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    Serial testing of the ICHD-3 beta diagnostic criteria for probable reversible cerebral vasoconstriction syndrome: A prospective validation study.
    Cephalalgia 2017 Jan 1:333102417744361. Epub 2017 Jan 1.
    1 Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Objectives To serially test the International Classification of Headache Disorders (ICHD) 3rd edition beta version criteria for 6.7.3. Read More

    Peripheral vagal nerve stimulation modulates the nociceptive withdrawal reflex in healthy subjects: A randomized, cross-over, sham-controlled study.
    Cephalalgia 2017 Jan 1:333102417742347. Epub 2017 Jan 1.
    1 Headache Science Centre, C. Mondino National Neurological Institute, Pavia, Italy.
    Introduction The mechanism of action of non-invasive vagal nerve stimulation in the treatment of migraine is elusive. We studied its effect in a human model of pain, the nociceptive withdrawal reflex. Methods We enrolled 10 healthy subjects who underwent active non-invasive vagal nerve stimulation and sham treatment in a randomized, cross-over, sham-controlled study. Read More

    Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L.
    Cephalalgia 2017 Jan 1:333102417742365. Epub 2017 Jan 1.
    1 Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
    Background Familial hemiplegic migraine type 3 is a monogenic subtype of migraine caused by missense mutations in the neuronal voltage-gated sodium channel gene SCN1A, with 10 different mutations reported so far. In two familial hemiplegic migraine type 3 families, partial cosegregation with a rare eye phenotype (elicited repetitive daily blindness) was previously reported. Methods Two novel familial hemiplegic migraine pedigrees were subjected to genetic analysis and detailed work-up of associated clinical features. Read More

    Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study.
    Cephalalgia 2017 Jan 1:333102417742375. Epub 2017 Jan 1.
    1 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients. Read More

    Salivary glutamate is elevated in individuals with chronic migraine.
    Cephalalgia 2017 Jan 1:333102417742366. Epub 2017 Jan 1.
    6 Department of Neurology, 65521 Kangnam Sacred Heart Hospital , Hallym University College of Medicine, Seoul, Republic of Korea.
    Background Glutamate has been implicated in migraine pathogenesis, and is elevated in the plasma, cerebrospinal fluid, and saliva in migraineurs. However, no comparison of glutamate levels among chronic migraine, episodic migraine and controls has been reported. The aim is to compare salivary glutamate levels of individuals with chronic migraine with those of individuals with episodic migraine and healthy controls. Read More

    CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data.
    Cephalalgia 2017 Jan 1:333102417741297. Epub 2017 Jan 1.
    Danish Headache Center, Dept. of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
    Introduction Migraine and cluster headache are challenging to manage, with no tailored preventive medications available. Targeting the calcitonin gene-related peptide (CGRP) pathway to treat these headaches may be the first focused therapeutic option to date, with the potential for promising efficacy. Methods We systematically searched PubMed and clinicaltrials. Read More

    Daily vision testing can expose the prodromal phase of migraine.
    Cephalalgia 2017 Jan 1:333102417741130. Epub 2017 Jan 1.
    3 University of Western Australia, School of Psychological Science, Perth, Australia.
    Background Several visual tasks have been proposed as indirect assays of the balance between cortical inhibition and excitation in migraine. This study aimed to determine whether daily measurement of performance on such tasks can reveal perceptual changes in the build up to migraine events. Methods Visual performance was measured daily at home in 16 non-headache controls and 18 individuals with migraine using a testing protocol on a portable tablet device. Read More

    Human mast cells release the migraine-inducing factor pituitary adenylate cyclase-activating polypeptide (PACAP).
    Cephalalgia 2017 Jan 1:333102417740563. Epub 2017 Jan 1.
    1 Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
    Background Many patients with migraines suffer from allergies and vice versa, suggesting a relationship between biological mechanisms of allergy and migraine. It was proposed many years ago that mast cells may be involved in the pathophysiology of migraines. We set out to investigate the relationship between mast cell activation and known neurogenic peptides related to migraine. Read More

