4,939 results match your criteria Cephalalgia[Journal]
Cephalalgia 2018 Jan 1:333102418784751. Epub 2018 Jan 1.
2 Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
Aim To compare the prevalence of unhealthy lifestyle factors and comorbid disorders in cluster headache patients with headache-free controls, in order to discuss pathophysiology and possible consequences. Methods Cluster headache patients from the Danish cluster headache survey aged 18-65 years, diagnosed according to ICHD-II, were compared to sex- and age-matched headache-free controls. Participants completed questionnaires and structured interviews. Read More
Cephalalgia 2018 Jan 1:333102418771350. Epub 2018 Jan 1.
3 Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Background The exact mechanisms underlying the onset of a migraine attack are not completely understood. It is, however, now well accepted that the onset of the excruciating throbbing headache of migraine is mediated by the activation and increased mechanosensitivity (i.e. Read More
Cephalalgia 2018 Jan 1:333102418784747. Epub 2018 Jan 1.
5 G. B. Bietti Foundation IRCCS, Research Unit of Neurophysiology of Vision and Neurophthalmology, Rome, Italy.
Objective To study the effects of trains of repetitive transcranial magnetic stimulation (rTMS) over the motor cortex in patients with chronic migraine (CM) with or without medication overuse (MOH). Subjects and methods Thirty-two patients (CM [n = 16]; MOH [n = 16]) and 16 healthy volunteers (HVs) underwent rTMS recording. Ten trains of 10 stimuli each (120% resting motor threshold) were applied over the left motor cortex at 1 Hz or 5 Hz in random order. Read More
Cephalalgia 2018 Jan 1:333102418784689. Epub 2018 Jan 1.
4 Migraine and Headache Clinic Königstein, Königstein im Taunus, Germany.
Background On-demand stimulation of the sphenopalatine ganglion (SPG) by means of an implantable neurostimulation system has been shown to be a safe and effective therapy for treatment-refractory cluster headache patients. Our objective was to estimate changes in cluster headache medication cost observed in SPG-treated chronic patients. Methods Detailed patient-level data of 71 chronic patients treated with the Pulsante® SPG Microstimulator System were available from the Pathway R-1 Registry through 12 months' follow-up. Read More
Cephalalgia 2018 Jan 1:333102418782192. Epub 2018 Jan 1.
1 Metabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Background Headache is disabling and prevalent in idiopathic intracranial hypertension. Therapeutic lumbar punctures may be considered to manage headache. This study evaluated the acute effect of lumbar punctures on headache severity. Read More
Cephalalgia 2018 Jan 1:333102418783295. Epub 2018 Jan 1.
1 Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
Background Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. Methods We investigated in 2829 migraine patients (14% males) whether 'migraine frequency' (measured as the number of migraine days per month) was related to 'genetic load' (measured as the number of parents affected with migraine) using a validated web-based questionnaire. Read More
Cephalalgia 2018 Jan 1:333102418780426. Epub 2018 Jan 1.
1 Pain Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Introduction Persistent idiopathic facial pain is a refractory and disabling condition of unknown mechanism and etiology. It has been suggested that persistent idiopathic facial pain patients have not only peripheral generators of pain, but also central nervous system changes that would contribute to the persistence of symptoms. We hypothesized that persistent idiopathic facial pain would have changes in brain cortical excitability as measured by transcranial magnetic stimulation compared to healthy controls. Read More
Cephalalgia 2018 Jan 1:333102418776455. Epub 2018 Jan 1.
1 Metabolic Neurology, Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK.
Background The management of idiopathic intracranial hypertension focuses on reducing intracranial pressure to preserve vision and reduce headaches. There is sparse evidence to support the use of some of the drugs commonly used to manage idiopathic intracranial hypertension, therefore we propose to evaluate the efficacy of these drugs at lowering intracranial pressure in healthy rats. Methods We measured intracranial pressure in female rats before and after subcutaneous administration of acetazolamide, topiramate, furosemide, amiloride and octreotide at clinical doses (equivalent to a single human dose) and high doses (equivalent to a human daily dose). Read More
Cephalalgia 2018 Jan 1:333102418783294. Epub 2018 Jan 1.
1 Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Denmark.
Introduction There is a lack of high-quality prospective, systematic studies using independent assessors of outcome of microvascular decompression as treatment for trigeminal neuralgia. Methods Clinical characteristics and outcome data were recorded prospectively from consecutive classical trigeminal neuralgia patients, using standardized interviews. Degree of neurovascular contact was evaluated by a 3. Read More
Cephalalgia 2018 Jan 1:333102418781644. Epub 2018 Jan 1.
