1,093 results match your criteria Central Pontine Myelinolysis


[A case of liver cirrhosis with central pontine myelinolysis].

Authors:
X Li

Zhonghua Gan Zang Bing Za Zhi 2018 Oct;26(10):784-785

Department of Gastroenterology, The People's Hospital of Shanxi Province, Taiyuan 030012, China.

View Article

Download full-text PDF

Source
October 2018

Normal Correction of Sodium Leading to Central Pontine Demyelinosis: A Rare Occurrence.

Cureus 2018 Sep 4;10(9):e3252. Epub 2018 Sep 4.

Internal Medicine, Shifa College of Medicine, Rawalpindi, PAK.

Central pontine myelinolysis is a rare condition arising from the myelinolysis of white matter tracts in the pons, most commonly in response to iatrogenic hypertonic stress caused by the rapid correction of hyponatremia. Here, we present an interesting case of central pontine myelinolysis subsequent to normal saline infusion despite strict adherence to the guideline protocol. Read More

View Article

Download full-text PDF

Source
https://www.cureus.com/articles/14693-normal-correction-of-s
Publisher Site
http://dx.doi.org/10.7759/cureus.3252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217865PMC
September 2018
3 Reads

Treatment response in osmotic demyelination syndrome presenting as severe parkinsonism, ptosis and gaze palsy.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Osmotic demyelination syndrome commonly affects the pons and infrequently involves the extrapontine region. We report a patient with severe hyponatraemia who developed osmotic demyelination syndrome as a consequence of rapid sodium correction. The condition manifested as acute severe parkinsonism, bilateral ptosis and gaze impairment. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22575
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-225751DOI Listing
October 2018
12 Reads

Extrapontine Myelinolysis and Reversible Parkinsonism After Hyponatremia Correction in a Case of Pituitary Adenoma: Hypopituitarism as a Predisposition for Osmotic Demyelination.

World Neurosurg 2018 Oct 25;118:304-310. Epub 2018 Jul 25.

Department of Neurosurgery, Ramaiah Institute of Neurosciences, Ramaiah Medical College and Hospitals, Bangalore, India.

Background: Osmotic demyelination syndrome commonly follows rapid correction of hyponatremia. Although pons is a common location, extrapontine locations, such as striatum and thalamus, have been reported.

Case Description: A 48-year-old woman presented with masked facies, shuffling gait, and pill-rolling tremors suggestive of acute-onset parkinsonism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.07.115DOI Listing
October 2018
4 Reads
2.420 Impact Factor

[Disturbances of Sodium Homeostasis].

Authors:
Florian Dresely

Anasthesiol Intensivmed Notfallmed Schmerzther 2018 Jul 23;53(7-08):492-502. Epub 2018 Jul 23.

Sodium is the most important osmotically effective cation in the extracellular space and very important for the water balance of the organism. Disturbances in the sodium homeostasis are therefore usually closely associated with disturbances in the water balance. The most important organs involved in the regulation of the sodium homeostasis are the kidneys and the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0043-121662DOI Listing
July 2018
9 Reads

Central Pontine Myelinolysis in Pediatric Diabetic Ketoacidosis.

Case Rep Crit Care 2018 4;2018:4273971. Epub 2018 Jun 4.

Department of Pediatric Critical Care, Kapiolani Medical Center for Women & Children, USA.

Central pontine myelinolysis (CPM) is rarely reported in pediatric patients with diabetic ketoacidosis (DKA). We report this case of a 16-year-old female with new onset diabetes presenting with DKA, who received aggressive fluid resuscitation and sodium bicarbonate in the emergency department. Later she developed altered mental status concerning for cerebral edema and received hyperosmolar therapy with only transient improvement. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/cricc/2018/4273971/
Publisher Site
http://dx.doi.org/10.1155/2018/4273971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008881PMC
June 2018
25 Reads

Astroglial Modulation of Hydromineral Balance and Cerebral Edema.

Front Mol Neurosci 2018 12;11:204. Epub 2018 Jun 12.

Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, United States.

Maintenance of hydromineral balance (HB) is an essential condition for life activity at cellular, tissue, organ and system levels. This activity has been considered as a function of the osmotic regulatory system that focuses on hypothalamic vasopressin (VP) neurons, which can reflexively release VP into the brain and blood to meet the demand of HB. Recently, astrocytes have emerged as an essential component of the osmotic regulatory system in addition to functioning as a regulator of the HB at cellular and tissue levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007284PMC

Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia.