    Phenotypic and treatment outcome data on SUNCT and SUNA, including a randomised placebo-controlled trial.
    Cephalalgia 2017 Jan 1:333102417739304. Epub 2017 Jan 1.
    2 University of California, San Francisco, San Francisco, San Francisco CA, USA.
    Background Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) are two rare headache syndromes classified broadly as Trigeminal Autonomic Cephalalgias (TACs). Methods Here, 65 SUNCT (37 males) and 37 SUNA (18 males) patients were studied to describe their clinical manifestations and responses to treatment. Results Pain was almost always unilateral and side-locked. Read More

    Influences on headache trigger beliefs and perceptions.
    Cephalalgia 2017 Jan 1:333102417739310. Epub 2017 Jan 1.
    1 Department of Anesthesia, Critical Care, and Pain Medicine, 2348 Massachusetts General Hospital , Boston, MA, USA.
    Background Previous headache trigger studies have primarily utilized checklists to measure beliefs about triggers. While this work has defined the diversity of beliefs across headache sufferers, the strength of association and the frequency at which these triggers are encountered remain unexplored. Objective To measure the strength of association, frequency of encounter, and influences on trigger beliefs and perceptions using a laboratory assessment task. Read More

    Gender aspects of CGRP in migraine.
    Cephalalgia 2017 Jan 1:333102417739584. Epub 2017 Jan 1.
    1 Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
    Background Migraine is two to three times more prevalent in women than in men, but the mechanisms involved in this gender disparity are still poorly understood. In this respect, calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology and, more recently, the functional interactions between ovarian steroid hormones, CGRP and the trigeminovascular system have been recognized and studied in more detail. Aims To provide an overview of CGRP studies that have addressed gender differences utilizing animal and human migraine preclinical research models to highlight how the female trigeminovascular system responds differently in the presence of varying ovarian steroid hormones. Read More

    Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks.
    Cephalalgia 2017 Jan 1:333102417738250. Epub 2017 Jan 1.
    1 Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Background Low frequency (LF) stimulation of the sphenopalatine ganglion (SPG) may increase parasympathetic outflow and provoke cluster headache (CH) attacks in CH patients implanted with an SPG neurostimulator. Methods In a double-blind randomized sham-controlled crossover study, 20 CH patients received LF or sham stimulation for 30 min on two separate days. We recorded headache characteristics, cephalic autonomic symptoms (CAS), plasma levels of parasympathetic markers such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal peptide (VIP), and mechanical detection and pain thresholds as a marker of sensory modulation. Read More

    Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks.
    Cephalalgia 2017 Jan 1:333102417738248. Epub 2017 Jan 1.
    Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Background Recently it has been suggested that low frequency stimulation of the sphenopalatine ganglion (SPG) may provoke cluster-like attacks in cluster headache (CH) patients. The question arises whether a robust activation of cranial autonomic symptoms is sufficient to trigger CH attacks. Methods Kinetic oscillation stimulation (KOS) of the nasal mucosa generates ipsilateral marked autonomic symptoms, among which lacrimation is quantitatively measurable. Read More

    Migraine with brainstem aura: Why not a cortical origin?
    Cephalalgia 2017 Jan 1:333102417738251. Epub 2017 Jan 1.
    1 Department of Neurology, Hospices Civils de Lyon, Lyon, France.
    Background Migraine with brainstem aura is defined as a migraine with aura including at least two of the following symptoms: dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia and/or decreased level of consciousness. Aim The aim of this study is to review data coming from clinical observations and functional mapping that support the role of the cerebral cortex in the initiation of brainstem aura symptoms. Results Vertigo can result from a vestibular cortex dysfunction, while tinnitus and hypacusis can originate within the auditory cortex. Read More

    The prevalence, course and clinical correlates of migraine in Parkinson's disease: A multicentre case-controlled study.
    Cephalalgia 2017 Jan 1:333102417739302. Epub 2017 Jan 1.
    1 Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
    Background Previous studies have reported a lower migraine prevalence in Parkinson's disease (PD) patients and improvements in migraine headaches after PD onset, but the clinical association of migraines with PD is unclear. Methods We analysed headache and migraine prevalence and clinical correlates in 436 PD patients (mean age, 69.3 ± 7. Read More

