102 results match your criteria Central Osteosarcoma Low-Grade

Parosteal osteosarcoma with a manifestation of subperiosteal low-grade central osteosarcoma.

Skeletal Radiol 2021 Mar 11. Epub 2021 Mar 11.

Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

We report the peculiar case of a parosteal osteosarcoma arising beneath the periosteum in a 12-year-old boy. He complained of difficulty in left knee flexion. Plain radiography showed a uniformly dense mineralized mass in the bone cortex and parosteal ossified nodules at the metaphysis and diaphysis of the left distal femur. Read More

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[Imaging findings in low-grade central osteosarcoma].

Rofo 2021 Jan 21. Epub 2021 Jan 21.

Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Germany.

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January 2021

A phase 1 study of entinostat in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1513, Pediatric Early Phase-Clinical Trial Network (PEP-CTN).

Pediatr Blood Cancer 2021 Apr 12;68(4):e28892. Epub 2021 Jan 12.

Department of Pediatrics, University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.

Background: Entinostat is an oral small molecule inhibitor of class I histone deacetylases (HDAC), which has not previously been evaluated in pediatrics. We conducted a phase I trial to determine the maximum tolerated dose/recommended phase 2 dose (MTD/RP2D), toxicity profile, pharmacokinetics (PK), and pharmacodynamics (PD) of entinostat in children with relapsed or refractory solid tumors including central nervous system (CNS) malignancies.

Methods: A rolling six dose escalation design evaluated two dose levels. Read More

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Atypical Enostoses-Series of Ten Cases and Literature Review.

Medicina (Kaunas) 2020 Oct 13;56(10). Epub 2020 Oct 13.

Department of Orthopedic Surgery 1, SUNY Upstate Medical University, Syracuse, New York, NY 13210, USA.

Bone islands (BI; enostoses) may be solitary or occur in the setting of osteopoikilosis (multiple bone islands) and are sometimes associated with Gardner's Syndrome (osteopoikilosis and colonic polyposis). Characteristic features of bone islands are (1) absence of pain or local tenderness, (2) typical radio dense central appearance with peripheral radiating spicules (rose thorn), (3) Mean CT (computerized tomography) attenuation values above 885 Hounsfield units (HU) (4) absence of uptake on bone scan and (5) radiographic stability over time. However, when enostoses display atypical features of pain, unusual radiographic appearance, aberrant HU, increased radiotracer uptake, and/or enlargement, they can be difficult to differentiate from more sinister bony lesions such as osteoblastic metastasis, low grade central osteosarcoma, osteoid osteoma and osteoblastoma. Read More

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October 2020

[Comparison of radiological and clinicopathological features of craniofacial fibro-osseous lesions].

Zhonghua Bing Li Xue Za Zhi 2020 Feb;49(2):122-128

Department of Maxillofacial Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China.

To investigate the clinicopathological and radiological features of benign fibro-osseous lesion (BFOL). Sixty-five cases of craniofacial BFOL, eight cases of peripheral ossifying fibroma (POF) and one case of low-grade central osteosarcoma diagnosed at Sichuan Provincial People's Hospital between January 2010 and March 2019 were collected. The clinicopathologic features, hematoxylin-eosin and immunohistochemical (IHC) staining and radiographic features were analyzed. Read More

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February 2020

Dedifferentiated low-grade central osteosarcoma with extensive cystic change initially treated as a simple bone cyst.

Pathol Res Pract 2020 Apr 20;216(4):152832. Epub 2020 Jan 20.

Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 815-8582, Japan. Electronic address:

Low-grade central osteosarcoma (LG-COS) is an uncommon variant of osteosarcoma (OS) that sometimes progresses to high-grade OS post-recurrence. We herein present a case of dedifferentiated LG-COS with extensive cystic change arising in the right iliac bone of a 26-year-old man. The LG-COS was initially diagnosed and managed as a simple bone cyst. Read More

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Chondromyxoid fibroma-like osteosarcoma: a case series and literature review.

BMC Musculoskelet Disord 2020 Jan 29;21(1):53. Epub 2020 Jan 29.

Department of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, 200050, China.

Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an exceedingly rare subtype of low-grade central osteosarcoma (LGCO), accounting for up to 10% of cases and making it difficult to diagnose. CMF-OS is frequently misdiagnosed on a radiological examination and biopsy, even after the initial operation. Its treatment is a controversial issue due to its low-grade classification and actual high-grade behavior. Read More

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January 2020

TREX1 suppression imparts cancer-stem-cell-like characteristics to CD133 osteosarcoma cells through the activation of E2F4 signaling.

