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Am J Physiol Regul Integr Comp Physiol 2019 Mar 20. Epub 2019 Mar 20.

Physiology and Anatomy, Univ. North Texas Health Sciences Center - Fort Worth, United States.

Chronic Intermittent Hypoxia (CIH) is a model of the hypoxemia from sleep apnea that causes a sustained increase in blood pressure. Inhibition of the central renin-angiotensin system or FosB in the median preoptic nucleus (MnPO) prevents the sustained hypertensive response to CIH. We tested the hypothesis that angiotensin type 1a (AT1a) receptors in the MnPO, which are upregulated by CIH, contribute to this hypertension. Read More

Front Neurol 2019 1;10:166. Epub 2019 Mar 1.

Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States.

Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e. Read More

Auton Neurosci 2019 May 30;218:54-63. Epub 2019 Jan 30.

Department of Neurology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Sleep and arousal from sleep are associated with profound changes in cardiovascular and respiratory functions. Fluctuations of arterial blood pressure (ABP), heart rate (HR), and respiration occur both during non-rapid eye movement (NREM) and REM sleep and during transitions between sleep and behavioral arousal. These changes reflect complex, state-dependent interactions among several neuronal groups in the hypothalamus and brainstem. Read More

Auton Neurosci 2019 May 15;218:10-15. Epub 2019 Feb 15.

Department of Neurology, Dysautonomia Center, New York University School of Medicine, New York, NY, United States of America. Electronic address:

Familial dysautonomia (Riley-Day syndrome, hereditary sensory and autonomic neuropathy type III) is a rare autosomal recessive disease characterized by impaired development of primary sensory and autonomic neurons resulting in a severe neurological phenotype, which includes arterial baroreflex and chemoreflex failure with high frequency of sleep-disordered breathing and sudden death during sleep. Although a rare disease, familial dysautonomia represents a unique template to study the interactions between sleep-disordered breathing and abnormal chemo- and baroreflex function. In patients with familial dysautonomia, ventilatory responses to hypercapnia are reduced, and to hypoxia are almost absent. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14859

Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan.

This retrospective, nationwide, matched cohort study investigated the risk of central serous chorioretinopathy (CSCR) following end-stage renal disease (ESRD). The study cohort included 84722 ESRD patients who were registered between January 2000 and December 2009 at the Taiwan National Health Insurance Research Database. An age- and sex-matched control group comprised 84722 patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 14. Epub 2019 Mar 14.

Service d'ORL et chirurgie cervico-faciale, UAM d'ORL pédiatrique, hôpital Gui-de-Chauliac, université de Montpellier, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France. Electronic address:

Objectives: Using respiratory polygraphy (RP) in children for diagnosis of obstructive sleep apnea/hypopnea syndrome (OSAHS) can be challenging in terms of device acceptance and sensor displacement. Automatic analysis of respiratory events has never been evaluated in a pediatric population. The primary objective of this study was to determine the feasibility of pediatric RP in routine ENT department practice. Read More

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Background And Objectives: Fluid overload and central sleep apnea are highly prevalent in patients with heart failure (HF). We performed this meta-analysis to assess the effects of acetazolamide therapy on acid/base balance and apnea indexes.

Methods: A literature search was conducted using EMBASE, MEDLINE, and Cochrane Database from inception through 18 November 2017 to identify studies evaluating the use of acetazolamide in HF. Read More

Anesthesiology 2019 Mar 11. Epub 2019 Mar 11.

From the Department of Anesthesiology, Graduate School of Medicine, Chiba University, Chiba, Japan (Y.K., S.I.) the Department of Anesthesiology, Showa University Koto Toyosu Hospital, Tokyo, Japan (Y.K., T.S.) the Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry, Tokyo, Japan (Y.K., S.O., A.K., T.I.) the Department of Dental Anesthesiology and Orofacial Pain, Graduate School of Dentistry, Kyusyu Dental University, Fukuoka, Japan (K.K.) the Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada (F.R.A.) the Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan (Y.S.).

What We Already Know About This Topic: Dental procedures under sedation can cause hypoxic events and even death. However, the mechanism of such hypoxic events is not well understood.

What This Article Tells Us That Is New: Apnea and hypopnea occur frequently during dental procedures under sedation. Read More

Scand J Caring Sci 2019 Mar 13. Epub 2019 Mar 13.

Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway.

