4,691 results match your criteria Central Sleep Apnea


Prevalence and Factors Contributing to Daytime and Nocturnal Hypoxemia in Chronic Heart Failure Patients.

Respiration 2019 Jan 17:1-10. Epub 2019 Jan 17.

Laboratoire HP2, INSERM U 1042, Grenoble Alpes University, Grenoble, France.

Background: Despite clinical optimization, many chronic heart failure (CHF) patients remain symptomatic with dyspnea and poor quality of life.

Study Objective: While oxygen therapy is prescribed in severe cases, the actual prevalence of different patterns of hypoxemia is unknown.

Methods: We analyzed 183 stable CHF patients with optimized medical treatment in the "MARS" database. Read More

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http://dx.doi.org/10.1159/000490734DOI Listing
January 2019

Successful screening of sleep-disordered breathing using a pacemaker-based algorithm in Japan.

J Cardiol 2019 Jan 7. Epub 2019 Jan 7.

Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio-renal Medicine, Yokohama, Japan.

Background: Recent pacemakers with transthoracic impedance sensors have a specific algorithm identifying sleep apnea (SA). Our aim was to evaluate the algorithm in Japanese patients.

Methods: Consecutive patients implanted with a pacemaker with sleep apnea monitoring algorithm at our hospital were enrolled prospectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09145087183034
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http://dx.doi.org/10.1016/j.jjcc.2018.10.007DOI Listing
January 2019
2 Reads

Activation of Phox2b-expressing neurons in the nucleus tractus solitarii drives breathing in mice.

J Neurosci 2019 Jan 9. Epub 2019 Jan 9.

Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, 050017, China

The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but the neuronal phenotype and circuit mechanism involved in such a physiological function remain incompletely understood. This study focused on the respiratory role of paired-like homeobox 2b gene (Phox2b)-expressing NTS neurons and sought to determine whether selective stimulation of this set of neurons activates breathing in male mice. A Cre-dependent vector encoding a Gq-coupled human M3 muscarinic receptor (hM3Dq) was microinjected into the NTS of Phox2b-Cre transgenic mice. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2048-18.2018DOI Listing
January 2019
6.344 Impact Factor

Effects of Adaptive Servoventilation Therapy for Central Sleep Apnea on Health Care Utilization and Mortality: A Population-Based Study.

J Clin Sleep Med 2019 Jan 3. Epub 2019 Jan 3.

Study Objectives: Adaptive servoventilation (ASV) is the suggested treatment for many forms of central sleep apnea (CSA). We aimed to evaluate the impact of treating CSA with ASV on health care utilization.

Methods: In this population-based study using the Rochester Epidemiology Project database, we identified patients over a 9-year period who were diagnosed with CSA (n = 1,237), commenced ASV therapy, and had ≥ 1 month of clinical data before and after ASV initiation. Read More

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January 2019
1 Read

Polysomnography Findings and Sleep Disorders in Children With Alternating Hemiplegia of Childhood.

J Clin Sleep Med 2019 Jan 3. Epub 2019 Jan 3.

Study Objectives: Patients with alternating hemiplegia of childhood (AHC) experience bouts of hemiplegia and other paroxysmal spells that resolve during sleep. Patients often have multiple comorbidities that could negatively affect sleep, yet sleep quality and sleep pathology in AHC are not well characterized. This study aimed to report sleep data from both polysomnography (PSG) and clinical evaluations in children with AHC. Read More

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January 2019
2 Reads

Fractional Exhaled Nitric Oxide Measurements and Screening of Obstructive Sleep Apnea in a Sleep-Laboratory Setting: A Cross-Sectional Study.

Lung 2019 Jan 2. Epub 2019 Jan 2.

Department of Child Health, University of Missouri School of Medicine, Columbia, MO, USA.

Purpose: Obstructive sleep apnea (OSA) is a common condition characterized by repetitive collapse of the upper airways and intermittent oxygen desaturation, which may lead to airway inflammation. Here, we explored whether fractional exhaled nitric oxide (FeNO) levels provide a non-invasive screening tool of OSA.

Methods: Over a 3-month period, FeNO levels were measured in consecutive non-smoking patients referred for a sleep laboratory. Read More

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http://dx.doi.org/10.1007/s00408-018-0190-yDOI Listing
January 2019

Increase in Body Mass Index Decreases Duration of Apneas and Hypopneas in Obstructive Sleep Apnea.

Respir Care 2019 Jan;64(1):77-84

Department of Clinical Neurophysiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.

