520 results match your criteria Cellular oncology Dordrecht[Journal]


Role of the bone microenvironment in bone metastasis of malignant tumors - therapeutic implications.

Authors:
Xiaoting Ma Jing Yu

Cell Oncol (Dordr) 2020 Jul 4. Epub 2020 Jul 4.

Cancer Center, Beijing Friendship Hospital, Capital Medical University, No.95 Yong An Road, Xi Cheng District, Beijing, 100050, China.

Background: Bone is one of the most common sites for solid tumor metastasis. Bone metastasis of a malignant tumor seriously affects the quality of life and the overall survival of patients. Evidence has suggested that bone provides a favorable microenvironment that enables disseminated tumor cells to home, proliferate and colonize, leading to the formation of metastases. Read More

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http://dx.doi.org/10.1007/s13402-020-00512-wDOI Listing

Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation.

Cell Oncol (Dordr) 2020 Jul 4. Epub 2020 Jul 4.

Liver Disease Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No.528. Zhangheng Road, Pudong New District, Shanghai, People's Republic of China.

Purpose: Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), which has a male predominance, lacks effective therapeutic options. Previously, the cardiac glycoside analogue bufalin has been found to inhibit HBV infection and HCC development. As yet, however, its molecular role in HBV-associated HCC has remained obscure. Read More

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http://dx.doi.org/10.1007/s13402-020-00546-0DOI Listing

Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules.

Cell Oncol (Dordr) 2020 Jun 23. Epub 2020 Jun 23.

Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665# Kongjiang Road, Shanghai, 200090, China.

Background: Tumor cell-derived exosomes (TEXs) have been widely used to induce antitumor immune responses in animal models and clinical trials. Similarly, leukemia cell-derived exosomes (LEXs) can induce antileukemia immune responses in animal models. However, the antileukemia immunity induced by LEXs is less effective, which may be due to an inadequate costimulatory capacity. Read More

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http://dx.doi.org/10.1007/s13402-020-00535-3DOI Listing

BAG3 interacts with p53 in endometrial carcinoma.

Cell Oncol (Dordr) 2020 Jun 23. Epub 2020 Jun 23.

Department of Medicine, Surgery and Odontology "Scuola Medica Salernitana", University of Salerno, 84081, Baronissi, SA, Italy.

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http://dx.doi.org/10.1007/s13402-020-00543-3DOI Listing

LINC01419 promotes cell proliferation and metastasis in hepatocellular carcinoma by enhancing NDRG1 promoter activity.

Cell Oncol (Dordr) 2020 Jun 15. Epub 2020 Jun 15.

Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Yi Xue Yuan Road, Chongqing, 400016, China.

Purpose: Emerging evidence indicates that dysfunction of long non-coding RNAs (lncRNAs) plays an essential role in the initiation and progression of hepatocellular carcinoma (HCC). In this study we investigated the potential roles and molecular mechanisms involving LINC01419 in HCC.

Methods: The expression of LINC01419 in 40 pairs of HCC/normal tissues and 6 HCC cell lines was detected by qRT-PCR. Read More

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http://dx.doi.org/10.1007/s13402-020-00540-6DOI Listing

EBV-miR-BART10-3p and EBV-miR-BART22 promote metastasis of EBV-associated gastric carcinoma by activating the canonical Wnt signaling pathway.

Cell Oncol (Dordr) 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Rd, Guangzhou, 510630, China.

Purpose: Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) constitutes the largest subpopulation in EBV-associated tumors worldwide. To date, 44 mature EBV-encoded microRNAs (EBV miRNAs) have been identified, but their roles in EBVaGC development are still poorly understood. In this study, we aimed to investigate the roles and targets of ebv-miR-BART10-3p (BART10-3p) and ebv-miR-BART22 (BART22) in EBVaGC. Read More

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http://dx.doi.org/10.1007/s13402-020-00538-0DOI Listing

DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications.

Authors:
Kah Keng Wong

Cell Oncol (Dordr) 2020 Jun 5. Epub 2020 Jun 5.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the leading causes of cancer-related deaths in both genders. Epigenetic alterations may lead to the suppression of tumor suppressor genes, and DNA methylation is a predominant epigenetic modification. Read More

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http://dx.doi.org/10.1007/s13402-020-00526-4DOI Listing

Non-coding RNAs underlying chemoresistance in gastric cancer.

