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Intern Med J 2019 Mar;49(3):396-399

Menzies School of Health Research, Darwin, Northern Territory, Australia.

The burden of skin infections across all age groups in remote Australian Indigenous communities is currently unknown. In a retrospective audit of 439 residents from two remote communities presenting to health clinics, skin conditions were the most common reason for presentation (1603/7392, 22%) and 330/439 (75%) residents presented at least once with a skin infection. Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities and public health campaigns to address this should incorporate all age groups. Read More

Klin Monbl Augenheilkd 2019 Mar 21;236(3):244-252. Epub 2019 Mar 21.

Klinik und Poliklinik für Augenheilkunde, Justus-Liebig-Universität Gießen.

Purpose: Inherited retinal diseases (IRDs) may be caused by variations in genes affecting the connecting cilium of photoreceptor cells and intraflagellar transport, manifested as ciliopathies. is frequently mutated in non-syndromic, but also syndromic IRDs. In preparation for clinical treatment trials, detailed phenotypic work-up including longitudinal follow-up is mandatory. Read More

Klin Monbl Augenheilkd 2019 Mar 21;236(3):253-260. Epub 2019 Mar 21.

Forschungsinstitut für Augenheilkunde, Department für Augenheilkunde, Eberhard Karls Universität Tübingen.

Hereditary retinal degenerative diseases are mostly diseases of the photoreceptors and/or the retinal pigment epithelium, which lead to loss of vision or even complete blindness. To this day, these diseases are mostly untreatable and represent a considerable burden for patients and their relatives. This review article highlights some of the challenges that arise in the development of new therapies for inherited retinal degeneration, in particular the problem of the enormous genetic heterogeneity of these diseases and the question of how new forms of treatment can be made to cross the blood retinal barrier to the nerve cells of the retina. Read More

Eur Neurol 2019 Mar 21;80(5-6):321-332. Epub 2019 Mar 21.

Graduate Program in Neuroscience and Education, University of Macedonia, Thessaloniki,

We present an overview of the International Neurological Congress that was held in Lisbon, Portugal, on September 7-12, 1953, the fifth in the series of meetings that became a tradition and helped to establish Neurology and Neurosurgery as independent medical specialties in the mid-twentieth century. Four main symposia focused on vascular and metabolic diseases of the brain and on the parietal lobe. An additional 345 papers were read on diverse topics. Read More

Nephron 2019 Mar 21:1-10. Epub 2019 Mar 21.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: Cardiac surgery-associated severe acute kidney injury (SAKI) is associated with high mortality and poor quality of life. A prognostic score for SAKI may enable prevention of complications.

Methods: This observational study of 2,552 patients undergoing cardiac surgery from January 2006 to December 2011 in our institution established associations between predictor variables and postoperative SAKI from a cohort of 1,692 patients and developed a clinical score that was assessed in a validation cohort of 860 patients. Read More

Neuroimmunomodulation 2019 Mar 21:1-7. Epub 2019 Mar 21.

Faculdade de Medicina, Universidade Federal de Goiás, Goiânia,

Objective: Multiple sclerosis (MS) is a multifactorial chronic disease that affects the central nervous system (CNS). Toll-like receptors (TLRs) play a central role in cytokine production after pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and contribute to CNS damage in MS patients. Here, we evaluated the effects of interferon (IFN)-β treatment in TLR2 and TLR4-dependent cytokine production and mRNA expression in whole-blood cell cultures from MS patients. Read More

J Neural Eng 2019 Mar 21. Epub 2019 Mar 21.

Electrical and Computer Engineering, University of Central Florida College of Engineering and Computer Science, Orlando, Florida, UNITED STATES.

Objective: The ability to efficiently match the frequency of the brain's response to repetitive visual stimuli in real time is the basis for reliable SSVEP-based Brain-Computer-Interfacing (BCI).