Clin J Am Soc Nephrol 2018 Jul 5;13(7):984-992. Epub 2018 Jun 5.

Department of Nephrology, Geisinger Medical Center, Danville, Pennsylvania; and

Background And Objectives: Rapid correction of severe hyponatremia can result in serious neurologic complications, including osmotic demyelination. Few data exist on incidence and risk factors of rapid correction or osmotic demyelination.

Design, Setting, Participants, & Measurements: In a retrospective cohort of 1490 patients admitted with serum sodium <120 mEq/L to seven hospitals in the Geisinger Health System from 2001 to 2017, we examined the incidence and risk factors of rapid correction and osmotic demyelination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.13061117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032596PMC
July 2018
7 Reads

Desmopressin-Induced Severe Hyponatremia with Central Pontine Myelinolysis: A Case Report.

Drug Saf Case Rep 2018 Apr 25;5(1):19. Epub 2018 Apr 25.

Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, 462 First Avenue, NBV 7N24, New York, NY, 10016, USA.

Desmopressin, a synthetic vasopressin analog, is used to treat central diabetes insipidus, hemostatic disorders such as von Willebrand's disease, and nocturnal enuresis. We present the case of a 69-year-old man who developed severe hyponatremia during treatment with intranasal desmopressin at 10 µg twice daily for chronic polyuria and nocturia thought to be due to central diabetes insipidus. After 5 months of therapy, the patient noticed progressive fatigue, anorexia, dizziness, weakness, light-headedness, decreased concentration, and new-onset falls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40800-018-0084-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918148PMC
April 2018
2 Reads

Therapeutic Effect of Steroids in Osmotic Demyelination of Infancy.

Authors:
Lalit R Bansal

Child Neurol Open 2018 15;5:2329048X18770576. Epub 2018 Apr 15.

Division of Neurology, Children's Mercy Hospital, Kansas City, MO, USA.

An 11-month-old male presented with acute gastroenteritis, seizures, and altered mental status. Laboratory workup revealed serum sodium of 177 mmol/L. Magnetic resonance imaging of the brain showed reduced diffusion in the supratentorial white matter, T2 hyperintensities in the left central pons and midbrain, subacute stroke in the right occipital lobe, and bilateral cerebellar hemorrhagic infarcts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2329048X18770576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903026PMC
April 2018
1 Read

Abrus Precatorius Poisoning and Central Pontine Myelinolysis.

J Pediatr Neurosci 2017 Oct-Dec;12(4):353-355

Department of Pediatric Medicine, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

Accidental poisoning with Abrus precatorius (AP) can rarely produce neurological complication due to its toxic principle "Abrin". The authors report such a case in a 2-year old child, who subsequently developed central pontine myelinolysis, an association, to the best of the author's knowledge, has never been reported in literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jpn.JPN_84_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890557PMC

Paroxysmal painful spasms associated with central pontine myelinolisis in the context of nonketotic hyperglycemia.

J Neurol Sci 2018 May 5;388:37-39. Epub 2018 Mar 5.

Unit of Neurology, Misericordia Hospital, Grosseto, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2018.03.005DOI Listing
May 2018
3 Reads

Imaging of neurovascular emergencies in pregnancy and puerperium.

Emerg Radiol 2018 Aug 6;25(4):435-440. Epub 2018 Apr 6.

Department of Neuroimaging and Interventional Radiology, NIMHANS, Bangalore, 560029, India.

Acute neurovascular events, though rare, can complicate pregnancy and postpartum period. It is important to be aware of these clinical conditions for reducing maternal and fetal morbidity and mortality. In this review, we present a few important neurovascular emergencies and their imaging manifestations by various imaging modalities-computed tomography (CT), magnetic resonance imaging (MRI), and digital subtraction angiography (DSA)-which presented at our institution in the peripartum period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10140-018-1600-4DOI Listing
August 2018
2 Reads

Tongue fasciculations with denervation pattern in osmotic demyelination syndrome: a case report of diagnostic dilemma.

BMC Res Notes 2018 Mar 14;11(1):177. Epub 2018 Mar 14.

