30,211 results match your criteria Cerebral Palsy


Prediction of Neurodevelopmental Impairment in Congenital Cytomegalovirus Infection by Early Postnatal Magnetic Resonance Imaging.

Neonatology 2020 Jun 3:1-7. Epub 2020 Jun 3.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

Introduction: Congenital cytomegalovirus infection (CCMVI) may result in neurodevelopmental impairments (NDIs) such as hearing loss, developmental delay, epilepsy, and cerebral palsy. We aimed to investigate the potential for brain magnetic resonance imaging (MRI) to predict NDI in patients with CCMVI.

Methods: We studied infants with CCMVI who were referred to our hospital from April 2010 to October 2018 and underwent a brain MRI within 3 months since birth. Read More

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http://dx.doi.org/10.1159/000508218DOI Listing

miR-135b-dependent down-regulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model.

Am J Physiol Cell Physiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, P. R., China.

Cerebral palsy (CP) is frequently caused by brain injury during pregnancy, delivery or the immediate postnatal period. The differentiation potential of neural stem cell (NSC) makes them effective in restoring injured tissues and organs with minimal risks of side effects. In this study, we identified a novel microRNA-135b (miR-135b) in CP, and investigated its functional role in mediating NSC differentiation. Read More

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http://dx.doi.org/10.1152/ajpcell.00481.2019DOI Listing

Documenting change with the Canadian Occupational Performance Measure for children with cerebral palsy.

Dev Med Child Neurol 2020 Jun 3. Epub 2020 Jun 3.

Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.

Aim: To assess the Canadian Occupational Performance Measure's (COPM) ability to document change over 3 years in children with cerebral palsy (CP).

Method: This was a prospective study with ambulatory children with CP, aged 2 to 6 years. Caregivers set one to three COPM goals which were rescored annually over 3 years. Read More

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http://dx.doi.org/10.1111/dmcn.14569DOI Listing

Umbilical cord arterial blood gas analysis in term singleton pregnancies: a retrospective analysis over 11 years.

Obstet Gynecol Sci 2020 May 13;63(3):293-304. Epub 2020 Apr 13.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: Given that the large volume of data on cord arterial blood gas analysis (ABGA) have been rarely addressed in Korean population, we aimed to examine the incidence, associated factors, and neonatal outcomes in cases of low cord pH, and investigate the incidence of cerebral palsy (CP).

Methods: From data of all consecutive term singleton pregnancies delivered in our institution from 2006 to 2016 (n=15,701), cases with cord ABGA (n=14,221) available were included. We collected information on maternal clinical characteristics and delivery outcomes and also examined neonatal and infant outcomes, including neonatal intensive care unit (NICU) admission and CP, in cases with low cord pH, defined as a pH <7. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.3.293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231949PMC

Use of Shear Wave Elastography for Quantitative Assessment of Muscle Stiffness After Botulinum Toxin Injection in Children With Cerebral Palsy.

J Ultrasound Med 2020 Jun 3. Epub 2020 Jun 3.

Departments of Physical Medicine and Rehabilitation, Health Sciences University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: This study aimed to investigate the stiffness of the gastrocnemius (GC) muscle with acoustic radiation force impulse (ARFI) elastography after botulinum toxin-A (BTX-A) injection in children with spastic cerebral palsy (CP) and to examine the relationship between elastographic and clinical parameters.

Methods: This prospective randomized single-blind controlled clinical study included 49 lower extremities of 33 children with spastic CP. They were randomized into 2 groups: group 1 (n = 25 extremities in 17 children) received BTX-A injection and a home-based exercise program; group 2 (n = 24 extremities in 16 children) received only a home-based exercise program. Read More

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http://dx.doi.org/10.1002/jum.15342DOI Listing

Effectiveness of different parenting interventions on oral hygiene of cerebral palsy children: A randomized controlled trial.

Spec Care Dentist 2020 Jun 2. Epub 2020 Jun 2.

Department of Public Health Dentistry, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Aim: To assess the effectiveness of different parenting interventions for improving oral hygiene of cerebral palsy (CP) children aged 4-12 years.

