975,397 results match your criteria Central Cord Syndrome
Blood Purif 2018 Dec 6:1-6. Epub 2018 Dec 6.
Renal Research Institute, New York, New York, USA.
Background: The time between the creation of an arteriovenous fistula (AVF) and its successful use is significantly longer in hemodialysis (HD) patients in the United States compared to those in other countries, and there is an urgent need to reduce the residence time of central-venous catheters (CVC).
Methods: Successful AVF creation and maturation results in typical hemodynamic changes, such as an increase in cardiac output and upper body blood flow (UBBF). In patients with CVC as vascular access, we measured once per minute intradialytic central-venous oxygen saturation (ScvO2) and hemoglobin levels simultaneously using the Crit-Line Monitor. Read More
Blood Purif 2018 Dec 6:1-8. Epub 2018 Dec 6.
Renal Research Institute, New York, New York,
Background: Central venous oxygen saturation (ScvO2) is correlated with cardiac output. In most patients, ScvO2 declines during hemodialysis (HD) due to factors such as reduced preload, myocardial stunning, and intermittent arrhythmias. Previous research has shown that low ScvO2 is associated with higher mortality in chronic HD patients. Read More
Curr Opin Cell Biol 2018 Dec 3;57:57-63. Epub 2018 Dec 3.
Institute of Pharmacology and Bio-Imaging Center, University of Würzburg, Germany.
G protein-coupled receptors (GPCRs) are among the best-studied membrane receptors, mainly due to their central role in human physiology, involvement in disease and relevance as drug targets. Although biochemical and pharmacological studies have characterized the main steps in GPCR signaling, how GPCRs produce highly specific responses in our cells remains insufficiently understood. New developments in single-molecule microscopy have made it possible to study the protein-protein interactions at the basis of GPCR signaling in previously inconceivable detail. Read More
Int J Surg Case Rep 2018 Nov 24;54:55-59. Epub 2018 Nov 24.
Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital - Faculty of Medicine Universitas, Jl. Pangeran Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia. Electronic address:
Introduction: Both gluteal abscess and sacral tuberculosis are rare entities in spinal tuberculosis cases. Even in endemic country, this atypical presentation may be the cause of delayed diagnosis and treatment.
Presentation Of Case: A 51-year-old woman was admitted with painless massive lump on both of her thighs that have been enlarging for the past 6 months. Read More
Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.
Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More
Midwifery 2018 Nov 19;69:163-171. Epub 2018 Nov 19.
Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address:
Objectives: Suboptimal breastfeeding contributes to morbidity and mortality in children. Studies in high-income countries (HICs) show that exclusive-breastfeeding (EBF) is associated with longer breastfeeding duration. The aim of this study was to determine whether maternal reports of EBF at six months are associated with longer duration of breastfeeding during the first two years of life in a low and middle-income country (LMIC) setting, and to identify determinants of breastfeeding duration. Read More
Midwifery 2018 Nov 28;69:150-157. Epub 2018 Nov 28.
School of Nursing, Midwifery and Paramedicine, Curtin University, Perth, Western Australia.
Objective: The objective of this study was to explore midwives' experiences of being 'with woman' in the intrapartum period within the context of an unknown midwife model.
Design: A descriptive phenomenological design was used with individual in-depth interviews. Transcribed interviews were analysed using thematic analysis that incorporated the data analysis framework offered by Amadeus Giorgi. Read More
Sci Total Environ 2018 Nov 23;656:458-467. Epub 2018 Nov 23.
Department of Hydrology, Faculty of Geography and Regional Studies, University of Warsaw, Krakowskie Przedmieście 30, 00-927 Warsaw, Poland. Electronic address:
Considering the growing recognition that human activity and climate variability are critical stressors influencing river regimes, there is an urgent need to identify the contribution of these fundamental factors. Here we examine the runoff changes of a wastewater-effluent dominated river flowing in a heavily modified urban environment. The study concerns the Utrata River basin (727 km), central Poland, a challenging human-natural system for investigating changes in hydrological processes. Read More
Psychoneuroendocrinology 2018 Nov 30;102:63-67. Epub 2018 Nov 30.
Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, D-54290, Trier, Germany. Electronic address:
Secretion of the stress hormone cortisol follows a circadian rhythm and is stimulated following stress exposure. Cortisol regulates the transcription of several genes, primarily through activation of the glucocorticoid receptor (GR). Previously, we showed an upregulation of PERIOD genes PER1 and PER3 after pharmacological/glucocorticoid challenge in vivo and in vitro. Read More
Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.
Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More
Int Immunopharmacol 2018 Dec 3;66:347-353. Epub 2018 Dec 3.
Department of orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China. Electronic address:
Ivabradine is most commonly used for the treatment of worsening cardiac failure in patients who cannot tolerate the maximum dose of β-blockers or in whom treatment with β-blockers is contraindicated. While ivabradine is regarded as a highly selective "funny current" (I) inhibitor, the molecular mechanism behind the effect of this drug remains poorly understood. In the present study, we applied ivabradine in the context of osteoarthritis by treating primary human chondrocytes with tumor necrosis factor-α (TNF-α) and measuring degradation of the articular cartilage matrix as well as the expression of various enzymes and pro-inflammatory cytokines. Read More
World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS).
