Search Our Scientific Publications & Authors

Eur Stroke J 2016 Dec 19;1(4):320-329. Epub 2016 Oct 19.

Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.

Introduction: Although persons with one first-degree relative with aneurysmal subarachnoid haemorrhage have an increased risk of aneurysm formation and aneurysmal subarachnoid haemorrhage, screening them for unruptured intracranial aneurysms was not beneficial in a modelling study from the 1990s. New data on the risk of aneurysmal subarachnoid haemorrhage in these persons and improved treatment techniques call for reassessment of the cost-effectiveness of screening.

Patients And Methods: We used a cost-effectiveness analysis using a Markov model and Monte Carlo simulation comparing screening and preventive aneurysm treatment with no screening in persons with one first-degree relative with aneurysmal subarachnoid haemorrhage. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, Japan.

Background: Intracranial vascular injury incurred during surgery must be repaired as fast as possible. The standard repair procedure is surgical suturing. However, the narrow and deep working space may obstruct creating a knot with the suture thread. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address:

Objective: We test the hypothesis that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale (mRS). Acute seizures were determined as seizures within one week following aSAH. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Background: Flow diversion (FD) has emerged as an effective treatment modality for aneurysms of the posterior communicating artery (PCOM). Whether or not a fetal posterior circulation (FPC) affects PCOM aneurysm occlusion rates after FD remains undetermined.

Methods: We performed a retrospective cohort study in which treatment outcomes for FD of PCOM aneurysms from multiple institutions were reviewed. Read More

Br J Neurosurg 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.

A hyperplastic anterior choroidal artery is a vascular anomaly where the anterior choroidal artery supplies the posterior cerebral artery territory. We report a case of subarachnoid hemorrhage from a hyperplastic anterior choroidal artery with tandem fusiform aneurysms. The patient underwent a temporal craniotomy and transcortical transventricular transchoroidal-fissure approach for clip reconstruction. Read More

J Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Wisconsin, Milwaukee, Wisconsin; Division of Infectious Disease, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, University of Virginia, Box 800212, Charlottesville, Virginia, USA 22908. Electronic address:

Object: Despite the development of four grading scales of angiographic outcome after flow diversion for cerebral aneurysms, none have been widely adopted in the neurosurgical literature nor have any been validated in an independent dataset. We evaluated the reported grading scales for their ability to predict aneurysm occlusion at follow up.

Methods: Four reported grading scales were applied in a retrospective analysis of our prospectively maintained institutional database of patients with intracranial aneurysms treated with flow diverting stents. Read More

J Neuroimaging 2019 Apr 19. Epub 2019 Apr 19.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Purpose: Aneurysm hemodynamics play an important role in aneurysm growth and subsequent rupture. Within the available hemodynamic characteristics, particle residence time (PRT) is relatively unexplored. However, some studies have shown that PRT is related to thrombus formation and inflammation. Read More

Brain Circ 2019 Jan-Mar;5(1):32-35. Epub 2019 Mar 27.

Department of Neurology, UT Health McGovern School of Medicine, Houston, Texas, USA.

Objective: The objective of this study was to investigate patterns of utilization and safety of extracranial-intracranial (EC-IC) bypass in patients with symptomatic cerebrovascular steno-occlusive disorders.

Methods: Patients with one of the steno-occlusive conditions (defined as symptomatic intracranial stenosis, extracranial stenosis, and moyamoya disease) were identified using all nonfederal hospitalizations in New York (2005-2014) and Florida (2005-2015). EC-IC bypass surgery was defined using the corresponding procedure codes. Read More

J Neurosci Rural Pract 2019 Apr-Jun;10(2):194-200

Department of Neurosurgery, Kasturba Medical College, Manipal, Karnataka, India.

Aim: Carotid artery ligation carries a potential risk of ischemic complications even in patients with good collaterals and adequate cross-circulation. Preoperative assessment through balloon test occlusion (BTO) is technically challenging and not feasible in all patients. We analyze our experience with universal bypass without performing detailed cerebrovascular reserve (CVR) studies in 23 patients before carotid artery ligation. Read More

Disabil Rehabil 2019 Apr 18:1-7. Epub 2019 Apr 18.

b Division of Cardiovascular Sciences , The University of Manchester, Core Technology Facility , Manchester , UK.

