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    ARISE: A Phase 3 randomized trial of erenumab for episodic migraine.
    Cephalalgia 2018 Jan 1:333102418759786. Epub 2018 Jan 1.
    8 7129 Amgen Inc. , Thousand Oaks, CA, USA.
    Background Calcitonin gene-related peptide plays an important role in migraine pathophysiology. Erenumab, a human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor, is being evaluated for migraine prevention. Methods In this randomized, double-blind, placebo-controlled, phase 3 study, 577 adults with episodic migraine were randomized to placebo or 70 mg erenumab; 570 patients were included in efficacy analyses. Read More

    Evaluating the reporting of adverse events in controlled clinical trials conducted in 2010-2015 on migraine drug treatments.
    Cephalalgia 2018 Jan 1:333102418759785. Epub 2018 Jan 1.
    1 Danish Headache Center and Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark.
    Background In 2008, the International Headache Society published guidelines on the "evaluation and registration of adverse events in clinical drug trials on migraine". They listed seven recommendations for reporting adverse events in randomized controlled trials on migraine. The present study aimed to evaluate adherence to these recommendations, and based on the results, to recommend improvements. Read More

    Testing of diagnosis criteria of tension-type headache: A multicenter clinical study.
    Cephalalgia 2018 Jan 1:333102418759784. Epub 2018 Jan 1.
    1 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Objective Tension-type headache is *These authors contributed equally to this work. usually manifested as head pain without associated symptoms, and the validation of diagnostic criteria presented are lacking and highly required in the International Classification of Headache Disorders. The aim of the present study was to explore the diagnosis criteria of tension-type headache in a multicenter-based sample from Chongqing, China. Read More

    Neuroimaging utilization and findings in headache outpatients: Significance of red and yellow flags.
    Cephalalgia 2018 Jan 1:333102418758282. Epub 2018 Jan 1.
    2 Division of Primary Care Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
    Background Neuroimaging for headache commonly exceeds published guideline recommendations and may be overutilized. Methods We conducted a retrospective cross-sectional study of all outpatient community patients at Mayo Clinic Rochester who underwent a neuroimaging study for a headache indication in 2015. We assessed the neuroimaging utilization pattern, clinical application of red flags, and concordance with neuroimaging guidelines. Read More

    Prospective memory is dysfunctional in migraine without aura.
    Cephalalgia 2018 Jan 1:333102418758280. Epub 2018 Jan 1.
    2 Institute for Diagnosis and Care ''Hermitage Capodimonte'', Naples, Italy.
    Introduction Prospective memory is the ability to carry out a delayed intended action, so to maintain and retrieve future plans, goals and activities. Deficits of prospective memory negatively impact on patients and caregivers' everyday living and determine poor adherence to treatment. Since frontal regions are involved in both event- and time-based prospective memory tasks and are impaired in migraine without aura, defects of prospective memory might occur in migraine without aura patients; until now this issue has not been investigated. Read More

    The role of the brainstem in migraine: Potential brainstem effects of CGRP and CGRP receptor activation in animal models.
    Cephalalgia 2018 Jan 1:333102418756863. Epub 2018 Jan 1.
    Headache Group, Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, 4616 King's College London , London, UK.
    Background Migraine is a severe debilitating disorder of the brain that is ranked as the sixth most disabling disorder globally, with respect to disability adjusted life years, and there remains a significant unmet demand for an improved understanding of its underlying mechanisms. In conjunction with perturbed sensory processing, migraine sufferers often present with diverse neurological manifestations (premonitory symptoms) that highlight potential brainstem involvement. Thus, as the field moves away from the view of migraine as a consequence of purely vasodilation to a greater understanding of migraine as a complex brain disorder, it is critical to consider the underlying physiology and pharmacology of key neural networks likely involved. Read More

