1,093,868 results match your criteria Central European Journal Of Energetic Materials[Journal]


A systematic review on reported outcomes and outcome measures in female idiopathic chronic pelvic pain for the development of a core outcome set.

BJOG 2020 Jul 12. Epub 2020 Jul 12.

Department of Obstetrics and Gynaecology, St Helier University Hospitals NHS Trust, Epsom &, London, KT18 7EG, United Kingdom.

Background: A core outcome set (COS) is required to address inconsistencies in outcome reporting in chronic pelvic pain (CPP) trials.

Objectives: Evaluation of reported outcomes and selected outcome measures in CPP trials by producing a comprehensive inventory to inform a COS.

Search Strategy: Systematic review of RCT identified from Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE and MEDLINE databases. Read More

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http://dx.doi.org/10.1111/1471-0528.16412DOI Listing

Psychodermatology in Iran: A Survey on Knowledge, Awareness and Practice Patterns in Iranian Dermatologists.

Dermatol Ther 2020 Jul 12:e14009. Epub 2020 Jul 12.

Psychodermatology, Psychiatry & Behavioral Sciences Department, College of Medicine, Central Michigan University, Saginaw, MI, USA.

Background: Psychodermatology is an interdisciplinary field in dermatology which involves the interaction between mind and skin. Studies from various parts of the world demonstrate generalized lack of knowledge regarding psychocutaneous disorders among dermatologists. We provide this survey to evaluate the knowledge, awareness, and practice patterns of Iranian dermatologists about psychodermatology. Read More

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http://dx.doi.org/10.1111/dth.14009DOI Listing

Randomised phase II study comparing alternating cycles of sunitinib and everolimus versus standard sequential administration in first-line metastatic renal carcinoma (SUNRISES study).

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.

Background: Alternating blockade of vascular endothelial growth factor receptor (VEGFR) and mammalian target of rapamycin (mTOR) pathways could potentially prevent the occurrence of resistance to anti-VEGFR therapy in metastatic renal cell carcinoma (mRCC).

Methods: SUNRISES, a randomised open-label phase II study, investigated the efficacy of alternating cycles of sunitinib and everolimus compared to standard sequential treatment of sunitinib followed by everolimus upon progression. Treatment-naïve patients with clear-cell mRCC were included. Read More

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http://dx.doi.org/10.1111/bju.15165DOI Listing

IL17RA variations showed no associations with post-bronchiolitis asthma or lung function.

Pediatr Int 2020 Jul 12. Epub 2020 Jul 12.

Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Background: Interleukin-17A (IL-17A) and IL-17F are involved with pathogenesis of asthma and allergy. Interleukin-17 receptor A (IL-17RA), encoded by the IL17RA gene, is a common receptor for IL-17A and IL-17F. The aim of the present study was to evaluate the association of IL17RA gene variations with asthma, allergy and lung function at school age in children prospectively followed-up after hospitalization for bronchiolitis in early infancy. Read More

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http://dx.doi.org/10.1111/ped.14387DOI Listing

Spruce beetle outbreak was not driven by drought stress: evidence from a tree-ring iso-demographic approach indicate temperatures were more important.

Glob Chang Biol 2020 Jul 11. Epub 2020 Jul 11.

Department of Wildland Resources and Ecology Center, Utah State University, Logan, UT, 84322, USA.

Climate change has amplified eruptive bark beetle outbreaks over recent decades, including spruce beetle (Dendroctonus rufipennis). However, for projecting future bark beetle dynamics there is a critical lack of evidence to differentiate how outbreaks have been promoted by direct effects of warmer temperatures on beetle life cycles vs indirect effects of drought on host susceptibility. To diagnose whether drought-induced host-weakening was important to beetle attack success we used an iso-demographic approach in Engelmann spruce (Picea engelmannii) forests that experienced widespread mortality caused by spruce beetle outbreaks in the 1990s, during a prolonged drought across the central and southern Rocky Mountain region. Read More

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http://dx.doi.org/10.1111/gcb.15274DOI Listing

Neonatal Apneic Phenotype in a Murine Congenital Central Hypoventilation Syndrome Model is Induced Through Non-Cell Autonomous Developmental Mechanisms.