National Hospital, Colombo, Sri Lanka.

Background: The pathogenesis of osmotic demyelination syndrome is not completely understood and usually occurs with severe and prolonged hyponatremia, particularly with rapid correction. It can occur even in normonatremic patients, especially who have risk factors like alcoholism, malnutrition and liver disease. Bilateral tongue fasciculations with denervation pattern in electromyogram is a manifestation of damage to the hypoglossal nucleus or hypoglossal nerves. Read More

View Article

Download full-text PDF

Source
https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
Publisher Site
http://dx.doi.org/10.1186/s13104-018-3287-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853098PMC
March 2018
5 Reads

Hyperglycemia-related central pontine demyelinization after a binge-eating attack in a patient with type-2 diabetes: a case report.

BMC Endocr Disord 2018 Mar 12;18(1):18. Epub 2018 Mar 12.

Department of Internal Medicine II, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.

Background: Here, we report a case of central pontine demyelinization in a type-2 diabetes patient with hyperglycemia after a binge-eating attack in the absence of a relevant hyponatremia.

Case Presentation: A 55-year-old, male type-2 diabetic patient with liver cirrhosis stage Child-Pugh B was admitted due to dysmetria of his right arm, gait disturbance, dizziness, vertigo, and polyuria, polydipsia after a binge-eating attack of sweets (a whole fruit cake and 2 Liters of soft drinks). A recently initiated insulin therapy had been discontinued for 8 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12902-018-0245-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848589PMC
March 2018
7 Reads

Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis.

Medicine (Baltimore) 2018 Feb;97(8):e9878

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Rationale: Marchiafava-Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000009878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841975PMC
February 2018
8 Reads

Latent systemic lupus erythematosus presenting with hypokalaemic quadriparesis and central pontine myelinolysis.

Neurol Sci 2018 06 10;39(6):1133-1136. Epub 2018 Feb 10.

Dr. S.N. Medical College Jodhpur, Jodhpur, Rajasthan, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-017-3238-5DOI Listing
June 2018
2 Reads

Osmotic Demyelination Unrelated to Hyponatremia.

Am J Kidney Dis 2018 Mar 23;71(3):436-440. Epub 2017 Dec 23.

Division of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX; Division of Nephrology, Department of Medicine, Methodist Hospital, Houston, TX; Renal Section, Veterans Affairs Medical Center, Houston, TX.

Osmotic demyelination unrelated to hyponatremia is rarely reported. We present a case of osmotic demyelination in a patient with hypernatremia in the absence of preceding hyponatremia and review previously reported cases of osmotic demyelination in nonhyponatremic patients. We conclude that a rapid increase in serum sodium concentration and plasma tonicity even in the absence of preceding hyponatremia may surpass the brain's capacity for adaptation to hypertonicity and lead to osmotic demyelination in predisposed individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.ajkd.2017.10.010DOI Listing
March 2018
14 Reads

Acute Onset of Parkinsonism an End-Stage Renal Disease Patient.

Acta Neurol Taiwan 2017 Jun;26(2):64-67

Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Purpose: The osmotic demyelination syndrome (ODS) has been identified as a neurological complication of the rapid correction of hyponatremia. In recent years, however, various medical conditions have been associated with the development of ODS, irrelevant to changes in serum sodium. We present a rare case of a eunatremic patient who developed ODS with manifestation of parkinsonism. Read More

View Article

Download full-text PDF

Source
June 2017
3 Reads

Utility of Tolvaptan in the Perioperative Management of Severe Hyponatremia During Liver Transplantation: A Case Report.

Transplant Proc 2017 Dec;49(10):2399-2401

Department of Pulmonary and Critical Care, Emory University, Atlanta, Georgia; Department of Transplant Hepatology, Emory University, Atlanta, Georgia. Electronic address:

Severe hyponatremia can complicate the pretransplantation management of patients with decompensated cirrhosis while they await liver transplantation. Before the liver transplant, it is critical to correct severe hyponatremia to an appropriate level to reduce the risks of perioperative complications such as central pontine myelinolysis, cerebral edema, and seizures. Vasopressin receptor antagonists, and in particular tolvaptan, offer a therapeutic modality that can correct severe refractory hyponatremia in a timely and predictable manner before liver transplantation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00411345173066
Publisher Site
http://dx.doi.org/10.1016/j.transproceed.2017.09.011DOI Listing
December 2017
4 Reads

A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination.