Background: Despite advances in the acute care of subarachnoid haemorrhage, longer-term services remain under-developed. Clinical measures are commonly used to assess outcome and quality of life, but patient-reported needs and the extent to which they are met have not been measured. This information is essential to plan and develop evidence-based, patient-centred services. Read More

Neuroradiol J 2019 Apr 18:1971400919845368. Epub 2019 Apr 18.

1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: Aneurysms arising from the communicating segment (C7) of the internal carotid artery (ICA) are one of the most frequent locations of intracranial aneurysms. Stent-assisted coiling (SAC) and flow diversion therapies are both endovascular strategies used for the treatment of ICA aneurysms occurring at the C7 segment.

Objective: The aim of this study is to compare both methods' angiographic and functional outcomes, and procedural complications. Read More

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: While superficial temporal artery (STA) to middle cerebral artery (MCA) anastomosis is a beneficial treatment for hemorrhagic moyamoya disease, indeterminate mechanisms can cause rebleeding even after successful bypass surgery. The authors describe a case with a prominent collateral from the lenticulostriate artery (LSA) causing multiple recurrent hemorrhages after successful STA-MCA anastomosis.

Case: Description: A 49-year-old Japanese woman with moyamoya disease was referred to our institution after suffering intracranial hemorrhage on two occasions. Read More

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurological Surgery; Hospital Clinic de Barcelona, University of Barcelona.

Objective: To describe the technique and initial experience using a rotational 3D fluoroscopy system (O-arm, Medtronic) as intraoperative angiography (IA) in the surgery of cerebral aneurysms.

Methods: The 3D IA with O-arm (IAWOA) was performed in a consecutive cohort of patients with unruptured intracranial aneurysms. Conventional microsurgical clipping was performed with the assistance of indocyanine green videoangiography (ICGVA). Read More

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: In clipping surgery, it is advantageous to dissect an adhered artery from the aneurysmal dome to achieve complete clipping. Bypass surgery is useful to reconstruct an adhered artery when dissection of the artery is technically difficult or risky. Here, we report the effectiveness of tailor-made intracranial (IC)-IC bypass to reconstruct an adhered artery in clipping surgery for middle cerebral artery (MCA) aneurysms. Read More

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330000, China P.R. Electronic address:

Background: Dysfunction of endothelial cells (ECs) constitutes a critical factor in formatting intracranial aneurysms (IAs). However, little is known about the response of ECs to hemodynamic insults and its contribution to IA formation.

Methods And Material: IAs models were constructed in both adult female New Zealand white rabbits and male Sprague-Dawley rats. Read More

Angiol Sosud Khir 2019 ;25(1):75-78

Regional Clinical Hospital #2, Tyumen, Russia.

The presence of an ipsilateral aneurysm in stenosis of the internal carotid artery is determined by the findings of CT angiography in 1.8-3.2% of cases. Read More

J Am Heart Assoc 2019 May;8(9):e011201

2 Hubrecht Institute (Royal Netherlands Academy of Arts and Sciences (KNAW)) University Medical Center, Utrecht the Netherlands.

Background We previously showed that intracranial aneurysm ( IA )-associated single-nucleotide polymorphisms are enriched in promoters and putative enhancers identified in the human circle of Willis, on which IA s develop, suggesting a role for promoters and enhancers in IAs . We further investigated the role of putative enhancers in the pathogenesis of IA by identifying their potential target genes and validating their regulatory activity. Methods and Results Using our previously published circle of Willis chromatin immunoprecipitation and sequencing data, we selected 34 putative enhancers in IA -associated regions from genome-wide association studies. Read More

Acta Neurochir (Wien) 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurosurgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, Saga, 849-8501, Japan.

