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Int Med Case Rep J 2021 4;14:381-384. Epub 2021 Jun 4.

Department of Infectious Diseases, Saint Vincent Hospital, Worcester, MA, 01608, USA.

Lower extremity soft-tissue lesions are frequently encountered in clinical practice. Cellulitis, osteomyelitis, and diabetic foot ulcerations remain the top differentials. The acuity of illness, imaging studies, and deep wound cultures are helpful in most cases. Read More

Ocul Immunol Inflamm 2021 Jun 10:1-4. Epub 2021 Jun 10.

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

: To present a case of orbital fungal infection caused by a rare fungus, Lichtheimia corymbifera (Absidia corymbifera) in an immunocompetent individual.: A retrospective case study.: A 23-year-old male presented with painful proptosis of the right eye for 3 months. Read More

J Vet Diagn Invest 2021 Jun 10:10406387211022298. Epub 2021 Jun 10.

BluePearl Pet Hospital, Auburn Hills, MI, USA.

A 15-y-old castrated male Maine Coon cat was evaluated for an ulcerated soft tissue mass on the right hindlimb that had been observed for 4 mo and had grown rapidly. A 3 × 3 cm soft, raised, amorphous, and ulcerated subcutaneous mass was observed on the lateral right metatarsus. In-house cytology via fine-needle aspiration was nondiagnostic. Read More

J Adv Pract Oncol 2021 Mar 1;12(2):174-187. Epub 2021 Mar 1.

University of Applied Sciences for Health Professions Upper Austria, Steyr, Austria.

Background: Patient-reported outcome measures are measures of patients' health-related quality of life. They should be added to other lymphedema measurements. With an improved disease-free survival of secondary lower limb lymphedema, attention must focus on such assessments. Read More

Neuroophthalmology 2021 1;45(2):131-138. Epub 2021 Mar 1.

Department of Internal Medicine, Wright State University School of Medicine, Dayton, Ohio, USA.

Horner's syndrome coexisting with an ipsilateral fourth cranial nerve palsy is a rare occurrence and likely localises to pathology in the cavernous sinus. One such case may have occurred in the 18 century affecting the renowned mathematician Leonhard Euler. A review of his biographies, eulogies, and three finely detailed facial portraits suggest that these two neuro-ophthalmic conditions, along with visual loss and a decades-long intermittent febrile illness, may have been the result of an orbital cellulitis and septic cavernous sinus thrombosis, from an underlying chronic brucellosis infection. Read More

J Surg Case Rep 2021 Jun 4;2021(6):rjab227. Epub 2021 Jun 4.

Division of Plastic Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Primary cutaneous diffuse large B-cell lymphoma, leg type, accounts for only 4% of all cutaneous lymphomas and bears a worse prognosis than other cutaneous B-cell lymphomas. Diagnosis at an early stage may be difficult due to its nonspecific manifestations. We report an 88-year-old female who was brought to our emergency department due to two rapidly growing painful skin lesions with local redness and swelling on her right lower leg. Read More

Transplant Cell Ther 2021 Jun 5. Epub 2021 Jun 5.

Janssen Pharmaceutical K.K., Tokyo, Japan.

Background: Chronic graft-versus-host disease (cGVHD) is a serious complication after allogeneic stem cell transplantation. There are no well-established treatment options for cGVHD after primary steroid-based treatment. Ibrutinib showed clinical benefit with an acceptable safety profile in steroid-dependent/refractory cGVHD patients in a Phase 1b/2 study (PCYC-1129-CA, NCT02195869), with which it was approved in the United States for adult cGVHD patients after failure of ≥1 systemic treatments. Read More

Am J Ophthalmol Case Rep 2021 Jun 16;22:101092. Epub 2021 Apr 16.

Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Purpose: Rhino-orbital-cerebral mucormycosis (ROCM) is a rare opportunistic infection with a high mortality despite relevant treatment.