Forensic Sci Med Pathol 2018 03 25;14(1):106-108. Epub 2017 Nov 25.

Department of Neuropathology, North Bristol NHS Trust, Bristol, UK.

Central pontine myelinolysis (CPM) is a neurological demyelinating disease of the pons. Although usually associated with rapid correction of hyponatremia, CPM may occur despite normonatremia, is often associated with chronic alcoholism and may be asymptomatic. Histological confirmation of asymptomatic CPM is rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12024-017-9933-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830465PMC
March 2018
9 Reads

Subacute central pontine myelinolysis secondary to hyperglycaemia.

Neurologia 2017 Nov 20. Epub 2017 Nov 20.

Departamento Neurología, Hospital Universitario de Getafe, Getafe, Madrid, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nrl.2017.09.009DOI Listing
November 2017
1 Read

Localized Pontine Uptake in Fluorine-18-Fuorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Case of Hyponatremia: A Case Report and Review of Literature.

Indian J Nucl Med 2017 Oct-Dec;32(4):333-335

Department of Nuclear Medicine, Apollo Hospitals, Chennai, Tamil Nadu, India.

A rare acquired demyelinating lesion of the pons central pontine myelinolysis (CPM) typically occurs after rapid correction of hyponatremia. There is disruption of blood-brain barrier due to osmotic stress allowing access for inflammatory mediators in extravascular brain tissue, which most likely attracts glial cells of the brain, attracts macrophages, and activates astrocytes. We present a case of female with a known history of inflammatory bowel disease who presented with altered sensorium and hyponatremia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijnm.IJNM_59_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672756PMC
November 2017
3 Reads

Central Pontine Myelinolysis After Living-Donor Liver Transplant: A Report of 2 Cases.

Exp Clin Transplant 2017 Nov 15. Epub 2017 Nov 15.

From the Department of Nursing, Changhua Christian Hospital, Changhua, Taiwan.

Here, we present 2 patients who developed central pontine myelinolysis after living-donor liver transplant. Both patients had abnormal sodium level before living-donor liver transplant. Patient 1 presented with severe hyponatremia on admission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6002/ect.2017.0060DOI Listing
November 2017
4 Reads

Is Central Pontine Myelinolysis Reversible?

WMJ 2016 12;115(6):326-8

Central pontine myelinolysis (CPM) is a rare phenomenon that causes significant morbidity and mortality. Active therapeutic interventions for CPM can have a positive impact on recovery and overall prognosis. This case represents a 34-year-old white man with a chronic history of alcohol abuse who had Parkinsonian symptoms 13 days after rapid correction of his serum sodium in the hospital. Read More

View Article

Download full-text PDF

Source
December 2016
4 Reads

Alcohol-related diseases.

Handb Clin Neurol 2017 ;145:175-180

Department of Forensic Medicine, University of Rostock, Rostock, Germany.

Alcohol abuse and dependence are serious medical and economic problems in Western countries. Brain changes encountered in alcoholism are manifold and encompass brain atrophy, selective neuronal loss, astroglial, and microglial changes. Alcohol-related disorders are complex multifactorial disorders where the interaction of multiple genes and environment plays an important role in the pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-802395-2.00013-4DOI Listing
January 2018
3 Reads

Atypical presentation of central pontine myelinolysis in hyperglycemia.

Endocrinol Diabetes Metab Case Rep 2017 4;2017. Epub 2017 Sep 4.

Endocrinology, Guthrie Robert Packer Hospital, Sayre, Pennsylvania, USA.

Central pontine myelinolysis (CPM) usually occurs with rapid correction of severe chronic hyponatremia. Despite the pronounced fluctuations in serum osmolality, CPM is rarely seen in diabetics. This is a case report of CPM associated with hyperglycemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EDM-17-0064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592705PMC
September 2017
52 Reads

Central pontine myelinolysis and poorly controlled diabetes: MRI's hints for pathogenesis.

Neurol Sci 2018 01 15;39(1):193-195. Epub 2017 Sep 15.