Cell Oncol (Dordr) 2020 Jun 3. Epub 2020 Jun 3.

Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran.

Background: Gastric cancer (GC) is a major health issue in the Western world. Current clinical imperatives for this disease include the identification of more effective biomarkers to detect GC at early stages and enhance the prevention and treatment of metastatic and chemoresistant GC. The advent of non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long-non coding RNAs (lncRNAs), has led to a better understanding of the mechanisms by which GC cells acquire features of therapy resistance. Read More

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http://dx.doi.org/10.1007/s13402-020-00528-2DOI Listing
June 2020
3.032 Impact Factor

Selective capture of plasma cell-free tumor DNA on magnetic beads: a sensitive and versatile tool for liquid biopsy.

Cell Oncol (Dordr) 2020 Jun 3. Epub 2020 Jun 3.

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Recently, 'solid tumor biopsies' have been challenged by the emergence of 'liquid biopsies', which are aimed at the isolation and detection of circulating cell-free tumor DNA (ctDNA) in body fluids. Here, we developed and optimized a method for selective capture of ctDNA on magnetic beads (SCC-MAG) for mutation detection in plasma of patients with colorectal cancer (CRC).

Methods: Blood and tissue samples from 28 CRC patients were included for the detection of KRAS mutations. Read More

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http://dx.doi.org/10.1007/s13402-020-00536-2DOI Listing

Noncoding RNAs in oral premalignant disorders and oral squamous cell carcinoma.

Cell Oncol (Dordr) 2020 Jun 3. Epub 2020 Jun 3.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Background: Oral squamous cell carcinoma (OSCC) has the highest mortality rate among all head and neck cancers and a relatively low five-year survival rate. Generally, the development of an oral mucosal malignancy represents a multistep process beginning with normal oral mucosa epithelium and culminating in OSCC after transitioning through intermediary oral premalignant disorders (OPMDs), during which dysplasia is often observed. Noncoding RNAs (ncRNAs) are RNAs that are not translated into proteins, but still can participate in regulating neoplastic cell behavior. Read More

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http://dx.doi.org/10.1007/s13402-020-00521-9DOI Listing

HIF1A expression correlates with increased tumor immune and stromal signatures and aggressive phenotypes in human cancers.

Cell Oncol (Dordr) 2020 Jun 1. Epub 2020 Jun 1.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

Background: Although many studies have revealed essential roles of HIF1A (hypoxia inducible factor 1 subunit alpha) in regulating various pathways associated with cancer development, a systematic investigation of associations of HIF1A expression with tumor immunity, the tumor microenvironment and other tumor phenotypes in pan-cancer is lacking.

Methods: Using cancer genomics datasets of 10 cancer cohorts from the Cancer Genome Atlas (TCGA) program, we investigated associations of HIF1A expression with tumor immune and stromal signatures, and various tumor phenotypes, including cell proliferation, stemness, epithelial-mesenchymal transition (EMT), tumor purity, oncogenic signaling, and clinical outcomes.

Results: HIF1A upregulation was found to be associated with increased immune and stromal signatures, aggressive phenotypes, and worse survival rates in various cancers. Read More

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http://dx.doi.org/10.1007/s13402-020-00534-4DOI Listing

Sp1-mediated up-regulation of lnc00152 promotes invasion and metastasis of retinoblastoma cells via the miR-30d/SOX9/ZEB2 pathway.

Cell Oncol (Dordr) 2020 Jun 1. Epub 2020 Jun 1.

Department of Obstetrics and Gynaecology, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, 518020, Shenzhen, People's Republic of China.

Purpose: Previously, we found that long non-coding RNA (lncRNA) MEG3 may act as a tumour suppressor in retinoblastoma. Overall, however, little is known about the role of lncRNAs in retinoblastoma. Here, we aimed to determine the expression and clinical significance of lnc00152 in retinoblastoma. Read More

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http://dx.doi.org/10.1007/s13402-020-00522-8DOI Listing

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance.

Cell Oncol (Dordr) 2020 Jun 2. Epub 2020 Jun 2.

Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, ul. Chalubinskiego 6a, 50-368, Wroclaw, Poland.

