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Am J Case Rep 2019 Apr 21;20:562-566. Epub 2019 Apr 21.

Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Pseudomonal infection is the most common cause of malignant otitis externa (MOE), which typically affects elderly diabetic patients. Fungi are a rare cause of MOE. MOE can be life-threatening if not recognized and treated promptly. Read More

Eur J Paediatr Neurol 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Chorioamnionitis is a common and potentially devastating complication of pregnancy associated with maternal and perinatal adverse outcomes.

Objective: To evaluate a possible association between maternal chorioamnionitis and long-term pediatric neurological morbidity.

Study Design: A population-based retrospective cohort analysis was performed comparing the risk of long-term neurological morbidity. Read More

Complement Ther Clin Pract 2019 May 7;35:296-300. Epub 2019 Mar 7.

Children Rehabilitation Center of Huai'an Maternal and Child Health Care Hospital, No.104 People South Road, Huai'an, 223002, China.

Purpose: To use Traditional Chinese Medicine (TCM) and Western approaches to improve gross motor function and activities of daily living (ADL) in children with spastic cerebral palsy.

Methods: Children were randomly divided into a treatment group, which received scalp acupuncture combined with exercise therapy and conventional rehabilitation training, and a control group, which received conventional rehabilitation training alone. Study subjects' gross motor function (gross motor function measure-88 [GMFM-88]) and ADL were evaluated before and after therapy. Read More

Complement Ther Clin Pract 2019 May 25;35:189-194. Epub 2019 Feb 25.

Department of Physiotherapy, Neuropediatrics Section, Federal University of São Carlos, Rod. Washington Luis, Km 235, 13565-905, São Carlos, SP, Brazil.

Background And Purpose: Virtual reality is an adjuvant technique to rehabilitation of children with cerebral palsy (CP). It has been gaining prominence in this field because of its accessibility and great levels of motivation it promotes in treatment. However, there is a lack of studies addressing the effects of virtual reality-based therapy on activity levels regarding postural stability, especially considering the level of evidence presented by studies addressing this issue. Read More

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Neonatal Medicine, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Aim: To evaluate long-term cognitive and behavioural outcomes of children with neonatal hypoxic-ischaemic encephalopathy in the absence of cerebral palsy.

Methods: A systematic search was performed on five databases (EMBASE, Medline, PubMed, Web of Science, PsycInfo). Randomised-controlled trials, non-randomised controlled trials, or observational studies, published between 1990-2017, that reported long-term (age ≥ 4 years) cognitive and/or behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy without cerebral palsy were included. Read More

Malays Orthop J 2019 Mar;13(1):45-48

Department of Orthopaedic and Traumatology, Istanbul Medical Faculty, Istanbul, Turkey.

Aneurysmal bone cysts rather than local aggressive lesions of the bone which may arise in any part of the axial or appendicular skeleton. Although several theories are available in the literature, the pathogenesis is still conflicting. We report an exceptional case of an aneurysmal bone cyst in the distal femur of a female cerebral palsy patient who underwent bilateral distal femoral derotational osteotomy and plate-screw fixation operations when she was 11 years old. Read More

J Pak Med Assoc 2019 Apr;69(4):478-482

University Institute Of Physical Therapy, University of Lahore.

Objective: To evaluate the effect of positioning on tonic labyrinthine reflex in children with cerebral palsy.

Methods: The quasi-experimental study was conducted at the Institute of Psychological Services and Physical Rehabilitation, Lahore, from July 2016 to June 2017, and comprised children with spastic and athetoid cerebral palsy aged six months to three years. Gross Motor Functional Classification Scale level V was taken as baseline measure. Read More

Gait Posture 2019 Apr 9;71:14-19. Epub 2019 Apr 9.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany; Pediatric Orthopaedics and Traumatology, University, Children's Hospital Zurich - Eleonore Foundation, Steinwiesstrasse 75, 8032 Zurich, Switzerland. Electronic address:

Background: Due to the limited knee range of motion, achieving adequate foot clearance while walking on level ground constitutes a major problem for patients with cerebral palsy and stiff knee gait. Stair negotiation as an activity of daily life requires a considerably higher knee range of motion than level ground walking, but little is known yet as to whether such patients are able to walk stairs.

Research Question: The aim of this study was to investigate how patients with a limited knee range of motion negotiate stairs. Read More

J Am Acad Orthop Surg 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Orthopedics, Alfred I. duPont Hospital for Children, Wilmington, DE (Dr. Shrader), the Texas Scottish Rite Hospital for Children, Dallas, TX (Dr. Wimberly), and the Orthopedic Institute for Children, University of California in Los Angeles, Los Angeles, CA (Dr. Thompson).

