2,961 results match your criteria Cerebral Amyloid Angiopathy


Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report.

BMC Neurol 2019 Feb 12;19(1):26. Epub 2019 Feb 12.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Background: Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presented with multiple intracerebral hemorrhages and a simultaneously occurring cerebral infarction with hemorrhagic transformation.

Case Presentation: A 63-year-old male with no history of trauma or prior neurological disease presented with a sudden onset of weakness in his right limbs, followed by an episode of focal seizure without impaired awareness. Read More

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http://dx.doi.org/10.1186/s12883-019-1248-zDOI Listing
February 2019
1 Read

Cerebral microbleeds: Beyond the macroscope.

Int J Stroke 2019 Feb 12:1747493019830594. Epub 2019 Feb 12.

1 Department of Medical Pharmacology, Univ Lille, Inserm U1171-Degenerative and Vascular Cognitive Disorders, CHU Lille, Lille, France.

While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They can be found in different neurological settings such as cerebrovascular or neurodegenerative diseases. Read More

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http://dx.doi.org/10.1177/1747493019830594DOI Listing
February 2019
1 Read

Convexity Subarachnoid Hemorrhage Secondary to Adalidumab in a Patient with Ulcerative Colitis.

J Vasc Interv Neurol 2018 Nov;10(2):62-64

Department of Neurology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

The TNF-α antagonists are the drugs used for the treatment of ulcerative colitis (UC). Nontraumatic convexity subarachnoid hemorrhage is an infrequent nonaneurysmal subtype of subarachnoid bleeding caused mainly by reversible cerebral vasoconstriction syndrome (RCVS), cerebral amyloid angiopathy, and posterior reversible encephalopathy syndrome (PRES). We present a 26-year-old female patient with a diagnosis of UC taking Adalimumab. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350865PMC
November 2018
1 Read

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain.

Front Aging Neurosci 2019 23;11. Epub 2019 Jan 23.

Mathematical Sciences, University of Southampton, Southampton, United Kingdom.

The human brain is the organ with the highest metabolic activity but it lacks a traditional lymphatic system responsible for clearing waste products. We have demonstrated that the basement membranes of cerebral capillaries and arteries represent the lymphatic pathways of the brain along which intramural periarterial drainage (IPAD) of soluble metabolites occurs. Failure of IPAD could explain the vascular deposition of the amyloid-beta protein as cerebral amyloid angiopathy (CAA), which is a key pathological feature of Alzheimer's disease. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357927PMC
January 2019
1 Read

Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.

J Neurol Sci 2019 Feb 1;399:3-5. Epub 2019 Feb 1.

Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.01.051DOI Listing
February 2019

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease.

Acta Neuropathol 2019 Feb 7. Epub 2019 Feb 7.

Faculté de pharmacie, Université Laval, Quebec, QC, Canada.

Several pieces of evidence suggest that blood-brain barrier (BBB) dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD), exemplified by the frequent occurrence of cerebral amyloid angiopathy (CAA) and the defective clearance of Aβ peptides. However, the specific role of brain microvascular cells in these anomalies remains elusive. In this study, we validated by Western, ELISA and immunofluorescence analyses a procedure to generate microvasculature-enriched fractions from frozen samples of human cerebral cortex. Read More

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http://dx.doi.org/10.1007/s00401-019-01967-4DOI Listing
February 2019
3 Reads

Multiple Approaches to Diffusion Magnetic Resonance Imaging in Hereditary Cerebral Amyloid Angiopathy Mutation Carriers.

J Am Heart Assoc 2019 Feb;8(3):e011288

1 Department of Radiology Leiden University Medical Center Leiden the Netherlands.

Background Cerebral amyloid angiopathy ( CAA ) is a major cause of lobar intracerebral hemorrhage in elderly adults; however, presymptomatic diagnosis of CAA is difficult. Hereditary cerebral hemorrhage with amyloidosis-Dutch type ( HCHWA -D) is a rare autosomal-dominant disease that leads to pathology similar to sporadic CAA . Presymptomatic HCHWA -D mutation carriers provide a unique opportunity to study CAA -related changes before any symptoms have occurred. Read More

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http://dx.doi.org/10.1161/JAHA.118.011288DOI Listing
February 2019

Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation.

J Neurol Sci 2019 Jan 3;398:107-116. Epub 2019 Jan 3.

Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Introduction: The novel D678H amyloid precursor protein (APP) gene mutation has been called the "Taiwan mutation". The study aims to identify amyloid deposition patterns and clinical features associated with this mutation.

Methods: we analyzed the clinical manifestations, brain neuroimages and F-AV-45 positron emission tomography (PET) findings in symptomatic patients and asymptomatic subjects with the autosomal-dominant Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.039DOI Listing
January 2019
1 Read

Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.

Neurology 2019 Jan 30. Epub 2019 Jan 30.

From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.

Objective: We sought to determine the underlying mechanism for altered white matter diffusion tensor imaging (DTI) measures at the histopathologic level in patients with cerebral amyloid angiopathy (CAA).

Methods: Formalin-fixed intact hemispheres from 9 CAA cases and 2 elderly controls were scanned at 3-tesla MRI, including a diffusion-weighted sequence. DTI measures (i. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007005DOI Listing
January 2019

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy.

Acta Neuropathol Commun 2019 Jan 28;7(1):12. Epub 2019 Jan 28.

Department of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui, 910-1193, Japan.

Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia. Biological molecules affecting the development of CAA have not been fully characterized. In this study, we performed proteome analysis of biopsied leptomeningeal and cortical vessels obtained from 6 CAA patients and 5 non-CAA patients who underwent surgery for large lobar hemorrhages. Read More

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http://dx.doi.org/10.1186/s40478-019-0662-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348632PMC
January 2019

Comparison of methods for multivariate gene-based association tests for complex diseases using common variants.

Eur J Hum Genet 2019 Jan 25. Epub 2019 Jan 25.

Bioinformatics Graduate Program, Boston University, Boston, MA, USA.

Complex diseases are usually associated with multiple correlated phenotypes, and the analysis of composite scores or disease status may not fully capture the complexity (or multidimensionality). Joint analysis of multiple disease-related phenotypes in genetic tests could potentially increase power to detect association of a disease with common SNPs (or genes). Gene-based tests are designed to identify genes containing multiple risk variants that individually are weakly associated with a univariate trait. Read More

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http://dx.doi.org/10.1038/s41431-018-0327-8DOI Listing
January 2019

Vasoprotective Functions of High-Density Lipoproteins Relevant to Alzheimer's Disease Are Partially Conserved in Apolipoprotein B-Depleted Plasma.

Int J Mol Sci 2019 Jan 22;20(3). Epub 2019 Jan 22.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

High-density lipoproteins (HDL) are known to have vasoprotective functions in peripheral arteries and many of these functions extend to brain-derived endothelial cells. Importantly, several novel brain-relevant HDL functions have been discovered using brain endothelial cells and in 3D bioengineered human arteries. The cerebrovascular benefits of HDL in healthy humans may partly explain epidemiological evidence suggesting a protective association of circulating HDL levels against Alzheimer's Disease (AD) risk. Read More

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http://dx.doi.org/10.3390/ijms20030462DOI Listing
January 2019

Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy.

Neurology 2019 Feb 23;92(8):e792-e801. Epub 2019 Jan 23.

From the Institute for Stroke and Dementia Research (F.A.W., C.O., C.C., R.M., M. Duering, M.J.K., M. Dichgans), University Hospital, LMU Munich; Klinik für Neurologie (C.O.), SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany; Stroke Unit-Neurology Unit and Neuroradiology Unit (M.Z., R.P.), Arcispedale Santa Maria Nuova, Azienda Unità Sanitaria Locale-IRCCS Reggio Emilia, Italy; Serviço de Neurologia (R.S., M.C.), Centro Hospitalar do Porto, Hospital de Santo António, Portugal; Hospital de la Santa Creu i Sant Pau (J.M.-F.), Biomedical Research Institute Sant Pau, IIB Sant Pau, Spain; Institut und Poliklinik für Neuroradiologie (J.L.), Universitätsklinikum Carl Gustav Carus, Dresden; Department of Neuroradiology (J.L.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich; Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans); and German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans), Germany.

Objective: To investigate the prognostic relevance of cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA).

Methods: A total of 302 patients fulfilling clinical and imaging criteria for probable or possible CAA were enrolled into a prospective, multicenter cohort study and followed for 12 months. cSS was assessed on T2*/susceptibility-weighted imaging MRI. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006956DOI Listing
February 2019

Microangiopathy underlying mixed-location intracerebral hemorrhages/microbleeds: A PiB-PET study.

