2,995 results match your criteria Cerebral Amyloid Angiopathy


Authors' Response to "Barometric Pressure in Cerebral Amyloid Angiopathy: A Pressure to Bleed?"

J Stroke Cerebrovasc Dis 2019 Apr 19. Epub 2019 Apr 19.

University of Illinois at Chicago, Department of Earth and Environmental Sciences, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.022DOI Listing

Topographic distribution of white matter changes and lacunar infarcts in neurodegenerative and vascular dementia syndromes: A post-mortem 7.0-tesla magnetic resonance imaging study.

Eur Stroke J 2016 Jun 18;1(2):122-129. Epub 2016 May 18.

Université Lille 2, INSERM U 1171, Lille, France.

Background: White matter changes and lacunar infarcts are regarded as linked to the same underlying small-vessel pathology. On magnetic resonance imaging, white matter changes are frequently observed, while the number of lacunar infarcts is probably underestimated. The present study post-mortem 7. Read More

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http://dx.doi.org/10.1177/2396987316650780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301232PMC

Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Neuroradiology, University Medical Center Freiburg, Germany.

Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193020
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http://dx.doi.org/10.1016/j.brainres.2019.04.014DOI Listing
April 2019
2 Reads

Susceptibility Weighted Imaging (SWI) Recommended as a Regular Magnetic Resonance Diagnosis for Vascular Dementia to Identify Independent Idiopathic Normal Pressure Hydrocephalus Before Ventriculo-Peritoneal (V-P) Shunt Treatment: A Case Study.

Front Neurol 2019 29;10:262. Epub 2019 Mar 29.

Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.

Idiopathic normal pressure hydrocephalus (INPH) with comorbid vascular dementia (VD) often have poor response to ventriculo-peritoneal (V-P) shunt. Here, three patients over the age of 60 came to the hospital with the similar clinical symptoms, Evan index over 0.3, mini-mental state examination (MMSE) score <27, and cerebrospinal fluid (CSF) pressure under 200 mmHO. Read More

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http://dx.doi.org/10.3389/fneur.2019.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449466PMC
March 2019
1 Read

Risk Aversion and Alzheimer Disease in Old Age.

Am J Geriatr Psychiatry 2019 Feb 21. Epub 2019 Feb 21.

Behavioral Sciences (RSW, PAB).

Objective: To test the hypothesis that late-life risk aversion is partly a prodromal sign of dementia.

Methods: The authors' design was a longitudinal clinical-pathologic cohort study. The setting included participants' residences in the Chicago area, and a total of 874 older persons without dementia were enrolled. Read More

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http://dx.doi.org/10.1016/j.jagp.2019.02.011DOI Listing
February 2019
1 Read

Clinical, neuropathological and genetic features of Lewy body dementias.

Neuropathol Appl Neurobiol 2019 Apr 12. Epub 2019 Apr 12.

Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London.

Lewy body dementias are the second most common neurodegenerative dementias after Alzheimer's disease, and include dementia with Lewy bodies and Parkinson's disease dementia. They share similar clinical and neuropathological features but differ in the time of dementia and parkinsonism onset. Although Lewy bodies are their main pathological hallmark, several studies have shown the emerging importance of Alzheimer's disease pathology. Read More

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http://dx.doi.org/10.1111/nan.12554DOI Listing
April 2019
1 Read

Partial Identification of Amyloid-β Degrading Activity in Human Serum.

Nagoya J Med Sci 2019 Feb;81(1):55-64

Laboratory of Radiation Safety, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.

The major hallmarks of Alzheimer's disease (AD) are the extracellular accumulation of pathological amyloid beta (Aβ) in the brain parenchyma and Aβ deposition in cerebral blood walls (cerebral amyloid angiopathy; CAA). Although CAA occurs in more than 80% of AD patients, the mechanisms of Aβ deposition and clearance around the vessel walls are unknown. We found Aβ-degrading activity in human serum during analysis of the regulatory mechanism of Aβ production in human endothelial cells. Read More

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http://dx.doi.org/10.18999/nagjms.81.1.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433627PMC
February 2019
2 Reads

Sex as a biological variable in the pathology and pharmacology of neurodegenerative and neurovascular diseases.

Br J Pharmacol 2019 Apr 4. Epub 2019 Apr 4.

University of Texas McGovern Medical School, Department of Neurology, Fannin Street, Houston, TX, 77030.