    Migraine and cognitive function: Baseline findings from the Brazilian Longitudinal Study of Adult Health: ELSA-Brasil.
    Cephalalgia 2017 Jan 1:333102417737784. Epub 2017 Jan 1.
    1 Center for Clinical and Epidemiological Research of the University of São Paulo, São Paulo, Brazil.
    Background The association between migraine and cognitive performance is unclear. We analyzed whether migraine is associated with cognitive performance among participants of the Brazilian Longitudinal Study of Adult Health, ELSA-Brasil. Methods Cross-sectional analysis, including participants with complete information about migraine and aura at baseline. Read More

    Complete detoxification is the most effective treatment of medication-overuse headache: A randomized controlled open-label trial.
    Cephalalgia 2017 Jan 1:333102417737779. Epub 2017 Jan 1.
    Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Denmark.
    Background There is lack of evidence on how to detoxify medication-overuse headache. Aim To compare the effect of complete stop of acute medication with restricted intake. Methods Medication-overuse headache patients were included in a prospective, outpatient study and randomized to two months' detoxification with either a) no analgesics or acute migraine-medication (program A), or b) acute medication restricted to two days/week (program B). Read More

    Supratentorial lesions contribute to trigeminal neuralgia in multiple sclerosis.
    Cephalalgia 2017 Jan 1:333102417737788. Epub 2017 Jan 1.
    1 Department of Neurology, 27168 University Hospital Erlangen , Friedrich-Alexander-University Erlangen-Nürnberg, Germany.
    Background It has been proposed that multiple sclerosis lesions afflicting the pontine trigeminal afferents contribute to trigeminal neuralgia in multiple sclerosis. So far, there are no imaging studies that have evaluated interactions between supratentorial lesions and trigeminal neuralgia in multiple sclerosis patients. Methods We conducted a retrospective study and sought multiple sclerosis patients with trigeminal neuralgia and controls in a local database. Read More

    Enhanced susceptibility to cortical spreading depression in two types of Na(+),K(+)-ATPase α2 subunit-deficient mice as a model of familial hemiplegic migraine 2.
    Cephalalgia 2017 Jan 1:333102417738249. Epub 2017 Jan 1.
    1 Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
    Background Patients with familial hemiplegic migraine type 2 (FHM2) have a mutated ATP1A2 gene (encoding Na(+),K(+)-ATPase α2 subunit) and show prolonged migraine aura. Cortical spreading depression (CSD), which involves mass depolarization of neurons and astrocytes that propagates slowly through the gray matter, is profoundly related to aura. Methods In two types of Atp1a2-defective heterozygous mice, Atp1a2(tm1Kwk) (C-KO) and Atp1a2(tm2Kwk) (N-KO), the sensitivity and responsiveness to CSD were examined under urethane anesthesia. Read More

    Treatment of acute migraine attacks in children with analgesics on the World Health Organization Essential Medicines List: A systematic review and GRADE evidence synthesis.
    Cephalalgia 2017 Jan 1:333102417736902. Epub 2017 Jan 1.
    2 Laboratory for Pain Research, University of Split School of Medicine, Split, Croatia.
    Background The World Health Organization Essential Medicines List (WHO EML) contains two analgesics for treatment of acute migraine attacks in children, ibuprofen and paracetamol. Methods The Embase, CDSR, CENTRAL, DARE and MEDLINE databases were searched up to 18 April 2017. We analyzed randomized controlled trials (RCTs) and systematic reviews (SRs) that investigate the efficacy and safety of ibuprofen or paracetamol for treatment of acute migraine attacks in children. Read More

    Role of adipocytokines in the pathophysiology of migraine. A cross-sectional study.
    Cephalalgia 2017 Jan 1:333102417731351. Epub 2017 Jan 1.
    1 Department of Neurology, Hospital Clinico Universitario, 16697 University of Santiago de Compostela , Santiago de Compostela, Spain.

    Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
    Cephalalgia 2017 Jan 1:333102417737778. Epub 2017 Jan 1.
    3 Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
    Background Nitric oxide (NO) has been heavily implicated in migraine. Nitroglycerin is a prototypic NO-donor, and triggers migraine in humans. However, nitroglycerin also induces oxidative/nitrosative stress and is a source of peroxynitrite - factors previously linked with migraine etiology. Read More

    Randomized, double-blind, placebo-controlled, parallel-group, multi-center study of the safety and efficacy of ADAM zolmitriptan for the acute treatment of migraine.
    Cephalalgia 2017 Jan 1:333102417737765. Epub 2017 Jan 1.
    6 Neurology Department, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
    Objective To determine the efficacy, tolerability, and safety of ascending doses of Adhesive Dermally-Applied Microarray (ADAM) zolmitriptan versus placebo for acute migraine treatment. Background ADAM is a novel patient-administered system for intracutaneous drug administration. In a phase 1 pharmacokinetic study, zolmitriptan administered using ADAM had much faster absorption than oral administration with higher exposure in the first two hours. Read More

    Recognizing the role of CGRP and CGRP receptors in migraine and its treatment.
    Cephalalgia 2017 Jan 1:333102417736900. Epub 2017 Jan 1.
    1 Department of Clinical Experimental Research, Glostrup Research Institute, Rigshospitalet, Glostrup, Denmark.
    Premise The brain and the sensory nervous system contain a rich supply of calcitonin gene-related peptide (CGRP) and CGRP receptor components. Clinical studies have demonstrated a correlation between CGRP release and acute migraine headache that led to the development of CGRP-specific drugs that either abort acute attacks of migraine (gepants) or are effective as prophylaxis (antibodies). However, there is still much discussion concerning the site of action of these drugs. Read More

    Transcranial static magnetic field stimulation (tSMS) of the visual cortex decreases experimental photophobia.
    Cephalalgia 2017 Jan 1:333102417736899. Epub 2017 Jan 1.
    1 FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain.
    Background Transcranial static magnetic field stimulation (tSMS) reduces cortical excitability in humans. Methods The objective of this study was to determine whether tSMS over the occipital cortex is effective in reducing experimental photophobia. In a sham-controlled double-blind crossover study, tSMS (or sham) was applied for 10 minutes with a cylindrical magnet on the occiput of 20 healthy subjects. Read More

    Explicit diagnostic criteria for transient ischemic attacks to differentiate it from migraine with aura.
    Cephalalgia 2017 Jan 1:333102417736901. Epub 2017 Jan 1.
    5 Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.
    Background The diagnosis of transient ischemic attacks is fraught with problems. The inter-observer agreement has repeatedly been shown to be low even in a neurological setting, and the specificity of the diagnosis is modest to low, reflected in a poor separation of transient ischemic attacks and mimics, particularly migraine with aura with its varied symptomatology. In other disease areas, explicit diagnostic criteria have improved sensitivity and specificity of diagnoses. Read More

    National awareness campaign to prevent medication-overuse headache in Denmark.
    Cephalalgia 2017 Jan 1:333102417736898. Epub 2017 Jan 1.
    1 Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Copenhagen, Denmark.
    Background Medication-overuse headache is prevalent, but in principle preventable. Objective To describe the Danish national awareness campaign for medication-overuse headache. Methods The Danish Headache Center, the Association of Danish Pharmacies, and headache patient organizations implemented a four-month medication-overuse headache awareness campaign in 2016. Read More

    Experimental evidence for weaker endogenous inhibition of trigeminal pain than extra-trigeminal pain in healthy individuals.
    Cephalalgia 2017 Jan 1:333102417735851. Epub 2017 Jan 1.
    2 Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
    Background and objectives The prevalence of pain syndromes that affect the territories innervated by the trigeminal nerve, such as headaches, is one of the highest and ranks second only to low back pain. A potential mechanism underlying this high prevalence may be a relatively weak endogenous pain modulation of trigeminal pain. Here, we sought to systematically compare endogenous pain modulation capabilities in the trigeminal region to those of extra-trigeminal regions in healthy subjects. Read More