Methodology And Results: A randomized controlled trial was done among 60 CP children and parents visiting a tertiary care center in New Delhi. The study population was randomly assigned to experimental or control group (30 in each group). Read More

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http://dx.doi.org/10.1111/scd.12481DOI Listing

Inequalities in treatment planning for children with intellectual disabilities: A questionnaire study of dentists in Europe.

Spec Care Dentist 2020 Jun 2. Epub 2020 Jun 2.

Aix Marseille Université, CNRS, EFS, ADES, Marseille, France.

Background: Children with intellectual disabilities experience major inequality in the field of oral health, including a higher number of extracted teeth. The literature explains this difference in terms of higher levels of dental disease but does not mention the possibility of inequality in the treatment options offered these children.

Aim: The aim is to investigate whether the same treatment options are offered by practitioners to children with and without intellectual disability in equivalent clinical circumstances. Read More

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http://dx.doi.org/10.1111/scd.12482DOI Listing

General Movement Assessment Predicts Neuro-Developmental Outcome in Very Low Birth Weight Infants at Two Years - A Five-Year Observational Study.

Indian J Pediatr 2020 Jun 3. Epub 2020 Jun 3.

Neonatal Intensive Care Unit, James Cook University Hospital, Marton road, Middlesbrough, TS4 3BW, UK.

Objective: To assess the value of general movements (GMs) in predicting the neurodevelopmental outcome using Bayley Scale of Infant Development III (BSID-III) at two years of age in very low birth weight (VLBW) infants.

Methods: This is a five-year observational study (January 2012-June 2017). Two hundred twenty-seven VLBW infants were assessed in the neurodevelopmental clinic between Jan 2012 and June 2017. Read More

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http://dx.doi.org/10.1007/s12098-020-03365-1DOI Listing

Muscle activity in children with spastic unilateral cerebral palsy when walking with ankle-foot orthoses: an explorative study.

Gait Posture 2020 May 23;80:31-36. Epub 2020 May 23.

Oslo Centre for Biostatistics and Epidemiology, University of Oslo - Domus Medica, Sognsvannsveien 9, 0372 Oslo, Norway.

Background: A hinged ankle-foot orthosis is prescribed for children with spastic unilateral cerebral palsy to improve gait function by correcting spastic equinus. However, little is known about how orthotic management relates to muscle activity during walking in this population.

Research Question: Does muscle activity in medial gastrocnemius and tibialis anterior change in children with spastic unilateral cerebral palsy when walking with hinged ankle-foot orthoses featuring two different footplate designs?

Methods: In this prospective, repeated-measures trial, electromyographic activity in medial gastrocnemius and tibialis anterior was recorded from 17 children (mean age: 8. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.011DOI Listing

The importance of communication classifications in cerebral palsy registers.

Dev Med Child Neurol 2020 Jun 2. Epub 2020 Jun 2.

Division of Communication Disorders, University of Wyoming, Laramie, WY, USA.

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http://dx.doi.org/10.1111/dmcn.14571DOI Listing

Cerebral palsy is a sensorimotor disorder.

Authors:
Bernard Dan

Dev Med Child Neurol 2020 Jul;62(7):768

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http://dx.doi.org/10.1111/dmcn.14542DOI Listing

Impact of pain on affective disorders among adults with cerebral palsy.

Dev Med Child Neurol 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1111/dmcn.14570DOI Listing

The Participation and Environment Measure-Plus: a useful new tool for caregivers and professionals.

Authors:
Jennifer Lyman

Dev Med Child Neurol 2020 Jun 2. Epub 2020 Jun 2.

Parent of 15-year-old with cerebral palsy, New Orleans, LA, USA.

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http://dx.doi.org/10.1111/dmcn.14586DOI Listing

Aortic Isthmus Doppler Velocimetry in Fetuses with Intrauterine Growth Restriction: A Literature Review.

Rev Bras Ginecol Obstet 2020 May 29;42(5):289-296. Epub 2020 May 29.

Fetal Medecine Post Graduation, Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil.

Intrauterine growth restriction (IUGR) is associated with poor perinatal prognosis and a higher risk of stillbirth, neonatal death, and cerebral palsy. Its detection and the evaluation of its severity by new Doppler velocimetric parameters, such as aortic isthmus (AoI), are of great relevance for obstetrical practice. The AoI is a vascular segment that represents a point of communication between the right and left fetal circulations. Read More

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http://dx.doi.org/10.1055/s-0040-1710301DOI Listing

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome.