Background: Obesity is one of the most prominent risk factors for obstructive sleep apnea (OSA). Weight loss decreases the number of shorter respiratory events (<40 s), whereas the number of longer events remains almost unchanged. However, it is unknown how body mass index (BMI) affects individual obstruction event severity within OSA severity categories when age, sex, smoking, daytime sleepiness, snoring, hypertension, heart failure, and sleeping posture are considered. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06297
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http://dx.doi.org/10.4187/respcare.06297DOI Listing
January 2019
6 Reads

Tonsillectomy using the BiZact: A pilot study in 186 children and adults.

Clin Otolaryngol 2018 Dec 21. Epub 2018 Dec 21.

The Department of Otorhinolaryngology, Head and Neck Surgery, The Royal Adelaide Hospital, Adelaide, South, Australia.

1.The BiZact tonsillectomy device, produced by Medtronic (Minneapolis, MN, USA), was approved for market use in Australia by the Therapeutics Good Administration (TGA) in 2016 and is a new device for tonsillectomy 2.Results from this pilot study of 186 patients demonstrate a post-operative hemorrhage rate of 4. Read More

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http://dx.doi.org/10.1111/coa.13273DOI Listing
December 2018
1 Read
2.268 Impact Factor

Marfan syndrome: improved clinical history results in expanded natural history.

Authors:
Reed E Pyeritz

Genet Med 2018 Dec 21. Epub 2018 Dec 21.

Departments of Medicine and Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Life expectancy for a person with Marfan syndrome has essentially doubled over the past four decades. During this period, the clinical histories of the organs managed routinely have improved, and will continue to be. Prominent examples are the eyes, the heart and aorta, and some features of the skeletal system. Read More

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http://dx.doi.org/10.1038/s41436-018-0399-4DOI Listing
December 2018

Postconvulsive central apnea and asystole: A risk marker for sudden unexpected death in epilepsy (SUDEP)?

Neurology 2019 Jan 19;92(3):115-116. Epub 2018 Dec 19.

From the Mayo Center for Sleep Medicine (E.K.S.L.); Departments of Neurology (E.K.S.L.) and Medicine (E.K.S.L.), Mayo Clinic and Foundation, Rochester, MN; and Department of Neurology (B.A.D.), Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006765DOI Listing
January 2019

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Neurology 2019 Jan 19;92(3):e171-e182. Epub 2018 Dec 19.

From the NINDS Center for SUDEP Research (L.V., M.R.S.R., R.K.S., D.F., M.N., C.S., B.K.G., B.Z., A.Z., S.S., J.O., R.M.H., B.D., L.B., O.D., G.B.R., P.R., S.D.L.); Epilepsy Center (L.V., N.L., J.P.H., N.J.H., N.S., X.Z., V.R.-M., S.D.L.) and Division of Pulmonary, Critical Care and Sleep Medicine (K.S.), University Hospitals Cleveland Medical Center, OH; University of Iowa School of Medicine (R.K.S., B.K.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.S., B.D.), University College London, UK; Feinberg School of Medicine (S.S.), Northwestern University, Chicago, IL; Department of Neurobiology and Brain Research Institute (J.O., R.M.H.), University of California, Los Angeles (UCLA); Department of Neurology (L.B.), Columbia University, New York, NY; and Department of Clinical Neuroscience (P.R.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Objective: To characterize peri-ictal apnea and postictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy.

Methods: This was a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of sudden unexpected death in epilepsy (SUDEP) in patients ≥18 years old with intractable epilepsy and monitored GCS. Video-EEG, thoracoabdominal excursions, nasal airflow, capillary oxygen saturation, and ECG were analyzed. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006785DOI Listing
January 2019
7 Reads

Derivation and validation of a clinical prediction rule for sleep apnoea syndrome for use in primary care.

BJGP Open 2018 Jul 16;2(2):bjgpopen18X101481. Epub 2018 May 16.

Research Fellow, Araba Research Unit, Araba University Hospital, OSI-Araba, Vitoria-Gasteiz, Spain.

Background: Several clinical prediction rules (CPRs) are available for sleep apnoea-hypopnoea syndrome (OSAH), but they are difficult to apply in primary care (PC).

Aim: Derivation and validation of a CPR using simple measurements available in PC.

Design & Setting: A prospective study conducted in health centres from the area of influence of three Spanish hospitals. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184092PMC

Death in patients with adaptive servo-ventilation for sleep apnea and no specific SERVE-HF profile: A case series study.