    Ictal headache: Insights from two cases.
    Cephalalgia 2018 Jan 1:333102418758281. Epub 2018 Jan 1.
    2 Dipartimento di Emergenza-Urgenza, ed Area Medica Generale e Specialistica, 18630 Azienda Ospedaliero-Universitaria di Parma , Parma, Italy.
    Background We report the first literature description of ictal epileptic headaches closely mimicking glossopharyngeal neuralgia and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. Case 1 A 37-year-old man complained of short-lasting, electric-shock like headache, confined to the pharynx. During the episodes, he could not speak because he felt "words blocked at the throat". Read More

    Migraine and the risk of incident hypertension among women.
    Cephalalgia 2018 Jan 1:333102418756865. Epub 2018 Jan 1.
    1 Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
    Background Few studies have examined whether migraine is associated with an increased risk of incident hypertension. Methods We performed a prospective cohort study among 29,040 women without hypertension at baseline. Women were classified as having active migraine with aura, active migraine without aura, a past history of migraine, or no history of migraine. Read More

    Cerebellar involvement in migraine.
    Cephalalgia 2018 Jan 1:333102417752120. Epub 2018 Jan 1.
    1 Dominick P Purpura Department of Neuroscience, 2006 Albert Einstein College of Medicine , New York, NY, USA.
    Background Although there is a great wealth of knowledge about the neurobiological processes underlying migraine and its accompanying symptoms, the mechanisms by which an attack starts remain elusive, and the disease remains undertreated. Although the vast majority of literature focuses on the involvement of the trigeminovascular systems and higher systems it innervates, such as thalamic and hypothalamic nuclei, several lines of evidence implicate the cerebellum in the pathophysiology of migraine. Aim In this review, we aim to summarize potential cerebellar involvement seen from different perspectives including the results from imaging studies, cerebellar connectivity to migraine-related brain structures, comorbidity with disorders implying cerebellar dysfunction, similarities in triggers precipitating both such disorders, and migraine and cerebellar expression of migraine-related genes and neuropeptides. Read More

    The effects of aerobic exercise for persons with migraine and co-existing tension-type headache and neck pain. A randomized, controlled, clinical trial.
    Cephalalgia 2018 Jan 1:333102417752119. Epub 2018 Jan 1.
    2 Danish Headache Centre, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
    Aim To evaluate aerobic exercise in migraine and co-existing tension-type headache and neck pain. Methods Consecutively recruited persons with migraine and co-existing tension-type headache and neck pain were randomized into an exercise group or control group. Aerobic exercise consisted of bike/cross-trainer/brisk walking for 45 minutes, three times/week. Read More

    Safety of galcanezumab in patients with episodic migraine: A randomized placebo-controlled dose-ranging Phase 2b study.
    Cephalalgia 2018 Jan 1:333102417747230. Epub 2018 Jan 1.
    3 Michigan Headache & Neurological Institute, Ann Arbor, MI, USA.
    Background Safety findings from a Phase 2b study of galcanezumab, a humanized monoclonal antibody against calcitonin gene-related peptide, for prevention of migraine (NCT02163993) are reported here. Methods Patients aged 18-65 years with episodic migraine were evaluated in this multicenter, double-blind, randomized study. After randomization, 410 patients were administered 5, 50, 120 or 300 mg of galcanezumab or placebo subcutaneously once every 4 weeks for 12 weeks, followed by a post-treatment off-drug period lasting 12 weeks. Read More

    Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine.
    Cephalalgia 2017 Jan 1:333102417748928. Epub 2017 Jan 1.
    2 Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
    Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic β-cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals. Read More

    Headache in the pediatric emergency department: A 5-year retrospective study.
    Cephalalgia 2017 Jan 1:333102417748907. Epub 2017 Jan 1.
    1 18691 A.O.U. Città della Salute e della Scienza di Torino , Regina Margherita Children's Hospital, Department of Pediatric Emergency, Pediatric Headache Centre, Turin, Italy.
    Aim To determine the red flags for serious organic causes of headache in children, to analyze if the management of headache in the Pediatric Emergency Department is appropriate, and whether the follow-up may limit repeated visits to the Emergency Department. Methods All the patients ≤ 18 years referred to our pediatric Emergency Department for non-traumatic headache over 5 years were retrospectively reviewed. The patients followed up by the Pediatric Headache Centre were also screened. Read More

