429 results match your criteria Central-European journal of immunology[Journal]


Biclonal myeloma in renal failure.

Cent Eur J Immunol 2020 ;45(1):122-124

University Hospital Alexandrovska, Sofia, Bulgaria.

Multiple myeloma is a clonal proliferation of the plasma cell line that accounts for approximately 10% of all hematological malignancies. It is characterized by abnormal growth of plasma cells producing monoclonal immunoglobulin or light chain (paraprotein), with subsequent development of osteolytic bone lesions, anemia, hypercalcemia, and renal failure. In 3-6% of myeloma patients, more than one monoclonal protein (usually two) is discovered, with different heavy or light chain or both. Read More

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http://dx.doi.org/10.5114/ceji.2020.94714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226549PMC
January 2020

Successful reconstitution of leukocyte adhesion defect after umbilical cord blood stem cell transplant.

Cent Eur J Immunol 2020 ;45(1):117-121

Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.

Leukocyte adhesion deficiencies (LADs) are a type of primary immunodeficiencies characterized by delayed detachment of the umbilical cord, impaired wound healing, leukocytosis, and recurrent infections. The disease is caused by genetic defects affecting different steps in the process of leukocyte adhesion cascade such as rolling, integrin activation, and adhesion of leukocytes, resulting in the impairment of leukocyte trafficking. Till date, three types of LAD have been documented: type I, II and III. Read More

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http://dx.doi.org/10.5114/ceji.2020.94713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226562PMC
January 2020

Infection-induced innate antimicrobial response disorders: from signaling pathways and their modulation to selected biomarkers.

Cent Eur J Immunol 2020 ;45(1):104-116

Department of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.

Severe infections are a major public health problem responsible for about 40-65% of hospitalizations in intensive care units (ICU). The high mortality (30-50%) of persons diagnosed with severe infection is caused by largely unknown mechanisms of sepsis-induced immune system response. Severe infections with dynamic progress are accompanied with SIRS (systemic inflammatory reaction syndrome) and CARS (compensatory anti-inflammatory response syndrome), and require a biological treatment appropriate to the phase of immune response. Read More

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http://dx.doi.org/10.5114/ceji.2020.94712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226557PMC
January 2020

Understanding the early host immune response against .

Authors:
Babban Jee

Cent Eur J Immunol 2020 ;45(1):99-103

Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, India.

Generation of immune response is a crucial activity of host defense against any microbial attack. When facultative organism Mycobacterium tuberculosis (MTB) invades its host, various pathways are activated in the host to mount immune responses against invading pathogen for nullifying its actions. During this host-pathogen interaction, interplay of complex network of cytokines and chemokines, initiation of phagocytosis, and formation of granuloma play an important role in containing MTB infections at host side. Read More

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http://dx.doi.org/10.5114/ceji.2020.94711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226546PMC
January 2020

Systemic lupus erythematosus and glycation process.

Cent Eur J Immunol 2020 ;45(1):93-98

nd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.

Systemic lupus erythematosus (SLE) is a disease of unclear causes, which leads to major immunological disorders. It is characterized by an abnormal immune system activity resulting in the production of autoantibodies. In patients, antibodies targeting normal nuclear components, double-stranded DNA (dsDNA), and phospholipids (cardiolipin) can be detected. Read More

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http://dx.doi.org/10.5114/ceji.2018.77875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226551PMC
January 2020
0.358 Impact Factor

Circulation autoantibodies against C-terminus of NuMA in patients with Behçet's disease.

Cent Eur J Immunol 2020 ;45(1):86-92

112 Lab, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.

Circulating autoantibodies have a close association with autoimmune diseases, which may be seen even in healthy individuals. These are also considered as promising source of new biomarkers in various autoimmune diseases. However, their profile is not completely understood till now. Read More

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http://dx.doi.org/10.5114/ceji.2020.94710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226561PMC
January 2020

Genetic association of polymorphism rs2230054 in gene with gout in Chinese Han male population.

Cent Eur J Immunol 2020 ;45(1):80-85

Department of Central Lab, Qingdao Municipal Hospital, Qingdao, Shandong, China.

Neutrophils are crucial in the process of gout flare and remission. The signal transduction pathway of chemokine plays a vital role in the chemotaxis and activation of neutrophils. CXCR2 gene knocked out can avoid the acute neutrophilic inflammation stimulated by monosodium urate (MSU) crystals in mice. Read More

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http://dx.doi.org/10.5114/ceji.2020.94702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226559PMC
January 2020

Joint remodeling outcome of serum levels of Dickkopf-1 (DKK1), cartilage oligomeric matrix protein (COMP), and C-telopeptide of type II collagen (CTXII) in rheumatoid arthritis.

