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Electrical Thalamic Stimulation in the Anterior Part of the Ventral Posterolateral Nucleus for the Treatment of Patients With Central Poststroke Pain.

Neuromodulation 2020 Jul 3. Epub 2020 Jul 3.

Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Objectives: The effects of thalamic stimulation of the anterior part of the ventral posterolateral nucleus (VPLa) for central poststroke pain (CPSP) and the pain-related electrophysiological characteristics of this structure were investigated.

Materials And Methods: Nine patients with CPSP manifesting as hemibody pain were enrolled. Stereotactic thalamic VPLa stimulation was implemented, and intraoperative electrophysiological studies on hyperactive and unstable discharges (HUDs) and responses to sensory and electrical stimulation were performed in the sensory thalamus. Read More

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http://dx.doi.org/10.1111/ner.13215DOI Listing

Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3).

FEBS Lett 2020 Jul 3. Epub 2020 Jul 3.

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolytic pathway, and it plays an essential role in angiogenesis. 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) is frequently used as a glycolysis inhibitor and is thought to inhibit PFKFB3. However, this latter effect of 3PO has never been investigated in detail and was the aim of the present study. Read More

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http://dx.doi.org/10.1002/1873-3468.13878DOI Listing

In silico feasibility assessment of extracorporeal delivery of low-intensity pulsed ultrasound to intervertebral discs within the lumbar spine.

Phys Med Biol 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiation Oncology, University of California San Francisco, San Francisco, California, UNITED STATES.

Low intensity pulsed ultrasound (LIPUS) may have utility for noninvasive treatment of discogenic lower back pain through stimulating, remodeling and accelerating healing of injured or degenerated intervertebral disc (IVD) tissues. This study investigates the feasibility of delivering LIPUS to lumbar IVDs between L2 and S1 spine vertebra using a planar extracorporeal phased array (8 x 8 cm, 1024 elements, 500 kHz). Three 3D anatomical models with heterogenous tissues were generated from patient CT image sets and used in the simulation-based analysis. Read More

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http://dx.doi.org/10.1088/1361-6560/aba28dDOI Listing

Comparison of endoscopic third ventriculostomy with or without choroid plexus cauterization in pediatric hydrocephalus: a systematic review and meta-analysis.

J Neurosurg Pediatr 2020 Jul 3:1-8. Epub 2020 Jul 3.

3Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Objective: Pediatric hydrocephalus is a significant contributor to infant morbidity and mortality, particularly in developing countries. The mainstay of treatment has long been shunt placement for CSF diversion, but recent years have seen the rise of alternative procedures such as endoscopic third ventriculostomy (ETV), which provides similar efficacy in selected patients. The addition of choroid plexus cauterization (CPC) to ETV has been proposed to increase efficacy, but the evidence of its utility is limited. Read More

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http://dx.doi.org/10.3171/2020.4.PEDS19720DOI Listing

Trends and characteristics of infection-related hospital admissions in multiple sclerosis patients in Southwest Finland in 2009-2018.

Mult Scler Relat Disord 2020 Jun 23;44:102328. Epub 2020 Jun 23.

Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland; Department of Clinical Neurosciences, University of Turku, Turku, Finland.

Background: Multiple sclerosis (MS) patients are at increased risk for infections. The aim of this study was to investigate the trends in hospital admissions of patients with MS and to identify the factors predisposing to infection-related admissions.

Methods: Hospital admissions with MS as a primary or an auxiliary diagnosis in the hospital district of Southwest Finland in 2009-2018 were searched and MS patients with infection admissions compared with other MS patients in the hospital district. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102328DOI Listing

Cerebral hemodynamics in patients with multiple sclerosis.

Mult Scler Relat Disord 2020 Jun 17;44:102309. Epub 2020 Jun 17.

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Via Conca 71, 60020 Ancona, Italy.