Brain Pathol 2020 Jul 12. Epub 2020 Jul 12.

The Ohio State University College of Medicine, Department of Pathology, Division of Neuropathology, Columbus, United States.

Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor PHOX2B. Some CCHS patients suffer mainly from deficiencies in CO and/or O respiratory chemoreflex, whereas other patients present with full apnea shortly after birth. Our goal was to identify the neuropathological mechanisms of apneic presentations in CCHS. Read More

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http://dx.doi.org/10.1111/bpa.12877DOI Listing

Changes in ocular biometry during short-term accommodation in children.

Ophthalmic Physiol Opt 2020 Jul 12. Epub 2020 Jul 12.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

Purpose: Near work has been linked with myopia development; however, the underlying mechanism remains unclear. Small increases in axial length during accommodation have previously been reported in adults, and therefore, this study aimed to examine if accommodation-induced changes in ocular biometry also occur in school-aged children.

Methods: A range of ocular biometric measurements were captured during brief accommodation tasks at four demands (0, 3, 6, and 9 D), in a group of 87 non-myopic, school-aged children using a Badal optometer mounted to a non-contact optical biometer (Zeiss IOLMaster 700, https://www. Read More

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http://dx.doi.org/10.1111/opo.12711DOI Listing

Treatment of vascular soft tissue malformations: A Retrospective Study of 90 patients from Albania.

Dermatol Ther 2020 Jul 11:e14006. Epub 2020 Jul 11.

Central MichiganUniversity, Saginaw, MI, USA.

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http://dx.doi.org/10.1111/dth.14006DOI Listing

Impact of Rotavirus Vaccine on Admissions due to Acute Gastroenteritis and Rotavirus Gastroenteritis in Israel.

Acta Paediatr 2020 Jul 12. Epub 2020 Jul 12.

Pediatric Infectious Disease Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Aim: We examined the impact of insertion of the Rotavirus vaccine (RVV) into the Israeli national immunization program (NIP) on hospitalizations due to both acute gastroenteritis (AGE) and Rotavirus gastroenteritis (RVGE( in children.

Methods: We retrospectively analyzed the medical records of children aged <5 years admitted with a diagnosis of AGE between 2008 and 2016 in two children's hospitals in central Israel. Clinical, laboratory, microbiological data and RV immunization status were retrieved. Read More

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http://dx.doi.org/10.1111/apa.15480DOI Listing

Prefrontal dopaminergic system and its role in working memory and cognition in spinal cord-injured rats.

Exp Physiol 2020 Jul 12. Epub 2020 Jul 12.

Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

New Findings: What is the central question of this study? How dose spinal cord injury affects the prefrontal cortex function and expression of dopamine receptors? What is the main finding and its importance? Spinal cord injury impaired the cognitive function in this study, which is approved by decreased dopamine receptors expression in the prefrontal cortex.

Abstract: The effect of spinal cord injury (SCI) is widely studied on paraplegia and motor areas of the brain, but its mechanisms in memory and cognitive impairment remains controversial. Here, we focused on the impact of SCI on prefrontal performance via dopamine levels and receptors. Read More

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http://dx.doi.org/10.1113/EP088537DOI Listing

Enolase-phosphatase 1 acts as an oncogenic driver in glioma.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China.

Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in l-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. Read More

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http://dx.doi.org/10.1002/jcp.29926DOI Listing

The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions.

Scand J Immunol 2020 Jul 12:e12933. Epub 2020 Jul 12.

Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.

Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Read More

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http://dx.doi.org/10.1111/sji.12933DOI Listing

Statistical characterization of the linear attenuation coefficient in polychromatic CT scans.

Med Phys 2020 Jul 11. Epub 2020 Jul 11.

Applied Chest Imaging Laboratory (ACIL), Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA), USA.

