632 results match your criteria Cellular Polymers[Journal]


Nile Red-Poly(Methyl Methacrylate)/Silica Nanocomposite Particles Increase the Sensitivity of Cervical Cancer Cells to Tamoxifen.

Polymers (Basel) 2020 Jul 8;12(7). Epub 2020 Jul 8.

France Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, F-69622 Lyon, France.

Tamoxifen (TAM) is a hormonal drug and is mainly used as an anti-estrogen in breast cancer patients. TAM binds to estrogen receptors (ERs), resulting in inhibition of estrogen signaling pathways and thus, a downregulation of cell proliferation. Cancer cells with negative or low ER expression will not uptake TAM and will show low response. Read More

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http://dx.doi.org/10.3390/polym12071516DOI Listing

Development of a Gene Delivery System of Oligonucleotides for Fibroses by Targeting Cell-Surface Vimentin-Expressing Cells with N-Acetylglucosamine-Bearing Polymer-Conjugated Polyethyleneimine.

Polymers (Basel) 2020 Jul 7;12(7). Epub 2020 Jul 7.

Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan.

Targeting myofibroblasts and activated stellate cells in lesion sites of fibrotic tissues is an important approach to treat fibroses. Herein, we focused on targeting the cytoskeletal proteins vimentin, which are reportedly highly expressed on the surface of these cells and have N-acetylglucosamine (GlcNAc)-binding activity. A GlcNAc-bearing polymer synthesized via radical polymerization with a reversible addition-fragmentation chain transfer reagent has been previously found to interact with cell-surface vimentin-expressing cells. Read More

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http://dx.doi.org/10.3390/polym12071508DOI Listing

The Photoinitiator Lithium Phenyl (2,4,6-Trimethylbenzoyl) Phosphinate with Exposure to 405 nm Light Is Cytotoxic to Mammalian Cells but Not Mutagenic in Bacterial Reverse Mutation Assays.

Polymers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Joint UNC/NCSU Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, USA.

Lithium phenyl (2,4,6-trimethylbenzoyl) phosphinate (LAP) is a free radical photo-initiator used to initiate free radical chain polymerization upon light exposure, and is combined with gelatin methacryloyl (GelMA) to produce a photopolymer used in bioprinting. The free radicals produced under bioprinting conditions are potentially cytotoxic and mutagenic. Since these photo-generated free radicals are highly-reactive but short-lived, toxicity assessments should be conducted with light exposure. Read More

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http://dx.doi.org/10.3390/polym12071489DOI Listing

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers.

Polymers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Department of Carpet, Faculty of Arts, University of Birjand, Birjand 9717434765, Iran.

Mats of polyvinyl alcohol (PVA) core-shell nanofibers were produced using coaxial electrospinning in the presence of a thiosemicarbazone (TSC) 4-(S)-1-phenylethyl)-2-(pyridin-2-yl-ethylidene)hydrazine-1-carbothioamide (HapyTSCmB). Monolithic fibers with 0% or 5% TSC and core-shell fibers with 10% TSC in the spinning solution were studied to compare stability and release rates. SEM showed the formation of uniform, bead-free, cylindrical, and smooth fibers. Read More

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http://dx.doi.org/10.3390/polym12071488DOI Listing

A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds.

Polymers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK.

Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity contributing to the development of more serious conditions such as osteoarthritis. Recent advances in bioprinting have prompted the development of alternative tissue engineering therapies for the generation of AC. Read More

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http://dx.doi.org/10.3390/polym12071478DOI Listing

Association of Hydrophobic Carboxyl-Terminal Dendrimers with Lymph Node-Resident Lymphocytes.

Polymers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.

Delivery systems to lymph node-resident T cells around tumor tissues are essential for cancer immunotherapy, in order to boost the immune responses. We previously reported that anionic dendrimers, such as carboxyl-, sulfonyl-, and phosphate-terminal dendrimers, were efficiently accumulated in lymph nodes via the intradermal injection. Depending on the terminal structure, their cell association properties were different, and the carboxyl-terminal dendrimers did not associate with any immune cells majorly. Read More

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http://dx.doi.org/10.3390/polym12071474DOI Listing

Mucoadhesive Polysaccharide-Based Artificial Tears to Relieve Symptoms and Inflammation in Rabbit with Dry Eyes Syndrome.

Polymers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Graduate Institute of Biomedical Engineering, National Taiwan University, No.49, Fanglan Road, Daan District, Taipei 10051, Taiwan.

