5,001 results match your criteria Cephalalgia[Journal]


The prevalence of primary headache disorders in the adult population of Estonia.

Cephalalgia 2019 Feb 11:333102419829909. Epub 2019 Feb 11.

1 Neurology Clinic, Tartu University Hospital, Tartu, Estonia.

Objective: To estimate the one-year prevalence of primary headaches, most importantly migraine and tension type headache, but also other primary headaches, in Estonia.

Methods: A population-based random sample of 2162 subjects in Tartu City and Tartu County were interviewed by telephone or face to face using a previously validated questionnaire.

Results: Of the 2162 contacted participants, 1215 (56%) fully completed the study. Read More

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February 2019

Age related metabolic modifications in the migraine brain.

Cephalalgia 2019 Feb 11:333102419828984. Epub 2019 Feb 11.

5 Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Neurology, Brussels, Belgium.

Purpose: The aim of this study was to evaluate the possibility that migraine patients exhibit specific age-related metabolic changes in the brain, which occur regardless of disease duration or the frequency of attacks.

Methods: We analysed the relation between brain glucose (F-fluorodeoxyglucose) uptake and age in healthy volunteers (n = 20) and episodic migraine patients (n = 19). In the latter, we additionally compared the correlation between F-fluorodeoxyglucose uptake and disease duration and monthly migraine days. Read More

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February 2019

Predictors of allodynia in persons with migraine: Results from the Migraine in America Symptoms and Treatment (MAST) study.

Cephalalgia 2019 Feb 7:333102418825346. Epub 2019 Feb 7.

4 Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA.

Background: Cutaneous allodynia is a common clinical feature of migraine that has been associated with reduced efficacy of acute migraine treatments and an increased risk of disease progression.

Objective: Identify factors associated with allodynia in a sample of adults with migraine.

Methods: An online survey panel was used to identify adults with migraine who averaged at least 1 monthly headache day over the previous 3 months. Read More

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February 2019
4.891 Impact Factor

Complete withdrawal is the most effective approach to reduce disability in patients with medication-overuse headache: A randomized controlled open-label trial.

Cephalalgia 2019 Feb 7:333102419828994. Epub 2019 Feb 7.

Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.

Background: Medication-overuse headache leads to high disability and decreased quality of life, and the best approach for withdrawal has been debated.

Aim: To compare change in disability and quality of life between two withdrawal programs.

Methods: We randomized medication-overuse headache patients to program A (two months without acute analgesics or migraine medications) or program B (two months with acute medications restricted to two days/week) in a prospective, outpatient study. Read More

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February 2019
1 Read

Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study.

Cephalalgia 2019 Feb 2:333102419828989. Epub 2019 Feb 2.

2 Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Ullevål, Oslo, Norway.

Background: Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based setting.

Methods: We utilized a large, population-based cohort study from Norway, the HUNT Study. Read More

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February 2019

CGRP ligand and receptor monoclonal antibodies for migraine prevention: Evidence review and clinical implications.

Authors:
David W Dodick

Cephalalgia 2019 Jan 19:333102418821662. Epub 2019 Jan 19.

Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.

Background: Monoclonal antibodies that target calcitonin gene-related peptide or the canonical calcitonin gene-related peptide receptor have emerged as effective and well tolerated for the preventive treatment of migraine. These large molecules appear ideally suited for migraine prevention. They have an extended biological half-life, are administered either monthly or quarterly either by subcutaneous injection or intravenous infusion, require minimal or no dose-titration and have the potential for a rapid onset of effect compared to conventional oral preventive drugs. Read More

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January 2019
5 Reads

The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial.

Cephalalgia 2019 Jan 8:333102418820102. Epub 2019 Jan 8.

1 Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The current study was designed to assess the effect of supplementation with a 14-strain probiotic mixture on episodic and chronic migraine characteristics.

Methods: Forty episodic and 39 chronic migraine patients who completed this randomized double-blind controlled trial received two capsules of multispecies probiotic or placebo. The migraine severity was assessed by visual analog scale (VAS). Read More

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January 2019
7 Reads

Paroxysmal pressing headache: A new short-lasting headache.

Cephalalgia 2019 Jan 6:333102418821671. Epub 2019 Jan 6.

6 Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos, Madrid, Spain.

Introduction: In this report we describe a series of patients with a previously undescribed headache.