Purpose: To provide a unifying statistical model that characterizes the integrated X-ray intensity at the detector after logarithmic transformation and can be extended to the characterization of CT numbers in the reconstructed image.

Methods: We study the statistical characteristics of polyenergetic X-ray beams in the detector. Firstly, we consider the characterization of the integrated X-ray intensity at the detector through a probabilistic model (Compound Poisson) that describes its statistics. Read More

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http://dx.doi.org/10.1002/mp.14384DOI Listing

Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis.

J Neurochem 2020 Jul 12. Epub 2020 Jul 12.

Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, 17 Liverpool street, Hobart, TAS, 7000, Australia.

Neuropeptide Y (NPY) is an endogenous peptide of the central and enteric nervous systems which has gained significant interest as a potential neuroprotective agent for treatment of neurodegenerative disease. Amyotrophic lateral sclerosis (ALS) is an aggressive and fatal neurodegenerative disease characterised by motor deficits and motor neuron loss. In ALS, recent evidence from ALS patients and animal models has indicated that NPY may have a role in the disease pathogenesis. Read More

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http://dx.doi.org/10.1111/jnc.15125DOI Listing

Accumulation of amyloid beta in human glioblastomas.

Clin Exp Immunol 2020 Jul 12. Epub 2020 Jul 12.

Physiology department, Medical School, Universidad Central del Caribe, Ave Laurel, Santa Juanita, Bayamon, PR 00956, Puerto Rico.

Many cancer types are intrinsically associated with specific types of amyloidosis, in which amyloidis accumulated locally inside tumors or systemically. Usually, this condition relates to the hyper-production of specific amylogenic proteins. Recently, we found that the accumulation of amyloid beta (Aβ) peptide immunofluorescence is linked to glioma cells in mouse tumors. Read More

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http://dx.doi.org/10.1111/cei.13493DOI Listing

Efficacy Of Preoperative Gabapentin on Pain Severity after Posterior Urethral Surgery:A Randomized, Double-Blind, Placebo-Controlled Study.

Urol J 2020 Jun 18. Epub 2020 Jun 18.

Professor of Urology, Reconstructive Urology Department, Shohada-e -Tajrish hospital, Shahid Beheshti Medical Science University, Iran.

Purpose: Prevention and treatment of urethroplastic postoperative pain is a major challenge in post-surgery care. gabapentin can treat postoperative pain by preventing excessive sensitivity to the central nervous system. we have tried to compare the effect of gabapentin with the placebo on reducing the pain associated with posterior urethroplasty in patients. Read More

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http://dx.doi.org/10.22037/uj.v0i0.5598DOI Listing

Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer.

Cancer Chemother Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.

Gemcitabine (GEM), as an anti-metabolic nucleoside analog, has been shown to have anticancer effects in various tumors, but its chemotherapy resistance is still an important factor leading to poor prognosis of cancer patient. A large number of studies in recent years have shown that autophagy plays an important role in the chemotherapy sensitivity of many tumors, including pancreatic, non-small cell lung, and bladder cancer. However, whether GEM causes autophagy in gallbladder cancer (GBC) and whether it is related to chemotherapy resistance is unknown. Read More

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http://dx.doi.org/10.1007/s00280-020-04100-5DOI Listing

Repetitive transcranial magnetic stimulation as an alternative therapy for stroke with spasticity: a systematic review and meta-analysis.

J Neurol 2020 Jul 11. Epub 2020 Jul 11.

Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China.

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) can be used to manage post-stroke spasticity, but a meta-analysis of the recent randomized-controlled trials (RCTs) is lacking. Our aim is to perform a meta-analysis of the RCTs that investigated the efficacy of rTMS in patients with post-stroke spasticity. PubMed, Embase, and Cochrane Library databases were searched for eligible papers published up to February 2020. Read More

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http://dx.doi.org/10.1007/s00415-020-10058-4DOI Listing

Dysphagia in Lateral Medullary Syndrome: A Narrative Review.

Dysphagia 2020 Jul 11. Epub 2020 Jul 11.

