542 results match your criteria Cellular Oncology[Journal]


The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour.

Anal Cell Pathol (Amst) 2020 28;2020:8232803. Epub 2020 May 28.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1155/2020/8232803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275214PMC

Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth.

Anal Cell Pathol (Amst) 2020 13;2020:6128341. Epub 2020 May 13.

Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Background: Nifedipine-induced gingival overgrowth (NGO) is a multifactorial pathogenesis with increased extracellular matrix including collagen and glycans, inflammatory cytokines, and phenotype changes of fibroblasts. However, the molecular etiology of NGO is not well understood. The objective of this study is to investigate the key genes in the pathogenesis of NGO. Read More

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http://dx.doi.org/10.1155/2020/6128341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242917PMC

Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension.

Anal Cell Pathol (Amst) 2020 22;2020:8927381. Epub 2020 Jan 22.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA.

Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chronic hypoxia mice. Epoxyeicosatrienoic acid (EET) is an endogenous agonist of TRPV4 and is known to regulate vasoreactivity. Read More

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http://dx.doi.org/10.1155/2020/8927381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204149PMC
January 2020

Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney Injury.

Anal Cell Pathol (Amst) 2020 1;2020:8576234. Epub 2020 May 1.

Department of Emergency, Shanghai Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China 200011.

Objective: To investigate the effects of lncRNA CRNDE on sepsis-associated acute kidney injury in the human kidney 2 cell line and explore the potential mechanisms.

Methods: HK-2 cells were treated with lipopolysaccharides to induce injuries. The expression of CRNDE and miR-146a in HK-2 cells were altered by a transient transfection assay. Read More

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http://dx.doi.org/10.1155/2020/8576234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211233PMC
May 2020
1.758 Impact Factor

A New Era for Analytical Cellular Pathology.

Anal Cell Pathol (Amst) 2020 14;2020:8502160. Epub 2020 Jan 14.

Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1155/2020/8502160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201488PMC
January 2020

Metformin: A Possible Option in Cancer Chemotherapy.

Anal Cell Pathol (Amst) 2020 27;2020:7180923. Epub 2020 Apr 27.

Ebonyi State University, Abakaliki, Nigeria.

Metformin has been used for a long time as an antidiabetic medication for type 2 diabetes. It is used either as a monotherapy or in combination with other antidiabetic medications. The drug came into prominence in diabetes and other conditions with cardiovascular risk after the landmark study of 1995 by the United Kingdom Prospective Diabetes Study which emphasized its importance. Read More

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http://dx.doi.org/10.1155/2020/7180923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201450PMC

Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.

Anal Cell Pathol (Amst) 2020 20;2020:9268236. Epub 2020 Apr 20.

Unit of Pharmacogenomics, Department of Genetics, Institut Curie, F-75248 Paris, France.

Epidermal growth factor receptor (EGFR) signalling is a highly regulated process with a tight balance between receptor activation and inactivation in invasive breast carcinomas (IBCs) particularly in triple-negative carcinomas (TNC). Clinical trials using anti-EGFR therapies are actually performed although no activating alterations (mutations, amplifications, or rearrangements) of have been clearly recognized in order to identify new targeted modalities for IBCs. We explored mammary-derived growth inhibitor (MDGI), estrogen-induced gene-121 (EIG121), and mitogen-induced gene-6 (MIG6), three posttranslational EGFR trafficking molecules implicated in EGFR spatiotemporal regulatory pathway. Read More

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http://dx.doi.org/10.1155/2020/9268236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189325PMC

Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers.

Anal Cell Pathol (Amst) 2020 8;2020:6283796. Epub 2020 Jan 8.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China.

Tumors are surrounded by complex environmental components, including blood and lymph vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and extracellular matrix. All the stromal components together with the tumor cells form the tumor microenvironment (TME). In addition, extracellular physical and chemical factors, including extracellular pH, hypoxia, elevated interstitial fluid pressure, and fibrosis, are closely associated with tumor progression, metastasis, immunosuppression, and drug resistance. Read More

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http://dx.doi.org/10.1155/2020/6283796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199555PMC
January 2020

The Role of Rho GTPases in VEGF Signaling in Cancer Cells.