Methods: Over a 4-year period, we recruited 14 patients with a distinctive type of head pain of unknown cause that did not meet diagnostic criteria for other primary headaches.

Results: Nine women and five men with a mean age of 49. Read More

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January 2019
3 Reads

The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial.

Cephalalgia 2019 Jan 6:333102418821661. Epub 2019 Jan 6.

1 Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: The present study aimed to determine the effects of combined supplementation of Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders marker and migraine symptoms among migraine patients.

Methods: A total of 56 men and women, between 20-40 years of age with migraine headache, participated in this randomized, double-blind, placebo-controlled, parallel study. The subjects were randomly assigned to receive either 30 mg/day Coenzyme Q10 and 500 mg/day L-carnitine at the same time and/or placebo tablets for 8 weeks. Read More

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January 2019
3 Reads
4.891 Impact Factor

Greater occipital nerve block in migraine prophylaxis: Narrative review.

Cephalalgia 2019 Jan 6:333102418821669. Epub 2019 Jan 6.

5 Ministry of Health Ankara Research and Training Hospital, Algology Clinic, Ankara, Turkey.

Objectives: The importance and popularity of peripheral nerve block procedures have increased in the treatment of migraine. Greater occipital nerve (GON) block is a commonly used peripheral nerve block method, and there are numerous researches on its use in migraine treatment.

Materials And Methods: A search of PubMed for English-language randomized controlled trials (RCT) and open studies on greater occipital nerve block between 1995 and 2018 was performed using greater occipital nerve, headache, and migraine as keywords. Read More

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January 2019
2 Reads

PAC1 receptor mRNA and protein distribution in rat and human trigeminal and sphenopalatine ganglia, spinal trigeminal nucleus and in dura mater.

Cephalalgia 2018 Dec 24:333102418821621. Epub 2018 Dec 24.

10 Amgen Research, Department of Neuroscience, Cambridge, MA, USA.

Background: To further understand the role of pituitary adenylate cyclase-activating polypeptide 1 (PAC1) receptors in headache disorders, we mapped their expression in tissues of the trigemino-autonomic system by immunohistochemistry and in situ hybridization.

Methods: To optimize screening for monoclonal antibodies suitable for immunohistochemistry on formalin-fixed, paraffin-embedded tissues, we developed a new enzyme-linked immunosorbent assay using formalin-fixed, paraffin-embedded cells overexpressing human PAC1 receptors. 169G4. Read More

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December 2018
3 Reads

Cortical abnormalities in episodic migraine: A multi-center 3T MRI study.

Cephalalgia 2018 Dec 10:333102418795163. Epub 2018 Dec 10.

1 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.

Background: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies.

Objective: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. Read More

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December 2018
3 Reads

An unusual case of short-lasting unilateral neuralgiform headache attacks.

Cephalalgia 2018 Nov 27:333102418815652. Epub 2018 Nov 27.

1 Neurology Department, Hospital de Santo António, CHP - Centro Hospitalar do Porto, Porto, Portugal.

Background: Short-lasting unilateral neuralgiform headaches include those with conjunctival injection and tearing and with cranial autonomic symptoms. Most frequently reported as idiopathic, there is a growing number of symptomatic cases described.

Case Report: A 57-year old man presented a 16-year history of right hemifacial short-lasting pain attacks accompanied by ipsilateral autonomic symptoms and simultaneous malar contractions. Read More

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November 2018
3 Reads

Sleep in cluster headache revisited: Results from a controlled actigraphic study.

Cephalalgia 2018 Nov 23:333102418815506. Epub 2018 Nov 23.

1 Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Denmark.

Background And Aim: Cluster headache attacks exhibit a nocturnal predilection, but little is known of long-term sleep and circadian rhythm. The aim was to compare actigraphy measures, firstly in episodic cluster headache patients in bout and in remission and, secondly, to compare each disease phase with controls.

Methods: Episodic cluster headache patients (ICHD III-beta), from the Danish Headache Center and healthy, age- and sex-matched controls participated. Read More

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November 2018
12 Reads

Proposal for a Migraine Aura Complexity Score.

Cephalalgia 2018 Nov 20:333102418815487. Epub 2018 Nov 20.

1 Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Objectives: Currently, there is no scoring system for assessing the complexity of migraine aura. Our goal was to develop a Migraine Aura Complexity Score that synthesizes the quantity and quality of aura symptoms and to test its applicability in neuroimaging studies.