Background: Tumor initiation and subsequent progression are usually long-term processes, spread over time and conditioned by diverse aspects. Many cancers develop on the basis of chronic inflammation; however, despite dozens of years of research, little is known about the factors triggering neoplastic transformation under these conditions. Molecular characterization of both pathogenetic states, i. Read More

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http://dx.doi.org/10.1007/s13402-020-00519-3DOI Listing

Ascofuranone suppresses invasion and F-actin cytoskeleton organization in cancer cells by inhibiting the mTOR complex 1 signaling pathway.

Cell Oncol (Dordr) 2020 Jun 2. Epub 2020 Jun 2.

Research Institute of Biomedical Engineering, Department of Medicine, Catholic University of Daegu School of Medicine, 42472, Deagu, Korea.

Purpose: Ascofuranone is an antiviral antibiotic that is known to exert multiple anti-tumor effects, including cell cycle arrest, inhibition of mitochondrial respiration, and inhibition of angiogenesis. In this study, we investigated the molecular mechanisms underlying the anti-metastatic effects of ascofuranone in insulin-like growth factor-I (IGF-1)-responsive cancer cells.

Methods: The inhibitory effect of ascofuranone on cancer cell migration and invasion was assessed using scratch wound healing and Matrigel invasion assays, respectively. Read More

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http://dx.doi.org/10.1007/s13402-020-00520-wDOI Listing

Functional and metabolic targeting of natural killer cells to solid tumors.

Cell Oncol (Dordr) 2020 Jun 2. Epub 2020 Jun 2.

Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.

Background: The unique ability of NK cells to target cancer cells without antigen specificity makes them an attractive prospect for immunotherapy of solid tumors. However, the complexity of the tumor microenvironment (TME), particularly its heterogeneity and associated immunosuppressive properties, enables solid tumor cells to escape NK cell immune-surveillance by impairing their infiltration and cytotoxic functions. As a result, NK cells that have been able to infiltrate solid tumors are dysfunctional, exhausted and metabolically and functionally impaired. Read More

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http://dx.doi.org/10.1007/s13402-020-00523-7DOI Listing

Association of Jagged1 expression with malignancy and prognosis in human pancreatic cancer.

Cell Oncol (Dordr) 2020 Jun 1. Epub 2020 Jun 1.

Department of Applied Life Science, SARI, Jeju National University, 102 Jejudaehak-ro, Jeju-si, Jeju-do, 63243, Republic of Korea.

Purpose: Pancreatic cancer is one of the most aggressive cancers. Preclinical and clinical data indicate that Notch 1 ligand jagged1 (JAG1) plays a pro-oncogenic role in several malignant cancers. As yet, however, the role of JAG1 in pancreatic cancer is poorly understood. Read More

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http://dx.doi.org/10.1007/s13402-020-00527-3DOI Listing

Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and update.

Cell Oncol (Dordr) 2020 May 30. Epub 2020 May 30.

Department of Clinical Pharmacology and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, People's Republic of China.

Background: Colorectal cancer (CRC) is a disease with high morbidity and mortality rates. 5-fluorouracil (5-FU) is the first-line recommended drug for chemotherapy in patients with CRC, and it has a good effect on a variety of other solid tumors as well. Unfortunately, however, due to the emergence of drug resistance the effectiveness of treatment may be greatly reduced. Read More

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http://dx.doi.org/10.1007/s13402-020-00529-1DOI Listing
May 2020
3.032 Impact Factor

A lectin-based glycomic approach identifies FUT8 as a driver of radioresistance in oesophageal squamous cell carcinoma.

Cell Oncol (Dordr) 2020 May 30. Epub 2020 May 30.

Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People's Republic of China.

Purpose: Radio-resistance is recognized as a main factor in the failure of radiotherapy in oesophageal squamous cell carcinoma (ESCC). Aberrant cell surface glycosylation has been reported to correlate with radio-resistance in different kinds of tumours. However, glycomic alterations and the corresponding enzymes associated with ESCC radio-resistance have not yet been defined. Read More

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http://dx.doi.org/10.1007/s13402-020-00517-5DOI Listing

CD105 is a prognostic marker and valid endothelial target for microbubble platforms in cholangiocarcinoma.

Cell Oncol (Dordr) 2020 May 28. Epub 2020 May 28.

Leeds Institute of Medical Research, St James's University Hospital, Leeds, LS9 7TF, UK.