    Microvascular decompression or neuromodulation in patients with SUNCT and trigeminal neurovascular conflict?
    Cephalalgia 2017 Jan 1:333102417735847. Epub 2017 Jan 1.
    1 Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
    Objectives To assess the effectiveness of neuromodulation and trigeminal microvascular decompression (MVD) in patients with medically-intractable short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT). Methods Two patients with medically refractory SUNCT underwent MVD following beneficial but incomplete response to neuromodulation (occipital nerve stimulation and deep brain stimulation). MRI confirmed neurovascular conflict with the ipsilateral trigeminal nerve in both patients. Read More

    Clinical, imaging and electroencephalographic characterization of three cases of HaNDL syndrome.
    Cephalalgia 2017 Jan 1:333102417735846. Epub 2017 Jan 1.
    Department of Neurology, 16517 Hospital Universitario de la Princesa , Instituto de Investigaciœn Sanitaria La Princesa, Madrid, Spain.
    Introduction The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) may mimic stroke when patients present with acute/subacute focal neurological deficits. It would be helpful to identify investigations that assist the neurologist in differentiating between HaNDL and stroke. Case reports We describe three cases that proved to be HaNDL, but were initially considered to be strokes. Read More

    CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior.
    Cephalalgia 2017 Jan 1:333102417735845. Epub 2017 Jan 1.
    1 Department of Neurology and Algology, Gazi University Medical School, Besevler, Ankara, Turkey.
    Background and objective The present study aimed to investigate the effects of selective calcitonin gene related peptide (CGRP) receptor antagonist (MK-8825) on cortical spreading depression (CSD) induced pain behavior and anxiety in freely-moving rats, and neuronal activation in the correlated anatomical regions. Methods CSD was induced while keeping all meningeal layers and BBB intact and MK-8825 was administered in two different doses. Regional cerebral blood flow (rCBF), arterial pressure and DC shift were recorded. Read More

    Exploring resting-state EEG complexity before migraine attacks.
    Cephalalgia 2017 Jan 1:333102417733953. Epub 2017 Jan 1.
    3 Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
    Objective Entropy-based approaches to understanding the temporal dynamics of complexity have revealed novel insights into various brain activities. Herein, electroencephalogram complexity before migraine attacks was examined using an inherent fuzzy entropy approach, allowing the development of an electroencephalogram-based classification model to recognize the difference between interictal and preictal phases. Methods Forty patients with migraine without aura and 40 age-matched normal control subjects were recruited, and the resting-state electroencephalogram signals of their prefrontal and occipital areas were prospectively collected. Read More

    Paediatric headache trajectories - a reappraisal after nine years.
    Cephalalgia 2017 Jan 1:333102417694803. Epub 2017 Jan 1.
    1 Department of Psychology, University of Göttingen, Göttingen, Germany.
    Background The long-term consequences of paediatric headache can involve functional disabilities and mental health problems in adulthood. Objective To analyse the predictive power of paediatric headache trajectory classes for headache and related outcomes in adulthood. Methods In a previous study, a population-based sample (N = 3227, 9-14 years of age at first assessment) was followed across four annual assessment points, and sex-specific headache trajectory classes were identified (girls: "no pain", "moderate pain", "increasing pain", "high pain"; boys: "no pain", "moderate pain"). Read More

    Altered brainstem anatomy in migraine.
    Cephalalgia 2017 Jan 1:333102417694884. Epub 2017 Jan 1.
    1 Department of Anatomy and Histology, University of Sydney, Sydney, NSW, Australia.
    Background The exact mechanisms responsible for migraine remain unknown, although it has been proposed that changes in brainstem anatomy and function, even between attacks, may contribute to the initiation and maintenance of headache during migraine attacks. The aim of this investigation is to use brainstem-specific analyses of anatomical and diffusion weighted images to determine if the trigeminal system displays altered structure in individuals with migraine. Methods Voxel-based morphometry of T1-weighted anatomical images (57 controls, 24 migraineurs) and diffusion tensor images (22 controls, 24 migraineurs) were used to assess brainstem anatomy in individuals with migraine compared with controls. Read More