Methods: Patients with migraine aura were interviewed in order to obtain characteristics of migraine aura. Read More

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November 2018
9 Reads

Acute migraine therapy with external trigeminal neurostimulation (ACME): A randomized controlled trial.

Cephalalgia 2018 Nov 17:333102418811573. Epub 2018 Nov 17.

4 Headache Research Unit, University Department of Neurology CHR, Citadelle Hospital, Liege, Belgium.

Objective: To assess the safety and efficacy of external trigeminal nerve stimulation for acute pain relief during migraine attacks with or without aura via a sham-controlled trial.

Methods: This was a double-blind, randomized, sham-controlled study conducted across three headache centers in the United States. Adult patients who were experiencing an acute migraine attack with or without aura were recruited on site and randomly assigned 1:1 to receive either verum or sham external trigeminal nerve stimulation treatment (CEFALY Technology) for 1 hour. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348457PMC
November 2018
1 Read

Altered speech with migraine attacks: A prospective, longitudinal study of episodic migraine without aura.

Cephalalgia 2018 Nov 17:333102418815505. Epub 2018 Nov 17.

2 School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ, USA.

Background And Objective: Some individuals with migraine report the presence of speech changes during their migraine attacks. The goal of this study was to compare objective features of speech during the migraine pre-attack, the migraine attack, and during the interictal period.

Methods: This was a prospective, longitudinal, observational study of adults with episodic migraine and healthy non-migraine controls. Read More

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November 2018
2 Reads

Post traumatic headache (PTH) in a cohort of UK compensation claimants.

Cephalalgia 2018 Nov 8:333102418812091. Epub 2018 Nov 8.

2 University of Oxford, Oxford, UK.

Aim: To explore post traumatic headache characteristics and risk factors in compensation claimants by observational retrospective cohort analysis.

Case Results: Medicolegal reports on 116 consecutive compensation claimants aged 41.9 ± 15. Read More

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November 2018
16 Reads

Self-perceived attention deficit and hyperactivity symptom levels and risk of non-migraine and migraine headaches among university students: A cross-sectional study.

Cephalalgia 2018 Oct 22:333102418804155. Epub 2018 Oct 22.

1 Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: The aim was to evaluate the association of self-perceived levels of attention deficit and hyperactivity symptoms with non-migraine and migraine headaches among university students. We also evaluated their association with migraine aura.

Methods: Study subjects were all participants in the internet-based Students Health Research Enterprise. Read More

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October 2018
6 Reads

Diagnostic and classification tools for chronic headache disorders: A systematic review.

Cephalalgia 2018 Oct 18:333102418806864. Epub 2018 Oct 18.

3 Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background or aim Despite guidelines and the International Classification of Headache Disorders (ICHD-III beta) criteria, the diagnosis of common chronic headache disorders can be challenging for non-expert clinicians. The aim of the review was to identify headache classification tools that could be used by a non-expert clinician to classify common chronic disorders in primary care. Methods We conducted a systematic literature review of studies validating diagnostic and classification headache tools published between Jan 1988 and June 2016 from key databases: MEDLINE, ASSIA, Embase, Web of Knowledge and PsycINFO. Read More

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October 2018
12 Reads

Late Breaking Abstract Authors Index for MTIS 2018.

Authors:

Cephalalgia 2018 Sep;38(1_suppl):156-158

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September 2018
1 Read

Board Walk - October 2018.

Authors:

Cephalalgia 2018 Oct;38(11):1798-1799

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http://dx.doi.org/10.1177/0333102418791048DOI Listing
October 2018
1 Read

Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension.

Cephalalgia 2018 Dec 9;38(14):1998-2005. Epub 2018 Oct 9.

2 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei City, Taiwan.

Objectives: Several brain and spinal magnetic resonance imaging signs have been described in spontaneous intracranial hypotension. Their correlations are not fully studied. This study aimed to explore potential mechanisms underlying cerebral neuroimaging findings and to examine associations among spinal and brain magnetic resonance imaging signs. Read More

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http://journals.sagepub.com/doi/10.1177/0333102418804161
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December 2018
2 Reads

New daily persistent headache (NDPH) triggered by a single Valsalva event: A case series.

Authors:
Todd D Rozen

Cephalalgia 2018 Oct 9:333102418806869. Epub 2018 Oct 9.

Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.