Anal Cell Pathol (Amst) 2020 16;2020:2097214. Epub 2020 Apr 16.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.

Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules' binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). Read More

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http://dx.doi.org/10.1155/2020/2097214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182966PMC

Morphological Characteristics and Correction of Long Tubular Bone Regeneration under Chronic Hyperglycemia Influence.

Anal Cell Pathol (Amst) 2020 6;2020:5472841. Epub 2020 Apr 6.

Sumy State University, Sumy, Ukraine.

Introduction: Unsatisfactory consequences of bone regeneration disorders in diabetes mellitus (DM) patients, their high prevalence, complication number, and difficulties in treatment require further study and deeper understanding of reparative osteogenesis mechanisms under chronic hyperglycemia and finding new effective and affordable approaches to their treatment. Therefore, the aim of our work was to study the histological, ultramicroscopic, and histomorphometric features of reparative osteogenesis in rats with chronic hyperglycemia (CH), as well as to investigate the possibility of platelet-rich plasma (PRP) use in a fracture area in order to correct the negative effects of CH on reparative osteogenesis processes. . Read More

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http://dx.doi.org/10.1155/2020/5472841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165321PMC

KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma.

Anal Cell Pathol (Amst) 2020 3;2020:6403012. Epub 2020 Apr 3.

Department of Clinical Laboratory, Tianjin Second People's Hospital, Tianjin Institute of Hepatology, No. 75, Sudi Road, Nankai District, Tianjin City 530031, China.

Liver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer. Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world. Recently, molecular targeted therapies showed great promise in the treatment of HCC, and novel molecular therapeutic targets is urgently needed. Read More

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http://dx.doi.org/10.1155/2020/6403012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157793PMC

Molecular and Cellular Mechanisms Responsible for Beneficial Effects of Mesenchymal Stem Cell-Derived Product "Exo-d-MAPPS" in Attenuation of Chronic Airway Inflammation.

Anal Cell Pathol (Amst) 2020 20;2020:3153891. Epub 2020 Mar 20.

Center for Molecular Medicine and Stem Cell Research, Department for Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.

Mesenchymal stem cells (MSCs), due to their potential for differentiation into alveolar epithelial cells and their immunosuppressive characteristics, are considered a new therapeutic agent in cell-based therapy of inflammatory lung disorders, including chronic obstructive pulmonary disease (COPD). Since most of the MSC-mediated beneficent effects were the consequence of their paracrine action, herewith, we investigated the effects of a newly designed MSC-derived product "Exosome-derived Multiple Allogeneic Protein Paracrine Signaling (Exo-d-MAPPS)" in the attenuation of chronic airway inflammation by using an animal model of COPD (induced by chronic exposure to cigarette smoke (CS)) and clinical data obtained from Exo-d-MAPPS-treated COPD patients. Exo-d-MAPPS contains a high concentration of immunomodulatory factors which are capable of attenuating chronic airway inflammation, including soluble TNF receptors I and II, IL-1 receptor antagonist, and soluble receptor for advanced glycation end products. Read More

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http://dx.doi.org/10.1155/2020/3153891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109559PMC

Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.

Anal Cell Pathol (Amst) 2020 3;2020:1827676. Epub 2020 Mar 3.

Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun 130021, China.

Purpose: To examine the expression of RAD51 in oral squamous cell carcinoma (OSCC) and analyze its connection with pathological grade, clinical stage, and lymphatic metastasis potential.

Methods: For this study, 74 OSCC samples, 15 normal mucosa tissues, and 11 normal skin tissue samples were collected. RAD51 expression was investigated using immunohistochemistry. Read More

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http://dx.doi.org/10.1155/2020/1827676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072096PMC

The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells.

Anal Cell Pathol (Amst) 2020 31;2020:9274016. Epub 2020 Jan 31.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut-, Lebanon.

Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells. Read More

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http://dx.doi.org/10.1155/2020/9274016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013281PMC
January 2020

Diagnosis, Therapy, and Prognosis for Hepatocellular Carcinoma.

Anal Cell Pathol (Amst) 2020;2020:8157406. Epub 2020 Feb 3.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

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http://dx.doi.org/10.1155/2020/8157406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023837PMC
February 2020

MCMs in Cancer: Prognostic Potential and Mechanisms.

Anal Cell Pathol (Amst) 2020 3;2020:3750294. Epub 2020 Feb 3.

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University, Beijing 100084, China.

Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells. Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication initiation and play vital roles in controlling replication times within a cell cycle. Overexpressed MCMs are detected in various cancerous tissues and cancer cell lines. Read More

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http://dx.doi.org/10.1155/2020/3750294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023756PMC
February 2020
1.758 Impact Factor

Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study.

Anal Cell Pathol (Amst) 2019 30;2019:3085181. Epub 2019 Dec 30.

Pathology Department, Colentina University Hospital, Bucharest, Romania.

Chronic inflammation induced by () infection plays a major role in development of gastric cancer. However, recent findings suggested that progression of inflammation and neoplastic transformation in infection are more complex than previously believed and could involve different factors that modulate gastric microenvironment and influence host-pathogen interaction. Among these factors, gastric myenteric plexus and its potential adaptive changes in H. Read More

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http://dx.doi.org/10.1155/2019/3085181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012220PMC
December 2019

GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.

Anal Cell Pathol (Amst) 2019 30;2019:1038069. Epub 2019 Dec 30.

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University, Beijing 100084, China.

GTSE1 is well correlated with tumor progression; however, little is known regarding its role in liver cancer prognosis. By analyzing the hepatocellular carcinoma (HCC) datasets in GEO and TCGA databases, we showed that high expression of GTSE1 was correlated with advanced pathologic stage and poor prognosis of HCC patients. To investigate underlying molecular mechanism, we generated GTSE1 knockdown HCC cell line and explored the effects of GTSE1 deficiency in cell growth. Read More

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http://dx.doi.org/10.1155/2019/1038069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012210PMC
December 2019
1.758 Impact Factor

Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer.

Anal Cell Pathol (Amst) 2019 16;2019:9740475. Epub 2019 Dec 16.

Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Colorectal cancer (CRC) is one of the most frequent cancers occurring in developed countries. Distant CRC metastasis causes more than 90% of CRC-associated mortality. MicroRNAs (miRNAs) play a key role in regulating tumor metastasis and could be potential diagnostic biomarkers in CRC patients. Read More

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http://dx.doi.org/10.1155/2019/9740475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942701PMC
December 2019

Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis.

Anal Cell Pathol (Amst) 2019 16;2019:8586354. Epub 2019 Dec 16.

Faculty of Dental Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.

Diffuse large B-cell lymphoma (DLBCL) represents 30-40% of all non-Hodgkin lymphomas (NHL) and is a disease with an aggressive behavior. Because about one-third of DLBCL patients will be refractory or resistant to standard therapy, several studies focused on identification of new individual prognostic and risk stratification biomarkers and new potential therapeutic targets. In contrast to other types of cancers like carcinomas, where tumor microenvironment was widely investigated, its role in DLBCL pathogenesis and patient survival is still poorly understood, although few studies had promising results. Read More

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http://dx.doi.org/10.1155/2019/8586354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942707PMC
December 2019

Performance of HPV16/18 in Triage of Cytological Atypical Squamous Cells of Undetermined Significance.

Anal Cell Pathol (Amst) 2019 16;2019:4324710. Epub 2019 Dec 16.

Department of Cancer Epidemiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.

Context: Human papillomavirus (HPV) testing is widely used in cervical cancer screening in women; however, its efficiency in triaging women with atypical squamous cells of undetermined significance (ASC-US) needs to be validated.

Objective: To evaluate the performance of HPV16/18 in the triage of women with ASC-US.