Cent Eur J Immunol 2020 ;45(1):73-79

Department of Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospital, Assiut, Egypt.

Introduction: Rheumatoid arthritis (RA) is the most widespread chronic inflammatory rheumatic disease over the world. It is characterized by chronic proliferation of synovium, cartilage destruction, and periarticular erosion/bone loss. We investigated the serum levels of the C-telopeptide of type II collagen (CTX-II), Dickkopf-1 (DKK1), and cartilage oligomeric matrix protein (COMP) in relationship to the disease activity. Read More

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http://dx.doi.org/10.5114/ceji.2020.94685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226550PMC
January 2020
0.358 Impact Factor

Do microdeletions lead to immune deficiency?

Cent Eur J Immunol 2020 ;45(1):69-72

Department of Pediatric Allergy and Immunology, Dr Behçet Uz Children's Hospital, Izmir, Turkey.

Introduction: Microdeletion syndromes may be accompanied by immunological disorders. This study aimed to evaluate the clinical and laboratory data as well as the immune functions of patients diagnosed with a microdeletion syndrome.

Material And Methods: 39 patients diagnosed with microdeletion syndrome who were monitored at the Pediatric Genetics and Immunology clinics at Dr. Read More

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http://dx.doi.org/10.5114/ceji.2020.94671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226555PMC
January 2020

Changes in the Th9 cell population and related cytokines in the peripheral blood of infants with recurrent wheezing.

Cent Eur J Immunol 2020 ;45(1):60-68

Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Introduction: T helper type 9 (Th9) cells have been shown to play a key role in initiating allergic reactions and promoting airway inflammation. However, to the best of our knowledge, their role has not been analyzed in infants with recurrent wheezing.

Material And Methods: We performed a case-control study including 34 infants with recurrent wheezing and the same number of healthy infants as controls; all subjects were aged 1- to 3-years-old. Read More

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http://dx.doi.org/10.5114/ceji.2020.94683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226556PMC
January 2020

Does adiponectin play a role in the pathogenesis of chronic spontaneous urticaria?

Cent Eur J Immunol 2020 ;45(1):56-59

Department of Internal Diseases, Allergology and Clinical Immunology, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, Poland.

Introduction: Chronic spontaneous urticaria constitutes an interdisciplinary problem and its pathogenesis is still a subject of debate. Overweight and hyperlipidemia are supposed to be related to chronic spontaneous urticaria. Fatty tissue can be the source of adipokines. Read More

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http://dx.doi.org/10.5114/ceji.2020.94678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226560PMC
January 2020

CSF levels of myelin basic protein in pediatric patients with ventriculoperitoneal shunt infection.

Cent Eur J Immunol 2020 ;45(1):48-55

Polish Mother's Memorial Hospital Research Institute, Łódź, Poland.

Introduction: Hydrocephalus is a common disorder of the central nervous system (CNS) in the pediatric population. Surgical treatment options involve ventriculoperitoneal shunt (VPS) placement. VPS infection is the most common complication of surgically treated hydrocephalus in pediatric patients [1, 2],which may lead to neuronal damage. Read More

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http://dx.doi.org/10.5114/ceji.2020.94682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226547PMC
January 2020

Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy.

Cent Eur J Immunol 2020 ;45(1):37-47

Department of Urology and Urological Oncology, Wroclaw Medical University, Wroclaw, Poland.

Introduction: The present study investigated the association of cytokines genes polymorphisms (IL-2, IL-8 and IL-18) and polymorphisms in genes encoding molecules related to the differentiation of Th17 subpopulation (IL-17 and IL-23R) with the risk of bladder cancer (BC) and response to BCG immunotherapy.

Material And Methods: Altogether, 175 BC patients treated with BCG due to high-grade non-muscle invasive tumors and 207 healthy individuals were genotyped for the following polymorphisms: IL-17A-197G>A (rs2275913); IL-17F+7488T>C (rs763780); IL-23Rc.309C>A (rs10889677);IL-23Rc. Read More

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http://dx.doi.org/10.5114/ceji.2020.94674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226548PMC
January 2020

Th17 and regulatory T cells in patients with different time of progression of type 2 diabetes mellitus.

Cent Eur J Immunol 2020 ;45(1):29-36

Department of Medicine and Nutrition, Division of Health Sciences, Campus León, University of Guanajuato, Guanajuato, México.

Introduction: Type 2 diabetes mellitus (T2DM) is characterized by chronic inflammation, in which different types of immune cells participate, such as TH17 cells and Treg cells. The aim of this study was to determine the relationship between Treg and Th17 in patients with different times of T2DM progression.