Theranostics 2020 27;10(13):5736-5748. Epub 2020 Apr 27.

Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore MD, 21231.

: Elevated glutamate production and release from glial cells is a common feature of many CNS disorders. Inhibitors of glutaminase (GLS), the enzyme responsible for converting glutamine to glutamate have been developed to target glutamate overproduction. However, many GLS inhibitors have poor aqueous solubility, are unable to cross the blood brain barrier, or demonstrate significant toxicity when given systemically, precluding translation. Read More

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http://dx.doi.org/10.7150/thno.41714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254984PMC

Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice.

Regen Med 2020 Jun 1. Epub 2020 Jun 1.

Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran 14177-44361, Iran.

Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Read More

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http://dx.doi.org/10.2217/rme-2019-0119DOI Listing

Structured Observation of Motor Performance in Infants: level and quality associate to later motor development.

Acta Paediatr 2020 May 31. Epub 2020 May 31.

Department of Women's and Children's health, Uppsala University, Sweden.

Aim: The aim of this study was to investigate the level of motor development and the quality of motor performance during the first 10 months in relation to the Bayley Scales of Infant Development-third edition (Bayley-III) motor index at 2.5 years.

Methods: Children born very preterm from a population-based study (n=113) were assessed with the Structured Observation of Motor Performance in-Infants (SOMP-I) at 2, 4, 6 and 10 months corrected age and the Bayley-III motor index at 2. Read More

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http://dx.doi.org/10.1111/apa.15377DOI Listing

Hand Function at 18-22 Months Is Associated with School-Age Manual Dexterity and Motor Performance in Children Born Extremely Preterm.

J Pediatr 2020 May 28. Epub 2020 May 28.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA.

Objectives: To determine associations between 18-22 month (early) hand function and scores on the Movement Assessment Battery for Children, 2 edition (MABC) at 6-7 years of age (school-age) in extremely preterm children.

Study Design: Prospective multi-center cohort of 313 extremely preterm children with early hand function assessment and school-age MABC testing. Early hand function was compared with 'definite deficits' (MABC <5 percentile) and MABC standard scores. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.05.048DOI Listing

Managing to learn bimanual activities - experiences from children and adolescents with cerebral palsy - a qualitative analysis.

Disabil Rehabil 2020 May 29:1-9. Epub 2020 May 29.

Institute of Neuroscience and Physiology at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Children and adolescents with cerebral palsy often have impaired hand function. This makes it difficult for them to deal with everyday activities. The aim of the study was to explore the experiences of children and adolescents with unilateral spastic cerebral palsy when it comes to learning and dealing with activities requiring bimanual use. Read More

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http://dx.doi.org/10.1080/09638288.2020.1768305DOI Listing

Long-term motor outcomes of very preterm and/or very low birth weight individuals without cerebral palsy: A review of the current evidence.

Semin Fetal Neonatal Med 2020 May 20:101116. Epub 2020 May 20.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Finnish Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Oulu, Finland; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

We reviewed literature on long-term motor outcomes of individuals aged five years or older born very preterm (VP: ≤32 weeks of gestation) or with very low birth weight (VLBW: ≤1500g), without cerebral palsy (CP). PubMed produced 2827 articles, whereof 38 were eligible. Assessed by standardised and norm-based motor tests, the Movement Assessment Battery for Children being the most widely used, VP/VLBW individuals showed poorer motor skills compared with term-born controls with differences of approximately 1 SD in magnitude. Read More

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http://dx.doi.org/10.1016/j.siny.2020.101116DOI Listing

Antenatal Corticosteroids and Outcomes in Preterm Twins.

Obstet Gynecol 2020 Jun;135(6):1387-1397

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, and the Divisions of Perinatology and Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, and the Department of Biostatistics and Bioinformatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

Objective: To estimate whether improvement in outcomes from antenatal corticosteroid treatment in extremely and very preterm twins is similar to that observed in singletons, and to investigate whether antenatal corticosteroid treatment has different effects according to chorionicity or birth order.