Neurology 2019 Feb 23;92(8):e774-e781. Epub 2019 Jan 23.

From the Department of Neurology (H.H.T.), National Taiwan University Hospital Bei-Hu Branch, Taipei; Departments of Neurology (H.H.T., L.-K.T., S.-C.T., J.-S.J.), Medical Imaging (Y.-F.C., B.-C.L.), and Nuclear Medicine (R.-F.Y.), National Taiwan University Hospital, Taipei; Department of Neurology (M.P., P.F., M.E.G.), Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA; Graduate Institute of Clinical Medicine (H.H.T.) and Division of Cardiology (C.-Y.H.), Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei.

Objective: To test the hypothesis that patients with concomitant lobar and deep intracerebral hemorrhages/microbleeds (mixed ICH) have predominantly hypertensive small vessel disease (HTN-SVD) rather than cerebral amyloid angiopathy (CAA), using in vivo amyloid imaging.

Methods: Eighty Asian patients with primary ICH without dementia were included in this cross-sectional study. All patients underwent brain MRI and C-Pittsburgh compound B (PiB)-PET imaging. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006953DOI Listing
February 2019
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Predictors of new remote cerebral microbleeds after IV thrombolysis for ischemic stroke.

Neurology 2019 Feb 23;92(7):e630-e638. Epub 2019 Jan 23.

From the Klinik und Hochschulambulanz für Neurologie (T.B.B., H.E., H.J.A., M.E., C.H.N., J.F.S.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (T.B.B., H.E., M.E., C.H.N., J.F.S.); Center for Stroke Research Berlin (T.B.B., K.V., G.T., J.B.F., H.J.A., M.E., C.H.N., J.F.S.), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (G.T.), Hôpital Sainte-Anne, Université Paris Descartes; INSERM U894 (G.T.), Paris, France; German Center for Cardiovascular Diseases (M.E., C.H.N., J.F.S.), partner site Berlin; German Center for Neurodegenerative Diseases (M.E.), partner site Berlin, Germany.

Objective: To assess the frequency, associated factors, and underlying vasculopathy of new remote cerebral microbleeds (CMB), as well as the risk of concomitant hemorrhagic complications related to new CMBs, after IV thrombolysis (IVT) in acute stroke patients.

Methods: We conducted an observational study using data from our local thrombolysis registry. We included consecutive stroke patients with MRI (3T)-based IVT and a follow-up MRI the next day between 2008 and 2017 (n = 396). Read More

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http://dx.doi.org/10.1212/WNL.0000000000006915DOI Listing
February 2019

Width of sulcus and thickness of gyrus in patients with cerebral atherosclerosis: a new tool for the prevention of vascular cognitive impairment.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):684-691

. PhD in Pathology, Professor of Postgraduate Course Health Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.

Background And Purpose: Cerebral atherosclerosis is the main cause of lesions that contribute to vascular cognitive impairment and vascular dementia, followed by arteriosclerosis of small vessels and cerebral amyloid angiopathy. The purpose of this study was to compare the post-mortem radiological alterations of autopsied adults with the macroscopic alterations in the posterior region of these brains in order to establish a relationship between the two forms of analysis and to discuss the relevance of the prevention of vascular cognitive impairment in patients with encephalic atherosclerosis.

Materials And Methods: Thirteen brains were analysed macroscopically to assess the degree of atherosclerosis of the basilar and the posterior cerebral arteries. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.64.08.684DOI Listing
August 2018
5 Reads

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study.

Alzheimers Res Ther 2019 Jan 22;11(1):11. Epub 2019 Jan 22.

Institute of Clinical Medicine, Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

Background: We developed multifactorial models for predicting incident dementia and brain pathology in the oldest old using the Vantaa 85+ cohort.

Methods: We included participants without dementia at baseline and at least 2 years of follow-up (N = 245) for dementia prediction or with autopsy data (N = 163) for pathology. A supervised machine learning method was used for model development, considering sociodemographic, cognitive, clinical, vascular, and lifestyle factors, as well as APOE genotype. Read More

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https://alzres.biomedcentral.com/articles/10.1186/s13195-018
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http://dx.doi.org/10.1186/s13195-018-0450-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343349PMC
January 2019
10 Reads

Chronic treatment with five vascular risk factors causes cerebral amyloid angiopathy but no Alzheimer pathology in C57BL6 mice.