Objective To describe a new subtype of new daily persistent headache that is triggered by a single Valsalva event. Methods A case series of patients was evaluated in an academic headache clinic over a 3-year time period. Results A total of seven patients (four female and three male) were diagnosed with this new subtype of new daily persistent headache. Read More

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October 2018
11 Reads

Cerebral autoregulation in migraine with aura: A case control study.

Cephalalgia 2018 Oct 8:333102418806861. Epub 2018 Oct 8.

1 Department of Neurology, University Hospital of Toulouse, Toulouse, France.

Background Migraine with aura is independently associated with increased risk of ischemic stroke, especially in younger subjects. This association might be related to an impairment of cerebral autoregulation, which normally maintains cerebral blood flow independent of arterial blood pressure variations. Methods Patients aged 30-55, fulfilling ICHD-3 beta criteria for migraine with aura, were prospectively enrolled and compared with gender- and age-matched healthy controls without a history of migraine. Read More

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October 2018
9 Reads

Increased use of illicit drugs in a Dutch cluster headache population.

Cephalalgia 2018 Oct 5:333102418804160. Epub 2018 Oct 5.

1 Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

Introduction Many patients with cluster headache report use of illicit drugs. We systematically assessed the use of illicit drugs and their effects in a well-defined Dutch cluster headache population. Methods In this cross-sectional explorative study, 756 people with cluster headache received a questionnaire on lifetime use and perceived effects of illicit drugs. Read More

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October 2018
6 Reads

Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache.

Cephalalgia 2018 Oct 4:333102418804157. Epub 2018 Oct 4.

1 Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

Background Loss of conditioned pain modulation/diffuse noxious inhibitory controls has been demonstrated in patients with migraine and medication overuse headache. We hypothesized that exposure to acute migraine medications may lead to dysregulation of central pain modulatory circuits that could be revealed by evaluating diffuse noxious inhibitory controls and that prior noxious stimulus is required for a loss of the diffuse noxious inhibitory control response in rats exposed to these medications. Methods Rats were "primed" by continuous infusion of morphine or one of two doses of sumatriptan. Read More

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October 2018
2 Reads

Benefit-risk assessment of erenumab and current migraine prophylactic treatments using the likelihood of being helped or harmed.

Cephalalgia 2018 Sep 19:333102418801579. Epub 2018 Sep 19.

1 Novartis Pharma AG, Basel, Switzerland.

Objective This study evaluated the benefit-risk profile of erenumab relative to other therapies approved for migraine prophylaxis and available in the majority of European countries. Methods Trials were identified via a published systematic literature review updated to December 2017 using MEDLINE. Erenumab's pivotal trials study reports were also included (NCT02066415, NCT02456740). Read More

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http://dx.doi.org/10.1177/0333102418801579DOI Listing
September 2018
2 Reads

Tracking patients with chronic occipital headache after occipital nerve decompression surgery: A case series.

Cephalalgia 2018 Sep 14:333102418801585. Epub 2018 Sep 14.

2 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background The therapeutic benefit of nerve decompression surgeries for chronic headache/migraine are controversial. Aim To provide clinical characteristics of headache type and treatment outcome of occipital nerve decompression surgery. Methods A retrospective review of clinical records. Read More

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http://dx.doi.org/10.1177/0333102418801585DOI Listing
September 2018
4 Reads

A prospective pilot study of the effect on catecholamines of mindfulness training vs pharmacological prophylaxis in patients with chronic migraine and medication overuse headache.

Cephalalgia 2018 Sep 13:333102418801584. Epub 2018 Sep 13.

5 Research and Innovation (R&I), Padova, Italy.

Aim To address whether, in patients with chronic migraine and medication overuse headache, mindfulness-based treatment is associated with changes in plasma levels of catecholamines and elusive amines that are similar to those observed in patients undergoing pharmacological prophylaxis. Methods In this non-randomized, clinic-based effectiveness study, patients aged 18-65, with a history of chronic migraine ≥ 10 years and overuse of triptans or non-steroidal anti-inflammatory drugs ≥ 5 years, were enrolled. Upon completion of a structured withdrawal program, patients received either pharmacological prophylaxis or six weekly sessions of mindfulness-based treatment and were followed for 12 months. Read More

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September 2018
3 Reads

Facial solitary morphea profunda presenting with painful trigeminal neuropathy: A case report.