Background And Purpose: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Although the currently predominant view is that of an autoimmune inflammatory condition, changes in brain vasculature can occur and contribute to pathophysiology. The aim of this study was to evaluate cerebral hemodynamics in patients with MS and explore its relationship with disease status. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102309DOI Listing

Development and validation of the VISAGE AmpliSeq basic tool to predict appearance and ancestry from DNA.

Forensic Sci Int Genet 2020 Jun 20;48:102336. Epub 2020 Jun 20.

Institute of Legal Medicine, Medical University of Innsbruck, Innsbruck, Austria; Forensic Science Program, The Pennsylvania State University, University Park, PA, USA. Electronic address:

Forensic DNA phenotyping is gaining interest as the number of applications increases within the forensic genetics community. The possibility of providing investigative leads in addition to conventional DNA profiling for human identification provides new insights into otherwise "cold" police investigations. The ability of reporting on the bio-geographical ancestry (BGA), appearance characteristics and age based on DNA obtained from a crime scene sample of an unknown donor makes the exploration of such markers and the development of new methods meaningful for criminal investigations. Read More

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http://dx.doi.org/10.1016/j.fsigen.2020.102336DOI Listing

Detection of adulteration in pure honey utilizing Ag-graphene oxide coated fiber optic SPR probes.

Food Chem 2020 Jun 23;332:127346. Epub 2020 Jun 23.

Department of Physics, Central University of Rajasthan, NH-8 Bandarsindri, Ajmer 305817, Rajasthan, India. Electronic address:

Fiber optic surface plasmon resonance (SPR) sensor utilizing silver (Ag) and Ag-graphene oxide (GO) is designed and developed for the detection of adulteration of glucose and fructose in pure honey. The concentration range of the two adulterants in pure honey is varied from 4% to 20% with a step change of 4%. The experiments were performed with two different fiber optic probes viz. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127346DOI Listing

Inhibitory receptor agonists: the future of autoimmune disease therapeutics?

Curr Opin Immunol 2020 Jun 30;67:1-9. Epub 2020 Jun 30.

Department of Immunology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA. Electronic address:

Central and peripheral tolerance both contribute to protection against autoimmunity. The pathogenesis of autoimmunity, however, can result from critical deficits or limitations in peripheral and/or central tolerance mechanisms, presenting an opportunity for therapeutic intervention. Recent advances highlight the substantial impact of inhibitory receptors (IRs), which mediate peripheral tolerance, in autoimmunity. Read More

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http://dx.doi.org/10.1016/j.coi.2020.06.001DOI Listing

Fire's impact on threat detection and risk perception among vervet monkeys: Implications for hominin evolution.

J Hum Evol 2020 Jun 30;145:102836. Epub 2020 Jun 30.

Department of Anthropology, University of Utah, 260 S. Central Campus Drive, Rm 4625 Salt Lake City, UT 84112, USA.

The spatial behavior of primates is shaped by many factors including predation risk, the distribution of food sources, and access to water. In fire-prone settings, burning is a catalyst of change, altering the distribution of both plants and animals. Recent research has shown that primates alter their behavior in response to this change. Read More

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http://dx.doi.org/10.1016/j.jhevol.2020.102836DOI Listing

Safety and efficacy of T-DM1 in patients with advanced HER2-positive breast cancer The Royal Marsden experience.

Cancer Treat Res Commun 2020 Jun 27;24:100188. Epub 2020 Jun 27.

Medical Oncology, Royal Marsden Hospital, Royal Marsden Hospital, Downs Road, Sutton SM25PT, United Kingdom. Electronic address:

Background: Ado-trastuzumab emtansine (T-DM1) is standard of care for patients with advanced HER2+ breast cancer who relapse within 6 months of adjuvant trastuzumab or progress on first-line anti-HER2 therapy. We evaluated its safety and efficacy in our real-world population.

Methods: We identified patients on T-DM1 from 01/01/2014 to 12/03/2018 from our electronic records. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100188DOI Listing

A prospective study of epidemiology of Taenia saginata taeniasis with special emphasis on its infection determinants in Kashmiri population-India.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Department of Zoology, Islamia College of Science & Commerce (UGC autonomous college with potential for excellence), Hawal, 190 002, Srinagar, J&K, India.

