98 results match your criteria Central Osteosarcoma Low-Grade


[Comparison of radiological and clinicopathological features of craniofacial fibro-osseous lesions].

Zhonghua Bing Li Xue Za Zhi 2020 Feb;49(2):122-128

Department of Maxillofacial Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China.

To investigate the clinicopathological and radiological features of benign fibro-osseous lesion (BFOL). Sixty-five cases of craniofacial BFOL, eight cases of peripheral ossifying fibroma (POF) and one case of low-grade central osteosarcoma diagnosed at Sichuan Provincial People's Hospital between January 2010 and March 2019 were collected. The clinicopathologic features, hematoxylin-eosin and immunohistochemical (IHC) staining and radiographic features were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.02.004DOI Listing
February 2020

Dedifferentiated low-grade central osteosarcoma with extensive cystic change initially treated as a simple bone cyst.

Pathol Res Pract 2020 Apr 20;216(4):152832. Epub 2020 Jan 20.

Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 815-8582, Japan. Electronic address:

Low-grade central osteosarcoma (LG-COS) is an uncommon variant of osteosarcoma (OS) that sometimes progresses to high-grade OS post-recurrence. We herein present a case of dedifferentiated LG-COS with extensive cystic change arising in the right iliac bone of a 26-year-old man. The LG-COS was initially diagnosed and managed as a simple bone cyst. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152832DOI Listing

Chondromyxoid fibroma-like osteosarcoma: a case series and literature review.

BMC Musculoskelet Disord 2020 Jan 29;21(1):53. Epub 2020 Jan 29.

Department of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xian Xia Road, Shanghai, 200050, China.

Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is an exceedingly rare subtype of low-grade central osteosarcoma (LGCO), accounting for up to 10% of cases and making it difficult to diagnose. CMF-OS is frequently misdiagnosed on a radiological examination and biopsy, even after the initial operation. Its treatment is a controversial issue due to its low-grade classification and actual high-grade behavior. Read More

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http://dx.doi.org/10.1186/s12891-020-3063-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990471PMC
January 2020

TREX1 suppression imparts cancer-stem-cell-like characteristics to CD133 osteosarcoma cells through the activation of E2F4 signaling.

Int J Clin Exp Pathol 2019 1;12(4):1134-1153. Epub 2019 Apr 1.

Department of Orthopaedics, The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China.

There is ongoing debate whether cancer stem cells (CSCs) could arise from the transformation of non-CSCs under specific conditions. In the present study, the role of the three prime repair exonuclease 1 (TREX1) in regulating CSC generation form human osteosarcoma cells was investigated. High, intermediate and low levels of TREX1 expression were respectively observed in low-grade, high-grade and metastatic human osteosarcoma samples, while the opposite tendency was observed for E2F4, a transcription factor associated with G2 arrest. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947077PMC

A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma.

Bone Joint J 2019 Jun;101-B(6):745-752

Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan; Rare Cancer Center, National Cancer Center Hospital, Tokyo, Japan.

Aims: The purpose of this study was to clarify the clinical behaviour, prognosis, and optimum treatment of dedifferentiated low-grade osteosarcoma (DLOS) diagnosed based on molecular pathology.

Patients And Methods: We retrospectively reviewed 13 DLOS patients (six men, seven women; median age 32 years (interquartile range (IQR) 27 to 38)) diagnosed using the following criteria: the histological coexistence of low-grade and high-grade osteosarcoma components in the lesion, and positive immunohistochemistry of mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase 4 (CDK4) associated with MDM2 amplification. These patients were then compared with 51 age-matched consecutive conventional osteosarcoma (COS) patients (33 men, 18 women; median age 25 years (IQR 20 to 38)) regarding their clinicopathological features. Read More

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http://dx.doi.org/10.1302/0301-620X.101B6.BJJ-2018-1207.R1DOI Listing
June 2019
18 Reads

Low-grade intramedullary osteosarcoma presenting with multiple sclerotic bone lesions.

Radiol Case Rep 2018 Oct 1;13(5):1042-1047. Epub 2018 Jun 1.

Department of Orthopaedic and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Central Jakarta 10430, Indonesia.