The incidence of dementia, most commonly caused by cerebrovascular and neurodegenerative diseases, continues to grow as our population ages. Alzheimer disease (AD) and vascular cognitive impairment (VCI) are responsible for more than 80% of all cases of dementia. There are few effective, long-term treatments for AD and VCI-related conditions (e. Read More

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http://dx.doi.org/10.1111/bph.14675DOI Listing
April 2019
1 Read

HDL from an Alzheimer's disease perspective.

Curr Opin Lipidol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology and Laboratory Medicine.

Purpose Of Review: We review current knowledge regarding HDL and Alzheimer's disease, focusing on HDL's vasoprotective functions and potential as a biomarker and therapeutic target for the vascular contributions of Alzheimer's disease.

Recent Findings: Many epidemiological studies have observed that circulating HDL levels associate with decreased Alzheimer's disease risk. However, it is now understood that the functions of HDL may be more informative than levels of HDL cholesterol (HDL-C). Read More

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http://dx.doi.org/10.1097/MOL.0000000000000604DOI Listing
April 2019
2 Reads

Convexal subarachnoid hemorrhage and acute ischemic stroke: a border zone matter?

Neurol Sci 2019 Apr 2. Epub 2019 Apr 2.

Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70100, Bari, Italy.

Background: Convexal subarachnoid hemorrhage (c-SAH) is an infrequent condition with variable causes. c-SAH concomitant to acute ischemic stroke (AIS) is even less frequent, and the relationship between the two conditions remains unclear.

Methods: Between January 2016 and January 2018, we treated four patients who were referred to our stroke unit with ischemic stroke and concomitant nontraumatic c-SAH. Read More

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http://dx.doi.org/10.1007/s10072-019-03868-6DOI Listing
April 2019
2 Reads

Clinical significance of amyloid β positivity in patients with probable cerebral amyloid angiopathy markers.

Eur J Nucl Med Mol Imaging 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Purpose: We investigated the frequency and clinical significance of amyloid β (Aβ) positivity on PET in patients with cerebral amyloid angiopathy (CAA).

Methods: We recruited 65 patients who met the modified Boston criteria for probable CAA. All underwent amyloid PET, MRI, APOE genotyping and neuropsychological testing, and we obtained information on MRI markers of CAA and ischemic cerebral small-vessel disease (CSVD). Read More

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http://dx.doi.org/10.1007/s00259-019-04314-7DOI Listing
April 2019
3 Reads

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy.

Front Neurol 2019 13;10:187. Epub 2019 Mar 13.

Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Cerebral amyloid angiopathy (CAA) is a common cause of lobar intracerebral hemorrhage (ICH) in elderly individuals and it is the result of the cerebrovascular deposition of beta-amyloid (Aβ) protein. CAA is frequently found in patients with Alzheimer's disease (AD), although it has an independent contribution to the cognitive deterioration associated with age. Specific apolipoproteins (Apo) have been associated with Aβ fibrillization and clearance from the brain. Read More

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http://dx.doi.org/10.3389/fneur.2019.00187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424885PMC
March 2019
2 Reads

Anterior Cranial Fossa Dural Arteriovenous Fistula Presenting as Recurrent Multifocal Lobar Intracerebral Hemorrhages: A Case Report.

Neurohospitalist 2019 Apr 4;9(2):109-112. Epub 2018 Sep 4.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

We report a unique case and presentation of a 77-year-old man with atrial fibrillation who presented with complex imaging features, including bifrontal cerebral hematomas that progressed to multifocal macro- and microhemorrhages, vasogenic edema, and cortical/meningeal enhancement. Cerebrospinal fluid analysis was only remarkable for a protein elevation of 65 mg/dL. Leptomeningeal vessel biopsy failed to demonstrate evidence of amyloid angiopathy but did show concentric obstructive intimal fibroplasia, suggestive of chronic venous congestion. Read More

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http://dx.doi.org/10.1177/1941874418797797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429676PMC
April 2019
1 Read

Barometric Pressure in Cerebral Amyloid Angiopathy: A Pressure to Bleed?

J Stroke Cerebrovasc Dis 2019 Mar 22. Epub 2019 Mar 22.

Department of Neurology, Mayo Clinic Jacksonville, Florida.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.039DOI Listing
March 2019
2 Reads

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.

J Vis Exp 2019 Mar 7(145). Epub 2019 Mar 7.

Graduate School of Brain Science, Doshisha University.