Dry eye syndrome (DES) is a multifactorial disorder of the ocular surface affecting many people all over the world. However, there have been many therapeutic advancements for the treatment of DES, substantial long-term treatment remains a challenge. Natural plant-based polysaccharides have gained much importance in the field of tissue engineering for their excellent biocompatibility and unique physical properties. Read More

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http://dx.doi.org/10.3390/polym12071465DOI Listing

Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity.

Polymers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei 10617, Taiwan.

Vascular endothelial growth factor (VEGF) is one of the most crucial growth factors and an assistant for the adjustment of bone regeneration. In this study, a 3D scaffold is fabricated using the method of fused deposition modeling. Such a fabricated method allows us to fabricate scaffolds with consistent pore sizes, which could promote cellular ingrowth into scaffolds. Read More

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http://dx.doi.org/10.3390/polym12071455DOI Listing

Altered Surface Hydrophilicity on Copolymer Scaffolds Stimulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells.

Polymers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.

Background: Recent studies have suggested that both poly(l-lactide--1,5-dioxepan-2-one) (or poly(LLA--DXO)) and poly(l-lactide--ε-caprolactone) (or poly(LLA--CL)) porous scaffolds are good candidates for use as biodegradable scaffold materials in the field of tissue engineering; meanwhile, their surface properties, such as hydrophilicity, need to be further improved.

Methods: We applied several different concentrations of the surfactant Tween 80 to tune the hydrophilicity of both materials. Moreover, the modification was applied not only in the form of solid scaffold as a film but also a porous scaffold. Read More

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http://dx.doi.org/10.3390/polym12071453DOI Listing

Antimicrobial Activity of Electrospun Polyvinyl Alcohol Nanofibers Filled with Poly[2-(tert-butylaminoethyl) Methacrylate]-Grafted Graphene Oxide Nanosheets.

Polymers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.

A novel cationic polymer, poly[2-(tert-butylaminoethyl) methacrylate] (PTA), effectively kills various strains of bacteria with low toxicity to tissue cells. Graphene-based materials demonstrate exceptional electron transport capability, antibacterial activity, favorable nontoxicity, and versatile applicability. PTA can be grafted onto the graphene oxide (GO) surface (GO-g-PTA) to enhance the antimicrobial efficiency of the latter against (). Read More

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http://dx.doi.org/10.3390/polym12071449DOI Listing

Sol-Gel Synthesis, Physico-Chemical and Biological Characterization of Cerium Oxide/Polyallylamine Nanoparticles.

Polymers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 144961-4535, Iran.

Cerium oxide nanoparticles (CeO-NPs) have great applications in different industries, including nanomedicine. However, some studies report CeO-NPs-related toxicity issues that limit their usage and efficiency. In this study, the sol-gel method was applied to the synthesis of CeO-NPs using poly(allylamine) (PAA) as a capping and/or stabilizing agent. Read More

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http://dx.doi.org/10.3390/polym12071444DOI Listing

Microstructural Development and Rheological Study of a Nanocomposite Gel Polymer Electrolyte Based on Functionalized Graphene for Dye-Sensitized Solar Cells.

Polymers (Basel) 2020 Jun 27;12(7). Epub 2020 Jun 27.

Department of Chemistry, Materials and Chemical Engineering "Giulio Natta," Politecnico di Milano, 20131 Milano, Italy.

For a liquid electrolyte-based dye-sensitized solar cell (DSSC), long-term device instability is known to negatively affect the ionic conductivity and cell performance. These issues can be resolved by using the so called quasi-solid-state electrolytes. Despite the enhanced ionic conductivity of graphene nanoplatelets (GNPs), their inherent tendency toward aggregation has limited their application in quasi-solid-state electrolytes. Read More

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http://dx.doi.org/10.3390/polym12071443DOI Listing

Characterization, Biocompatibility, and Optimization of Electrospun SF/PCL/CS Composite Nanofibers.

Polymers (Basel) 2020 Jun 27;12(7). Epub 2020 Jun 27.

Department of Chemical and Materials Engineering, National Ilan University, Yilan 26047, Taiwan.

In this study, composite nanofibers (SF/PCL/CS) for the application of dressings were prepared with silk fibroin (SF), polycaprolactone (PCL), and chitosan (CS) by electrospinning techniques, and the effect of the fiber diameter was investigated using the three-stage Taguchi experimental design method (L9). Nanofibrous scaffolds were characterized by the combined techniques of scanning electron microscopy (SEM) and transmission electron microscopy (TEM), a cytotoxicity test, proliferation tests, the antimicrobial activity, and the equilibrium water content. A signal-to-noise ratio (S/N) analysis indicated that the contribution followed the order of SF to PCL > flow rate > applied voltage > CS addition, possibly owing to the viscosity and formation of the beaded fiber. Read More

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http://dx.doi.org/10.3390/polym12071439DOI Listing

Superior X-ray Radiation Shielding Effectiveness of Biocompatible Polyaniline Reinforced with Hybrid Graphene Oxide-Iron Tungsten Nitride Flakes.