Objective: This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for symptomatic LGS.
Methods: Study participants comprised 61 consecutive patients who underwent CEA for symptomatic carotid stenosis. Read More
Neurosci Lett 2018 Dec 3. Epub 2018 Dec 3.
Department of Anesthesiology, Tianjin First Central Hospital, Tianjin 300192, China. Electronic address:
Background: Iron is pivotal for life, but it is toxic if in excess. Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases. Chemokine-induced neuroinflammation involves the development of pathological pain. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Middle East Technical University (METU), BIOMATEN Center of Excellence in Biomaterials and Tissue Engineering, Ankara 06800, Turkey; Middle East Technical University (METU), Graduate Department of Micro and Nanotechnology, Ankara 06800, Turkey; Middle East Technical University (METU), Department of Chemistry, Ankara 06800, Turkey. Electronic address:
Poly(ε-caprolactone) (PCL) is one of the most commonly used polymers in the production of tissue engineered scaffolds for hard tissue treatments. Incorporation of cells into these scaffolds significantly enhances the healing rate of the tissue. In this study, PCL scaffolds were prepared by wet spinning technique and modified by addition of fibrinogen in order to form a fibrin network between the PCL fibers. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Computation and Simulation Unit (Analytical and Environmental Science Division and Centralized Instrument Facility), CSIR-Central Salt & Marine Chemicals Research Institute, India; Academy of Scientific and Innovative Research, CSIR-CSMCRI, Bhavnagar, Gujarat 364 002, India. Electronic address:
Search for inhibitors to stabilize the telomeric G-quadruplex in order to deter telomerase activity is an active area of research. Inhibitors play an important role to initiate the tumor cell mortalization process. This work reports for the first time of acridine derivative with four membered ammonium rings at the side chain to surpass the binding ability against BRACO-19 with G-quadruplex-DNA. Read More
Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.
Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address:
Immunotherapy through immune checkpoint blockers (ICBs) is quickly transforming cancer treatment by improving patients' outcomes. However, innate and acquired resistance to ICBs remain a major challenge in clinical settings. Indoleamine 2,3-dioxygenases (IDOs) are enzymes involved in tryptophan catabolism with a central immunosuppressive function within the tumor microenvironment. Read More
Cell Signal 2018 Dec 3. Epub 2018 Dec 3.
Division of Cell Matrix Biology & Regenerative Medicine, UK. Electronic address:
Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark of early photodamage and that these ECM assemblies are susceptible in vitro to physiologically attainable doses of ultraviolet radiation (UVR). Here, we test the hypotheses that UVR-mediated photo-oxidation is the primary driver of fibrillin microfibril and fibronectin degradation and that prior UVR exposure will enhance the subsequent proteolytic activity of UVR-upregulated matrix metalloproteinases (MMPs). Read More
J Neurosci Methods 2018 Dec 3. Epub 2018 Dec 3.
Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, USA; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA. Electronic address:
Background: Traditional methods to assess pain in rodents depend on measures of nociceptive responses, most commonly from the hind paws. While these measures can quantify nociceptive responses to allow pharmacologic testing, they typically have high inter-experimenter variability and are not time-sensitive enough to correct with neural processes that occur on millisecond scales.
New Method: We have invented a pain detection device that uses changes in skin conductance to measure nocifensive withdrawal responses. Read More
Dev Biol 2018 Dec 3. Epub 2018 Dec 3.
Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA USA.
Regenerative ability is highly variable among the metazoans. While many invertebrate organisms are capable of complete regeneration of entire bodies and organs, whole-organ regeneration is limited to very few species in the vertebrate lineages. Tunicates, which are invertebrate chordates and the closest extant relatives of the vertebrates, show robust regenerative ability. Read More
Acta Trop 2018 Dec 3. Epub 2018 Dec 3.
ICMR-National Institute of Malaria Research Field Unit Jablpur, Epidemiology, ICMR-NIRTH Campus, Nagpur Road, 482003, Jabalpur, Madhya Pradesh, India. Electronic address:
The cost burden of malaria at the household level, resulting from complex social, economic, and epidemiological factors, is enormous. This study was carried out to estimate the economic burden of malaria at the household level in low and high malaria transmission areas of central India. We conducted surveys with households in which at least one member had suffered from malaria in the three months preceding the survey. Read More
Brain Res 2018 Dec 3. Epub 2018 Dec 3.
Norwegian Center for Stem Cell Research, Oslo University Hospital, Norway. Electronic address:
The spinal locomotor central pattern generator (CPG) in neonatal mice exhibits diverse output patterns, ranging from sub-rhythmic to multi-rhythmic to fictive locomotion, depending on its general level of excitation and neuromodulatory status (Sharples and Whelan, 2017). We have recently reported that the locomotor CPG in neonatal mice rapidly recovers the ability to produce neurochemically induced fictive locomotion following an upper lumbar spinal cord compression injury (Züchner et al., 2018). Read More
J Invertebr Pathol 2018 Dec 3. Epub 2018 Dec 3.