The neuropathology of Alzheimer's disease (AD) is characterized by the accumulation and aggregation of amyloid β (Aβ) peptides into extracellular plaques of the brain. The Aβ peptides, composed of 40 amino acids, are generated from amyloid precursor proteins (APP) by β- and γ-secretases. Aβ is deposited not only in cerebral parenchyma but also in leptomeningeal and cerebral vessel walls, known as cerebral amyloid angiopathy (CAA). Read More

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http://dx.doi.org/10.3791/57645DOI Listing
March 2019
3 Reads

Sporadic cerebral amyloid angiopathy.

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(1):73-82

Service de neurologie et pathologie neurovasculaire, Clinique neurologique, Hôpital Roger Salengro, Lille, France.

Sporadic cerebral amyloid angiopathy (CAA) is a small vessel disease caused by vascular deposits of Aß-amyloid peptides in the walls of cortical and leptomeningeal vessels. Advancing age is the strongest known clinical risk factor for developing CAA. This devastating disease occurs frequently in elderly people, and is a frequent cause of symptomatic lobar intracerebral hemorrhage (ICH), cognitive impairment and transient focal neurological episodes. Read More

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http://dx.doi.org/10.1684/pnv.2018.0776DOI Listing
March 2019
2 Reads

Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer's Disease.

Curr Alzheimer Res 2019 Mar 21. Epub 2019 Mar 21.

Division of Neurotoxicology National Center for Toxicological Research, CDER/FDA, White Oak, MD-20993. United States.

Background: Alzheimer's disease (AD) is the most common type of dementia characterized by amyloid plaques containing amyloid beta (Aβ) peptides and neurofibrillary tangles containing tau protein. In addition to neuronal loss, cerebral amyloid angiopathy (CAA) commonly occurs in AD. CAA is characterized by Aβ deposition in brain microvessels. Read More

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http://dx.doi.org/10.2174/1567205016666190321155422DOI Listing
March 2019
14 Reads
3.889 Impact Factor

Characteristics of Cerebral Microbleeds.

Dement Neurocogn Disord 2018 Sep 6;17(3):73-82. Epub 2018 Dec 6.

Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Cerebral microbleeds (CMBs) are increasingly recognized neuroimaging findings, occurring with cerebrovascular disease, dementia, and aging. CMBs are associated with subsequent hemorrhagic and ischemic stroke, and also with an increased risk of cognitive deterioration and dementia. They occur in the setting of impaired small vessel integrity due to hypertension or cerebral amyloid angiopathy. Read More

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http://dx.doi.org/10.12779/dnd.2018.17.3.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428007PMC
September 2018
1 Read

Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease: A 7 Tesla MRI study.

J Cereb Blood Flow Metab 2019 Mar 19:271678X19838087. Epub 2019 Mar 19.

1 Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, the Netherlands.

MRI-visible perivascular spaces (PVS) in the semioval centre are associated with cerebral amyloid angiopathy (CAA), but it is unknown if PVS co-localize with MRI markers of CAA. To examine this, we assessed the topographical association between cortical cerebral microbleeds (CMBs) - as an indirect marker of CAA - and dilatation of juxtacortical perivascular spaces (jPVS) in 46 patients with amnestic mild cognitive impairment (aMCI) or early Alzheimer's disease (eAD). The degree of dilatation of jPVS <1 cm around each cortical CMBs was compared with a similar reference site (no CMB) in the contralateral hemisphere, using a 4-point scale. Read More

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http://dx.doi.org/10.1177/0271678X19838087DOI Listing
March 2019
4 Reads

Neurodegenerative Diseases and Ageing.

Subcell Biochem 2019;91:75-106

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

This chapter describes the main neuropathological features of the most common age associated neurodegenerative diseases including Alzheimer's disease, Lewy body diseases, vascular dementia and the various types of frontotemporal lobar degeneration. In addition, the more recent concepts of primary age-related tauopathy and ageing-related tau astrogliopathy as well as chronic traumatic encephalopathy are briefly described. One section is dedicated to cerebral multi-morbidity as it is becoming increasingly clear that the old brain is characterised by the presence of multiple pathologies (to varying extent) rather than by one single, disease specific pathology alone. Read More

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http://dx.doi.org/10.1007/978-981-13-3681-2_4DOI Listing
January 2019
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Cortical Superficial Siderosis Evolution.