Low-grade intramedullary osteosarcoma is a less-aggressive type of osteosarcoma for which delays in diagnosis are common. We present the case of a 42-year-old woman with complaints of low back pain. Multiple imaging evaluations and biopsy procedures were necessary to make the final diagnosis. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137386PMC
October 2018
40 Reads

Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis.

Clin Sarcoma Res 2018 23;8:16. Epub 2018 Aug 23.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

Background: We studied two cases of rare fibrous bone tumors, namely desmoplastic fibroma (DF) and low-grade central osteosarcoma (LGCOS) resembling desmoplastic fibroma (DF-like LGCOS). As the clinical presentation, imaging features and histopathology of DF and DF-like LGOS show much overlap, the objective of this study was to investigate the value of cytogenetic analysis, molecular pathology and immunohistochemistry in discrimination of these two mimickers.

Case Presentation: A mutation in (S45F) and nuclear beta-catenin immunostaining were observed in DF. Read More

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-018-0104-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106748PMC
August 2018
12 Reads

Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.

Am J Surg Pathol 2018 09;42(9):1143-1155

Department of Pathology, West China Hospital, Sichuan University.

Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS). LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001125DOI Listing
September 2018
31 Reads

Low-Grade Central Osteosarcoma: Report of Two Unusual Morphologic Variants.

Indian J Surg Oncol 2018 Mar 13;9(1):74-78. Epub 2017 Nov 13.

IBS Hospital, New Delhi, India.

Low-grade central osteosarcoma (LGCO) is a rare subtype of osteosarcoma, constituting < 2% of all osteosarcomas. If not treated appropriately, the tumor can recur with higher-grade disease. We report two cases of low-grade central osteosarcoma with unusual morphologic features and belonging to different age groups. Read More

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http://dx.doi.org/10.1007/s13193-017-0713-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856698PMC
March 2018
60 Reads

Clinical, radiological, and pathological features of extraskeletal osteosarcoma.

Skeletal Radiol 2018 Sep 3;47(9):1213-1220. Epub 2018 Mar 3.

Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Objective: To evaluate clinical and radiological features of pathology-proven extraskeletal osteosarcomas.

Methods: This retrospective study was IRB-approved and HIPAA-compliant. Our pathology database was queried for cases of extraskeletal osteosarcoma. Read More

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http://dx.doi.org/10.1007/s00256-018-2908-6DOI Listing
September 2018
9 Reads

Denosumab-Treated Giant Cell Tumor of the Bone Mimicking Low-Grade Central Osteosarcoma.

J Pathol Transl Med 2018 Mar 12;52(2):133-135. Epub 2018 Feb 12.

Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

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http://dx.doi.org/10.4132/jptm.2016.12.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859236PMC
March 2018
30 Reads

Low-grade central osteosarcoma in proximal humerus: a rare entity.

Onco Targets Ther 2017 24;10:5165-5172. Epub 2017 Oct 24.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Low-grade central osteosarcoma is a rare subtype of tumor with low-grade malignancy. Currently, wide resection with negative resection margin is the standard treatment for this disease. The role of neoadjuvant chemotherapy in low-grade central osteosarcoma was controversial and was mostly considered for tumors containing high-grade focal areas. Read More

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http://dx.doi.org/10.2147/OTT.S142818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661444PMC
October 2017
2 Reads
1.342 Impact Factor

Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review.

Case Rep Pathol 2017 9;2017:2346316. Epub 2017 Mar 9.

Department of Pathology, APHM, Marseille, France.

Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine. The authors present the case of a 67-year-old man with progressive history of back pain. Physical examination revealed a mass located within the right paravertebral muscles. Read More

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http://dx.doi.org/10.1155/2017/2346316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362705PMC
March 2017
31 Reads

Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls.

Hum Pathol 2017 05 22;63:89-97. Epub 2017 Feb 22.

Institute of Orthopedics "Carlos E. Ottolenghi,", Italian Hospital of Buenos Aires, 1199 Buenos Aires, Argentina.