Material And Methods: Nineteen control subjects and 40 patients with T2DM were included. Read More

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http://dx.doi.org/10.5114/ceji.2020.94670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226552PMC
January 2020

sequence variant and elevated gene expression are associated with type 1 diabetes in Polish children.

Cent Eur J Immunol 2020 ;45(1):22-28

Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic β cells, resulting from coincident genetic predisposition and some environmental triggers. Signal transducer and activator of transcription 4 (STAT4) gene encodes a transcription factor, which promotes Th1 cell differentiation, interferon γ production, and development of Th17 cells. Polymorphisms of STAT4 are associated with several autoimmune conditions, while studies in T1D provided inconsistent results. Read More

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http://dx.doi.org/10.5114/ceji.2019.92492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226553PMC
January 2020

Uncoupling protein-2 regulates M1 macrophage infiltration of gingiva with periodontitis.

Cent Eur J Immunol 2020 ;45(1):9-21

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Periodontitis is an inflammatory disease accompanied by alveolar bone loss. Moreover, M1 macrophages play a critical role in the development of periodontal disease. Uncoupling protein-2 (UCP2) is a mitochondrial transporter protein that controls M1 macrophage activation by modulating reactive oxygen species (ROS) production. Read More

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http://dx.doi.org/10.5114/ceji.2020.94664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226558PMC
January 2020

The significance of as an immunomodulator of the level of IL-17 in Balb/C mice with atherosclerosis.

Cent Eur J Immunol 2020 ;45(1):1-8

Biology Department, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang, Indonesia.

Atherosclerosis is a disease caused by an inflammatory response which involved the interaction between endothelial cells, macrophages and lymphocytes, and is closely related to IL-17 regulation. This study is important to investigate the activity of Agaricusblazei in modulating the immunological activity based on the profile of CD4IL-17, CD8IL-17, and CD11b IL-17 in high-fat diet (HFD)-induced Balb/c mice. Mice in dietary groups were fed with HFD and then fed with A. Read More

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http://dx.doi.org/10.5114/ceji.2020.94662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226554PMC
January 2020

Reduced GLP-1 response to a meal is associated with the rs3087243 genotype.

Cent Eur J Immunol 2019 30;44(3):299-306. Epub 2019 Sep 30.

2 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

Although insulitis is the characteristic main feature of type 1 diabetes mellitus (T1DM), many aspects of cell loss still remain elusive. Immune dysregulation and alterations in the dipeptidyl-peptidase-4-incretin system might have a role in disease development, but their connection is poorly understood. We assessed the associations of a few selected, immunologically relevant single nucleotide gene variants with the DPP-4-incretin system in individuals with T1DM and in healthy controls. Read More

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http://dx.doi.org/10.5114/ceji.2019.89604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953372PMC
September 2019

Tumour necrosis factor gene polymorphisms in Egyptian patients with rheumatoid arthritis and their relation to disease activity and severity.

Cent Eur J Immunol 2019 30;44(3):277-284. Epub 2019 Sep 30.

Department of Rheumatology and Rehabilitation, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.

Aim Of The Study: The present case control study was conducted to assess the association of LTA 252 A>G, TNF-α 308 G>A, and TNF-α 1031 T>C gene polymorphisms with rheumatoid arthritis (RA), and their involvement in disease activity and severity.

Material And Methods: A total of 70 Egyptians, including 35 RA patients and 35 healthy control individuals, were included in the study. The RA patients comprised 34 females and one male. Read More

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http://dx.doi.org/10.5114/ceji.2019.89602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953370PMC
September 2019

Salivary interleukin 6, interleukin 8, interleukin 17A, and tumour necrosis factor α levels in patients with periodontitis and rheumatoid arthritis.

Cent Eur J Immunol 2019 30;44(3):269-276. Epub 2019 Sep 30.

Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, Warsaw, Poland.

Introduction: Rheumatoid arthritis (RA) and periodontitis share risk factors and inflammatory pathways that could be related to cytokines, such as interleukin (IL)-6, IL-8, IL-17A, and tumour necrosis factor- (TNF-). The aim of this study was to compare periodontal status and salivary levels of selected cytokines between patients diagnosed with RA and periodontitis. RA patients were assessed for the potential influence of anti-rheumatic therapy. Read More

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http://dx.doi.org/10.5114/ceji.2019.89601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953371PMC
September 2019

Prognostic value of serum and urine kidney injury molecule-1 in infants with urinary tract infection.

Cent Eur J Immunol 2019 30;44(3):262-268. Epub 2019 Sep 30.