Background: Taeniasis caused by two major Taenia species, T. solium and T. saginata is a food borne zoonotic disease of man worldwide. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.088DOI Listing

Gestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: cross-sectional study.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil; Institute of Health Sciences, Immunology Laboratory Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address:

Objectives: The goal of this study was to describe and assess demographic and clinical parameters of women who had infants with stigmata of Congenital Zika Syndrome (CZS) versus those who had normal appearing infants at birth. Providing further details on the clinical caveats of neonatal ZIKV infection.

Methodology: This cross-sectional study was performed in the state of Mato Grosso do Sul, Central-West region of Brazil and included 117 mothers-infant pairs who were interviewed (all mothers had laboratory confirmation by qRT-PCR of ZIKV infection during pregnancy) and 120 gestational outcomes. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.084DOI Listing

Taking advantage of cellular uptake of ferritin nanocages for targeted drug delivery.

J Control Release 2020 Jun 30. Epub 2020 Jun 30.

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic. Electronic address:

The search for ideal nanocarrier, which could be rapidly translated to clinical practice, isstill ongoing over the past few decades. However, many reviews are focused onimportant properties of ideal nanocarrier, including long circulation, high internalization efficiency ofadrug, surface charge of nanocarrier or the ability to encapsulate high amount of a drug. Indeed, theability to encapsulate wide variety of drugs, noimmunogenicity, biodegradability ornanocarrier monodispersity are very important aspects, therefore they are discussed in this review. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.026DOI Listing

Common and rare susceptibility genetic variants predisposing to Brugada Syndrome in Thailand.

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Pacific Rim Electrophysiology Research Institute, Bumrungrad Hospital, Bangkok, Thailand.

Background: Mutations in SCN5A are rarely found in Thai patients with Brugada syndrome (BrS). Recent evidence suggested that common genetic variation may underlie BrS in a complex inheritance model.

Objective: To find common and rare/low frequency genetic variants predisposing to BrS in Thailand. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.027DOI Listing

Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea is Safe and Effective in Patients with Concomitant Cardiac Devices.

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Central sleep apnea is common in heart failure patients. Transvenous phrenic nerve stimulation (TPNS) requires placing a lead to stimulate the phrenic nerve and activate the diaphragm. Data are lacking concerning the safety and efficacy of TPNS in patients with concomitant cardiovascular implantable electronic devices (CIEDs). Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.023DOI Listing

Regional balance between glutamate+glutamine and GABA+ in the resting human brain.

Neuroimage 2020 Jun 30:117112. Epub 2020 Jun 30.

Department of Psychology and Brain Sciences, Dartmouth College, Hanover, NH.

Models of healthy brain function and psychiatric conditions assume that excitatory and inhibitory activity are balanced in the human brain at multiple spatial and temporal scales. In human neuroimaging, concentrations of the major excitatory (glutamate) and inhibitory (γ-aminobutyric acid, GABA) neurotransmitters are measured in vivo using magnetic resonance spectroscopy (MRS). However, despite the central importance of E/I balance to theories of brain function, a relationship between regional glutamate and GABA levels in the human brain has not been shown. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117112DOI Listing

Serotonergic psychedelics LSD & psilocybin increase the fractal dimension of cortical brain activity in spatial and temporal domains.

Neuroimage 2020 Jun 30:117049. Epub 2020 Jun 30.

Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, UK; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, UK.

Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers investigating the neural origins of consciousness. Currently, the most compelling theories of how psychedelics exert their effects is by increasing the complexity of brain activity and moving the system towards a critical point between order and disorder, creating more dynamic and complex patterns of neural activity. While the concept of criticality is of central importance to this theory, few of the published studies on psychedelics investigate it directly, testing instead related measures such as algorithmic complexity or Shannon entropy. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117049DOI Listing

Osteochondral repair combining therapeutics implant with Mesenchymal stem cells spheroids.