Approach: The detection of different stimuli is posed as a composite hypothesis test, where SSVEPs are assumed to admit a sparse representation in a Ramanujan Periodicity Transform (RPT) dictionary. For the binary case, we develop and analyze the performance of an RPT detector based on a derived generalized likelihood ratio test. Read More

Physiol Meas 2019 Mar 21. Epub 2019 Mar 21.

Electrical Engineering, Eindhoven University of Technology, Flux 7, PO Box 513, Eindhoven, 5600 MB, NETHERLANDS.

Objective: To date, mainly obtrusive methods (e.g., adhesive electrodes in electroencephalography or electrocardiography) are necessary to determine the preterm infant sleep states. Read More

J Hazard Mater 2019 Mar 12;371:694-704. Epub 2019 Mar 12.

Tianjin Key Laboratory of Marine Resources and Chemistry, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300457, China. Electronic address:

A novel ammonium molybdophosphate (AMP)/ polyvinyl alcohol (PVA)/ sodium alginate (SA) composite hydrogel (APS) was prepared for Cs removal and enrichment from radioactive wastewater. Batch experiments with the subject of AMP concentration, pH value, initial Cs concentration, contact time, temperature, competing ions were investigated. The results showed this APS hydrogel with high permeability and stability could effectively adsorb Cs at widely broad pH value range and low Cs concentration within a short time. Read More

Bioresour Technol 2019 Mar 5;282:475-481. Epub 2019 Mar 5.

Department of Agricultural and Biological Engineering, Pennsylvania State University, University Park, PA 16802, USA. Electronic address:

Distillers' dried grains with solubles (DDGS) is the by-product of bioethanol production from starch-rich grains through dry-mill fermentation. In this study, dilute sulfuric acid hydrolysis, aqueous ammonia, and steam explosion as the pre-treatment methods were optimized. The central composite response surface methodology (RSM) design was used for optimization of dilute acid pretreatment, aqueous ammonia pretreatment. Read More

J Environ Manage 2019 Mar 18;239:124-136. Epub 2019 Mar 18.

Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Laboratorio de Biotecnología. Av. Universidad S/N Ciudad Universitaria, San Nicolás de Los Garza, Nuevo León, CP66451, Mexico.

Pesticides currently play a significant role in enhancing agricultural production and offer economic assistance to our farmers. However, their indiscriminate and injudicious application has caused environmental problems and public health concerns. Chlorpyrifos, a pesticide of organophosphate category is used globally as an insecticide, acaricide, and termiticide in households, public health, and agriculture against pests of a wide range. Read More

Sci Total Environ 2019 Feb 22;669:887-892. Epub 2019 Feb 22.

"Constantin Cosma" Radon Laboratory (LiRaCC), Faculty of Environmental Science and Engineering, "Babeş-Bolyai" University, s. no. 30, 400294 Cluj-Napoca, Romania; Department of Medical Physics, Faculty of Medicine, University of Cantabria, c/ Herrera Oria s/n, 39011 Santander, Spain.

In the framework of the last Council Directive 2013/59 (Euratom, 2014) laying down basic safety standards for protection against the dangers arising from exposure to ionizing radiation, the problem of radon was assumed in Romania at national level by responsible authorities through the design and development of a National Radon Action Plan and an adequate legislation (HG nr. 526/2018). In order to identify radon risk areas, however, it is necessary to perform systematic radon measurements in different environmental media (soil gas, water, indoor air) and to map the results. Read More

Sci Total Environ 2019 Mar 11;669:844-855. Epub 2019 Mar 11.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Key Laboratory of Agricultural Remote Sensing, Ministry of Agriculture, Beijing 100081, China. Electronic address:

As an important indicator of soil quality, soil organic matter (SOM) significantly contributes to land productivity and ecosystem health. Accurately mapping SOM at regional scales is of critical importance for sustainable agriculture and soil utilization management and remains a grand challenge. Many studies used soil sampling data and machine learning algorithms to predict SOM at regional scales for a given year, while few studies mapped SOM for multiple years and examined its temporal dynamics. Read More

Neuroimage Clin 2019 Mar 13;22:101752. Epub 2019 Mar 13.