Respir Med Case Rep 2019 26;26:68-72. Epub 2018 Nov 26.

Haut-Leveque Cardiology Hospital, Pessac, France.

Purpose: The SERVE-HF study reported a risk of cardiovascular death associated with adaptive servo-ventilation (ASV) for central sleep apnea in patients with chronic heart failure with reduced left ventricular ejection fraction (LVEF). Therefore, we adopted in May 2015 a safety procedure in our 32 patients with ASV since 2006. It led to ASV removal in four patients due to ≤45% LVEF. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277244PMC
November 2018

Use of the Clinical Global Impression scale in sleep apnea patients - Results from the ESADA database.

Sleep Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Sleep Medicine, Sahlgrenska University Hospital, Sweden; Sahlgrenska Academy, Gothenburg University, Sweden. Electronic address:

Objective/background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA).

Patients/methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.028DOI Listing
November 2018

Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Periodic limb movements in sleep (PLMS) are associated with adverse outcomes in patients with heart failure (HF). The aim of this study was to investigate whether PLMS change in response to adaptive servo-ventilation (ASV) for central sleep apnea (CSA) in patients with HF. We examined polysomnographic studies conducted between 2010 and 2014 at Mayo Clinic, Rochester, Minnesota (n = 14,444). Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.014DOI Listing
November 2018

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring.

Neurology 2019 Jan 14;92(3):e194-e204. Epub 2018 Dec 14.

From the Departments of Medicine (S.S., Z.C., A.P., C.J.R., N.C.J., C.F., P.P., P.K., T.J.O.), Neurology (S.S., E.J.W., A.P., C.H., J.C., C.J.R., R.Y., C.F., P.P., P.K., T.J.O.), and Respiratory and Sleep Disorders Medicine (T.M., J.G.), The Royal Melbourne Hospital, The University of Melbourne, Parkville; Department of Neuroscience (S.S., Z.C., A.P., N.C.J., C.F., P.P., P.K., T.J.O.), Central Clinical School, Monash University; Department of Neurology (S.S., A.P., P.P., P.K., T.J.O.), The Alfred Hospital; and Neuropsychiatry Unit (S.F., D.V.), The Royal Melbourne Hospital and Melbourne Neuropsychiatry Centre, Australia.

Objective: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychogenic nonepileptic seizures (PNES).

Methods: We conducted a cross-sectional study of consecutive patients admitted for inpatient video-EEG monitoring at The Royal Melbourne Hospital, Australia, between December 1, 2011, and July 31, 2017. Participants underwent routine clinical investigations during their monitoring period including polysomnography, neurocognitive testing, and screening instruments of daytime somnolence, sleep quality, and quality of life. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006776DOI Listing
January 2019

Feature relevance in physiological networks for classification of obstructive sleep apnea.

Physiol Meas 2018 Dec 21;39(12):124003. Epub 2018 Dec 21.

Center of Biomedical Image and Information Processing, HTW Berlin-University of Applied Sciences Berlin, Berlin, Germany. Sleep Medicine Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Objective: Physiological networks (PN) model couplings between organs in a high-dimensional parameter space. Machine learning methods, in particular artifical neural networks (ANNs), are powerful on high-dimensional classification tasks. However, lack of interpretability of the resulting models has been a drawback in research. Read More

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http://dx.doi.org/10.1088/1361-6579/aaf0c9DOI Listing
December 2018
1 Read

Continuous positive airway pressure for adults with obstructive sleep apnea and cardiovascular disease: a meta-analysis of randomized trials.

Sleep Med 2018 Oct 30;54:28-34. Epub 2018 Oct 30.

Postgraduate Programs in Health Sciences and in Public Health, Respiratory Division, Federal University of Rio Grande, Rio Grande, Brazil. Electronic address:

Background: It remains uncertain whether continuous positive airway pressure (CPAP) therapy would significantly impact hard clinical outcomes in patients with obstructive sleep apnea (OSA). This meta-analysis aimed to assess the effects of CPAP in survival and secondary prevention of major cardiovascular events in patients with OSA and cardiovascular disease (CVD).

Methods: PubMed, Cochrane CENTRAL, LILACS, and SciElo databases (up to January 2018) were searched for randomized trials that compared CPAP with no active treatment in adults with OSA and CVD. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.030DOI Listing
October 2018

The Value of a Well-Trained Ear: Incidental Detection of Catathrenia on Home Sleep Apnea Tests in Patients With Low Probability for Obstructive Sleep Apnea.

