Search Our Scientific Publications & Authors

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Central sleep apnea is common in heart failure patients. Transvenous phrenic nerve stimulation (TPNS) requires placing a lead to stimulate the phrenic nerve and activate the diaphragm. Data are lacking concerning the safety and efficacy of TPNS in patients with concomitant cardiovascular implantable electronic devices (CIEDs). Read More

Open Access Emerg Med 2020 26;12:173-180. Epub 2020 Jun 26.

Marienkrankenhaus Kassel, Kassel, Germany.

Introduction: Hypercapnia is an indicator of ventilatory exhaustion. There is some disagreement regarding whether hypercapnia is also a predictor of mortality. In this prospective study, we aimed to investigate whether hypercapnia can predict in-hospital and 1-year mortality rates in patients with dyspnea or pulmonary diseases. Read More

Diabetes Ther 2020 Jun 26. Epub 2020 Jun 26.

Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Introduction: Type 2 diabetes mellitus (T2DM) is a major risk factor for the occurrence of cardiovascular diseases. Similar to T2DM, obstructive sleep apnea (OSA) is also known to be a risk factor for cardiovascular diseases. In this analysis, we aimed to systematically compare the post-interventional cardiovascular outcomes observed in patients with T2DM with versus without OSA. Read More

Sleep Breath 2020 Jun 25. Epub 2020 Jun 25.

Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China.

Objective: The purposes of this study were to explore the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on the voice by analyzing the acoustic parameters between patients with OSAHS and those without OSAHS and to compare acoustic analyses performed by two software programs (MDVP and Praat).

Methods: Patients with OSAHS (n = 75) and normal controls (n = 46) were asked to produce a sustained sound of the vowel /i/ and were analyzed with electroglottography (EGG), MDVP, and Praat software. A self-rated scale (Voice Handicap Index, VHI-10) and acoustic parameters were compared. Read More

ESC Heart Fail 2020 Jun 23. Epub 2020 Jun 23.

Department of Cardiology and Pneumology, Germany and German Centre for Cardiovascular Research (DZHK), partner site Göttingen, University of Göttingen Medical Centre, Göttingen, Germany.

Aims: Increased sympathetic activation in patients with heart failure (HF) and sleep-disordered breathing (SDB) provokes cardiac decompensation and protein degradation and could lead to muscle wasting and muscle weakness. The aim of this study was to investigate the differences in body composition, muscle function, and the susceptibility of preclinical congestion among patients with HF and SDB compared with those without SDB.

Methods And Results: We studied 111 outpatients with stable HF who were enrolled into the Studies Investigating Co-morbidities Aggravating Heart Failure. Read More

Obes Surg 2020 Jun 23. Epub 2020 Jun 23.

Department of Surgery, Yotsuya Medical Cube, 7-7 Nibancho, Chiyoda-ku, Tokyo, 102-0084, Japan.

Background: Bariatric surgery is being recognized increasingly as an effective treatment for obesity and related comorbidities. In Japan, the cost of laparoscopic sleeve gastrectomy (LSG) is covered by the national health insurance for adults with a body mass index (BMI) ≥ 35 kg/m and specific comorbidities (type 2 diabetes mellitus (T2DM), hypertension (HT), dyslipidemia (DL), and obstructive sleep apnea syndrome (OSAS)). However, only 0. Read More

ERJ Open Res 2020 Apr 15;6(2). Epub 2020 Jun 15.

Sleep-Wake-Epilepsy Center, Dept of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

Sleep-disordered breathing (SDB) is frequent in patients with acute stroke. Little is known, however about the evolution of SDB after stroke. Most of our knowledge stems from smaller cohort studies applying limited cardiopulmonary sleep recordings or from cross-sectional data collected in different populations. Read More

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Byers Eye Institute, Department of Ophthalmology, Stanford University. Electronic address:

Purpose: To determine the incidence of central serous chorioretinopathy (CSC) stratified by age, sex, and diagnosis with obstructive sleep apnea (OSA), and to determine whether some patients with newly diagnosed CSC may be candidates for OSA evaluation.

