Clin Liver Dis 2022 05 1;26(2):149-164. Epub 2022 Apr 1.
Department of Nephrology, Ochsner Health, 1514 Jefferson Highway, Clinic Tower 5th, Floor, Room 5E328, New Orleans, LA 70121, USA; Ochsner Clinical School/The University of Queensland, Brisbane, Queensland, Australia. Electronic address: https://twitter.com/VelezNephHepato.
Hyponatremia is the most common electrolyte disorder encountered in clinical practice, and it is a common complication of cirrhosis reflecting an increase in nonosmotic secretion of arginine vasopressin as a result of of the circulatory dysfunction that is characteristic of advanced liver disease. Hyponatremia in cirrhosis has been associated with poor clinical outcomes including increased risk of morbidity and mortality, poor quality of life, and heightened health care utilization. Despite this, the treatment of hyponatremia in cirrhosis remains challenging as conventional therapies such as fluid restriction are frequently ineffective. Read More