Authors:
Louis Kazaglis

J Clin Sleep Med 2018 Dec 15;14(12):2083-2086. Epub 2018 Dec 15.

Fairview Health Services, Minneapolis, Minnesota; University of Minnesota, Minneapolis, Minnesota.

Abstract: Catathrenia is a rare sleep-related breathing disorder marked by nocturnal groaning during prolonged exhalation. Home sleep apnea tests are growing in popularity, but no prior case reports exist documenting catathrenia detected by a home sleep apnea test. We report two cases of catathrenia incidentally detected in patients with low to intermediate risk of obstructive sleep apnea, in which diagnostic polysomnography was recommended but denied by insurers. Read More

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http://dx.doi.org/10.5664/jcsm.7544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287729PMC
December 2018
1 Read

The Evolution of Sleep Apnea Six Months After Acute Ischemic Stroke and Thrombolysis.

J Clin Sleep Med 2018 Dec 15;14(12):2005-2011. Epub 2018 Dec 15.

Department of Neurology, Oulu University Hospital and University of Oulu, Oulu, Finland.

Study Objectives: Our goal was to investigate the evolution of prevalence, severity, and type of sleep apnea among patients who had an ischemic stroke, with or without treatment with thrombolysis after 6 months.

Methods: We prospectively studied 204 patients who had an ischemic stroke (110 in the thrombolysis and 94 in the non-thrombolysis group). After follow-up, 177 patients were eligible for a final analysis (98 in the thrombolysis group and 79 in the non-thrombolysis group). Read More

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http://dx.doi.org/10.5664/jcsm.7524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287720PMC
December 2018
1 Read

Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length.

J Clin Sleep Med 2018 Dec 15;14(12):2037-2045. Epub 2018 Dec 15.

Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.

Study Objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample.

Methods: As part of the EPISONO cohort (São Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. Read More

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http://dx.doi.org/10.5664/jcsm.7532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287731PMC
December 2018
1 Read

Comparison of Commonly Used Questionnaires to Identify Obstructive Sleep Apnea in a High-Risk Population.

J Clin Sleep Med 2018 Dec 15;14(12):2057-2064. Epub 2018 Dec 15.

Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia.

Study Objectives: Sleep apnea is associated with adverse health outcomes. Despite being an important comorbidity in obesity, type 2 diabetes, heart failure, and resistant hypertension, it is underdiagnosed in these patient groups. An inexpensive and readily accessible sleep apnea screening tool would help address this problem. Read More

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http://dx.doi.org/10.5664/jcsm.7536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287723PMC
December 2018
1 Read

Sleep and breathing disturbances in patients with chronic obstructive pulmonary disease traveling to altitude: a randomized trial.

Sleep 2018 Dec 4. Epub 2018 Dec 4.

Department of Respiratory Medicine, Sleep Disorders Center, University Hospital Zurich, Zurich, Switzerland and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

Study Objectives: Patients with chronic obstructive pulmonary disease (COPD) have impaired pulmonary gas exchange near sea level. The purpose of the current study was to investigate whether exposure to hypobaric hypoxia during a stay at altitude affects nocturnal oxygen saturation, breathing pattern, and sleep in patients with moderate to severe COPD.

Methods: Thirty-two patients with COPD, median age 67 years, FEV1 59% predicted, PaO2 68 mmHg, living below 800 m, underwent polysomnography and questionnaire evaluations in Zurich (490 m), and in Swiss Alpine villages at 1650 and 2590 m, for two nights each, in random order. Read More

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http://dx.doi.org/10.1093/sleep/zsy203DOI Listing
December 2018
2 Reads

Nocturnal blood pressure decrease in patients with chronic kidney disease and in healthy controls - significance of obstructive sleep apnea and renal function.

Int J Nephrol Renovasc Dis 2018 8;11:279-290. Epub 2018 Nov 8.

University Clinic in Nephrology and Hypertension, Holstebro Hospital and Aarhus University, Holstebro, Denmark,

Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-matched controls. Read More

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http://dx.doi.org/10.2147/IJNRD.S176606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231441PMC
November 2018
2 Reads

Treatment-emergent central sleep apnoea after surgery for obstructive sleep apnoea.

Acta Otorhinolaryngol Ital 2018 Oct;38(5):476-479

UOC di Otorinolaringoiatria, Dipartimento Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Otorinolaringoiatria, Università Cattolica del Sacro Cuore, Roma, Italia.