Stroke 2019 Apr;50(4):954-962

From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (A.C., G.B., L.X., M.P., D.R., A.A., K.M.S., J.R., M.E.G., A.V., S.M.G.).

Background and Purpose- We investigated cortical superficial siderosis (cSS) progression and its clinical relevance for incident lobar intracerebral hemorrhage (ICH) risk, in probable cerebral amyloid angiopathy presenting with neurological symptoms and without ICH at baseline. Methods- Consecutive patients meeting modified Boston criteria for probable cerebral amyloid angiopathy from a single-center cohort who underwent magnetic resonance imaging (MRI) at baseline and during follow-up were analyzed. cSS progression was assessed by comparison of the baseline and follow-up images. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433512PMC
April 2019
3 Reads
5.723 Impact Factor

Osteopontin and phospho-SMAD2/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy.

Brain Pathol 2019 Mar 13. Epub 2019 Mar 13.

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

In severe forms of cerebral amyloid angiopathy (CAA) pathology, vascular calcification has been observed in the cerebral cortex, both in vivo on MRI and CT, and post-mortem using histopathology. However, the pathomechanisms leading to calcification of CAA-laden arteries are unknown. Therefore, we investigated the correlation between calcification of cortical arterioles and several potential modulators of vascular calcification using immunohistochemistry in a unique collection of brain material of patients with a hereditary form of CAA, namely hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D or D-CAA). Read More

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http://dx.doi.org/10.1111/bpa.12721DOI Listing
March 2019
5 Reads

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue.

Acta Neuropathol Commun 2019 Mar 11;7(1):37. Epub 2019 Mar 11.

Department of Neurology, Massachusetts General Hospital, WACC, Suite 715, 15th Parkman St., Boston, MA, 02114, USA.

[F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of Alzheimer disease. We have examined regional and substrate-specific binding patterns as well as possible off-target binding of this tracer on human brain tissue to advance towards its validation. We applied [F-18]-MK-6240 phosphor screen and high resolution autoradiography to postmortem samples from patients with a definite pathological diagnosis of Alzheimer disease, frontotemporal lobar degeneration-tau (Pick's disease, progressive supranuclear palsy and corticobasal degeneration), chronic traumatic encephalopathy, frontotemporal lobar degeneration-Tar DNA-binding protein 43 (TDP-43), dementia with Lewy bodies, cerebral amyloid angiopathy and elderly controls free of pathologic changes of neurodegenerative disease. Read More

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0686-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410510PMC
March 2019
8 Reads

Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or  TIA.

J Neurol 2019 May 7;266(5):1250-1259. Epub 2019 Mar 7.

Department of Brain Repair and Rehabilitation, Stroke Research Centre, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, Russell Square House, 10-12 Russell Square, London, WC1B 5EH, UK.

Post-stroke dementia is common but has heterogenous mechanisms that are not fully understood, particularly in patients with atrial fibrillation (AF)-related ischaemic stroke or TIA. We investigated the relationship between MRI small-vessel disease markers (including a composite cerebral amyloid angiopathy, CAA, score) and cognitive trajectory over 12 months. We included patients from the CROMIS-2 AF study without pre-existing cognitive impairment and with Montreal Cognitive Assessment (MoCA) data. Read More

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http://dx.doi.org/10.1007/s00415-019-09256-6DOI Listing
May 2019
3 Reads

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology.

J Biol Chem 2019 Feb 27. Epub 2019 Feb 27.

Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden.

Amyloid-β (Aβ) pathology in Alzheimer's disease (AD) is characterized by the formation of polymorphic deposits comprising diffuse and cored plaques. Since diffuse plaques are predominantly observed in cognitively unaffected, amyloid positive (CU-AP) individuals, pathogenic conversion into cored plaques appears to be critical to AD pathogenesis. Herein, we identified the distinct Aβ species associated with amyloid polymorphism in brain tissue from individuals with sporadic AD (s-AD) and CU-AP. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006604DOI Listing
February 2019
3 Reads

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy.

Acta Neuropathol Commun 2019 Feb 26;7(1):26. Epub 2019 Feb 26.

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. Currently, there is no clear understanding of the mechanisms underlying the contribution of CAA to neurodegeneration. Despite the fact that CAA is highly associated with accumulation of Aβ, other types of amyloids have been shown to associate with the vasculature. Read More

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http://dx.doi.org/10.1186/s40478-019-0680-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390363PMC
February 2019
2 Reads

A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease.