    Gamma Knife radiosurgery for glossopharyngeal neuralgia: A study of 21 patients with long-term follow-up.
    Cephalalgia 2017 Jan 1:333102417698961. Epub 2017 Jan 1.
    1 Functional and Stereotactic Neurosurgery Unit, Centre Hospitalier Universitaire La Timone Assistance Publique-Hopitaux de Marseille, Université de la Méditerranée, INSERM U 751, Marseille, France.
    Objective Glossopharyngeal neuralgia (GPN) is a very rare condition, affecting the patient's quality of life. We report our experience in drug-resistant, idiopathic GPN, treated with Gamma Knife radiosurgery (GKRS), in terms of safety and efficiency, on a very long-term basis. Methods The study was opened, self-controlled, non-comparative and bicentric (Marseille and Lausanne University Hospitals). Read More

    Relationship between white matter hyperintensities and retinal nerve fiber layer, choroid, and ganglion cell layer thickness in migraine patients.
    Cephalalgia 2017 Jan 1:333102417694882. Epub 2017 Jan 1.
    1 Department of Neurology, Baskent University Faculty of Medicine, Ankara, Turkey.
    Aim To compare the relationship between white matter hyperintensities (WMH) on brain magnetic resonance imaging and retinal nerve fiber layer (RNFL), choroid, and ganglion cell layer (GCL) thicknesses in migraine patients and healthy subjects. We also assessed the role of cerebral hypoperfusion in the formation of these WMH lesions. Methods We enrolled 35 migraine patients without WMH, 37 migraine patients with WMH, and 37 healthy control subjects examined in the Neurology outpatient clinic of our tertiary center from May to December 2015. Read More

    Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.
    Cephalalgia 2017 Jan 1:333102417695105. Epub 2017 Jan 1.
    1 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background Susceptibility genes for migraine, despite it being a highly prevalent and disabling neurological disorder, have not been analyzed in Asians by genome-wide association study (GWAS). Methods We conducted a two-stage case-control GWAS to identify susceptibility genes for migraine without aura in Han Chinese residing in Taiwan. In the discovery stage, we genotyped 1005 clinic-based Taiwanese migraine patients and 1053 population-based sex-matched controls using Axiom Genome-Wide CHB Array. Read More

    Headache in cerebral venous sinus thrombosis revisited: Exploring the role of vascular congestion and cortical vein thrombosis.
    Cephalalgia 2017 Jan 1:333102417698707. Epub 2017 Jan 1.
    1 Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
    Background and purpose Headache constitutes the most common symptom of cerebral venous sinus thrombosis (CVST), but its pathophysiology is unclear. We sought to investigate the potential mechanism for headache genesis in patients with CVST based on its imaging correlates. Methods A subgroup of CVST patients having headache as the predominant symptom without significant parenchymal lesion were retrospectively analysed for imaging features of vascular congestion (VC), in addition to cortical venous (CVT) and dural sinus thrombosis (DST) on magnetic resonance imaging. Read More

    Coexistence of antiphospholipid antibodies and cephalalgia.
    Cephalalgia 2017 Jan 1:333102417694881. Epub 2017 Jan 1.
    3 Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
    Background The occurrence of antiphospholipid antibodies (aPLs) and headache comorbidity in the presence or absence of underlying autoimmune diseases remains unclear. Aim The aim of this review was to summarize the relationship between headache and aPLs based on evidences from cohort studies and case reports, in addition to examining the treatment strategies that resolved headache in aPLs-positive individuals. Methods A comprehensive literature search was conducted through PubMed, ISI Web of Science and Google Scholar. Read More

    Cilostazol induces C-fos expression in the trigeminal nucleus caudalis and behavioural changes suggestive of headache with the migraine-like feature photophobia in female rats.
    Cephalalgia 2017 Jan 1:333102417693833. Epub 2017 Jan 1.
    1 Danish Headache Center, Department of Neurology, Rigshospitalet, Glostrup, Denmark.
    Introduction Research in development of new migraine therapeutics is hindered by the lack of suitable, predictive animal models. Cilostazol provokes headache in healthy humans and migraineurs by increasing intracellular cAMP levels. We aimed to investigate whether cilostazol could provoke headache-like behaviours and c-fos expression in rats. Read More

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