Purpose: The current treatment outcomes in cholangiocarcinoma are poor with cure afforded only by surgical extirpation. The efficacy of targeting the tumoural endothelial marker CD105 in cholangiocarcinoma, as a basis for potential microbubble-based treatment, is unknown and was explored here.

Methods: Tissue expression of CD105 was quantified using immunohistochemistry in 54 perihilar cholangiocarcinoma samples from patients who underwent resection in a single centre over a ten-year period, and analysed against clinicopathological data. Read More

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http://dx.doi.org/10.1007/s13402-020-00530-8DOI Listing
May 2020
3.032 Impact Factor

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers.

Cell Oncol (Dordr) 2020 May 28. Epub 2020 May 28.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: In cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT. Yet, most cancers show only modest levels of TERT gene expression, even in the context of activating hotspot promoter mutations (C228T and C250T). The role of epigenetic mechanisms, including DNA methylation, in regulating TERT gene expression in cancer cells is as yet not fully understood. Read More

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http://dx.doi.org/10.1007/s13402-020-00531-7DOI Listing
May 2020
3.032 Impact Factor

Systematic profiling of immune signatures identifies prognostic predictors in lung adenocarcinoma.

Cell Oncol (Dordr) 2020 May 28. Epub 2020 May 28.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Purpose: Lung adenocarcinoma (LUAD) is the predominant subtype of lung cancer, with increasing evidence showing clinical benefits of immunotherapy. However, a lack of integrated profiles of complex LUAD immune microenvironments hampers the application of immunotherapy, resulting in limited eligible patient populations as well as drug resistance problems. Here, we aimed to systematically profile the immune signatures of LUADs and to assess the role of the immune microenvironment in patient outcome. Read More

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http://dx.doi.org/10.1007/s13402-020-00515-7DOI Listing
May 2020
3.032 Impact Factor

LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation.

Cell Oncol (Dordr) 2020 May 24. Epub 2020 May 24.

Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

Background: Emerging evidence indicates a regulatory role of long non-coding RNAs (lncRNAs) in the development of gastric cancer (GC), but the mechanisms underlying their function have remained largely unknown. Recent microarray-based expression profiling has led to the identification of a novel differentially expressed lncRNA, LINC00858, in GC. Subsequently, LINC00858 was found to be highly expressed in GC tissues and cells. Read More

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http://dx.doi.org/10.1007/s13402-020-00518-4DOI Listing

Pure high-grade papillary urothelial bladder cancer: a luminal-like subgroup with potential for targeted therapy.

Cell Oncol (Dordr) 2020 May 22. Epub 2020 May 22.

Institute of Pathology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

Purpose: Non-invasive high-grade (HG) bladder cancer is a heterogeneous disease that is characterized insufficiently. First-line Bacillus Calmette-Guérin instillation fails in a substantial amount of cases and alternative bladder-preserving treatments are limited, underlining the need to promote a further molecular understanding of non-invasive HG lesions. Here, we characterized pure HG papillary urothelial bladder cancer (pure pTa HG), a potential subgroup of non-invasive HG bladder carcinomas, with regard to molecular subtype affiliation and potential for targeted therapy. Read More

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http://dx.doi.org/10.1007/s13402-020-00524-6DOI Listing

Downregulation of beta-catenin in chemo-tolerant TNBC through changes in receptor and antagonist profiles of the WNT pathway: Clinical and prognostic implications.

Cell Oncol (Dordr) 2020 May 19. Epub 2020 May 19.

Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata, West Bengal, 700026, India.

Purpose: In approximately 30% of triple-negative breast cancer (TNBC) patients a complete pathological response is achieved. However, after neo-adjuvant chemotherapy treatment (NACT) residual tumour cells can be intrinsically resistant to chemotherapy. In this study, associations of the WNT/beta-catenin pathway with chemo-tolerance of NACT treated TNBC patients were compared to that of pre-treatment TNBC patients. Read More

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http://dx.doi.org/10.1007/s13402-020-00525-5DOI Listing

Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles.

Cell Oncol (Dordr) 2020 May 16. Epub 2020 May 16.