Nanomedicine 2020 Jun 30:102253. Epub 2020 Jun 30.

INSERM (French Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, 67000, Strasbourg, France; Université de Strasbourg, Faculté de Chirurgie Dentaire, 67000 Strasbourg, France. Electronic address:

Functional articular cartilage regeneration remains challenging, and it is essential to restore focal osteochondral defects and prevent secondary osteoarthritis. Combining autologous stem cells with therapeutic medical device, we developed a bi-compartmented implant that could promote both articular cartilage and subchondral bone regeneration. The first compartment based on therapeutic collagen associated with bone morphogenetic protein 2, provides structural support and promotes subchondral bone regeneration. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102253DOI Listing

Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p.

Acta Biomater 2020 Jun 30. Epub 2020 Jun 30.

Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China. Electronic address:

Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) (MSC-EVs) exhibit protective effects in damaged or diseased tissues. However, the role of EVs secreted by MSC in hypoxia-ischemic (HI) injury in neonatal mice remains unknown. Systemic administration of MSC-EVs attenuated acute brain damage and neuroinflammation, and skewed CD11b/CD45 microglia and CD11b/CD45 brain monocyte/macrophage towards a more anti-inflammatory property as determined at 72 h post-HI. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.037DOI Listing

Diagnosis of Intracranial Primary Central Nervous System Lymphoma Based on Magnetic Resonance Imaging.

Neurosci Lett 2020 Jun 30:135225. Epub 2020 Jun 30.

Department of Radiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Electronic address:

Objective: To analyse the traditional MRI signs, diffusion weighted imaging (DWI), perfusion weighted imaging (PWI), and hydrogen proton magnetic resonance spectroscopy (1H-MRS) of intracranial primary central nervous system lymphoma in immunocompetent people. To explore its diagnostic value.

Methods: The paper retrospectively analysed the MRI signs of 12 patients with primary central nervous system lymphoma confirmed by surgery and pathology. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135225DOI Listing

Astragaloside IV alleviates the brain damage induced by subarachnoid hemorrhage via PI3K/Akt signaling pathway.

Neurosci Lett 2020 Jun 30:135227. Epub 2020 Jun 30.

Department of Brain Emergency, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061000, Hebei, China.

Subarachnoid hemorrhage (SAH) caused brain damage accounts for more than 20% death of patients with cerebrovascular diseases. We aimed to investigate the effects of Astragaloside IV (AS-IV) on SAH-induced brain damage and its underlying mechanism. SAH rat model was established and treated with or without AS-IV. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135227DOI Listing

Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice.

Neurosci Lett 2020 Jun 30:135192. Epub 2020 Jun 30.

Department of Neurology, Zibo Central Hospital, Shandong University, Zibo 255036, China. Electronic address:

Melatonin is a tryptophan metabolite synthesized by the pineal gland. Recent research showed that melatonin has a protective effect in Alzheimer's disease (AD). However, its exact mechanism is still unclear. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135192DOI Listing

The IL-2 - IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor.

Authors:
Jan Damoiseaux

Clin Immunol 2020 Jun 30:108515. Epub 2020 Jun 30.

Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address:

The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108515DOI Listing

Diversity, phylogeny, and historical biogeography of large-eye seabreams (Teleostei: Lethrinidae).

Mol Phylogenet Evol 2020 Jun 30:106902. Epub 2020 Jun 30.

Institut de recherche pour le développement, IRD-UMR 250, 911 Avenue Agropolis, 34394 Montpellier cedex, France. Electronic address:

The large-eye seabreams or Monotaxinae is one of two subfamilies in the Lethrinidae, a family of perch-like coral reef fishes. Despite its widespread occurrence and its commercial interest in the tropical Indo-West Pacific (IWP), this subfamily has traditionally been considered a taxonomically difficult group. Based on 268 samples collected from all 15 known large-eye seabream species throughout their distribution ranges, we investigated the taxonomic diversity and phylogenetic relationships in the subfamily. Read More

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http://dx.doi.org/10.1016/j.ympev.2020.106902DOI Listing

Systemic Corticosteroid Use after Central Serous Chorioretinopathy Diagnosis.