6 Danish Headache Center, University of Copenhagen, Rigshopitalet, Glostrup, Denmark.
Background Headache disorders comprise the three most prevalent medical disorders globally and contribute almost 20% to the total burden of neurologic illness. Although the experience of a recurrent headache disorder tends to be highly individualized, patient preferences tend to be a low priority in guidelines for the management of patients with headache. Methods In September 2017, the first Global Patient Advocacy Summit was convened, bringing together patients, patient advocates, patient advocacy organizations, healthcare professionals, pharmaceutical manufacturers, scientists, and regulatory agencies to advance issues of importance to patients affected by headache worldwide. Read More
Cephalalgia 2018 Jan 1:333102418781814. Epub 2018 Jan 1.
Division of Pediatric Emergency Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Background Clinicians appear to obtain emergent neuroimaging for children with headaches based on the presence of red flag findings. However, little data exists regarding the prevalence of these findings in emergency department populations, and whether the identification of red flag findings is associated with potentially unnecessary emergency department neuroimaging. Objectives We aimed to determine the prevalence of red flag findings and their association with neuroimaging in otherwise healthy children presenting with headaches to the emergency department. Read More
Cephalalgia 2018 Jan 1:333102418781789. Epub 2018 Jan 1.
2 Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Background Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory central nervous system disorder, typically presenting with subacute symptoms referable to brainstem and cerebellar pathology. This is the first report of CLIPPERS presenting with a painful trigeminal neuropathy. Case report We report an unusual case of CLIPPERS presenting with facial pain and sensory symptoms, in the absence of other brainstem or cerebellar signs. Read More
Cephalalgia 2018 Jan 1:333102418781795. Epub 2018 Jan 1.
1 Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Background Mindfulness-based stress reduction/cognitive therapy are frequently used for pain-related conditions, but their effects on headache remain uncertain. This review aimed to assess the efficacy and safety of mindfulness-based stress reduction/cognitive therapy in reducing the symptoms of chronic headache. Data sources and study selection MEDLINE/PubMed, Scopus, CENTRAL, and PsychINFO were searched to 16 June 2017. Read More
Cephalalgia 2018 Jan 1:333102418779548. Epub 2018 Jan 1.
1 School of Brain and Behavioral Sciences, University of Texas at Dallas, TX, USA.
Background Pain is the most debilitating symptom of migraine. The cause of migraine pain likely requires activation of meningeal nociceptors. Mast cell degranulation, with subsequent meningeal nociceptor activation, has been implicated in migraine pathophysiology. Read More
Cephalalgia 2018 Jan 1:333102418780632. Epub 2018 Jan 1.
1 Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Background The relationship between subcortical nuclei and headache is unclear. Most previous studies were conducted in small clinical migraine samples. In the present population-based MRI study, we hypothesized that headache sufferers exhibit reduced volume and deformation of the nucleus accumbens compared to non-sufferers. Read More
Cephalalgia 2018 Jan 1:333102418779557. Epub 2018 Jan 1.
1 School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA.
Background Migraine is characterized by a collection of neurological symptoms in the absence of injury or damage. However, several common preclinical migraine models require significant damage to the skull to stimulate the dura mater, the likely source of afferent signaling leading to head pain. The goal of this study was to determine whether dural stimulation can be performed in mice using an injection that does not cause injury or damage. Read More
Cephalalgia 2018 Jan 1:333102418779543. Epub 2018 Jan 1.
1 Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA.
Introduction Galcanezumab is a humanized monoclonal antibody binding calcitonin gene-related peptide, used for migraine prevention. Methods A global, double-blind, 6-month study of patients with episodic migraine was undertaken with 915 intent-to-treat patients randomized to monthly galcanezumab 120 mg (n = 231) or 240 mg (n = 223) or placebo (n = 461) subcutaneous injections. Primary endpoint was overall mean change from baseline in monthly migraine headache days. Read More
Cephalalgia 2018 Jan 1:333102418780485. Epub 2018 Jan 1.
1 Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
Cephalalgia 2018 Jan 1:333102418779542. Epub 2018 Jan 1.
2 Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Cephalalgia 2018 Jan 1:333102418776017. Epub 2018 Jan 1.