Neuroimaging Center, University Medical Center Groningen, University of Groningen, Neuroimaging Center 3111, Antonius Deusinglaan 2, 9713 AW Groningen, the Netherlands; Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Norway.

To gain insight into possible underlying mechanism(s) of visual hallucinations (VH) in Parkinson's disease (PD), we explored changes in local oscillatory activity in different frequency bands with source-space magnetoencephalography (MEG). Eyes-closed resting-state MEG recordings were obtained from 20 PD patients with hallucinations (Hall+) and 20 PD patients without hallucinations (Hall-), matched for age, gender and disease severity. The Hall+ group was subdivided into 10 patients with VH only (unimodal Hall+) and 10 patients with multimodal hallucinations (multimodal Hall+). Read More

Neuroimage Clin 2019 Mar 12;22:101757. Epub 2019 Mar 12.

Faculty of Medicine of the University of Coimbra, Coimbra, Portugal; Institute for Biomedical Imaging and Life Sciences (CNC.IBILI), University of Coimbra, Coimbra, Portugal; Institute of Nuclear Sciences Applied to Health (ICNAS) and Coimbra Institute for Biomedical Imaging and Life Sciences (CIBIT), University of Coimbra, Coimbra, Portugal. Electronic address:

Diseases involving cilia dysfunction, such as Usher Syndrome (USH), often involve visual and auditory loss. Psychophysical evidence has suggested that this may also hold true for the peripheral olfactory domain. Here we aimed to go a step further by attempting to establish relations between the integrity of cortical structures and olfactory function in this condition. Read More

Redox Biol 2019 Mar 12;24:101166. Epub 2019 Mar 12.

Competence Cluster of Nutrition and Cardiovascular Health (nutriCARD), Jena-Halle-Leipzig, Germany; Department of Nutritional Biochemistry and Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany. Electronic address:

The plant Garcinia kola is used in African ethno-medicine to treat various oxidation- and inflammation-related diseases but its bioactive compounds are not well characterized. Garcinoic acid (GA) is one of the few phytochemicals that have been isolated from Garcinia kola. We investigated the anti-inflammatory potential of the methanol extract of Garcinia kola seeds (NE) and purified GA, as a major phytochemical in these seeds, in lipopolysaccharide (LPS)-activated mouse RAW264. Read More

J Photochem Photobiol B 2019 Feb 23;194:1-5. Epub 2019 Feb 23.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

In the current study, a facile green synthesis of TiO nanoparticles (NPs) utilizing the leaf extract of Lippia citriodora as a stabilizing and reducing agent was reported. The prepared TiO NPs were studied using XRD, UV, HRTEM, FTIR, Raman and EDS analysis. TEM analysis confirmed that the nanoparticles size is in 20-40 nm range. Read More

Atherosclerosis 2019 Feb 25;284:110-120. Epub 2019 Feb 25.

Department of Cardiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, PR China; First clinical medicine college of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, PR China. Electronic address:

Background And Aims: Oxidative stress-induced endothelial dysfunction is considered to exert a vital role in the development of atherosclerotic coronary heart disease (CHD). NRF2 is a key transcriptional factor against oxidative stress through activation of multiple ARE-mediated genes. Z-Lig is derived from the Ligusticum species with antitumor, anti-inflammation and neuroprotection activities. Read More

Circ Genom Precis Med 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Netherlands.

Background: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk.

Methods: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103,357 Europeans with established CHD at baseline from the GENIUS-CHD Consortium (73. Read More

FASEB J 2019 Mar 21:fj201802744R. Epub 2019 Mar 21.

College of Pharmacy, Seoul National University, Seoul, South Korea.

Long noncoding RNA (lncRNA) capable of controlling antioxidative capacity remains to be investigated. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a central molecule for cellular defense that increases antioxidative capacity. We identified a novel lncRNA named Nrf2-activating lncRNA ( Nrf2-lncRNA) transcribed from an upstream region of the microRNA 122 gene ( MIR122). Read More

Rev Med Liege 2019 Mar;74(3):146-151

Service d'Hémato-Oncopédiatrie, CHU Liège, Belgique.

