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Dev Med Child Neurol 2022 May 21. Epub 2022 May 21.

Oslo University Hospital - Department of Clinical Neurosciences for Children, Oslo, Norway.

Taiwan J Obstet Gynecol 2022 May;61(3):544-550

Center for Reproductive Medicine and Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, 130021, China; Jilin Engineering Research Center for Reproductive Medicine and Genetics, Jilin University, Changchun, 130021, China. Electronic address:

Objective: Chromosome 16p11.2 deletions have been recognized as a genetic disorder with well-described postnatal phenotypes. However, the prenatal manifestations are atypical for lacking of enough evidence. Read More

Dev Neurosci 2022 May 19. Epub 2022 May 19.

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal morbidity and mortality worldwide. Approximately 1 million infants born with HIE each year survive with cerebral palsy (CP) and/or serious cognitive disabilities. While infants born with mild and severe HIE frequently result in predictable outcomes, infants born with moderate HIE exhibit variable outcomes that are highly unpredictable. Read More

PLoS One 2022 19;17(5):e0268108. Epub 2022 May 19.

Université Paris Cité, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Paris, France.

Aim: To study the association between the socioeconomic environment of area of residence and prevalence and characteristics of children with cerebral palsy (CP).

Method: Data on 8-year-old children with CP born in 2000-2011 (n = 252) were extracted from a regional population-based register in France. The European Deprivation Index (EDI), available at census block level, characterised socioeconomic deprivation in the child's area of residence at age of registration. Read More

Proc North Cent Sect 2022 18;2022. Epub 2022 Mar 18.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.

A contemporary issue for many non-profits is identifying effective ways to build capacity for service delivery. Interdisciplinary processes take time to carry out; herein lies a challenge when working with a university in which the lifecycle of student activity is not aligned (much shorter) that of the project for the alternative education program. In the current work, we describe the pathway of a partnership that improves the ability of nonprofit staff to achieve their mission while simultaneously meeting the service motivation in an academic setting. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):616-621

Istanbul University, Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation - Istanbul, Turkey.

Objective: This study aimed to investigate the effect of an adaptive seating system on pelvic obliquity and spinal coronal/sagittal balance in children with nonambulatory cerebral palsy and scoliosis.

Methods: This was a single-blind, prospective, randomized interventional study. Nonambulatory children aged 6-15 years with cerebral palsy and scoliosis were included. Read More

J Intellect Disabil 2022 May 18:17446295221095712. Epub 2022 May 18.

Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy.

Increased attention is arising on the delivery of remote cognitive interventions, which allow performing exercises in everyday settings, favouring rehabilitation continuity. The present study offers an overview of remote cognitive training programs for children with congenital brain malformation or genetic syndrome affecting the central nervous system, included in papers published in the time period 2011-2021. A total of 13 records was found and discussed including efficacy studies, feasibility studies and study protocols. Read More

J Exerc Rehabil 2022 Apr 26;18(2):96-103. Epub 2022 Apr 26.

Department of Physical Therapy, College of Nursing and Healthcare Science, Dong-Eui University, Busan, Korea.

This study determined the effectiveness of 16 multisensory storytelling sessions on physical function and activity participation in children with cerebral palsy. Twenty-four children aged 7 to 8 who belonged to stage I to III of the Gross Motor Function Classification System were randomly divided into experimental and control groups, with 12 children in each group. The experimental group performed group activities through multisensory storytelling for 60 min, twice a week for 8 weeks, while the control group performed structured physical activities. Read More

North Clin Istanb 2022 11;9(2):102-108. Epub 2022 Mar 11.

Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey.

Objective: The Modified Ashworth Scale, the Modified Tardieu Scale, and measuring the passive range of motion is commonly preferred examination tools for spasticity in cerebral palsy (CP). Ultrasonography has become increasingly used to provide relevant insight into spastic muscle morphology and structure recently. It was aimed to reveal associations between the clinical and ultrasonographic parameters of gastrocnemius medialis (GM) and lateralis muscles in this population. Read More

Mov Disord Clin Pract 2022 May 12;9(4):508-515. Epub 2022 Apr 12.