Design: Retrospective cohort study.

Methods: We used the IBM Marketscan database to select 59,016,145 commercially-insured patients in the United States between 2007 and 2016. Read More

Life Sci 2020 Jun 19:117994. Epub 2020 Jun 19.

Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei 050017, China. Electronic address:

Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathing. Read More

Int J Cardiol Heart Vasc 2020 Aug 10;29:100548. Epub 2020 Jun 10.

CUF Infante Santo Hospital, CUF Descobertas Hospital, Nova Medical School, Portugal.

Sleep Breath 2020 Jun 19. Epub 2020 Jun 19.

Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.

Purpose: Sleep-disordered breathing (SDB) is associated with hypertension, poor glycemic control and dyslipidemia. Usually, apnoea events tend to be more prominent during rapid eye movement (REM) sleep than non-REM (NREM) sleep. We examined which SDB parameters are associated with blood pressure (BP), HbA1c and lipid profile in patients with type 2 diabetes (T2D). Read More

Mil Med 2020 Jun;185(Supplement_2):21-27

U.S. Army Nurse Corps, JBSA-Fort Sam Houston, TX 78234 Prior Presentation: None.

Patients with the medical diagnosis of obstructive sleep apnea (OSA) and those with undiagnosed OSA have greater chances for adverse events during surgical procedures related to their medical condition. Early identification of at-risk OSA patients can help mitigate associated adverse events. The purpose of this project was to implement a preoperative process to provide early identification of at-risk OSA patients in the preadmission unit, at a large military level I trauma center in central Texas. Read More

Sleep Med 2020 Mar 30;72:93-108. Epub 2020 Mar 30.

Department of Child Health and the Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO, USA.

Over the last decade, emerging studies have related the gut microbiome and gut dysbiosis to sleep and sleep disorders. For example, intermittent hypoxia associated with obstructive sleep apnea was shown to reproducibly alter the gut microbiome. Circadian rhythm disorders (CRD) (eg, shift work disorders, delayed sleep phase syndrome, and advanced sleep phase syndrome) constitute another group of conditions that might be influenced by gut dysbiosis. Read More

J Sleep Res 2020 Jun 18:e13070. Epub 2020 Jun 18.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

Weight loss, continuous positive airway pressure (CPAP) and positional therapy (PT) are important treatments in obstructive sleep apnea (OSA). Although all of these reduce the apnea-hypopnea index (AHI) effectively, the benefits of these treatments have not been thoroughly investigated in a patient-specific manner. Therefore, clinicians do not have objective means to choose an optimal treatment for each patient. Read More

World Neurosurg 2020 Jun 15. Epub 2020 Jun 15.

Department of Orthopaedic Surgery, Toho University Sakura Medical Center, 564-1, Shimoshizu, Sakura City, Chiba, 285-8741, Japan.

Background: Central sleep apnea due to occipitocervical compression myelopathy is an extremely rare condition. Here, we report a case of surgical treatment for central sleep apnea due to occipitocervical compression myelopathy in a patient with Klippel-Feil syndrome.

Case Description: A 60-year-old man had become aware of a gradually progressive clumsiness and gait disturbance without any cause of injury 5 years before. Read More

Retin Cases Brief Rep 2020 Jun 5. Epub 2020 Jun 5.

Stein Eye Institute, 100 Stein Plaza, Los Angeles, California, 90095.

Purpose: Sickle cell trait affects 8% of African Americans. Once believed to represent a benign carrier state, it has been linked to an increased risk of several of the pathological conditions that arise in sickle cell disease in at-risk individuals with hematologic and vascular comorbidities. Macular infarction is a known complication of sickle cell disease, but this report illustrates this unique presentation in a patient with sickle cell trait. Read More

Cornea 2020 Jun 10. Epub 2020 Jun 10.