Cancer is the second leading cause of death among children aged 5 to 14, after accidents. We conducted a study on the epidemiology of childhood cancer in the university pediatric oncology department of the CHU-CHR in Liège, Belgium. We studied a cohort of 662 patients between the ages of 0 and 17 whose malignancy diagnosis was made between 1985 and 2016. Read More

Kaohsiung J Med Sci 2019 Mar 21. Epub 2019 Mar 21.

Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

MicroRNA-26a (miR-26a) has been reported to be involved in the tumorigenesis of several tumors, but its biological function and molecular mechanism in multiple myeloma (MM) are still unknown. In this study, we found that overexpression of miR-26a obviously inhibited MM cell growth, and delayed tumor growth in xenografts. Further studies showed that overexpression of miR-26a induced cell cycle arrest at G0/G1 phase in MM cells. Read More

Kaohsiung J Med Sci 2019 Mar 21. Epub 2019 Mar 21.

Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China.

To evaluate the Efficacy and safety of phosphodiesterase type 5 inhibitors as a medical therapy for distal ureteral calculi by means of a systematic review and network meta-analysis (NMA). We searched the Embase, Medline, and the Cochrane Central Register of Controlled Trials for randomised controlled trials (RCTs) published before May, 2017. Stone passage rate as the primary outcome. Read More

Laryngoscope 2019 Mar 21. Epub 2019 Mar 21.

Department of Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.

Objectives/hypothesis: To evaluate the usefulness of fused positron emission tomography (PET)/magnetic resonance (MR) images for surgical planning in patients with oral/oropharyngeal cancer and suspected mandibular invasion.

Study Design: Individual cohort study.

Methods: Eleven of 17 patients with suspected mandibular invasion of squamous cell carcinoma of the lower gingiva, oropharynx, and buccal mucosa who underwent 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) and contrast-enhanced MR imaging (MRI) and had fused PET/MR images were enrolled in this study. Read More

J Forensic Sci 2019 Mar 21. Epub 2019 Mar 21.

Wayne County Medical Examiner's Office, 1300 E. Warren Avenue, Detroit, MI, 48207.

Forensic pathologist use soot and/or stippling surrounding entrance gunshot wounds in categorizing range of fire. If absent, some pathologists suggest utilizing histology when the range is diagnostically critical. This study investigates the concordance of macroscopic and microscopic findings in estimating range of fire by evaluating gunshot entrance and exit wounds made through human tissue analogs at defined distances using two handgun calibers. Read More

Immunology 2019 Mar 21. Epub 2019 Mar 21.

University of California San Diego, Division of Biological Sciences, 9500 Gilman Drive, La Jolla, CA, 92093-0377, United States.

In response to infection, naive CD4 T cells proliferate and differentiate into several possible effector subsets, including conventional T helper effector cells (T 1, T 2, T 17), T regulatory cells (T ), and T follicular helper cells (T ). Once infection is cleared, a small population of long-lived memory cells remain which mediate immune defenses against reinfection. Memory T lymphocytes have classically been categorized into central memory cell (T ) and effector memory cell (T ) subsets, both of which circulate between blood, secondary lymphoid organs, and in some cases non-lymphoid tissues. Read More

J Antimicrob Chemother 2019 Mar 20. Epub 2019 Mar 20.

Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia.

Objectives: To evaluate the performance of the ResistancePlus GC (beta) assay for the simultaneous detection of Neisseria gonorrhoeae and gyrA S91 markers of resistance (S91F) and susceptibility (WT) to ciprofloxacin, from both clinical specimens and isolates.

Methods: Performance was assessed on several sample banks, including N. gonorrhoeae isolates (n = 822), non-gonococcal isolates (n = 110), N. Read More

PLoS One 2019 21;14(3):e0214156. Epub 2019 Mar 21.

Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Huntington's disease (HD) is a devastating monogenic, dominant, hereditary, neurodegenerative disease. HD is caused by the expansion of CAG repeats in exon 1 of the huntingtin (HTT) gene, IT15, resulting in an expanded polyglutamine (polyQ) residue in the N-terminus of the HTT protein. HD is characterized by the accumulation of mutant HTT (mHTT) in neural and somatic cells. Read More

PLoS One 2019 21;14(3):e0207568. Epub 2019 Mar 21.

Institute of Animal Nutrition, Nutrition Diseases and Dietetics, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Fatty acids, as key components of cellular membranes and complex lipids, may play a central role in endocrine signalling and the function of adipose tissue and liver. Thus, the lipid fatty acid composition may play a role in health status in the equine. This study aimed to investigate the fatty acid composition of different tissues and liver lipid classes by comparing Warmblood horses and Shetland ponies under defined conditions. Read More

PLoS One 2019 21;14(3):e0213583. Epub 2019 Mar 21.

Department of Radiology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

Background: The accessibility to radiotherapy facilities may affect the willingness to undergo treatment. We sought to quantify the distance and travel time of Malaysian population to the closest radiotherapy centre and to estimate the megavoltage unit (MV)/million population based on the regions.

Materials & Methods: Data for subdistricts in Malaysia and radiotherapy services were extracted from Department of Statistics Malaysia and Directory of Radiotherapy Centres (DIRAC). Read More

PLoS One 2019 21;14(3):e0213940. Epub 2019 Mar 21.

Division of General Internal Medicine, University Hospitals of Geneva, 4, rue Gabrielle Perret-Gentil, CH, Geneva, Switzerland.

Background: Low-molecular-weight heparin (LMWH) is usually recommended for the treatment of cancer-associated thrombosis (CAT) but this treatment requires burdensome daily injections. We did a systematic review to compare the efficacy and safety of direct oral anticoagulants (DOAC), vitamin K antagonists (VKA) and LMWH in patients with CAT.

Methods: We searched Pubmed, Embase and CENTRAL for randomised controlled trials comparing DOAC, VKA and LMWH in patients with CAT. Read More

PLoS One 2019 21;14(3):e0214072. Epub 2019 Mar 21.

University of Illinois at Chicago, Department of Oral Biology, Chicago, United States of America.

End stage temporomandibular joint osteoarthritis (TMJ-OA) is characterized by fibrillations, fissures, clefts, and erosion of the mandibular condylar cartilage. The goal of this study was to define changes in pericellular and interterritorial delineations of the extracellular matrix (ECM) that occur preceding and concurrent with the development of this end stage degeneration in a murine surgical instability model. Two-photon fluorescence (TPF) and second harmonic generation (SHG) microscopy was used to evaluate TMJ-OA mediated changes in the ECM. Read More

PLoS One 2019 21;14(3):e0213491. Epub 2019 Mar 21.

Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos, Nigeria.

Introduction: Nigeria has one of the highest maternal mortality ratios in the world. The nurses and midwives being the first point of contact play a central role in addressing these problems. This study was conducted to assess the knowledge and utilization of the technologies (misoprostol, anti-shock garment and magnesium sulphate) in the reduction of maternal mortality amongst the Primary Health Care (PHC) nurses and midwives in Lagos State, Nigeria. Read More

PLoS Negl Trop Dis 2019 Mar 21;13(3):e0007119. Epub 2019 Mar 21.

University of Central America, UCA, Managua, Nicaragua.

Retina 2019 Mar 11. Epub 2019 Mar 11.

Department of Ophthalmology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.

Purpose: To compare long-term visual/anatomical outcomes and recurrence rate between oral spironolactone (SPRL) treatment and half-dose photodynamic therapy for nonresolving central serous chorioretinopathy.