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Kidney injury molecule-1 (KIM-1) is an important diagnostic and prognostic marker in acute kidney injury and chronic kidney disease of various aetiologies. The aim of the study was to evaluate the usefulness of serum KIM-1 (sKIM-1) and urine KIM-1 (uKIM-1) for predicting febrile and non-febrile urinary tract infection (UTI) in infants.

Material And Methods: A prospective study included 101 children divided into three groups: febrile UTI 49 children, non-febrile UTI 22 children, and healthy controls 30 children. Read More

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http://dx.doi.org/10.5114/ceji.2019.89600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953373PMC
September 2019

The associations between interleukin 10 polymorphisms and susceptibility to autoimmune uveitis - a meta-analysis.

Cent Eur J Immunol 2019 30;44(3):246-252. Epub 2019 Sep 30.

Division of Rheumatology, Korea University Medical Centre, Seoul, South Korea.

Autoimmune uveitis is an ocular inflammatory disease that is associated with genetic factors. Interleukin 10 (IL-10) is an immune-regulatory cytokine of autoimmune diseases. IL-10 is considered a candidate gene for uveitis. Read More

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http://dx.doi.org/10.5114/ceji.2019.89596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953374PMC
September 2019

Sulfur dioxide reduces lipopolysaccharide-induced acute lung injury in rats.

Cent Eur J Immunol 2019 30;44(3):226-236. Epub 2019 Sep 30.

Department of Pathophysiology, Hebei Medical University, Shijiazhuang, China.

Introduction: Recent studies suggested that sulfur dioxide (SO2) can be produced endogenously by pulmonary vessels and attenuate acute lung injury (ALI) with vasorelaxant effects. This study was conducted to determine whether SO2 can inhibit lung inflammation and relax pulmonary arteries via inhibition of the mitogen-activated protein kinase (MAPK) pathway.

Material And Methods: Forty-eight adult male Sprague Dawley rats (250~300 g) were randomly divided into six treatment groups: control (n = 8), control + SO2 (n = 8), control + L-aspartic acid--hydroxamate (HDX) (n = 8), LPS (n = 8), LPS + SO2 (n = 8) and LPS + HDX (n = 8). Read More

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http://dx.doi.org/10.5114/ceji.2019.89593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953369PMC
September 2019

Congratulations to Professor Czesław Radzikowski.

Cent Eur J Immunol 2019 30;44(3):336. Epub 2019 Sep 30.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.

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http://dx.doi.org/10.5114/ceji.2019.89614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925562PMC
September 2019

Development of multiple gallstones in a child with lipopolysaccharide-responsive beige-like anchor protein mutation.

Cent Eur J Immunol 2019 30;44(3):332-335. Epub 2019 Sep 30.

Department of Paediatric Immunology and Allergy, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

A defect in the lipopolysaccharide-responsive beige-like anchor protein (LRBA) gene is a newly defined rare cause of primary immunodeficiency diseases, which manifests as immune dysregulation and humoral immune deficiency. LRBA deficiency is a combined immunodeficiency. A boy with LRBA deficiency is described in this report. Read More

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http://dx.doi.org/10.5114/ceji.2019.89613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925566PMC
September 2019

Complex profile of multiple hepatobiliary and gastrointestinal complications after hematopoietic stem cell transplantation in a child with Nijmegen breakage syndrome.

Cent Eur J Immunol 2019 30;44(3):327-331. Epub 2019 Sep 30.

Department of Paediatrics, Haematology and Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Antoni Jurasz University Hospital No. 1, Bydgoszcz, Poland.

Patients with Nijmegen breakage syndrome (NBS) can develop life-threatening immunodeficiency, which should be treated with hematopoietic stem cell transplantation (HSCT). We report the case of a 14-year-old girl with NBS who due to an increasing number of severe complications was referred for HSCT from a matched unrelated donor. After reduced-intensity conditioning and transplantation of peripheral blood hematopoietic cells, during the early post-transplant period (days 0-30), the girl suffered from severe mucositis, fever episodes, mild acute renal injury and facial vasculitis. Read More

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http://dx.doi.org/10.5114/ceji.2019.89612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925563PMC
September 2019

Immunological characterization of the American cockroach allergen Per a 9 expressed in baculovirus-infected insect cells.

Cent Eur J Immunol 2019 30;44(3):322-326. Epub 2019 Sep 30.

Research Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

American cockroach (CR) allergy has been recognized as important IgE-mediated type I hypersensitivity. Per a 9 is an arginine kinase, reacting with IgE in sera of all CR allergic Thai patients. Per a 9 gene was cloned and expressed in eukaryotic systems (baculovirus-infected insect cells). Read More

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http://dx.doi.org/10.5114/ceji.2019.89611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925565PMC
September 2019
0.358 Impact Factor

Comparison of T and NK lymphocyte subsets between human endometrial tissue and peripheral blood.

