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Clin Neurol Neurosurg 2019 Mar 6;178:97-100. Epub 2019 Feb 6.

Kirikkale University, Faculty of Medicine, Department of Radiology, Kirikkale, Turkey.

Objective: The aim of this study was to investigate the relationship between basilar artery (BA) tortuosity, hypogenesis/agenesis of the vertebral artery (VA), and vertigo, with the use of magnetic resonance imaging (MRI).

Patients And Methods: This case-control study included patients admitted to the outpatient clinics, who were aged 18-80 years, without any known systemic diseases. All patients were evaluated with a 1. Read More

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Dep. of Neurosurgery and Neurooncology, Charles University in Prague, 1st Medical Faculty, Central Military Hospital Stresovice, Czech Republic. Electronic address:

Background: Pneumocephalus is commonly associated with cranial trauma including surgical interventions. Spontaneous pneumocephalus on the other hand is a rare diagnosis. Reported cases were predominantly unilateral. Read More

Med Sci Monit 2019 Feb 2;25:946-951. Epub 2019 Feb 2.

Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China (mainland).

BACKGROUND The aim of this study was to investigate the correlations of calcium voltage-gated channel subunit alpha1 A (CACNA1A) gene polymorphisms with benign paroxysmal positional vertigo (BPPV). MATERIAL AND METHODS A total of 120 BPPV patients and 60 healthy controls were enrolled according to the diagnostic criteria in the Guideline of Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo (2017). Clinical and biochemical data were collected, the rs2074880 (T/G) polymorphisms in the CACNA1A gene were detected using TaqMan-MGB probe method, and the correlations of BPPV with predisposing factors were analyzed through logistic analysis. Read More

J Am Med Dir Assoc 2019 Feb;20(2):224.e1-224.e23

School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.

Objective: This systematic review aimed to methodically review the available evidence on poor treatment outcomes after repositioning maneuver treatments in adults with BPPV and whether there are differences in the outcomes for older and younger adults.

Data Sources: Embase, CINAHL, Scopus, PsycINFO (Ovid), Central Register of Controlled Trials (CENTRAL), and PubMed.

Review Methods: Studies were included if they were prospective experimental or observational studies with a minimal follow-up of 1 month; the subjects were at least 18 years old, had BPPV, and were treated with repositioning maneuvers. Read More

Stroke Vasc Neurol 2018 Dec 23;3(4):190-196. Epub 2018 Jun 23.

Department of Neurology, University of Illinois College of Medicine, Peoria, Illinois, USA.

Following the initial description of HINTS to diagnose acute vestibular syndrome (AVS) in 2009, there has been significant interest in the systematic evaluation of HINTs to diagnose stroke and other less common central causes of AVS. This trend increased with availability of the video head impulse test (video-HIT). This article reviews the original papers and discusses the main publications from 2009 to 2017. Read More

Hautarzt 2019 Jan 9. Epub 2019 Jan 9.

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Deutschland.

Background: Extracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.

Methods: Treatment protocols of 2038 ECP procedures in 52 patients (CTCL, n = 29; GvHD, n = 15; other, n = 8) were evaluated. Read More

BMJ Case Rep 2019 Jan 7;12(1). Epub 2019 Jan 7.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

A 26-year-old patient of limited cutaneous sclerosis presented to us with insidious-onset posterior fossa symptoms of headache, vomiting, vertigo and gait imbalance, progressing over a period of 3 weeks. A diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids was made by combining the clinical features with radiological evidence showing punctate infiltration of the pons, brainstem and cerebellum. Relevant differentials in the form of neurosarcoid, infections, central nervous system (CNS) lymphoma and Neuro-Behcet's disease were ruled out by history and investigations. Read More

Mult Scler Relat Disord 2018 Dec 24;28:159-164. Epub 2018 Dec 24.

Wayne State School of Medicine, Department of Neurology, Detroit, MI, USA.