Polymers (Basel) 2020 Jun 23;12(6). Epub 2020 Jun 23.

Nanotechnology & Catalysis Research Center, University of Malaya, Kuala Lumpur 50603, Malaysia.

X-ray radiation is a harmful carcinogenic electromagnetic source that can adversely affect the health of living species and deteriorate the DNA of cells, thus it's vital to protect vulnerable sources from them. To address this flaw, the conductive polymeric structure of polyaniline (PANi) was reinforced with diverse filler loadings (i.e. Read More

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http://dx.doi.org/10.3390/polym12061407DOI Listing

Graphene Nanoplatelets for the Development of Reinforced PLA-PCL Electrospun Fibers as the Next-Generation of Biomedical Mats.

Polymers (Basel) 2020 Jun 21;12(6). Epub 2020 Jun 21.

Department of Drug Sciences, University of Pavia, V.le Taramelli 12-27100 Pavia, Italy.

Electrospun scaffolds made of nano- and micro-fibrous non-woven mats from biodegradable polymers have been intensely investigated in recent years. In this field, polymer-based materials are broadly used for biomedical applications since they can be managed in high scale, easily shaped, and chemically changed to tailor their specific biologic properties. Nonetheless polymeric materials can be reinforced with inorganic materials to produce a next-generation composite with improved properties. Read More

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http://dx.doi.org/10.3390/polym12061390DOI Listing

Synthesis and Characterization of a 2,3-Dialkoxynaphthalene-Based Conjugated Copolymer via Direct Arylation Polymerization (DAP) for Organic Electronics.

Polymers (Basel) 2020 Jun 19;12(6). Epub 2020 Jun 19.

Research Laboratory for Organic Polymers (RLOP), Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.

Poly[(5,5'-(2,3-bis(2-ethylhexyloxy)naphthalene-1,4-diyl)bis(thiophene-2,2'-diyl))--(2,1,3-benzothiadiazole-4,7-diyl)] (PEHONDTBT) was synthesized for the first time and through direct arylation polymerization (DAP) for use as p-donor material in organic solar cells. Optimized reaction protocol leads to a donor-acceptor conjugated polymer in good yield, with less structural defects than its analog obtained from Suzuki polycondensation, and with similar or even higher molecular weight than other previously reported polymers based on the 2,3-dialkoxynaphthalene monomer. The batch-to-batch repeatability of the optimized DAP conditions for the synthesis of PEHONDTBT was proved, showing the robustness of the synthetic strategy. Read More

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http://dx.doi.org/10.3390/polym12061377DOI Listing

Mechanical Properties and Chemical Durability of Nafion/Sulfonated Graphene Oxide/Cerium Oxide Composite Membranes for Fuel-Cell Applications.

Polymers (Basel) 2020 Jun 18;12(6). Epub 2020 Jun 18.

School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea.

To improve both the mechanical and chemical durability of Nafion membranes for polymer electrolyte membrane fuel-cells (PEMFCs), Nafion composite membranes containing sulfonated graphene oxide (SGO) and cerium oxide (CeO; ceria) were prepared by solution casting. The structure and chemical composition of SGO were investigated by FT-IR and XPS. The effect of the sulfonation, addition of SGO and ceria on the mechanical properties, proton conductivity, and chemical stability were evaluated. Read More

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http://dx.doi.org/10.3390/polym12061375DOI Listing

A Deep Insight into Different Acidic Additives as Doping Agents for Enhancing Proton Conductivity on Polybenzimidazole Membranes.

Polymers (Basel) 2020 Jun 18;12(6). Epub 2020 Jun 18.

Departamento de Termodinámica Aplicada, Escuela Técnica Superior de Ingeniería Industrial, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.

The use of phosphoric acid doped polybenzimidazole (PBI) membranes for fuel cell applications has been extensively studied in the past decades. In this article, we present a systematic study of the physicochemical properties and proton conductivity of PBI membranes doped with the commonly used phosphoric acid at different concentrations (0.1, 1, and 14 M), and with other alternative acids such as phytic acid (0. Read More

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http://dx.doi.org/10.3390/polym12061374DOI Listing

Role of Changes in State of Bound Water and Tissue Stiffness in Development of Age-Related Diseases.

Authors:
Garry Kerch

Polymers (Basel) 2020 Jun 17;12(6). Epub 2020 Jun 17.