Giant cell tumor (GCT) of bone is a locally aggressive, rarely metastasizing primary bone neoplasm that occurs most frequently in the epiphysis of long bones of young adults. It is composed of round, oval, or elongated mononuclear cells admixed with osteoclast-like giant cells that express receptor activator of nuclear factor κB (RANK). The mononuclear stromal cells express RANK ligand, a mediator of osteoclast activation. Read More

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http://dx.doi.org/10.1016/j.humpath.2017.02.008DOI Listing
May 2017
5 Reads

Advances in the management of osteosarcoma.

F1000Res 2016 25;5:2767. Epub 2016 Nov 25.

St. Anna Children's Hospital, Department of Paediatrics, Medical University Vienna and Children's Cancer Research Institute CCRI, Vienna, Austria.

Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is usually a high-grade malignancy characterized by a very high risk for the development of pulmonary metastases. High-grade osteosarcomas are usually treated by preoperative and postoperative chemotherapy and surgery, with a very limited number of active agents available. Rarer lower-grade variants such as parosteal and periosteal osteosarcoma or low-grade central osteosarcoma are treated by surgery only. Read More

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http://dx.doi.org/10.12688/f1000research.9465.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130082PMC
November 2016
29 Reads

B7-H3 protein expression in a murine model of osteosarcoma.

Oncol Lett 2016 Jul 2;12(1):383-386. Epub 2016 Jun 2.

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Osteosarcoma is an aggressive type of bone tumor that commonly occurs in pediatric age groups. The complete molecular mechanisms behind osteosarcoma formation and progression require elucidation. B7-H3 is a protein of the B7 family that acts as a co-stimulatory molecule with a significant role in adaptive immune responses. Read More

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http://dx.doi.org/10.3892/ol.2016.4675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906827PMC
July 2016
29 Reads

[Value of MDM2, CDK4 and SATB2 immunohistochemistry in histologic diagnosis of low-grade osteosarcoma].

Zhonghua Bing Li Xue Za Zhi 2016 Jun;45(6):387-92

Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Objective: To investigate the value of combined application of MDM2, CDK4 and SATB2 immunohistochemistry in pathological diagnosis of low-grade osteosarcoma.

Methods: Forty-seven cases of low grade osteosarcoma, including low grade central osteosarcoma (n=20) and parosteal osteosarcoma (n=27), were selected from Shanghai Jiaotong University Affiliated the Sixth People's Hospital. The clinical, radiography and histopathology were reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2016.06.007DOI Listing
June 2016
12 Reads

Multifocal low-grade central osteosarcoma: a rare case.

Skeletal Radiol 2016 Jul 5;45(7):997-1006. Epub 2016 Apr 5.

Douglass Hanly Moir Pathology, 14 Giffnock Avenue, Macquarie Park, NSW, 2113, USA.

Low-grade central osteosarcoma (LGCOS) is a rare variant of osteosarcoma. We present a rare case of multifocal LGCOS located in two distinct skeletal sites, initially noted as incidental findings on imaging for distant traumatic pathology. Both sites seemed small and innocuous on initial imaging, and were quiescent clinically, illustrating the value of close interval multimodal surveillance scanning. Read More

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http://dx.doi.org/10.1007/s00256-016-2384-9DOI Listing
July 2016
6 Reads

Odontogenic myxoma with diffuse calcifications: a case report and review of a rare histologic feature.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Oct 3;122(4):e116-24. Epub 2016 Jan 3.

Associate Professor, Department of Oral Medicine and Surgery, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.

Calcifications have been rarely reported in odontogenic myxoma. We describe here an additional case and review all reported cases. A 45-year-old female patient presented with a gingival swelling around a mobile mandibular left second molar. Read More

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http://dx.doi.org/10.1016/j.oooo.2015.12.009DOI Listing
October 2016
6 Reads

Atypical manifestation of lung metastasis 17 years after initial diagnosis of low-grade central osteosarcoma.

J Orthop Sci 2017 Mar 31;22(2):357-361. Epub 2015 Oct 31.

Department of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jos.2015.08.002DOI Listing
March 2017
7 Reads

Successful correction of tibial bone deformity through multiple surgical procedures, liquid nitrogen-pretreated bone tumor autograft, three-dimensional external fixation, and internal fixation in a patient with primary osteosarcoma: a case report.