5 Neuroscience Early Development, Amgen, Thousand Oaks, CA, USA.
Objectives The aim of this study was to assess the effects of concomitant administration of erenumab and sumatriptan on resting blood pressure, pharmacokinetics, safety, and tolerability in healthy subjects. Methods In this phase 1, parallel-group, one-way crossover, double-blind, placebo-controlled study, healthy adult subjects were randomized (1:2) to receive either intravenous placebo and subcutaneous sumatriptan 12 mg (i.e. Read More
Cephalalgia 2018 Jan 1:333102418777507. Epub 2018 Jan 1.
1 Department of Psychiatry, University of Illinois at Chicago, Department of Psychiatry, Chicago, IL, USA.
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Read More
Cephalalgia 2018 Jan 1:333102418777509. Epub 2018 Jan 1.
1 Headache & Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Objective To evaluate the prevalence and characteristics of headache and its relationship with comorbidities and lifestyle in a teenage population. Methods This is a cross-sectional study. Data was collected from students aged 12-18 years from six different schools in Catalonia, Spain. Read More
Cephalalgia 2018 Jan 1:333102418776016. Epub 2018 Jan 1.
1 Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background Previous studies have demonstrated the analgesic effects of ginger in different conditions, but evidence about its efficacy in migraine treatment is scarce. Objective This study aimed to evaluate the potential of ginger to improve acute migraine as an add-on strategy to standard treatment. Methods A double-blind placebo-controlled randomized clinical trial in the emergency room of a general hospital was conducted. Read More
Cephalalgia 2018 Jan 1:333102418768824. Epub 2018 Jan 1.
1 Headache Centre, Careggi University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.
Background Rare primary headaches are mainly included in Chapters 3, Trigeminal autonomic cephalalgias, and 4, Other primary headache disorders, Part One of the International Classification of Headache Disorders 3rd edition. Epidemiological data are scarce, mostly emerging from case series or small studies, with the exception of cluster headache. In order to overcome the knowledge gap about rare primary headaches, the RegistRare Network was launched in 2017 to promote research in the field. Read More
Cephalalgia 2018 Jan 1:333102418776469. Epub 2018 Jan 1.
Department of Developmental Neurology, Medical University of Gdańsk, Gdańsk, Poland.
Cephalalgia 2018 Jan 1:333102418776018. Epub 2018 Jan 1.
Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's Medical Center of Israel, Petach Tikva; affiliated; and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background Allodynia is prevalent in adults with migraine and has been associated with long disease duration and severe course. Studies of the pediatric population are sparse. The aim of this study was to evaluate the rate of cephalic cutaneous allodynia in children and adolescents within the first 6 months of migraine onset and to identify associated clinical and migraine-related parameters. Read More
Cephalalgia 2018 Jan 1:333102418772585. Epub 2018 Jan 1.
1 Mayo Clinic, Scottsdale, AZ, USA.
Background In phase 2 and 3 studies, fremanezumab, a monoclonal CGRP antibody, was an effective preventive treatment for high-frequency episodic migraine (HFEM) and chronic migraine (CM). Objective Post-hoc analyses evaluated population-wise 50%, 75% and 100% responder rates, and the extent to which individual responders sustained a 50%, 75% and 100% reduction in migraine days, moderate-to-severe (M/S) headache days and days of acute medication use during all three treatment months of the fremanezumab phase 2 studies. Design/methods HFEM patients received either placebo or three once-monthly injections of 225 mg or 675 mg. Read More
Cephalalgia 2018 Jan 1:333102418774299. Epub 2018 Jan 1.
4 Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.
Premise Migraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood. Problem One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Read More
Cephalalgia 2018 Jan 1:333102418773076. Epub 2018 Jan 1.
2 The Emmes Corporation, Rockville, MD, USA.
Cephalalgia 2018 Jan 1:333102418771373. Epub 2018 Jan 1.
4 Royal Free London NHS Foundation Trust, London, UK.
Background Paroxysmal neurological symptoms occurring with sex cause considerable anxiety and sometimes have a serious cause. Thunderclap headache is the most well-known and requires urgent investigation at first presentation for subarachnoid haemorrhage and other significant pathologies. After exclusion of underlying causes, many prove to be primary headache associated with sexual activity. Read More
Cephalalgia 2018 Jan 1:333102418769917. Epub 2018 Jan 1.