Faculty of Materials Science and Applied Chemistry, Riga Technical University, 1048 Riga, Latvia.

An essential effect of environmental stiffness on biological processes in cells at present is generally accepted. An increase in arterial stiffness with advanced age has been reported in many publications. The aim of the present review is to summarize current information about possible chemical reactions and physical processes that lead to tissue stiffening and result in age-related diseases in order to find methods that can prevent or retard time-dependent tissue stiffening. Read More

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http://dx.doi.org/10.3390/polym12061362DOI Listing

Light Processable Starch Hydrogels.

Polymers (Basel) 2020 Jun 17;12(6). Epub 2020 Jun 17.

Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden.

Light processable hydrogels were successfully fabricated by utilizing maize starch as raw material. To render light processability, starch was gelatinized and methacrylated by simple reaction with methacrylic anhydride. The methacrylated starch was then evaluated for its photocuring reactivity and 3D printability by digital light processing (DLP). Read More

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http://dx.doi.org/10.3390/polym12061359DOI Listing

Crosslinked Sulfonated Polyphenylsulfone-Vinylon (CSPPSU-vinylon) Membranes for PEM Fuel Cells from SPPSU and Polyvinyl Alcohol (PVA).

Polymers (Basel) 2020 Jun 16;12(6). Epub 2020 Jun 16.

Functional Clay Materials Group, Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

A crosslinked sulfonated polyphenylsulfone (CSPPSU) polymer and polyvinyl alcohol (PVA) were thermally crosslinked; then, a CSPPSU-vinylon membrane was synthesized using a formalization reaction. Its use as an electrolyte membrane for fuel cells was investigated. PVA was synthesized from polyvinyl acetate (PVAc), using a saponification reaction. Read More

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http://dx.doi.org/10.3390/polym12061354DOI Listing

Solar Cells for Indoor Applications: Progress and Development.

Polymers (Basel) 2020 Jun 12;12(6). Epub 2020 Jun 12.

School of Electrical and Computer Engineering, Institute of Information Technology, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-gu, Seoul 02504, Korea.

The Internet of things (IoT) has been rapidly growing in the past few years. IoT connects numerous devices, such as wireless sensors, actuators, and wearable devices, to optimize and monitor daily activities. Most of these devices require power in the microwatt range and operate indoors. Read More

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http://dx.doi.org/10.3390/polym12061338DOI Listing

Solid Polymer Electrolytes with Flexible Framework of SiO Nanofibers for Highly Safe Solid Lithium Batteries.

Polymers (Basel) 2020 Jun 10;12(6). Epub 2020 Jun 10.

College of Physics, Qingdao University, Qingdao 266071, China.

Composite electrolytes consisting of polymers and three-dimensional (3D) fillers are considered to be promising electrolytes for solid lithium batteries owing to their virtues of continuous lithium-ion pathways and good mechanical properties. In the present study, an electrolyte with polyethylene oxide-lithium (bis trifluoromethyl) sulfate-succinonitrile (PLS) and frameworks of three-dimensional SiO nanofibers (3D SiO NFs) was prepared. Taking advantage of the highly conductive interfaces between 3D SiO NFs and PLS, the total conductivity of the electrolyte at 30 °C was approximately 9. Read More

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http://dx.doi.org/10.3390/polym12061324DOI Listing

Using Finite Element Approach for Crashworthiness Assessment of a Polymeric Auxetic Structure Subjected to the Axial Loading.

Polymers (Basel) 2020 Jun 9;12(6). Epub 2020 Jun 9.

Institute for Nanomaterials, Advanced Technologies and Innovation (CXI), Technical University of Liberec (TUL), Studentska 2, 461 17 Liberec, Czech Republic.

Polyurethane foams are one of the most common auxetic structures regarding energy absorption enhancement. This present study evaluates the result reliability of two different numerical approaches, the H-method and the P-method, to obtain the best convergence solution. A polymeric re-entrant cell is created with a beam element and the results of the two different methods are compared. Read More

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http://dx.doi.org/10.3390/polym12061312DOI Listing

Antimicrobial Properties of Polyaniline and Polypyrrole Decorated with Zinc-Doped Copper Oxide Microparticles.

Polymers (Basel) 2020 Jun 4;12(6). Epub 2020 Jun 4.

Bar-Ilan Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.

Polyaniline (PANI) and polypyrrole (PPY) were synthesized by carbon dots (CDs) under UV irradiation and then sonicated together with zinc acetate and copper acetate to form the PANI-Zn@CuO and PPY-Zn@Cu composites. The former consisted of agglomerated spherical particles with diameters of 1-5 µm, whereas the latter displayed irregular stick shapes with similar diameters. The bacterial potency of the composites against and was enhanced remarkably with Zn doping in the CuO matrix, designated as ZnCuO, at 0. Read More

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http://dx.doi.org/10.3390/polym12061286DOI Listing

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges.