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 317-1, Daemyung dong, Namgu, Daegu, 705-717, Republic of Korea.

Dysphagia is a common clinical feature of lateral medullary syndrome (LMS) and is clinically relevant because it is related to aspiration pneumonia, malnutrition, increased mortality, and prolonged hospital stay. Herein, the pathophysiology, prognosis, and treatment of dysphagia in LMS are reviewed. The pathophysiology, prognosis, and treatment of dysphagia in LMS are closely interconnected. Read More

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http://dx.doi.org/10.1007/s00455-020-10158-3DOI Listing

Tomisaku Kawasaki and Kawasaki disease.

Childs Nerv Syst 2020 Jul 11. Epub 2020 Jul 11.

University of Florida, Division of General Internal Medicine, 2000 SW Archer Rd., Gainesville, FL, 32608, USA.

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http://dx.doi.org/10.1007/s00381-020-04784-3DOI Listing

Clinical characteristics and predictors of permanent stoma in rectal cancer patients underwent anterior resections: the value of preoperative prognostic nutritional index.

Int J Clin Oncol 2020 Jul 11. Epub 2020 Jul 11.

Department of Essential Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.

Objectives: This study was aimed to investigate the correlation between preoperative prognostic nutritional index (PNI) and permanent stoma (PS) in patients with defunctioning stoma (DS) after anterior resections and, based on it, to reveal the clinical value of PNI on clinical strategies about the selection of stoma location.

Methods: A total of 281 consecutive rectal cancer patients who accepted anterior resection and DS in the National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University from June 2008 to June 2018 were enrolled in this study. Receiver operating characteristic (ROC) curve for PNI was performed to discriminate PS. Read More

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http://dx.doi.org/10.1007/s10147-020-01743-5DOI Listing

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance.

Cell Mol Life Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Stomatology, NHC Key Laboratory of Carcinogenesis, Xiangya Hospital, Central South University, Changsha, 410078, China.

The successful treatment of human cancers by immunotherapy has been made possible by breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD-1/PD-L1. However, the immunosuppressive effect of the tumor microenvironment still represents an important bottleneck that limits the success of immunotherapeutic approaches. The tumor microenvironment influences the metabolic crosstalk between tumor cells and tumor-infiltrating immune cells, creating competition for the utilization of nutrients and promoting immunosuppression. Read More

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http://dx.doi.org/10.1007/s00018-020-03581-0DOI Listing

Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis.

Curr Top Behav Neurosci 2020 Jul 12. Epub 2020 Jul 12.

Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA.

Tinnitus and hyperacusis are debilitating conditions often associated with aging or exposure to intense noise or ototoxic drugs. One of the most reliable methods of inducing tinnitus is with high doses of sodium salicylate, the active ingredient in aspirin. High doses of salicylate have been widely used to investigate the functional neuroanatomy of tinnitus and hyperacusis. Read More

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http://dx.doi.org/10.1007/7854_2020_156DOI Listing

Can CT predict the development of oroantral fistula in patients undergoing maxillary third molar removal?

Oral Maxillofac Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction.

Methods: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1007/s10006-020-00878-zDOI Listing

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics.

Jpn J Radiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer's disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. Read More

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http://dx.doi.org/10.1007/s11604-020-01017-0DOI Listing

Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders.

Naunyn Schmiedebergs Arch Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, 64049-550, Brazil.

The compound (+)-limonene epoxide has antioxidant, anxiolytic, and antihelminthic properties. However, investigations to determine its long-term exposure were not performed. We investigated the systemic toxicological profile after chronic exposure as well as the antidepressant and antiepileptic potentialities of (+)-limonene epoxide on mice. Read More

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http://dx.doi.org/10.1007/s00210-020-01943-wDOI Listing

Altered lncRNAs Transcriptomic Profiles in Atherosclerosis-Induced Ischemic Stroke.

Cell Mol Neurobiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, People's Republic of China.