Neurosci Lett 2019 May 23;701:125-131. Epub 2019 Feb 23.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Cerebral amyloid angiopathy (CAA) is a type of vascular disease present in more than 50% of demented elderly and more than 80% of Alzheimer's disease (AD) patients. Both CAA and AD are characterized by extracellular Aβ deposits with the distinction that CAA has vascular deposits while AD has amyloid plaques. In this study, we used immunoprecipitation (IP) in combination with mass spectrometry (MS) to test the hypothesis that the Aβ peptide pattern differs between subjects having Aβ plaque pathology only and subjects with Aβ plaque pathology together with CAA pathology. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.033DOI Listing
May 2019
2 Reads

Multiple Cerebral Hemorrhagic Lesions Depicted by Susceptibility-Weighted Imaging in a Patient with Down Syndrome: Case Report.

J Stroke Cerebrovasc Dis 2019 May 20;28(5):e37-e38. Epub 2019 Feb 20.

Department of Neurosurgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.

Our objective is to study a 53-year-old woman with Down syndrome presented with massive lobar hematoma in the left fronto-parietal lobe, and who underwent craniotomy and hematoma evacuation. Histopathological diagnosis of surgical specimen was amyloid angiopathy. Postoperative magnetic resonance studies were performed. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.024DOI Listing
May 2019
1 Read

Intranasal Losartan Decreases Perivascular Beta Amyloid, Inflammation, and the Decline of Neurogenesis in Hypertensive Rats.

Neurotherapeutics 2019 Feb 22. Epub 2019 Feb 22.

Department of Clinical Pharmacology, University Hospital of Tuebingen, Auf der Morgenstelle 8, 72076, Tuebingen, Germany.

The contribution of the local angiotensin receptor system to neuroinflammation, impaired neurogenesis, and amyloid beta (Aβ) accumulation in Alzheimer's disease (AD) and in hypertension is consistent with the remarkable neuroprotection provided by angiotensin receptor blockers (ARBs) independent of their blood pressure-lowering effect. Considering the causal relationship between hypertension and AD and that targeting cerebrovascular pathology with ARBs does not necessarily require their systemic effects, we tested intranasal losartan in the rat model of chronic hypertension (spontaneously hypertensive stroke-prone rats, SHRSP). Intranasal losartan at a subdepressor dose decreased mortality, neuroinflammation, and perivascular content of Aβ by enhancing key players in its metabolism and clearance, including insulin-degrading enzyme, neprilysin, and transthyretin. Read More

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http://dx.doi.org/10.1007/s13311-019-00723-6DOI Listing
February 2019
4 Reads

The Impact of Cerebral Amyloid Angiopathy in Various Neurodegenerative Dementia Syndromes: A Neuropathological Study.

Authors:
Jacques De Reuck

Neurol Res Int 2019 16;2019:7247325. Epub 2019 Jan 16.

Université de Lille 2, INSERM U1171, "Degenerative & Vascular Cognitive Disorders", CHU Lille, 59000, France.

Purpose: The Boston criteria for cerebral amyloid angiopathy (CAA) have to be confirmed by postmortem examination. The present study investigates the incidence and the cerebrovascular impact of the severity of CAA in various neurodegenerative dementia diseases.

Material And Methods: 208 patients underwent an autopsy. Read More

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http://dx.doi.org/10.1155/2019/7247325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354160PMC
January 2019
9 Reads

Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: Large prospective cohort and preliminary meta-analysis.

Int J Stroke 2019 Feb 20:1747493019830065. Epub 2019 Feb 20.

1 Department of Neurology, Hemorrhagic Stroke Research Program, JPK Stroke Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Background: We aimed to investigate cortical superficial siderosis as an MRI predictor of lobar intracerebral hemorrhage (ICH) recurrence risk in cerebral amyloid angiopathy (CAA), in a large prospective MRI cohort and a systematic review.

Methods: We analyzed a single-center MRI prospective cohort of consecutive CAA-related ICH survivors. Using Kaplan-Meier and Cox regression analyses, we investigated cortical superficial siderosis and ICH risk, adjusting for known confounders. Read More

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http://dx.doi.org/10.1177/1747493019830065DOI Listing
February 2019
2 Reads
3.833 Impact Factor

Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report.

BMC Neurol 2019 Feb 12;19(1):26. Epub 2019 Feb 12.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Background: Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presented with multiple intracerebral hemorrhages and a simultaneously occurring cerebral infarction with hemorrhagic transformation.