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Ovarian cancer is the most lethal gynecologic cancer and the fifth leading cause of cancer-related mortality in women worldwide. Despite various attempts to improve the diagnosis and therapy of ovarian cancer patients, the survival rate for these patients is still dismal, mainly because most of them are diagnosed at a late stage. Up to 90% of ovarian cancers arise from neoplastic transformation of ovarian surface epithelial cells, and are usually referred to as epithelial ovarian cancer (EOC). Read More

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http://dx.doi.org/10.1007/s13402-020-00513-9DOI Listing

Zebularine-induced myeloma cell death is accompanied by decreased c-Myc expression.

Cell Oncol (Dordr) 2020 May 11. Epub 2020 May 11.

Hematology Department, University Hospital of Salamanca IBSAL, Salamanca, Spain.

Purpose: Epigenetic therapies have proven to be clinically effective in several hematological malignancies. Here, we aimed to evaluate the effect of a second-generation DNA demethylation agent, zebularine, on multiple myeloma (MM).

Methods: Western blot, ELISA, qRT-PCR, proliferation assays and cell transfection were used to investigate the mechanism of action of zebularine in MM. Read More

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http://dx.doi.org/10.1007/s13402-020-00516-6DOI Listing

The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary.

Cell Oncol (Dordr) 2020 May 8. Epub 2020 May 8.

Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), 38, Sardar Patel Road, Guindy, Chennai, Tamil Nadu, 600036, India.

Purpose: Signaling by cancer stem cells (CSCs) is known to occur at least in part through conserved developmental pathways. Here, the role of one of these pathways, i.e. Read More

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http://dx.doi.org/10.1007/s13402-020-00504-wDOI Listing
May 2020
3.032 Impact Factor

The PI3K/mTOR dual inhibitor GSK458 potently impedes ovarian cancer tumorigenesis and metastasis.

Cell Oncol (Dordr) 2020 May 8. Epub 2020 May 8.

Department of Obstetrics and Gynecology, Shanghai Fengxian District Central Hospital, Southern Medical University, 201499, Shanghai, China.

Purpose: The PI3K/AKT/mTOR pathway is one of the most highly activated cellular signaling pathways in advanced ovarian cancer. Although several PI3K/AKT/mTOR inhibitors have been developed to treat various types of cancer, the antitumor efficacy of many of these compounds against ovarian cancer has remained unclear.

Methods: Here, we tested and compared a panel of 16 PI3K/AKT/mTOR inhibitors (XL765, Miltefosine, Rapamycin, CCI-779, RAD001, FK506, XL147, GSK2110183, IPI-145, GSK2141795, BYL719, GSK458, CAL-101, XL765 analogue SAR245409, Triciribine, and GDC0941) that have entered clinical trials for antitumor activity against ovarian cancer, as well as the front line drug, paclitaxel. Read More

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http://dx.doi.org/10.1007/s13402-020-00514-8DOI Listing

WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/β-catenin pathway.

Cell Oncol (Dordr) 2020 Jun 16;43(3):489-503. Epub 2020 Apr 16.

Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

Purpose: Persistent infection with high-risk human papillomavirus (HR-HPV) is thought to play a prominent role in the initiation and progression of almost all cases of cervical cancer. Previously, we and others found that microRNA 34a (miR-34a) may be regulated by HR-HPV E6 to contribute to the development of cervical cancer. Here, we aimed to identify the oncogenic potential and clinical significance of a known miR-34a target, WNT1, in cervical squamous cell carcinoma (SCC) development and to investigate the associated mechanisms underlying cervical SCC cell proliferation and invasion. Read More

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http://dx.doi.org/10.1007/s13402-020-00506-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214512PMC

CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145.

Cell Oncol (Dordr) 2020 Jun 15;43(3):477-488. Epub 2020 Apr 15.

Department of Chemoradiation Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality world-wide. Recently, a number of circular RNAs (circRNAs) has been found to be differentially expressed in human NSCLCs, correlating with clinico-pathological features. As yet, the expression and potential role of circRNA BIRC6 (circBIRC6) in NSCLC have not been studied. Read More

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http://dx.doi.org/10.1007/s13402-020-00503-xDOI Listing

Effect of EphA2 knockdown on melanoma metastasis depends on intrinsic ephrinA1 level.

Cell Oncol (Dordr) 2020 Apr 14. Epub 2020 Apr 14.

Department of Pathology, Tianjin Medical University, 300070, Tianjin, China.

