5,157 results match your criteria Cellular signalling[Journal]


MeCP2 inactivation of LncRNA GAS5 triggers cardiac fibroblasts activation in cardiac fibrosis.

Cell Signal 2020 Jul 4:109705. Epub 2020 Jul 4.

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Long non coding RNA growth arrest-specific transcript 5 (LncRNA GAS5) participate in the formation of fibrosis diseases. However, the key role of LncRNA GAS5 in the development of cardiac fibrosis remains unclear. Accumulating evidence suggests that DNA methylation alterations play a central role in cardiac fibroblast activation. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109705DOI Listing

Janus sword actions of chloroquine and hydroxychloroquine against COVID-19.

Cell Signal 2020 Jul 3:109706. Epub 2020 Jul 3.

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, United States of America.

Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have been thrust into our everyday vernacular because some believe, based on very limited basic and clinical data, that they might be helpful in preventing and/or lessening the severity of the pandemic coronavirus disease 2019 (COVID-19). However, lacking is a temperance in enthusiasm for their possible use as well as sufficient perspective on their effects and side-effects. CQ and HCQ have well-known properties of being diprotic weak bases that preferentially accumulate in acidic organelles (endolysosomes and Golgi apparatus) and neutralize luminal pH of acidic organelles. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333634PMC

Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease.

Cell Signal 2020 Jul 1:109704. Epub 2020 Jul 1.

Division of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada. Electronic address:

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic kidney disease worldwide and an important cause of chronic kidney disease. Multiple experimental studies have highlighted the role of increased mammalian target of rapamycin complex 1 (mTORC1) and reduced AMP-activated protein kinase (AMPK) signaling in modulating cyst growth in ADPKD. Notably, mTORC1 and AMPK are two diametrically opposing sensors of energy metabolism which regulate cell growth and proliferation. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109704DOI Listing

Targeting chloride transport in autosomal dominant polycystic kidney disease.

Cell Signal 2020 Jun 30;73:109703. Epub 2020 Jun 30.

Division of Nephrology, UCLouvain Medical School, B-1200, Brussels, Belgium,; Mechanisms of Inherited Kidney Disorders, University of Zurich, CH-8057 Zurich, Switzerland. Electronic address:

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent inherited kidney disease. Transepithelial fluid secretion is one of the key factors of cystogenesis in ADPKD. Multiple studies have suggested that fluid secretion across ADPKD cyst-lining cells is driven by the secretion of chloride, essentially mediated by the CFTR channel and stimulated by increased intracellular levels of 3',5'-cyclic adenosine monophosphate. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109703DOI Listing

TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation.

Cell Signal 2020 Jun 30;73:109702. Epub 2020 Jun 30.

Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Key laboratory of Animal Breeding and Reproduction, Nanjing 210014, China. Electronic address:

Lipopolysaccharide (LPS) is an inhibitory factor that causes hormonal imbalance and subsequently affects ovarian function and fertility in mammals. Previous studies have shown that the exposure of granulosa cells (GC) to LPS leads to steroidogenesis dysfunction. However, the effects of LPS on the viability of GC remain largely unclear. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109702DOI Listing

Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.

Cell Signal 2020 Jun 26:109693. Epub 2020 Jun 26.

Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:

Non-small-cell lung cancer (NSCLC) is one of the most common solid tumors and the leading cause of lung cancer-related fatality. Growing evidence has indicated that circular RNAs (circRNAs) play important roles in the progression of multiple human cancers. As a novel circRNA, very little research has focused on the function of circRNA TUBA1C (circTUBA1C) in cancer development, including NSCLC. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109693DOI Listing

Silence of lncRNA MIAT-mediated inhibition of DLG3 promoter methylation suppresses breast cancer progression via the Hippo signaling pathway.

Cell Signal 2020 Jun 25:109697. Epub 2020 Jun 25.

Department of Oncology, North Sichuan Medical College Affiliated Nanchong Central Hospital, Nanchong 637000, China.