Cephalalgia 2018 Sep 13:333102418801580. Epub 2018 Sep 13.

2 Department of Dermatology, Clínica Universidad de Navarra, Pamplona, Spain.

Background Localized facial scleroderma usually presents as frontal linear morphea or progressive hemifacial atrophy. Only isolated cases of trigeminal painful neuropathy have been described. Case report A 43-year-old woman developed an oval lesion on the right cheek. Read More

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http://dx.doi.org/10.1177/0333102418801580DOI Listing
September 2018
3 Reads

MTIS 2018 Abstracts.

Authors:

Cephalalgia 2018 Sep;38(1_suppl):1-115

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http://dx.doi.org/10.1177/0333102418789865DOI Listing
September 2018
2 Reads

MTIS 2018 Author index.

Authors:

Cephalalgia 2018 Sep;38(1_suppl):116-122

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http://dx.doi.org/10.1177/0333102418789866DOI Listing
September 2018
1 Read

Effect of the H-antihistamine clemastine on PACAP38 induced migraine.

Cephalalgia 2018 Aug 30:333102418798611. Epub 2018 Aug 30.

1 Danish Headache Centre and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Objective To investigate the effect of the H-antihistamine clemastine on the migraine-inducing abilities of pituitary adenylate cyclase activating peptide-38. Methods We conducted a double-blind, randomized, placebo controlled two-way cross-over study. Twenty migraine without aura patients were randomly allocated to receive bolus clemastine 2 mg (1 mg/ml) or bolus saline 2 ml intravenously over 2 min on two study days. Read More

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http://dx.doi.org/10.1177/0333102418798611DOI Listing
August 2018
2 Reads

Cost-effectiveness analysis of erenumab for the preventive treatment of episodic and chronic migraine: Results from the US societal and payer perspectives.

Cephalalgia 2018 09 24;38(10):1644-1657. Epub 2018 Aug 24.

1 Boston Health Economics, Inc., Waltham, MA, USA.

Objectives To assess the cost-effectiveness of erenumab 140 mg ("erenumab") for the prophylactic treatment of episodic migraine and chronic migraine. Study design A hybrid Monte Carlo patient simulation and Markov cohort model was constructed to compare erenumab to no preventive treatment or onabotulinumtoxinA among adult ( ≥ 18 years) patients with episodic migraine and chronic migraine who failed prior preventive therapy from the US societal and payer perspectives. Methods Patients entered the model one at a time and were assigned to a post-treatment monthly migraine day category based on baseline monthly migraine days and treatment effect. Read More

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http://dx.doi.org/10.1177/0333102418796842DOI Listing
September 2018
2 Reads

Rationale for electrical parameter determination in external trigeminal nerve stimulation (eTNS) for migraine: A narrative review.

Cephalalgia 2018 Aug 23:333102418796781. Epub 2018 Aug 23.

Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.

Background Migraine is a primary headache disorder involving dysregulation of central and peripheral pain pathways. Medical treatment is often limited by drug side effects, comorbidities and poor compliance. This makes neuromodulation an ideal option for migraine treatment. Read More

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http://dx.doi.org/10.1177/0333102418796781DOI Listing
August 2018
5 Reads

Treatment of acute migraine by a partial rebreathing device: A randomized controlled pilot study.

Cephalalgia 2018 Sep 22;38(10):1632-1643. Epub 2018 Aug 22.

1 Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Background Impaired brain oxygen delivery can trigger and exacerbate migraine attacks. Normoxic hypercapnia increases brain oxygen delivery markedly by vasodilation of the cerebral vasculature, and hypercapnia has been shown to abort migraine attacks. Stable normoxic hypercapnia can be induced by a compact partial rebreathing device. Read More

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http://dx.doi.org/10.1177/0333102418797285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158684PMC
September 2018
2 Reads

Thyrotropin levels and severity of symptoms in migraine patients of tertiary headache center.

Cephalalgia 2018 Aug 13:333102418794941. Epub 2018 Aug 13.

Department of Neurology, E. A. Vagner Perm State Medical University, Perm, Russia.

Background The role of thyroid regulation in migraine is poorly understood, and data is contradictory. Objective To study the possible association of clinical features of migraine with patients' thyroid function. Patients and methods One hundred and thirty migraine patients of a tertiary headache center took part in an open-label, cross-sectional comparative study. Read More

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http://dx.doi.org/10.1177/0333102418794941DOI Listing
August 2018
12 Reads

A case report of isolated orbital vasculitis mimicking retinal migraine: A potential cause of recurrent transient monocular blindness and ipsilateral headache.