Methods: Women presenting for routine cervical cancer screening had cervical specimens collected, with which both liquid-based cytology (LBC) and hrHPVs were examined; those with ASC-US cytology underwent colposcopy. Read More

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http://dx.doi.org/10.1155/2019/4324710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942702PMC
December 2019

Epithelial-Mesenchymal Transition in Skin Cancers: A Review.

Anal Cell Pathol (Amst) 2019 16;2019:3851576. Epub 2019 Dec 16.

"Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Epithelial-mesenchymal transition (EMT) is involved in physiologic processes such as embryogenesis and wound healing. A similar mechanism occurs in some tumors where cells leave the epithelial layer and gain mesenchymal particularities in order to easily migrate to other tissues. This process can explain the invasiveness and aggressiveness of these tumors which metastasize, by losing the epithelial phenotype (loss of E-cadherin, desmoplakin, and laminin-1) and acquiring mesenchymal markers (N-cadherin). Read More

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http://dx.doi.org/10.1155/2019/3851576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942705PMC
December 2019

Conditioned Medium from Adipose-Derived Stem Cell Inhibits Jurkat Cell Proliferation through TGF-1 and p38/MAPK Pathway.

Anal Cell Pathol (Amst) 2019 19;2019:2107414. Epub 2019 Dec 19.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Background: Since the first report on the immunomodulatory and immunosuppressive properties of Adipose-Derived Stem Cells (ADSCs), many studies have elucidated the underlying molecular mechanism of their suppressive activity on mixed lymphocyte reaction (MLR). However, a gap exists in our understanding of the molecular mechanism of ADSC-conditioned medium (ADSC-CM) on MLR.

Methods: ADSCs were isolated from Human Adipose Tissues, and Enzyme-linked Immunosorbent Assay (ELISA) was used to identify the concentration of transforming growth factor 1 (TGF-1) in ADSC-CM. Read More

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http://dx.doi.org/10.1155/2019/2107414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942699PMC
December 2019

Clinical Characteristics and Prognosis of Gastrointestinal Metastases in Solid Tumor Patients: A Retrospective Study and Review of Literatures.

Anal Cell Pathol (Amst) 2019 20;2019:4508756. Epub 2019 Dec 20.

Department of Oncology, Peking University International Hospital, Life Park of Zhongguancun, Changping District, Beijing, China 102206.

Background: According to the literature and our experience, patients with gastrointestinal metastases are relatively rare. Numerous case reports and literature reviews have been reported. We present one of the larger case series of gastrointestinal metastases. Read More

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http://dx.doi.org/10.1155/2019/4508756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939450PMC
December 2019

The Effect of Protein FAM172A on Proliferation in HepG2 Cells and Investigation of the Possible Molecular Mechanism.

Anal Cell Pathol (Amst) 2019 13;2019:5901083. Epub 2019 Dec 13.

Liver Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.

Background: In our previous study, we found that the FAM172A recombinant protein could promote proliferation of L02 cells. However, the underlying mechanisms are still unknown. The present study was aimed at investigating the effect of FAM172A on proliferation of HepG2 cells and exploring the possible molecular mechanisms and its role in hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1155/2019/5901083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930761PMC
December 2019

Differential Diagnosis of Autoimmune Encephalitis from Infectious Lymphocytic Encephalitis by Analysing the Lymphocyte Subsets of Cerebrospinal Fluid.

Anal Cell Pathol (Amst) 2019 3;2019:9684175. Epub 2019 Dec 3.

Department of Neurology, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, 210029 Nanjing, China.

This study is aimed at investigating the lymphocyte subsets of cerebrospinal fluid (CSF) to provide possible differential diagnostic values and better understand the pathophysiological mechanism underlying autoimmune encephalitis (AE) and infectious lymphocytic encephalitis. A series of CD markers, including CD3/4/8/20 representing different types and developmental stages of lymphocytes, were used to count the corresponding subpopulations of CSF from clinical and laboratory confirmed cases of anti-N-methyl-D-aspartate receptor AE (NMDAR-AE), herpes simplex virus encephalitis (HSVE), and tuberculous meningitis (TBM). The percentages of lymphocytes observed and the CD4 : CD8 ratios were compared between the three groups. Read More

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http://dx.doi.org/10.1155/2019/9684175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914943PMC

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma.