Central sleep apnoea (CSA) is a lack of drive to breathe during sleep, which can occur in physiologic as well as in pathologic conditions. A particular type of CSA, defined treatment-emergent CSA (TECSA), may occur after the treatment of obstructive sleep apnoea syndrome (OSAS), either with CPAP or surgery. TECSA is transitory and seems to be related to the severity of OSAS. Read More

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http://dx.doi.org/10.14639/0392-100X-1476DOI Listing
October 2018

Required CPAP usage time to normalize AHI in obstructive sleep apnea patients: a simulation study.

Physiol Meas 2018 Nov 28;39(11):115009. Epub 2018 Nov 28.

Department of Clinical Neurophysiology, Seinäjoki Central Hospital, Seinäjoki, Finland. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland. Author to whom any correspondence should be addressed.

Objective: Adherence to continuous positive airway pressure (CPAP) is often limited. The aim of the current work was to create a simulation tool to enable determination of the individual CPAP therapy time required to normalize apnea-hypopnea index (AHI) (<5 events h) in a cohort of OSA patients.

Approach: Polygraphic studies of 1989 consecutive patients were analyzed. Read More

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http://stacks.iop.org/0967-3334/39/i=11/a=115009?key=crossre
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http://dx.doi.org/10.1088/1361-6579/aae7feDOI Listing
November 2018
3 Reads

Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality.

J Crit Care 2018 Nov 15;50:59-65. Epub 2018 Nov 15.

Radboud University Medical Center, Department of Intensive Care Medicine, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

Purpose: While most influenza patients have a self-limited respiratory illness, 5-10% of hospitalized patients develop severe disease requiring ICU admission. The aim of this study was to identify influenza-specific factors associated with ICU admission and mortality. Furthermore, influenza-specific pulmonary bacterial, fungal and viral co-infections were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183003
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http://dx.doi.org/10.1016/j.jcrc.2018.11.013DOI Listing
November 2018
19 Reads

Nocturnal enuresis in children is associated with differences in autonomic control.

Sleep 2018 Nov 26. Epub 2018 Nov 26.

Department of Pediatrics, Edmonton, Alberta, Canada.

Study Objectives: To assess the relationship between urine osmolality, cardiovascular parameters, and nocturnal enuresis in a population of children undergoing polysomnographic assessment.

Methods: This prospective observational study included consecutive children aged 5-17 years presenting for overnight polysomnography. Children were evaluated using continuous ambulatory blood pressure monitoring to assess heart rate and blood pressure. Read More

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http://dx.doi.org/10.1093/sleep/zsy239DOI Listing
November 2018
1 Read

Ullanlinna Narcolepsy Scale in Diagnosis of Narcolepsy.

Sleep 2018 Nov 26. Epub 2018 Nov 26.

Helsinki Sleep Clinic, Vitalmed Research Centre, Finland.

Study Objectives: To validate Ullanlinna Narcolepsy Scale (UNS) as a screening tool for narcolepsy in a clinical population and to compare it with Swiss Narcolepsy Scale (SNS) and Epworth Sleepiness Scale (ESS).

Methods: UNS questionnaires of 267 subjects visiting Helsinki Sleep Clinic were analyzed. The diagnoses of the subjects were narcolepsy type 1 (NT1, n = 89), type 2 (NT2, n = 10), other hypersomnias (n = 24), sleep apnea (n = 37), restless legs or periodic limb movement disorder (n = 56), and other sleep-related disorders (n = 51). Read More

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https://academic.oup.com/sleep/advance-article/doi/10.1093/s
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http://dx.doi.org/10.1093/sleep/zsy238DOI Listing
November 2018
13 Reads

Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA).

Sleep Breath 2018 Nov 22. Epub 2018 Nov 22.

Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital, P.O. Box 52, SF-20521, Turku, Finland.

Purpose: The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Read More

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http://dx.doi.org/10.1007/s11325-018-1757-9DOI Listing
November 2018
6 Reads

CO-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death.

Cardiovasc Pathol 2019 Jan - Feb;38:42-45. Epub 2018 Oct 26.

"Lino Rossi" Research Center, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy. Electronic address:

Introduction: In 2015, a multinational randomized controlled phase IV clinical trial of adaptive servoventilation for the management of heart failure with central sleep apnea was halted in progress because more patients in the study group were dying than in the control group. One year later, another large clinical trial reported results on the effectiveness of continuous positive airway pressure (CPAP) in preventing sudden death and other cardiovascular events such as heart attack and stroke in patients with preexisting vascular disease as well as obstructive sleep apnea.