First Department of Ophthalmology, National and Kapodistrian University of Athens, General Hospital "G. Gennimatas," Athens, Greece.

Purpose: To investigate central endothelial cell density (ECD), morphology, and central corneal thickness (CCT) in patients newly diagnosed with severe obstructive sleep apnea-hypopnea syndrome (OSAHS) and to determine the correlation between these parameters and OSAHS severity.

Methods: This prospective, comparative case series was conducted in a university ophthalmology clinic. In total, 51 patients recently diagnosed with severe OSAHS (apnea-hypopnea index above 30) and a paired, age and sex-matched control group of 44 healthy individuals were enrolled. Read More

Horm Res Paediatr 2020 Jun 12:1-9. Epub 2020 Jun 12.

Pediatric Endocrinology and Diabetology, Children's Hospital, University of Bonn, Bonn, Germany,

Objective: The aim of this study was to consider sleep apnea in Prader-Willi syndrome (PWS) children depending on age at growth hormone (GH) therapy onset.

Study Design: We analyzed longitudinally cardiorespiratory polygraphy of 62 PWS children (aged 0-2.5 years at baseline). Read More

JA Clin Rep 2020 Jun 11;6(1):45. Epub 2020 Jun 11.

Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.

Background: Most children with trisomy 13 display central apnea, and are prone to opioid-induced respiratory depression. We conducted opioid-free anesthesia for a patient with trisomy 13 and obstructive sleep apnea, and safely extubated the patient in the operating room.

Case Presentation: A 27-month-old girl with trisomy 13 underwent tonsillectomy. Read More

Arch Bronconeumol 2020 Jun 8. Epub 2020 Jun 8.

University of Health Science, Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Department of Neurology, Izmir, Turkey.

Objective: To evaluate the impact of the body position on primary central sleep apnea syndrome.

Methods: Fifty-five subjects diagnosed with central sleep apnea (CSA) through polysomnographic examinations were prospectively enrolled in the study. All patients underwent cardiologic and neurologic examinations. Read More

Pediatr Pulmonol 2020 Jun 11. Epub 2020 Jun 11.

Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.

Objectives: Evidence for nocturnal oximetry interpretation in patients with abnormal neuromuscular function is limited. We aimed to compare children with neuromuscular disease (NMD) or Prader-Willi syndrome (PWS) to otherwise healthy subjects with obstructive sleep-disordered breathing (SDB) or without respiratory disorder (controls) regarding nocturnal oximetry parameters.

Methods: We analyzed recordings from children with: (a) NMD; (b) PWS; (c) snoring and adenotonsillar hypertrophy and/or obesity (SDB); and (d) controls. Read More

Clin Res Cardiol 2020 Jun 9. Epub 2020 Jun 9.

Department of Internal Medicine II, University Medical Centre Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Obejctive: Obstructive sleep apnoea (OSA) increases left ventricular transmural pressure more than central sleep apnoea (CSA) owing to negative intrathoracic pressure swings. We tested the hypothesis that the severity of OSA, and not CSA, is therefore associated with spheric cardiac remodelling after acute myocardial infarction.

Methods: This sub-analysis of a prospective observational study included 24 patients with acute myocardial infarction who underwent primary percutaneous coronary intervention. Read More

Clin Diabetes Endocrinol 2020 5;6:10. Epub 2020 Jun 5.

Department of Endocrinology, Room no. 419, 4th floor, College building, Topiwala National Medical College and Bai Yamunabai Laxman (B.Y.L.) Nair Charitable Hospital, A.L. Nair Road, Mumbai Central, Mumbai, Maharashtra 400008 India.

Background: Obstructive sleep apnea syndrome (OSAS) in association with Type 2 Diabetes Mellitus (DM) may result in increased glycemic variability affecting the glycemic control and hence increasing the risk of complications associated with diabetes. We decided to assess the Glycemic Variability (GV) in patients with type 2 diabetes with OSAS and in controls. We also correlated the respiratory disturbance indices with glycemic variability indices. Read More

J Curr Ophthalmol 2020 Jan-Mar;32(1):19-25. Epub 2020 Mar 23.

Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: To evaluate the multiple pretreatment characteristics and topographic factors of keratoconus (KC) patients and their relationship to clinical outcomes of corneal collagen cross-linking (CXL).

Methods: In this prospective study, 61 patients (106 eyes) with KC as candidates for CXL were included. Demographic data including age, sex, place of birth and residence, atopic constitution, family history, rubbing history, sleep apnea, and blood group were collected via a structured checklist. Read More

J Clin Neurophysiol 2020 May 26. Epub 2020 May 26.

Sleep and Disorders Unit, Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Purpose: Cyclic alternating pattern (CAP) is known to increase in many conditions of sleep disruption and sleep disorders, including obstructive sleep apnea syndrome and periodic limb movements in sleep (PLMS). Periodic limb movements in sleep associated with obstructive sleep apnea syndrome may vanish after positive airway pressure treatment, may persist, or emerge at treatment night. Here, the authors aimed to investigate the underlying pathophysiology of nonvanishing, vanishing, or newly emergent PLMS. Read More

J Appl Physiol (1985) 2020 Jul 5;129(1):49-57. Epub 2020 Jun 5.

Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, Iowa.

It is widely agreed that breathing is subject to circadian regulation. Circadian differences in respiratory physiology significantly impact a number of diseases including sleep apnea, asthma, and seizure-induced death. The effect of time of day on breathing has been previously characterized; however, an endogenous free-running respiratory rhythm in mammals has not previously been described. Read More

eNeuro 2020 May/Jun;7(3). Epub 2020 Jun 22.

Institute for Integrative Physiology, The University of Chicago, Chicago, IL 60637

Sleep apnea causes cognitive deficits and is associated with several neurologic diseases. Intermittent hypoxia (IH) is recognized as a principal mediator of pathophysiology associated with sleep apnea, yet the basis by which IH contributes to impaired cognition remains poorly defined. Using a mouse model exposed to IH, this study examines how the transcription factor, hypoxia inducible factor 1a (HIF1a), contributes to disrupted synaptic physiology and spatial memory. Read More

J Int Med Res 2020 Jun;48(6):300060520926065

Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, China.

Objectives: Migration of macrophages and atherosclerosis result in various diseases, including coronary heart disease. This study aimed to clarify the roles that ghrelin and Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) play in migration of macrophages under chronic intermittent hypoxia (CIH).

Methods: A rat model of CIH was constructed and changes in ghrelin and ROCK2 protein expression were measured by western blot assay. Read More

Sleep Med 2020 Jul 5;71:35-36. Epub 2020 May 5.

Division of Cardiology, University of Washington, Seattle, WA, USA.

Sleep Breath 2020 May 29. Epub 2020 May 29.

Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, PO Box 263, HUS, 00029, Helsinki, Finland.

Purpose: We have previously demonstrated that dogs can be trained to distinguish the urine of patients with obstructive sleep apnea (OSA) from that of healthy controls based on olfaction. Encouraged by these promising results, we wanted to investigate if a detection dog could work as a screening tool for OSA. The objective of this study was to prospectively assess the dogs' ability to identify sleep apnea in patients with OSA suspicion. Read More

J Electrocardiol 2020 May 12;61:10-17. Epub 2020 May 12.

University of Hawai'i at Mānoa, Department of Geriatric Medicine, John A. Burns School of Medicine, 347 N Kuakini St, Honolulu, HI, USA; Kuakini Medical Center, 347 N Kuakini St, Honolulu, HI, USA. Electronic address:

Introduction: While several studies have indicated that central sleep apnea (CSA) is associated with atrial fibrillation and atrial flutter (AF) in older populations, few studies have focused on older Asian populations.