Brain Behav Immun 2019 Jan 19. Epub 2019 Jan 19.

Laboratory of Psychiatry and Experimental Alzheimer's Research, Medical University of Innsbruck, Austria. Electronic address:

Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder and the most common form of dementia coming along with cerebral amyloid angiopathy (CAA) in more than 70% of all cases. However, CAA occurs also in pure form without AD pathology. Vascular life style risk factors such as obesity, hypertension, hypercholesterolemia, diabetes, stress or an old age play an important role in the progression of CAA. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.01.009DOI Listing
January 2019
3 Reads

Genetics of Vascular Cognitive Impairment.

Stroke 2019 Jan 21:STROKEAHA118020379. Epub 2019 Jan 21.

Department of Neurology, Medical University of Graz, Austria (R.S.).

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http://dx.doi.org/10.1161/STROKEAHA.118.020379DOI Listing
January 2019
1 Read

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy.

Stroke 2019 Feb;50(2):328-335

MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Charlestown (W.M.F., B.J.B., M.P.F., S.J.v.V.).

Background and Purpose- Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The pathophysiology of CAA and CAA-related bleeding remains poorly understood. In this postmortem study, we explored whether blood-brain barrier leakage is associated with CAA and microvascular lesions. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023788DOI Listing
February 2019
2 Reads

Anton's Syndrome associated with autotopagnosia.

Appl Neuropsychol Adult 2019 Jan 20:1-5. Epub 2019 Jan 20.

a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.

We describe an unusual case of a 68-year-old male affected by cerebral amyloid angiopathy and cortical blindness associated with Anton's syndrome. In addition, our patient presented with autotopagnosia, a form of agnosia characterized by loss of body spatial representation. Neuropsychological assessment evidenced cognitive impairment. Read More

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http://dx.doi.org/10.1080/23279095.2018.1538048DOI Listing
January 2019
4 Reads

Small Cortical Infarcts Transformed to Lobar Cerebral Microbleeds: A Case Series.

J Stroke Cerebrovasc Dis 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Cerebral microbleeds (MBs) have been often observed due to the development of imaging devices, and are classified to deep and lobar MBs. Lobar MBs are strongly associated with cerebral amyloid angiopathy. Here, we report 3 cases of lobar MBs that developed after small cortical ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.050DOI Listing
January 2019

Cerebral Amyloid Angiopathy Related İnflammation Presenting As Steroid Responsive Brain Mass.

Turk Neurosurg 2018 Sep 11. Epub 2018 Sep 11.

Yeditepe University Hospital.

Cerebral amyloid angiopathy (CAA) is a common but often asymptomatic disease, characterized by the deposition of amyloid proteins within brain parenchyma and leptomeningeal-cortical vessels. It can occur as a sporadic disorder or accompany Alzheimer disease (AD). The usual presantation of CAA is spontenous lobar hemorrage, Unlike CAA, cerebral amyloid angiopathy-related inflammation (CAA-ri),a subtype of CAA, can show different presentations and responds to steroid (or immunsupressive) treatment. Read More

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http://www.turkishneurosurgery.org.tr/summary_en_doi.php3?do
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http://dx.doi.org/10.5137/1019-5149.JTN.22592-18.3DOI Listing
September 2018
6 Reads

New Silent Cerebral Infarction in Patients with Acute Non-Cerebral Amyloid Angiopathy Intracerebral Hemorrhage as a Predictor of Recurrent Cerebrovascular Events.

Med Sci Monit 2019 Jan 14;25:418-426. Epub 2019 Jan 14.

Department of Laboratory Medicine, Shuyang People's Hospital, Shuyang Hospital Affiliated to Xuzhou Medical University, Shuyang, Jiangsu, China (mainland).

BACKGROUND The aim of this study was to investigate the incidence and related risk factors of new silent cerebral infarction in patients with acute non-cerebral amyloid angiopathy (non-CAA) intracerebral hemorrhage (ICH) and to explore clinical cerebrovascular event recurrence within 1 year. MATERIAL AND METHODS This prospective study observed 152 patients with non-CAA ICH diagnosed by computed tomography within 3 days after onset. All patients underwent magnetic resonance imaging on day 14 to identify silent cerebral infarction, and their subsequent clinical cerebrovascular events were followed up regularly within 1 year. Read More

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https://www.medscimonit.com/abstract/index/idArt/914423
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http://dx.doi.org/10.12659/MSM.914423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342061PMC
January 2019
3 Reads

Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage.