Case Presentation: A 63-year-old male with no history of trauma or prior neurological disease presented with a sudden onset of weakness in his right limbs, followed by an episode of focal seizure without impaired awareness. Read More

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http://dx.doi.org/10.1186/s12883-019-1248-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371517PMC
February 2019
6 Reads

Cerebral microbleeds: Beyond the macroscope.

Int J Stroke 2019 Feb 12:1747493019830594. Epub 2019 Feb 12.

1 Department of Medical Pharmacology, Univ Lille, Inserm U1171-Degenerative and Vascular Cognitive Disorders, CHU Lille, Lille, France.

While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling finding for physicians. These small dot-like lesions are thought to be old perivascular collections of hemosiderin deposits. They can be found in different neurological settings such as cerebrovascular or neurodegenerative diseases. Read More

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http://dx.doi.org/10.1177/1747493019830594DOI Listing
February 2019
8 Reads

Convexity Subarachnoid Hemorrhage Secondary to Adalidumab in a Patient with Ulcerative Colitis.

J Vasc Interv Neurol 2018 Nov;10(2):62-64

Department of Neurology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

The TNF-α antagonists are the drugs used for the treatment of ulcerative colitis (UC). Nontraumatic convexity subarachnoid hemorrhage is an infrequent nonaneurysmal subtype of subarachnoid bleeding caused mainly by reversible cerebral vasoconstriction syndrome (RCVS), cerebral amyloid angiopathy, and posterior reversible encephalopathy syndrome (PRES). We present a 26-year-old female patient with a diagnosis of UC taking Adalimumab. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350865PMC
November 2018
8 Reads

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain.

Front Aging Neurosci 2019 23;11. Epub 2019 Jan 23.

Mathematical Sciences, University of Southampton, Southampton, United Kingdom.

The human brain is the organ with the highest metabolic activity but it lacks a traditional lymphatic system responsible for clearing waste products. We have demonstrated that the basement membranes of cerebral capillaries and arteries represent the lymphatic pathways of the brain along which intramural periarterial drainage (IPAD) of soluble metabolites occurs. Failure of IPAD could explain the vascular deposition of the amyloid-beta protein as cerebral amyloid angiopathy (CAA), which is a key pathological feature of Alzheimer's disease. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357927PMC
January 2019
2 Reads

Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.

J Neurol Sci 2019 Apr 1;399:3-5. Epub 2019 Feb 1.

Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.01.051DOI Listing
April 2019
2 Reads

Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease.

Acta Neuropathol 2019 Feb 7. Epub 2019 Feb 7.

Faculté de pharmacie, Université Laval, Quebec, QC, Canada.

Several pieces of evidence suggest that blood-brain barrier (BBB) dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD), exemplified by the frequent occurrence of cerebral amyloid angiopathy (CAA) and the defective clearance of Aβ peptides. However, the specific role of brain microvascular cells in these anomalies remains elusive. In this study, we validated by Western, ELISA and immunofluorescence analyses a procedure to generate microvasculature-enriched fractions from frozen samples of human cerebral cortex. Read More

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http://dx.doi.org/10.1007/s00401-019-01967-4DOI Listing
February 2019
7 Reads

Multiple Approaches to Diffusion Magnetic Resonance Imaging in Hereditary Cerebral Amyloid Angiopathy Mutation Carriers.

J Am Heart Assoc 2019 Feb;8(3):e011288

1 Department of Radiology Leiden University Medical Center Leiden the Netherlands.

Background Cerebral amyloid angiopathy ( CAA ) is a major cause of lobar intracerebral hemorrhage in elderly adults; however, presymptomatic diagnosis of CAA is difficult. Hereditary cerebral hemorrhage with amyloidosis-Dutch type ( HCHWA -D) is a rare autosomal-dominant disease that leads to pathology similar to sporadic CAA . Presymptomatic HCHWA -D mutation carriers provide a unique opportunity to study CAA -related changes before any symptoms have occurred. Read More

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http://dx.doi.org/10.1161/JAHA.118.011288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405585PMC
February 2019
2 Reads

Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation.

J Neurol Sci 2019 Mar 3;398:107-116. Epub 2019 Jan 3.

Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Introduction: The novel D678H amyloid precursor protein (APP) gene mutation has been called the "Taiwan mutation". The study aims to identify amyloid deposition patterns and clinical features associated with this mutation.