Laboratory of Animal Pathology, Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal; University Institute of Health Sciences & Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central da Gandra no. 1317, 4585-116 Gandra, Portugal.
Three new types of sphaeractinomyxon (Cnidaria, Myxozoa) are described from the coelomic cavity of the marine oligochaete Tubificoides insularis, collected from the Alvor estuary, Algarve, Portugal. Another known type is also registered from this location and host: Sphaeractinomyxon type 10 of Rangel et al., 2016, which was originally described from the marine oligochaete Tubificoides pseudogaster in the Aveiro estuary, Portugal. Read More
J Pediatr (Rio J) 2018 Dec 3. Epub 2018 Dec 3.
Universidade Estadual Paulista, Departamento de Educação Física, Presidente Prudente, SP, Brazil. Electronic address:
Objective: Investigate the relationship between different domains of physical activity and resting heart rate (RHR) in boys and girls.
Method: The sample included 1011 adolescents, aged between 10 and 17 years. RHR was measured by a heart rate monitor and physical activity was assessed in total and in three different domains (school, occupational, and sports practice) by a questionnaire. Read More
Acta Ortop Mex 2018 May-Jun;32(3):167-171
Departamento de Piel y Partes Blandas del Instituto Nacional de Cancerología. Ciudad de México, México.
Dedifferentiated parosteal osteosarcoma is a variant in which a high grade osteosarcoma coexists with a parosteal osteosarcoma. We report the case of a 20-year-old female patient who presented with six months of evolution of pain and functional limitation of the right forearm, with no apparent cause; radiographs were performed, observing a tumoral lesion in the diaphysis of the right ulna. Physical examination showed pain upon palpation in the diaphysis of the ulna and limitation of prone-supination. Read More
Acta Ortop Mex 2018 May-Jun;32(3):131-133
Clínica de Detección y Diagnóstico Automatizado, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Ciudad de México.
Background: Osteoporosis is a public health problem worldwide, affecting more than 200 million people. It is estimated that 30 to 50% of postmenopausal women suffer from it. According to the International Osteoporosis Foundation (IOF), osteoporosis is a disease characterized by a decrease in the density and quality of bones. Read More
Cochrane Database Syst Rev 2018 Dec 5;12:CD009269. Epub 2018 Dec 5.
BC Centre on Substance Use, BC Centre for Excellence in HIV/AIDS, 611 Powell Street, Vancouver, BC, Canada, V6A 1H2.
Background: Problem alcohol use is common among people who use illicit drugs (PWID) and is associated with adverse health outcomes. It is also an important factor contributing to a poor prognosis among drug users with hepatitis C virus (HCV) as it impacts on progression to hepatic cirrhosis or opioid overdose in PWID.
Objectives: To assess the effectiveness of psychosocial interventions to reduce alcohol consumption in PWID (users of opioids and stimulants). Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD011644. Epub 2018 Dec 3.
Sheila Sherlock Liver Centre, Royal Free Hospital and the UCL Institute of Liver and Digestive Health, London, UK.
Background: Hepatitis C virus (HCV) is a single-stranded RNA (ribonucleic acid) virus that has the potential to cause inflammation of the liver. The traditional definition of acute HCV infection is the first six months following infection with the virus. Another commonly used definition of acute HCV infection is the absence of HCV antibody and subsequent seroconversion (presence of HCV antibody in a person who was previously negative for HCV antibody). Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD012624. Epub 2018 Dec 3.
Department of Surgery and Anaesthesia, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Uttoxeter New Road, Derby, UK, DE22 3DT.
Background: Postoperative pain is a common consequence of surgery and can have deleterious effects. It has been suggested that the administration of opioid analgesia before a painful stimulus may improve pain control. This can be done in two ways. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013186. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013189. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013187. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management, reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin but has potential to infiltrate and damage surrounding tissue, while cutaneous squamous cell carcinoma (cSCC) and melanoma have a much higher potential to metastasise and ultimately lead to death. Exfoliative cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013191. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is important to guide appropriate management and improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damage surrounding tissue, whereas cutaneous squamous cell carcinoma (cSCC) and melanoma are higher risk skin cancers with the potential to metastasise and ultimately lead to death. When used in conjunction with clinical or dermoscopic suspicion of malignancy, or both, reflectance confocal microscopy (RCM) may help to identify cancers eligible for non-surgical treatment without the need for a diagnostic biopsy, particularly in people with suspected BCC. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013193. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013192. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for most skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and potentially offer an instant risk assessment of the likelihood of malignancy so that the right people seek further medical attention from a clinician for more detailed assessment of the lesion. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013194. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious lesion by a clinician is usually the first in a series of 'tests' to diagnose skin cancer. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013188. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early, accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers with the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD011902. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013190. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving survival; however, anxiety around missing early cases needs to be balanced against appropriate levels of referral and excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.
School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.
Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More