As the foremost common female malignancy, breast cancer (BC) poses a significant public health stumbling block. Although treatment protocols have improved over the years, the overall prognosis of BC remains unsatisfactory. Extensive investigations have taken place into long non coding RNAs (lncRNAs) pertaining to their involvement in carcinogenesis. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109697DOI Listing

Signaling pathways that control mRNA translation initiation in macrophages.

Cell Signal 2020 Jun 25;73:109700. Epub 2020 Jun 25.

Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA. Electronic address:

Translational control in mammalian cells plays a critical role in regulating differentiation, cell growth, cell cycle and response to diverse stresses. Macrophages are one of the most versatile cell types in the body. They are professional phagocytic cells that can be found in almost all tissues and adapt tissue-specific functions. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109700DOI Listing

Unfolded protein response in cardiovascular disease.

Cell Signal 2020 Jun 25;73:109699. Epub 2020 Jun 25.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA. Electronic address:

The unfolded protein response (UPR) is a highly conserved molecular machinery, which protects the cells against a diverse variety of stimuli. Activation of this element has been associated with both human health and disease. The purpose of the current manuscript is to provide the most updated information on the involvement of UPR towards the improvement; or deterioration of cardiovascular functions. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109699DOI Listing

Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease.

Cell Signal 2020 Jun 20;73:109698. Epub 2020 Jun 20.

Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address:

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic diseases implicated in the development of end stage renal disease (ESRD). Although FDA has recently approved a drug against ADPKD, there is still a great need for development of alternative management strategies for ADPKD. Understanding the different mechanisms that lead to cystogenesis and cyst expansion in ADPKD is imperative to develop new therapies against ADPKD. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109698DOI Listing

LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2.

Cell Signal 2020 Jun 18:109695. Epub 2020 Jun 18.

Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, Guangdong, China. Electronic address:

Illuminating the mechanisms of odontoblast differentiation of human dental pulp stem cells (hDPSCs) is the key to find therapeutic clues to promote odontogenesis. LncRNAs play a regulatory role in odontoblast differentiation. Here, we identified a novel lncRNA, named lncRNA CALB2. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109695DOI Listing

Characteristics of circular RNAs generated by human Survival Motor Neuron genes.

Cell Signal 2020 Jun 15;73:109696. Epub 2020 Jun 15.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States of America. Electronic address:

Circular RNAs (circRNAs) belong to a diverse class of stable RNAs expressed in all cell types. Their proposed functions include sponging of microRNAs (miRNAs), sequestration and trafficking of proteins, assembly of multimeric complexes, production of peptides, and regulation of transcription. Backsplicing due to RNA structures formed by an exceptionally high number of Alu repeats lead to the production of a vast repertoire of circRNAs by human Survival Motor Neuron genes, SMN1 and SMN2, that code for SMN, an essential multifunctional protein. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109696DOI Listing
June 2020
4.315 Impact Factor

Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and death.

Cell Signal 2020 Jun 15;73:109690. Epub 2020 Jun 15.

Medicine/Cardiovascular Medicine, University of Missouri, Columbia, MO 65211, USA; Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA; Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA. Electronic address:

Minocycline, an FDA-approved second-generation semisynthetic tetracycline, exerts antioxidant, anti-apoptotic and anti-inflammatory effects, independent of its antimicrobial properties. Interleukin (IL)-17A is an immune and inflammatory mediator, and its sustained induction is associated with various cardiovascular diseases. Here we investigated (i) whether IL-17A induces cardiomyocyte contractile depression and death, (ii) whether minocycline reverses IL-17A's negative inotropic effects and (iii) investigated the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109690DOI Listing
June 2020
4.315 Impact Factor

CTRP9: An emerging potential anti-aging molecule in brain.

Cell Signal 2020 Jun 12;73:109694. Epub 2020 Jun 12.

Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

C1q/tumor necrosis factor (TNF)-related proteins (CTRPs) particularly CTRP9, have been established to be as adiponectin (APN) highly conserved paralogs which assemble several APN regulatory functions. Recently, growing body of evidences drawn significant attention to evaluate metabolic and cardiovascular effect of CTRP9. However, the potential role of CTRP9 in brain tissue has not yet fully illustrated. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109694DOI Listing
June 2020
4.315 Impact Factor

IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.

Cell Signal 2020 Jun 11;73:109692. Epub 2020 Jun 11.

Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire (IRIBHM), Université Libre de Bruxelles, Campus Erasme, 1070 Brussels, Belgium. Electronic address:

A tight control of the machineries regulating membrane bending and actin dynamics is very important for the generation of membrane protrusions, which are crucial for cell migration and invasion. Protein/protein and protein/phosphoinositides complexes assemble and disassemble to coordinate these mechanisms, the scaffold properties of the involved proteins playing a prominent role in this organization. The PI 5-phosphatase SHIP2 is a critical enzyme modulating PI(3,4,5)P, PI(4,5)P and PI(3,4)P content in the cell. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109692DOI Listing

Phosphorylation of the mRNA cap-binding protein eIF4E and cancer.

Cell Signal 2020 Jun 11;73:109689. Epub 2020 Jun 11.

Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA; Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

Dysregulated protein synthesis is frequently involved in oncogenesis and cancer progression. Translation initiation is thought to be the rate-limiting step in protein synthesis, and the mRNA 5' cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) is a pivotal factor that initiates translation. The activities of eIF4E are regulated at multiple levels, one of which is through its phosphorylation at Serine 209 by the mitogen-activated protein kinase-interacting kinases (MNKs, including MNK1 and MNK2). Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109689DOI Listing

MAP Kinase driven actomyosin rearrangement is a crucial regulator of monocyte to macrophage differentiation.

Cell Signal 2020 Jun 10;73:109691. Epub 2020 Jun 10.

Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India. Electronic address:

Rearrangement of actin cytoskeleton correlates significantly with the immune responses as the perturbation of cytoskeletal dynamics leads to many immune deficiencies. Mechanistic insights into this correlation remain unknown. Cellular spreading, the most characteristic phenotype associated with monocyte to macrophage differentiation, led us to investigate the contribution of actomyosin dynamics in monocyte differentiation. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109691DOI Listing
June 2020
4.315 Impact Factor

The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer.

Cell Signal 2020 Jun 5;73:109688. Epub 2020 Jun 5.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

Background: Gene and protein expression of the glucose transporter GLUT6 are elevated in multiple cancers, including endometrial cancer. However, the extrinsic and intrinsic mechanisms that regulate GLUT6 expression in this malignancy are unknown. Herein we investigate the potential mechanisms regulating GLUT6 expression in endometrial cancer. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109688DOI Listing

SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway.

Cell Signal 2020 Jun 3;73:109686. Epub 2020 Jun 3.

School of Bioengineering, Key Laboratory of Protein Modification and Disease, Liaoning Province, Dalian University of Technology, China. Electronic address:

In cancers, apoptosis evasion through dysregulation of pro-apoptotic and anti-apoptotic intracellular signals is a recurring event. Accordingly, selective inhibition of specific proteins represents an exciting therapeutic opportunity. Myeloid cell leukemia 1 (MCL1) is an anti-apoptotic protein of the BCL-2 family, which is overexpressed in many cancers. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109686DOI Listing
June 2020
4.315 Impact Factor

Role of HMGB1 signaling in the inflammatory process in diabetic retinopathy.

Authors:
Jena J Steinle

Cell Signal 2020 Jun 1;73:109687. Epub 2020 Jun 1.

Department of Ophthalmology, Visual, and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

High mobility group box 1 (HMGB1) is a key player in retinal inflammation. HMGB1 is a danger associated protein pattern receptor which can sense high glucose as a stressor. Increased HMGB1 levels have been found in patients with late stage diabetic retinopathy. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109687DOI Listing

MALAT1 overexpression promotes the growth of colon cancer by repressing β-catenin degradation.

Cell Signal 2020 May 30;73:109676. Epub 2020 May 30.