Int J Clin Exp Pathol 2019 1;12(4):1134-1153. Epub 2019 Apr 1.

Department of Orthopaedics, The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China.

There is ongoing debate whether cancer stem cells (CSCs) could arise from the transformation of non-CSCs under specific conditions. In the present study, the role of the three prime repair exonuclease 1 (TREX1) in regulating CSC generation form human osteosarcoma cells was investigated. High, intermediate and low levels of TREX1 expression were respectively observed in low-grade, high-grade and metastatic human osteosarcoma samples, while the opposite tendency was observed for E2F4, a transcription factor associated with G2 arrest. Read More

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A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma.

Bone Joint J 2019 Jun;101-B(6):745-752

Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan; Rare Cancer Center, National Cancer Center Hospital, Tokyo, Japan.

Aims: The purpose of this study was to clarify the clinical behaviour, prognosis, and optimum treatment of dedifferentiated low-grade osteosarcoma (DLOS) diagnosed based on molecular pathology.

Patients And Methods: We retrospectively reviewed 13 DLOS patients (six men, seven women; median age 32 years (interquartile range (IQR) 27 to 38)) diagnosed using the following criteria: the histological coexistence of low-grade and high-grade osteosarcoma components in the lesion, and positive immunohistochemistry of mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase 4 (CDK4) associated with MDM2 amplification. These patients were then compared with 51 age-matched consecutive conventional osteosarcoma (COS) patients (33 men, 18 women; median age 25 years (IQR 20 to 38)) regarding their clinicopathological features. Read More

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Low-grade intramedullary osteosarcoma presenting with multiple sclerotic bone lesions.

Radiol Case Rep 2018 Oct 1;13(5):1042-1047. Epub 2018 Jun 1.

Department of Orthopaedic and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Central Jakarta 10430, Indonesia.

Low-grade intramedullary osteosarcoma is a less-aggressive type of osteosarcoma for which delays in diagnosis are common. We present the case of a 42-year-old woman with complaints of low back pain. Multiple imaging evaluations and biopsy procedures were necessary to make the final diagnosis. Read More

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October 2018

Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis.

Clin Sarcoma Res 2018 23;8:16. Epub 2018 Aug 23.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

Background: We studied two cases of rare fibrous bone tumors, namely desmoplastic fibroma (DF) and low-grade central osteosarcoma (LGCOS) resembling desmoplastic fibroma (DF-like LGCOS). As the clinical presentation, imaging features and histopathology of DF and DF-like LGOS show much overlap, the objective of this study was to investigate the value of cytogenetic analysis, molecular pathology and immunohistochemistry in discrimination of these two mimickers.

Case Presentation: A mutation in (S45F) and nuclear beta-catenin immunostaining were observed in DF. Read More

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Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.

Am J Surg Pathol 2018 09;42(9):1143-1155

Department of Pathology, West China Hospital, Sichuan University.

Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS). LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4. Read More

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September 2018

Low-Grade Central Osteosarcoma: Report of Two Unusual Morphologic Variants.

Indian J Surg Oncol 2018 Mar 13;9(1):74-78. Epub 2017 Nov 13.

IBS Hospital, New Delhi, India.

Low-grade central osteosarcoma (LGCO) is a rare subtype of osteosarcoma, constituting < 2% of all osteosarcomas. If not treated appropriately, the tumor can recur with higher-grade disease. We report two cases of low-grade central osteosarcoma with unusual morphologic features and belonging to different age groups. Read More

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Clinical, radiological, and pathological features of extraskeletal osteosarcoma.

Skeletal Radiol 2018 Sep 3;47(9):1213-1220. Epub 2018 Mar 3.

Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Objective: To evaluate clinical and radiological features of pathology-proven extraskeletal osteosarcomas.

Methods: This retrospective study was IRB-approved and HIPAA-compliant. Our pathology database was queried for cases of extraskeletal osteosarcoma. Read More

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September 2018

Denosumab-Treated Giant Cell Tumor of the Bone Mimicking Low-Grade Central Osteosarcoma.

J Pathol Transl Med 2018 Mar 12;52(2):133-135. Epub 2018 Feb 12.

Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

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Low-grade central osteosarcoma in proximal humerus: a rare entity.