    Diabetes is associated with decreased migraine risk: A nationwide cohort study.
    Cephalalgia 2017 Jan 1:333102417748573. Epub 2017 Jan 1.
    1 Department of Global Public Health and Primary Care, University of Bergen, Norway.
    Background Results from studies on diabetes and migraine risk are conflicting, which may be due to methodological limitations. Prospective studies with long follow-up could increase our understanding of the relationship between the two diseases. Method We performed a cohort study including the whole Norwegian population alive on 01. Read More

    Features of aura in paediatric migraine diagnosed using the ICHD 3 beta criteria.
    Cephalalgia 2017 Jan 1:333102417748571. Epub 2017 Jan 1.
    1 Headache Centre, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
    Background In children and adolescents, the prevalence rate of migraine with aura is 1.6%. Few studies concerning migraine with aura features in paediatric population have been reported. Read More

    Sarcoma family kinase activity is required for cortical spreading depression.
    Cephalalgia 2017 Jan 1:333102417748572. Epub 2017 Jan 1.
    1 Department of Biological Sciences, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, China.
    Objectives Sarcoma family kinase activity is associated with multiple diseases including ischemia and cancer; however, its role in the mechanism of migraine aura has been less well characterised. This study aims to investigate whether sarcoma family kinase is required for cortical spreading depression. Methods Cortical spreading depression was induced by topical application of Kto the cerebral cortex and was monitored using electrophysiology in rats, and intrinsic optical signal in mouse brain slices. Read More

    Pain worsening with physical activity during migraine attacks in women with overweight/obesity: A prospective evaluation of frequency, consistency, and correlates.
    Cephalalgia 2017 Jan 1:333102417747231. Epub 2017 Jan 1.
    1 Alpert Medical School of Brown University, Providence, RI, USA.
    Background Migraine is a neurological disease involving recurrent attacks of moderate-to-severe and disabling head pain. Worsening of pain with routine physical activity during attacks is a principal migraine symptom; however, the frequency, individual consistency, and correlates of this symptom are unknown. Given the potential of this symptom to undermine participation in daily physical activity, an effective migraine prevention strategy, further research is warranted. Read More

    Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management.
    Cephalalgia 2017 Jan 1:333102417748563. Epub 2017 Jan 1.
    1 Neurosciences Research Center (NSRC), 48432 Tabriz University of Medical Sciences , Tabriz, Iran.
    Background According to the neurovascular theory of migraine, activation of the trigeminovascular system contributes to the development of migraine. This study examined the effects of chronic intraperitoneal ghrelin (150 µg/kg) treatment on the development of chronic migraine induced by intermittent injection of nitroglycerin 10 mg/kg. Methods Baseline and post-drug (2 h following nitroglycerin injection) mechanical and thermal sensitivity were assessed by von Frey hair and tail immersion tests, respectively on days 1, 3, 5, 7, 9 and 11. Read More

    Modulation of salience network intranetwork resting state functional connectivity in women with chronic migraine.
    Cephalalgia 2017 Jan 1:333102417748570. Epub 2017 Jan 1.
    1 12322 University of South Carolina , Department of Neurology, Columbia, SC, USA.
    Objective To investigate the intranetwork resting state fMRI connectivity within the Salience Network of chronic migraine with and without medication overuse headache. Methods We compared 351 pairs of intranetwork connectivity in chronic migraine (n = 13) and chronic migraine with medication overuse headache (n = 16) compared to matched controls, and between each chronic migraine subgroup. Results Compared to controls, 17 pairs of intranetwork connections in chronic migraine and 27 pairs in chronic migraine with medication overuse headache were decreased. Read More