Ophthalmology 2020 Jun 30. Epub 2020 Jun 30.

Byers Eye Institute at Stanford, Palo Alto, CA, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. Electronic address:

Objective: To analyze frequency of systemic corticosteroid prescriptions before and after central serous chorioretinopathy (CSC) diagnosis.

Design: Retrospective claims-based analysis.

Participants: A nationally-representative sample of commercial insurance beneficiaries who received care between 2007-2015. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.06.056DOI Listing

A Non-canonical BRCT-Phosphopeptide Recognition Mechanism Underlies RhoA Activation in Cytokinesis.

Curr Biol 2020 Jun 26. Epub 2020 Jun 26.

Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

Cytokinesis partitions the cell contents to complete mitosis. During cytokinesis, polo-like kinase 1 (PLK1) activates the small GTPase RhoA to assemble a contractile actomyosin ring. PLK1 is proposed to pattern RhoA activation by creating a docking site on the central spindle that concentrates the RhoA guanine nucleotide exchange factor ECT2. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.090DOI Listing

Continent-wide Shifts in Song Dialects of White-Throated Sparrows.

Curr Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Biology, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.

Hypotheses on regional song variation ("dialects") assume that dialects remain stable within regions, are distinct between regions, and persist within populations over extensive periods [1-3]. Theories to explain dialects focus on mechanisms that promote persistence of regional song variants despite gene flow between regions [4-6], such as juveniles settling in non-natal populations retaining only those songs from their repertoires that match neighbors [7, 8]. It would be considered atypical for a novel song variant to invade and replace the established regional variant. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.084DOI Listing

Measurement properties of isokinetic dynamometry for assessment of shoulder muscle strength: a systematic review.

Arch Phys Med Rehabil 2020 Jun 30. Epub 2020 Jun 30.

Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark.

Objective: To investigate the evidence of measurement properties of isokinetic dynamometry (ID) for assessment of shoulder muscle strength in healthy individuals and patients with non-neurological shoulder pathology.

Data Sources: Cochrane Central Register of Controlled Trials (CENTRAL), Pubmed, EMBASE, and PEDro were searched up to February 2020 without restrictions. Reference lists and citations were hand-searched. Read More

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http://dx.doi.org/10.1016/j.apmr.2020.06.005DOI Listing

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?

Dev Cell 2020 Jul 2. Epub 2020 Jul 2.

Harvard T.H. Chan School of Public Health, Department of Molecular Metabolism, Boston, MA, USA. Electronic address:

Aging is associated with a loss of metabolic homeostasis and plasticity, which is causally linked to multiple age-onset pathologies. The majority of the interventions-genetic, dietary, and pharmacological-that have been found to slow aging and protect against age-related disease in various organisms do so by targeting central metabolic pathways. However, targeting metabolic pathways chronically and ubiquitously makes it difficult to define the downstream effects responsible for lifespan extension and often results in negative effects on growth and health, limiting therapeutic potential. Read More

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http://dx.doi.org/10.1016/j.devcel.2020.06.011DOI Listing

Chronic mandibular hypomobility related to a unilateral accessory condyle. A case report.

Cranio 2020 Jul 3:1-7. Epub 2020 Jul 3.

Research Institute Raúl Vicenelli, Faculty of Dentistry, Central University of Venezuela , Caracas, Venezuela.

Background: Chronic mandibular hypomobility is characterized by a long-standing limitation of the mouth opening related to multiple etiologies, including elongation of the coronoid apophysis. Unlike the most frequent pathologies that cause coronoid elongation, such as hyperplasia, osteoma (OM), and osteochondroma (OC), the accessory mandibular condyle (AMC) is a rare entity. : The AMC shows a configuration similar to a normal mandibular condyle with an articular surface covered by fibrocartilage that articulates with the temporal wall of the zygomatic bone, and histologically, does not show neoplastic growth. Read More

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http://dx.doi.org/10.1080/08869634.2020.1788842DOI Listing

species infections in humans: a systematic review.