Purpose: Upregulation of receptor tyrosine kinase EphA2 has been found to be associated with a poor prognosis in many types of cancer and is considered an attractive therapeutic target. As yet, few efforts have been focused on its tumor suppressive activity triggered by its ligand, ephrinA1. Here, we aimed to determine the potential of ephrinA1 as an important player in melanoma metastasis. Read More

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http://dx.doi.org/10.1007/s13402-020-00511-xDOI Listing

Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients.

Cell Oncol (Dordr) 2020 Jun 7;43(3):505-511. Epub 2020 Apr 7.

Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Purpose: Progress in radiation therapy of head and neck squamous cell carcinomas (HNSCCs) is logically linked to the development of molecular predictors that would help to enhance individually tailored treatment. MicroRNA (miRNA) expression profiles in tumors have repeatedly been tested to optimize the molecular diagnostics of HNSCC. In addition to tumor tissues, miRNAs are stably present in body fluids, including saliva, and can thus be collected non-invasively. Read More

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http://dx.doi.org/10.1007/s13402-020-00507-7DOI Listing
June 2020
3.032 Impact Factor

Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations.

Cell Oncol (Dordr) 2020 Apr 2. Epub 2020 Apr 2.

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192, Japan.

Background: Sal-like protein 4 (SALL4), an embryonic stem cell factor, has been reported to play an essential role in embryogenesis and oncogenesis. As yet, however, the expression and role of this transcription factor in head and neck squamous cell carcinoma (HNSCC) has not been established.

Methods: We assessed SALL4 mRNA expression in a well-characterised dataset of 230 HNSCC samples (test cohort 110 cases and validation cohort 120 cases). Read More

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http://dx.doi.org/10.1007/s13402-020-00509-5DOI Listing

IL-17A and IL-17F orchestrate macrophages to promote lung cancer.

Cell Oncol (Dordr) 2020 Mar 29. Epub 2020 Mar 29.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.

Purpose: Previously, inflammation has been found to be associated with the development of lung cancer. Despite their well-characterized pro-inflammatory functions, the putative roles of interleukin-17 (IL-17) cytokine family members in tumorigenesis have remained controversial. While IL-17A exhibits both pro- and anti-tumor effects, IL-17F has been suggested to serve as a candidate for cancer therapy. Read More

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http://dx.doi.org/10.1007/s13402-020-00510-yDOI Listing

PFKP is highly expressed in lung cancer and regulates glucose metabolism.

Cell Oncol (Dordr) 2020 Mar 26. Epub 2020 Mar 26.

Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province, Whenzhou Medical University, Linhai, 317000, China.

Purpose: Although it has been reported that up-regulation of phosphofructokinase (PFK) expression is a major feature of malignant tumors, the role of platelet type PFK (PFKP) in tumor initiation and progression is as yet poorly understood. The objective of this study was to evaluate PFKP expression in lung cancer and its effect on glycolysis, and to explore correlations between PFKP expression levels and clinical lung cancer patient features.

Methods: PFKP mRNA expression levels in cancer tissues and adjacent normal tissues were compared using The Cancer Genome Atlas (TCGA) database. Read More

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http://dx.doi.org/10.1007/s13402-020-00508-6DOI Listing

Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors.

Cell Oncol (Dordr) 2020 Jun 26;43(3):367-376. Epub 2020 Mar 26.

Toxicology and Biomedicine Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Background: Insulinoma-associated protein 1 (INSM1), a transcriptional regulator with a zinc-finger DNA-binding domain, has been validated as a cytoplasmic marker for neuroendocrine differentiation of tumor cells. Next to its abundant expression in the fetal pancreas, it is expressed in brain tumors, pheochromocytomas, medullary thyroid carcinomas, insulinomas and pituitary and small-cell lung carcinomas. INSM1 is not expressed in normal adult tissues and/or most non-neuroendocrine tumors. Read More

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http://dx.doi.org/10.1007/s13402-020-00505-9DOI Listing

The role of ErbB4 in cancer.

Cell Oncol (Dordr) 2020 Jun 26;43(3):335-352. Epub 2020 Mar 26.

Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

Background: The epidermal growth factor receptor family consists of four members, ErbB1 (epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found to play important roles in tumor development. ErbB4 appears to be unique among these receptors, because it is the only member with growth inhibiting properties. ErbB4 plays well-defined roles in normal tissue development, in particular the heart, the nervous system, and the mammary gland system. Read More

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http://dx.doi.org/10.1007/s13402-020-00499-4DOI Listing

Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma.