J Neurol 2019 Mar 8;266(3):625-630. Epub 2019 Jan 8.

Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, #300, Boston, MA, 02114, USA.

Background: Spontaneous cerebellar-intracerebral hemorrhage (ICH) can be associated with both cerebral amyloid angiopathy (CAA) and hypertensive small vessel disease (HTN-SVD, i.e. arteriolosclerosis). Read More

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http://dx.doi.org/10.1007/s00415-018-09177-wDOI Listing
March 2019
2 Reads

Cerebrovascular pathology in cerebral amyloid angiopathy presenting as intracerebral haemorrhage.

Virchows Arch 2019 Feb 7;474(2):235-245. Epub 2019 Jan 7.

Department of Neuropathology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, Karnataka, 560029, India.

Cerebral amyloid angiopathy (CAA) is the second most common cause of non-traumatic intracerebral haemorrhage (ICH) accounting for 12-15% of lobar haemorrhages in the elderly. Definitive diagnosis of CAA requires histological evaluation. We aimed to evaluate the spectrum of cerebrovascular changes in CAA-related ICH. Read More

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http://dx.doi.org/10.1007/s00428-018-2505-zDOI Listing
February 2019
4 Reads

Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid.

J Cereb Blood Flow Metab 2019 Jan 7:271678X18822474. Epub 2019 Jan 7.

Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN, USA.

Cerebral amyloid angiopathy (CAA) is present in over half of the elderly population and in 80-90% of Alzheimer's disease (AD) patients. CAA is defined by the deposition of beta amyloid (Aβ) in small cerebral arteries and capillaries. Cardiovascular risk factors are associated with an increased incidence of CAA. Read More

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http://dx.doi.org/10.1177/0271678X18822474DOI Listing
January 2019

Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura.

Ann Neurol 2019 Feb 17;85(2):284-290. Epub 2019 Jan 17.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London.

Amyloid-β transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-β seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Read More

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http://doi.wiley.com/10.1002/ana.25407
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http://dx.doi.org/10.1002/ana.25407DOI Listing
February 2019
5 Reads

Cerebral Amyloid Angiopathy and Neuritic Plaque Pathology Correlate with Cognitive Decline in Elderly Non-Demented Individuals.

J Alzheimers Dis 2019 ;67(1):411-422

Department of Neurobiology, Barrow Neurological Institute, Phoenix, AZ, USA.

Background: Cerebral amyloid angiopathy (CAA) is a vascular neuropathology commonly reported in non-cognitively impaired (NCI), mild cognitive impairment, and Alzheimer's disease (AD) brains. However, it is unknown whether similar findings are present in non-demented elderly subjects.

Objective: This study determined the association between CAA and cognition among elderly NCI subjects with varying levels of AD pathology. Read More

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http://dx.doi.org/10.3233/JAD-180765DOI Listing
January 2019
1 Read

Biopsy During Minimally Invasive Intracerebral Hemorrhage Clot Evacuation.

World Neurosurg 2018 Dec 24. Epub 2018 Dec 24.

Department of Neurosurgery, Mount Sinai Hospital, New York, New York, USA. Electronic address:

Background: The safety and efficacy of brain parenchyma biopsy during minimally invasive (MIS) intracerebral hemorrhage (ICH) clot evacuation has not been previously reported. The objective of this study was to establish the safety and diagnostic efficacy of brain biopsy during MIS ICH clot evacuation and to validate the modified Boston criteria as a predictor of cerebral amyloid angiopathy (CAA) in this cohort.

Methods: From October 2016 to March 2018, superficial and perihematomal biopsies were collected for 40 patients undergoing MIS ICH clot evacuation and analyzed by the pathology department to assess for various ICH etiologies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183288
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http://dx.doi.org/10.1016/j.wneu.2018.12.058DOI Listing
December 2018
10 Reads

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy.

J Vis Exp 2018 Nov 30(141). Epub 2018 Nov 30.

Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, Rockefeller University;

This article presents methods for generating in vitro fibrin clots and analyzing the effect of beta-amyloid (Aβ) protein on clot formation and structure by spectrometry and scanning electron microscopy (SEM). Aβ, which forms neurotoxic amyloid aggregates in Alzheimer's disease (AD), has been shown to interact with fibrinogen. This Aβ-fibrinogen interaction makes the fibrin clot structurally abnormal and resistant to fibrinolysis. Read More

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http://dx.doi.org/10.3791/58475DOI Listing
November 2018
1 Read

Diffusion-Weighted Imaging Hyperintensities in Subtypes of Acute Intracerebral Hemorrhage.

Stroke 2018 Dec 7:STROKEAHA118021407. Epub 2018 Dec 7.

From the Normandie University, UNICAEN, Inserm U1237, Caen, France (M.B., M.Z., E.T.).

Background and Purpose- Diffusion-weighted imaging (DWI) hyperintensities in intracerebral hemorrhage (ICH) are associated with increased risk of recurrent ICH, cognitive impairment, and death, but whether these lesions are specific to a subtype of ICH remains uncertain. We investigated the association between DWI lesions and ICH subtype and explored the risk factors for DWI lesions. Methods- In a systematic review of ICH studies, we identified those reporting prevalence of DWI lesions. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.021407
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http://dx.doi.org/10.1161/STROKEAHA.118.021407DOI Listing
December 2018
8 Reads

Ambient Pollutants and Spontaneous Intracerebral Hemorrhage in Greater Boston.

Stroke 2018 Oct 18:2764-2766. Epub 2018 Oct 18.

Department of Neurology, Massachusetts General Hospital, Boston, MA (A.W., A.C., A.V.).

Background and Purpose- Associations between exposures to ambient air pollution and spontaneous intracerebral hemorrhage (ICH) have been inconsistent, and data on stroke subtypes are currently limited. Methods- We obtained information on all cases of deep or lobar hematomas from ICH patients who were admitted to the Massachusetts General Hospital in Boston, MA, between 2006 and 2011. We linked the date of admission with 1- to 7-day moving averages of fine particulate matter (PM), black carbon, nitrogen dioxide, and ozone from area monitors. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023128DOI Listing
October 2018
6 Reads

Acute convexity subarachnoid hemorrhage: what the neurosurgeon needs to know.

World Neurosurg 2018 Dec 20. Epub 2018 Dec 20.

Stroke Research Centre, University College London, Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2018.12.062DOI Listing
December 2018

Perioperative Cerebral Microbleeds After Adult Cardiac Surgery.

Stroke 2019 Feb;50(2):336-343

From the Department of Cardiovascular Sciences, University of Leicester, United Kingdom (N.P., J.J., M.A.H., L.C., E.M.L.C.).

Background and Purpose- Cerebral microbleeds (CMBs) have been observed using magnetic resonance imaging in patients with cardiovascular risk factors, cognitive deterioration, small vessel disease, and dementia. They are a well-known consequence of cerebral amyloid angiopathy, chronic hypertension, and diffuse axonal injury, among other causes. However, the frequency and location of new CMBs postadult cardiac surgery, in association with cognition and perioperative risk factors, have yet to be studied. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023355
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http://dx.doi.org/10.1161/STROKEAHA.118.023355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354910PMC
February 2019
7 Reads

Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies.

Acta Neuropathol Commun 2018 Dec 19;6(1):142. Epub 2018 Dec 19.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA.

TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific anatomic regions. To examine the comorbidities associated with TDP-43 pathology in aged individuals, we studied data from the National Alzheimer's Coordinating Center (NACC) Neuropathology Data Set. Read More

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http://dx.doi.org/10.1186/s40478-018-0641-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299605PMC
December 2018
2 Reads

Acute ischaemic lesions are associated with cortical superficial siderosis in spontaneous intracerebral hemorrhage.

Eur J Neurol 2018 Nov 22. Epub 2018 Nov 22.

Neurology Department, Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse, Toulouse.

Background And Purpose: Diffusion-weighted imaging (DWI) commonly detects acute ischaemic lesions in patients with acute intracerebral hemorrhage (ICH), especially with cerebral amyloid angiopathy (CAA). We investigated the relationship between cortical superficial siderosis (cSS), a neuroimaging marker of CAA, and DWI lesions in patients with acute ICH.