2 Endocrinology, Diabetes and Metabolic Disease Unit, A.O. Ordine Mauriziano di Torino, Torino, Italy.
Background Recent studies suggested a potential association between both overt and subclinical hypothyroidism and migraine. Aims of this study were to estimate the comorbidity of migraine in patients with subclinical hypothyroidism and to evaluate associated clinical characteristics. Methods Using a case-control strategy, 151 consecutive subclinical hypothyroidism patients (mean age 48. Read More
Cephalalgia 2018 Jan 1:333102418772584. Epub 2018 Jan 1.
3 Universidad Rey Juan Carlos, Alcorcón, Spain.
Background Self-reported disability and pain intensity are commonly used outcomes in patients with cervicogenic headaches. However, there is a paucity of psychometric evidence to support the use of these self-report outcomes for individuals treated with cervicogenic headaches. Therefore, it is unknown if these measures are reliable, responsive, or result in meaningful clinically important changes in this patient population. Read More
Cephalalgia 2018 Jan 1:333102418771376. Epub 2018 Jan 1.
1 Global Research and Development, Teva Pharmaceuticals, Inc., Netanya, Israel.
Objectives The primary and secondary objectives of this phase 1 study were to evaluate the pharmacokinetic profile, safety, and immunogenicity of fremanezumab subcutaneous (sc) doses tested in phase 2 and 3 trials (225 mg, 675 mg and 900 mg) following single administration in Japanese (n = 32) and Caucasian (n = 32) healthy subjects. Methods Japanese and matched Caucasian healthy subjects were enrolled into one of four cohorts and were randomly assigned to one of four treatments: 225, 675, or 900 mg fremanezumab, or placebo. Pharmacokinetic and immunogenicity sampling, and safety and tolerability assessments occurred at one inpatient visit and 12 ambulatory visits during the 36-week study. Read More
Cephalalgia 2018 Jan 1:333102418771375. Epub 2018 Jan 1.
Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark.
Introduction Osmophobia has been suggested as an additional symptom of migraine without aura, and a high prevalence of osmophobia of up to 50% has been reported in the literature. We conducted a nosographic study of osmophobia in all migraineurs and tension-type headache patients and a field testing of suggested diagnostic criteria of osmophobia, presented in the appendix of the second edition of The International Classification of Headache Disorders and suggested by Silva-Néto et al. and Wang et al . Read More
Cephalalgia 2018 Jan 1:333102418767999. Epub 2018 Jan 1.
1 Headache Centre, Department of Neuroscience, University of Padova, Padova, Italy.
Background Migraine with aura may mimic an acute ischemic stroke, so that an improper administration of thrombolytic treatment can expose migrainous patients to severe adverse effects. Methods This systematic review quantifies the relevance of migraine with aura among stroke mimics, checking for thrombolysis' safety in these patients. We reviewed the literature after 1995, distinguishing from studies dealing with stroke mimics treated with systemic thrombolysis and those who were not treated with systemic thrombolysis. Read More
Cephalalgia 2018 Jan 1:333102418768087. Epub 2018 Jan 1.
2 University Hospital Essen, Headache Center, Essen, Germany.
Cephalalgia 2018 Jan 1:333102418769948. Epub 2018 Jan 1.
1 Department of Biomechanics, Medicine and Locomotor Apparatus Rehabilitation - Ribeirão Preto Medical School, 37884 University of São Paulo , Ribeirão Preto, Sao Paulo, Brazil.
Objective To assess the presence and handicap due to vestibular symptoms in three subgroups of patients with migraine and controls. Methods Women between 18-55 years old were diagnosed by headache specialists and stratified as migraine with aura (n = 60), migraine without aura (n = 60), chronic migraine (n = 60) and controls (n = 60). Information regarding demographics, headache and vestibular symptoms were collected in this cross-sectional study. Read More
Cephalalgia 2018 Jan 1:333102418756864. Epub 2018 Jan 1.
1 Division of Behavioral Medicine and Clinical Psychology, 2518 Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
Background Effective management of migraine requires adherence to treatment recommendations; however, adolescents with migraine take their daily medications only 75% of the time. Low-cost adherence-focused interventions using technology may improve adherence, but have not been investigated. Methods Thirty-five adolescents and young adults (13-21 years) with migraine participated in an AB-design pilot study to assess the use of a mobile phone adherence-promotion application ("app") and progressive reminder system. Read More
Cephalalgia 2018 Jan 1:333102418769955. Epub 2018 Jan 1.
2 Danish Headache Center, Department of Neurology, 70590 Rigshospitalet-Glostrup , University of Copenhagen, Copenhagen, Denmark.