Long non-coding RNAs (lncRNAs) can not only regulate gene transcription and translation, but also participate in the development of central nervous system diseases as epigenetic modification factors. However, their functional significance in atherosclerosis-induced ischemic stroke (AIIS) is unclear. The study aimed to screen out differentially expressed lncRNAs (delncRNAs), and to elucidate their potential regulatory mechanisms in the pathophysiology of AIIS. Read More

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http://dx.doi.org/10.1007/s10571-020-00918-yDOI Listing

Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives.

Arch Gynecol Obstet 2020 Jul 11. Epub 2020 Jul 11.

Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland.

Purpose: To examine whether personal history of nausea or history of nausea and vomiting of pregnancy (NVP) in relatives are risk factors for a woman to suffer from NVP. Further, to evaluate if these factors are associated with the severity of NVP.

Methods: Cohort study of 2411 pregnant women recruited from maternity health care clinics. Read More

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http://dx.doi.org/10.1007/s00404-020-05683-3DOI Listing

Susceptibility trends of ceftolozane/tazobactam and comparators when tested against European Gram-negative bacterial surveillance isolates collected during 2012-18.

J Antimicrob Chemother 2020 Jul 10. Epub 2020 Jul 10.

JMI Laboratories, North Liberty, IA, USA.

Background: The Program to Assess Ceftolozane/Tazobactam Susceptibility (PACTS) monitors the in vitro activity of ceftolozane/tazobactam and numerous antimicrobial agents against Gram-negative bacteria worldwide.

Objectives: To evaluate the activity of ceftolozane/tazobactam and resistance trends among Pseudomonas aeruginosa and Enterobacterales isolates in Europe between 2012 and 2018.

Methods: P. Read More

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http://dx.doi.org/10.1093/jac/dkaa278DOI Listing

Diffuse dermal angiomatosis: case report of a distinct skin presentation.

Rheumatology (Oxford) 2020 Jul 12. Epub 2020 Jul 12.

Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.

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http://dx.doi.org/10.1093/rheumatology/keaa311DOI Listing

Investigating the genetic characteristics of the Csangos, a traditionally Hungarian speaking ethnic group residing in Romania.

J Hum Genet 2020 Jul 11. Epub 2020 Jul 11.

Department of Medical Genetics, Clinical Centre, University of Pécs, Pécs, Hungary.

Csango people are an East-Central European ethnographic group living mostly in the historical region of Moldavia, Romania. Their traditional language, the Csango is an old Hungarian dialect, which is a severely endangered language due to language shift. Their origin is still disputed among experts and there are many hypotheses since the 19th century. Read More

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http://dx.doi.org/10.1038/s10038-020-0799-6DOI Listing

ADHD Is Associated with a Higher Risk for Traumatic Events, Self-Reported PTSD, and a Higher Severity of PTSD Symptoms in Alcohol-Dependent Patients.

Eur Addict Res 2020 Jul 10:1-9. Epub 2020 Jul 10.

MEDIAN Klinik Wilhelmsheim, Oppenweiler, Germany.

Introduction: Alcohol dependence (AD) is frequently associated with attention-deficit/hyperactivity disorder (ADHD) as well as with posttraumatic stress disorder (PTSD).

Objective: Aim of this study was to investigate whether in patients with AD, ADHD is associated with an increased rate of exposure to potentially traumatic events (PTEs) and PTSD, with increased PTSD severity and higher impact on daily functioning.

Methods: Patients with AD were thoroughly assessed for ADHD during long-term residential treatment. Read More

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http://dx.doi.org/10.1159/000508918DOI Listing

The Development of Adolescent Chronic Pain following Traumatic Brain Injury and Surgery: The Role of Diet and Early Life Stress.

Dev Neurosci 2020 Jul 10:1-10. Epub 2020 Jul 10.

Department of Neuroscience, Central Clinical School/Monash University, Melbourne, Victoria, Australia,

Pain is evolutionarily necessary for survival in that it reduces tissue damage by signaling the body to respond to a harmful stimulus. However, in many circumstances, acute pain becomes chronic, and this is often dysfunctional. Adolescent chronic pain is a growing epidemic with an unknown etiology and limited effective treatment options. Read More

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http://dx.doi.org/10.1159/000508663DOI Listing

Designing and validation of a yoga-based module for obesity with metabolic comorbidities.