Background: Sleep-disordered breathing, including obstructive sleep apnoea and central sleep apnoea, is a common disorder among patients with chronic heart failure. Obstructive sleep apnoea is often treated with continuous positive airway pressure, but central sleep apnoea lacks a clear treatment option. Knowledge of how sleep-disordered breathing is experienced (e. Read More

Caspian J Intern Med 2019 ;10(1):1-6

Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babal, Iran.

Efficiency of non-invasive positive pressure ventilation in the treatment of respiratory failure has been shown in many published studies. In this review article, we introduced new modalities of non-invasive ventilation (NIV), clinical settings in which NIV can be used and a practical summary of the latest official guidelines published by the European Respiratory Clinical Practice. Clinical trials and review articles in four databases up to 25 February 2018 about new modalities of non-invasive positive pressure ventilation were reviewed. Read More

J Clin Sleep Med 2019 Mar 5. Epub 2019 Mar 5.

Study Objectives: Polysomnography (PSG) is increasingly used in the assessment of infants. Newborn PSG reference values based on recent standardization are not available. This study provides reference values for PSG variables in healthy newborn infants. Read More

J Clin Sleep Med 2019 Mar 5. Epub 2019 Mar 5.

Abstract: A 12-year-old girl with normal neurodevelopment and narcolepsy type 1 presented with unexpected central apneas in response to sodium oxybate (SO). The patient underwent overnight polysomnography on SO (2.75 + 2. Read More

J Clin Sleep Med 2019 Mar 5. Epub 2019 Mar 5.

Study Objectives: Snoring is perceived to be directly proportional to sleep apnea severity, especially obstructive sleep apnea (OSA), but this notion has not been thoroughly and objectively evaluated, despite its popularity in clinical practice. This might lead to overdiagnosis or underdiagnosis of OSA. The goal of this study is to examine this notion and objectively quantify the relationship between sleep apnea and snoring detected using advanced signal processing algorithms. Read More

J Clin Sleep Med 2019 Mar 5. Epub 2019 Mar 5.

Study Objectives: Although Pierre Robin sequence (PRS) is a major cause of neonatal obstructive sleep apnea (OSA), longitudinal studies reporting evolution with age are lacking. This study aimed to describe changes in sleep-related respiratory parameters and sleep architecture in neonates with PRS treated conservatively (defined for this paper as treatment without tracheostomy or mandibular distraction).

Methods: A retrospective, 14-year, single-institution study of neonates with PRS who underwent diagnostic polysomnography (PSG) and at least one follow-up PSG. Read More

Clin Plast Surg 2019 Apr 8;46(2):249-259. Epub 2019 Feb 8.

Pediatric Plastic Surgery, Craniofacial Program, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 2 Dudley Street, Suite 180, Providence, RI 02905, USA. Electronic address:

Pierre Robin sequence consists of clinical triad of micrognathia, glossoptosis, and airway compromise with variable inclusion of cleft palate. Evaluation of airway obstruction includes physical examination, polysomnography for obstruction events, and a combination of nasoendoscopy and bronchoscopy to search for synchronous obstructive lesions. A multidisciplinary approach is required given the high rate of syndromic disease. Read More

Sleep Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Anesthesiology, Hospital for Special Surgery, New York, NY, USA; Department of Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria; Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY, USA.

Introduction: Although obstructive sleep apnea (OSA) is a known risk factor for perioperative complications in various patient cohorts data is lacking for patients undergoing hysterectomies, one of the most frequently performed surgeries among women. Using national data we therefore aimed to assess the risk in this patient group.

Materials And Methods: We extracted data on patients who underwent a hysterectomy between 2006 and 2014 from a large nationwide database (n = 459,508). Read More

J Cardiovasc Electrophysiol 2019 Mar 4. Epub 2019 Mar 4.

4th Military Hospital, Wroclaw, Poland.

Background: Central sleep apnea (CSA) is a breathing disorder caused by the intermittent absence of central respiratory drive. Transvenous phrenic nerve stimulation is a new therapeutic option, recently approved by the FDA , for the treatment of CSA.

Objective: To describe the technique used to implant the transvenous phrenic nerve stimulation system (the remedē System, Respicardia, Inc). Read More

Respir Med Case Rep 2019 16;26:273-275. Epub 2019 Feb 16.