BMC Surg 2015 Dec 7;15:124. Epub 2015 Dec 7.

Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: In a previous report, we described a method of reconstruction using tumor-bearing autograft treated by liquid nitrogen for malignant bone tumor. Here we present the first case of bone deformity correction following a tumor-bearing frozen autograft via three-dimensional computerized reconstruction after multiple surgeries.

Case Presentation: A 16-year-old female student presented with pain in the left lower leg and was diagnosed with a low-grade central tibial osteosarcoma. Read More

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http://www.biomedcentral.com/1471-2482/15/124
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http://dx.doi.org/10.1186/s12893-015-0112-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672513PMC
December 2015
24 Reads

High-grade focal areas in low-grade central osteosarcoma: high-grade or still low-grade osteosarcoma?

Clin Sarcoma Res 2015 29;5:23. Epub 2015 Oct 29.

Department of Oncology, Rizzoli Institute, Bologna, Italy.

Background: High-grade foci (grade 3 according to Broder's grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outcome in patients upgraded to high grade (grade 3) after a first diagnosis of low-grade osteosarcoma, following the detection of high-grade areas (grade 3) in the resected specimen.

Methods: Of the 132 patients with a diagnosis of low-grade central osteosarcoma at surgical biopsy at our Institute, 33 patients were considered eligible for the study. Read More

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http://dx.doi.org/10.1186/s13569-015-0038-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627618PMC
November 2015
35 Reads

Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone.

Am J Surg Pathol 2016 Jan;40(1):72-80

*Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA †Department of Pathology, Miller School of Medicine, Jackson Memorial Hospital, University of Miami, Miami, FL ‡Department of Radiology §Department of Medicine, Division of Oncology ∥Department of Orthopaedics ¶Department of Pathology, Massachusetts General Hospital, Boston, MA.

Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm characterized by an abundance of osteoclastic giant cells that are induced by the neoplastic mononuclear cells; the latter express high levels of receptor activator of nuclear factor κ-B ligand (RANKL). Denosumab, a RANKL inhibitor, which is clinically used to treat GCT, leads to a marked alteration in the histologic appearance of the tumor with giant cell depletion and new bone deposition, leading to substantial histologic overlap with other primary tumors of bone. Most significantly, denosumab-treated GCT (tGCT) with abundant bone deposition may mimic de novo osteosarcoma, or GCT that has undergone malignant transformation. Read More

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http://pdfs.journals.lww.com/ajsp/2016/01000/Denosumab_treat
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000506DOI Listing
January 2016
41 Reads

GNAS mutations are not detected in parosteal and low-grade central osteosarcomas.

Mod Pathol 2015 Oct 7;28(10):1336-42. Epub 2015 Aug 7.

Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK.

Parosteal osteosarcoma, low-grade central osteosarcoma, and fibrous dysplasia share similar histological features that may pose a diagnostic challenge. The detection of GNAS mutations in primary bone tumors has been useful in clinical practice for diagnosing fibrous dysplasia. However, the recent report of GNAS mutations being detected in a significant proportion of parosteal osteosarcoma challenges the specificity of this mutation. Read More

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http://dx.doi.org/10.1038/modpathol.2015.91DOI Listing
October 2015
75 Reads

[Accuracy of different preoperative biopsy techniques in diagnosis of osteosarcomas and their value in prognostic evaluation].

Zhonghua Bing Li Xue Za Zhi 2015 May;44(5):315-9

E-mail:

Objective: To study the difference in pathologic diagnostic accuracy among different histologic subtypes of osteosarcoma and different methods of preoperative biopsy, and the influence of diagnostic accuracy on prognosis of osteosarcoma.

Methods: The preoperative biopsies, complete clinical, radiological and pathological data of 347 pathologically confirmed osteosarcomas were evaluated. According to the Pathological Diagnostic and Technical Specifications, the accuracy of preoperative biopsies was divided into 6 grades. Read More

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May 2015
33 Reads

Diagnostic challenges of low-grade central osteosarcoma of jaw: a literature review.