J Complement Integr Med 2020 Jul 13. Epub 2020 Jul 13.

Department of Yoga, Central University of Rajasthan, Ajmer, India.

Objectives Obesity is a condition of increased adipose tissue in the body, which is commonly associated with various comorbidities like diabetes, hypertension, arthritis, back pain, and many others. Yoga modules have been designed and validated for obesity; however, we couldn't find any specific module for metabolic syndrome, a condition which includes obesity, diabetes mellitus type 2 and/or hypertension together. Keeping this in view, our study aimed to develop and validate a specific generic yoga-based intervention module for metabolic syndrome patients. Read More

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http://dx.doi.org/10.1515/jcim-2019-0249DOI Listing

Management of acute gastrointestinal bleeding. Multidisciplinary guideline proposal.

Orv Hetil 2020 07;161(30):1231-1242

Általános Orvostudományi Kar, Sürgősségi Betegellátó Osztály,Semmelweis Egyetem, Budapest.

Gastrointestinal bleeding has a profound impact on public health due to its high prevalence and severity. With the elderly population taking more anticoagulants/antiaggregants/non-steroid anti-inflammatory drugs, the digestive bleeding will certainly raise more and more challenges in quantity as well as in severity for the public healthcare system. The emergency medicine specialists and gastroenterologists have a central role in the management of patients presenting with gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1556/650.2020.31807DOI Listing

Bioarchaeological reconstruction of physiological stress during social transition in Albania.

Int J Paleopathol 2020 Jul 9;30:118-129. Epub 2020 Jul 9.

University of Georgia, Department of Anthropology, 250 Baldwin Hall, Athens, GA, 30602, USA. Electronic address:

Objective: We test the hypothesis that physiological stress increased in response to increasing social turmoil following waves of colonization and social transition. The ways local conditions, including variation in geography, environment, and levels of urbanization impact physiological stress are also explored.

Materials: In Albania, the historic period is a sequence of different waves of colonization. Read More

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http://dx.doi.org/10.1016/j.ijpp.2020.06.003DOI Listing

"I Do not know them" - Capgras syndrome associated with porencephaly and agenesis of the Splenium.

Asian J Psychiatr 2020 Jul 7;54:102289. Epub 2020 Jul 7.

Central Queensland Mental Health, Alcohol and Other Drugs Services and Faculty of Medicine, The University of Queensland RCS, Rockhampton, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajp.2020.102289DOI Listing

Cardiorespiratory and autonomic function in epileptic seizures: A video-EEG monitoring study.

Epilepsy Behav 2020 Jul 9;111:107271. Epub 2020 Jul 9.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne 3000, Victoria, Australia; Department of Neurology, The Royal Melbourne Hospital, Parkville 3050, Victoria, Australia; The Epilepsy Unit, Alfred Health, Melbourne 3004, Victoria, Australia; Department of Medicine (The Royal Melbourne Hospital), The University of Melbourne, Parkville 3050, Victoria, Australia.

Purpose: Seizure-induced cardiorespiratory and autonomic dysfunction has long been recognized, and growing evidence points to its implication in sudden unexpected death in epilepsy (SUDEP). However, a comprehensive understanding of cardiorespiratory function in the preictal, ictal, and postictal periods are lacking.

Methods: We examined continuous cardiorespiratory and autonomic function in 157 seizures (18 convulsive and 139 nonconvulsive) from 70 consecutive patients who had a seizure captured on concurrent video-encephalogram (EEG) monitoring and polysomnography between February 1, 2012 and May 31, 2017. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107271DOI Listing

Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases.

DNA Repair (Amst) 2020 Jun 18;94:102900. Epub 2020 Jun 18.