Background: Vertigo is a common symptom of multiple sclerosis (MS) that can be caused by a central or peripheral involvement of the vestibular pathways. Magnetic Resonance Imaging (MRI) is commonly used to evaluate progression of MS but is not sensitive enough to detect small lesions. Vestibular evoked myogenic potentials (VEMPs) are commonly used to evaluate function of vestibular-cochlear pathways. Read More

Cochrane Database Syst Rev 2018 12 31;12:CD012173. Epub 2018 Dec 31.

Ear Institute, Faculty of Brain Sciences, University College London, London, UK.

Background: Ménière's disease or syndrome is a chronic inner ear disorder that results in sporadic attacks of vertigo, sensorineural hearing loss, aural fullness and tinnitus.There is no definitive treatment for Ménière's disease and treatment options range from dietary modification through medication to surgery.Modification of diet, including restriction of salt, caffeine and alcohol intake, is a management option that is widely recommended to patients with Ménière's as a first-line treatment. Read More

Ann Agric Environ Med 2018 Dec 14;25(4):665-668. Epub 2018 Feb 14.

Balance Disorder Unit, Otolaryngology Department, Medical University of Lodz, Norbert Barlicki Memorial University Hospital No. 1, Poland.

Introduction: In the literature there are some discrepancies concerning the occurrence of vertigo and disequilibrium, as well as the type of vestibular dysfunction in patients after mild traumatic brain injury (MTBI).

Objective: The aim of the study was to assess the type of vestibular system dysfunction in MTBI patients after injury at baseline and 6-month follow-up.

Material And Methods: From a group of 188 patients with vertigo/dizziness and balance instability after MTBI, prospective analysis in 50 patients with abnormal videonystagmography (VNG) were conducted. Read More

Curr Opin Neurol 2019 Feb;32(1):174-180

German Center for Vertigo and Balance Disorders.

Purpose Of Review: To review recent work on clinical and imaging aspects of vestibular neuritis (or acute vestibular syndrome), in particular with a view to identifying factors predicting long-term clinical outcome.

Recent Findings: Evidence for a role of inflammation in the vestibular nerve, and the presence of Gadolinium enhancement acutely in vestibular neuritis, is accruing. Visual dependence, anxiety and somatization traits predict the development of chronic dizziness after acute vestibular neuritis. Read More

Curr Opin Neurol 2019 Feb;32(1):165-173

Otology & Neurotology Group CTS495, Department of Genomic Medicine- Centro de Genómica e Investigación Oncológica - Pfizer/Universidad de Granada/ Junta de Andalucía (Genyo), PTS.

Purpose Of Review: To provide an update on the most frequent peripheral vestibular disorders.

Recent Findings: The on-going classification of vestibular disorders by the Bárány Society represents major progress. The diagnosis of bilateral vestibulopathy (BVP) requires quantitative testing of vestibular function. Read More

Cerebellum 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Ludwig-Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany.

The differential diagnosis of vertigo or dizziness as a result of cerebellar disorders can be difficult as many patients with a cerebellar pathology do not present with the full spectrum of cerebellar signs. The main goal of this study was to describe the typical clinical features of these patients with vertigo or dizziness of a cerebellar origin. We reviewed the medical records of 5400 patients with vertigo and dizziness from our tertiary outpatient clinic for vertigo and balance disorders. Read More

Otol Neurotol 2019 Feb;40(2):e170-e172

Department of Neurology.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1426-1428

Department of Otolaryngology Head and Neck Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University.

To analyze the characteristics of patients with benign paroxysmal positional vertigo which were spontaneously cured. A total of 1 257 patients with chief complaint of positional vertigo were included and analyzed retrospectively, in which 921 cases were diagnosed as BPPV with the diagnosis standard of Guiyang meeting, and the other 336 cases were negative in the positional test diagnosed as BPPV-spontaneously cured. The age，gender and history course of the two groups were analyzed respectively. Read More

Medicina (B Aires) 2018 ;78(6):410-416

Servicio de Otorrinolaringología, Hospital Británico de Buenos Aires, Argentina.