Department of Pathology, Qinghai University Affiliated Hospital, Xining, Qinghai 810001, China. Electronic address:

Colon cancer is one of the most common types of cancer and more than 80% of colon cancer cases are associated with Wnt-β-catenin signaling activation. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a multi-functional long non-coding RNA that is overexpressed in many types of cancers, including colon cancer. In this study, MALAT1 and β-catenin were found to be overexpressed in tumor samples from 62 patients with colon cancer. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109676DOI Listing

Functional characterization of neuropeptide 26RFa receptors GPR103A and GPR103B in zebrafish, Danio rerio.

Cell Signal 2020 May 26;73:109677. Epub 2020 May 26.

Institute of Biochemistry, College of Life Sciences, Zhejiang University, Zijingang Campus, Zhejiang, Hangzhou, 310058, China. Electronic address:

The hypothalamic neuropeptide 26RFa is the most recently identified member of the RFamide peptide family, and this 26RFa signaling system has been shown to be implicated in regulating a variety of physiological processes. In zebrafish,26RFa and two putative receptors, DrGPR103A and DrGPR103B, have been in silico identified, and in vivo data derived from overexpression and loss of function mutation experiments suggest the 26RFa signaling system plays an important role in the hypothalamic regulation of sleep. However, the biochemical and pharmacological information on DrGPR103A/B receptors is still unknown. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109677DOI Listing

The adaptor protein APS modulates BCR signalling in mature B cells.

Cell Signal 2020 May 26;73:109673. Epub 2020 May 26.

INSERM, U978, UFR SMBH, Bobigny, France; Comue USPC, Labex Inflamex, Université Paris 13, UFR SMBH, Bobigny, France. Electronic address:

Activation process of mature B cell is predominantly driven by specific BCR-mediated pathways, switched on and off all through late B cell differentiation stages. Mice deficient for APS, a member of the Lnk/SH2B family of adaptor proteins, showed that this adaptor plays a BCR-mediated regulatory role in mature B cells. However, the intermediates involved in this adaptor modulating functions in B cells are still unknown. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109673DOI Listing

MiR-210 in exosomes derived from CAFs promotes non-small cell lung cancer migration and invasion through PTEN/PI3K/AKT pathway.

Cell Signal 2020 May 21;73:109675. Epub 2020 May 21.

the First Department of Respiratory Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, China. Electronic address:

Objective: Cancer-associated fibroblasts (CAFs) function as a crucial factor in tumor progression by carrying exosomes to neighboring cells. This study was assigned to expound the underlying mechanism of CAFs-derived exosomal miR-210 in non-small cell lung cancer (NSCLC) progression.

Method: CAFs and normal fibroblasts (NFs) were isolated and identified. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109675DOI Listing
May 2020
4.315 Impact Factor

LncRNA XIST modulates 5-hydroxytrytophan-induced visceral hypersensitivity by epigenetic silencing of the SERT gene in mice with diarrhea-predominant IBS.

Cell Signal 2020 May 21;73:109674. Epub 2020 May 21.

Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, PR China. Electronic address:

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a prevalent gastrointestinal disorder with a high incidence in children. The role of long non-coding RNAs (lncRNAs) in gastrointestinal diseases has been previously highlighted. Nevertheless, the underlying regulatory mechanism of lncRNA X inactivate-specific transcript (XIST) in IBS-D requires further studies. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109674DOI Listing
May 2020
4.315 Impact Factor

CXCR4/MIF axis amplifies tumor growth and epithelial-mesenchymal interaction in non-small cell lung cancer.

Cell Signal 2020 May 16;73:109672. Epub 2020 May 16.

Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; German Center for Lung Research, BREATH, Hannover, Germany; Department of Pulmonology, Hannover Medical School, Hannover, Germany. Electronic address:

Overexpression of C-X-C chemokine receptor type 4 (CXCR4) has been shown in several cancers, including non-small cell lung cancer (NSCLC) and is linked to early metastasis and worse prognosis. The crosstalk between cancer cells and tumor stroma promotes the growth and metastasis and CXCR4 signaling is a key element of this crosstalk. To test the effects of CXCR4 overexpression (CXCR4-OE), we transduced the human NSCLC cell line A549 by using a lentiviral vector. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109672DOI Listing

Identification and characterization of tumorigenic circular RNAs in cervical cancer.