Hip dysplasia is common in children with cerebral palsy (CP), especially in those children with notable functional impairment. Severity of hip dysplasia has been shown to correlate with higher Gross Motor Function Classification System levels. Migration percentage measured on AP pelvis radiographs is the key radiographic measure quantifying hip displacement in CP. Read More

J Child Orthop 2019 Apr;13(2):190-195

Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Purpose: Previous studies have established the safety and efficacy of tranexamic acid (TXA) in reducing blood loss after total joint arthroplasty and spinal fusion surgery; however, literature regarding the effectiveness of intraoperative TXA in children with cerebral palsy (CP) is limited. The aim of this study was to investigate the safety and efficacy of intraoperative TXA in reducing blood loss and transfusion requirements for children with CP undergoing a proximal femoral varus derotational osteotomy (VDRO).

Methods: This is a retrospective review of 258 children with CP who underwent VDRO performed at the author's institution between 2004 and 2017. Read More

J Child Orthop 2019 Apr;13(2):180-189

Medical Faculty, Department of Interdisciplinary Health Science, University of Oslo, Oslo, Norway.

Purpose: Children with spastic unilateral cerebral palsy (SUCP) frequently undergo lower limb surgery to improve gait. Postoperatively, ankle-foot orthoses (AFOs) are used to maintain the surgical corrections and provide adequate mechanical support. Our aim was to evaluate changes in gait and impacts of AFOs one-year postoperatively. Read More

Disabil Rehabil 2019 Apr 17:1-12. Epub 2019 Apr 17.

a Department of Allied Health Sciences , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.

Purpose: Rehabilitation goals often focus on increasing community integration for adults with disabilities and are measured by objective assessments. Research methods have lagged behind in capturing current conceptualizations of community integration as a multidimensional construct that incorporates participation, social supports, and feelings of belonging in the community. This paper addresses this challenge by describing a multi-method approach to assessing community integration for adults with cerebral palsy. Read More

Early Hum Dev 2019 Apr 13;133:1-4. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Nuchal cord is a common finding in pregnancy. It is unclear whether a nuchal cord at birth causes birth asphyxia and raises the risk for developing cerebral palsy of the offspring.

Aim: To evaluate the incidence of cerebral palsy in children born with and without nuchal cord. Read More

Adolesc Health Med Ther 2019 27;10:21-28. Epub 2019 Mar 27.

Department of Physical Therapy, Graduate Program Physiological Sciences, Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, SE, Brasil.

Purpose: One of the most limiting conditions in cerebral palsy (CP) is the impairment in musculoskeletal mobility. CP may impair the ability to perform efficient movements. The aim of this trial was to investigate the effect of dance on the range of motion (ROM) of lower limbs in young people with CP. Read More

Dev Med Child Neurol 2019 Apr 15. Epub 2019 Apr 15.

Department of Rehabilitation Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Aim: In the context of the development of an International Classification of Functioning, Disability and Health (ICF) Core Set for adults with cerebral palsy (CP), this systematic review sought to identify the outcome measures used in studies on adults with CP, to examine their content using the ICF as a reference, and to demonstrate the most studied areas in this population.

Method: Embase, MEDLINE, Web of Science, PsycINFO, CINAHL, Cochrane, and Google Scholar were searched for studies on adults with CP published between 2000 and 2017. Meaningful concepts of commonly used outcome measures were linked to the ICF, and frequencies of resultant ICF categories were explored. Read More

Front Pediatr 2019 26;7:84. Epub 2019 Mar 26.

Hunan Provincial Center for Disease Control and Prevention, Changsha, China.

In China, the vaccination of children with epilepsy (EP) and cerebral palsy (CP) has no specific protocol. Parents are often concerned that vaccination of their children may cause complications due to negative recommendations from vaccinators, resulting in a decline in vaccination. It is therefore is essential to investigate the vaccination status of these specific populations, and the knowledge, attitudes, and practices (KAP) of vaccinators. Read More

Front Endocrinol (Lausanne) 2019 28;10:186. Epub 2019 Mar 28.

School of Psychology, University of East London, London, United Kingdom.

Children who were growth restricted (FGR) and are born small for gestational age (SGA) may experience poorer long term neurological and cognitive outcomes. Those also born preterm may have particular difficulties. The objective of this paper was to review the literature on school age neurocognitive outcome for term and preterm children that was published in the last 15 years. Read More

Front Neurol 2019 26;10:236. Epub 2019 Mar 26.