Department of Neurology National Center Hospital, National Center of Neurology and Psychiatry Tokyo Japan.

Background: Normal pressure hydrocephalus (NPH) manifests as gait instability, cognitive impairment, and urinary incontinence. This clinical triad of NPH sometimes occurs with ventriculomegaly in patients with neurodegenerative disease. Patients with pathologically verified neurodegenerative diseases, such as progressive supranuclear palsy (PSP), have received antemortem diagnoses of NPH. Read More

World J Orthop 2022 Apr 18;13(4):365-372. Epub 2022 Apr 18.

Department of Orthopaedics, University of Alabama at Birmingham, Birmingham, Al 35294, United States.

Background: Neuromuscular scoliosis is commonly associated with a large pelvic obliquity. Scoliosis in children with cerebral palsy is most commonly managed with posterior spinal instrumentation and fusion. While consensus is reached regarding the proximal starting point of fusion, controversy exists as to whether the distal level of spinal fusion should include the pelvis to correct the pelvic obliquity. Read More

Glia 2022 May 17. Epub 2022 May 17.

Department of Neonatology, Charité University Medicine Berlin, Berlin, Germany.

Preterm infants often show pathologies of the cerebellum, which are associated with impaired motor performance, lower IQ and poor language skills at school ages. Using a mouse model of inflammation-induced encephalopathy of prematurity driven by systemic administration of pro-inflammatory IL-1β, we sought to uncover causes of cerebellar damage. In this model, IL-1β is administered between postnatal day (P) 1 to day 5, a timing equivalent to the last trimester for brain development in humans. Read More

Gait Posture 2022 May 7;96:53-59. Epub 2022 May 7.

Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Background: The purpose of this study was to determine the differences in billable provider charges between single event multilevel surgery (SEMLS) based on comprehensive gait analysis and a staged surgical approach (SSA) without comprehensive gait analysis for the orthopedic treatment of ambulatory children with cerebral palsy (CP).

Methods: The charges associated with nine common orthopedic surgical combinations (both unilateral and bilateral, soft tissue or soft tissue plus bony) for children with CP were determined and compared between SEMLS and SSA. The charges included surgical, anesthesia, operating room, recovery room, hospital stay, physical therapy, and, for SEMLS only, comprehensive computerized gait analysis. Read More

Disabil Rehabil Assist Technol 2022 May 16:1-10. Epub 2022 May 16.

Cerebral Palsy Alliance Research Institute, Child and Adolescent Health, The University of Sydney, Sydney, Australia.

Purpose: Motor speech and augmentative and alternative communication (AAC) interventions are commonly used with children with cerebral palsy (CP) but there is limited literature comparing the effectiveness of these interventions. The purpose of this study was to investigate the effectiveness of intensive AAC, Rapid Syllable Transition Treatment (ReST), and blended intervention, a combination of motor-speech and AAC, on speech accuracy and sentence length and complexity.

Methods: A single case experimental design across participants with repeated measurements across phases (ABACADA design) was used. Read More

J Pediatr Orthop 2022 May 17. Epub 2022 May 17.

Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD.

Introduction: Sacral-alar-iliac (SAI) screws are utilized to achieve pelvic fixation in spine deformity patients. The primary purpose of this study is to investigate the long-term outcomes of pediatric patients with scoliosis treated with posterior spinal fusion and SAI fixation at 10-year clinical and radiographic follow-up.

Methods: We reviewed the clinical and radiographic records of patients aged 18 years or below treated for scoliosis with posterior spinal fusion using SAI fixation. Read More

Disabil Rehabil 2022 May 16:1-11. Epub 2022 May 16.

Children's Health and Exercise Research Centre, Sport & Health Sciences, University of Exeter, Exeter, UK.

Purpose: Cerebral palsy (CP) is the commonest motor disability affecting children. This study reviewed the evidence for virtual reality (VR) intervention compared with conventional physiotherapy in upper limb function of children with CP.