Methods: We conducted a cross- sectional analysis using data from the 1999-2000, 7th exam cycle of the Kuakini Honolulu-Asia Aging Study. Participants were 718 Japanese-American men between 79 and 97 years old, who had overnight polysomnography. Read More

Pediatrics 2020 Jun;145(6)

Department of Pediatrics, University of California, San Diego and Rady Children's Hospital, San Diego, California.

Achondroplasia is the most common short-stature skeletal dysplasia, additionally marked by rhizomelia, macrocephaly, midface hypoplasia, and normal cognition. Potential medical complications associated with achondroplasia include lower extremity long bone bowing, middle-ear dysfunction, obstructive sleep apnea, and, more rarely, cervicomedullary compression, hydrocephalus, thoracolumbar kyphosis, and central sleep apnea. This is the second revision to the original 1995 health supervision guidance from the American Academy of Pediatrics for caring for patients with achondroplasia. Read More

J Interv Card Electrophysiol 2020 May 22. Epub 2020 May 22.

The Kansas City Heart Rhythm Institute (KCHRI) & Research Foundation, Overland Park Regional Medical Center, HCA Mid-West, 5100 West 110th Street, Suite 200, Overland Park, KS, 66221, USA.

Purpose: Phrenic and hypoglossal nerve pacing therapies have shown benefit in sleep apnea. We sought to analyze the role of pacing therapies in sleep apnea and their impact on heart failure.

Methods: A comprehensive literature search in PubMed and Google Scholar from inception to August 5, 2019, was performed. Read More

J Med Internet Res 2020 May 22;22(5):e17252. Epub 2020 May 22.

Kite Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.

Background: Sleep apnea is a respiratory disorder characterized by an intermittent reduction (hypopnea) or cessation (apnea) of breathing during sleep. Depending on the presence of a breathing effort, sleep apnea is divided into obstructive sleep apnea (OSA) and central sleep apnea (CSA) based on the different pathologies involved. If the majority of apneas in a person are obstructive, they will be diagnosed as OSA or otherwise as CSA. Read More

Am J Cardiol 2020 Jul 24;127:73-83. Epub 2020 Apr 24.

University of California Irvine Sleep Disorders Center, Orange, California.

Patients with heart failure with reduced ejection fraction and predominant central sleep apnea pose treatment challenges. A system review and meta-analysis of randomized controlled trials (RCTs) were undertaken. Electronic searches of digital repositories, journals, specialty society and manufacturer websites, manual searches of reference sections of RCTs, and published clinical guidelines were performed. Read More

Front Neurosci 2020 28;14:382. Epub 2020 Apr 28.

Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia - Okanagan, Kelowna, BC, Canada.

Components of the renin-angiotensin system (RAS) situated within the carotid body or central nervous system may promote hypoxia-induced chemoreceptor reflex sensitization or central sleep apnea (CSA). We determined if losartan, an angiotensin-II type-I receptor (ATR) antagonist, would attenuate chemoreceptor reflex sensitivity before or after 8 h of nocturnal hypoxia, and consequently CSA severity. In a double-blind, randomized, placebo-controlled, crossover protocol, 14 men (age: 25 ± 2 years; BMI: 24. Read More

Sleep Med Clin 2020 Jun;15(2):241-250

Department of Orthodontics, National Dental Centre Singapore, 5 Second Hospital Avenue, Singapore 168938, Singapore.

Obstructive sleep apnea (OSA) is a multifactorial condition, and an interdisciplinary approach to diagnosis forms the basis for effective treatment planning. Craniofacial structure and attached soft tissues and muscles play a central role in OSA. Evidence-based studies demonstrate the effectiveness of oral appliances for mandibular advancement and tongue stabilization in managing OSA, and current clinical standards of practice recommend the use of oral appliances to treat OSA when patients cannot tolerate continuous positive airway pressure (CPAP). Read More

Medicine (Baltimore) 2020 May;99(19):e20055

Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining.