J Dent (Shiraz) 2015 Jun;16(2):62-7

Student of Dentistry, Dept. of Oral and Maxillofacial Pathology, Yazd Dental School, Shahid Sadughi University of Medical Sciences, Yazd, Iran;

Unlabelled: Low Grade Central Osteosarcoma (LGCO) is a rare subtype of osteosarcoma that is less aggressive than conventional osteosarcoma. The importance of LGCO lies in the fact that regarding microscopic and radiographic features, it occasionally simulates some benign jaw lesions and would consequently be misdiagnosed in many patients. The present study was conducted to collect the information and descriptive analyses related to ten cases reported between 1987 and 2010, including a sample reported by the authors emphasizing on diagnostic errors and the prevailing misdiagnosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445853PMC
June 2015
11 Reads

Clinical outcome of low-grade central osteosarcoma and role of CDK4 and MDM2 immunohistochemistry as a diagnostic adjunct.

J Orthop Sci 2015 May 5;20(3):529-37. Epub 2015 Mar 5.

Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea,

Introduction: Low-grade osteosarcoma encompasses parosteal osteosarcoma (POS) and low-grade central osteosarcoma (LCOS), with LCOS more rare than POS. LCOS is also more likely to be misdiagnosed and inappropriately treated with an intralesional procedure, due to its misleading radiological features and the overlap of its pathological characteristics with those of benign bone tumors. Therefore, as a diagnostic adjunct for LCOS, immunohistochemical assay with murine double-minute type 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) have been tried with controversial results. Read More

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http://www.sciencedirect.com/science/article/pii/S0949265815
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http://linkinghub.elsevier.com/retrieve/pii/S094926581530079
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http://dx.doi.org/10.1007/s00776-015-0701-0DOI Listing
May 2015
27 Reads

MDM2 and CDK4 expression in periosteal osteosarcoma.

Hum Pathol 2015 Apr 31;46(4):549-53. Epub 2014 Dec 31.

Pathology Department, Rizzoli Institute, Bologna, Italy 40136; Department of Pathology, Villa Erbosa Hospital, Bologna, Italy 40129.

Periosteal osteosarcoma is defined by the World Health Organization as an intermediate-grade, malignant, cartilaginous, and bone-forming neoplasm arising on the surface of bone. Unlike other subtypes of osteosarcoma, no data have been published about mouse double minute 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) expression. For this reason, we evaluated the molecular and immunohistochemical features of MDM2 and CDK4 in 27 cases relative to 20 patients with a diagnosis of periosteal osteosarcoma, surgically treated at the Rizzoli Institute between 1981 and 2014. Read More

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http://dx.doi.org/10.1016/j.humpath.2014.12.006DOI Listing
April 2015
28 Reads

Activating GNAS mutations in parosteal osteosarcoma.

Am J Surg Pathol 2014 Mar;38(3):402-9

Departments of *Laboratory Medicine and Pathology †Radiology, Mayo Clinic, Rochester, MN.

Parosteal osteosarcoma is a surface-based osteosarcoma that often exhibits deceptively bland cytologic features, hindering diagnosis in small biopsies or when correlative radiologic imaging is not readily available. A number of benign and malignant fibro-osseous lesions, including fibrous dysplasia (FD) and low-grade central osteosarcoma, fall within the morphologic differential diagnosis of parosteal osteosarcoma. Somatic mutations in GNAS, encoding the α-subunit of the heterotrimeric G protein complex (Gsα), occur in FD and McCune-Albright syndrome but have not been reported in parosteal osteosarcoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000144DOI Listing
March 2014
16 Reads

Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia.

World J Orthop 2013 18;4(4):327-32. Epub 2013 Oct 18.

Haris S Vasiliadis, Christina Arnaoutoglou, Sotiris Plakoutsis, Theodoros A Xenakis, Department of Orthopaedics, University Hospital of Ioannina, 45500 Ioannina, Greece.

We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Read More

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http://dx.doi.org/10.5312/wjo.v4.i4.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801255PMC
October 2013
33 Reads
2 Citations

[Salvage therapy by hemicortical excision and reconstruction for low-grade malignant bone tumour].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013 Jul;38(7):691-4

Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To treat low-grade limb malignant tumors with hemicortical excision and reconstruction of the defect with recycled pasteurized autograft.