Methods: This population-based study was based on an analysis of data collected by the Neonatal Research Network of Japan from 2003 to 2015 of neonates weighing 1,500 g or less at birth, from gestational ages of 24 0/7 to 31 6/7 weeks of gestation. After propensity score matching, univariate logistic and interaction analyses were performed to compare short-term (neonatal period) and medium-term (3 years of age) outcomes of the children of mothers who received antenatal corticosteroids with those of children of mothers who did not receive antenatal corticosteroids. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003881DOI Listing

Communication Modes and Functions in Children With Cerebral Palsy.

J Speech Lang Hear Res 2020 May 27:1-17. Epub 2020 May 27.

Department of Communication Sciences and Disorders, University of Wisconsin-Madison.

Purpose This study seeks to determine how speech-language impairments relate to the frequency and diversity of communication modes and functions produced by children with cerebral palsy (CP) during interactions with their mothers. Method We studied 40 children with CP ( = 62 months) comprising three groups: those who were unable to speak and had anarthria ( = 15), those with speech motor impairment and language comprehension impairment (SMI-LCI; = 15), and those with speech motor impairment and typical language comprehension (SMI-LCT; = 10). Mother-child play interactions were coded for child modes and functions. Read More

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http://dx.doi.org/10.1044/2020_JSLHR-19-00228DOI Listing

A case study on interface pressure pattern of two garment orthoses on a child with cerebral palsy.

Proc Inst Mech Eng H 2020 May 27:954411920923541. Epub 2020 May 27.

Centre for Applied Biomechanics, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.

Many studies have shown that medical compression products produce different levels of interface pressure during the usage of the products. However, limited studies have explored the pattern of interface pressure exerted by orthotic garments. This case study aimed to investigate the pattern of interface pressure exerted by two types of orthotic garments on a child with cerebral palsy. Read More

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http://dx.doi.org/10.1177/0954411920923541DOI Listing

Influence of Aquatic Therapy in Children and Youth with Cerebral Palsy: A Qualitative Case Study in a Special Education School.

Int J Environ Res Public Health 2020 May 23;17(10). Epub 2020 May 23.

Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, Alcorcón, 28922 Madrid, Spain.

Cerebral palsy results in the progressive loss of motor functions, with a negative impact on daily activities and participation. Despite the well described benefits of aquatic therapy in children, little is known about the effects of the same in school settings. This study aimed to describe the experience of children and youth with cerebral palsy participating in an aquatic therapy program within a special education school considering their educational and therapeutic perspectives. Read More

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http://dx.doi.org/10.3390/ijerph17103690DOI Listing

Postnatal Corticosteroids Policy for Very Preterm Infants and Bronchopulmonary Dysplasia.

Neonatology 2020 May 26:1-8. Epub 2020 May 26.

Department of Neonatology, Jeanne de Flandre Hospital, Lille CHRU, Lille, France.

Introduction: Postnatal corticosteroids (PNC) are effective for reducing bronchopulmonary dysplasia (BPD) in very preterm neonates but are associated with adverse effects including an increased risk of cerebral palsy. PNC use in Europe is heterogeneous across regions. This study aimed to assess whether European neonatal intensive care units (NICUs) with a low use of PNC or an explicit policy to reduce PNC use had higher risks of mortality or BPD. Read More

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http://dx.doi.org/10.1159/000507195DOI Listing

Comparison of Staged Versus Same-day Bilateral Hip Surgery in Nonambulatory Children With Cerebral Palsy.

J Pediatr Orthop 2020 May 22. Epub 2020 May 22.

Rady Children's Hospital, San Diego, San Diego, CA.

Background: Bilateral hip reconstructions with osteotomies are commonly required in patients with severe cerebral palsy (CP) and dysplasia. These procedures can be performed by staging each hip surgery, separated by weeks to months, or by addressing both hips in a single-event surgery. The optimal timing of such surgery is yet to be determined. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001595DOI Listing

[Advances on selective posterior rhizotomy for lower limb function in patients with cerebral palsy].

Zhongguo Gu Shang 2020 May;33(5):489-92

The Fourth Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700, China.