Cell Oncol (Dordr) 2020 Jun 23;43(3):461-475. Epub 2020 Mar 23.

Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.

Purpose: The iron-chelating agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) has been found to inhibit cell growth and to induce apoptosis in several human cancers. However, its effects and mechanism of action in glioma are unknown.

Methods: Human glioma cell line LN229 and patient-derived glioma stem cells GSC-42 were applied for both in vitro and in vivo xenograft nude mouse experiments. Read More

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http://dx.doi.org/10.1007/s13402-020-00502-yDOI Listing

CXCL-10: a new candidate for melanoma therapy?

Cell Oncol (Dordr) 2020 Jun 23;43(3):353-365. Epub 2020 Mar 23.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R., Iran.

Background: Melanoma is a malignancy that stems from melanocytes and is defined as the most dangerous skin malignancy in terms of metastasis and mortality rates. CXC motif chemokine 10 (CXCL10), also known as interferon gamma-induced protein-10 (IP-10), is a small cytokine-like protein secreted by a wide variety of cell types. CXCL10 is a ligand of the CXC chemokine receptor-3 (CXCR3) and is predominantly expressed by T helper cells (Th cells), cytotoxic T lymphocytes (CTLs), dendritic cells, macrophages, natural killer cells (NKs), as well as some epithelial and cancer cells. Read More

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http://dx.doi.org/10.1007/s13402-020-00501-zDOI Listing

Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.

Cell Oncol (Dordr) 2020 Jun 19;43(3):445-460. Epub 2020 Mar 19.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, Bloco 12 inferior, sala 1200, São Paulo, SP, 05508-000, Brazil.

Purpose: Oncogenic KRAS mutations are found in over 90% of pancreatic ductal adenocarcinomas (PDACs). As yet, however, no effective therapies are available for KRAS-induced malignancies. Therefore, research aimed at the identification of KRAS targets with therapeutic potential is warranted. Read More

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http://dx.doi.org/10.1007/s13402-020-00498-5DOI Listing

Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer.

Cell Oncol (Dordr) 2020 Jun 12;43(3):431-444. Epub 2020 Mar 12.

Translational Oncology Laboratory, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla-La Mancha: Campus de Albacete, C/ Almansa 14, 02008, Albacete, Spain.

Purpose: Triple negative breast cancers (TNBCs) are enriched in cells bearing stem-like features, i.e., cancer stem cells (CSCs), which underlie cancer progression. Read More

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http://dx.doi.org/10.1007/s13402-020-00497-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214516PMC

Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer.

Cell Oncol (Dordr) 2020 Jun 12;43(3):409-420. Epub 2020 Mar 12.

Department of Gastroenterology and Hepatology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China.

Purpose: DCBLD2 expression dysregulation has been reported in several types of human cancer. As yet, however, the role of DCBLD2 in colorectal cancer (CRC) is not known.

Methods: CRC tissues were obtained from patients undergoing surgery from February 2009 to May 2014 (n = 90). Read More

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http://dx.doi.org/10.1007/s13402-020-00495-8DOI Listing

Prevalence of CD8 cytotoxic lymphocytes in human neoplasms.

Cell Oncol (Dordr) 2020 Jun 5;43(3):421-430. Epub 2020 Mar 5.

Institute of Pathology, Martinistraße 52, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.

Purpose: Immune checkpoint inhibitors have recently been approved by the US FDA as first and/or second line therapy in a subset of cancer types. Recent evidence suggests that the quantity of tumor infiltrating lymphocytes (TILs) influences the likelihood of response to immune checkpoint inhibitors. Here, we set out to assess the density of CD8 lymphocytes in a wide range of different cancer types and subtypes. Read More

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http://dx.doi.org/10.1007/s13402-020-00496-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214387PMC

Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation.

Cell Oncol (Dordr) 2020 Jun 4;43(3):377-394. Epub 2020 Mar 4.

Department of Thoracic Surgery, Shanxi Provincial People's Hospital, No. 29, Shuangta Temple Street, Taiyuan, 030012, Shanxi Province, People's Republic of China.