Methods: From January 2005 to January 2011, 10 patients [age (27.0±6. Read More

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http://dx.doi.org/10.3969/j.issn.1672-7347.2013.07.007DOI Listing
July 2013
10 Reads

Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases.

Int J Clin Oncol 2014 Aug 24;19(4):731-8. Epub 2013 Jul 24.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan,

Background: Low-grade osteosarcoma, including low-grade central osteosarcoma and parosteal osteosarcoma, is an extremely rare variant, and the diagnosis is occasionally difficult. In this article we present cases of low-grade osteosarcomas that should be reviewed by a clinical oncologist.

Patients And Methods: Nine cases of histologically diagnosed Broder grade 1 osteosarcoma were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s10147-013-0592-zDOI Listing
August 2014
25 Reads

Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient.

Radiol Oncol 2013 Jun 21;47(2):192-6. Epub 2013 May 21.

Department of Orthopedics and Orthopedic Surgery, Graz, Austria.

Background: Low-grade central osteosarcoma is a very rare subtype of osteosarcoma with a predilection for the metaphysis of long bones and a peak incidence in the 3(rd) decade of life. Absence of specific clinical symptoms and a good prognosis after wide resection are the characteristics of this entity. Chemotherapy is not indicated in this highly differentiated tumour. Read More

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http://dx.doi.org/10.2478/raon-2013-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691094PMC
June 2013
17 Reads

Low-grade central osteosarcoma of the rib: a case report and brief review of the literature.

Case Rep Pathol 2013 14;2013:798435. Epub 2013 May 14.

Department of Pathology and Laboratory Medicine, 503 South Jackson Street, Louisville, KY 40202, USA.

Low-grade central osteosarcoma is a rare variant of osteosarcoma which comprises less than 1-2% of all osteosarcomas. Most low-grade osteosarcomas involve long bones, most commonly distal femur, and proximal tibia. Histologically this tumor is difficult to diagnose, and an unusual location makes this diagnosis even more challenging. Read More

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http://dx.doi.org/10.1155/2013/798435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666366PMC
June 2013
3 Reads

Fibrocartilaginous intramedullary bone forming tumor of the distal femur mimicking osteosarcoma.

J Korean Med Sci 2013 Apr 27;28(4):631-5. Epub 2013 Mar 27.

Department of Orthopaedic Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Fibrocartilaginous dysplasia (FCD) has occasionally led to a misdiagnosis and wrong decision which can significantly alter the outcome of the patients. A 9-yr-old boy presented with pain on his left distal thigh for 6 months without any trauma history. Initial radiographs showed moth eaten both osteolytic and osteosclerotic lesions and biopsy findings showed that the lesion revealed many irregular shaped and sclerotic mature and immature bony trabeculae. Read More

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http://dx.doi.org/10.3346/jkms.2013.28.4.631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617321PMC
April 2013
3 Reads

Low-grade central osteosarcoma arising from bone infarct.

Hum Pathol 2013 Jun 31;44(6):1184-9. Epub 2013 Jan 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 812-8582.

Bone infarct-associated sarcoma is a rare sarcoma, accounting for less than 1% of all bone sarcomas. Its histology usually reflects a high-grade sarcoma, such as malignant fibrous histiocytoma of bone or conventional osteosarcoma. Low-grade sarcoma arising from bone infarct has not been described well in the literature. Read More

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http://dx.doi.org/10.1016/j.humpath.2012.11.011DOI Listing
June 2013
23 Reads

Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis.

Anticancer Res 2012 Dec;32(12):5429-35

Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Low-grade central osteosarcoma (LGCOS) is a very rare low-grade malignant neoplasm that is often confused with a variety of benign fibro-osseous lesions. It rarely involves the small tubular bones of the feet. We present an unusual case of LGCOS arising in the third metatarsal bone of a 16-year-old boy. Read More

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December 2012
6 Reads

Low-grade central osteosarcoma: a difficult condition to diagnose.