Background: The most frequent neurological complication during coil embolization of a ruptured cerebral aneurysm is a thromboembolic event. The association between the tortuosity of the internal carotid artery (ICA) and thromboembolic events (TEEs) during coil embolization of ruptured cerebral aneurysms remains unclear. The present study aimed to investigate the association between extracranial ICA tortuosity and thromboembolic complications during coil embolization of anterior circulation ruptured aneurysms. Read More

Eur Radiol 2019 Apr 11. Epub 2019 Apr 11.

TENSOR- Team of NeuroSurgery-Oriented Research, Jagiellonian University Medical College, Kraków, Poland.

Objectives: We decided to perform computer-aided analysis of the anterior cerebral artery (ACA) to check for a potential correlation with anterior communicating artery (ACoA) aneurysm presence and growth.

Methods: We retrospectively analyzed the ACA anatomy of 121 patients with ACoA aneurysms along with 121 age, risk factors, and vessel side-matched control patients without an ACoA aneurysm. We obtained their medical history and digital subtraction angiography (DSA) data from their medical records. Read More

Sci Rep 2019 Apr 15;9(1):6054. Epub 2019 Apr 15.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Iron and its derivatives play a significant role in various physiological and biochemical pathways, and are influenced by a wide variety of inflammatory, infectious, and immunological disorders. We hypothesized that iron and its related factors play a role in intracranial aneurysm pathophysiology and investigated if serum iron values are associated with ruptured intracranial aneurysms. 4,701 patients with 6,411 intracranial aneurysms, including 1201 prospective patients, who were diagnosed at the Massachusetts General Hospital and Brigham and Women's Hospital between 1990 and 2016 were evaluated. Read More

Neurosurgery 2019 May;84(5):E272-E273

Introduction: Subarachnoid hemorrhage from a ruptured intracranial aneurysm poses a significant health hazard due to its high rates of mortality and disability. The 2 most commonly used treatment modalities of intracranial aneurysms are neurosurgical clipping and endovascular coiling. Through the decision on which treatment option should be chosen in every case is made based on medical indication, nevertheless, due to high socioeconomic burden of subarachnoid hemorrhage, it is also important to compare the healthcare expenditures, caused by clipping and coiling. Read More

J Stroke Cerebrovasc Dis 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurology, University of Toledo, Toledo, Ohio. Electronic address:

Background And Purpose: To determine recent treatment and outcome trends in patients undergoing elective surgical clipping (SC) or endovascular therapy (EVT) for unruptured intracranial aneurysms (UIAs) in the United States.

Methods: Data were extracted and analyzed from the National Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality for all patients admitted for elective EVT or SC of UIAs between 2011 and 2014. Treatment trends, in-hospital mortality, complication rates, length of stay (LOS) and total hospital costs were evaluated and analyzed. Read More

World Neurosurg 2019 Apr 10. Epub 2019 Apr 10.

Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea. Electronic address:

Background: The unilateral interhemispheric approach is a well-known operative technique for distal anterior cerebral artery (DACA) aneurysms. However, this approach presents several risks, such as postoperative venous infarction due to occasional sacrifice of the parasagittal bridging vein or postoperative frontal lobe damage due to retraction force. To overcome these risks, we used a bifrontal craniotomy with a straight dural incision and cutting of the superior sagittal sinus (SSS). Read More

Semin Thorac Cardiovasc Surg 2019 Apr 10. Epub 2019 Apr 10.

Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). Electronic address:

Background: The management of the aortic arch aneurysm is becoming increasingly complex and multidisciplinary. It has evolved since the first successful repair by DeBakey and colleagues in 1957. After these initial repairs, the improvement in open surgical techniques, cardiopulmonary bypass, anesthesia, and perioperative care were the primary drivers of the decrease in morbidity and mortality associated with repair. Read More

J Magn Reson Imaging 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiology, Peking University First Hospital, Beijing, China.

Background: Compressed sensing (CS) has been widely used to improve the speed of MRI, but the feasibility of application in 3D intracranial MR angiography (MRA) needs to be evaluated in clinical practice.

Purpose: To evaluate the clinical feasibility of CS-MRA in comparison with conventional 3D-MRA (Con-MRA).