Cent Eur J Immunol 2019 30;44(3):316-321. Epub 2019 Sep 30.

Reproductive Medicine Clinic "Nadiya", Kyiv, Ukraine.

Immune profiles in endometrium may be changed in patients with IVF failure and its possible correlations with immune parameters in peripheral blood are important for the diagnostic approach. Such correlations in healthy women are unknown and have been studied in the present research. The expression of CD56, CD158a, HLA DR, CD69 in T lymphocytes, CD4 T lymphocytes, CD8+ T lymphocytes and NK cells were studied by flow-cytometry in endometrium and peripheral blood in healthy 24 donors of oocytes aged 25-32 years. Read More

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http://dx.doi.org/10.5114/ceji.2019.89610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925561PMC
September 2019

Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight.

Cent Eur J Immunol 2019 30;44(3):307-315. Epub 2019 Sep 30.

Department of Paediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Aim Of The Study: To assess the changes in the leukocyte profile and C-reactive protein (CRP) concentration in adolescents with excess fat mass after 6-12 months of dietary intervention.

Material And Methods: The retrospective study included 99 overweight and obese adolescents, aged from 10.0 to 17. Read More

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http://dx.doi.org/10.5114/ceji.2019.89608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925564PMC
September 2019

Analysis of the level of selected parameters of inflammation, circulating immune complexes, and related indicators (neutrophil/lymphocyte, platelet/lymphocyte, CRP/CIC) in patients with obstructive diseases.

Cent Eur J Immunol 2019 20;44(3):292-298. Epub 2019 Sep 20.

Department of Lung Diseases, Cancer and Tuberculosis, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Introduction: Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder of the airways. An important element of COPD assessment is the evaluation of immune mechanisms involved in non-specific and specific response to ongoing inflammation.

Aim Of The Study: To evaluate the level of selected inflammatory and immunological parameters in patients with COPD, including C-reactive protein (CRP) and circulating immune complexes (CIC), as well as CRP/CIC index. Read More

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http://dx.doi.org/10.5114/ceji.2019.87498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925570PMC
September 2019

Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level.

Cent Eur J Immunol 2019 30;44(3):285-291. Epub 2019 Sep 30.

Beni-Suef University, Beni-Suef, Egypt.

Introduction: Bronchial asthma is a chronic inflammatory disease. Interleukin 18 (IL-18) single nucleotide polymorphisms (SNPs) can influence IL-18 production and activity. IL-18-607C/A and -137 C/G are two of the commonly studied SNPs of IL-18 due to their role in the etiopathogenesis of allergic diseases. Read More

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http://dx.doi.org/10.5114/ceji.2019.89603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925568PMC
September 2019

Markers of endothelial injury and subclinical inflammation in children and adolescents with primary hypertension.

Cent Eur J Immunol 2019 30;44(3):253-261. Epub 2019 Sep 30.

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Adhesion molecules: E-selectin and intercellular adhesion molecule 1 (ICAM-1) are well-established markers of endothelial injury. The aim of the study was to assess the relation between E-selectin and ICAM-1 and clinical and biochemical parameters in children and adolescents with primary hypertension (PH).

Material And Methods: In 77 patients with PH (15. Read More

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http://dx.doi.org/10.5114/ceji.2019.89597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925569PMC
September 2019

Not only anti-inflammation, etanercept abrogates collagen-induced arthritis by inhibiting dendritic cell migration and maturation.

Cent Eur J Immunol 2019 30;44(3):237-245. Epub 2019 Sep 30.

Department of Rheumatology and Immunology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.

The application of tumor necrosis factor inhibitors (TNFi) is a major breakthrough in the treatment of rheumatoid arthritis (RA). While the anti-inflammatory nature of TNFi is thought to contribute to the therapeutic effects, recent data show that the pharmacology of TNF- blockade is probably more complex than previously thought. This study investigates whether etanercept (ETN), one of the TNF antagonists, suppresses arthritis development through modulation of dendritic cell (DC) functions. Read More

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http://dx.doi.org/10.5114/ceji.2019.89595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925567PMC
September 2019

A study of the utility of novel non-invasive urinary and serum biomarkers of blunt kidney injury in a rat model: NGAL, KIM-1, and IL-18.

Cent Eur J Immunol 2019 30;44(3):219-225. Epub 2019 Sep 30.

Department of Pediatric Surgery, Faculty of Medicine, Firat University, Elaz|ǧ, Turkey.