Rsgbiogen, New Delhi, India.

Virtual-reality-based training can influence gait recovery in children with cerebral palsy. A consensus concerning its influence on spatiotemporal gait parameters and effective training dosage is still warranted. This study analyzes the influence of virtual-reality training (relevant training dosage) on gait recovery in children with cerebral palsy. Read More

Front Physiol 2019 28;10:227. Epub 2019 Mar 28.

Department of Physiology, Faculty of Medical Health and Sciences, University of Auckland, Auckland, New Zealand.

In human beings the immature brain is highly plastic and depending on the stage of gestation is particularly vulnerable to a range of insults that if sufficiently severe, can result in long-term motor, cognitive and behavioral impairment. With improved neonatal care, the incidence of major motor deficits such as cerebral palsy has declined with prematurity. Unfortunately, however, milder forms of injury characterized by diffuse non-cystic white matter lesions within the periventricular region and surrounding white matter, involving loss of oligodendrocyte progenitors and subsequent axonal hypomyelination as the brain matures have not. Read More

J Neurosurg 2019 Apr 12:1-7. Epub 2019 Apr 12.

OBJECTIVEIntrathecal drug delivery devices (IDDDs) are a mainstay in the treatment of spasticity and refractory pain. While these devices have been shown to greatly improve the quality of life for patients, they also have a high perioperative complication and failure rate. A major complication of IDDD implantation is infection. Read More

Ann Phys Rehabil Med 2019 Apr 9. Epub 2019 Apr 9.

Paediatric Neurology and Neurorehabilitation Unit, Department of Pediatrics, Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address:

Background: There is a lack of objective and reliable tools to measure walking performance in children with cerebral palsy (CP).

Objective: To evaluate the reliability of inertial measurement units (IMUs) measuring daily life walking performance and physical activity (PA) in children with CP and healthy controls.

Methods: Algorithms were developed to analyse data collected with IMUs during 2 standard school days of the same week and 1 weekend day in 15 children with CP and 14 controls. Read More

Ann Phys Rehabil Med 2019 Apr 9. Epub 2019 Apr 9.

Université Libre de Bruxelles (ULB), Centre interuniversitaire de référence pour l'infirmité motrice cérébrale ULB-VUB-ULg, and Inkendaal Rehabilitation Hospital, Inkendaalstraat 1, 1602 Vlezenbeek, Belgium.

Ann Phys Rehabil Med 2019 Apr 9. Epub 2019 Apr 9.

Paediatric Physical and Rehabilitation Department, Ildys Fondation, Ty Yann Establishment, Brest, France; Physical and Rehabilitation Medicine Department, University Hospital of Brest, France; National Institute of Health and Medical Research (INSERM) UMR 1101, Medical Data Treatment (LaTIM), Brest, France; Western Britany University, Brest, France.

Changes in lower extremity bone morphology are potential mid- to long-term secondary consequences of cerebral palsy (CP), affecting activity. Little is known about the 3-D morphology of lower-extremity bones in children with CP and the association with gait deviations. The main aim of this study was to describe and compare 3-D lower-extremity bone morphology in ambulant children with unilateral or bilateral CP. Read More

Data Brief 2019 Jun 21;24:103840. Epub 2019 Mar 21.

Department of Mechanical Engineering, The University of Auckland, Auckland, 1010, New Zealand.

Understanding the underlying mechanisms leading to progressive muscle pathologies in spastic Cerebral Palsy remains a challenging field of research. Furthermore, Botulinum Neurotoxin-A (BoNT-A) is a frequent intervention to treat spasticity in CP but its effects on neuromuscular properties are not yet fully explored. High-density Electromyographic (HD-EMG) data have been collected before and after BoNT-A injections from children aged 5-15 years during isometric contractions of the ankle joint together with torque output, clinical assessments and demographic details. Read More

Cell Death Dis 2019 Apr 11;10(4):325. Epub 2019 Apr 11.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Neonatal hypoxic injury (NHI) is a devastating cause of disease that affects >60% of babies born with a very low birth weight, resulting in significant morbidity and mortality, including life-long neurological consequences such as seizures, cerebral palsy, and intellectual disability. Hypoxic injury results in increased neuronal death, which disrupts normal brain development. Although animal model systems have been useful to study the effects of NHI, they do not fully represent the uniqueness and complexities of the human brain. Read More

Gait Posture 2019 May 30;70:397-402. Epub 2019 Mar 30.