Observations: A 3-year-old girl under treatment for acute lymphoblastic leukemia developed periorbital swelling, ophthalmoplegia and a necrotic palatal lesion during a period of neutropenia. Imaging revealed sinusitis, pre- and postseptal cellulitis. Read More

Eur J Cancer 2021 Jul 20;151:233-244. Epub 2021 May 20.

Department of Plastic Surgery, The Royal Marsden NHS Foundation Trust, London, UK. Electronic address:

Background: Lymphoedema after cancer treatment is a chronic and disabling complication that presents a significant health care burden during survivorship with limited treatment options. Vascularised lymph node transfer (VLNT) can reconstruct lymphatic flow to reduce limb volumes, but limited higher-order evidence exists to support its effectiveness.

Aim: The aim of the study was to systematically review and meta-analyse the effectiveness of VLNT in reducing upper limb (UL) or lower limb (LL) volume and cellulitis episodes in patients with cancer treatment-related lymphoedema (CTRL). Read More

Arch Soc Esp Oftalmol (Engl Ed) 2021 Jun 27;96(6):288-292. Epub 2021 Feb 27.

Hospital de San Juan de Dios, Santiago, Chile.

Objective: To establish the success rate of salvage intra-arterial chemotherapy (IAC), defined as the percentage of eyes that achieved tumoral remission and avoided enucleation. The second objective was the clinical characterization, catheterization results, and associated local and systemic complications.

Methods: Retrospective, interventional case series of 29 patients (35 eyes) with persistent or recurrent retinoblastoma. Read More

Medicine (Baltimore) 2021 Jun;100(22):e26118

Department of Emergency Medicine and Laboratory of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Liuhedan is a famous traditional Chinese Medicine formula used to treat cellulitis in China. However, there are no systematic reviews for the evidence and the therapeutic effectiveness and safety of Liuhedan for treating cellulitis. The aim of this study is to summarize previous evidence, assessing the efficacy and safety of Liuhedan treating cellulitis. Read More

J Pharm Pract 2021 Jun 3:8971900211021258. Epub 2021 Jun 3.

Department of Pharmacy, 532836Huntsville Hospital, Huntsville, AL, USA.

Background: Shifting inpatient antibiotic treatment to outpatient parenteral antimicrobial therapy may minimize treatment for acute bacterial skin and skin structure infections, including cellulitis. The purpose of this evaluation was to compare 30-day hospital readmission or admission due to cellulitis and economic outcomes of inpatient standard-of-care (SoC) management of acute uncomplicated cellulitis to outpatient oritavancin therapy.

Methods: This retrospective, observational cohort study was conducted at a 941-bed community teaching hospital. Read More

Ann Dermatol 2021 Jun 4;33(3):281-283. Epub 2021 May 4.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

In Asian countries, acupuncture with gold threads has been widely used in the treatment of pain. However, several reports have suggested that the implanted gold threads can become fragmented and migrate to other parts of the body, damaging surrounding tissues. A 75-year-old female presented with diffuse erythematous edema with multiple vesicles on the right lower leg for 3 days. Read More

Orbit 2021 Jun 2:1-5. Epub 2021 Jun 2.

Department of Ophthalmology, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.

Orbital metastasis of urothelial carcinoma is very rare; only 22 cases have been documented. In this case report, we describe a patient 1 month status post transurethral resection of urothelial carcinoma who presented with a clinical picture suggestive of orbital cellulitis. However, neither broad-spectrum antibiotics nor a subsequent trial of methylprednisolone was effective at relieving the patient's symptoms. Read More

Bol Med Hosp Infant Mex 2021 Jun 2. Epub 2021 Jun 2.

Clínicas Pediátricas, Facultad de Medicina, Universidad de la República; Hospital Pediátrico, Centro Hospitalario Pereira Rossell. Montevideo, Uruguay.

Background: Myiasis is an emerging disease caused by tissue invasion of dipteran larvae. In Uruguay, Cochliomyia hominivorax and Dermatobia hominis are the most frequent species. This study aimed to describe the epidemiological and clinical characteristics and the follow-up of children < 15 years hospitalized for myiasis in a reference center in Uruguay between 2010 and 2019. Read More

J Pers Med 2021 May 12;11(5). Epub 2021 May 12.