Polymers (Basel) 2020 Jun 1;12(6). Epub 2020 Jun 1.

Department of Chemical Engineering, Centre for Mechanical Engineering, Materials and Processes, University of Coimbra, Rua Sílvio Lima-Polo II, 3030-790 Coimbra, Portugal.

The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell-cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Read More

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http://dx.doi.org/10.3390/polym12061268DOI Listing

Characterization and Therapeutic Effect of a pH Stimuli Responsive Polymeric Nanoformulation for Controlled Drug Release.

Polymers (Basel) 2020 Jun 1;12(6). Epub 2020 Jun 1.

GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain.

Despite the large number of polymeric nanodelivery systems that have been recently developed, there is still room for improvement in terms of therapeutic efficiency. Most reported nanodevices for controlled release are based on drug encapsulation, which can lead to undesired drug leakage with a consequent reduction in efficacy and an increase in systemic toxicity. Herein, we present a strategy for covalent drug conjugation to the nanodevice to overcome this drawback. Read More

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http://dx.doi.org/10.3390/polym12061265DOI Listing

Quantifying Oxygen Levels in 3D Bioprinted Cell-Laden Thick Constructs with Perfusable Microchannel Networks.

Polymers (Basel) 2020 May 30;12(6). Epub 2020 May 30.

Regenerative Medicine and Cellular Therapies Group, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.

The survival and function of thick tissue engineered implanted constructs depends on pre-existing, embedded, functional, vascular-like structures that are able to integrate with the host vasculature. Bioprinting was employed to build perfusable vascular-like networks within thick constructs. However, the improvement of oxygen transportation facilitated by these vascular-like networks was directly quantified. Read More

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http://dx.doi.org/10.3390/polym12061260DOI Listing
May 2020
2.505 Impact Factor

Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications.

Polymers (Basel) 2020 May 29;12(6). Epub 2020 May 29.

Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. Read More

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http://dx.doi.org/10.3390/polym12061233DOI Listing

Multifunctional and Transformable 'Clickable' Hydrogel Coatings on Titanium Surfaces: From Protein Immobilization to Cellular Attachment.

Polymers (Basel) 2020 May 26;12(6). Epub 2020 May 26.

Department of Chemistry, Bogazici University, Bebek, Istanbul 34342, Turkey.

Multifunctionalizable hydrogel coatings on titanium interfaces are useful in a wide range of biomedical applications utilizing titanium-based materials. In this study, furan-protected maleimide groups containing multi-clickable biocompatible hydrogel layers are fabricated on a titanium surface. Upon thermal treatment, the masked maleimide groups within the hydrogel are converted to thiol-reactive maleimide groups. Read More

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http://dx.doi.org/10.3390/polym12061211DOI Listing

Doxycycline and Zinc Loaded Silica-Nanofibrous Polymers as Biomaterials for Bone Regeneration.

Polymers (Basel) 2020 May 25;12(5). Epub 2020 May 25.

Oral Surgery Section, Faculty of Dentistry, University of Sevilla, Avicena s/n, 41009 Sevilla, Spain.

The main target of bone tissue engineering is to design biomaterials that support bone regeneration and vascularization. Nanostructured membranes of (MMA)-co-(HEMA)/(MA)-co-(HEA) loaded with 5% wt of SiO-nanoparticles (HOOC-Si-Membrane) were doped with zinc (Zn-HOOC-Si-Membrane) or doxycycline (Dox-HOOC-Si-Membrane). Critical bone defects were effectuated on six New Zealand-bred rabbit skulls and covered with the membranes. Read More

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http://dx.doi.org/10.3390/polym12051201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285172PMC

Positively Charged Polymers as Promising Devices against Multidrug Resistant Gram-Negative Bacteria: A Review.

Polymers (Basel) 2020 May 23;12(5). Epub 2020 May 23.

Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Viale Benedetto XV, 6, I-16132 Genova, Italy.

Antibiotic resistance has increased markedly in Gram-negative bacteria, causing severe infections intractable with traditional drugs and amplifying mortality and healthcare costs. Consequently, to find novel antimicrobial compounds, active on multidrug resistant bacteria, is mandatory. In this regard, cationic antimicrobial peptides (CAMPs)-able to kill pathogens on contact-could represent an appealing solution. Read More

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http://dx.doi.org/10.3390/polym12051195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285334PMC

A Facile Fabrication of Biodegradable and Biocompatible Cross-Linked Gelatin as Screen Printing Substrates.