Genome Damage Stability Centre, University of Sussex, Falmer Road, Brighton, BN1 9RQ, UK. Electronic address:

DNA topoisomerases alleviate the torsional stress that is generated by processes that are central to genome metabolism such as transcription and DNA replication. To do so, these enzymes generate an enzyme intermediate known as the cleavage complex in which the topoisomerase is covalently linked to the termini of a DNA single- or double-strand break. Whilst cleavage complexes are normally transient they can occasionally become abortive, creating protein-linked DNA breaks that threaten genome stability and cell survival; a process promoted and exploited in the cancer clinic by the use of topoisomerase 'poisons'. Read More

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http://dx.doi.org/10.1016/j.dnarep.2020.102900DOI Listing

Energy expenditure early after liver transplantation: better measured than predicted.

Nutrition 2020 Mar 20;79-80:110817. Epub 2020 Mar 20.

Department of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Objective: There is no consensus on how to estimate energy requirements after liver transplantation (LT). The aim of this study was to compare measured resting energy expenditure (REE) with predictive equations and fixed factors, and evaluate whether clinical variables were associated with REE.

Methods: During the period of 2011 through 2018, REE measured with indirect calorimetry and predicted by the Harris and Benedict (HB) equation was compared in patients during the first 30 postoperative days after LT. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110817DOI Listing

Management of Idiopathic CNS inflammatory diseases during the COVID-19 pandemic: Perspectives and strategies for continuity of care from a South East Asian Center with limited resources.

Authors:
S Viswanathan

Mult Scler Relat Disord 2020 Jul 3;44:102353. Epub 2020 Jul 3.

Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia. Electronic address:

The Covid-19 pandemic poses a grave health management challenge globally of unprecedented nature. Management of idiopathic Central Nervous system inflammatory disorders (iCNSID) such as Multiple sclerosis, Neuromyelitis optica and its spectrum disorders and related conditions during this pandemic needs to be addressed with affirmative and sustainable strategies in order to prevent disease related risks, medication related complications and possible COVID-19 disease associated effects. Global international iCNSIDs agencies and recent publications are attempting to address this but such guidance is not available in South East Asia. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102353DOI Listing

Salinity alleviates the arsenic toxicity in the facultative halophyte Salvadora persica L. by the modulations of physiological, biochemical, and ROS scavenging attributes.

J Hazard Mater 2020 Jul 2;401:123368. Epub 2020 Jul 2.

Plant Omics Division, CSIR- Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Gijubhai Badheka Marg, Bhavnagar, 364002, Gujarat, India; Academy of Scientific and Innovative Research, CSIR- Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar, 364002, Gujarat, India. Electronic address:

Heavy metal(loid)s contamination in soil is a major environmental concern that limits agricultural yield and threatens human health worldwide. Arsenic (As) is the most toxic non-essential metalloid found in soil which comes from various natural as well as human activities. S. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123368DOI Listing

Cross-network interactions in social cognition: A review of findings on task related brain activation and connectivity.

Cortex 2020 May 22;130:142-157. Epub 2020 May 22.

Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Theory of Mind, empathy, and action observation are central themes in social neuroscience research. Meta-analyses of functional neuroimaging studies show substantial heterogeneity in brain activation for these cognitive abilities, depending on the type of experimental task used. We followed up on these findings by a comparison to basic connectivity networks of the brain. Read More

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http://dx.doi.org/10.1016/j.cortex.2020.05.006DOI Listing

Analysis of the transition condition of rear-end collisions using time-to-collision index and vehicle trajectory data.

Accid Anal Prev 2020 Jul 9;144:105676. Epub 2020 Jul 9.

School of Traffic and Transportation Engineering, Central South University, Changsha, Hunan, 410075, PR China. Electronic address:

Time-to-collision (TTC) index has been extensively utilized to evaluate rear-end collision risks, but few studies have focused on the special transition process that vehicles change from a safe to a dangerous situation. This study conducts an in-depth analysis of the transition condition of rear-end collisions. Realistic vehicle trajectory data were extracted from the Federal Highway Administration's Next Generation Simulation (NGSIM) datasets. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105676DOI Listing

Long Noncoding RNA Hypoxia-Inducible Factor-1 Alpha-Antisense RNA 1 Regulates Vascular Smooth Muscle Cells to Promote the Development of Thoracic Aortic Aneurysm by Modulating Apoptotic Protease-Activating Factor 1 and Targeting let-7g.