Cerebral palsy is a common clinical syndrome of neurological disability in childhood, which seriously affects the quality of life of children and their families, and brings a heavy economic burden to the society. Domestic and foreign scholars had a long history of the application of selective posterior rhizotomy for the treatment of spastic cerebral palsy or mixed cerebral palsy with limb paralysis. It is effective in improving the lower extremity spasm of patients with cerebral palsy, and there are few cases with recurrences. Read More

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http://dx.doi.org/10.12200/j.issn.1003-0034.2020.05.020DOI Listing

Diffuse excessive high signal intensity on term equivalent MRI does not predict disability: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2020 May 25. Epub 2020 May 25.

Neonatal Intensive Care Unit, King Edward Memorial Hospital for Women Perth, Subiaco, Western Australia, Australia.

Objective: To evaluate whether diffuse excessive high signal intensity (DEHSI) on term equivalent age MRI (TEA-MRI) predicts disability in preterm infants.

Design: This is a systematic review and meta-analysis. Medline, EMBASE, Cochrane Library, EMCARE, Google Scholar and MedNar databases were searched in July 2019. Read More

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http://dx.doi.org/10.1136/archdischild-2019-318207DOI Listing

Have outcomes following extremely preterm birth improved over time?

Semin Fetal Neonatal Med 2020 May 15:101114. Epub 2020 May 15.

Victorian Infant Brain Studies, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Rd, Parkville, VIC, 3052, Australia; Level 7, Dept of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, 20 Flemington Road, Parkville, VIC, 3052, Australia; Dept of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:

Increased survival of infants born preterm, especially those born extremely preterm (<28 weeks' gestation), has meant that more are reaching later childhood and adulthood. As preterm birth is associated with a higher risk of neurodevelopmental deficits, the aim of this review was to determine whether or not the advances in perinatal care that led to improved survival have also had a positive impact on long-term neurodevelopment. Studies examining temporal changes in neurodevelopment are limited, and only from high-income countries. Read More

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http://dx.doi.org/10.1016/j.siny.2020.101114DOI Listing

Awakening cortisol indicators, advanced glycation end products, stress perception, depression and anxiety in parents of children with chronic conditions.

Psychoneuroendocrinology 2020 May 19;117:104709. Epub 2020 May 19.

Department of Public Health, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia.

This cross-sectional study aims to investigate awakening cortisol indicators and to explore their association with stress perception, advanced glycation end products (AGEs), depression and anxiety in parents of children with chronic conditions. We included five parental groups according to children's diagnoses: Down syndrome (DS; N = 31), autistic spectrum disorder (ASD; N = 29), cerebral palsy (CP; N = 15), diabetes mellitus type 1 (DMT1; N = 38), and a control group of heathy children (CG; N = 33). Salivary cortisol and AGEs were measured, alongside with psychological indices. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2020.104709DOI Listing

Tailored interventions to reduce hospital admissions for individuals with cerebral palsy.

Dev Med Child Neurol 2020 May 24. Epub 2020 May 24.

Department of Medicine, University of Wisconsin School of Medicine and Public Health University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.1111/dmcn.14566DOI Listing

Effects of dual task on gait velocity and cadence in cerebral palsied children with spastic hemiparesis or diparesis.

Acta Neurol Belg 2020 May 24. Epub 2020 May 24.

Department of Physiotherapy and Rehabilitation, Faculty of Health Science, Avrasya University, Trabzon, Turkey.

Gait is generally considered an automated process with little or no cognitive input. In most individuals with Cerebral Palsy (CP), walking restrictions may accompany during childhood and adolescence. The aim of this study was to determine the effects of dual task on Gait Velocity (GV) and Cadence (C) in Cerebral Palsied Children with Spastic Hemiparesis or Diparesis (CPCSHD). Read More

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http://dx.doi.org/10.1007/s13760-020-01380-9DOI Listing

10-Valent pneumococcal non-typeable protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: study protocol for a randomised controlled trial.

BMJ Open 2020 May 24;10(5):e033511. Epub 2020 May 24.