Methods: Searches were undertaken in MEDLINE, EMBASE, PEDro, CENTRAL, Web of Science, CINAHL, ERIC, ICTRP, EU-CTR, ClinicalTrials. Read More

Disabil Rehabil 2022 May 15:1-13. Epub 2022 May 15.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam, Netherlands.

Purpose: To identify determinants of spoken language comprehension (SLC) in children with cerebral palsy (CP).

Materials And Methods: Cross-sectional data of 207 children with CP were included: 82 toddlers (18 months-3;11 years), 59 preschool children (4;0-5;11 years), and 66 schoolchildren (6;0-8;11 years), across all Gross Motor Function Classification System (GMFCS) levels. SLC was assessed using the Computer-Based instrument for Low motor Language Testing (C-BiLLT). Read More

Neuroophthalmology 2022 15;46(3):203-206. Epub 2022 Feb 15.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A broad spectrum of neurological side effects has been reported after immunisation for COVID-19, including functional neurological disorders, cerebral vascular events, cerebral venous thrombosis, intracerebral haemorrhage, neuroleptic malignant syndrome, cranial nerve palsies, and otologic manifestations. Multiple cranial neuropathies have also been reported following vaccination in which involvement of VII nerve is the most prevalent, followed by the VI, III, and IV nerves. We describe two male patients, one with with facial nerve palsy and the other with abducens nerve palsy following COVID-19 vaccination. Read More

Pan Afr Med J 2022 22;41:155. Epub 2022 Feb 22.

Department of Community Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Medical Sciences, Wardha, India.

Hemiplegic cerebral palsy (CP) is a subcategory of CP which is characterized by sensory motor deficits primarily on one side of the body that adversely affects functionality. Virtual reality (VR) systems have been advanced in the recent past for the use in rehabilitation of patients with neurological conditions. Virtual reality has an inherent motivational component that provides the much-needed compliance for active participation by children. Read More

Nutr Rev 2022 May 14. Epub 2022 May 14.

Department of Neurology-Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro Brazil.

Context: Nutritional interventions for newborns with brain injury are scarce, and there are gaps in the knowledge of their mechanisms of action in preventing the occurrence of cerebral palsy (CP) or the incidence of other developmental disabilities.

Objective: The objective of this review was to assess the effect of nutritional interventions in preventing nonprogressive congenital or perinatal brain injuries, or in improving outcomes related to neurological development.

Data Sources: Randomized trials on any nutritional intervention for pregnant women at risk of preterm delivery, or for children with low birth weight, preterm, or with confirmed or suspected microcephaly, CP, or fetal alcohol syndrome disorders (FASDs) were retrieved from MEDLINE, Embase, Scopus, Web of Science, LILACS, and CENTRAL databases from inception to September 17, 2020. Read More

Gait Posture 2022 May 10;96:35-46. Epub 2022 May 10.

School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal, Canada; Research Center of the Sainte-Justine University Hospital (CRCHUSJ), Canada.

Background: Individuals with cerebral palsy (CP) have a reduced ability to perform motor tasks such as walking. During daily walking, they are confronted with environmental constraints such as irregular surfaces (e.g. Read More

J Clin Med 2022 May 2;11(9). Epub 2022 May 2.

Clinic for Orthopedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

A variety of gait pathologies is seen in cerebral palsy. Movement patterns between different levels of functional impairment may differ. The objective of this work was the evaluation of Gross Motor Function Classification System (GMFCS) level-specific movement disorders. Read More

J Clin Med 2022 Apr 28;11(9). Epub 2022 Apr 28.

Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Korea.

Neurodevelopmental disorder (NDD) in preterm infants has become of great interest. We aimed to investigate the impact of preterm birth on the proportion of NDD using nationwide data provided by the Korean National Health Insurance Service. We included 4894 extremely preterm or extremely low-birth-weight (EP/ELBW; <28 weeks of gestation or birth weight < 1000 g) infants, 70,583 other preterm or low-birth-weight (OP/LBW; 28-36 weeks of gestation or birth weight < 2500 g) infants, and 264,057 full-term infants born between 2008 and 2015. Read More

Int J Environ Res Public Health 2022 May 7;19(9). Epub 2022 May 7.