Cell Signal 2020 May 11;73:109669. Epub 2020 May 11.

Department of Gynaecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Circular RNAs (circRNAs) are a distinctive family of ncRNAs, and they function as key regulators in the initiation, development and progression of various diseases. However, the regulatory roles of circRNAs in the tumorigenesis of cervical cancer (CC) have not been fully understood. In this study, we identified a set of circRNAs in CC and paired normal tissues, using RNA sequencing data, and found that the cancer and normal tissues could be told apart by those differentially expressed (DE) circRNAs, indicating that circRNA expression profiles in CC were significantly different from those in the normal tissues. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109669DOI Listing

Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms.

Cell Signal 2020 Aug 8;72:109670. Epub 2020 May 8.

Department of Biotechnology, PSG College of Arts & Science, Civil Aerodrome Post, Coimbatore, Tamil Nadu 641 014, India. Electronic address:

Oxidative stress results from the imbalances in the development of reactive oxygen species (ROS) and antioxidants defence system resulting in tissue injury. A key issue resulting in the modulation of ROS is that it alters hosts molecular, structural and functional properties which is accomplished via various signalling pathways which either activate or inhibit numerous transcription factors (TFs). Some of the regulators include Nuclear erythroid-2 related factors (Nrf-2), CCAAT/enhancer-binding protein delta (CEBPD), Activator Protein-1 (AP-1), Hypoxia-inducible factor 1(HIF-1), Nuclear factor κB (NF-κB), Specificity Protein-1 (SP-1) and Forkhead Box class O (FoxO) transcription factors. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109670DOI Listing

Corrigendum to "Blue light-triggered photochemistry and cytotoxicity of retinal cellular signalling" [Volume 69 (2020), 109,547].

Cell Signal 2020 Aug 14;72:109667. Epub 2020 May 14.

Department of Chemistry and Biochemistry, The University of Toledo, Toledo, OH 43,606, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2020.109667DOI Listing
August 2020
4.315 Impact Factor

Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains.

Cell Signal 2020 May 13;73:109668. Epub 2020 May 13.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

The EphA2 receptor tyrosine kinase signals through two distinct mechanisms, one regulated by tyrosine phosphorylation and the other by serine/threonine phosphorylation. Serine 892 (S892) is one of the major serine/threonine phosphorylation sites in EphA2, but little is known about its regulation and function. S892 is located in the linker connecting the EphA2 kinase and SAM domains, and is part of a cluster of five phosphorylated residues that includes the well characterized S897. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109668DOI Listing

Roles for heterodimerization of APJ and B2R in promoting cell proliferation via ERK1/2-eNOS signaling pathway.

Cell Signal 2020 May 12;73:109671. Epub 2020 May 12.

Institute of Neurobiology, School of Mental Health, Jining Medical University, Jining 272067, PR China; Division of Translational and Systems Medicine, Warwick Medical School, University of Warwick, Coventry, UK. Electronic address:

Apelin receptor (APJ) and bradykinin B2 receptor (B2R) play an important role in many physiological processes and share multiple similar characteristics in distribution and functions in the cardiovascular system. We first identified the endogenous expression of APJ and B2R in human umbilical vein endothelial cells (HUVECs) and their co-localization on human embryonic kidney (HEK) 293 cells membrane. A suite of bioluminescence and fluorescence resonance energy transfer (BRET and FRET), proximity ligation assay (PLA), and co-immunoprecipitation (Co-IP) was exploited to demonstrate formation of functional APJ and B2R heterodimer in HUVECs and transfected cells. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109671DOI Listing

The role of miR-34c-5p/Notch in epithelial-mesenchymal transition (EMT) in endometriosis.