Sarcoma 2012 16;2012:764796. Epub 2012 Jul 16.

The Royal Orthopaedic Hospital Oncology Service, Royal Orthopaedic Hospital, Bristol Road South, Birmingham B31 2AP, UK.

Low-grade central osteosarcoma (LGCO) is a rare variant of osteosarcoma which is difficult to diagnose. If not treated appropriately, the tumour can recur with higher-grade disease. We reviewed our experience of this condition to try and identify factors that could improve both diagnosis and outcome. Read More

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http://dx.doi.org/10.1155/2012/764796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407619PMC
August 2012
4 Reads

Low-grade central osteosarcoma of the orbit.

J Craniofac Surg 2012 May;23(3):e178-80

Department of Plastic and Reconstructive Surgery, Kanazawa Medical University, Ishikawa, Japan.

Low-grade central osteosarcoma is a rare type of osteosarcoma, representing fewer than 2% of all osteosarcomas. Approximately 80% of these tumors are located in the long bones, and they are particularly common in the distal and proximal tibia. However, they are rare in the craniofacial bones, and this tumor type has never been reported to occur in the orbit. Read More

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http://dx.doi.org/10.1097/SCS.0b013e31824de0efDOI Listing
May 2012
15 Reads

Syndecan-4 and fibronectin in osteosarcoma.

Pathology 2012 Jun;44(4):325-30

Department of Pathology, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.

Aims: Syndecan-4 (SDC4) and fibronectin (FN), which belong to the cell adhesion molecules, have been reported to correlate with tumour growth and invasion in various carcinomas. We aimed to investigate the prognostic value of these molecules in osteosarcoma.

Methods: Using immunohistochemistry, we compared the expression of these molecules in high grade osteosarcoma to low grade central osteosarcoma, osteoid osteoma and normal bone. Read More

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http://dx.doi.org/10.1097/PAT.0b013e328353447bDOI Listing
June 2012
11 Reads

Central low-grade osteosarcoma: a diagnostic challenge.

Authors:
S Fiona Bonar

Skeletal Radiol 2012 Apr 7;41(4):365-7. Epub 2012 Feb 7.

Douglass Hanly Moir Pathology, 14 Giffnock Avenue, Macquarie Park, NSW, 2113, North Ryde, Australia.

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http://dx.doi.org/10.1007/s00256-012-1359-8DOI Listing
April 2012
1 Read

A case of quadruple primary malignancies including breast, tongue, and thyroid cancers and osteosarcoma in a young female without karyotype abnormality.

Breast Cancer 2014 Jul 12;21(4):500-3. Epub 2011 May 12.

Division of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, 21 Yasago-Karimata, Nagakute, Aichi-gun, 480-1195, Japan.

The patient was a 41-year-old, premenopausal woman with a chief complaint of well-circumscribed palpable, right breast mass without nipple discharge. Although she noticed the lump 3 months previously, the size of the tumor (1.1 × 0. Read More

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http://link.springer.com/10.1007/s12282-011-0271-8
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http://dx.doi.org/10.1007/s12282-011-0271-8DOI Listing
July 2014
9 Reads

MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone.

Mod Pathol 2011 May 18;24(5):624-37. Epub 2011 Feb 18.

Department of Pathology, Trousseau University Hospital and University François Rabelais, Tours Cedex 9, France.

Low-grade osteosarcoma is a rare malignancy that may be subdivided into two main subgroups on the basis of location in relation to the bone cortex, that is, parosteal osteosarcoma and low-grade central osteosarcoma. Their histological appearance is quite similar and characterized by spindle cell stroma with low-to-moderate cellularity and well-differentiated anastomosing bone trabeculae. Low-grade osteosarcomas have a simple genetic profile with supernumerary ring chromosomes comprising amplification of chromosome 12q13-15, including the cyclin-dependent kinase 4 (CDK4) and murine double-minute type 2 (MDM2) gene region. Read More

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http://dx.doi.org/10.1038/modpathol.2010.229DOI Listing
May 2011
42 Reads

Prosthetic reconstruction for tumors of the distal tibia. Report of two cases.