Methods: we analyzed the clinical manifestations, brain neuroimages and F-AV-45 positron emission tomography (PET) findings in symptomatic patients and asymptomatic subjects with the autosomal-dominant Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.039DOI Listing
March 2019
1 Read

Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.

Neurology 2019 Feb 30;92(9):e933-e943. Epub 2019 Jan 30.

From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.

Objective: We sought to determine the underlying mechanism for altered white matter diffusion tensor imaging (DTI) measures at the histopathologic level in patients with cerebral amyloid angiopathy (CAA).

Methods: Formalin-fixed intact hemispheres from 9 CAA cases and 2 elderly controls were scanned at 3-tesla MRI, including a diffusion-weighted sequence. DTI measures (i. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404469PMC
February 2019
4 Reads

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy.

Acta Neuropathol Commun 2019 Jan 28;7(1):12. Epub 2019 Jan 28.

Department of Molecular Pathology, Faculty of Medical Sciences, University of Fukui, Fukui, 910-1193, Japan.

Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia. Biological molecules affecting the development of CAA have not been fully characterized. In this study, we performed proteome analysis of biopsied leptomeningeal and cortical vessels obtained from 6 CAA patients and 5 non-CAA patients who underwent surgery for large lobar hemorrhages. Read More

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http://dx.doi.org/10.1186/s40478-019-0662-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348632PMC
January 2019
1 Read

Comparison of methods for multivariate gene-based association tests for complex diseases using common variants.

Eur J Hum Genet 2019 May 25;27(5):811-823. Epub 2019 Jan 25.

Bioinformatics Graduate Program, Boston University, Boston, MA, USA.

Complex diseases are usually associated with multiple correlated phenotypes, and the analysis of composite scores or disease status may not fully capture the complexity (or multidimensionality). Joint analysis of multiple disease-related phenotypes in genetic tests could potentially increase power to detect association of a disease with common SNPs (or genes). Gene-based tests are designed to identify genes containing multiple risk variants that individually are weakly associated with a univariate trait. Read More

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http://dx.doi.org/10.1038/s41431-018-0327-8DOI Listing

Vasoprotective Functions of High-Density Lipoproteins Relevant to Alzheimer's Disease Are Partially Conserved in Apolipoprotein B-Depleted Plasma.

Int J Mol Sci 2019 Jan 22;20(3). Epub 2019 Jan 22.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

High-density lipoproteins (HDL) are known to have vasoprotective functions in peripheral arteries and many of these functions extend to brain-derived endothelial cells. Importantly, several novel brain-relevant HDL functions have been discovered using brain endothelial cells and in 3D bioengineered human arteries. The cerebrovascular benefits of HDL in healthy humans may partly explain epidemiological evidence suggesting a protective association of circulating HDL levels against Alzheimer's Disease (AD) risk. Read More

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http://dx.doi.org/10.3390/ijms20030462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387156PMC
January 2019

Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy.

Neurology 2019 Feb 23;92(8):e792-e801. Epub 2019 Jan 23.

From the Institute for Stroke and Dementia Research (F.A.W., C.O., C.C., R.M., M. Duering, M.J.K., M. Dichgans), University Hospital, LMU Munich; Klinik für Neurologie (C.O.), SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany; Stroke Unit-Neurology Unit and Neuroradiology Unit (M.Z., R.P.), Arcispedale Santa Maria Nuova, Azienda Unità Sanitaria Locale-IRCCS Reggio Emilia, Italy; Serviço de Neurologia (R.S., M.C.), Centro Hospitalar do Porto, Hospital de Santo António, Portugal; Hospital de la Santa Creu i Sant Pau (J.M.-F.), Biomedical Research Institute Sant Pau, IIB Sant Pau, Spain; Institut und Poliklinik für Neuroradiologie (J.L.), Universitätsklinikum Carl Gustav Carus, Dresden; Department of Neuroradiology (J.L.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich; Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans); and German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans), Germany.

Objective: To investigate the prognostic relevance of cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA).

Methods: A total of 302 patients fulfilling clinical and imaging criteria for probable or possible CAA were enrolled into a prospective, multicenter cohort study and followed for 12 months. cSS was assessed on T2*/susceptibility-weighted imaging MRI. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006956DOI Listing
February 2019
3 Reads

Microangiopathy underlying mixed-location intracerebral hemorrhages/microbleeds: A PiB-PET study.