This study investigated changes in the concentrations of serum and urine neutrophil gelatinase lipocalin (NGAL), kidney injury molecule 1 (KIM-1), interleukin 18 (IL-18), and cystatin-C (Cys-C) induced by parenchymal and tubular damage following blunt kidney trauma, as well as their potential utility as biomarkers in the detection and follow-up of patients with suspected blunt renal trauma. Three-month-old male Sprague-Dawley rats (n = 18) were divided into three groups (n = 6 in each): group 1: control group (no intervention); group 2: sham group (explorative surgery and exposure of the left kidneys); and group 3: trauma group (explorative surgery and induction of blunt renal trauma of the left kidneys). Serum and urine samples were collected before and 12-24, 36-48, and 60-72 hours later for NGAL, KIM-1, IL-18, and Cys-C measurements. Read More

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http://dx.doi.org/10.5114/ceji.2019.89592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925560PMC
September 2019

Serum levels of interleukin 33 and its receptor ST2 in patients treated with subcutaneous allergen immunotherapy in intermittent allergic rhinitis.

Cent Eur J Immunol 2019 30;44(2):214-217. Epub 2019 Jul 30.

Chair and Clinical Department of Internal Diseases, Allergology, and Clinical Immunology, Medical University of Silesia, Katowice, Poland.

Introduction: Interleukin 33 (IL-33) is a pleiotropic cytokine involved in pathological processes in seasonal allergic rhinitis. IL-33 binds to ST2 receptor, which is highly expressed on mast cells and selectively on Th2 cells. Information is lacking on the role of IL-33/ST2 axis in allergen subcutaneous immunotherapy. Read More

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http://dx.doi.org/10.5114/ceji.2019.87075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745539PMC
July 2019
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A case of bizarre posttransplant anti-glomerular basement membrane disease.

Cent Eur J Immunol 2019 30;44(2):210-213. Epub 2019 Jul 30.

Department of Immunology, Poznan University of Medical Sciences, Poland.

The non-collagenous (NC1) domain of α3 and α5 chains of type IV collagen are eminent targets of abnormal immune response in anti-glomerular basement membrane (anti-GBM) disease, which can be diagnosed by the presence of strong linear IgG staining along GBM detected by direct immunofluorescence. The presence of linear GBM fixation in renal allograft is a rare finding. We observed a 33-year-old male with de novo renal failure in a kidney transplant. Read More

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http://dx.doi.org/10.5114/ceji.2019.87074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745540PMC
July 2019
8 Reads
0.358 Impact Factor

Late diagnosis of leukocyte adhesion deficiency type II and Bombay blood type in a child: a rare case report.

Cent Eur J Immunol 2019 30;44(2):206-209. Epub 2019 Jul 30.

Division of Paediatric Haematology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.

Leukocyte adhesion deficiency type II (LAD II) is a rare, autosomal, recessive inherited immunodeficiency disease that induces frequent and recurrent infections, persistent leukocytosis, severe mental and growth retardation, and impaired wound healing. The Bombay blood group is a rare blood group phenotype that is characterised by the deficiency of H, A, and B antigens on the surface of red cells. LAD II and the Bombay blood group are always seen together, because both of them are associated with a global defect in the common pathway of fucose metabolism. Read More

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https://www.termedia.pl/doi/10.5114/ceji.2019.87073
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http://dx.doi.org/10.5114/ceji.2019.87073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745544PMC
July 2019
3 Reads

Melanomacrophages and melanomacrophage centres in .

Cent Eur J Immunol 2019 30;44(2):201-205. Epub 2019 Jul 30.

Centre for Veterinary Sciences, Nicolaus Copernicus University in Torun, Poland.

Melanomacrophages (MMs) are phagocytizing cells with high amounts of pigments including melanin which can be found in a number of cold-blooded species. In Osteichthyes, these cells cluster to form so-called melanomacrophage centres (MMCs), which are predominantly present in the stroma of hematopoietic and lymphoid tissues, that is, in the kidney and spleen. The functionality of MMs and MMCs results from their involvement and role in the defence reactions, related to both the innate and the adaptive immune mechanisms, and in processes unrelated to defence functions as well. Read More

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http://dx.doi.org/10.5114/ceji.2019.87072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745537PMC

Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor β on cancer cells.

Cent Eur J Immunol 2019 30;44(2):190-200. Epub 2019 Jul 30.

Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Poland.

Cytokines are signalling proteins generated in most part by immune cells that have critical functions in cellular lifespan. Here we present recent data on three selected anti-inflammatory cytokines: interleukin (IL)-10, IL-4 and transforming growth factor β (TGF-β). IL-10 inhibits the synthesis of major pro-inflammatory cytokines, chemokines, and mediates anti-inflammatory reactions. Read More

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http://dx.doi.org/10.5114/ceji.2018.76273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745546PMC

Therapeutic potential of curcumin in eye diseases.