    Non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A randomized, double-blind, sham-controlled ACT2 study.
    Cephalalgia 2017 Jan 1:333102417744362. Epub 2017 Jan 1.
    2 Leiden University Medical Centre, Leiden, the Netherlands.
    Background Clinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device for acute treatment in patients with episodic or chronic CH (eCH, cCH). Methods After completing a 1-week run-in period, subjects were randomly assigned (1:1) to receive nVNS or sham therapy during a 2-week double-blind period. Read More

    Six-month clinical course and factors associated with non-improvement in migraine and non-migraine headaches.
    Cephalalgia 2017 Jan 1:333102417744360. Epub 2017 Jan 1.
    1 University of Sydney Faculty of Health Sciences, Sydney, New South Wales, Australia.
    Background Evidence on the medium-term clinical course of recurrent headaches is scarce. This study explored the six-month course and factors associated with non-improvement in migraine compared with tension-type headache and cervicogenic headache. Methods In this longitudinal cohort study, the six-month course of headaches was prospectively examined in participants (n = 37 with migraine; n = 42 with tension-type or cervicogenic headache). Read More

    Cluster headache and middle meningeal artery dural arteriovenous fistulas: A case report.
    Cephalalgia 2017 Jan 1:333102417747229. Epub 2017 Jan 1.
    1 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background Of the multiple etiologies identified for symptomatic cluster headache, vascular origin is common; however, there are no known reports of arteriovenous (AV) fistulas. Here we report a case with typical presentation of cluster headache, which might be associated with middle meningeal AV fistulas. Case report The subject is a 49-year-old man with a 7-year history of episodic left-side cluster headache, consistent with the criteria in the International Classification of Headache Disorders, 3rd edition, beta version (ICHD-3β). Read More

    Tolosa-Hunt Syndrome: Appraising the ICHD-3 beta diagnostic criteria.
    Cephalalgia 2017 Jan 1:333102417745271. Epub 2017 Jan 1.
    1 Department of Neurosurgery, 5925 Icahn School of Medicine at Mount Sinai , New York, NY, USA.
    Introduction The term Tolosa-Hunt Syndrome was first used more than half a century ago to describe painful ophthalmoplegia accompanied by cranial nerve palsies. In the decades since, its diagnostic criteria have evolved considerably. The beta version of the 3rd Edition of the International Classification of Headache Disorders narrows these criteria to require the demonstration of granulomatous inflammation on MRI or biopsy. Read More

    Serial testing of the ICHD-3 beta diagnostic criteria for probable reversible cerebral vasoconstriction syndrome: A prospective validation study.
    Cephalalgia 2017 Jan 1:333102417744361. Epub 2017 Jan 1.
    1 Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Objectives To serially test the International Classification of Headache Disorders (ICHD) 3rd edition beta version criteria for 6.7.3. Read More

    Peripheral vagal nerve stimulation modulates the nociceptive withdrawal reflex in healthy subjects: A randomized, cross-over, sham-controlled study.
    Cephalalgia 2017 Jan 1:333102417742347. Epub 2017 Jan 1.
    1 Headache Science Centre, C. Mondino National Neurological Institute, Pavia, Italy.
    Introduction The mechanism of action of non-invasive vagal nerve stimulation in the treatment of migraine is elusive. We studied its effect in a human model of pain, the nociceptive withdrawal reflex. Methods We enrolled 10 healthy subjects who underwent active non-invasive vagal nerve stimulation and sham treatment in a randomized, cross-over, sham-controlled study. Read More

    Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L.
    Cephalalgia 2017 Jan 1:333102417742365. Epub 2017 Jan 1.
    1 Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
    Background Familial hemiplegic migraine type 3 is a monogenic subtype of migraine caused by missense mutations in the neuronal voltage-gated sodium channel gene SCN1A, with 10 different mutations reported so far. In two familial hemiplegic migraine type 3 families, partial cosegregation with a rare eye phenotype (elicited repetitive daily blindness) was previously reported. Methods Two novel familial hemiplegic migraine pedigrees were subjected to genetic analysis and detailed work-up of associated clinical features. Read More

    Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study.
    Cephalalgia 2017 Jan 1:333102417742375. Epub 2017 Jan 1.
    1 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
    Background Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients. Read More

    Salivary glutamate is elevated in individuals with chronic migraine.
    Cephalalgia 2017 Jan 1:333102417742366. Epub 2017 Jan 1.
    6 Department of Neurology, 65521 Kangnam Sacred Heart Hospital , Hallym University College of Medicine, Seoul, Republic of Korea.
    Background Glutamate has been implicated in migraine pathogenesis, and is elevated in the plasma, cerebrospinal fluid, and saliva in migraineurs. However, no comparison of glutamate levels among chronic migraine, episodic migraine and controls has been reported. The aim is to compare salivary glutamate levels of individuals with chronic migraine with those of individuals with episodic migraine and healthy controls. Read More

    CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data.
    Cephalalgia 2017 Jan 1:333102417741297. Epub 2017 Jan 1.
    Danish Headache Center, Dept. of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
    Introduction Migraine and cluster headache are challenging to manage, with no tailored preventive medications available. Targeting the calcitonin gene-related peptide (CGRP) pathway to treat these headaches may be the first focused therapeutic option to date, with the potential for promising efficacy. Methods We systematically searched PubMed and clinicaltrials. Read More

    Daily vision testing can expose the prodromal phase of migraine.
    Cephalalgia 2017 Jan 1:333102417741130. Epub 2017 Jan 1.
    3 University of Western Australia, School of Psychological Science, Perth, Australia.
    Background Several visual tasks have been proposed as indirect assays of the balance between cortical inhibition and excitation in migraine. This study aimed to determine whether daily measurement of performance on such tasks can reveal perceptual changes in the build up to migraine events. Methods Visual performance was measured daily at home in 16 non-headache controls and 18 individuals with migraine using a testing protocol on a portable tablet device. Read More

    Human mast cells release the migraine-inducing factor pituitary adenylate cyclase-activating polypeptide (PACAP).
    Cephalalgia 2017 Jan 1:333102417740563. Epub 2017 Jan 1.
    1 Immunology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
    Background Many patients with migraines suffer from allergies and vice versa, suggesting a relationship between biological mechanisms of allergy and migraine. It was proposed many years ago that mast cells may be involved in the pathophysiology of migraines. We set out to investigate the relationship between mast cell activation and known neurogenic peptides related to migraine. Read More

    Phenotypic and treatment outcome data on SUNCT and SUNA, including a randomised placebo-controlled trial.
    Cephalalgia 2017 Jan 1:333102417739304. Epub 2017 Jan 1.
    2 University of California, San Francisco, San Francisco, San Francisco CA, USA.
    Background Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) are two rare headache syndromes classified broadly as Trigeminal Autonomic Cephalalgias (TACs). Methods Here, 65 SUNCT (37 males) and 37 SUNA (18 males) patients were studied to describe their clinical manifestations and responses to treatment. Results Pain was almost always unilateral and side-locked. Read More

    Influences on headache trigger beliefs and perceptions.
    Cephalalgia 2017 Jan 1:333102417739310. Epub 2017 Jan 1.
    1 Department of Anesthesia, Critical Care, and Pain Medicine, 2348 Massachusetts General Hospital , Boston, MA, USA.
    Background Previous headache trigger studies have primarily utilized checklists to measure beliefs about triggers. While this work has defined the diversity of beliefs across headache sufferers, the strength of association and the frequency at which these triggers are encountered remain unexplored. Objective To measure the strength of association, frequency of encounter, and influences on trigger beliefs and perceptions using a laboratory assessment task. Read More