Onco Targets Ther 2017 24;10:5165-5172. Epub 2017 Oct 24.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Low-grade central osteosarcoma is a rare subtype of tumor with low-grade malignancy. Currently, wide resection with negative resection margin is the standard treatment for this disease. The role of neoadjuvant chemotherapy in low-grade central osteosarcoma was controversial and was mostly considered for tumors containing high-grade focal areas. Read More

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October 2017

Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review.

Case Rep Pathol 2017 9;2017:2346316. Epub 2017 Mar 9.

Department of Pathology, APHM, Marseille, France.

Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine. The authors present the case of a 67-year-old man with progressive history of back pain. Physical examination revealed a mass located within the right paravertebral muscles. Read More

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Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls.

Hum Pathol 2017 05 22;63:89-97. Epub 2017 Feb 22.

Institute of Orthopedics "Carlos E. Ottolenghi,", Italian Hospital of Buenos Aires, 1199 Buenos Aires, Argentina.

Giant cell tumor (GCT) of bone is a locally aggressive, rarely metastasizing primary bone neoplasm that occurs most frequently in the epiphysis of long bones of young adults. It is composed of round, oval, or elongated mononuclear cells admixed with osteoclast-like giant cells that express receptor activator of nuclear factor κB (RANK). The mononuclear stromal cells express RANK ligand, a mediator of osteoclast activation. Read More

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Advances in the management of osteosarcoma.

F1000Res 2016 25;5:2767. Epub 2016 Nov 25.

St. Anna Children's Hospital, Department of Paediatrics, Medical University Vienna and Children's Cancer Research Institute CCRI, Vienna, Austria.

Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is usually a high-grade malignancy characterized by a very high risk for the development of pulmonary metastases. High-grade osteosarcomas are usually treated by preoperative and postoperative chemotherapy and surgery, with a very limited number of active agents available. Rarer lower-grade variants such as parosteal and periosteal osteosarcoma or low-grade central osteosarcoma are treated by surgery only. Read More

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November 2016

B7-H3 protein expression in a murine model of osteosarcoma.

Oncol Lett 2016 Jul 2;12(1):383-386. Epub 2016 Jun 2.

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Osteosarcoma is an aggressive type of bone tumor that commonly occurs in pediatric age groups. The complete molecular mechanisms behind osteosarcoma formation and progression require elucidation. B7-H3 is a protein of the B7 family that acts as a co-stimulatory molecule with a significant role in adaptive immune responses. Read More

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[Value of MDM2, CDK4 and SATB2 immunohistochemistry in histologic diagnosis of low-grade osteosarcoma].

Zhonghua Bing Li Xue Za Zhi 2016 Jun;45(6):387-92

Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Objective: To investigate the value of combined application of MDM2, CDK4 and SATB2 immunohistochemistry in pathological diagnosis of low-grade osteosarcoma.

Methods: Forty-seven cases of low grade osteosarcoma, including low grade central osteosarcoma (n=20) and parosteal osteosarcoma (n=27), were selected from Shanghai Jiaotong University Affiliated the Sixth People's Hospital. The clinical, radiography and histopathology were reviewed. Read More

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Multifocal low-grade central osteosarcoma: a rare case.

Skeletal Radiol 2016 Jul 5;45(7):997-1006. Epub 2016 Apr 5.

Douglass Hanly Moir Pathology, 14 Giffnock Avenue, Macquarie Park, NSW, 2113, USA.

Low-grade central osteosarcoma (LGCOS) is a rare variant of osteosarcoma. We present a rare case of multifocal LGCOS located in two distinct skeletal sites, initially noted as incidental findings on imaging for distant traumatic pathology. Both sites seemed small and innocuous on initial imaging, and were quiescent clinically, illustrating the value of close interval multimodal surveillance scanning. Read More

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Odontogenic myxoma with diffuse calcifications: a case report and review of a rare histologic feature.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Oct 3;122(4):e116-24. Epub 2016 Jan 3.

Associate Professor, Department of Oral Medicine and Surgery, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.

Calcifications have been rarely reported in odontogenic myxoma. We describe here an additional case and review all reported cases. A 45-year-old female patient presented with a gingival swelling around a mobile mandibular left second molar. Read More

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October 2016

Atypical manifestation of lung metastasis 17 years after initial diagnosis of low-grade central osteosarcoma.

J Orthop Sci 2017 Mar 31;22(2):357-361. Epub 2015 Oct 31.