Institute of Health Sciences, University of Rzeszow, 35-959 Rzeszów, Poland.

Background: This study was conducted to evaluate the co-occurrence of hydrocephalus treated/untreated surgically and congenital nervous system disorders or neurological syndromes with symptoms visible since childhood, and with somatic development disorders, based on significant data obtained during admission to a neurological rehabilitation unit for children and adolescents.

Methods: The study applied a retrospective analysis of data collected during hospitalization of 327 children and adolescents, aged 4-18 years, all presenting congenital disorders of the nervous system and/or neurological syndromes associated with at least one neurodysfunction that existed from early childhood. To allow the identification of individuals with somatic development disorders in the group of children and adolescents with hydrocephalus treated/untreated surgically, the adopted criteria considered the z-score values for body height, body weight, head circumference, body mass index, and head circumference index. Read More

Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Dysphagia Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Children with cerebral palsy typically have severe teeth arch malalignment, causing swallowing and respiration dysfunction. Malalignment in cerebral palsy, especially in children, worsens dysphagia and respiratory disorders; sometimes, it is also noted with obstructive sleep apnea. However, no study has reported on the improvement in obstructive sleep apnea after at-home orthodontic treatment in children with cerebral palsy. Read More

Int J Environ Res Public Health 2022 Apr 22;19(9). Epub 2022 Apr 22.

Nursing and Physiotherapy Faculty, Universidad de Salamanca, Avda. Donantes de Sangre, s/n, 37007 Salamanca, Spain.

Cerebral palsy is a neurological condition that is associated with multiple motor alterations and dysfunctions in children. Robotic systems are new devices that are becoming increasingly popular as a part of the treatment for cerebral palsy. A systematic review of the Pubmed, Web of Science, MEDLINE, Cochrane, Dialnet, CINAHL, Scopus, Lilacs and PEDro databases from November 2021 to February 2022 was conducted to prove the effectiveness of these devices for the treatment of motor dysfunctions in children who were diagnosed with cerebral palsy. Read More

Int J Mol Sci 2022 Apr 29;23(9). Epub 2022 Apr 29.

Department of Pediatrics, Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada.

Group B (GBS) is a leading cause of placental infection, termed chorioamnionitis. Chorioamnionitis is associated with an increased risk of neurobehavioral impairments, such as autism spectrum disorders, which are more prominent in males than in female offspring. In a pre-clinical model of chorioamnionitis, a greater inflammatory response was observed in placenta associated with male rather than female fetuses, correlating with the severity of subsequent neurobehavioral impairments. Read More

J Pediatr 2022 May 10. Epub 2022 May 10.

Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: To evaluate changes in mortality or significant neurodevelopmental impairment (sNDI) in children born <29 weeks' gestation in association with national quality improvement initiatives.

Methods: This longitudinal cohort study included children born at 22 to 28 weeks' gestation who were admitted to Canadian NICUs between 2009 and 2016. Primary outcome was a composite rate of death or significant NDI (Bayley-III scores <70, severe cerebral palsy, blindness, or deafness needing amplification) at 18 to 24 months corrected age. Read More

Transl Pediatr 2022 Apr;11(4):556-564

Department of Pediatrics, The Second Affiliated Hospital of Hainan Medical College, Haikou, China.

Background: This study aimed to explore the main risk factors for cerebral palsy in children by meta-analysis of the literature on the risk factors of cerebral palsy.

Methods: We performed a literature search of the PubMed, EMBASE, Medline, and CENTRAL databases using the following search terms: ("cerebrl plsy" or "cerebrl plsis" or "infantile cerebral palsy") and ("risk factors"). Case-control or cohort studies of children with cerebral palsy and healthy children were included for meta-analysis. Read More