Polymers (Basel) 2020 May 22;12(5). Epub 2020 May 22.

Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan.

This study focuses on preparation and valuation of the biodegradable, native, and modified gelatin film as screen-printing substrates. Modified gelatin film was prepared by crosslinking with various crosslinking agents and the electrode array was designed by screen-printing. It was observed that the swelling ratio of C-2, crosslinked with glutaraldehyde and EDC/NHS (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide) was found to be lower (3. Read More

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http://dx.doi.org/10.3390/polym12051186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284702PMC

Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology.

Polymers (Basel) 2020 May 21;12(5). Epub 2020 May 21.

Secció de Bioquímica i Biologia Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Joan XXIII 27-31, 08028 Barcelona, Spain.

Chitosan is increasingly used for safe nucleic acid delivery in gene therapy studies, due to well-known properties such as bioadhesion, low toxicity, biodegradability and biocompatibility. Furthermore, chitosan derivatization can be easily performed to improve the solubility and stability of chitosan-nucleic acid polyplexes, and enhance efficient target cell drug delivery, cell uptake, intracellular endosomal escape, unpacking and nuclear import of expression plasmids. As in other fields, chitosan is a promising drug delivery vector with great potential for the fish farming industry. Read More

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http://dx.doi.org/10.3390/polym12051177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285272PMC

Collagen Scaffolds Containing Hydroxyapatite-CaO Fiber Fragments for Bone Tissue Engineering.

Polymers (Basel) 2020 May 20;12(5). Epub 2020 May 20.

Department of Bioscience and Biotechnology, National Taiwan Ocean University; Keelung City 202301, Taiwan.

Collagen (COL) and hydroxyapatite (HAp) are the major components of bone, therefore, COL-HAp composites have been widely used as bone substitutes to promote bone regeneration. We have reported that HAp-CaO fibers (HANFs), which were fabricated by a sol-gel route followed by an electrospinning technique, possessed good drug-loading efficiency and limited the burst release of tetracycline. In the present study, we used HANF fragments to evaluate the effects of COL-HANF scaffolds on MG63 osteoblast-like cell behaviors. Read More

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http://dx.doi.org/10.3390/polym12051174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284761PMC

Kinetics of Cross-Linking Reaction of Epoxy Resin with Hydroxyapatite-Functionalized Layered Double Hydroxides.

Polymers (Basel) 2020 May 18;12(5). Epub 2020 May 18.

Department of Resin and Additives, Institute for Color Science and Technology, P.O. Box 16765-654, Tehran, Iran.

The cure kinetics analysis of thermoset polymer composites gives useful information about their properties. In this work, two types of layered double hydroxide (LDH) consisting of Mg and Zn as divalent metal ions and CO as an anion intercalating agent were synthesized and functionalized with hydroxyapatite (HA) to make a potential thermal resistant nanocomposite. The curing potential of the synthesized nanoplatelets in the epoxy resin was then studied, both qualitatively and quantitatively, in terms of the as well as using isoconversional methods, working on the basis of nonisothermal differential scanning calorimetry (DSC) data. Read More

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http://dx.doi.org/10.3390/polym12051157DOI Listing

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering.

Polymers (Basel) 2020 May 18;12(5). Epub 2020 May 18.

Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 144961-4535, Iran.

The lack of adequate blood/lymphatic vessels as well as low-potential articular cartilage regeneration underlines the necessity to search for alternative biomaterials. Owing to their unique features, such as reversible thermogelling behavior and tissue-like mechanical behavior, agarose-based biomaterials have played a key role in cartilage tissue repair. Accordingly, the need for fabricating novel highly efficient injectable agarose-based biomaterials as hydrogels for restoration of injured cartilage tissue has been recognized. Read More

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http://dx.doi.org/10.3390/polym12051150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285176PMC
May 2020
2.505 Impact Factor

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials.

Polymers (Basel) 2020 May 19;12(5). Epub 2020 May 19.

Department of Biochemistry, Faculty of Veterinary Medicine, University of Agronomic Science and Veterinary Medicine, 011464 Bucharest, Romania.

This paper proposes the development of a biomimetic composite based on naturally derived biomaterials. This freeze-dried scaffold contains a microwave-synthesized form of biomimetic hydroxyapatite (HAp), using the interwoven hierarchical structure of eggshell membrane (ESM) as bio-template. The bone regeneration capacity of the scaffold is enhanced with the help of added tricalcium phosphate from bovine Bone ash (BA). Read More

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http://dx.doi.org/10.3390/polym12051161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284724PMC

Redox-Responsive Coordination Polymers of Dopamine-Modified Hyaluronic Acid with Copper and 6-Mercaptopurine for Targeted Drug Delivery and Improvement of Anticancer Activity against Cancer Cells.