Department of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. Electronic address:

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Successful correction of tibial bone deformity through multiple surgical procedures, liquid nitrogen-pretreated bone tumor autograft, three-dimensional external fixation, and internal fixation in a patient with primary osteosarcoma: a case report.

BMC Surg 2015 Dec 7;15:124. Epub 2015 Dec 7.

Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: In a previous report, we described a method of reconstruction using tumor-bearing autograft treated by liquid nitrogen for malignant bone tumor. Here we present the first case of bone deformity correction following a tumor-bearing frozen autograft via three-dimensional computerized reconstruction after multiple surgeries.

Case Presentation: A 16-year-old female student presented with pain in the left lower leg and was diagnosed with a low-grade central tibial osteosarcoma. Read More

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December 2015

High-grade focal areas in low-grade central osteosarcoma: high-grade or still low-grade osteosarcoma?

Clin Sarcoma Res 2015 29;5:23. Epub 2015 Oct 29.

Department of Oncology, Rizzoli Institute, Bologna, Italy.

Background: High-grade foci (grade 3 according to Broder's grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outcome in patients upgraded to high grade (grade 3) after a first diagnosis of low-grade osteosarcoma, following the detection of high-grade areas (grade 3) in the resected specimen.

Methods: Of the 132 patients with a diagnosis of low-grade central osteosarcoma at surgical biopsy at our Institute, 33 patients were considered eligible for the study. Read More

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November 2015

Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone.

Am J Surg Pathol 2016 Jan;40(1):72-80

*Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA †Department of Pathology, Miller School of Medicine, Jackson Memorial Hospital, University of Miami, Miami, FL ‡Department of Radiology §Department of Medicine, Division of Oncology ∥Department of Orthopaedics ¶Department of Pathology, Massachusetts General Hospital, Boston, MA.

Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm characterized by an abundance of osteoclastic giant cells that are induced by the neoplastic mononuclear cells; the latter express high levels of receptor activator of nuclear factor κ-B ligand (RANKL). Denosumab, a RANKL inhibitor, which is clinically used to treat GCT, leads to a marked alteration in the histologic appearance of the tumor with giant cell depletion and new bone deposition, leading to substantial histologic overlap with other primary tumors of bone. Most significantly, denosumab-treated GCT (tGCT) with abundant bone deposition may mimic de novo osteosarcoma, or GCT that has undergone malignant transformation. Read More

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January 2016

GNAS mutations are not detected in parosteal and low-grade central osteosarcomas.

Mod Pathol 2015 Oct 7;28(10):1336-42. Epub 2015 Aug 7.

Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK.

Parosteal osteosarcoma, low-grade central osteosarcoma, and fibrous dysplasia share similar histological features that may pose a diagnostic challenge. The detection of GNAS mutations in primary bone tumors has been useful in clinical practice for diagnosing fibrous dysplasia. However, the recent report of GNAS mutations being detected in a significant proportion of parosteal osteosarcoma challenges the specificity of this mutation. Read More

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October 2015

[Accuracy of different preoperative biopsy techniques in diagnosis of osteosarcomas and their value in prognostic evaluation].

Zhonghua Bing Li Xue Za Zhi 2015 May;44(5):315-9


Objective: To study the difference in pathologic diagnostic accuracy among different histologic subtypes of osteosarcoma and different methods of preoperative biopsy, and the influence of diagnostic accuracy on prognosis of osteosarcoma.

Methods: The preoperative biopsies, complete clinical, radiological and pathological data of 347 pathologically confirmed osteosarcomas were evaluated. According to the Pathological Diagnostic and Technical Specifications, the accuracy of preoperative biopsies was divided into 6 grades. Read More

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Diagnostic challenges of low-grade central osteosarcoma of jaw: a literature review.

J Dent (Shiraz) 2015 Jun;16(2):62-7

Student of Dentistry, Dept. of Oral and Maxillofacial Pathology, Yazd Dental School, Shahid Sadughi University of Medical Sciences, Yazd, Iran;

Unlabelled: Low Grade Central Osteosarcoma (LGCO) is a rare subtype of osteosarcoma that is less aggressive than conventional osteosarcoma. The importance of LGCO lies in the fact that regarding microscopic and radiographic features, it occasionally simulates some benign jaw lesions and would consequently be misdiagnosed in many patients. The present study was conducted to collect the information and descriptive analyses related to ten cases reported between 1987 and 2010, including a sample reported by the authors emphasizing on diagnostic errors and the prevailing misdiagnosis. Read More

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