurology, Vivekananda Institute of Medical Science, Kolkata, India.

Purpose Of Review: The occurrence of cases of scrub typhus is on the rise in South Asian and Southeast Asian countries. The present review discusses neurological complications following scrub typhus to appraise clinicians practicing in endemic regions about considering this treatable disease in the differential diagnosis of acute febrile illnesses, especially when accompanied with clinical neurological features.

Recent Findings: While the association of aseptic meningitis, encephalitis, and meningoencephalitis with scrub typhus is well known, more recently described neurological syndromes associated with scrub typhus include acute disseminated encephalomyelitis, various cranial nerve palsies, cerebellitis, cerebrovascular diseases including cerebral venous sinus thrombosis, transverse myelitis, longitudinally extensive transverse myelitis, Guillain-Barré syndrome, opsoclonus-myoclonus syndrome, parkinsonism, and many more. Read More

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Comparison of susceptibility-weighted angiography (SWAN) and T2 gradient-echo sequences for the detection of acute cerebral venous thrombosis.

Neuroradiol J 2022 Jun 18:19714009221109885. Epub 2022 Jun 18.

Department of Radiology, Bichat Hospital, 55076Assistance Publique-Hôpitaux de Paris, Paris, France.

Objectives: To assess the diagnostic accuracy and lesion conspicuity of susceptibility-weighted angiography (SWAN) and T2* for the clot detection in acute cerebral venous thrombosis (CVT) by comparison with contrast-enhanced MR venography.

Methods: Venous thrombi detection and conspicuity were assessed by two readers for 18 venous segments on both T2*, SWAN source images, 2D SWAN reformats matching with T2*, and 3D SWAN images (SWAN-MinIP). Images obtained with the three reading techniques were systematically scored and compared to CE MRV findings, in a blinded fashion, per patient and per segment, and compared to each other. Read More

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[Prevalence and etiological profiles of atypical localization venous thrombosis : A descriptive multicenter study].

Ann Cardiol Angeiol (Paris) 2022 Jun 16. Epub 2022 Jun 16.

Service de Médecine Interne, Centre hospitalier Universitaire Joseph Raseta Befelatanana, Antananarivo, Madagascar.

Introduction: Venous thrombosis of unusual sites is much rarer than in the lower limbs and requires a rigorous etiological approach. The objective was to describe the clinical and progressive peculiarities of unusual localization venous thrombosis as well as their etiologies.

Patients And Methods: Multicenter descriptive retrospective study of hospitalized patient records in the two large Hospital Centers, Antananarivo, Madagascar between 2017 and 2020 in which the diagnosis of unusual venous thrombosis was confirmed by imaging. Read More

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Bilateral parafalcine cortical and leptomeningeal impairment in MOG antibody disease and AQP4 neuromyelitis optica.

J Neuroimmunol 2022 May 20;369:577898. Epub 2022 May 20.

Department of Neurology, the First Medical Centre of Chinese PLA General Hospital, Beijing 100853, China. Electronic address:

Objective: Bilateral parafalcine cortical and leptomeningeal impairment (BPCLI) is a rare finding observed in cases of myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOGAD) and neuromyelitis optica spectrum disorders (NMOSD). The failure to recognize BPCLI may lead to misdiagnosis and delayed treatment. This study aimed to delineate the clinical and imaging characteristics of patients with BPCLI. Read More

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A Rare Case of Extensive Cerebral Venous Sinus Thrombosis Complicated by Heparin-Induced Thrombocytopenia.

Case Rep Hematol 2022 6;2022:7845786. Epub 2022 Jun 6.

Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25701, USA.

Cerebral venous sinus thrombosis (CVST) is a rare but potentially life-threatening cause of stroke. Several risk factors have been identified including hypercoagulable state, malignancy, use of oral contraceptives, pregnancy, head injury, infection, and prothrombotic states such as heparin-induced thrombocytopenia (HIT). HIT is a prothrombotic state leading to thrombosis in several distinct locations including CVST requiring prompt discontinuation of heparin and initiation of nonheparin anticoagulation to prevent catastrophic consequences. Read More

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Susceptibility Weighted Imaging: An Effective Auxiliary Sequence That Enhances Insight Into the Imaging of Stroke.

Cureus 2022 May 11;14(5):e24918. Epub 2022 May 11.

Department of Radiology, Dr. D Y Patil Medical College, Hospital and Research Centre, Pune, IND.

Aim: To evaluate the utility of susceptibility-weighted imaging (SWI) sequence in stroke imaging and assess supplemental information provided by SWI in an acute stroke scenario.

Materials And Methods: In this study, the appearance of cerebrovascular stroke on the SWI images were analyzed in 50 patients who presented with acute-onset neurological symptoms.

Results: Brain MRI with SWI was performed on 50 patients presenting with acute neurological symptoms. Read More

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Analysis of Thromboembolic and Thrombocytopenic Events After the AZD1222, BNT162b2, and MRNA-1273 COVID-19 Vaccines in 3 Nordic Countries.