Authors:
Bo Tao Zongning Yin

Polymers (Basel) 2020 May 14;12(5). Epub 2020 May 14.

Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.

Dopamine-modified hyaluronic acid (HA-DOP) was chosen as the drug carrier in this study, and Cu was selected from among Cu, Zn, Fe, and Ca as the central atom. 6-Mercaptopurine (6-MP) was conjugated with HA through a coordination reaction. HA-DOP-copper-MP (HA-DOP-Cu-MP), a redox-responsive coordination polymer prodrug, was prepared. Read More

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http://dx.doi.org/10.3390/polym12051132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285144PMC

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats.

Polymers (Basel) 2020 May 14;12(5). Epub 2020 May 14.

Department of Hospital Surgery №1, N.I. Pirogov Russian National Research Medical University (RNRMU), Ostrovityanova St., 1, 117997 Moscow, Russia.

High-quality and aesthetic wound healing, as well as effective medical support of this process, continue to be relevant. This study aims to evaluate the medical efficacy of a novel smart polymeric nanodrug (SPN) on the rate and mechanism of wound healing in experimental animals. The study was carried out in male Wistar rats (aged 8-9 months). Read More

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http://dx.doi.org/10.3390/polym12051126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285345PMC

Fabrication of Poly(ethylene glycol) Capsules via Emulsion Templating Method for Targeted Drug Delivery.

Polymers (Basel) 2020 May 14;12(5). Epub 2020 May 14.

Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

To reduce nonspecific interactions and circumvent biological barriers, low-fouling material of poly(ethylene glycol) (PEG) is most used for the modification of drug nanocarriers. Herein, we report the fabrication of PEG capsules via the free-radical polymerization of linear PEG or 8-arm-PEG using an emulsion templating method for targeted drug delivery. Doxorubicin (DOX) could be loaded in capsules via electrostatic interactions. Read More

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http://dx.doi.org/10.3390/polym12051124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285215PMC

Graphene Oxide Composite for Selective Recognition, Capturing, Photothermal Killing of Bacteria over Mammalian Cells.

Polymers (Basel) 2020 May 13;12(5). Epub 2020 May 13.

Key Laboratory of Hebei Province for Molecular Biophysics, Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China.

The multifunctional photothermal therapy (PTT) platform with the ability to selectively kill bacteria over mammalian cells has received widespread attention recently. Herein, we prepared graphene oxide-amino(polyethyleneglycol) (GO-PEG-NH) while using the hydrophobic interaction between heptadecyl end groups of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethyleneglycol)] (DSPE-PEG-NH) and graphene oxide (GO). Based on GO-PEG-NH, the versatile PTT system was constructed with simultaneous selective recognition, capturing, and photothermal killing of bacteria. Read More

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http://dx.doi.org/10.3390/polym12051116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285330PMC

Maleamic Acid as an Organic Anode Material in Lithium-Ion Batteries.

Polymers (Basel) 2020 May 13;12(5). Epub 2020 May 13.

Graduate School of Biochemical Engineering, Ming Chi University of Technology, New-Taipei City 243, Taiwan.

Low-molecular-weight carbonyl-containing compounds are considered beneficial energy storage materials in alkali metal-ion/alkaline earth metal-ion secondary batteries owing to the ease of their synthesis, low cost, rapid kinetics, and high theoretical energy density. This study aims to prepare a novel carbonyl compound containing a maleamic acid (MA) backbone as a material with carbon black to a new MA anode electrode for a lithium-ion battery. MA was subjected to attenuated total reflection-Fourier-transform infrared spectroscopy, and its morphology was assessed through scanning electron microscopy, followed by differential scanning calorimetry to determine its thermal stability. Read More

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http://dx.doi.org/10.3390/polym12051109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285370PMC

Electrospun Silk-Boron Nitride Nanofibers with Tunable Structure and Properties.

Authors:
Ye Xue Xiao Hu

Polymers (Basel) 2020 May 11;12(5). Epub 2020 May 11.

Department of Physics & Astronomy, Rowan University, Glassboro, NJ 08028, USA.

In this study, hexagonal boron nitride (h-BN) nanosheets and silk fibroin (SF) proteins were combined and electrospun into BNSF nanofibers with different ratios. It was found that the surface morphology and crosslinking density of the nanofibers can be tuned through the mixing ratios. Fourier transform infrared spectroscopy study showed that pure SF electrospun fibers were dominated by random coils and they gradually became α-helical structures with increasing h-BN nanosheet content, which indicates that the structure of the nanofiber material is tunable. Read More

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http://dx.doi.org/10.3390/polym12051093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284470PMC

Physical and Biological Evaluation of Low-Molecular-Weight Hyaluronic Acid/FeO Nanoparticle for Targeting MCF7 Breast Cancer Cells.