Methods: We conducted a retrospective analysis of prospectively collected data from consecutive patients with acute supratentorial ICH who underwent brain magnetic resonance imaging within 10 days after symptom onset. Read More

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http://dx.doi.org/10.1111/ene.13874DOI Listing
November 2018
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Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy.

Clin Neurol Neurosurg 2019 Jan 29;176:110-115. Epub 2018 Nov 29.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.

Objective: To evaluate the clinical and histopathological features of elderly patients with subcortical intracerebral hemorrhage (ICH), and to analyze the presence of cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD) type pathologic changes using amyloid beta (Aβ) and tau immunohistochemistry.

Patients And Methods: We retrospectively analyzed cases satisfying the Boston criteria for CAA among patients with subcortical hemorrhage who underwent surgical removal by craniotomy at our hospital. Surgical specimens were subjected to hematoxylin and eosin (HE) staining as well as immunostaining. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.11.020DOI Listing
January 2019
2 Reads

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

Nature 2018 12 13;564(7736):415-419. Epub 2018 Dec 13.

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.

We previously reported the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt-Jakob disease (CJD) who had been treated during childhood with human cadaveric pituitary-derived growth hormone (c-hGH) contaminated with prions. The marked deposition of parenchymal and vascular Aβ in these relatively young individuals with treatment-induced (iatrogenic) CJD (iCJD), in contrast to other prion-disease patients and population controls, allied with the ability of Alzheimer's disease brain homogenates to seed Aβ deposition in laboratory animals, led us to argue that the implicated c-hGH batches might have been contaminated with Aβ seeds as well as with prions. However, this was necessarily an association, and not an experimental, study in humans and causality could not be concluded. Read More

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http://www.nature.com/articles/s41586-018-0790-y
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http://dx.doi.org/10.1038/s41586-018-0790-yDOI Listing
December 2018
34 Reads

Subarachnoid extension of lobar hemorrhage on acute/subacute MRI is associated with cerebral amyloid angiopathy criteria.

Acta Neurol Belg 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to analyze SAHE on MRI in the acute and subacute phase of LH in patients with and without associated hemorrhagic features supportive of CAA (i. Read More

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http://dx.doi.org/10.1007/s13760-018-01060-9DOI Listing
December 2018
1 Read

Successful mechanical thrombectomy in stroke with thrombolysis-associated intracerebral hemorrhage-a case report.

J Stroke Cerebrovasc Dis 2019 Feb 24;28(2):285-287. Epub 2018 Oct 24.

Department of Neurology, University Hospital Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. Electronic address:

Background: Intravenous thrombolysis and mechanical thrombectomy are the standard of care for patients with acute ischemic stroke with large vessel occlusion. Intracerebral hemorrhage is a main complication of intravenous thrombolysis, however, no data are available on the efficacy and safety of mechanical thrombectomy in patients with thrombolysis-associated intracerebral hemorrhage. This constellation is expected to become more frequent as increasing numbers of patients are treated under the drip-and-ship paradigm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183056
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.045DOI Listing
February 2019
5 Reads
1.993 Impact Factor

Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases.

J Autoimmun 2019 Feb 24;97:22-28. Epub 2018 Oct 24.

Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Objective: To describe the clinical, laboratory, and imaging features and course of patients with primary central nervous system vasculitis (PCNSV) presenting with an intracranial tumor-like mass (TLM).

Methods: We retrospectively studied a cohort of 191 consecutive patients with PCNSV seen at the Mayo Clinic, Rochester, MN over a 35-year period (1982-2017). 13/191 patients presented with a TLM. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.001DOI Listing
February 2019
1 Read

Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke.

Angiogenesis 2018 Dec 5. Epub 2018 Dec 5.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 6309 MBRB, Chapel Hill, NC, 27599-7545, USA.

Vascular dysfunction contributes to the progression and severity of Alzheimer's disease (AD). Patients with AD also sustain larger infarctions after ischemic stroke; however, the responsible mechanisms are unknown. Pial collaterals are the primary source of protection in stroke. Read More

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http://dx.doi.org/10.1007/s10456-018-9655-0DOI Listing
December 2018
3 Reads
4.876 Impact Factor

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Institute of Biomedical and Clinical Sciences (IBCS), College of Medicine and Health (CMH), St. Luke's Campus, University of Exeter, Exeter EX4 4QL, UK.