Department of Cardiovascular Medicine, Matsumoto Kyoritsu Hospital, Matsumoto, Japan.

Sleep-disordered breathing (SDB) is one of the most common complications among heart failure (HF) patients. Changes of respiratory patterns during the various stages in patients with HF have not been fully investigated. In this case, the algorism using thoracic impedance sensor and minute ventilation (sleep apnea monitoring [SAM] algorithm) with implanted pacemaker (REPLY 200 SR or DR, Sorin CRM SAS, Clamart, France) was used to monitor respiration. Read More

Respir Res 2019 Feb 28;20(1):43. Epub 2019 Feb 28.

Department of Otolaryngology Head & Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2nd Anzhen Road, Chaoyang District, Beijing, 100029, China.

Background: There is a paucity of data from large prospective study evaluating the prognostic significance of the residual Synergy between percutaneous intervention with Taxus drug-eluting stents and cardiac surgery (SYNTAX) Score (rSS) in patients with obstructive sleep apnea (OSA) and Acute Coronary Syndrome (ACS).

Methods: ACS patients who undergoing percutaneous coronary angiography and completing a sleep study during hospitalization were prospectively enrolled. The baseline SYNTAX Score (bSS) and the rSS after revascularization were assessed. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Mar;33(3):246-250

Department of Otorhinolaryngology Head and Neck Surgery, the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.

To analyse the morphology and resilience of upper airway in patients with OSAHS using 128-slice MSCT. CT imaging of the upper airway in 49 patients with OSAHS was acquired in two respiratory status (quiet respiration and Müller maneuver). The two-dimensional measurements of retropalatal and retroglossal regions, airway volume, and airway resilience were measured in patients with severe OSAHS and non-severe OSAHS. Read More

Medicine (Baltimore) 2019 Feb;98(8):e14545

Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Background: Obstructive sleep apnea (OSA) is common among patients with chronic kidney disease (CKD). CKD may increase the risk of OSA, and OSA may increase the risk of renal injury. Nasal continuous positive airway pressure (nCPAP) is the standard treatment for OSA. Read More

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Pulmonary, Critical Care and Sleep Division. University of California at San Diego, CA, United States.

Study Objectives: To determine whether there is a consistent epiglottic pressure value that predicts respiratory arousal from sleep.

Methods: 31 patients with obstructive sleep apnea underwent overnight polysomnography while instrumented with an epiglottic catheter to measure airway pressures. Nadir epiglottic pressures during respiration events (obstructive apneas/hypopneas) terminated with or without arousals were compared. Read More

JAMA Netw Open 2019 Feb 1;2(2):e190067. Epub 2019 Feb 1.

Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland.

Importance: During mountain travel, patients with chronic obstructive pulmonary disease (COPD) are at risk of experiencing severe hypoxemia, in particular, during sleep.

Objective: To evaluate whether preventive dexamethasone treatment improves nocturnal oxygenation in lowlanders with COPD at 3100 m.

Design, Setting, And Participants: A randomized, placebo-controlled, double-blind, parallel trial was performed from May 1 to August 31, 2015, in 118 patients with COPD (forced expiratory volume in the first second of expiration [FEV1] >50% predicted, pulse oximetry at 760 m ≥92%) who were living at altitudes below 800 m. Read More

Exp Ther Med 2019 Mar 18;17(3):1766-1770. Epub 2018 Dec 18.

Department of Otolaryngology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.

The present study investigated the changes of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and sleep ability in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). A total of 684 patients who were admitted to Xuzhou Central Hospital between June 2012 and June 2016 were enrolled to serve as the experimental group and 192 healthy subjects were selected as the control group. Polysomnography was performed on both groups, and serum TNF-α and IL-8 levels were measured by ELISA. Read More

J Am Acad Dermatol 2019 Apr 13;80(4):1073-1113. Epub 2019 Feb 13.

Baylor Scott and White, Dallas, Texas.

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence. Read More

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):29-31

Wenzhou Central Hospital, Wenzhou, 325000.

This paper demonstrates a BSN-based portable monitor integrating micro sensors with mobile devices for monitoring and diagnosing obstructive sleep apnea syndrome (OSAS) at home. The system uses a micro hot-film flow sensor to detect respiratory flow, uses tri-axis micro accelerometer to detect body posture and motion intensity, and uses a micro photoelectric sensor to detect oxygen saturation of blood. The real-time vital signs are detected and transmitted wirelessly to a mobile device. Read More

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Biomedical Sciences, University of Missouri - Columbia, United States.