Cell Signal 2020 Aug 28;72:109666. Epub 2020 Apr 28.

Shengjing Hospital, China Medical University, Shenyang, Liaoning 110000, PR China. Electronic address:

Endometriosis, a common benign gynecological disease, has the growth characteristics of malignant tumors, however, the pathogenesis of this disease remains unclear. It is well known that micro ribonucleic acids (miRNAs) are involved in epithelial-mesenchymal transition (EMT), associated with the development of endometriosis. This study investigated the role of a specific miRNA, miR-34c-5p, in endometriosis. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109666DOI Listing

FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1.

Cell Signal 2020 Aug 28;72:109665. Epub 2020 Apr 28.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinicopathological characteristics in patients with NSCLCs. However, the role and potential molecular basis for FNDC5 in paclitaxel sensitivity of NSCLCs remain unclear. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109665DOI Listing

Modulation of polycystic kidney disease by G-protein coupled receptors and cyclic AMP signaling.

Cell Signal 2020 Aug 23;72:109649. Epub 2020 Apr 23.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disorder associated with polycystic liver disease (PLD) and other extrarenal manifestations, the most common monogenic cause of end-stage kidney disease, and a major burden for public health. Many studies have shown that alterations in G-protein and cAMP signaling play a central role in its pathogenesis. As for many other diseases (35% of all approved drugs target G-protein coupled receptors (GPCRs) or proteins functioning upstream or downstream from GPCRs), treatments targeting GPCR have shown effectiveness in slowing the rate of progression of ADPKD. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109649DOI Listing

c-Src kinase impairs the expression of mitochondrial OXPHOS complexes in liver cancer.

Cell Signal 2020 Aug 23;72:109651. Epub 2020 Apr 23.

Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, United States. Electronic address:

Src family kinases (SFKs) play a crucial role in the regulation of multiple cellular pathways, including mitochondrial oxidative phosphorylation (OXPHOS). Aberrant activities of one of the most predominant SFKs, c-Src, was identified as a fundamental cause for dysfunctional cell signaling and implicated in cancer development and metastasis, especially in human hepatocellular carcinoma (HCC). Recent work in our laboratory revealed that c-Src is implicated in the regulation of mitochondrial energy metabolism in cancer. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109651DOI Listing

Smac mimetic promotes TNF-α to induce apoptosis of gallbladder carcinoma cells.

Cell Signal 2020 Aug 22;72:109654. Epub 2020 Apr 22.

Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fujian Medical University, Fuzhou, China; Key Laboratory of Ministry of Education for Gastrointestinal Cancer and Key Laboratory of Tumour Microbiology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. Electronic address:

Gallbladder carcinoma has a high degree of malignancy. No effective treatment exists for patients with advanced tumors. The second mitochondria-derived activator of caspases (Smac) is the antagonist of the inhibitors of apoptosis protein. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109654DOI Listing

Fibrin fragment E potentiates TGF-β-induced myofibroblast activation and recruitment.

Cell Signal 2020 Aug 22;72:109661. Epub 2020 Apr 22.

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden; Dept. of Radiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.

Fibrin is an essential constituent of the coagulation cascade, and the formation of hemostatic fibrin clots is central to wound healing. Fibrin clots are over time degraded into fibrin degradation products as the injured tissue is replaced by granulation tissue. Our goal was to study the role of the fibrin degradation product fragment E (FnE) in fibroblast activation and migration. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109661DOI Listing

GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D in a Rab4-dependent mechanism.

Cell Signal 2020 Aug 22;72:109641. Epub 2020 Apr 22.

Département de Médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Canada; Institut de Pharmacologie de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Canada. Electronic address:

Mechanisms controlling the recycling of G protein-coupled receptors (GPCRs) remain largely unclear. We report that GGA3 (Golgi-associated, γ adaptin ear containing, ADP-ribosylation factor-binding protein 3) regulates the recycling and signaling of the PGD receptor DP1 through a new mechanism. An endogenous interaction between DP1 and GGA3 was detected by co-immunoprecipitation in HeLa cells. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109641DOI Listing
August 2020
4.315 Impact Factor

Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ.