For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91 and was considered to be a peculiarity of professional phagocytic cells. Over the last decade, several more homologs have been identified and based on current research, the NOX family consists of NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1 and DUOX2 enzymes. NOXs are electron transporting membrane proteins that are responsible for reactive oxygen species (ROS) generation-primarily superoxide anion (O₂), although hydrogen peroxide (H₂O₂) can also be generated. Read More

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http://www.mdpi.com/1422-0067/19/12/3824
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http://dx.doi.org/10.3390/ijms19123824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321244PMC
November 2018
14 Reads

Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: a neuropathological study.

Folia Neuropathol 2018 ;56(2):81-87

Introduction: The prevalence of dementia is increasing in our aging population. Because of the complexity of disease pathology, dementia classifications remain controversial. The present post-mortem study investigates whether there are age differences between dementia brains with a single pure neurodegenerative or cerebrovascular disease and those with mixed pathological features. Read More

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http://dx.doi.org/10.5114/fn.2018.76610DOI Listing
January 2018
2 Reads

The cAMP/PKA Pathway Inhibits Beta-amyloid Peptide Release from Human Platelets.

Neuroscience 2019 01 26;397:159-171. Epub 2018 Nov 26.

Thrombosis Reasearch Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Chile; Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca 3460000, Chile; Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, R09I2001 Talca, Chile. Electronic address:

The main component of Alzheimer's disease (AD) is the amyloid-beta peptide (Aβ), the brain of these patients is characterized by deposits in the parenchyma and cerebral blood vessels known as cerebral amyloid angiopathy (CAA). On the other hand, the platelets are the major source of the Aβ peptide in circulation and once secreted can activate the platelets and endothelial cells producing the secretion of several inflammatory mediators that finally end up unchaining the CAA and later AD. In the present study we demonstrate that cAMP/PKA pathway plays key roles in the regulation of calpain activation and secretion of Aβ in human platelets. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.11.025DOI Listing
January 2019
8 Reads

Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease.

Brain Pathol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.

The blood-brain barrier (BBB) regulates cerebrovascular permeability and leakage of blood-derived fibrinogen. Dysfunction of the BBB has been associated with cerebral arteriolosclerosis small vessel disease (SVD) and white matter lesions (WML). Furthermore, BBB dysfunction is associated with the pathogenesis of Alzheimer's disease (AD) with the presence of CSF plasma proteins suggested to be a potential biomarker of AD. Read More

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http://dx.doi.org/10.1111/bpa.12685DOI Listing
November 2018
5 Reads

Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage.

Front Neurol 2018 12;9:926. Epub 2018 Nov 12.

Department of Neurology, Center for Neuroscience, Donders Institute for Brain Cognition & Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.

Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous intracerebral hemorrhage due to cerebral small vessel disease. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00926
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http://dx.doi.org/10.3389/fneur.2018.00926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240684PMC
November 2018
7 Reads

Multiple infarcts and hemorrhages in the central nervous system of a dog with cerebral amyloid angiopathy: a case report.

BMC Vet Res 2018 Nov 27;14(1):370. Epub 2018 Nov 27.

Departament of Pathology, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, São Paulo, 05508-270, Brazil.

Background: β-amyloid (Aβ) can accumulate in the brain of aged dogs, and within vessels walls, the disease is called cerebral amyloid angiopathy (CAA). In humans, Alzheimer's disease and CAA are strongly correlated with cerebrovascular disease. However, in dogs, this association has not been extensively studied yet. Read More

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http://dx.doi.org/10.1186/s12917-018-1700-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258392PMC
November 2018
1 Read

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy.

Brain 2018 Dec;141(12):3377-3388

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, The Netherlands.

Increasing evidence suggests that vascular dysfunction in the brain is associated with early stages of Alzheimer's disease. Amyloid-β deposition in the microvasculature of the brain, a process referred to as capillary cerebral amyloid angiopathy (capillary CAA), propagates vascular remodelling, which results in impaired function of the blood-brain barrier, reduced cerebral perfusion and increased hypoxia. While improving vascular function may be an attractive new way to fight capillary CAA, the underlying factors that mediate vascular alterations in Alzheimer's disease and capillary CAA pathogenesis remain largely unknown. Read More

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http://dx.doi.org/10.1093/brain/awy274DOI Listing
December 2018
15 Reads