Infant rat pups lacking CNS serotonin (5-hydroxytryptamine; 5-HT) have unstable breathing during prolonged periods of active sleep. Given that cholinergic neurons are drivers of active sleep and project to respiratory patterning regions in the brainstem, we hypothesized that 5-HT preserves respiratory stability in active sleep by dampening central cholinergic drive. We used whole-body plethysmography coupled with nuchal EMG to monitor the breathing pattern of 2-week-old TPH2+/+ and TPH2-/- pups in active sleep, before and after muscarinic blockade. Read More

Sleep Sci 2018 Jul-Aug;11(4):211-214

Hypnos Instituto del Sueño, Sleep Medicine, Neurology - Lima - Lima - Peru.

Studies evaluating the association between Central Sleep Apnea (CSA) and positional sleep apnea are not commonly described and are barely understood. We report a case of a 51-year-old-male with moderate Obstructive Sleep Apnea (OSA) and severe CSA probably secondary to brainstem compression, which responded to the adoption of strict lateral body posture. The addition of Continuous Positive Airway Pressure (CPAP) optimally resolved the remaining obstructive respiratory events. Read More

J Sleep Res 2019 Feb 11:e12830. Epub 2019 Feb 11.

Sleep Unit, Department of Respiratory Medicine, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain.

Central obesity is the main risk factor for obstructive sleep apnea (OSA). Whether there exists a central-obesity anthropometric that better explains apnea-hypopnea index (AHI) variability in the general population and in sleep cohorts is unknown, and this is even less explored among increasing grades of obesity. The objective of the study is to investigate whether there is an anthropometric that better explains AHI variability in a sample of morbidly obese women awaiting bariatric surgery (BS). Read More

J Stomatol Oral Maxillofac Surg 2019 Feb 27;120(1):7-10. Epub 2018 Oct 27.

Service de stomatologie et chirurgie maxillo-faciale, AP-HP, DHU FAST, GH Pitié - Salpêtrière - Charles-Foix, 75013, Paris, France; Sorbonne Universités, UPMC université Paris 06, UMR 8256 B2A, 75005, Paris, France.

Introduction: Continuous positive airways pressure, generally used to treat obstructive sleep apnea-hypopnea syndrome (OSAHS), is not tolerated well by many patients. An alternative is to treat OSAHS with mandibular advancement devices (MAD). This research assesses the long term (> 2 years) effectiveness and the side effects on dental and skeletal parameters of these devices. Read More

Obes Surg 2019 Feb 8. Epub 2019 Feb 8.

Gastroenterology Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627. Morumbi, São Paulo, SP, 050652-900, Brazil.

Introduction: Epidemiological data have demonstrated that obesity is an important risk factor for the development of gastroesophageal reflux disease (GERD). The proportion of subjects with GERD symptoms can be as high as 50% for BMI > 30. Although still controversial in the literature, there are several studies associating sleeve gastrectomy (SG) with an increase in GERD prevalence. Read More

J Clin Sleep Med 2019 Feb 15;15(2):351-354. Epub 2019 Feb 15.

Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy.

Abstract: Respiratory disorders may follow brain injury and may also occur because of comorbidities and drug use, especially central depressants or muscle relaxants. Sleep can precipitate respiratory disorders, thus polysomnography can be a powerful diagnostic tool. By revealing breathing patterns that identify specific sleep disorders, polysomnography may unmask adverse pharmacological effects, for instance connecting central depressant drugs with central sleep apneas. Read More

J Clin Sleep Med 2019 Feb 15;15(2):285-292. Epub 2019 Feb 15.

Interdisciplinary Sleep Medicine Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Study Objectives: Evaluation of apnea detection using a tracheal sound (TS) sensor during sleep in patients with obstructive sleep apnea.

Methods: Polysomnographic recordings of 32 patients (25 male, mean age 66.7 ± 15. Read More

J Clin Sleep Med 2019 Feb 15;15(2):201-206. Epub 2019 Feb 15.

Centre for Sleep and Chronobiology (CIRUS), Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia.

Study Objectives: The aim of this study was to determine whether severity measures of obstructive sleep apnea (OSA) are associated with arterial stiffness and central blood pressure (two important cardiovascular risk factors) in a large group of patients with OSA.