Introduction: Sleep apnea-hypopnea syndrome (SAHS) is a multifactorial disease characterized by recurrent hypopnea or respiratory interruption during sleep, which causes intermittent hypoxemia, hypercapnia, and sleep structure disturbances. An association between ankylosing spondylitis (AS) and the type of SAHS has rarely been reported in the literature. Here, we present a case of SAHS in a patient with AS and discuss the possible mechanism underlying the type of SAHS. Read More

J Obes Metab Syndr 2020 Jun;29(2):99-109

Division of Endocrinology and Metabolism, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.

Obesity is a serious and growing worldwide health challenge associated with type 2 diabetes mellitus, cardiovascular disease, osteoarthritis, some cancers, sleep apnea, asthma, and nonalcoholic fatty liver. The Korean Society for the Study of Obesity recommends that pharmacotherapy should be considered when intensive lifestyle modifications fail to achieve a weight reduction in obese patients with a body mass index ≥25 kg/m. Long-term medications for obesity have traditionally fallen into two major categories: centrally acting anorexiant medications and peripherally acting medications, such as orlistat. Read More

Arch Phys Med Rehabil 2020 May 3. Epub 2020 May 3.

Health Economics Resource Center (HERC), Palo Alto VA Health Care System, Palo Alto, CA: Division of Internal Medicine, Medical University of South Carolina, Charleston, SC.

Objective: To describe the cost-benefit of four different approaches to screening for sleep apnea in a cohort of participants with moderate to severe TBI receiving inpatient rehabilitation from the payor's perspective.

Design: A cost-benefit analysis of phased approaches to sleep apnea diagnosis.

Setting: Six TBI Model System Inpatient Rehabilitation Centers PARTICIPANTS: Trial data from 214 participants were used in analyses (mean age 44 [SD 18], 82% male, 75% white, with primarily motor-vehicle related injury [44%] and falls [33%] with a sample mean emergency department Glasgow Coma Scale of 8 (SD 5). Read More

ORL J Otorhinolaryngol Relat Spec 2020 May 6:1-8. Epub 2020 May 6.

Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.

Background: A new transoral tongue base surgical procedure for the treatment of snoring and obstructive sleep apnea (OSA) is described. It is named "Robo-Cob" technique because it is similar to transoral robotic surgery (TORS) but it is performed by means of coblation technology in order to resect the tongue base in countries where TORS is not an available option for such benign conditions.

Methods: In this prospective, randomized, controlled trial, the new Robo-Cob technique was carried out in 25 adult OSA patients with confirmed tongue base hypertrophy at preoperative drug-induced sedation endoscopy. Read More

Sleep 2020 May 5. Epub 2020 May 5.

Department of Medicine and Clinical Research Core, Weill Cornell Medicine - Qatar, Qatar Foundation - Education City, Doha, Qatar.

Obstructive sleep apnea (OSA) is characterized by recurrent partial to complete upper airway obstructions during sleep, leading to repetitive arousals and oxygen desaturations. Although many OSA biomarkers have been reported individually, only a small subset have been validated through both cross-sectional and intervention studies. Here, we used a highly multiplexed aptamer array (SomaScan) for proteomic analysis of serum samples from 713 individuals in the Stanford Sleep Cohort, a patient-based registry. Read More

Otolaryngol Head Neck Surg 2020 May 5:194599820917631. Epub 2020 May 5.

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Objective: To evaluate the treatment efficacy of transcutaneous electrical nerve stimulation (TENS) in patients with obstructive sleep apnea (OSA).

Data Sources: Primary studies were identified though PubMed, Scopus, OVID, and Cochrane Library.

Review Methods: Systematic review was conducted by querying databases for articles published through July 2019. Read More

Front Med (Lausanne) 2020 17;7:132. Epub 2020 Apr 17.

Department of Otolaryngology, The University of Tokyo, Tokyo, Japan.