Child Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

Introduction: and non-typeable (NTHi) are major otitis media pathogens that densely co-colonise the nasopharynx and infect the middle ear of Australian Aboriginal infants from very early in life. Our co-primary hypotheses are that at 18 months of age infants receiving 10-valent pneumococcal protein D conjugate vaccine (PHiD-CV10) compared with those receiving 13-valent pneumococcal conjugate vaccine (PCV13) as a booster at 12 months of age will have higher antibody levels to protein D and that infants receiving PCV13 will have higher antibody levels to PCV13-only serotypes 3, 6A and 19A.

Methods And Analyses: Our randomised controlled trial will enrol 270 Aboriginal children at 12 months of age to a booster dose of either PHiD-CV10 or PCV13. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033511DOI Listing

Electroclinical spectrum of childhood epilepsy secondary to neonatal hypoglycemic brain injury in a low resource setting: A 10-year experience.

Seizure 2020 May 20;79:90-94. Epub 2020 May 20.

Neurology Division, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.

Purpose: Neonatal hypoglycemic brain injury (NHBI) is being increasingly recognized as an important cause of drug resistant childhood epilepsy in low resource settings. We report the electro-clinical spectrum of children with epilepsy secondary to NHBI.

Methods: This was a retrospective study of children enrolled in the Epilepsy Clinic from January 2009 to August 2019. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.05.010DOI Listing
May 2020
2.059 Impact Factor

Cerebral Palsy.

J Pediatr Rehabil Med 2020 May 15. Epub 2020 May 15.

Clinical Pediatric Rehabilitation Medicine Attending at Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.3233/PRM-200022DOI Listing

The association of hepatoblastoma, prematurity and cerebral palsy: Case reports.

J Pediatr Rehabil Med 2020 May 15. Epub 2020 May 15.

Department of Pediatric Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, IL, USA.

Purpose: Hepatoblastoma is the most common primary liver tumor in children and has a greater incidence in children with a history of prematurity and very low birth weight. To increase awareness of the association between prematurity and hepatoblastoma for health care providers who treat children with Cerebral Palsy (CP), we present two case reports.

Methods: Two case reports of premature, very low birth weight infants with hepatoblastoma are described and a literature review of hepatoblastoma in the setting of prematurity and cerebral palsy is performed. Read More

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http://dx.doi.org/10.3233/PRM-190662DOI Listing

Effects of solid ankle-foot orthoses with individualized ankle angles on gait for children with cerebral palsy and equinus.

J Pediatr Rehabil Med 2020 May 9. Epub 2020 May 9.

College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.

Purpose: For children with cerebral palsy (CP) and equinus, the conventional practice of setting the ankle angle in an ankle-foot orthosis (AA-AFO) at 90∘ may not adequately accommodate gastrocnemius length/stiffness. Therefore, this study compared the effects of statically-optimized solid AFOs with individualized AA-AFOs (iAA-AFOs) and conventionally-prescribed AFOs on gait for children with CP and equinus.

Methods: Ten children with CP and equinus (15 limbs with AFOs), and 15 typically-developing (TD) children participated. Read More

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http://dx.doi.org/10.3233/PRM-190615DOI Listing

Lessons learned from conducting a pragmatic, randomized, crossover trial on robot-assisted gait training in children with cerebral palsy (PeLoGAIT).

J Pediatr Rehabil Med 2020 May 9. Epub 2020 May 9.

Swiss Children's Rehab, Research Department, University Children's Hospital Zurich, Eleonore Foundation, Affoltern am Albis, Switzerland.

Purpose: To investigate the effectiveness of outpatient robot-assisted gait training (RAGT) in ambulatory children with spastic cerebral palsy.

Methods: Children were randomized to two different intervention sequences within a pragmatic crossover design. They performed five weeks of RAGT (3 sessions per week) and five weeks of usual care (UC). Read More

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http://dx.doi.org/10.3233/PRM-190614DOI Listing

Immediate effect of induced fatigue of the unaffected limb on standing balance, proprioception and vestibular symptoms in children with hemiplegia.

J Pediatr Rehabil Med 2020 May 15. Epub 2020 May 15.

Paediatrics Department, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.

Objectives: To study the effect of induced fatigue of the unaffected limb on the sensory components of standing balance; proprioception and vestibular symptoms in children with hemiplegic cerebral palsy.

Methods: Setting: Outpatient Clinic of Faculty of Physical Therapy, Cairo University.