Hasan Kalyoncu University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Gaziantep, Turkey. Electronic address:

Background: The most prominent characteristics of hemiparetic cerebral palsy (hCP) children are structural and functional asymmetries. These children have low walking speeds, endurance and poor balance. The robotic walking devices repeat and experience symmetrical stepping at the corresponding speed and angles of the lower extremities. Read More

PLoS One 2019 11;14(4):e0215220. Epub 2019 Apr 11.

Department of Neonatology, Rigshospitalet, Copenhagen, Denmark.

Aim: The aim of this study was to evaluate long-term behavioural and neurodevelopmental complications of neonatal necrotizing enterocolitis at school age.

Method: This was a historic cohort study comparing all surviving children born in Denmark between 1st of January 2002 and 31st of December 2011 with a diagnosis of necrotizing enterocolitis to a group of children without necrotizing enterocolitis, but same gestational age, birth weight and year of birth. Outcomes were investigated through a parental questionnaire. Read More

Disabil Rehabil 2019 Apr 11:1-7. Epub 2019 Apr 11.

a Institute of Neuroscience, Université Catholique de Louvain , Brussels , Belgium.

Purpose: This study aims to provide normative values of a global activity performance questionnaire (ACTIVLIM-CP) and investigate its ability to discriminate children with cerebral palsy of various functional levels.

Methods: Parents of 503 typically developing children aged 2-18 years old (mean age ± standard deviation (SD): 9.56 ± 4. Read More

Disabil Rehabil 2019 Apr 11:1-11. Epub 2019 Apr 11.

a Centre for Disability and Development Research , Australian Catholic University , Melbourne , Australia.

Purpose: This study identified occupational therapists' viewpoints that guide their practice of upper limb orthosis prescription for children with cerebral palsy (CP).

Methods: A qualitative study utilising Q methodology explored participants' viewpoints. Thirty-nine occupational therapists (38 females) were purposively recruited to rank statements generated from interviews of experienced clinicians and peer reviewed and published literature. Read More

Disabil Rehabil 2019 Apr 11:1-8. Epub 2019 Apr 11.

a Centre de Réadaptation Marie Enfant, Centre de Recherche du CHU Sainte Justine , Montréal , Canada.

Purpose: Cerebral palsy is a neurological disorder not only affecting motor functions but also cognitive and psychosocial dimension. Multispecialty therapies are needed to address these dimensions. Dance practice provides multidimensional benefits for people with various neurological disorders and may present a real potential for people with cerebral palsy. Read More

Eur J Pediatr 2019 Apr 10. Epub 2019 Apr 10.

Center for Orthopaedics and Trauma Surgery, University Hospital Giessen and Marburg, Baldingerstraße, 35041, Marburg, Germany.

Parents whose children are affected by systemic diseases, anomalies, deformities, or further orthopedic defective positions use the Internet to increase their knowledge. However, there have been few studies that focus, as this one does, on Internet enquiries done before the parents contact the pediatric orthopedic surgeon. This study analyzed data gathered through a standardized questionnaire on general habits of Internet use, parents' hardware, age, and educational background of the parents. Read More

Clin Pract Epidemiol Ment Health 2018 31;14:323-333. Epub 2018 Dec 31.

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Background And Objectives: Epilepsy is considered one of the most prevalent causes of morbidity in children. The aim of this study is to determine how epilepsy impacts the lives of children with epilepsy and their families.

Methods: A translated version of the "Impact of Pediatric Epilepsy Scale" (IPES) questionnaire was completed by the 80 mothers of children with epilepsy, recruited at three hospitals in Jeddah, Saudi Arabia This is a validated self-administered questionnaire used to assess the impact of epilepsy on the lives of the child and family, as well as the quality of life (QoL) of the child. Read More

Physiology (Bethesda) 2019 May;34(3):216-229

Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine , Rochester, Minnesota.

Spastic cerebral palsy (CP), despite the name, is not consistently identifiable by specific brain lesions. CP animal models focus on risk factors for development of CP, yet few reproduce the diagnostic symptoms. Animal models of CP must advance beyond risk factors to etiologies, including both the brain and spinal cord. Read More

Aust Occup Ther J 2019 Apr 10. Epub 2019 Apr 10.

Cerebral Palsy Alliance, Discipline of Child and Adolescent Health, The University of Sydney, Camperdown, North South Wales, Australia.