Foot (Edinb) 2011 Sep 18;21(3):157-61. Epub 2011 Feb 18.

Department of Orthopaedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3, Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan.

Prosthetic reconstruction in two patients with malignant bone tumors of the distal tibia was conducted. The diagnoses were metastatic bone tumor in one patient and low grade central osteosarcoma in another. The mean duration of follow-up was 5. Read More

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http://dx.doi.org/10.1016/j.foot.2011.01.014DOI Listing
September 2011
4 Reads

[Low-grade central osteosarcoma: a clinicopathologic analysis of nine cases].

Zhonghua Bing Li Xue Za Zhi 2010 Nov;39(11):762-6

Department of Pathology, Institute of Cancer Research, Cancer Hospital, Fudan University and Department of Oncology, Shanghai Medical College, Shanghai 200032, China.

Objective: to study the clinicopathologic features and differential diagnosis of low-grade central osteosarcoma (LGCOS).

Methods: nine cases of LGCOS were retrieved from the archival consultation files. The clinical, radiologic and pathologic features were analyzed, with literature review. Read More

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November 2010
4 Reads

Imaging characteristics of primary osteosarcoma: nonconventional subtypes.

Radiographics 2010 Oct;30(6):1653-72

Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Osteosarcoma (OS) is a common primary malignant tumor of bone that produces osteoid matrix. According to the World Health Organization, OS of bone is classified into eight subtypes with distinct biologic behaviors and clinical outcomes: conventional, telangiectatic, small cell, low-grade central, secondary, parosteal, periosteal, and high-grade surface. Imaging plays a crucial role in the diagnosis of each subtype of OS and ultimately in patients' survival because the diagnosis is based on a combination of histopathologic and imaging features. Read More

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http://dx.doi.org/10.1148/rg.306105524DOI Listing
October 2010
8 Reads

Well-differentiated liposarcoma with low-grade osteosarcomatous component: an underrecognized variant.

Am J Surg Pathol 2010 Sep;34(9):1361-6

Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.

Mature bone formation in well-differentiated liposarcoma and dedifferentiated liposarcoma has been described as a reactive or "metaplastic" change in most reports, and its neoplastic nature has not been widely appreciated. We herein describe 9 cases of well-differentiated/dedifferentiated liposarcoma with distinct areas of fibroosseous tissue histologically indistinguishable from low-grade osteosarcomas, that is, parosteal osteosarcoma or low-grade central osteosarcoma. The tumors affected middle-aged to elderly patients, and occurred in the retroperitoneum and deep soft tissue of the extremities without connection to the skeletal system. Read More

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http://dx.doi.org/10.1097/PAS.0b013e3181ebcc45DOI Listing
September 2010
39 Reads

Expression of heat shock proteins in osteosarcomas.

Pathology 2010 ;42(5):421-5

Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea.

Aims: Heat shock proteins (HSPs) protect cells against stress-associated injuries and are overexpressed in several malignant tumours. We investigated the potential roles of HSP27, HSP60, and HSP70 in conventional and low grade central osteosarcoma.

Methods: Expressions of HSP27, HSP60, and HSP70 were analysed using immunohistochemistry on tissue sections from 52 cases of conventional osteosarcoma and 21 cases of low grade central osteosarcoma. Read More

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http://dx.doi.org/10.3109/00313025.2010.493866DOI Listing
October 2010
45 Reads

Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics.

Mod Pathol 2010 Sep 2;23(9):1279-88. Epub 2010 Jul 2.

Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.

Parosteal osteosarcoma and low-grade central osteosarcoma are two types of low-grade osteosarcoma that show similar clinical behaviors, histological features, and genetic background (ie, amplified sequences of 12q13-15, including MDM2 and CDK4). Low-grade osteosarcoma is often confused with benign lesions, and ancillary techniques to enhance diagnostic accuracy have been awaited. This study explores the use of MDM2 and CDK4 immunohistochemistry for the histological diagnosis of low-grade osteosarcoma. Read More

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http://www.nature.com/articles/modpathol2010124
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http://dx.doi.org/10.1038/modpathol.2010.124DOI Listing
September 2010
17 Reads