Vertigo is defined as an abnormal sensation of body motion or of its surrounding objects. It is a common chief complaint in emergency departments comprising 2 to 3% of these consultations worldwide. Vertigo is classified as peripheral or central, according to its origin, and can also be occasionally mixed, the most common cause of peripheral involvement being benign paroxysmal positional vertigo. Read More

Cochrane Database Syst Rev 2018 Nov 26;11:CD012557. Epub 2018 Nov 26.

Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo, 112, Rome, Italy, 00154.

Background: Alcohol use disorder (AUD) and alcohol-related impairments belong to the most widespread psychiatric disorders leading to specific psychophysical, affective and cognitive symptoms and consequences for psychosocial well-being and health. Alcohol consumption is increasingly becoming a problem in many developing regions and AUD prevalence is estimated at 4.1% worldwide, with highest prevalence in European countries (7. Read More

Curr Probl Cancer 2018 Nov 16. Epub 2018 Nov 16.

Neuro-oncology Unit, Research Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.

Background And Purpose: Cancer and stroke are the second and third causes of death worldwide; brain metastases (BM) occur in one third of patients with cancer, any neurologic deficit in these population always prompts the clinician to discard metastases for their presence carries a bad outcome. Both might share clinical presentation and differences in their outcome are not entirely known. The aim was to compare risk factors, clinical presentation, and outcome of cancer patients with BM vs stroke. Read More

Handb Clin Neurol 2018 ;158:135-144

Baylor Institute for Rehabilitation, Frisco, TX, United States.

The assessment and treatment of sport-related concussion (SRC) often requires a multifaceted approach. Vestibular dysfunction represents an important profile of symptoms and pathology following SRC, with high prevalence and association with prolonged recovery. Signs and symptoms of vestibular dysfunction may include dizziness, vertigo, disequilibrium, nausea, and visual impairment. Read More

Handb Clin Neurol 2018 ;159:385-401

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, Australia; Neurology Department, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Disorders of the inner-ear balance organs can be grouped by their manner of presentation into acute, episodic, or chronic vestibular syndromes. A sudden unilateral vestibular injury produces severe vertigo, nausea, and imbalance lasting days, known as the acute vestibular syndrome (AVS). A bedside head impulse and oculomotor examination helps separate vestibular neuritis, the more common and innocuous cause of AVS, from stroke. Read More

Curr Opin Neurol 2019 Feb;32(1):137-144

Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania.

Purpose Of Review: Rehabilitation for persons with vertigo and balance disorders is becoming commonplace and the literature is expanding rapidly. The present review highlights recent findings of both peripheral and central vestibular disorders and provides insight into evidence related to new rehabilitative interventions. Risk factors will be reviewed to create a better understanding of patient and clinical characteristics that may effect recovery among persons with vestibular disorders. Read More

Curr Opin Neurol 2019 Feb;32(1):154-164

German Center for Vertigo and Balance Disorders.

Purpose Of Review: To apply the concept of nonreflexive sensorimotor and cognitive vestibular functions and disturbances to the current view of separate right and left thalamocortical systems.

Recent Findings: The neuronal modules for sensorimotor and cognitive functions are organized in so-called provincial hubs with intracommunity connections that interact task-dependently via connector hubs. Thalamic subnuclei may serve not only as provincial hubs but also in higher order nuclei as connector hubs. Read More

J Stroke Cerebrovasc Dis 2019 Feb 9;28(2):412-417. Epub 2018 Nov 9.

History of Medicine, School of Medicine, University of Crete, Heraklion, Greece. Electronic address:

Background: The ancient Greek term "apoplexy" as is repeatedly mentioned by the Hippocratic School of Medicine, included a cluster of diseases, mainly those concerning the central nervous system. The term was wrongfully infiltrated in Western European medicine as synonymous to what is called today a "stroke" of the brain.

Objective: While in "Corpus Hippocraticum" the definition of the stroke was rather ambiguous; our study aims to unveil those fragments referring to it, in order to compose the Hippocratic theory of what it stood for "Acute Brain Suffering" (Greek: Οξείες Οδύνες του Εγκεφάλου) during the Classical era of ancient Greece. Read More

J Neurol 2019 Jan 30;266(1):247-249. Epub 2018 Oct 30.