Background: Sudden unexpected death has been associated with many types of small and nonmalignant medullary brain lesions, like demyelination plaques - largely asymptomatic until they caused sudden death. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.10.009DOI Listing
October 2018
5 Reads
2.340 Impact Factor

Factors related to excessive sleepiness in patients with Parkinson's disease.

Neurol Res 2018 Nov 21:1-7. Epub 2018 Nov 21.

c Department of Neuroscience, Faculty of Medicine of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.

Introduction: Excessive sleepiness (ES) can affect up to 60% of Parkinson's disease (PD) patients, and it has a multifactorial etiology. It is related to the neurodegenerative processes affecting brain regions responsible for the sleep-wake cycle, the effects of drugs acting on the central nervous system, and the excessive sleep fragmentation of this population.

Objectives: To identify the factors associated with the presence of ES in patients with PD. Read More

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http://dx.doi.org/10.1080/01616412.2018.1548746DOI Listing
November 2018
12 Reads

Autonomic aspects of sudden unexpected death in epilepsy (SUDEP).

Clin Auton Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Neurology, Jefferson Comprehensive Epilepsy Center, Sidney Kimmel Medical College at Thomas Jefferson University, 901 Walnut Street, Suite 400, Philadelphia, PA, 19107, USA.

Sudden unexpected death in epilepsy (SUDEP) is a major cause of epilepsy-related mortality. SUDEP is highly linked to seizures, with most deaths occurring after convulsive seizures in sleep. In most cases of SUDEP, convulsive seizures appear to directly trigger catastrophic cardiorespiratory dysfunction leading to death. Read More

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http://link.springer.com/10.1007/s10286-018-0576-1
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http://dx.doi.org/10.1007/s10286-018-0576-1DOI Listing
November 2018
8 Reads

Severe sleep apnea, Cheyne-Stokes respiration and desaturation in patients with decompensated heart failure at high altitude.

Sleep Sci 2018 May-Jun;11(3):146-151

Fundacion Neumologica Colombiana, Sleep Center - Bogota - DC - Colômbia.

Objectives: To determine the sleep-disordered breathing in patients with decompensated HF (DHF) at an altitude of 2640m.

Methods: Polysomnogram during the first 48 hours of admission in patients hospitalized for DHF. Sleep apnea (SA) was defined as an apnea hypopnea index (AHI) > 5/hour and central sleep apnea (CSA) as central apnea index (CAI) ≥ 50% of the AHI. Read More

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http://dx.doi.org/10.5935/1984-0063.20180028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201522PMC
November 2018
7 Reads

A retrospective study on sleep-disordered breathing in Morquio-A syndrome.

Am J Med Genet A 2018 Dec 18;176(12):2595-2603. Epub 2018 Nov 18.

Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.

Respiratory problems are common in Morquio-A syndrome (MPS IVA) but objective data on sleep-disordered breathing are scarce. The aim of our study was to review polygraphic (PG) findings and the need for noninvasive continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in children with MPS IVA. A retrospective review of the clinical charts and PG of 16 consecutive children (7 boys, mean age 10. Read More

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http://doi.wiley.com/10.1002/ajmg.a.40642
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http://dx.doi.org/10.1002/ajmg.a.40642DOI Listing
December 2018
12 Reads

Upper airway stimulation in obstructive sleep apnea improves glucose metabolism and reduces hedonic drive for food.

J Sleep Res 2018 Nov 19:e12794. Epub 2018 Nov 19.

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Upper airway stimulation is a new and effective second-line treatment for obstructive sleep apnea, but possible consequences on glucose metabolism and central regulation of food intake are unclear. Twenty patients were prospectively studied before and 12 months after obstructive sleep apnea treatment by upper airway stimulation. Respiratory parameters and daytime sleepiness were assessed to document effectiveness of treatment. Read More

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http://dx.doi.org/10.1111/jsr.12794DOI Listing
November 2018
1 Read

Obstructive sleep apnea syndrome in children.

Authors:
Cristina Perez

Gen Dent 2018 Nov-Dec;66(6):46-50

Obstructive sleep apnea syndrome (OSAS) in children is defined as a "disorder of breathing during sleep characterized by prolonged partial upper airway obstruction [hypopnea] and/or intermittent complete obstruction (obstructive apnea) that disrupts normal ventilation during sleep and normal sleep patterns." OSAS is both prevalent and underdiagnosed in children. OSAS has harmful central nervous system, cardiovascular, and metabolic consequences, which can include an inability to concentrate in school, poor academic performance, behavioral problems, cardiovascular effects, and poor growth and development. Read More

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November 2018
4 Reads

Clinical and Experimental Human Sleep-Wake Pharmacogenetics.