Division of Plastic and Reconstructive Surgery, Department of Medical and Surgical Sciences, Modena Policlinico Hospital, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Breast cancer-related lymphedema (BCRL) represents a global healthcare issue affecting the emotional and life quality of breast cancer survivors significantly. The clinical presentation is characterized by swelling of the affected upper limb, that may be accompanied by atrophic skin findings, pain and recurrent cellulitis. Cardinal principles of lymphedema management are the use of complex decongestive therapy and patient education. Read More

Int J Environ Res Public Health 2021 May 11;18(10). Epub 2021 May 11.

National Red Imported Fire Ant Control Center, Council of Agriculture, Executive Yuan, Taipei 10617, Taiwan.

The first report of the red imported fire ant (RIFA), Buren, in Taiwan was in the city of Taoyuan in 2003. The government has made great efforts to bring RIFA-infested areas under control. RIFA has gradually spread outward since its discovery, but it is still confined in northern Taiwan, in part due to the control efforts. Read More

NASN Sch Nurse 2021 Jun 1:1942602X211019109. Epub 2021 Jun 1.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine, Attending Pediatric Emergency Medicine physician, Penn State Hershey Medical Center, Hershey, PA.

School nurses may deal with various common infectious eye, ear, nose, and throat-related chief complaints in regular practice. Recognizing the signs and symptoms of severe infection is paramount to preventing life-threatening complications that can have both acute and long-term implications. Distinguishing urgent and emergent eye, ear, nose, and throat conditions to send to the emergency department is integral to reducing the morbidity associated with these conditions. Read More

Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S108-S115

Neuroradiology Department, Nuovo Ospedale Civile Sant'Agostino Estense, Modena, Italy.

Med Clin North Am 2021 Jul;105(4):723-735

Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, 2nd Floor, Boston, MA 02114, USA. Electronic address:

Cellulitis is a common skin infection resulting in increasing hospitalizations and health care costs. There is no gold standard diagnostic test, making cellulitis a potentially challenging condition to distinguish from other mimickers. Physical examination typically demonstrates poorly demarcated unilateral erythema with warmth and tenderness. Read More

Ann R Coll Surg Engl 2021 Jun;103(6):e199-e201

St Thomas' Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

The management of dissecting scalp cellulitis involves medical treatment with oral antibiotics and isotretinoin, as well as surgical input in more severe cases. In extensive disease, a full scalpectomy with reconstruction can be required. We report a case of severe dissecting scalp cellulitis in a 34-year-old man who underwent serial scalp excisions over three years, with wounds being left to heal by secondary intention. Read More

J Pak Med Assoc 2021 Mar;71(3):1011-1013

Department of Surgery, Aga Khan University, Karachi, Pakistan.

Pregnancy is associated with a wide variety of oral and dental changes ranging from gingivitis to odontogenic infections. If left untreated, severe dental abscess can progress to Ludwig's angina, which is a potentially lethal cellulitis that rapidly extends to the neck region and may lead to life-threatening upper airway obstruction. We report the case of a pregnant woman who presented with intense throbbing pain, trismus and severely reduced mouth opening due to dental abscess for the last one week. Read More

Jpn J Ophthalmol 2021 May 31. Epub 2021 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Kayseri City Training and Research Hospital, University of Health Science, Kayseri, Turkey.

Purpose: To present the different clinical manifestations of rhino-orbital mucormycosis (ROM) co-infection in severe COVID-19 patients.

Study Design: Prospective observational clinical study METHODS: Among 32,814 patients hospitalized with the diagnosis of COVID-19 between March 2020 and December 2020 in our center, eleven microbiologically confirmed ROM co-infection cases in severe COVID-19 patients were evaluated.

Results: There were nine men and two women with a mean age of 73. Read More

Int J Low Extrem Wounds 2021 May 31:15347346211023030. Epub 2021 May 31.

13622JR Tokyo General Hospital, Tokyo, Japan.