Cent Eur J Immunol 2019 30;44(2):181-189. Epub 2019 Jul 30.

Department of Histology and Embryology, Medical University of Warsaw, Poland.

Curcumin (diferuloylmethane) derived from the rhizome of Curcuma longa L. has been used for thousands of years in traditional Chinese medicine and Ayurvedic medicine in Asian countries to treat liver diseases, rheumatoid diseases, diabetes, atherosclerosis, infectious diseases and cancer. It exhibits a wide range of pharmacological properties, which include antioxidant, anti-inflammatory, antimutagenic, antimicrobial and anticancer activity. Read More

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http://dx.doi.org/10.5114/ceji.2019.87070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745545PMC
July 2019
3 Reads

Diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin and urine kidney injury molecule-1 as predictors of acute pyelonephritis in young children with febrile urinary tract infection.

Cent Eur J Immunol 2019 30;44(2):174-180. Epub 2019 Jul 30.

Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.

Introduction: We assessed whether two urinary biomarkers of acute kidney injury, neutrophil gelatinase associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1), can be useful for predicting acute pyelonephritis (APN) in children aged 1-24 months with the first febrile urinary tract infection (UTI).

Material And Methods: A prospective study included 54 children divided into two groups (24 with APN, 30 with lower UTI), according to the dimercaptosuccinic acid (DMSA) renal scintigraphy results. Laboratory tests: uNGAL, uKIM-1, procalcitonin (PCT), C-reactive protein (CRP), white blood count (WBC) were performed. Read More

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http://dx.doi.org/10.5114/ceji.2019.87069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745542PMC
July 2019
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Associations of rs10818488 and rs3761847 polymorphisms with genetic susceptibility to rheumatoid arthritis: a case-control study and updated meta-analysis.

Cent Eur J Immunol 2019 30;44(2):159-173. Epub 2019 Jul 30.

Department of Rheumatology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, Zhejiang, China.

The results on associations of tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 (TRAF1/C5) rs10818488 and rs3761847 polymorphisms with rheumatoid arthritis (RA) are controversial, thus this study was performed to examine whether the aforementioned polymorphisms were associated with RA in a Chinese population. Furthermore, an updated meta-analysis was conducted. The polymorphisms were genotyped in 328 Chinese RA patients and 449 healthy controls. Read More

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http://dx.doi.org/10.5114/ceji.2019.87067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745538PMC
July 2019
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Correlations between serum interleukin 6, serum soluble interleukin 6 receptor, and disease activity in systemic juvenile idiopathic arthritis patients treated with or without tocilizumab.

Cent Eur J Immunol 2019 30;44(2):150-158. Epub 2019 Jul 30.

Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: Interleukin (IL)-6 is a proinflammatory cytokine involved in systemic juvenile idiopathic arthritis (SJIA). Since these patients are often treated with tocilizumab (TCZ), anti-IL-6 receptor (IL-6R) antibody, we investigated correlations between serum IL-6 and soluble IL-6R-levels and disease activity in SJIA patients treated with or without TCZ.

Material And Methods: 164 serum samples were taken from 42 SJIA patients treated with or without TCZ (69 and 95 samples, respectively). Read More

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http://dx.doi.org/10.5114/ceji.2019.87066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745541PMC
July 2019
2 Reads

Increased risks between TLR2 (-196 to -174 ins/del) and TLR3 1377C>T variants and head and neck cancers in Tunisia.

Cent Eur J Immunol 2019 30;44(2):144-149. Epub 2019 Jul 30.

Laboratory of Mycology, Pathologies, and Biomarkers: LR16ES05, Department of Biology, Faculty of Sciences, El Manar University, Tunis, Tunisia.

Introduction: Previous studies have highlighted the importance of polymorphisms of toll-like receptors (TLRs) in the pathogenesis of certain cancers, including head and neck cancers (HNC).

Aim Of The Study: The aim of this study was to evaluate the association of TLR2 (-196 to -174 ins/del) and TLR3 (1377 C>T) as potential risk factors for HNC in Tunisians.

Material And Methods: A case-control study including 246 HNC patients (174 nasopharyngeal carcinoma - NPC and 72 laryngeal cancer - LC) and 250 healthy controls. Read More

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http://dx.doi.org/10.5114/ceji.2019.87065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745549PMC
July 2019
2 Reads
0.358 Impact Factor

Diagnosis and treatment of adult mixed-type Henoch-Schönlein purpura.

