Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs.
- Whitney M Cleghorn,
- Nada Bulus,
- Seunghyi Kook,
- Vsevolod V Gurevich,
- Roy Zent,
- Eugenia V Gurevich
Cell Signal 2017 Nov 11;42:259-269. Epub 2017 Nov 11.
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, United States. Electronic address:
Arrestins recruit a variety of signaling proteins to active phosphorylated G protein-coupled receptors in the plasma membrane and to the cytoskeleton. Loss of arrestins leads to decreased cell migration, altered cell shape, and an increase in focal adhesions. Small GTPases of the Rho family are molecular switches that regulate actin cytoskeleton and affect a variety of dynamic cellular functions including cell migration and cell morphology. Read More