Lymphedema is a chronic edema that sometimes occurs after treatment of gynecologic cancer, and cellulitis often occurs concomitantly with lymphedema. On the other hand, necrotizing fasciitis (NF) is a relatively rare, but life-threatening disease. The symptoms in cellulitis and NF are very similar. Read More

Int J Dermatol 2021 May 31. Epub 2021 May 31.

Mayo Clinic, Rochester, MN, USA.

Background: Intravascular histiocytosis is an underrecognized reactive skin condition characterized by the clinical finding of poorly demarcated erythematous to violaceous patches and plaques. The diagnosis is confirmed by the histologic findings of intraluminal histiocytes on skin biopsy and exclusion of an alternative diagnosis.

Methods: A review of patients with a histologic diagnosis of intravascular or intralymphatic histiocytosis and seen at Mayo Clinic, Rochester, Minnesota, from January 1, 2010, to October 10, 2020, was performed. Read More

J Clin Aesthet Dermatol 2021 Apr 1;14(4):E61-E67. Epub 2021 Apr 1.

Dr. Umar is with the Department of Medicine at the University of California at Los Angeles in Los Angeles, California; the Division of Dermatology, Harbor-UCLA Medical Center in Torrance, California; and the Dr. U Hair and Skin Clinic in Manhattan Beach, California.

Although many treatments are available for acne keloidalis nuchae (AKN), no systematic classification scheme exists to evaluate the outcomes of these treatments. This study aimed to propose an AKN classification scheme. A retrospective data analysis of several parameters, including lesion distribution, lesion type, and scalp disease association, was conducted in 108 men diagnosed with AKN between July 2009 and November 2020 in an outpatient dermatology setting. Read More

Case Rep Ophthalmol 2021 Jan-Apr;12(1):270-276. Epub 2021 Apr 19.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

We reported a case of upper eyelid necrosis initially misdiagnosed as a preseptal cellulitis following a hordeolum externum resulting in great damage to the upper eyelid (anterior lamella). The infection was successfully treated with surgical cleansing, drainage, and endovenous antibiotics. Early treatment may avoid severe complications such as eyelid deformity, systemic involvement, and blindness. Read More

Am Surg 2021 May 29:31348211023392. Epub 2021 May 29.

Division of Hepatopancreaticobiliary Surgery, Department of Surgery, 22442Atrium Health-Carolinas Medical Center, Charlotte, NC, USA.

Background: Abdominal wall reconstruction in high-risk and contaminated cases remains a challenging surgical dilemma. We report long-term clinical outcomes for a rifampin-/minocycline-coated acellular dermal graft (XenMatrix™ AB) in complex abdominal wall reconstruction for patients with a prior open abdomen or contaminated wounds.

Methods: Patients undergoing abdominal wall reconstruction at our institution at high risk for surgical site occurrence and reconstructed with XenMatrix™ AB with intent-to-treat between 2014 and 2017 were included. Read More

Int J Surg Case Rep 2021 May 15;83:105988. Epub 2021 May 15.

Mohammed First University, Faculty of Medicine and Pharmacy, Oujda, Morocco; University Hospital Center Mohamed VI, Oujda, Morocco.

Introduction: The internal jugular vein thrombosis is usually due to intravenous drug abuse, prolonged central venous catheterization or deep head-neck infections or trauma. Related malignancies, or inflammatory etiologies are described. Our case is interesting by the ingestion of a sewing needle that passes from the pharynx to the internal jugular vein via migration, leading to life-threatening complications: deep neck space infection and internal jugular vein thrombosis. Read More

Klin Lab Diagn 2021 May;66(5):310-314

Ivanovo State Medical Academy.

The aim of the study was to assess the informative value of volatile fatty acid parameters for the differential diagnosis of infected pancreatic necrosis (IPN), complicated by retroperitoneal cellulitis. The work was based on the results of examination and treatment of 44 patients with infected pancreatic necrosis. The analysis of concentrations of volatile fatty acids: acetic, propionic, butyric and isovalerianic was carried out on a Kristallux-4000 automated gas chromatograph with an HP-FFAP capillary column and a flame ionization detector. Read More