Neurology 2019 Feb 23;92(8):e774-e781. Epub 2019 Jan 23.

From the Department of Neurology (H.H.T.), National Taiwan University Hospital Bei-Hu Branch, Taipei; Departments of Neurology (H.H.T., L.-K.T., S.-C.T., J.-S.J.), Medical Imaging (Y.-F.C., B.-C.L.), and Nuclear Medicine (R.-F.Y.), National Taiwan University Hospital, Taipei; Department of Neurology (M.P., P.F., M.E.G.), Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA; Graduate Institute of Clinical Medicine (H.H.T.) and Division of Cardiology (C.-Y.H.), Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei.

Objective: To test the hypothesis that patients with concomitant lobar and deep intracerebral hemorrhages/microbleeds (mixed ICH) have predominantly hypertensive small vessel disease (HTN-SVD) rather than cerebral amyloid angiopathy (CAA), using in vivo amyloid imaging.

Methods: Eighty Asian patients with primary ICH without dementia were included in this cross-sectional study. All patients underwent brain MRI and C-Pittsburgh compound B (PiB)-PET imaging. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396971PMC
February 2019
2 Reads
8.286 Impact Factor

Predictors of new remote cerebral microbleeds after IV thrombolysis for ischemic stroke.

Neurology 2019 Feb 23;92(7):e630-e638. Epub 2019 Jan 23.

From the Klinik und Hochschulambulanz für Neurologie (T.B.B., H.E., H.J.A., M.E., C.H.N., J.F.S.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (T.B.B., H.E., M.E., C.H.N., J.F.S.); Center for Stroke Research Berlin (T.B.B., K.V., G.T., J.B.F., H.J.A., M.E., C.H.N., J.F.S.), Charité-Universitätsmedizin Berlin, Germany; Department of Neurology (G.T.), Hôpital Sainte-Anne, Université Paris Descartes; INSERM U894 (G.T.), Paris, France; German Center for Cardiovascular Diseases (M.E., C.H.N., J.F.S.), partner site Berlin; German Center for Neurodegenerative Diseases (M.E.), partner site Berlin, Germany.

Objective: To assess the frequency, associated factors, and underlying vasculopathy of new remote cerebral microbleeds (CMB), as well as the risk of concomitant hemorrhagic complications related to new CMBs, after IV thrombolysis (IVT) in acute stroke patients.

Methods: We conducted an observational study using data from our local thrombolysis registry. We included consecutive stroke patients with MRI (3T)-based IVT and a follow-up MRI the next day between 2008 and 2017 (n = 396). Read More

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http://dx.doi.org/10.1212/WNL.0000000000006915DOI Listing
February 2019
1 Read

Width of sulcus and thickness of gyrus in patients with cerebral atherosclerosis: a new tool for the prevention of vascular cognitive impairment.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):684-691

. PhD in Pathology, Professor of Postgraduate Course Health Sciences, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba (MG), Brasil.

Background And Purpose: Cerebral atherosclerosis is the main cause of lesions that contribute to vascular cognitive impairment and vascular dementia, followed by arteriosclerosis of small vessels and cerebral amyloid angiopathy. The purpose of this study was to compare the post-mortem radiological alterations of autopsied adults with the macroscopic alterations in the posterior region of these brains in order to establish a relationship between the two forms of analysis and to discuss the relevance of the prevention of vascular cognitive impairment in patients with encephalic atherosclerosis.

Materials And Methods: Thirteen brains were analysed macroscopically to assess the degree of atherosclerosis of the basilar and the posterior cerebral arteries. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/1806-9282.64.08.684DOI Listing
August 2018
12 Reads

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study.

Alzheimers Res Ther 2019 Jan 22;11(1):11. Epub 2019 Jan 22.

Institute of Clinical Medicine, Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

Background: We developed multifactorial models for predicting incident dementia and brain pathology in the oldest old using the Vantaa 85+ cohort.

Methods: We included participants without dementia at baseline and at least 2 years of follow-up (N = 245) for dementia prediction or with autopsy data (N = 163) for pathology. A supervised machine learning method was used for model development, considering sociodemographic, cognitive, clinical, vascular, and lifestyle factors, as well as APOE genotype. Read More

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https://alzres.biomedcentral.com/articles/10.1186/s13195-018
Publisher Site
http://dx.doi.org/10.1186/s13195-018-0450-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343349PMC
January 2019
12 Reads