Handb Exp Pharmacol 2018 Nov 16. Epub 2018 Nov 16.

Wisconsin Institute for Sleep and Consciousness, University of Wisconsin Madison, Madison, WI, USA.

Sleep and wakefulness are highly complex processes that are elegantly orchestrated by fine-tuned neurochemical changes among neuronal and non-neuronal ensembles, nuclei, and networks of the brain. Important neurotransmitters and neuromodulators regulating the circadian and homeostatic facets of sleep-wake physiology include melatonin, γ-aminobutyric acid, hypocretin, histamine, norepinephrine, serotonin, dopamine, and adenosine. Dysregulation of these neurochemical systems may cause sleep-wake disorders, which are commonly classified into insomnia disorder, parasomnias, circadian rhythm sleep-wake disorders, central disorders of hypersomnolence, sleep-related movement disorders, and sleep-related breathing disorders. Read More

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http://dx.doi.org/10.1007/164_2018_175DOI Listing
November 2018
18 Reads

Systematic Comparison of Respiratory Signals for the Automated Detection of Sleep Apnea.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:449-452

Sleep apnea is one of the most common sleep disorders. It is characterized by the cessation of breathing during sleep due to airway blockages (obstructive sleep apnea) or disturbances in the signals from the brain (central sleep apnea). The gold standard for diagnosing sleep apnea is performing an overnight polysomnography recording which contains, among others, a wide array of respiratory signals. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512307DOI Listing
July 2018
4 Reads

Analysis of Features Extracted from EEG Epochs by Discrete Wavelet Decomposition and Hilbert Transform for Sleep Apnea Detection.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:287-290

Sleep apnea (SA) is one of the most common disorders manifesting during sleep and the electroencephalo-gram (EEG) belongs to these biomedical signals that change during apnea and hypopnea episodes. In recent years, a few publications reported approaches to the automatic classification of sleep apnea episodes based only on the EEG. The purpose of this work was to analyze statistical features extracted from the EEG epochs by combined discrete wavelet transform (DWT) and Hilbert transform (HT). Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512201DOI Listing
July 2018
1 Read

Multicenter, Prospective Study on Respiratory Stability During Recovery From Deterioration of Chronic Heart Failure.

Circ J 2018 Dec 13;83(1):164-173. Epub 2018 Nov 13.

Cardiovascular Medicine, Jichi Medical University Saitama Medical Center.

Background: The respiratory instability frequently observed in advanced heart failure (HF) is likely to mirror the clinical status of worsening HF. The present multicenter study was conducted to examine whether the noble respiratory stability index (RSI), a quantitative measure of respiratory instability, reflects the recovery process from HF decompensation. Methods and Results: Thirty-six of 44 patients hospitalized for worsening HF completed all-night measurements of RSI both at deterioration and recovery phases. Read More

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https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_C
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http://dx.doi.org/10.1253/circj.CJ-18-0519DOI Listing
December 2018
5 Reads

Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.

J Diabetes Res 2018 22;2018:1567683. Epub 2018 Oct 22.

Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Objective: Individuals with multiple metabolic risk factors often experience concomitant sleep-disordered breathing (SDB). We aimed to determine the associations of SDB with individual components of metabolic syndrome independent of obesity.

Methods: A cross-sectional study was conducted in 1137 employees aged 30-64 years. Read More

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https://www.hindawi.com/journals/jdr/2018/1567683/
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http://dx.doi.org/10.1155/2018/1567683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217749PMC
October 2018
6 Reads

Predictors of One Year Compliance with Adaptive Servo-Ventilation in Patients with Heart Failure and Sleep- Disordered Breathing: Preliminary Data from the ADVENT-HF Trial.

Eur Respir J 2018 Nov 8. Epub 2018 Nov 8.

Sleep Research Laboratory of the University Health Network Toronto Rehabilitation Institute, Toronto, Canada.