J Chemother 2020 Jul 3:1-11. Epub 2020 Jul 3.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

species have been recognized to cause infections in immunocompromised individuals. The purpose of this study was to systemically review all published cases of infections in humans and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. We performed a systematic review of PubMed (through 20 Octrober 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of species infections. Read More

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http://dx.doi.org/10.1080/1120009X.2020.1785742DOI Listing

A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review.

Cutan Ocul Toxicol 2020 Jul 3:1-18. Epub 2020 Jul 3.

Department of Ophthalmology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

To evaluate the characteristics of macular retinal and subfoveal choroidal changes in patients already on taxane-based therapy by the help of spectral domain optical coherence tomograpy (SD-OCT) and determine the incidence of taxane- related cystoid macular edema (CME). In this cross-sectional case-control study, 202 patients who received taxane-based therapy due to treatment of various cancer and age and sex-matched 200 healthy control subjects were examined. Only patients who received at least 4 cycles of taxane-based therapy were taken into consideration for the taxane group. Read More

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http://dx.doi.org/10.1080/15569527.2020.1790592DOI Listing

Genetic structure and insecticide resistance characteristics of fall armyworm populations invading China.

Mol Ecol Resour 2020 Jul 3. Epub 2020 Jul 3.

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.

The rapid wide-scale spread of fall armyworm (Spodoptera frugiperda) has caused serious crop losses globally. However, differences in the genetic background of subpopulations and the mechanisms of rapid adaptation behind the invasion are still not well understood. Here we report the assembly of a 390. Read More

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http://dx.doi.org/10.1111/1755-0998.13219DOI Listing

Muxeres en Acción: The Power of Community Cultural Wealth in Latinas Organizing for Health Equity.

Am J Community Psychol 2020 Jul 3. Epub 2020 Jul 3.

University of California Davis, Davis, CA, USA.

Community psychology, despite its commitment to social justice, is prone to engage in deficit-based perspectives that do not appropriately capture the strengths of Latinx communities. Given these limitations, we use a Community Cultural Wealth (CCW) (Yosso, 2005) framework to describe how muxeres, Latina women who identify as promotoras, madres, and mamás, leveraged their political power and culturally informed leadership to improve the health and well-being of their communities. We highlight instances from our fieldwork, witnessing the agency of muxeres en acción for health equity. Read More

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http://dx.doi.org/10.1002/ajcp.12442DOI Listing

[A pedigree of L-2-hydroxyglutaric aciduria including 3 patients caused by homozygous L2HGDH variant].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):799

Department of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.024DOI Listing

[Clinical characteristics and variant analysis of five pedigrees with hereditary spastic paraplegia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jul;37(7):709-712

Department of Central Laboratory, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, China.

Objective: To explore the clinical and genetic characteristics of five pedigrees affected with hereditary spastic paraplegia(HSP).

Methods: Clinical data of the five pedigrees was collected, and high-throughput sequencing was carried out to detect potential variants. Sanger sequencing were used to verify the results. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.07.002DOI Listing

Circadian tau differences and rhythm associations in Delayed Sleep-Wake Phase Disorder and sighted Non-24-Hour Sleep-Wake Rhythm Disorder.

Sleep 2020 Jul 3. Epub 2020 Jul 3.

Adelaide Institute for Sleep Health: A Flinders Centre of Research Excellence, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia.

Study Objectives: We investigated biological and behavioural rhythm period lengths (i.e., taus) of Delayed Sleep-Wake Phase Disorder (DSWPD) and Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD). Read More

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http://dx.doi.org/10.1093/sleep/zsaa132DOI Listing

Network Structure of Physical, Cognitive, and Emotional Symptoms at Preseason Baseline in Student Athletes with Attention-Deficit/ Hyperactivity Disorder.

Arch Clin Neuropsychol 2020 Jun 3. Epub 2020 Jun 3.