Department of Biomedical, Metabolic, and Neural Sciences, N.O.C.S.A.E. Hospital, AOU Modena, University of Modena and Reggio Emilia, 41100, Modena, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-017-3117-0DOI Listing
January 2018
3 Reads

Letter to the Editor: Presentation of extrapontine myelinolysis associated with hypernatremia in an infant: a case report.

Childs Nerv Syst 2017 11 13;33(11):1881-1882. Epub 2017 Sep 13.

Department of Neurosurgery, Indiana University School of Medicine and Goodman Campbell Brain and Spine, Indianapolis, IN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-017-3574-zDOI Listing
November 2017
11 Reads

Osmotic Demyelination Syndrome Revisited: Review With Neuroimaging.

J La State Med Soc 2017 Jul-Aug;169(4):89-93. Epub 2017 Aug 28.

Department of Radiology, Tulane University Health Sciences Center - New Orleans, LA.

Osmotic demyelination syndrome (ODS) is a general term that has become commonplace in the practice of medicine, encompassing both central pontine myelinolysis and extrapontine myelinolysis. Historically ODS arises as a serious complication of rapid correction of hyponatremia, yet its manifestations seem to be influenced by a multifactorial process. Further understanding of this rare demyelinating disease has elucidated the significant role of other electrolyte disturbances and the presence of chronic comorbidities as disease risk factors. Read More

View Article

Download full-text PDF

Source
March 2018
36 Reads

Wilson's disease presenting as central pontine myelinolysis.

Neurol Sci 2017 12 7;38(12):2223-2225. Epub 2017 Aug 7.

Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Niyayesh St, Sattarkhan Ave, Tehran, 1445613131, Iran.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-017-3064-9DOI Listing
December 2017
1 Read

Acute necrotic pancreatitis: A rare and not always fatal cause of central pontine myelinolysis.

Presse Med 2017 Oct 27;46(10):968-970. Epub 2017 Jul 27.

Rouen university hospital, department of anesthesiology and intensive care, 76031 Rouen, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lpm.2017.06.011DOI Listing
October 2017
4 Reads

Demyelinating diseases as a result of cerebral edema?

Med Hypotheses 2017 Jul 10;104:10-14. Epub 2017 May 10.

Helios-Klinikum Pirna, Struppener Straβe 13, D-01796 Pirna, Saxony, Germany. Electronic address:

Due to the elastic properties of the human organs, tissue edema causes an increased tissue pressure. This phenomenon leads to a reduction of blood circulation or ischemia, and thus leads to the hypothesis that tissue edema can be the cause of demyelinating lesions. Even though brain edema occurs in the whole brain, the authors assume that the characteristically focal appearance of demyelinated lesions, for instance of multiple sclerosis plaques, are attributable to anatomical and structural characteristics of the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2017.05.010DOI Listing
July 2017
9 Reads

Central pontine myelinolysis in a type 1 diabetes patient with chronic hepatitis.

Rev Neurol (Paris) 2018 Jan - Feb;174(1-2):66-67. Epub 2017 Jun 2.

Department of internal medicine, university hospital and medical school of Oran, centre hospitalier universitaire d'Oran, 76, boulevard du Dr-Benzerdjeb, 31000 Oran, Algeria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurol.2017.05.014DOI Listing
November 2018
2 Reads

Clinical Reasoning: A 27-year-old man with acute-onset ataxia.

Neurology 2017 05;88(22):e207-e211

From the Department of Neurology (J.R.), University of Rochester Medical Center; and University of Rochester School of Medicine (M.W.), NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003986DOI Listing
May 2017
2 Reads

Osmotic demyelination syndrome in type 1 diabetes in the absence of dyselectrolytaemia: an overlooked complication?

BMJ Case Rep 2017 May 12;2017. Epub 2017 May 12.

Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India.

Central pontine myelinolysis (CPM) is a demyelinating disorder of central nervous system which involves central portion of the pons and sometimes extrapontine areas also. It is commonly reported in settings of hyponatraemia or its rapid correction, but in the last few years it has also been reported in patients with diabetes in the absence of electrolyte disturbances or correction of serum osmolality. Here we report a case of a 20-year-old female patient, with a known history of type 1 diabetes mellitus, who presented with acute onset spastic quadriparesis with dysarthria and mild ataxia which evolved over 2 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2016-219148DOI Listing
May 2017
43 Reads

Central pontine myelinolysis associated with hypokalemia in a diabetic patient with sepsis.