Background The mechanisms behind the severe pain of cluster headache remain enigmatic. A distinguishing feature of the attacks is the striking rhythms with which they occur. We investigated whether statistical modelling can be used to describe 24-hour attack distributions and identify differences between subgroups. Read More
Cephalalgia 2018 Jan 1:333102418761047. Epub 2018 Jan 1.
1 Headache Science Center, IRCCS Mondino Foundation, Pavia, Italy.
Background and aim Factors implicated in the evolution of episodic migraine into chronic migraine are largely elusive. Medication overuse is considered to be one of the main determinants, but other possible clinical and psychological factors can play a role. The aim of this study is to identify factors that are associated with chronic migraine with medication overuse. Read More
Cephalalgia 2018 Jan 1:333102418769953. Epub 2018 Jan 1.
Department of Neurology, Mayo Clinic. Rochester, MN, USA.
Background The association of trigeminal neuralgia with pontine lesions has been well documented in multiple sclerosis, and we tested the hypothesis that occipital neuralgia in multiple sclerosis is associated with high cervical spinal cord lesions. Methods We retrospectively reviewed the records of 29 patients diagnosed with both occipital neuralgia and demyelinating disease by a neurologist from January 2001 to December 2014. We collected data on demographics, clinical findings, presence of C2-3 demyelinating lesions, and treatment responses. Read More
Cephalalgia 2018 Jan 1:333102418766872. Epub 2018 Jan 1.
1 Paediatric Department, 156727 Queen's University Hospital , London, UK.
Aim To examine the characteristics of visual symptoms during attacks of migraine in children and adolescents. Method A qualitative analysis of prospectively collected data over 5 years, on characteristics of visual symptoms during migraine attacks. Diagnosis of migraine and aura was based on the International Classification of Headache Disorders 3 edition beta version. Read More
Cephalalgia 2018 Jan 1:333102418769940. Epub 2018 Jan 1.
5 Department of Neurology and FORMI; Oslo University Hospital, Oslo, Norway.
Objectives To estimate remission rates of chronic headache and predictors of remission. Methods In this longitudinal population-based cohort study, we used validated headache questionnaire data from the second (1995-1997, baseline; n = 51,856 aged ≥ 20 years, response rate: 55%) and third wave (2006-2008, follow-up, response rate: 42%) of the Nord-Trøndelag Health Study. Chronic headache was defined as ≥15 headache days/month during the last year. Read More
Cephalalgia 2018 Jan 1:333102418768095. Epub 2018 Jan 1.
1 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, 4616 King's College London , London, UK.
Background A better understanding of the mechanisms underlying the migraine attack has reinforced the concept that migraine is a complex brain disease, and has paved the way for the development of new migraine specific acute treatments. In recent years, targeting the calcitonin gene-related peptide and its receptors has been one of the most promising pharmacological strategies for both acute and preventive treatment of migraine. Findings Randomized double-blind placebo-controlled trials have demonstrated the superiority of small molecule calcitonin gene-related peptide receptor antagonists (gepants) over placebo in treating acute migraine attacks measured as the two-hour pain free endpoint. Read More
Cephalalgia 2018 Apr;38(4):809-810
Cephalalgia 2018 Jan 1:333102418768037. Epub 2018 Jan 1.
4 Department of Medicine, Division of Pulmonary Medicine, University of California, San Francisco, CA, USA.
Objective To describe the frequency of migraine and predictors of having migraine in sarcoidosis patients. Methods The ID migraine questionnaire was administered to a well-phenotyped observational cohort of sarcoidosis patients (most of whom were seeking specialty care) and healthy controls. Predictors of migraine status were examined using univariate and multivariable logistic regression. Read More
Cephalalgia 2018 Jan 1:333102418768077. Epub 2018 Jan 1.
4 NESMOS Department, Sapienza University, Rome, Italy.
Cephalalgia 2018 Jan 1:333102418765787. Epub 2018 Jan 1.
1 School of Biological Sciences, 1415 University of Auckland , Auckland, New Zealand.
Background Calcitonin gene-related peptide is an important target for migraine and other painful neurovascular conditions. Understanding the normal biological functions of calcitonin gene-related peptide is critical to understand the mechanisms of calcitonin gene-related peptide-blocking therapies as well as engineering improvements to these medications. Calcitonin gene-related peptide is closely related to other peptides in the calcitonin gene-related peptide family of peptides, including amylin. Read More
Cephalalgia 2018 Jan 1:333102418766869. Epub 2018 Jan 1.
1200 Binz #1370 Houston, TX 77004, USA.