Radiology 2021 Mar 30:202423. Epub 2021 Mar 30.
From the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).
Background The third trimester of gestation is a crucial phase of rapid brain development, but little has been reported on the trajectories of cerebral blood flow (CBF) in preterm infants in this period. Purpose To quantify regional CBF in very preterm infants longitudinally across the ex utero third trimester and to determine its relationship with clinical factors associated with brain injury and premature birth. Materials and Methods In this prospective study, very preterm infants were enrolled for three longitudinal MRI scans, and 22 healthy full-term infants were enrolled for one term MRI scan between November 2016 and February 2019. Read More