Polymers (Basel) 2020 May 11;12(5). Epub 2020 May 11.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Low-molecular-weight hyaluronic acid (LMWHA) was integrated with superparamagnetic FeO nanoparticles (FeO NPs). The size distribution, zeta potential, viscosity, thermogravimetric and paramagnetic properties of the LMWHA-FeO NPs were systematically examined. For cellular experiments, MCF7 breast cancer cell line was carried out. Read More

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http://dx.doi.org/10.3390/polym12051094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285014PMC

Photosensitive Poly-l-lysine/Heparin Interpolyelectrolyte Complexes for Delivery of Genetic Drugs.

Polymers (Basel) 2020 May 8;12(5). Epub 2020 May 8.

Institute of Chemistry, Saint Petersburg State University, St. Petersburg, Universitetskii pr. 26, Peterhoff 198504, Russia.

Photo-triggered release of biopharmaceutical drugs inside the cells is a challenging direction of modern science, which requires obtaining new polymeric systems. The interpolyelectrolyte complexes (IPECs) of poly-l-lysine with heparin capable of encapsulation of genetic constructions-such as model oligonucleotide, siRNA, and pDNA-were obtained. Poly-l-lysine to heparin ratios were optimized to provide the appropriate release kinetics of genetic material from the polyplex. Read More

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http://dx.doi.org/10.3390/polym12051077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285230PMC

Water-Soluble Photoinitiators in Biomedical Applications.

Polymers (Basel) 2020 May 7;12(5). Epub 2020 May 7.

Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24, 31-155 Cracow, Poland.

Light-initiated polymerization processes are currently an important tool in various industrial fields. The advancement of technology has resulted in the use of photopolymerization in various biomedical applications, such as the production of 3D hydrogel structures, the encapsulation of cells, and in drug delivery systems. The use of photopolymerization processes requires an appropriate initiating system that, in biomedical applications, must meet additional criteria such as high water solubility, non-toxicity to cells, and compatibility with visible low-power light sources. Read More

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http://dx.doi.org/10.3390/polym12051073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285382PMC

Recent Progress in the Development of Aromatic Polymer-Based Proton Exchange Membranes for Fuel Cell Applications.

Polymers (Basel) 2020 May 6;12(5). Epub 2020 May 6.

Graphene and Advanced 2D Materials Research Group (GAMRG), School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia.

Proton exchange membranes (PEMs) play a pivotal role in fuel cells; conducting protons from the anode to the cathode within the cell's membrane electrode assembles (MEA) separates the reactant fuels and prevents electrons from passing through. High proton conductivity is the most important characteristic of the PEM, as this contributes to the performance and efficiency of the fuel cell. However, it is also important to take into account the membrane's durability to ensure that it canmaintain itsperformance under the actual fuel cell's operating conditions and serve a long lifetime. Read More

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http://dx.doi.org/10.3390/polym12051061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285229PMC

Effect of Double Substitution in Cationic Chitosan Derivatives on DNA Transfection Efficiency.

Polymers (Basel) 2020 May 5;12(5). Epub 2020 May 5.

Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoi pr. VO 31, 199004 St. Petersburg, Russia.

Recently, much effort has been expended on the development of non-viral gene delivery systems based on polyplexes of nucleic acids with various cationic polymers. Natural polysaccharide derivatives are promising carriers due to their low toxicity. In this work, chitosan was chemically modified by a reaction with 4-formyl--trimethylanilinium iodide and pyridoxal hydrochloride and subsequent reduction of the imine bond with NaBH. Read More

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http://dx.doi.org/10.3390/polym12051057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284465PMC

Polycaprolactone Films Modified by L-Arginine for Mesenchymal Stem Cell Cultivation.

Polymers (Basel) 2020 May 2;12(5). Epub 2020 May 2.

Center of Cell Technologies, Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky pr. 4, St. Petersburg 194064, Russia.

This article describes the modification conditions and properties of polymer films obtained using a solution of poly(ε-caprolactone) modified with arginine. We investigated the effects on the surface and biological properties of films created using various arginine concentrations and temperature conditions during the modification process. We found that both increasing the arginine concentration of the treatment solution or the temperature of the treatment reaction increased the arginine content of the film. Read More

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http://dx.doi.org/10.3390/polym12051042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284497PMC