Study Type: Retrospective. Read More

J Neurointerv Surg 2019 Apr 12. Epub 2019 Apr 12.

Cerebrovascular Center, Cleveland Clinic, Cleveland, Ohio, USA.

Introduction: The low-profile Neuroform Atlas stent received FDA Humanitarian Device Exemption status (HDE) in January 2018 for stent-assisted coil embolization of wide-necked saccular aneurysms. We review and report our results with the Atlas stent in our institution within the first year after its HDE approval.

Methods: Our retrospective chart review identified patients treated with the Atlas stent. Read More

J Neurointerv Surg 2019 Apr 12. Epub 2019 Apr 12.

Neurological Surgery, University of Washington, Seattle, WA, USA.

Objectives: To study the correlation between wall shear stress and endothelial cell expression in a patient-specific, three-dimensional (3D)-printed model of a cerebral aneurysm.

Materials And Methods: A 3D-printed model of a cerebral aneurysm was created from a patient's angiogram. After populating the model with human endothelial cells, it was exposed to media under flow for 24 hours. Read More

J Neurosurg 2019 Apr 12:1-9. Epub 2019 Apr 12.

1Center for Neurosurgery and.

OBJECTIVECerebral infarction is a significant cause of morbidity and mortality related to microsurgical clipping of intracranial aneurysms. The objective of this study was to determine the impact of aneurysm shape and neck configuration on cerebral infarction after aneurysm surgery.METHODSThe authors retrospectively reviewed consecutive cases of ruptured and unruptured aneurysms treated with microsurgical clipping at their institution between 2010 and 2018. Read More

J Neurointerv Surg 2019 Apr 11. Epub 2019 Apr 11.

NEURI, Hopital Bicetre, Le Kremlin-Bicetre, France.

Background: Aneurysms of the anterior communicating artery (ACoA) are difficult to treat with coiling or clipping because of the anatomical variation in this region. Flow diversion represents a feasible treatment, but no consensus exists as to which stent deployment technique is more suitable.

Methods: All patients with ACoA aneurysms treated with flow diverters between April 2014 and November 2018 were retrospectively analyzed. Read More

AJNR Am J Neuroradiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Biostatistics (N.Y.), Kyoto University, Kyoto, Japan.

Background And Purpose: Cerebral aneurysms have significantly different rupture rates depending on their size and location. The mechanisms underlying these differences are unclear. We examined whether anatomic rupture risks are dependent on the hemodynamic environment on the aneurysmal surface. Read More

AJNR Am J Neuroradiol 2019 Apr 11. Epub 2019 Apr 11.

From the Neuroradiology Department, University Hospital Gui De Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.

Background And Purpose: The intrasaccular flow disruptor, the Woven EndoBridge device, is increasingly used for the treatment of wide-neck intracranial aneurysms. Due to unfavorable anatomy, additional stent placement is sometimes required to avoid Woven EndoBridge protrusion into bifurcation branches. We report our experience with the Woven EndoBridge associated with stent placement for the treatment of complex intracranial aneurysms. Read More

World Neurosurg 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurosurgery, Houston Methodist Hospital, 6560 Fannin Street, Houston, TX 77030. Electronic address:

Cerebral revascularization is used in the treatment of treat complex aneurysms and acute and chronic cerebral occlusive disease. While STA-MCA remains the workhorse of extracranial-intracranial bypass, several approaches for the same have been developed during the past half century. The maxillary artery has shown feasibility in cadaveric studies, and utility in living patients, for achieving successful surgical revascularization. Read More

Ann Neurol 2019 Apr 11. Epub 2019 Apr 11.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Flow diverters are new generation stents that have recently garnered a large amount of interest for use in treatment of intracranial aneurysms. Flow diverters reduce blood flow into the aneurysm, with redirection along the path of the parent vessel. Flow stagnation into the aneurysm and neck coverage with subsequent endothelialization are the important synergistic mechanisms by which the therapy acts. Read More

Neurosurg Rev 2019 Apr 10. Epub 2019 Apr 10.