J Surg Res 2020 Jul 9;255:602-611. Epub 2020 Jul 9.

Department of Cardiac Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China. Electronic address:

Background: Thoracic aortic aneurysm (TAA) is a severe threat that is characterized by the increased aortic diameter. The dysfunction of vascular smooth muscle cells (VSMCs) contributes to the formation of TAA. Previous research indicated that long noncoding RNAs (lncRNAs) were involved in the development of TAA. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.063DOI Listing

Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima.

Neurobiol Dis 2020 Jul 9:105013. Epub 2020 Jul 9.

Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, Hunan, China; Hunan Key Laboratory of Medical Genetics, Central South University, Changsha 410078, Hunan, China; Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha 410078, Hunan, China. Electronic address:

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by expansion of CGG repeats in the 5' UTR of the fragile X mental retardation 1 (FMR1) gene. Using the well-established FXTAS Drosophila model, we performed a high-throughput chemical screen using 3200 small molecules. NSC363998 was identified to suppress the neurodegeneration caused by riboCGG (rCGG) repeats. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.105013DOI Listing

Viral shedding dynamics in asymptomatic and mildly symptomatic patients infected with SARS-CoV-2.

Clin Microbiol Infect 2020 Jul 9. Epub 2020 Jul 9.

Chongqing University Central Hospital (W Li,S Zhi, J Huang, W Bai, Y Ma). Electronic address:

Objectives: Asymptomatic patients, together with those with mild symptoms of COVID-19, may play an important role in SARS-CoV-2 transmission. However, the dynamics of viral shedding during the various phases of the clinical course of COVID-19 remains unclear at this stage.

Methods: A total of 18 patients found positive for SARS-CoV-2 infection by real-time reverse transcription PCR (RT-PCR) assay, and admitted to Chongqing University Central Hospital between Jan 29 and Feb 5 were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.07.008DOI Listing
July 2020
5.768 Impact Factor

Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities.

Bioorg Chem 2020 Jun 30;102:104061. Epub 2020 Jun 30.

Department of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:

Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an extensive range of biological activities. However, the antidiabetic mechanism of poncirin is unexplored yet. In this study, we examined the anti-diabetic prospective of poncirin by evaluating its ability to inhibit protein tyrosine phosphatase 1B (PTP1B), α-glucosidase, human recombinant AR (HRAR), rat lens aldose reductase (RLAR), and advanced glycation end-product (AGE) formation (IC = 7. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104061DOI Listing

The voltage-gated potassium channel K1.3 as a therapeutic target for venom-derived peptides.

Biochem Pharmacol 2020 Jul 9:114146. Epub 2020 Jul 9.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia; ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia. Electronic address:

The voltage-gated potassium channel K1.3 is a well-established therapeutic target for a range of autoimmune diseases, in addition to being the site of action of many venom-derived peptides. Numerous studies have documented the efficacy of venom peptides that target K1. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114146DOI Listing

Circadian clock components Bmal1 and Clock1 regulate tlr9 gene expression in the Japanese medaka (Oryzias latipes).

Fish Shellfish Immunol 2020 Jul 9. Epub 2020 Jul 9.

Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen kibanadai-nishi, Miyazaki, 889-2192, Japan. Electronic address:

Currently, circadian regulation of immune molecules in lower vertebrates, particularly, diurnal oscillation in the immune status of a fish, is not well understood. In this study, the diurnal oscillation of toll-like receptor (Tlr) 9, which plays a role in pathogen recognition, was investigated in the Japanese medaka fish (Oryzias latipes). We confirmed the expression of tlr9 and clock genes (bmal1 and clock1) in the central and peripheral tissues of medaka. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.07.009DOI Listing
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