Methods: This retrospective, interventional, comparative study included 50 nonresolving central serous chorioretinopathy patients who had exhibited subretinal fluid (SRF) accumulation for >3 months. Of the 50 patients, 26 (26 eyes) received oral SPRL treatment and 24 (24 eyes) received half-dose photodynamic therapy. Read More

Retina 2019 Mar 11. Epub 2019 Mar 11.

Kayseri City Training and Research Hospital, Kocasinan, Kayseri, Turkey.

Purpose: To investigate the effect of age on aflibercept (Eylea) response in macular edema secondary to treatment-naive diabetic eyes.

Methods: Two hundred seventy-three eyes of 273 treatment-naive patients with macular edema secondary to diabetes mellitus were enrolled in this study. The patients in the study were divided into the following 4 groups according to their ages: Group 1 (40-50 years), Group 2 (51-60 years), Group 3 (61-70 years), and Group 4 (>70 years). Read More

Am J Public Health 2019 Mar 21:e1-e6. Epub 2019 Mar 21.

Henry B. Perry is with the Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Jon Rohde is with the James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh.

The Jamkhed Comprehensive Rural Health Project (Jamkhed CRHP) was established in central India in 1970. The Jamkhed CRHP approach, developed by Rajanikant and Mabelle Arole, was instrumental in influencing the concepts and principles embedded in the 1978 Declaration of Alma-Ata. The Jamkhed CRHP pioneered provision of services close to people's homes, use of health teams (including community workers), community engagement, integration of services, and promotion of equity, all key elements of the declaration. Read More

Am J Respir Cell Mol Biol 2019 Mar 21. Epub 2019 Mar 21.

University of North Carolina at Chapel Hill, Marsico Lung Institute/Cystic Fibrosis Center, Chapel Hill, North Carolina, United States ;

Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disease caused by mutations in over 40 different genes. Individuals with PCD caused by mutations in radial spoke head 1 homolog (RSPH1) have been reported to have a milder phenotype compared to other PCD subjects, as evidenced by a lower incidence of neonatal respiratory distress, higher nasal nitric oxide levels, and better lung function. To better understand genotype-phenotype relationships in PCD, we have characterized a mutant mouse model with a deletion of Rsph1. Read More

Rev Esp Enferm Dig 2019 Mar 21;111. Epub 2019 Mar 21.

Department of Gastroenterology, Second Hospital of Tianjin Medical University, Tianjin 300211, China..

Background And Aims: non-alcoholic fatty liver disease (NAFLD) is the most common type of chronic liver injury worldwide. Some studies have shown that thymosin beta4 (Tβ4) is closely related to liver diseases. Nevertheless, only a few published studies have reported the relationship between Tβ4 and NAFLD. Read More

Rev Esp Enferm Dig 2019 Mar 21;111. Epub 2019 Mar 21.

Digestivo, Hospital Universitario Central de Asturias.

We present two cases of immunosuppressed patients diagnosed with acute hepatitis C (AHC) HCV-antibody negative by HCV-RNA testing. Delayed seroconversion in immunosuppressed patients may result in retarded diagnosis and treatment. Therefore, HCV-RNA testing should be part of the initial evaluation. Read More

Mol Med Rep 2019 Mar 19. Epub 2019 Mar 19.

Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Extra‑hepatic manifestations are frequently observed in hepatitis C virus (HCV)‑infected patients; however the underlying mechanisms remain largely unknown. In the present study, the human glioblastoma SF268 cell line (the precise origin of the cell type is not clear) was infected with HCV using HCV‑positive serum, and viral replication was assessed by immunofluorescence, reverse transcription‑polymerase chain reaction (PCR), quantitative PCR and western blotting following infection. HCV core protein and HCV RNA were detected in HCV‑positive serum‑infected SF268 cells at day 4 post‑infection, while no infection was observed in cells exposed to HCV‑negative serum. Read More

Mol Med Rep 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

Congenital heart disease (CHD), and cleft lip and palate (CLP) are currently the most common types of structural malformation in infants. Various methods have been used to identify the disease‑associated genes. However, targeted next‑generation sequencing (NGS) is not yet considered an option for routine use. Read More

Int J Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, P.R. China.