Cephalalgia 2018 Aug 12:333102418794482. Epub 2018 Aug 12.

1 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background Retinal migraine is an important differential diagnosis of recurrent transient monocular blindness accompanied by headache when other etiologies are excluded. Here, we report a case of orbital vasculitis which initially mimicked retinal migraine. Case report A 47-year-old woman had recurrent episodes of fully reversible transient monocular blindness accompanied by ipsilateral headache for 15 months. Read More

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August 2018
6 Reads

Cyclic changes in sensations to painful stimuli in migraine patients.

Cephalalgia 2018 Aug 12:333102418793641. Epub 2018 Aug 12.

1 Institute of Physiology and Experimental Pathophysiology, University of Erlangen/Nürnberg, Germany.

Introduction Migraine is characterized by cycling phases (interictal, preictal, ictal and postictal) with differing symptoms, while in chronic tension type headache pain phases are fluctuating. The question we asked is whether these phases are associated with changes in parameters of somatosensation and axon-reflex erythema. Methods Patients with episodic migraine and chronic tension type headache were examined psychophysically in the interictal, preictal and ictal phase and healthy subjects on five different test days. Read More

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http://dx.doi.org/10.1177/0333102418793641DOI Listing
August 2018
3 Reads

Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension - a consecutive cohort study.

Cephalalgia 2019 Feb 12;39(2):306-315. Epub 2018 Aug 12.

1 Department of Neurosurgery, Inselspital, University of Bern, Bern, Switzerland.

Objective: Spontaneous intracranial hypotension is caused by spinal cerebrospinal fluid leakage. Patients with orthostatic headaches and cerebrospinal fluid leakage show a decrease in optic nerve sheath diameter upon movement from supine to upright position. We hypothesized that the decrease in optic nerve sheath diameter upon gravitational challenge would cease after closure of the leak. Read More

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http://journals.sagepub.com/doi/10.1177/0333102418793640
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http://dx.doi.org/10.1177/0333102418793640DOI Listing
February 2019
3 Reads

Neuronal injuries evidenced by transient cortical magnetic resonance enhancement in hemiplegic migraine: A case report.

Cephalalgia 2018 Aug 9:333102418794481. Epub 2018 Aug 9.

1 APHP, Pitié-Salpêtrière Hospital, Department of Neuroradiology, Paris, France.

Background Magnetic resonance imaging abnormalities in hemiplegic migraine have been described previously but were limited to a cortical thickening and biphasic alternation of hypoperfusion and hyperperfusion. Our report reveals possible blood-brain barrier disruption during migraine. Case We present the first demonstrated case of regressive diffuse hemispheric cortical enhancement in sporadic hemiplegic migraine, with histological correlation revealing neuronal lesions similar to ischemic lesions. Read More

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August 2018
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Pre- and postoperative headache in patients with meningioma.

Cephalalgia 2018 Aug 8:333102418793636. Epub 2018 Aug 8.

1 Institute of Physiology and Pathophysiology, University of Erlangen-Nürnberg, Erlangen, Germany.

Background Meningiomas are generally slowly growing intracranial tumors. They are often incidentally diagnosed, given that symptoms may be absent even in cases of an enormous tumor size. Headache is a frequent but not consistent symptom. Read More

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http://dx.doi.org/10.1177/0333102418793636DOI Listing
August 2018
2 Reads

Migraine is associated with high brain 5-HT levels as indexed by 5-HT receptor binding.

Cephalalgia 2018 Aug 8:333102418793642. Epub 2018 Aug 8.

1 Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Glostrup, Denmark.

Introduction Serotonin (5-HT) plays a role in migraine pathophysiology, but whether brain 5-HT is involved in the conversion from episodic to chronic migraine is unknown. Here, we investigated brain 5-HT levels, as indexed by 5-HT receptor binding, in chronic migraine patients and evaluated whether these were associated with migraine frequency. Methods Sixteen chronic migraine patients underwent a dynamic PET scan after injection of [C]SB207145, a specific 5-HT receptor radioligand. Read More

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http://dx.doi.org/10.1177/0333102418793642DOI Listing
August 2018
11 Reads

Correlation between nerve atrophy, brain grey matter volume and pain severity in patients with primary trigeminal neuralgia.