Department of Psychology, Harvard University, Cambridge, MA, USA.

Objective: Preexisting attention-deficit/hyperactivity disorder (ADHD) may be a risk factor for worse outcome following sport-related concussion. We used a statistical and psychometric approach known as network analysis to examine the architecture of physical, cognitive, and emotional symptoms at preseason baseline among student athletes with ADHD.

Method: A cohort of 44,527 adolescent student athletes completed baseline preseason testing with ImPACT® between 2009 and 2015. Read More

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http://dx.doi.org/10.1093/arclin/acaa030DOI Listing

A Measles outbreak in the Tel Aviv District, Israel, 2018-2019.

Clin Infect Dis 2020 Jul 3. Epub 2020 Jul 3.

Tel Aviv District Health Office, Ministry of Health, Israel.

During a national measles outbreak in 2018-2019, the Tel Aviv District suffered a major upsurge of cases, with 413 patients reported. Among them, 100 (24%) were under the age of one, 92 (22%) patients were aged 12 months to 4 years, 47 (11%) were 5-18 years, 169 (41%) were aged 19-60 years, 5 (1%) patients were older than 61 years (born before 1957). Among all cases, 230 (56%) were part of the Ultra-Orthodox Jewish community, 55 (13%) were among undocumented African immigrants. Read More

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http://dx.doi.org/10.1093/cid/ciaa931DOI Listing

Magnetic resonance imaging classification of deep pelvic endometriosis: description and impact on surgical management.

Hum Reprod 2020 Jul 3. Epub 2020 Jul 3.

Sorbonne Université, IUC, 75005 Paris, France.

Study Question: Is an MRI classification of deep pelvic endometriosis (DE) able to correctly predict the risk of DE surgery.

Summary Answer: A new radiological classification, that we have called the deep pelvic endometriosis index (dPEI) classification, is accurate and reproducible to assess the extension of the disease in central and lateral compartments and well correlated with operating time, hospital stay duration and the risk of voiding dysfunction.

What Is Known Already: Few imaging classifications are currently available to predict the extent of DE to help preoperative assessment of surgical outcomes and provide the patient with objective information about the risk of surgical complications. Read More

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http://dx.doi.org/10.1093/humrep/deaa103DOI Listing

The Identity of Psychiatry and the Challenge of Mad Activism: Rethinking the Clinical Encounter.

J Med Philos 2020 Jul 3. Epub 2020 Jul 3.

Department of Philosophy, Birbeck College, University of London, London, United Kingdom.

Central to the identity of modern medical specialities, including psychiatry, is the notion of hypostatic abstraction: doctors treat conditions or disorders, which are conceived of as "things" that people "have." Mad activism rejects this notion and hence challenges psychiatry's identity as a medical specialty. This article elaborates the challenge of Mad activism and develops the hypostatic abstraction as applied to medicine. Read More

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http://dx.doi.org/10.1093/jmp/jhaa009DOI Listing

Serum Carboxypeptidase N 1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer.

Anticancer Agents Med Chem 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin. China.

Background: The incidence and mortality of breast cancer are increasing annually. Breast cancer seriously threatens women's health and quality of life. We aimed to measure the clinical value of CPN1, a new serum marker of breast cancer and to evaluate the efficacy of CPN1 in combination with CA15-3. Read More

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http://dx.doi.org/10.2174/1871520620666200703191135DOI Listing

Head-to-head comparison of the diagnostic accuracy of Xpert MTB/RIF and Xpert MTB/RIF Ultra for tuberculosis: a meta-analysis.

Infect Dis (Lond) 2020 Jul 3:1-13. Epub 2020 Jul 3.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

: Tuberculosis (TB) diagnosis has significantly improved since the introduction of the automated molecular test Xpert MTB/RIF (Xpert) and the new version Xpert MTB/RIF Ultra (Ultra) that detect . Due to the rapidly widespread use of Xpert and Ultra, we conducted a meta-analysis to compare the performances of Xpert and Ultra in diagnosing TB and discuss the advantages and limitations of these two tests.: Web of Science, Medline ( PubMed), Embase ( OvidSP), the Cochrane Central Register of Controlled Trials and Google Scholar (up to April 2020) were searched for relevant studies. Read More

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http://dx.doi.org/10.1080/23744235.2020.1788222DOI Listing

Characterization of dendritic cells in human and experimental myocarditis.