JAMA Netw Open 2022 Jun 1;5(6):e2217375. Epub 2022 Jun 1.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Importance: Vaccinations are paramount to halt the COVID-19 pandemic, and safety data are essential to determine the risk-benefit ratio of each COVID-19 vaccine.

Objective: To evaluate the association between the AZD1222, BNT162b2, and mRNA-1273 vaccines and subsequent thromboembolic and thrombocytopenic events.

Design, Setting, And Participants: This self-controlled case series used individual-level data from national registries in Norway, Finland, and Denmark. Read More

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Thrombus Distribution in Vaccine-induced Immune Thrombotic Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.

Radiology 2022 Jun 14:220365. Epub 2022 Jun 14.

Centre for Medical Imaging, University College London.

This case series reports 40 patients (median age, 41 years [interquartile range (IQR) 32- 52, 22 men) with confirmed vaccine-induced immune thrombotic thrombocytopaenia after administration of their first ChAdOx1 nCov-19 (AstraZeneca) vaccine: 80% (n=32) developed symptoms within the first 14 days and 20% (n=8) within 14-28 days. The location and extent of thrombi were evaluated using CT, MRI and ultrasound. Of the 40, 73% (n=29) presented with neurological symptoms and had confirmed cerebral venous sinus thrombosis, 30% (n=12) had extension of their primary thrombus, and 20% (n=8) died. Read More

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Double Trouble: A Case of Two Simultaneous Thrombotic Events in a Patient With COVID-19.

Cureus 2022 May 11;14(5):e24912. Epub 2022 May 11.

Internal Medicine, Nassau University Medical Center, East Meadow, USA.

Coronavirus disease 2019 (COVID-19) is known to primarily have respiratory tract involvement, but thromboembolic complications can occur as well, leading to increased overall mortality seen in these patients. We present a case of a patient infected with COVID-19 who then developed two simultaneous thrombotic events. Our patient is a 57-year-old male who presented to the emergency department with sudden onset dysarthria and left lower extremity weakness. Read More

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Neurological Predictors of Functional Outcome in Cortical Venous Sinus Thrombosis.

J Neurosci Rural Pract 2022 Apr 10;13(2):290-294. Epub 2022 Mar 10.

Department of Critical Care Medicine, Dayanand Medical College and Hospital, Ludhiana, India.

 Cerebral venous sinus thrombosis (CVST) has a wide clinical spectrum. Despite favorable prognosis, identifying CVST patients with a possible poor functional outcome can be challenging. This study aims to establish the neurological predictors of outcome in CVST. Read More

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Recanalisation and Outcome in Cerebral Venous-sinus Thrombosis.

Authors:
D Nagaraja

Ann Indian Acad Neurol 2022 Mar-Apr;25(2):177-178. Epub 2022 Mar 1.

Director-DIMHANS and Director and Vice Chancellor, National Institute of Former Mental Health and Neurosciences (NIMHANS)-Deemed University, Bangalore, Karnataka, India.

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Clinical Characteristics, Etiology, Recanalization Rates and Neurological Outcomes in CVT: A Prospective Cohort Study.

Ann Indian Acad Neurol 2022 Mar-Apr;25(2):229-234. Epub 2022 Feb 8.

Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.

Background: Recanalization rates in cerebral venous thrombosis (CVT) and its effect on neurological outcome have been debated worldwide and are inadequately addressed in studies from India. Our objective was to study the clinical profile of CVT and determine recanalization rates with its predictors and its effect on outcome.

Methods: A prospective single centre cohort study on 101 patients with radiologically confirmed acute CVT between October 2018 and June 2021 was conducted. Read More

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February 2022

Cerebral venous sinus thrombosis in COVID 19 patients: Report of 2 cases.

Interdiscip Neurosurg 2022 Sep 6;29:101599. Epub 2022 Jun 6.

Department of Neurosurgery, Zagazig University, Zagazig, Egypt.

Background: Initially, novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) was considered primarily a respiratory pathogen. However, with time it has behaved as a virus with the potential to cause multi-system involvement, including neurological manifestations which varies from acute to subacute onset of headache, seizures, a decrease of consciousness, and paralysis.

Case Description: Two cases of cerebral sinus venous thrombosis in COVID-19 patients were reported, following respiratory disorders, which was triggered by the SARS-CoV-2 infection. Read More

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September 2022

Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination.

Ann Neurol 2022 Jun 10. Epub 2022 Jun 10.

Department of Critical Care, Annecy Genevois Hospital, Annecy, France.

Objective: Cerebral venous thrombosis caused by vaccine-induced immune thrombotic thrombocytopenia (VITT-CVT) is a rare adverse effect of adenovirus-based SARS-CoV-2 vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. Read More

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Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis.

J Neuroinflammation 2022 Jun 10;19(1):137. Epub 2022 Jun 10.

Department of Cerebrovascular Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.