Cephalalgia 2018 Aug 7:333102418793643. Epub 2018 Aug 7.

1 Department of Medical Imaging, First affiliated hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background Recent neuroimaging studies have reported grey matter alterations in primary trigeminal neuralgia patients. However, few studies have focused on quantitative measurements of trigeminal nerves and the interaction between trigeminal nerve volume and brain morphology, particularly grey matter volume. In this study, we investigated the link between trigeminal nerves and grey matter volume changes in primary trigeminal neuralgia patients compared to healthy controls. Read More

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http://dx.doi.org/10.1177/0333102418793643DOI Listing
August 2018
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Migraine-related disability, impact, and health-related quality of life among patients with episodic migraine receiving preventive treatment with erenumab.

Cephalalgia 2018 09 7;38(10):1622-1631. Epub 2018 Aug 7.

7 Global Development, Amgen Inc., Thousand Oaks, CA, USA.

Background We evaluated the effect of erenumab, a fully human monoclonal antibody that inhibits the canonical calcitonin gene-related peptide receptor, on migraine-related disability, impact, and health-related quality of life among patients with episodic migraine. Methods Patients enrolled in a phase 3, 6-month, double-blind, placebo-controlled study of once-monthly erenumab 70 and 140 mg for migraine prevention (STRIVE) used an eDiary during the baseline and double-blind treatment phases to complete validated, specific questionnaires, including the modified (monthly) Migraine Disability Assessment Questionnaire; Headache Impact Test; and Migraine-Specific Quality of Life Questionnaire-role function-restrictive (MSQ-RFR), -role function-preventive (MSQ-RFP), and -emotional function (MSQ-EF). Results A total of 955 patients were randomized to receive erenumab 70 mg (n = 317), erenumab 140 mg (n = 319), or placebo (n = 319). Read More

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http://journals.sagepub.com/doi/10.1177/0333102418789072
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http://dx.doi.org/10.1177/0333102418789072DOI Listing
September 2018
25 Reads

Investigation of the characteristics of headache due to unruptured intracranial vertebral artery dissection.

Cephalalgia 2018 Aug 6:333102418791818. Epub 2018 Aug 6.

2 Department of Neurology, Cerebrovascular Research Institute, Eishokai Yoshida Hospital, Kobe, Japan.

Background and purpose It is sometimes difficult to diagnose intracranial vertebral artery dissection in patients with headache as the only symptom. Knowledge of the characteristics of the headache would facilitate the diagnosis. In this study, we aimed to clarify the characteristics of intracranial vertebral artery dissection-related headache using our original self-administered questionnaire. Read More

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http://dx.doi.org/10.1177/0333102418791818DOI Listing
August 2018
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Do pre-school episodic syndromes predict migraine in primary school children? A retrospective cohort study on health care data.

Cephalalgia 2018 Aug 4:333102418791820. Epub 2018 Aug 4.

3 Dr von Hauner Children's Hospital, Department of Paediatric Neurology and Developmental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

Objective To assess the relative risk, predictive value and population attributable risk fraction of pre-school episodic syndromes for later migraine in primary school age children. Methods This retrospective cohort study used health insurance data on 55,035 children born in 2006 with no diagnosis of migraine up to the age of 5 years. The relative risk, probability and population attributable risk fraction of migraine prompting a physician visit at the age of 6-10 years in children with episodic syndromes included in the International Classification of Headache Disorders (benign paroxysmal torticollis, benign paroxysmal vertigo, cyclic vomiting syndrome, recurrent abdominal symptoms and abdominal migraine) and those not included in the International Classification of Headache Disorders (pavor nocturnus, somnabulism and bruxism) diagnosed up to the age of 5 years were determined. Read More

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http://dx.doi.org/10.1177/0333102418791820DOI Listing
August 2018
17 Reads

Current understanding of thalamic structure and function in migraine.

Cephalalgia 2018 Aug 4:333102418791595. Epub 2018 Aug 4.

1 Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objective To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Read More

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http://journals.sagepub.com/doi/10.1177/0333102418791595
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August 2018
4 Reads

Board Walk - July 2018.

Authors:

Cephalalgia 2018 Jul;38(8):1509-1510

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http://dx.doi.org/10.1177/0333102418774435DOI Listing
July 2018
2 Reads