Cell Signal 2020 Aug 21;72:109662. Epub 2020 Apr 21.

Division of Oral Biotechnology, Center for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, Germany. Electronic address:

In the context of mechanically induced force transmission, the modification of the actin cytoskeleton through involvement of zyxin is an established concept. However, in cells of the periodontal ligament (PDL), which is physiologically subjected to intermittent mechanical forces, the force-responsive modulation of zyxin and the molecular key players, which orchestrate its cellular regulation, have not yet been elucidated. By employing indirect immunofluorescence and western blotting with different subcellular fractions, we show here in stretch force-exposed human PDL fibroblasts (hPDLFs) that (i) the zyxin protein is modulated, and (ii) its subcellular localization is altered. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109662DOI Listing

Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation.

Cell Signal 2020 Aug 21;72:109653. Epub 2020 Apr 21.

Department of Biology, University of North Carolina Asheville, One University Heights, Asheville, NC 28804, United States of America. Electronic address:

The G12/13 subfamily of heterotrimeric guanine nucleotide binding proteins comprises the α subunits Gα12 and Gα13, which transduce signals for cell growth, cytoskeletal rearrangements, and oncogenic transformation. In an increasing range of cancers, overexpressed Gα12 or Gα13 are implicated in aberrant cell proliferation and/or metastatic invasion. Although Gα12 and Gα13 bind non-redundant sets of effector proteins and participate in unique signalling pathways, the structural features responsible for functional differences between these α subunits are largely unknown. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109653DOI Listing

STAT signaling in polycystic kidney disease.

Cell Signal 2020 Aug 20;72:109639. Epub 2020 Apr 20.

Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106-9625, USA. Electronic address:

The most common form of polycystic kidney disease (PKD) in humans is caused by mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or proposed functions of PC1 is its ability to regulate the activity of transcription factors of the STAT family. Most STAT proteins that have been investigated were found to be aberrantly activated in kidneys in PKD, and some have been shown to be drivers of disease progression. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269822PMC

Between life and death: Epithelial cells in lung pathologies.

Cell Signal 2020 Aug 20;72:109652. Epub 2020 Apr 20.

Institute of Pharmacology and Toxicology, Goethe University, Frankfurt Am Main, Germany.

Recent lineage tracing strategies, single-cell RNA sequencing approaches and high-resolution imaging identified remarkable heterogeneity of lung epithelial cells thus leaving open a question as to their specific functions in lung health and disease. Understanding the molecular mechanisms controlling lung epithelial cell morphogenesis and differentiation as well as communication with other cell types and extracellular matrix provides a basis for improving the outcome for patients with respiratory diseases. Although, the substantial progress has been made towards achieving this goal, we are still far away from being able to train/instruct lung epithelial cells in order to facilitate lung repair and regeneration. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109652DOI Listing

Role of chemokines, innate and adaptive immunity.

Cell Signal 2020 Apr 20;73:109647. Epub 2020 Apr 20.

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Veterans Affairs Medical Center, Birmingham, AL 35233, USA. Electronic address:

Polycystic Kidney Disease (PKD) triggers a robust immune system response including changes in both innate and adaptive immunity. These changes involve immune cells (e.g. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109647DOI Listing

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma.

Cell Signal 2020 Aug 19;72:109638. Epub 2020 Apr 19.

CRUK Beatson Institute, Glasgow, UK; Division of Cellular and Molecular Medicine, School of Medicine, University of Dundee, Dundee, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address:

Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14-15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109638DOI Listing

Aberrant TRPM4 expression in MLL-rearranged acute myeloid leukemia and its blockade induces cell cycle arrest via AKT/GLI1/Cyclin D1 pathway.

Cell Signal 2020 Aug 19;72:109643. Epub 2020 Apr 19.

Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan, China. Electronic address:

Transient Receptor Potential Melastatin Subfamily Member 4 (TRPM4) has been demonstrated to be aberrantly expressed in several cancers but seldom reported in acute leukemia. Based on database mining and validated experiments, our present data show that TRPM4 is selectively overexpressed in AML patients and cell lines with the MLL gene rearrangement. We analyzed the correlation between TRPM4 expression and clinical parameters in a validated cohort of AML patients. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109643DOI Listing
August 2020
4.315 Impact Factor

Molecular pathways involved in injury-repair and ADPKD progression.

Cell Signal 2020 Aug 19;72:109648. Epub 2020 Apr 19.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333, ZC, Leiden, the Netherlands. Electronic address:

The major hallmark of Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the formation of many fluid-filled cysts in the kidneys, which ultimately impairs the normal renal structure and function, leading to end-stage renal disease (ESRD). A large body of evidence suggests that injury-repair mechanisms are part of ADPKD progression. Once cysts have been formed, proliferation and fluid secretion contribute to the cyst size increase, which eventually causes stress on the surrounding tissue resulting in local injury and fibrosis. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109648DOI Listing

Post-translational modifications of the polycystin proteins.

Cell Signal 2020 Aug 19;72:109644. Epub 2020 Apr 19.

Kidney Genetics Group, Academic Nephrology Unit, University of Sheffield Medical School, Sheffield, UK.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and affects up to 12 million people worldwide. Germline mutations in two genes, PKD1 or PKD2, account for almost all patients with ADPKD. The ADPKD proteins, polycystin-1 (PC1) and polycystin-2 (PC2), are regulated by post-translational modifications (PTM), with phosphorylation, glycosylation and proteolytic cleavage being the best described changes. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109644DOI Listing

miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis.

Cell Signal 2020 Aug 19;72:109650. Epub 2020 Apr 19.

Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, PR China. Electronic address:

Epithelial-mesenchymal transition (EMT), a pivotal event during cancer progression such as relapse and metastasis, is positively correlated with the stemness potency of tumor cells. Our previous study showed that miR-296-5p attenuated EMT program of hepatocellular carcinoma cells (HCC) through NRG1/ERBB2/ERBB3 signaling. In the present study, we uncovered that miR-296-5p was able to inhibit the stemness potency of HCC by decreasing the number and size of tumorspheres, downregulating the expression of CSC biomarkers and hampering the ability of tumorigenesis in NOD/SCID mice. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109650DOI Listing

Extracellular matrix, integrins, and focal adhesion signaling in polycystic kidney disease.

Cell Signal 2020 Aug 18;72:109646. Epub 2020 Apr 18.

Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, United States; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, United States; The Jared Grantham Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, United States. Electronic address:

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage, inflammation, and fibrosis, and progressive decline in kidney function. It has long been recognized that interstitial fibrosis is the most important manifestation associated with end-stage renal disease; however, the role of abnormal extracellular matrix (ECM) production on ADPKD pathogenesis is not fully understood. Early evidence showed that cysts in end-stage human ADPKD kidneys had thickened and extensively laminated cellular basement membranes, and abnormal regulation of gene expression of several basement membrane components, including collagens, laminins, and proteoglycans by cyst epithelial cells. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269823PMC

Polycystins as components of large multiprotein complexes of polycystin interactors.

Cell Signal 2020 Aug 17;72:109640. Epub 2020 Apr 17.

Department of Cell Biology, The University of Oklahoma Health Sciences Center, BRC262, 975 NE 10th Street, Oklahoma City, OK 73104, United States of America. Electronic address:

Naturally occurring mutations in two separate genes, PKD1 and PKD2, are responsible for the vast majority of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases affecting 1 in 1000 Americans. The hallmark of ADPKD is the development of epithelial cysts in the kidney, liver, and pancreas. PKD1 encodes a large plasma membrane protein (PKD1, PC1, or Polycystin-1) with a long extracellular domain and has been speculated to function as an atypical G protein coupled receptor. Read More

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http://dx.doi.org/10.1016/j.cellsig.2020.109640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269800PMC