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, Australia.

Epilepsia 2018 Dec 28;59(12):2194-2205. Epub 2018 Oct 28.

Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany.

Objective: In patients with epilepsy, psychiatric comorbidities can significantly affect the disease course and quality of life. Detecting and recognizing these comorbidities is central in determining an optimal treatment plan. One promising tool in detecting biomarkers for psychiatric comorbidities in epilepsy is positron emission tomography (PET). Read More

Neuropharmacology 2019 01 24;144:133-142. Epub 2018 Oct 24.

Aix Marseille Université-CNRS, Laboratory of Sensory and Cognitive Neuroscience, LNSC UMR 7260. Team Pathophysiology and Therapy of Vestibular Disorders, Marseille, France; Centre Saint-Charles, Case B; 3 Place Victor Hugo 13331 Marseille cedex 03, France.

Sudden and complete unilateral loss of peripheral vestibular inputs evokes characteristic vestibular syndrome comprised of posturo-locomotor, oculomotor, vegetative and cognitive symptoms. Subsequently to the vestibular insult, a neurophysiological process called central vestibular compensation promotes the progressive restoration of the posture and balance. The modulation of the excitability of vestibular secondary neurons has been demonstrated to be a key process of this mechanism. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(6. Vyp. 2):46-49

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Acute vestibular disorder is a frequent cause of urgent hospitalization in elderly patients. A CNS vascular disorder is often thought to be a cause of vertigo and a patient is diagnosed with stroke or transitory ischemic attack (TIA) or vertebral-basilar insufficiency. Despite the higher risk of cerebrovascular disease in the elderly, stroke and TIA are not the only cause of acute vestibular disorder. Read More

Neuroimage Clin 2018 9;20:1010-1017. Epub 2018 Oct 9.

Neuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UK. Electronic address:

Vestibular neuritis (VN) is characterised by acute vertigo due to a sudden loss of unilateral vestibular function. A considerable proportion of VN patients proceed to develop chronic symptoms of dizziness, including visually induced dizziness, specifically during head turns. Here we investigated whether the development of such poor clinical outcomes following VN, is associated with abnormal visuo-vestibular cortical processing. Read More

Clin Nucl Med 2018 Dec;43(12):925-929

Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.

Dural amyloidoma is an unusual presentation of central nervous system amyloidosis. A 49-year-old woman presented with 1-month history of repeated episodes of vertigo. Precontrast MRI showed dural thickening over right frontal convexity with signal intensity similar to white matter. Read More

Niger J Clin Pract 2018 Oct;21(10):1271-1277

Department of Clinic Biochemistry, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey.

Aim: Central sensitization-related neuroaudiological symptoms are frequently seen in patients with fibromyalgia syndrome (FMS). This study aimed to evaluate the audiological signs and symptoms in patients with FMS and explore their relationship with oxidative stress markers.

Methods: This prospective controlled cross-sectional study compared the serum myeloperoxidase, superoxide dismutase, glutathione peroxidase (GPx), nitric oxide (NO), and malondialdehyde (MDA) concentrations in 44 patients with FMS diagnosed according to the 2010 American College of Rheumatology criteria and 44 healthy volunteers. Read More

Otol Neurotol 2019 Jan;40(1):88-95

Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, University Medical Centre Mannheim, University of Heidelberg, Heidelberg.

Background: Dizziness is a common complaint in medicine. Nevertheless, there is a lack of valid data concerning the age and gender distribution of dizziness disorders within a larger population. Therefore, the aim of the present study is to undertake a representative epidemiological survey that examines all age groups of an entire population and describes the age and gender distribution of the most common peripheral vestibular disorders. Read More

Medicine (Baltimore) 2018 Sep;97(39):e12363

Department of Neurology, Zhejiang Provincial People's Hospital.