After the publication of the article, the authors retrospectively noticed that the first author affiliation was incorrectly split across three affiliations for the various parts of the same address. The correct author list (and affiliations) should therefore have been published as follows: Fengting Liu1, Lili Li1, Yanxia Li2, Xiaofang Ma3, Xiyun Bian2, Xiaozhi Liu2, Guowen Wang1* and Dianying Zhang3* 1Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060; 2Central Laboratory, The Fifth Central Hospital of Tianjin, Tianjin 300450; 3Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, P.R. Read More

Mol Med Rep 2019 Mar 13. Epub 2019 Mar 13.

Department of Clinical Laboratory Medicine, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, P.R. China.

The carcinoembryonic antigen, glypican‑3 (GPC3), is a putative therapeutic target and diagnostic marker of hepatoma. In the present study, a monoclonal antibody (mAb) specifically against GPC3 was obtained via cloning the sequence of GPC3 via polymerase chain reaction and inserting it into a pET16b vector prior to transfection into Escherichia coli (E. coli) BL21. Read More

Mol Med Rep 2019 Mar 18. Epub 2019 Mar 18.

Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang‑Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

MicroRNAs (miRNAs) are novel key regulators of cellular differentiation. miR‑124 has been reported to regulate osteogenic differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs). However, the specific mechanisms involved have not yet been fully elucidated. Read More

Mol Med Rep 2019 Mar 19. Epub 2019 Mar 19.

Department of Medical Oncology, Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China.

The study aimed to elucidate the mechanisms underlying the occurrence and development of lung adenocarcinoma, and to reveal long non‑coding RNA (lncRNA) prognostic factors to identify patients at high risk of disease recurrence or metastasis. Based on extensive RNA sequencing data and clinical survival prognosis information from patients with lung adenocarcinoma, obtained from The Cancer Genome Atlas and the Gene Expression Omnibus databases, a co‑expression network of lncRNAs with different expression levels was built using weighted correlation network analysis and MetaDE.ES. Read More

Mol Med Rep 2019 Mar 18. Epub 2019 Mar 18.

Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.

Post‑operative cognitive dysfunction is a common complication after anesthesia and surgery. Sevoflurane (SEV), a widely used inhalational anesthetic, can exaggerate neuroinflammation and cause cognitive dysfunction under chronic intermittent hypoxia (CIH) conditions by downregulating hippocampal peroxisome proliferator‑activated receptor‑γ (PPAR‑γ). In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH. Read More

Mol Med Rep 2019 Mar 14. Epub 2019 Mar 14.

Department of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P.R. China.

Transcription intermediary factor 1γ (Tif1γ), a ubiquitous nuclear protein, is a regulator of transforming growth factor‑β (TGF‑β)/Smad signaling. Tif1γ can function as an oncogene and as a tumor suppressor. In the present study, Tif1γ levels were measured in the plasma of patients with breast cancer in order to investigate the association of Tif1γ with overall survival (OS). Read More

Mol Med Rep 2019 Mar 15. Epub 2019 Mar 15.

Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China.

MicroRNAs (miRNAs) are pivotal regulators of the progression of carcinogenesis and negatively regulate the expression of tumour‑associated genes. Downregulation of miR‑124 expression has been demonstrated in various human cancer tissues, wherein miR‑124 serves as a tumour suppressor by targeting oncogenes. However, its function and underlying mechanism of action remain unclear in breast cancer. Read More

Int J Oncol 2019 Mar 19. Epub 2019 Mar 19.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.

Emerging evidence indicates that mesenchymal stem cells (MSCs) serve an indispensable role in the tumor microenvironment. However, whether MSCs participate in the development of oral carcinogenesis remains unclear. The present study isolated MSCs from clinical tissues and investigated the differences of MSCs derived from normal oral mucosa (N‑MSC), oral leukoplakia with dysplasia (LK‑MSC) and oral carcinoma (Ca‑MSC). Read More