Cent Eur J Immunol 2019 30;44(2):138-143. Epub 2019 Jul 30.

Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai, China.

Aim Of The Study: The purpose of this study was to investigate the clinical manifestations and outcomes of patients with adult mixed-type Henoch-Schönlein purpura (HSP) and imaging characteristics of the disease, and to evaluate the efficacy of combined therapy in treating symptoms of HSP.

Material And Methods: From January 2008 to October 2015, 23 patients with adult mixed-type HSP were enrolled. Abdominal contrast-enhanced computed tomography (CT) examination and small intestinal enteroscopy were performed for all the patients. Read More

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http://dx.doi.org/10.5114/ceji.2019.87064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745548PMC
July 2019
9 Reads

Peripheral blood picture and aminotransferase activity in children with newly diagnosed Graves' disease at baseline and after the initiation of antithyroid drug therapy.

Cent Eur J Immunol 2019 30;44(2):132-137. Epub 2019 Jul 30.

Department of Paediatrics and Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Aim Of The Study: Assessment of the peripheral blood picture and aminotransferase activity in children with newly diagnosed Graves' disease (GD) at baseline and 4-6 weeks after the initiation of antithyroid drug (ATD) therapy.

Material And Methods: Data of 59 children were assessed retrospectively. Baseline analysis included concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), TSH receptor antibodies (TSH-R Ab), complete blood cell count (CBC), aspartate (AST) and alanine aminotransferase (ALT) activity. Read More

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http://dx.doi.org/10.5114/ceji.2019.87063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745550PMC
July 2019
1 Read

MiR-214 regulates CD3ζ expression in T cells.

Cent Eur J Immunol 2019 30;44(2):127-131. Epub 2019 Jul 30.

Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.

Introduction: T-cell activation requires the T-cell receptor (TCR)-CD3 complex, which integrates and transduces signals. CD3ζ plays a vital role in TCR signalling by mediating T-cell activation. Abnormal CD3ζ expression is a common characteristic of haematological malignancies with T-cell immune dysfunction or autoimmune diseases. Read More

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http://dx.doi.org/10.5114/ceji.2019.87061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745543PMC
July 2019
4 Reads

Characteristics of the patients followed with the diagnosis of common variable immunodeficiency and the complications.

Cent Eur J Immunol 2019 30;44(2):119-126. Epub 2019 Jul 30.

Department of Pediatric Allergy and Immunology, Istambul Medipol University, Istambul, Turkey.

Introduction: In this study, we aimed to retrospectively evaluate the clinical and laboratory findings and complications of 28 common variable immunodeficiency (CVID) patients.

Material And Methods: The clinical features and laboratory data of 28 CVID patients were evaluated.

Results: Nineteen patients were male. Read More

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http://dx.doi.org/10.5114/ceji.2019.87060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745547PMC
July 2019
2 Reads

Effect of selected non-steroidal anti-inflammatory drugs on activation-induced CD25 expression on murine CD4 and CD8 T cells: an study.

Cent Eur J Immunol 2019 30;44(2):109-118. Epub 2019 Jul 30.

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland.

The main aim of this study has been to determine the effect of selected non-steroidal anti-inflammatory drugs (NSAIDs) - depending on their selectivity to cyclooxygenase (COX) 1 and 2 - on the activation-induced CD25 expression on CD4 and CD8 T cells. Lymphocytes obtained from lymph nodes of mice were treated with acetylsalicylic acid (ASA; a preferential COX-1 inhibitor), ketoprofen (KET; a non-selective COX inhibitor) and robenacoxib (ROB; a selective COX-2 inhibitor) in concentrations reflecting their plasma levels achieved in vivo at therapeutic doses and in ten-fold lower concentrations. The cells were activated with concanavalin A. Read More

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http://dx.doi.org/10.5114/ceji.2019.87058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745551PMC

IgA nephropathy associated with coeliac disease.

Cent Eur J Immunol 2019 15;44(1):106-108. Epub 2019 Apr 15.

Department of Nephrology, Transplantology and Internal Medicine, University of Medical Sciences, Poznań, Poland.

Coeliac disease (CD) is an autoimmune disorder of the small intestine triggered by ingested gluten from barley, rye and wheat. It can be associated with other autoimmune conditions, such as type 1 diabetes, autoimmune thyroiditis and hepatitis, Sjögren's syndrome and IgA nephropathy (IgAN). We describe here a case of a 24-year-old man with the above-mentioned atypical form of coeliac disease for whom the diagnosis started with renal disorder. Read More

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http://dx.doi.org/10.5114/ceji.2019.84021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526587PMC
April 2019
9 Reads