Patients: Twenty-nine children with hemiplegic cerebral palsy [(ages 8. Read More

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http://dx.doi.org/10.3233/PRM-180587DOI Listing

Repeated episodes of pediatric constraint induced movement therapy with a gross motor training component: A prospective cohort study.

J Pediatr Rehabil Med 2020 May 9. Epub 2020 May 9.

Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, USA.

Purpose: To examine the results of repeated episodes of 21-day pediatric constraint induced movement therapy (PCIMT) paired with gross motor training (GMT).

Methods: Nineteen children, age 14 months - 6 years with unilateral upper extremity impairment enrolled in this cohort study to receive repeated episodes of 21 day PCIMT-GMT. Outcome measures included the Peabody Developmental Motor Scales-2 (PDMS-2), the Assisting Hand Assessment (AHA) and the Canadian Occupational Performance Measure (COPM). Read More

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http://dx.doi.org/10.3233/PRM-180543DOI Listing

Effects of robot-assisted gait training alongside conventional therapy on the development of walking in children with cerebral palsy.

Authors:
Hamza Sucuoglu

J Pediatr Rehabil Med 2020 May 9. Epub 2020 May 9.

Purpose: To investigate the effects of robot-assisted gait training (RAGT) alongside conventional therapy on the standing and walking abilities of children with cerebral palsy (CP).

Methods: The study sample consisted of children (aged 4-18 years) with CP whose gross motor function classification system (GMFCS) was at levels I-V. In total, 75 children with CP were evaluated and 38 patients completed the study. Read More

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http://dx.doi.org/10.3233/PRM-180541DOI Listing

Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes.

Semin Fetal Neonatal Med 2020 May 15:101115. Epub 2020 May 15.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA. Electronic address:

Among individuals born very preterm, perinatal inflammation, particularly if sustained or recurring, is highly likely to contribute to adverse neurodevelopmental outcomes, including cerebral white matter damage, cerebral palsy, cognitive impairment, attention-deficit/hyperactivity disorder, and autism spectrum disorder. Antecedents and correlates of perinatal inflammation include socioeconomic disadvantage, maternal obesity, maternal infections, fetal growth restriction, neonatal sepsis, necrotizing enterocolitis, and prolonged mechanical ventilation. Genetic factors can modify susceptibility to perinatal inflammation and to neurodevelopmental disorders. Read More

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http://dx.doi.org/10.1016/j.siny.2020.101115DOI Listing

Effects of reflexology on child health: A systematic review.

Complement Ther Med 2020 May 3;50:102364. Epub 2020 Mar 3.

Akdeniz University, Faculty of Nursing, Department of Pediatric Nursing, Antalya, Turkey. Electronic address:

Background: It is known that the parents of one of every two children who need health care seek at least one complementary health-care approach. Reflexology, which is one of these, increases well-being while maintaining the continuity of homeostasis. As studies with children are limited, there is a need for evidence that includes the positive as well as the negative effects of reflexology that can be transferred to clinical practice and recommendations for future studies. Read More

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http://dx.doi.org/10.1016/j.ctim.2020.102364DOI Listing

Relationship Between Transverse-plane Kinematic Deviations of Lower Limbs and Gait Performance in Children with Unilateral Cerebral Palsy: A Descriptive Analysis.

Authors:
Ragab K Elnaggar

Gait Posture 2020 May 11;79:224-228. Epub 2020 May 11.

Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt; Department of Physical Therapy and Health Rehabilitation, Collage of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia. Electronic address:

Background: Transverse-plane kinematic deviations of lower limbs are common in children with unilateral cerebral palsy (UCP), often with detrimental consequences for gait.

Research Question: To identify the most important factor among rotational anomalies of lower limbs for gait in children with UCP.

Methods: In a descriptive observational study, 42 children with UCP (age; 5-8 years) who had the ability of independent walking were included. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.003DOI Listing

Effect of Robot-Assisted Gait Training on Selective Voluntary Motor Control in Ambulatory Children with Cerebral Palsy.

Indian Pediatr 2020 May 22. Epub 2020 May 22.

Department of Nursing Care, Faculty of Health Sciences, University of Primorska, Polje, Izola, Republic of Slovenia.