Background: Long non-coding RNAs (lncRNAs) are transcribed pervasively in the genome and act to regulate chromatin remodeling and gene expression. Dysregulated lncRNA expression has been reported in many cancers, but the role of lncRNAs in esophageal cancer (EC) has so far remained poorly understood. In this study, we aimed to understand the effect of lncRNA LINC01234 on EC development through competitively binding to microRNA-193a-5p (miR-193a-5p). Read More

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http://dx.doi.org/10.1007/s13402-019-00493-5DOI Listing
June 2020
3.032 Impact Factor

The exosomal integrin α5β1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration.

Cell Oncol (Dordr) 2020 Apr 21;43(2):263-277. Epub 2020 Feb 21.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.

Purpose: Epithelial ovarian cancer (EOC) is one of the most malignant cancers in the gynecologic system. Many patients are diagnosed at an advanced stage with disseminated intra-peritoneal metastases. EOC spreads via both direct extension and trans-coelomic spread. Read More

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http://dx.doi.org/10.1007/s13402-019-00486-4DOI Listing

FAM83D promotes epithelial-mesenchymal transition, invasion and cisplatin resistance through regulating the AKT/mTOR pathway in non-small-cell lung cancer.

Cell Oncol (Dordr) 2020 Jun 31;43(3):395-407. Epub 2020 Jan 31.

Key Laboratory Experimental, Teratology of the Ministry of Education, Department of Biochemistry and Molecular Biology, Shandong University School of Basic Medical Sciences, 44 Wenhua Xi Road, Jinan, 250012, Shandong, China.

Purpose: FAM83D has been proposed to act as an oncoprotein in several types of human cancer. Its role and mode of action in human non-small cell lung cancer (NSCLC) metastasis and its impact on chemotherapy are as yet, however, poorly understood.

Methods: FAM83D expression was measured in NSCLC cells and normal lung epithelial cells, as well as in primary NSCLC tissues and corresponding adjacent non-cancerous tissues, using qRT-PCR, Western blotting and immunohistochemistry. Read More

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http://dx.doi.org/10.1007/s13402-020-00494-9DOI Listing
June 2020
3.032 Impact Factor

AR pathway activity correlates with AR expression in a HER2-dependent manner and serves as a better prognostic factor in breast cancer.

Authors:
Dingxie Liu

Cell Oncol (Dordr) 2020 Apr 13;43(2):321-333. Epub 2020 Jan 13.

Bluewater Biotech LLC, PO Box 1010, New Providence, NJ, 07974, USA.

Background: Androgen receptor (AR) antagonists are currently tested in multiple clinical trials for different breast cancer (BC) subtypes, which emphasizes the need for clarifying the role of AR in this type of cancer. Previous studies showed that AR expression was associated with a favorable prognosis in ER-positive BC. However, the true biological effect of AR signaling in BC is not clear. Read More

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http://dx.doi.org/10.1007/s13402-019-00492-6DOI Listing

The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches.

Cell Oncol (Dordr) 2020 Feb 3;43(1):1-18. Epub 2020 Jan 3.

Department of Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.

Background: Breast cancer is the most prevalent cancer among women worldwide and the fifth cause of death among all cancer patients. Breast cancer development is driven by genetic and epigenetic alterations, with the tumor microenvironment (TME) playing an essential role in disease progression and evolution through mechanisms like inflammation promotion. TNF-α is one of the essential pro-inflammatory cytokines found in the TME of breast cancer patients, being secreted both by stromal cells, mainly by tumor-associated macrophages, and by the cancer cells themselves. Read More

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http://dx.doi.org/10.1007/s13402-019-00489-1DOI Listing
February 2020

Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4α and WNK2 regulation.

Cell Oncol (Dordr) 2020 Apr 28;43(2):297-310. Epub 2019 Dec 28.

VIP Medicine, The First Affiliated Hospital of Xinjiang Medical University, No. 137, Liyushan South Road, Urumqi, 830054, Xinjiang Uygur Autonomous Region, People's Republic of China.

Background: Long non-coding RNAs (lncRNAs) are known to be frequently dysregulated in many types of human cancer. As yet, however, their roles in colon carcinogenesis have not been fully elucidated. In the current study, we assessed whether lncRNA LINC00858 may be involved in the progression of colon cancer and, in addition, investigated its downstream targets. Read More

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http://dx.doi.org/10.1007/s13402-019-00490-8DOI Listing
April 2020
3.032 Impact Factor