Authors:
Sweety V Shinde

Neurol India 2017 May-Jun;65(3):674-675

Department of Pathology, B.Y.L Nair Hospital, Mumbai, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/neuroindia.NI_1092_16DOI Listing
May 2017
11 Reads

Osmotic Demyelination Syndrome in a Eunatremic Patient with Chronic Kidney Disease.

J Assoc Physicians India 2017 Mar;65(3):98-99

Junior Resident, Department of Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh.

Osmotic demyelination syndrome is classically associated with rapid correction of hyponatremia. However, it can occur in normonatremic patients with other electrolyte abnormalities. One must suspect osmotic demyelination syndrome in susceptible patients with other electrolyte abnormalities like hypokalemia and hypophosphatemia. Read More

View Article

Download full-text PDF

Source
March 2017
3 Reads

Secondary parkinsonism in a patient of psychogenic polydipsia.

BMJ Case Rep 2017 Apr 26;2017. Epub 2017 Apr 26.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 44-year-old man presented with history of slurring of speech, slowness in activities, abnormal posturing of the upper limbs and drooling of saliva from the mouth. He had a 5-yearlong history of compulsive water drinking, consuming 12-15 L of water every day. He was earlier evaluated for the same and found to have low serum sodium (126 mEq/L). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2016-218722DOI Listing
April 2017
11 Reads

Osmotic Demyelination Syndrome due to Severe Hyponatremia Mimicking Hypoxic Encephalopathy.

Fortschr Neurol Psychiatr 2017 Apr 24;85(4):212-215. Epub 2017 Apr 24.

Neurologie, Sankt Katharinen Krankenhaus, Frankfurt am Main.

Hyponatremia and its rapid correction is a well-known cause of osmotic demyelination most commonly affecting the pons. We report on a case of severe hyponatremia likely due to psychogenic polydipsia resulting in hypotonic hyperhydration with resulting cortical laminar necrosis on initial imaging, mimicking hypoxic brain damage. Pontine myelinolysis became apparent on follow-up imaging, illustrating the diagnostic challenges of extrapontine manifestations of severe hyponatremia. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-100460
Publisher Site
http://dx.doi.org/10.1055/s-0043-100460DOI Listing
April 2017
7 Reads

Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis.

Case Rep Neurol Med 2017 14;2017:1471096. Epub 2017 Mar 14.

Department of Neurology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA; Illinois Neurological Institute, OSF St. Francis Medical Center, Peoria, IL, USA.

Central pontine myelinolysis (CPM) is an acute demyelinating neurological disorder affecting primarily the central pons and is frequently associated with rapid correction of hyponatremia. Common clinical manifestations of CPM include spastic quadriparesis, dysarthria, pseudobulbar palsy, and encephalopathy of various degrees; however, coma, "locked-in" syndrome, or death can occur in most severe cases. Rarely, CPM presents with neuropsychiatric manifestations, such as personality changes, acute psychosis, paranoia, hallucinations, or catatonia, typically associated with additional injury to the brain, described as extrapontine myelinolysis (EPM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2017/1471096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368399PMC
March 2017
1 Read

[A case report of central pontine and extrapontine myelinolysis in the combination with spinal cord damage in a patient with tuberculosis in the lung].

Zh Nevrol Psikhiatr Im S S Korsakova 2017;117(2):117-123

City Scientific and Practical Center of Tuberculosis, Moscow, Russia.

A case report of central pontine and extrapontine myelinolysis in the combination with spinal cord damage is presented. The authors analyze literature data on this problem and discuss the pathogenesis and diagnostic issues of myelinolysis. Read More

View Article

Download full-text PDF

Source
http://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhi
Publisher Site
http://dx.doi.org/10.17116/jnevro201711721117-123DOI Listing
August 2017
3 Reads

Extrapontine myelinolysis manifested selectively by acute severe parkinsonian syndrome. Case Report.

Neuro Endocrinol Lett 2016 Nov;37(6):415-418

Department of Neurology, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.