This pilot study investigated the efficacy of a four week robot-assisted gait training in twelve childrenwith spastic diparesis. Short-term results and a 3-month follow-up showed statistically significantly increased selective motor control, walking farther distances, gross motor score, and decreased joint contractures. Read More

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Nutritional status and prevalence of dysphagia in cerebral palsy: Usefulness of the Eating and Drinking Ability Classification System scale and correlation with the degree of motor impairment according to the Gross Motor Function Classification System.

Neurologia 2020 May 18. Epub 2020 May 18.

Unidad de Digestivo Infantil, Instituto del Niño y del Adolescente, Hospital Clínico San Carlos, Madrid, España.

Introduction And Objectives: Digestive disorders are one of the most common comorbidities among children with cerebral palsy (CP). The aim of this study is to examine the nutritional status of patients with CP, the prevalence of dysphagia by degree of motor impairment, and the impact of digestive disorders on quality of life.

Material And Methods: We conducted a descriptive, cross-sectional, open-label study of outpatients with CP from a tertiary hospital in the Region of Madrid using a structured interview, classifying dysphagia using the Eating and Drinking Ability Classification System (EDACS). Read More

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http://dx.doi.org/10.1016/j.nrl.2019.12.006DOI Listing

Congenital Zika Syndrome-Assessing the Need for a Family Support Programme in Brazil.

Int J Environ Res Public Health 2020 May 19;17(10). Epub 2020 May 19.

International Centre for Evidence on Disability, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

The Zika outbreak in Brazil caused congenital impairments and developmental delays, or Congenital Zika Syndrome (CZS). We sought to ascertain whether a family support programme was needed and, if so, could be adapted from the Getting to Know Cerebral Palsy programme (GTKCP) designed for children with cerebral palsy (CP). We conducted a systematic review of the needs of families of children with CZS or CP in low- and middle-income countries and reviewed the findings of the Social and Economic Impact of Zika study. Read More

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http://dx.doi.org/10.3390/ijerph17103559DOI Listing

Neuroprotective Effects of Diabetes Drugs for the Treatment of Neonatal Hypoxia-Ischemia Encephalopathy.

Front Cell Neurosci 2020 6;14:112. Epub 2020 May 6.

UCL School of Pharmacy, University College London, London, United Kingdom.

The perinatal period represents a time of great vulnerability for the developing brain. A variety of injuries can result in death or devastating injury causing profound neurocognitive deficits. Hypoxic-ischemic neonatal encephalopathy (HIE) remains the leading cause of brain injury in term infants during the perinatal period with limited options available to aid in recovery. Read More

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http://dx.doi.org/10.3389/fncel.2020.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218053PMC

Physical demands by para-footballers with cerebral palsy in a small-sided game.

J Sports Med Phys Fitness 2020 May 20. Epub 2020 May 20.

Miguel Hernandez University, Sport Research Centre, Elche, Spain -

Background: Cerebral Palsy (CP) Football is a para-sport performed by individuals with physical impairments of athetosis, ataxia, or hypertonia. However, little is known about the physical demands of para-footballers with CP, and no previous study has analysed those demands in a small-sided game (SSG). This study aims to describe physical parameters using a Global Positioning System device in an SSG played by CP Football players. Read More

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http://dx.doi.org/10.23736/S0022-4707.20.10514-0DOI Listing

Self-care performance in children with cerebral palsy: a longitudinal study.

Dev Med Child Neurol 2020 May 19. Epub 2020 May 19.

Faculty of Medicine, Queensland Cerebral Palsy and Rehabilitation Research Centre, Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.

Aim: To investigate self-care developmental trajectories in children with cerebral palsy (CP) across all functional ability levels, according to Manual Ability Classification System (MACS) levels.

Method: This was a prospective longitudinal population-based study of 71 children aged from 2 years 6 months to 12 years, with CP (47 [66%] males, 24 [34%] females). Pediatric Evaluation of Disability Inventory (PEDI) measures were taken at 2 years 6 months, 3, 4, and 5 years, and the PEDI - Computer Adaptive Test (PEDI-CAT) between 8 and 12 years. Read More

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http://dx.doi.org/10.1111/dmcn.14561DOI Listing