Peak flow-targeted adaptive servo ventilation (ASVpf) suppresses both obstructive (OSA) and central sleep apnoea (CSA). Although high hours of positive airway pressure (PAP) use improves quality of life, long-term compliance is problematic. We evaluated ASVpf use in patients with heart failure and reduced ejection fraction with either OSA or CSA to determine the short and long-term predictors of ASV pf compliance. Read More

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http://dx.doi.org/10.1183/13993003.01626-2018DOI Listing
November 2018
1 Read

Association of Acromegaly and Central Sleep Apnea Syndrome.

Turk Thorac J 2017 Nov 29:1-3. Epub 2017 Nov 29.

Department of Radiology, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.

Acromegaly is usually characterized by the excessive secretion of growth hormone (GH) after the closure of epiphyseal plaques, resulting from functional pituitary adenomas. The most common manifestations of acromegaly are acral and soft tissue overgrowth, diabetes mellitus, hypertension, and heart and respiratory failure. In patients, obstruction of the upper airway may develop due to enlargement of the tongue and thickening of the tissues of the larynx; consequently, obstructive sleep apnea syndrome (OSAS) occurs commonly in acromegaly. Read More

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http://turkthoracj.org/eng/makale/932/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2017.17003DOI Listing
November 2017
15 Reads

[The relationship between the changes of serum NGF, HO-1, IL-1 beta and cognitive function in patients with severe OSAHS after comprehensive treatment].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(20):1568-1571

Department of Otorhinolaryngology Head and Neck Surgery, Loudi Central Hospital.

To explore the relationship between the levels of serum nerve growth factor(NGF), hemeoxygenase 1(HO-1),interleukin-1 beta (IL-1β) and cognitive function in OSAHS patients. the levels of serum NGF, HO-1 and IL-1β concentrations in 60 severe OSAHS patients were measured before and after treatment, and the Montreal cognitive score (MoCA), AHI and the LSaO₂ were also recorded. ①OSAHS patients have serum NGF decreased and serum HO-1, IL-1β increased. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.20.008DOI Listing
October 2018
9 Reads

[Gastroesophageal reflux disease is associated with high risk of obstructive sleep apnea syndrome].

Zhonghua Nei Ke Za Zhi 2018 Nov;57(11):824-829

Department of Gastroenterology, The Central Hospital of Longhua District, Shenzhen 518110, China.

To investigate the relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea syndrome(OSAS). Patients diagnosed as GERD and healthy controls without GERD related symptoms or endoscopic esophagitis were enrolled from October 2017 and December 2017. All subjects completed Berlin Questionaire to assess the risk of OSAS. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2018.11.006DOI Listing
November 2018
5 Reads

Comparative Sleep Disturbances in Myotonic Dystrophy Types 1 and 2.

Curr Neurol Neurosci Rep 2018 Oct 31;18(12):102. Epub 2018 Oct 31.

System Medicine Department, University of Rome Tor Vergata, Rome, Italy.

Purpose Of Review: To update current knowledge regarding sleep disturbances and myotonic dystrophies so as to better understand if sleep symptoms may help in the early recognition of the two genetic subtypes: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2).

Recent Findings: Sleep-disordered breathing (SDB), restless legs syndrome, periodic limb movements in sleep, hypersomnia, and REM sleep dysregulation are frequently described in DM1 patients. SDB does not always explain hypersomnia, but a central dysregulation of sleep-wake modulation is reported mainly in DM1. Read More

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http://link.springer.com/10.1007/s11910-018-0903-x
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http://dx.doi.org/10.1007/s11910-018-0903-xDOI Listing
October 2018
4 Reads

Ventilatory and Autonomic Regulation in Sleep Apnea Syndrome: A Potential Protective Role for Erythropoietin?

Front Physiol 2018 16;9:1440. Epub 2018 Oct 16.

Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile.

Obstructive sleep apnea (OSA) is the most common form of sleep disordered breathing and is associated with wide array of cardiovascular morbidities. It has been proposed that during OSA, the respiratory control center (RCC) is affected by exaggerated afferent signals coming from peripheral/central chemoreceptors which leads to ventilatory instability and may perpetuate apnea generation. Treatments focused on decreasing hyperactivity of peripheral/central chemoreceptors may be useful to improving ventilatory instability in OSA patients. Read More

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http://dx.doi.org/10.3389/fphys.2018.01440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196773PMC
October 2018
1 Read

A 14-Month-Old Child With Gastroesophageal Reflux and Central Apnea.

J Clin Sleep Med 2018 Nov 15;14(11):1959-1960. Epub 2018 Nov 15.

University of Washington, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

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http://dx.doi.org/10.5664/jcsm.7504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223563PMC
November 2018
6 Reads