Hemorrhagic Brain Pathology Research Group, Kuopio University Hospital, Kuopio, Finland.

Oral bacteria DNA has been found in intracranial aneurysms (IA) and a high prevalence of periodontitis was reported in IA patients. We investigated whether periodontitis associates with IA formation and aneurysmal subarachnoid hemorrhage (aSAH). First, we compared in a case-control setting the prevalence of periodontal disease in IA patients (42 unruptured IA, 34 ruptured IA) and in age- and gender-matched controls (n = 70) from the same geographical area (Health 2000 Survey, BRIF8901). Read More

Front Neurosci 2019 26;13:233. Epub 2019 Mar 26.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background And Objectives: Intraoperative aneurysm rupture (IOR) is a difficult event during the clipping process for intracranial aneurysms, and could result in a bad prognosis. Preoperative discrimination of aneurysms with high risk of IOR is vital for operators. The aim of this study was to explore the hemodynamic-morphological risk factors for the IOR. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):338-344

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.

The subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysms (IAs) is always a lethality. Increasing evidence suggests a familiar aggregation of IA occurrence, which may relate to genetics and there might be an increasing number of IAs in IA families when mutation of disease genes is aggregating. With the progress in the study of familiar intracranial aneurysms (FIAs), a large number of chromosome fragments are found to be related with IAs, such as 1p36, 5q31, 7q11, 14q22, 17cen, 19q13, Xp22. Read More

Acta Neurochir (Wien) 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, No. 50 Yikesong Rd, Haidian District, Beijing, 100093, China.

Serpentine aneurysms of the posterior cerebral artery (PCA) treated by the internal maxillary artery (IMA) bypass are rare. Here, the authors report the case of a 34-year-old male patient who presented with a half-year history of gradual severe headache and right-sided limb monoparesis and paresthesia lasting for 1 week. Preoperative angiograms showed a serpentine aneurysm in the left distal PCA, which was treated with internal maxillary artery-radial artery-posterior cerebral artery (IMA-RA-PCA) bypass followed by parent artery occlusion (PAO). Read More

Phys Fluids (1994) 2019 Mar 26;31(3):031905. Epub 2019 Mar 26.

Department of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.

A simple parameter, called the Aneurysm number () which is defined as the ratio of transport to vortex time scales, has been shown to classify the flow mode in simplified aneurysm geometries. Our objective is to test the hypothesis that can classify the flow in patient-specific intracranial aneurysms (IA). Therefore, the definition of this parameter is extended to anatomic geometries by using hydraulic diameter and the length of expansion area in the approximate direction of the flow. Read More

Phys Fluids (1994) 2019 Mar 26;31(3):031904. Epub 2019 Mar 26.

Department of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.

Non-dimensional parameters are routinely used to classify different flow regimes. We propose a non-dimensional parameter, called Aneurysm number (), which depends on both geometric and flow characteristics, to classify the flow inside aneurysm-like geometries (sidewalls and bifurcations). The flow inside aneurysm-like geometries can be widely classified into (i) the vortex mode in which a vortex ring is formed and (ii) the cavity mode in which a stationary shear layer acts similar to a moving lid of a lid-driven cavity. Read More

Neural Regen Res 2019 Aug;14(8):1364-1366

Division of Cerebrovascular and Skull Base Neurosurgery, Institute of Neurosurgery Dr Asenjo, Santiago, Chile.

Clipping and coiling are currently the two alternatives in treatment of ruptured cerebral aneurysms. In spite of some meritorious analysis, further discussion is helpful to understand the actual state of art. Retreatment and rebleeding rates clearly favors clipping, although short-term functional outcome seems to be beneficial for clipping, while this different is not such if we perform the comparison at a longer follow up. Read More

Pharmazie 2019 Mar;74(3):142-146

This study aimed to investigate the treatment effects and molecular mechanism of 3-aminobenzamide (3-AB) on intracranial aneurysms (IA). The IA model was established in male Sprague-Dawley (SD) rats and sham group was set up without ligation. The rats were intraperitoneally injected with normal saline in sham and model control groups and 10 mg/kg, 20 mg/kg and 40 mg/kg 3-AB for low, middle and high 3-AB groups for 3 months, respectively. Read More

Polymers (Basel) 2019 Apr 5;11(4). Epub 2019 Apr 5.