Introduction: Paediatric occupational therapy seeks to improve children's engagement and participation in life roles. A wide variety of intervention approaches exist. Our aim was to summarise the best-available intervention evidence for children with disabilities, to assist families and therapists choose effective care. Read More

Front Physiol 2019 22;10:283. Epub 2019 Mar 22.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current standard treatment for term infants with hypoxic ischemic encephalopathy (HIE) is hypothermia. Because hypothermia is only partially effective, novel therapies are required to improve outcomes further. Read More

J Neurosci Methods 2019 Apr 6;321:12-19. Epub 2019 Apr 6.

Center for Perinatal Research at The Research Institute and Department of Pediatrics at Nationwide Children's Hospital, Columbus, OH, United States; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:

Introduction: In young children, EEG data acquisition during stimulation tasks is difficult due to anxiety, movement and behaviorally-related interruptions, especially in those with disabilities.

New Method: We used standardized music therapy (MT) protocols with and without acclimatization, during and prior to time-locked EEG with a published tactile testing protocol. Our prospective study leveraged a larger trial in children with/without cerebral palsy aged 7-27 months. Read More

J Psychiatry Neurosci 2019 Apr 9;44(3):1-12. Epub 2019 Apr 9.

From the Department of Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (Rus, Reess, Wohlschläger, Koch); the TUM-Neuroimaging Center (TUM-NIC) School of Medicine of Klinikum rechts der Isar, Technische Universität München TUM, Ismaninger Strasse 22, 81675 Munich, Germany (Rus, Reess, Wohlschläger, Koch); the Research Unit of the Buhl-Strohmaier Foundation for Pediatric Neuroorthopaedics and Cerebral Palsy, Department of Orthopedics and Sports Orthopedics, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (Alves-Pinto); the Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany (Rus, Reess, Koch); the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Wagner); the Windach Institute and Hospital of Neurobehavioural Research and Therapy (WINTR), Windach, Germany (Berberich); and the Department of Neuroradiology, University of Zürich, Zürich, Switzerland (Rus).

Background: Obsessive–compulsive disorder (OCD) is characterized by anxiety-provoking, obsessive thoughts. Patients usually react to these thoughts with repetitive behaviours that reduce anxiety and are perceived as rewarding. Hence, reward plays a major role in the psychopathology of OCD. Read More

J Child Neurol 2019 Apr 9:883073819840449. Epub 2019 Apr 9.

8 Adelaide Medical School & Robinson Research Institute, University of Adelaide, Adelaide, Australia.

High throughput sequencing is discovering many likely causative genetic variants in individuals with cerebral palsy. Some investigators have suggested that this changes the clinical diagnosis of cerebral palsy and that these individuals should be removed from this diagnostic category. Cerebral palsy is a neurodevelopmental disorder diagnosed on clinical signs, not etiology. Read More

Semin Fetal Neonatal Med 2019 Mar 28. Epub 2019 Mar 28.

Level 7, Dept of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC, 3052, Australia. Electronic address:

Postnatal corticosteroids are effective in preventing or treating bronchopulmonary dysplasia (BPD) in preterm newborns, but their benefits need to exceed their risks. Several types of corticosteroids, and different timing and administration modes have been trialed. Systemic corticosteroids, given either early or late, have proven efficacy for reducing BPD and the combined outcome of death or BPD. Read More

Sensors (Basel) 2019 Apr 7;19(7). Epub 2019 Apr 7.

Department of Exercise Sciences, Faculty of Science, University of Auckland, Auckland 1023, New Zealand.

The aim of this study is to evaluate if Kinect is a valid and reliable clinical gait analysis tool for children with cerebral palsy (CP), and whether linear regression and long short-term memory (LSTM) recurrent neural network methods can improve its performance. A gait analysis was conducted on ten children with CP, on two occasions. Lower limb joint kinematics computed from the Kinect and a traditional marker-based Motion Analysis system were investigated by calculating the root mean square errors (RMSE), the coefficients of multiple correlation (CMC), and the intra-class correlation coefficients (ICC). Read More

Nutr Hosp 2019 Apr 8. Epub 2019 Apr 8.

Nuevo Hospital Civil de Guadalajara.

Introduction: children with cerebral palsy (CP) have multiple risk factors for low bone mineral density or osteoporosis.

Objective: to explore the association between bone mineral density (BMD) and biochemical and hormonal indicators of bone metabolism in children with quadriplegic cerebral palsy (CP).