Background: Neuroinflammation-induced injury is intimately associated with poor prognosis in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) axis is a cytoplasmic double-stranded DNA (dsDNA) sensing pathway has recently emerged as a crucial mediator of neuroinflammation in ischemic stroke. However, the role of the cGAS-STING pathway in modulating post-CVST inflammation and the underlying mechanisms involved remain unclear. Read More

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Neurocritical Care Performance Measures Derived from Electronic Health Record Data are Feasible and Reveal Site-Specific Variation: A CHoRUS Pilot Project.

Neurocrit Care 2022 Jun 10. Epub 2022 Jun 10.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Background: We evaluated the feasibility and discriminability of recently proposed Clinical Performance Measures for Neurocritical Care (Neurocritical Care Society) and Quality Indicators for Traumatic Brain Injury (Collaborative European NeuroTrauma Effectiveness Research in TBI; CENTER-TBI) extracted from electronic health record (EHR) flowsheet data.

Methods: At three centers within the Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AI consortium, we examined consecutive neurocritical care admissions exceeding 24 h (03/2015-02/2020) and evaluated the feasibility, discriminability, and site-specific variation of five clinical performance measures and quality indicators: (1) intracranial pressure (ICP) monitoring (ICPM) within 24 h when indicated, (2) ICPM latency when initiated within 24 h, (3) frequency of nurse-documented neurologic assessments, (4) intermittent pneumatic compression device (IPCd) initiation within 24 h, and (5) latency to IPCd application. We additionally explored associations between delayed IPCd initiation and codes for venous thromboembolism documented using the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) system. Read More

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Adverse Events and All-Cause Mortality in Danish Patients with Cerebral Venous Thrombosis: A Nationwide Cohort Study.

Thromb Haemost 2022 Jun 10. Epub 2022 Jun 10.

Unit for Thrombosis and Drug Research, Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

Background:  Cerebral venous thrombosis (CVT) is a rare manifestation of stroke and venous thromboembolism (VTE), compared with deep vein thrombosis (DVT) and pulmonary embolism (PE). We examined whether CVT was associated with adverse cardiovascular events.

Methods:  A Danish cohort study with adult patients diagnosed with CVT ( = 1,015) between 1997 and 2017. Read More

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Endovascular and Medical Management of Cerebral Venous Thrombosis: A Systematic Review and Network Meta-Analysis.

World Neurosurg 2022 Jun 7. Epub 2022 Jun 7.

Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Champaign, IL; Department of Neurosurgery, Carle Foundation Hospital, Urbana, IL. Electronic address:

Introduction: Management of cerebral venous thrombosis (CVT) involves minimizing expansion of the thrombus and promoting the recanalization of the venous sinus. While current guidelines include indications of endovascular management, and anticoagulation with heparin and warfarin, the use of direct oral anticoagulants (DOACs) has increased. In this study, we aim to conduct a network meta-analysis comparing these three therapeutic options: standard anticoagulation, DOACs, and endovascular treatments (EVTs). Read More

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Meaningful use of imaging resources to rule out cerebral venous sinus thrombosis after ChAdOx1 COVID-19 vaccination: Evaluation of the AHA diagnostic algorithm with a clinical cohort and a systematic data review.

J Clin Neurosci 2022 Jun 6;102:5-12. Epub 2022 Jun 6.

Department of Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University Cologne, Cologne, Germany. Electronic address:

Vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous thrombosis (CVST) is an improbable (0.0005%), however potentially lethal complication after ChAdOx1 vaccination. On the other hand, headache is among the most frequent side effects of ChAdOx1 (29. Read More

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Superior Vena Cava Syndrome Due to Thrombosis: A Case Report.

Cureus 2022 May 7;14(5):e24811. Epub 2022 May 7.

Pulmonary and Critical Care, Richmond University Medical Center, Staten Island, USA.

Superior vena cava (SVC) syndrome is a clinical entity with signs and symptoms resulting from obstruction of blood flow through the SVC. The resulting obstruction leads to edema in the upper body, including the head, neck, and upper extremities. Clinical signs and symptoms can include plethora, cyanosis, dyspnea, stridor, cough, and hoarseness, as well as more serious complications such as cerebral edema leading to headache, confusion, and coma. Read More

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Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality.

J Stroke 2022 05 31;24(2):256-265. Epub 2022 May 31.

Division de Neurologia Vascular, Departmento de Neurologia, Institute for Neurological Research - FLENI, Buenos Aires, Argentina.

Background And Purpose: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year.

Methods: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. Read More

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Safety and efficacy comparison between OACs plus single antiplatelet and dual antiplatelet therapy in patients with cerebral venous sinus stenosis poststenting.

BMC Neurol 2022 Jun 6;22(1):209. Epub 2022 Jun 6.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Background And Purpose: The present strategies regarding poststent management for cerebral venous sinus stenosis (CVSS) are inconsistent. Herein, we compared the safety and efficacy of oral anticoagulants (OACs) plus single antiplatelet therapy and dual antiplatelet therapy for CVSS poststenting.

Methods: A real-world observational study conducted from January 2009 through October 2019 enrolled patients who were diagnosed with CVSS and received stenting. Read More

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