ESC Heart Fail 2020 Jul 3. Epub 2020 Jul 3.

Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, Jena, Germany.

Aims: Dendritic cells (DCs) are central mediators of adaptive immunity, and there is growing evidence of their role in myocardial inflammatory disease. We hypothesized that plasmacytoid and myeloid DCs are involved in the mechanisms of myocarditis and analysed these two main subtypes in human myocarditis subjects, as well as in a murine model of experimental autoimmune myocarditis (EAM).

Methods And Results: Circulating DCs were analysed by flow cytometry in patients with acute myocarditis, dilated cardiomyopathy, and controls. Read More

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http://dx.doi.org/10.1002/ehf2.12767DOI Listing

A Nuclear lncRNA Linc00839 as a Myc target to promote breast cancer chemoresistance via PI3K/AKT Signaling Pathway.

Cancer Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Breast Diseases, Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, Jiangsu, China.

Chemoresistance has become a leading cause of mortality in breast cancer patients and is one of the major obstacles for improving the clinical outcome. Long noncoding RNAs play important roles in breast cancer tumorigenesis and chemoresistance. However, the involvement and regulation of lncRNAs in breast cancer chemoresistance are not completely understood. Read More

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http://dx.doi.org/10.1111/cas.14555DOI Listing

Laparoscopic Complete Mesocolic Excision of Left colonic lesion-A video vignette.

Colorectal Dis 2020 Jul 3. Epub 2020 Jul 3.

Colorectal division, GI services, Department of Colorectal surgery, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

Complete mesocolic excision (CME) for colonic lesions was first described by Hohenberger in 2009 adopting principles similar to those of TME along with central vascular ligation and extended lymphadenectomy . The procedure has been demonstrated to have improved oncological outcomes when compared to no CME colectomies in a few studies. Laparoscopy is an acceptable approach and is preferred by many centers due to its associated benefits and similar oncological outcomes. Read More

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http://dx.doi.org/10.1111/codi.15228DOI Listing

10H-3,6-Diazaphenothiazines triggered the mitochondrial-dependent and cell death receptor-dependent apoptosis pathways and further increased the chemosensitivity of MCF-7 breast cancer cells via inhibition of AKT1 pathways.

J Biochem Mol Toxicol 2020 Jul 3:e22544. Epub 2020 Jul 3.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Breast cancer is one of the leading causes of death in cancer categories, followed by lung, colorectal, and ovarian among the female gender across the world. 10H-3,6-diazaphenothiazine (PTZ) is a thiazine derivative compound that exhibits many pharmacological activities. Herein, we proceed to investigate the pharmacological activities of PTZ toward breast cancer MCF-7 cells as a representative in vitro breast cancer cell model. Read More

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http://dx.doi.org/10.1002/jbt.22544DOI Listing

Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.

Alcohol Clin Exp Res 2020 Jul 3. Epub 2020 Jul 3.

From the Columbia University Mailman School of Public Health, New York, New York.

Background: Reductions in World Health Organization (WHO) risk drinking levels have recently been shown to lower the risk of multiple adverse health outcomes, but prior work has not examined reductions in WHO risk drinking levels in relation to cardiovascular disease (CVD), the leading cause of death for men and women in the United States and of global mortality. This study examined associations between reductions in WHO risk drinking levels and subsequent risk for CVD.

Methods: In a US national survey, 1,058 very-high-risk and high-risk drinkers participated in Wave 1 interviews (2001 to 2002) and Wave 2 follow-ups (2004 to 2005). Read More

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http://dx.doi.org/10.1111/acer.14386DOI Listing
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