This study aimed to observe and analyze the effects and outcomes of patients with apogeotropic direction-changing positional nystagmus (apo-DCPN) who received Gufoni maneuver.A total of 91 patients with positional vertigo admitted to the specialized dizziness clinic in Zhejiang Provincial People's Hospital from February 2014 to August 2017 were included. The immediate treatment responses to the Gufoni maneuver were observed and recorded. Read More

Immunol Res 2018 Oct 1. Epub 2018 Oct 1.

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.

The role of the immune system in mediating cochleovestibular pathologies has received increasing attention in recent years. Autoimmune vertigo may be an invalidating condition and may worsen the quality of life of affected patients, especially in the cases of delayed diagnosis. Since the etiopathogenesis is still not clear, also the treatment is not yet completely delineated. Read More

BMC Infect Dis 2018 Sep 18;18(1):470. Epub 2018 Sep 18.

Centro de Ciências da Saúde, Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Faria S/N, Petrópolis, Natal, Rio Grande do Norte, Brazil.

Background: Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Read More

Mayo Clin Proc Innov Qual Outcomes 2018 Sep 4;2(3):303-308. Epub 2018 Jul 4.

Department of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL.

Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by infiltration of organs by CD68 and CD1a lipid-laden histiocytes, including the central nervous system in more than a third of patients. Molecular analysis of ECD samples has demonstrated the prevalence of V600E mutations as high as 54%. Recently, vemurafenib became the only Food and Drug Administration-approved treatment for patients with ECD who carry the V600E mutation. Read More

Indian J Otolaryngol Head Neck Surg 2018 Sep 13;70(3):428-433. Epub 2018 Jul 13.

2Department of ENT, MGM Medical College and MY Hospital, Indore, M.P. India.

Elderly population is frequently affected by vertigo which affects their mobility and makes them vulnerable to fall and other morbidities. Often these patient visit neurologist and are often subjected to CT scan, MRI brain etc. to rule out a central cause of vertigo; whereas majority of these patients suffer from vestibular cause of vertigo. Read More

Arch Rheumatol 2018 Jun 16;33(2):221-224. Epub 2017 Oct 16.

Department of Rheumatology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey.

In this article, we describe a case of neuro-Behçet's disease presenting with unilateral ptosis and facial paresis due to an intracranial mass lesion. A 25-year-old male patient with a history of Behçet's disease presented with headache, vertigo, double vision, ptosis in his right eyelid and slurred speech. Cranial magnetic resonance imaging scan revealed a right-sided capsulothalamic lesion, which was extending to the right cerebral pedicle, pons and superior cerebellar pedicle. Read More

Audiol Neurootol 2018 11;23(2):122-125. Epub 2018 Sep 11.

Hatay Mustafa Kemal University Medicine, Faculty Ear-Nose-Throat Department, Hatay, Turkey.

Introduction: Sickle cell anemia is a disease characterized by a wide vaso-occlusive incident from micro-vascular incident to muscularactivity. The cochlear function can also get affected by this vaso-occlusion.

Objective: It is aimed at determining what kind of effects sickle cell anemia has on hearing and balance system. Read More

J Otolaryngol Head Neck Surg 2018 Sep 10;47(1):54. Epub 2018 Sep 10.

Department of Otolaryngology- Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada.

Background: Dizziness is a common presenting symptom in the emergency department (ED). The HINTS exam, a battery of bedside clinical tests, has been shown to have greater sensitivity than neuroimaging in ruling out stroke in patients presenting with acute vertigo. The present study sought to assess practice patterns in the assessment of patients in the ED with peripherally-originating vertigo with respect to utilization of HINTS and neuroimaging. Read More

Physiother Theory Pract 2018 Sep 10:1-12. Epub 2018 Sep 10.

c Department of Physical Therapy , Angelo State University, Texas Tech University System , San Angelo , TX , USA.

Purpose: This case report presents evidence-based physical therapy assessments and interventions for a patient with unilateral vestibular hypofunction (UVH). UVH is the result of peripheral vestibular dysfunction in the inner ear.

Case Description: The patient was a 48-year-old male with symptoms of dizziness, cephalalgia, and cervicalgia. Read More

J Neurol 2018 Sep 5. Epub 2018 Sep 5.

Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Discriminating strokes in patients with acute dizziness/vertigo is challenging especially when other symptoms and signs of central nervous involvements are not evident. Despite the developments in imaging technology over the decades, a significant proportion of acute strokes may escape detection on imaging especially during the acute phase or when the lesions are small. Thus, small strokes causing isolated dizziness/vertigo would have a higher chance of misdiagnosis in the emergency department. Read More

Curr Neuropharmacol 2019 ;17(1):7-13

Department of Neurology, German Center for Vertigo and Balance Disorders, and Institute for Clinical Neurosciences, University Hospital Munich, Campus Grosshadern, Munich, Germany.

Cerebellar ataxia is a frequent and often disabling syndrome severely impairing motor functioning and quality of life. Patients suffer from reduced mobility, and restricted autonomy, experiencing an even lower quality of life than, e.g. Read More

Nervenarzt 2018 Oct;89(10):1106-1114

Neurologische Klinik und Poliklinik, Universitätsklinikum Ludwig-Maximilians-Universität München, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland.

Vertigo and dizziness are frequent chief complaints in clinical practice. Symptoms may originate from otological, neurological, medical and psychiatric etiologies, which poses an interdisciplinary challenge. Systematic analysis of case history and clinical examination generally allow classification into peripheral-, central- or non-vestibular disorders. Read More

Cerebellum 2018 Aug 22. Epub 2018 Aug 22.

Department of Neurology, Cleveland VA Medical Center, University Hospitals, Cleveland, OH, 44022, USA.

An autoimmune disorder of the central nervous system, stiff person syndrome, frequently presents with increased titers of 65KD anti-glutamic acid decarboxylase (anti-GAD) antibodies. The clinical phenomenology of this syndrome includes stiffness, ataxia, vertigo due to horizontal gaze-evoked and downbeat vertical nystagmus, and dysmetria of saccades and reaching movements. Here, we describe a novel phenomenology of syndrome of anti-GAD antibody, non-position-dependent upbeat nystagmus and superimposed horizontal gaze-evoked nystagmus. Read More

Mult Scler Relat Disord 2018 Oct 8;25:232-240. Epub 2018 Aug 8.

Medicine (Neurology), University of British Columbia and The Djavad Mowafaghian Centre for Brain Health, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

Background: Previous studies suggest the existence of a prodromal period in multiple sclerosis, but little is known about the phenotypic characteristics. This study aims to characterize the multiple sclerosis (MS) prodrome using data mining analytics in the healthcare setting.

Methods: We identified people with MS and matched general population controls using health administrative data in two Canadian provinces (British Columbia and Saskatchewan). Read More

Ideggyogy Sz 2018 Jul;71(7-08):221-235

Petz Aladár Megyei Oktató Kórház, Fül-Orr-Gégészeti és Fej-, Nyaksebészeti Osztály, Gyôr.

Dizziness is one of the most common causes of medical visits. Management of the dizzy patient may be challenging both for the general practitioner, in emergency departments, and special clinics, as behind a seemingly homogeneous clinical presentation several very different etiologies may occur. Research of the last two century enriched our knowledge about physiology and pathophysiology of the vestibular system. Read More

Orphanet J Rare Dis 2018 Aug 15;13(1):137. Epub 2018 Aug 15.

Department of Otorhinolaryngology, Head and Neck Surgery "Otto Körner", University Medical Center Rostock, Doberaner Straße 137-139, D-18057, Rostock, Germany.

Background: Fabry Disease (FD) is an X-linked hereditary lysosomal storage disorder which leads to a multisystemic intralysosomal accumulation of globotriaosylceramid (Gb3). Besides prominent renal and cardiac organ involvement, patients commonly complain about vestibulocochlear symptoms like high-frequency hearing loss, tinnitus and vertigo. However, comprehensive data especially on vertigo remain scarce. Read More

Otol Neurotol 2018 Oct;39(9):1163-1171

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objective: To identify novel language usage by expert providers predictive of specific vestibular conditions.

Study Design: Retrospective chart review and natural language processing. Level IV. Read More