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder. Since patients with MSA often have sleep-related respiratory disorders including upper-airway obstruction and/or central sleep disturbance, appropriate evaluation of the upper airway especially during sleep may be indispensable. Fiberoptic laryngoscopy during diazepam-induced sleep has been reported for upper-airway obstruction verification. Read More

J Pediatr Genet 2020 Jun 21;9(2):132-136. Epub 2019 Oct 21.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Sleep-disordered breathing (SDB) is common in children, especially in those with congenital or genetic diseases. The factors involved include obstructive sleep apnea, disrupted rapid eye movement sleep, and central hypoventilation. Diagnosing and treating SDB in these children have a positive impact on the quality of life of them and their families, reducing the risk of both further impairment of cognitive abilities and cardiopulmonary complications. Read More

Am J Physiol Heart Circ Physiol 2020 05 24;318(5):H1325-H1336. Epub 2020 Apr 24.

Centro de Fisiología Celular e Integrativa, Facultad de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

Unilateral carotid body denervation has been proposed as treatment for sympathetic-related human diseases such as systolic heart failure, hypertension, obstructive sleep apnea, and cardiometabolic diseases. The long-term therapeutic effects of carotid body removal will be maintained if the remnant "buffer nerves," that is, the contralateral carotid nerve and the aortic nerves that innervate second-order neurons at the solitary tract nuclei (NTS), do not modify their contributions to the cardiovascular chemoreflexes. Here, we studied the cardiovascular chemoreflexes 1 mo after unilateral carotid body denervation either by excision of the petrosal ganglion (petrosal ganglionectomy, which eliminates central carotid afferents) or exeresis of a segment of one carotid nerve (carotid neurectomy, which preserves central afferents). Read More

Int J Cardiol 2020 Apr 2. Epub 2020 Apr 2.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy; Cardiology and Cardiovascular Medicine Division, Fondazione Toscana Gabriele Monasterio, National Research Council, CNR-Regione Toscana, Pisa, Italy.

Background: In contrast to continuous positive airway pressure (CPAP), the use of adaptive servo-ventilation (ASV) for treatment of central sleep apnoea (CSA) was associated with increased mortality in patients with chronic systolic heart failure (CHF). In order to characterize the interplay between sleep-disordered breathing, CHF and sympathovagal balance (SVB) this study investigated the effect of nocturnal CPAP and ASV on SVB in CSA patients with or without CHF.

Methods: Thirty-seven patients with ongoing positive airway pressure therapy (CPAP or ASV) for CSA (17 patients with systolic CHF - left ventricular ejection fraction <50% - and 20 patients with CSA but no CHF) underwent evaluation of SVB (spectral analysis of heart rate -HRV- and diastolic blood pressure variability) during full nocturnal polysomnography. Read More

Front Med (Lausanne) 2020 3;7:105. Epub 2020 Apr 3.

Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Use of adaptive servo-ventilation (ASV) has been questioned in patients with central sleep apnea (CSA) and chronic heart failure (CHF). This study aims to detail the present use of ASV in clinical practice. Descriptive, cross-sectional, multicentric study of patients undergoing long term (≥3 months) ASV in the Cantons of Geneva or Vaud (1,288,378 inhabitants) followed by public or private hospitals, private practitioners and/or home care providers. Read More

J Oral Rehabil 2020 Jul 11;47(7):889-901. Epub 2020 Jun 11.

Department of Stomatology, Kunming Yan'an Hospital, Kunming City, China.

Objective: This study was conducted to evaluate the changes of temporomandibular joints (TMJs) through magnetic resonance imaging (MRI) scanning and the electrical changes in mandibular movement and masticatory muscle surface of mild-to-moderate obstructive sleep apnoea-hypopnoea syndrome (OSAHS) patients before and after treatment with mandibular advancement device (MAD).

Methods: This was a single-centre, prospective study recruiting OSAHS patients undergoing treatment with MAD in Department of Stomatology, Yannan Hospital, Kunming, China. Patients were recruited from February 2015 to October 2015, and TMJ changes were observed in MRI scanning before and after 18 months of treatment with MAD in cohort 1. Read More