Objectives: Osmotic demyelination syndrome (ODMS) is a rare and serious neurologic disorder with acute myelin disintegration, usually in the pontine area (central pontine myelinolysis) and to a lesser extent, even in other areas of the central nervous system (extrapontine myelinolysis). The main underlying mechanism is the change of serum osmolality with quick correction of low mineral levels, mainly hyponatraemia. Clinical manifestation is various and depends on the localization. Read More

View Article

Download full-text PDF

Source
November 2016
7 Reads

Central Pontine Myelinolysis Induced by Alcohol Withdrawal: A Case Report.

Ann Rehabil Med 2017 Feb 28;41(1):148-152. Epub 2017 Feb 28.

Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Busan, Korea.

Central pontine myelinolysis (CPM) is a demyelinating disorder characterized by the loss of myelin in the center of the basis pons, and is mainly caused by the rapid correction of hyponatremia. We report the case of a young woman who presented with gait disturbance and alcohol withdrawal, and who was eventually diagnosed with CPM. Generally, the cause and pathogenesis of CPM in chronic alcoholics remain unclear. Read More

View Article

Download full-text PDF

Source
http://e-arm.org/journal/view.php?doi=10.5535/arm.2017.41.1.
Publisher Site
http://dx.doi.org/10.5535/arm.2017.41.1.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344816PMC
February 2017
5 Reads

Does Accidental Overcorrection of Symptomatic Hyponatremia in Chronic Heart Failure Require Specific Therapeutic Adjustments for Preventing Central Pontine Myelinolysis?

J Clin Med Res 2017 Apr 21;9(4):266-272. Epub 2017 Feb 21.

Division of Cardiology, Istituto Nazionale per lo Studio e la Cura dei Tumori,"Fondazione Giovanni Pascale" IRCCS, via Mariano Semmola, 52, 80131 Napoli, Italy.

This review aims at summarizing essential aspects of epidemiology and pathophysiology of hyponatremia in chronic heart failure (CHF), to set the ground for a practical as well as evidence-based approach to treatment. As a guide through the discussion of the available evidence, a clinical case of hyponatremia associated with CHF is presented. For this case, the severe neurological signs at presentation justified an emergency treatment with hypertonic saline plus furosemide, as indicated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14740/jocmr2933wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330768PMC
April 2017
7 Reads

[Antypsychotic-induced central pontine myelinolysis in a congenital adrenal hyperplasia subject].

Rev Neurol 2017 03;64(5):235-236

Complejo Hospitalario Universitario de Granada, Granada, Espana.

View Article

Download full-text PDF

Source
March 2017
6 Reads

Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on F-FDG PET/CT.

World J Nucl Med 2017 Jan-Mar;16(1):56-58

Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Denmark.

Case report describing the finding of central pontine myelinolysis (CPM) using combined fluorine-18 ( F)-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The patient was a known alcoholic who, during admission was under treatment for hyponatremia, showed a significant decline in both motor and cognitive function. Combined F-FDG PET/CT showed localized FDG uptake in the pons, consistent with the finding of CPM observed on magnetic resonance imaging (MRI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1450-1147.174707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314665PMC
February 2017
1 Read

Treatable Leukoencephalopathy in a Patient with Hypophosphatemia.

Case Rep Neurol 2016 Sep-Dec;8(3):264-271. Epub 2017 Jan 3.

Department of Neurology, Kindai University Faculty of Medicine, Osakasayama, Japan.

We report the first patient with pathologically proven leukoencephalopathy associated with hypophosphatemia. A 61-year-old woman had repetitive episodes of decreased consciousness with pontine and pallidal lesions and extensive leukoencephalopathy on MRI, later found to be associated with hypophosphatemia. Although hypophosphatemia has been linked to central pontine and extrapontine myelinolysis (osmotic myelinolysis), lesions in the deep white matter have not been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000454854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260535PMC
January 2017
5 Reads

Neurologic manifestations of major electrolyte abnormalities.

Authors:
M Diringer

Handb Clin Neurol 2017 ;141:705-713

Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:

The brain operates in an extraordinarily intricate environment which demands precise regulation of electrolytes. Tight control over their concentrations and gradients across cellular compartments is essential and when these relationships are disturbed neurologic manifestations may develop. Perturbations of sodium are the electrolyte disturbances that most often lead to neurologic manifestations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-444-63599-0.00038-7DOI Listing
March 2017
11 Reads