    Gender aspects of CGRP in migraine.
    Cephalalgia 2017 Jan 1:333102417739584. Epub 2017 Jan 1.
    1 Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
    Background Migraine is two to three times more prevalent in women than in men, but the mechanisms involved in this gender disparity are still poorly understood. In this respect, calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology and, more recently, the functional interactions between ovarian steroid hormones, CGRP and the trigeminovascular system have been recognized and studied in more detail. Aims To provide an overview of CGRP studies that have addressed gender differences utilizing animal and human migraine preclinical research models to highlight how the female trigeminovascular system responds differently in the presence of varying ovarian steroid hormones. Read More

    Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks.
    Cephalalgia 2017 Jan 1:333102417738250. Epub 2017 Jan 1.
    1 Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Background Low frequency (LF) stimulation of the sphenopalatine ganglion (SPG) may increase parasympathetic outflow and provoke cluster headache (CH) attacks in CH patients implanted with an SPG neurostimulator. Methods In a double-blind randomized sham-controlled crossover study, 20 CH patients received LF or sham stimulation for 30 min on two separate days. We recorded headache characteristics, cephalic autonomic symptoms (CAS), plasma levels of parasympathetic markers such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal peptide (VIP), and mechanical detection and pain thresholds as a marker of sensory modulation. Read More

    Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks.
    Cephalalgia 2017 Jan 1:333102417738248. Epub 2017 Jan 1.
    Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Background Recently it has been suggested that low frequency stimulation of the sphenopalatine ganglion (SPG) may provoke cluster-like attacks in cluster headache (CH) patients. The question arises whether a robust activation of cranial autonomic symptoms is sufficient to trigger CH attacks. Methods Kinetic oscillation stimulation (KOS) of the nasal mucosa generates ipsilateral marked autonomic symptoms, among which lacrimation is quantitatively measurable. Read More

    Migraine with brainstem aura: Why not a cortical origin?
    Cephalalgia 2017 Jan 1:333102417738251. Epub 2017 Jan 1.
    1 Department of Neurology, Hospices Civils de Lyon, Lyon, France.
    Background Migraine with brainstem aura is defined as a migraine with aura including at least two of the following symptoms: dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia and/or decreased level of consciousness. Aim The aim of this study is to review data coming from clinical observations and functional mapping that support the role of the cerebral cortex in the initiation of brainstem aura symptoms. Results Vertigo can result from a vestibular cortex dysfunction, while tinnitus and hypacusis can originate within the auditory cortex. Read More

    The prevalence, course and clinical correlates of migraine in Parkinson's disease: A multicentre case-controlled study.
    Cephalalgia 2017 Jan 1:333102417739302. Epub 2017 Jan 1.
    1 Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
    Background Previous studies have reported a lower migraine prevalence in Parkinson's disease (PD) patients and improvements in migraine headaches after PD onset, but the clinical association of migraines with PD is unclear. Methods We analysed headache and migraine prevalence and clinical correlates in 436 PD patients (mean age, 69.3 ± 7. Read More

    Migraine and cognitive function: Baseline findings from the Brazilian Longitudinal Study of Adult Health: ELSA-Brasil.
    Cephalalgia 2017 Jan 1:333102417737784. Epub 2017 Jan 1.
    1 Center for Clinical and Epidemiological Research of the University of São Paulo, São Paulo, Brazil.
    Background The association between migraine and cognitive performance is unclear. We analyzed whether migraine is associated with cognitive performance among participants of the Brazilian Longitudinal Study of Adult Health, ELSA-Brasil. Methods Cross-sectional analysis, including participants with complete information about migraine and aura at baseline. Read More

    Complete detoxification is the most effective treatment of medication-overuse headache: A randomized controlled open-label trial.
    Cephalalgia 2018 Feb 19;38(2):225-236. Epub 2017 Oct 19.
    Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Denmark.
    Background There is lack of evidence on how to detoxify medication-overuse headache. Aim To compare the effect of complete stop of acute medication with restricted intake. Methods Medication-overuse headache patients were included in a prospective, outpatient study and randomized to two months' detoxification with either a) no analgesics or acute migraine-medication (program A), or b) acute medication restricted to two days/week (program B). Read More

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