Methods: Baseline data from six studies on OSA in which arterial stiffness and central aortic blood pressure measures were determined using applanation tonometry were pooled. Associations between measures of arterial stiffness (heart rate corrected augmentation index [AI75]), central aortic blood pressure (central systolic pressure [CSP] and heart rate corrected central augmentation pressure [CAP75]) and measures of OSA severity were explored using stepwise regression modelling. Read More

Sleep Breath 2019 Feb 8. Epub 2019 Feb 8.

Department of Child Health, University of Missouri School of Medicine, Columbia, MO, USA.

Purpose: Obstructive sleep apnea (OSA) is very common occurrence among morbidly obese patients. Our main objectives were to validate the No-Apnea, a 2-item screening tool, in morbidly obese patients and compare its performance with three other instruments: STOP-Bang questionnaire, NoSAS score, and Epworth Sleepiness Scale (ESS).

Methods: A cross-sectional analysis of morbidly obese patients (body mass index [BMI] ≥ 35. Read More

Mol Genet Genomic Med 2019 Feb 6:e596. Epub 2019 Feb 6.

Genetic and Metabolic Central Laboratory, Birth Defect Prevention Research Institute, Maternal and Child Health Hospital, Children's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Background: Heterozygous mutations in the AT-hook DNA-binding motif containing one (AHDC1, OMIM * 615790) gene cause an autosomal dominant multisystem developmental disorder known as Xia-Gibbs syndrome (OMIM #615829). Xia-Gibbs syndrome typically presented with global developmental delay, hypotonia, obstructive sleep apnea, seizures, delayed myelination, micrognathia, and other mild dysmorphic features.

Methods: Description of the clinical materials of two Chinese boys who were diagnosed with Xia-Gibbs syndrome based on clinical presentations and next generation sequencing. Read More

Sleep Breath 2019 Feb 7. Epub 2019 Feb 7.

Interdisciplinary Sleep Medicine Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: To determine if recording of suprasternal pressure (SSP) can classify apneas and hypopneas as reliably as respiratory inductance plethysmography (RIP) belts and to compare the two methods to classification with esophageal pressure (Pes), the reference method for assessing respiratory effort.

Methods: In addition to polysomnographic recordings that included Pes, SSP was recorded. Recordings from 32 patients (25 males, mean age 66. Read More

Chest 2019 Jan 31. Epub 2019 Jan 31.

Cleveland Clinic Sleep Disorders Center, Cleveland, OH. Electronic address:

Epilepsy is the fourth most common neurologic disorde in the United States, affecting over 2.2 million people. Epilepsy is associated with a number of medical and psychiatric comorbidities, higher health-care use and cost, and substantial economic burden. Read More

Sleep Med Clin 2019 Mar 5;14(1):83-89. Epub 2018 Dec 5.

Department of Plastic and Reconstructive Surgery, Craniofacial Center, Chang Gung Memorial Hospital, No. 5, Fuxing Road, Guishan District, Taoyuan 333, Taiwan; Esthetic Dent Clinic, No.380, Section 4, Xinyi Road, Da'an District, Taipei 106, Taiwan.

Obstructive sleep apnea is a medical syndrome with multifactorial pathophysiology. Surgery can be the primary treatment option when anatomic factors are identified with narrowing at specific or general levels of pharyngeal airway. The surgeries are directed to the etiologic anatomic structure to achieve greatest effectiveness. Read More

Sleep Med Clin 2019 Mar;14(1):109-118

Department of Orthodontics, National Dental Centre Singapore, 5 Second Hospital Avenue, Singapore 168938, Singapore.

Obstructive sleep apnea (OSA) is a multifactorial condition, and an interdisciplinary approach to diagnosis forms the basis for effective treatment planning. Craniofacial structure and attached soft tissues and muscles play a central role in OSA. Evidence-based studies demonstrate the effectiveness of oral appliances for mandibular advancement and tongue stabilization in managing OSA, and current clinical standards of practice recommend the use of oral appliances to treat OSA when patients cannot tolerate continuous positive airway pressure (CPAP). Read More

Int J Cardiol Heart Vasc 2019 Mar 17;22:117-122. Epub 2019 Jan 17.

Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Belisario Domínguez XVI, Tlalpan, Mexico City P. C. 14080, Mexico.

Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Read More

Pediatr Pulmonol 2019 Jan 27. Epub 2019 Jan 27.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

Objective: Among older infants and children, sleep-disordered breathing (SDB) has negative neurocognitive consequences. We evaluated the frequency and potential impact of SDB among newborns who require intensive care.

Study Design: Term and near-term newborns at risk for seizures underwent 12-h attended polysomnography in the neonatal intensive care unit (NICU). Read More

J Thorac Dis 2018 Dec;10(Suppl 34):S4244-S4252

University Sleep-Wake-Epilepsy Center (SWEZ), Department of NeurologyUniversity Hospital (Inselspital), Bern, Switzerland.

The bidirectional interaction between sleep-disordered breathing (SDB) and stroke has been the subject of many studies. On the one hand, different forms of SDB, and especially obstructive sleep apnea, increase the risk of stroke either directly or indirectly by influencing other known cardiovascular risk factors such as arterial hypertension and arrhythmias. On the other hand, stroke itself can cause either appearance of SDB, aggravate a pre-existing SDB, or trigger a transition from one type of pathological SDB pattern into another. Read More

Chest 2019 Jan 18. Epub 2019 Jan 18.

Sleep Disorders Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland, Baltimore, MD.

Objective: To review systematically the published literature regarding the impact of treatment for OSA on monetized health economic outcomes.

Methods: Customized structured searches were performed in PubMed, Embase (Embase.com), and the Cochrane Central Register of Controlled Trials (Wiley) databases. Read More

Respiration 2019 17;97(3):213-222. Epub 2019 Jan 17.

Laboratoire HP2, INSERM U 1042, Grenoble Alpes University, Grenoble, France.

Background: Despite clinical optimization, many chronic heart failure (CHF) patients remain symptomatic with dyspnea and poor quality of life.

Study Objective: While oxygen therapy is prescribed in severe cases, the actual prevalence of different patterns of hypoxemia is unknown.

Methods: We analyzed 183 stable CHF patients with optimized medical treatment in the "MARS" database. Read More

J Cardiol 2019 Jan 7. Epub 2019 Jan 7.

Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio-renal Medicine, Yokohama, Japan.

Background: Recent pacemakers with transthoracic impedance sensors have a specific algorithm identifying sleep apnea (SA). Our aim was to evaluate the algorithm in Japanese patients.

Methods: Consecutive patients implanted with a pacemaker with sleep apnea monitoring algorithm at our hospital were enrolled prospectively. Read More

J Neurosci 2019 Jan 9. Epub 2019 Jan 9.

Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, 050017, China

The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but the neuronal phenotype and circuit mechanism involved in such a physiological function remain incompletely understood. This study focused on the respiratory role of paired-like homeobox 2b gene (Phox2b)-expressing NTS neurons and sought to determine whether selective stimulation of this set of neurons activates breathing in male mice. A Cre-dependent vector encoding a Gq-coupled human M3 muscarinic receptor (hM3Dq) was microinjected into the NTS of Phox2b-Cre transgenic mice. Read More

J Clin Sleep Med 2019 Jan 15;15(1):119-128. Epub 2019 Jan 15.

Center for Sleep Medicine, Mayo Clinic, Minnesota.

Study Objectives: Adaptive servoventilation (ASV) is the suggested treatment for many forms of central sleep apnea (CSA). We aimed to evaluate the impact of treating CSA with ASV on health care utilization.

Methods: In this population-based study using the Rochester Epidemiology Project database, we identified patients over a 9-year period who were diagnosed with CSA (n = 1,237), commenced ASV therapy, and had ≥ 1 month of clinical data before and after ASV initiation. Read More

J Clin Sleep Med 2019 Jan 15;15(1):65-70. Epub 2019 Jan 15.

Division of Pediatric Neurology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Study Objectives: Patients with alternating hemiplegia of childhood (AHC) experience bouts of hemiplegia and other paroxysmal spells that resolve during sleep. Patients often have multiple comorbidities that could negatively affect sleep, yet sleep quality and sleep pathology in AHC are not well characterized. This study aimed to report sleep data from both polysomnography (PSG) and clinical evaluations in children with AHC. Read More

Am J Respir Crit Care Med 2019 Jan 3. Epub 2019 Jan 3.

Univiversity of Arizona and Southern Arizona VA Health Care System, Tucson, Arizona, United States ;