Methods: a cross-sectional analytical study included 59 participants from six to 18 years of age with quadriplegic CP. Read More

Comput Methods Biomech Biomed Engin 2019 Apr 8:1-8. Epub 2019 Apr 8.

a Department of Electronics and Information Systems , Institute Biomedical Technology (IBiTech) - bioMMeda, Ghent University , Gent , Belgium.

The purpose of this study was to create and validate a standardized framework for the evaluation of the ankle stiffness of two designs of 3D printed ankle foot orthoses (AFOs). The creation of four finite element (FE) models allowed patient-specific quantification of the stiffness and stress distribution over their specific range of motion during the second rocker of the gait. Validation was performed by comparing the model outputs with the results obtained from a dedicated experimental setup, which showed an overall good agreement with a maximum relative error of 10. Read More

Eur J Cardiothorac Surg 2019 Apr 8. Epub 2019 Apr 8.

Department of Cardiovascular Surgery, German Aortic Center Hamburg, University Heart Center Hamburg, Hamburg, Germany.

Objectives: This study aims to analyse the impact of a simplified frozen elephant trunk (FET) technique on early outcome.

Methods: Between October 2010 and August 2018, 92 consecutive patients (mean age 64.4 ± 12. Read More

Ideggyogy Sz 2019 Mar;72(3-4):115-122

Pécsi Egyetem, Általános Orvostudományi Kar, Gyermekgyógyászati Klinika, Pécs.

Background And Purpose: The purpose of our communication was to determine the total cost of cerebral paretic patients in Hungary between 0 and 18 years and to assess their impact on the national budget.

Methods: Based on the data of Borsod county we calculated the CP characteristics. The cost of CP was determined by routine care of individuals. Read More

J Stroke Cerebrovasc Dis 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address:

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is definitely diagnosed by genetic testing. Such testing involves the analysis of exons 2-24 of NOTCH3, which encode the epidermal growth factor-like repeat domain, where CADASIL mutations are localized. We previously reported clinical diagnostic criteria for screening CADASIL-suspected Japanese patients prior to genetic testing. Read More

Acta Paediatr 2019 Apr 7. Epub 2019 Apr 7.

Children's Hospital, Paediatric Research Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Aim: We sought to evaluate the associations between umbilical artery pH and base excess and neurodevelopmental outcome at four years of age.

Methods: This study comprised 84,588 singleton children born alive at term in 2005-2011 in the hospital district of Helsinki and Uusimaa in Finland. Data from the maternity hospital information system were linked to the data from the Medical Birth Register and the Hospital Discharge Register. Read More

BMJ Case Rep 2019 Apr 5;12(4). Epub 2019 Apr 5.

Pediatric Neurology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Clin Biomech (Bristol, Avon) 2019 Mar 20;65:26-33. Epub 2019 Mar 20.

Department of Kinesiology, KU Leuven, Leuven, Belgium.

Background: Selective dorsal rhizotomy aims to reduce spasticity in children with cerebral palsy. Early investigations indicated postoperative weakness, whereas more recent studies showed that selective dorsal rhizotomy either does not change or improves muscle strength. All previous studies assessed muscle strength in a static position, which did not represent the walking situation. Read More

J Neuroophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Neuro Ophthalmology (JIB, AC, JIA), Dr. Elias Santana Hospital, Santo Domingo, Dominican Republic; and Diagnostica SA (JMP), Santo Domingo, Dominican Republic.

An 83-year-old man presented with a 1-year history of abducens palsy. Brain MRA revealed arterial dolichoectasia of most cerebral vessels, including the basilar, internal carotid, and middle cerebral arteries. Abducens nerve palsy as a sole manifestation of diffuse intracranial dolichoectasia is unusual but may occur in diffuse intracranial dolichoectasia. Read More

Dev Med Child Neurol 2019 Apr 5. Epub 2019 Apr 5.

Regional Rehabilitation Centre, Queen Silvia Children's Hospital, Gothenburg, Sweden.

Aim: To describe the prevalence of cerebral palsy (CP), subtype distribution, motor and intellectual impairment, and epilepsy in adults with CP compared with children with CP.

Method: CP subtype and impairment data from the population-based CP register of western Sweden and population data from Statistics Sweden were used to compare surviving adults (n=581; 244 females, 337 males) born between 1959 and 1978, with the same cohort as children (n=723; 307 females, 416 males), and with the most recent cohort, born from 2007 to 2010 (n=205; 84 females, 121 males).

Results: Prevalence of CP in adults born between 1959 and 1978 was 1. Read More