School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USA.

Conventional endovascular embolization of intracranial (or brain) aneurysms using helical detachable platinum coils can be time-consuming and occasionally requires retreatment due to incomplete coil packing. These shortcomings create a need for new biomedical devices and methods of achieving brain aneurysm occlusion. This paper presents a biocompatible and highly porous shape memory polymer (SMP) material with potential applications in the development of novel endovascular devices for treating complex intracranial aneurysms. Read More

World Neurosurg 2019 Apr 5. Epub 2019 Apr 5.

Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea.

Objective: Although mannitol is widely used to facilitate brain retraction in cases of ruptured aneurysms, there is no consensus about the intraoperative administration of mannitol in the case of unruptured aneurysms. Accordingly, this study was conducted to identify an intraoperative mannitol administration strategy.

Methods: Mannitol was routinely administered to patients (n = 90) from January 2015 to April 2016, and not administered to patients (n = 97) from May 2016 to June 2017. Read More

World Neurosurg 2019 Apr 5. Epub 2019 Apr 5.

Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: and purpose: The use of the pipeline embolization device (PED) for posterior circulation aneurysms remains controversial. In this meta-analysis, we aimed to explore the safety and efficacy of PED for these aneurysms. Meta regression was used to identify predictors for incomplete aneurysm occlusion and procedure-related complications. Read More

PLoS One 2019 8;14(4):e0213372. Epub 2019 Apr 8.

Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center, Utrecht, the Netherlands.

Background And Purpose: Patient and aneurysm characteristics have been reported to differ between patients with familial and non-familial intracranial aneurysms (IAs), although results are inconsistent. We systematically reviewed and meta-analyzed the literature to identify and quantify patient- and aneurysm characteristics associated with familial IAs.

Methods: We searched PubMed and EMBASE for case-control and cohort studies comparing patient- and aneurysm characteristics between familial and non-familial IAs. Read More

Acta Neurochir (Wien) 2019 Apr 6. Epub 2019 Apr 6.

Departments of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo Chuo-ku, Kumamoto, 860-8556, Japan.

Radiation therapy is associated with the subsequent development of cerebral aneurysms; however, stereotactic radiosurgery (SRS)-associated aneurysm cases have not been well documented, with only 18 cases reported to date. We present a case of intracranial aneurysms with the rupture occurring 20 years after SRS for a growth hormone-producing pituitary adenoma. This is the first report of aneurysms diagnosed following transsphenoidal surgery and SRS for pituitary adenoma. Read More

World Neurosurg 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

There are some controversies about the surgical treatment strategy of mirror aneurysms. Whether to take one-stage or two-stages surgery, bilateral or unilateral craniotomy, surgical or interventional treatment is the main points in dispute. The present review mainly introduces the different surgery strategies facing with different patients. Read More

J Neuroradiol 2019 Apr 5. Epub 2019 Apr 5.

Neuroradiology department, University Hospital Gui-de-Chauliac, CHU de Montpellier, 34000 Montpellier, France.

Background: Unfavorable aneurysm anatomy can make microwire navigation challenging, increasing the risk of complications. We present our experience of WEB-assisted microcatheterization in complex aneurysms.

Clinical Presentation: Flow diversion was performed for three wide-neck large/giant intracranial aneurysms. Read More

J Biomech 2019 Mar 27. Epub 2019 Mar 27.

Mechanical Engineering Department, Northern Arizona University, Flagstaff, AZ, USA. Electronic address:

Flow stagnation and residence time (RT) are important features of diseased arterial flows that influence biochemical transport processes and thrombosis. RT calculation methods are classified into Eulerian and Lagrangian approaches where several measures have been proposed to quantify RT. Each of these methods has a different definition of RT, and it is not clear how they are related. Read More