Anal Cell Pathol (Amst) 2019 26;2019:9423907. Epub 2019 Nov 26.

Immunology Department, Victor Babes National Institute of Pathology, Bucharest 050096, Romania.

The epithelial-mesenchymal transition (EMT) is a transformation process mandatory for the local and distant progression of many malignant tumors, including hepatocellular carcinoma (HCC). Matrix metalloproteinases (MMPs) play significant roles in cellular regeneration, programmed death, angiogenesis, and many other essential tissular functions, involved in the normal development and also in pathological processes, such as the EMT. This paper reviews the roles of MMPs in the EMT involved in HCC invasion, as well as the ancillary roles that MMP cross-activation and tissue inhibitors play in modulating this process. Read More

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http://dx.doi.org/10.1155/2019/9423907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899323PMC

Identification and Verification of the Main Differentially Expressed Proteins in Gastric Cancer via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry.

Anal Cell Pathol (Amst) 2019 1;2019:5310684. Epub 2019 Dec 1.

Department of Military Medical and Health Care, Characteristic Medical Center of Chinese People's Armed Police Forces, Tianjin 300162, China.

Background: To find the potential intersections between the differentially expressed proteins and abnormally expressed genes in gastric cancer (GC) patients.

Methods: Gastric cancer tissue and adjacent normal mucosa tissue were used for iTRAQ analysis. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and protein-protein interaction (PPI) analysis were used to evaluate gene function. Read More

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http://dx.doi.org/10.1155/2019/5310684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914953PMC

Clinical Characteristics and Outcomes of Acute Lung Injury Caused by Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Retrospective Cohort Study from a Single Institution in China.

Anal Cell Pathol (Amst) 2019 26;2019:4307651. Epub 2019 Nov 26.

Department of Respiratory Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Background: Acute lung injury (ALI) is a rare but life-threatening pulmonary complication of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). The aim of this study was to characterize the common risk factors, clinical features, imaging findings, treatments, and outcomes of acute lung injury caused by TACE.

Methods: A retrospective study was performed on all TACE-associated ALI cases that were diagnosed at authors' hospital from January 2015 to June 2018. Read More

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http://dx.doi.org/10.1155/2019/4307651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899281PMC

Kaempferol Promotes Apoptosis While Inhibiting Cell Proliferation via Androgen-Dependent Pathway and Suppressing Vasculogenic Mimicry and Invasion in Prostate Cancer.

Anal Cell Pathol (Amst) 2019 1;2019:1907698. Epub 2019 Dec 1.

Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Kaempferol is a well-known natural flavonol reported to be a potential treatment for multiple cancers. In this study, we demonstrated that cell growth of androgen-sensitive LNCaP cells could be inhibited 33% by 5 M kaempferol, around 60% by 10 M kaempferol, and almost 100% by 15 M kaempferol. Also, kaempferol showed relatively limited effect on PC-3 cells and nonmalignant RWPE-1 cells. Read More

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http://dx.doi.org/10.1155/2019/1907698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913338PMC

A Circulating miRNA-Based Scoring System Established by WGCNA to Predict Colon Cancer.

Anal Cell Pathol (Amst) 2019 1;2019:1571045. Epub 2019 Dec 1.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China.

Introduction: Circulation microRNAs (miRNAs) perform as potential diagnostic biomarkers of many kinds of cancers. This study is aimed at identifying circulation miRNAs as diagnostic biomarkers in colon cancer.

Methods: We conducted a weighted gene coexpression network analysis (WGCNA) in miRNAs to find out the expression pattern among circulation miRNAs by using a "WGCNA" package in R. Read More

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http://dx.doi.org/10.1155/2019/1571045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913280PMC

SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation.

Anal Cell Pathol (Amst) 2019 13;2019:3013765. Epub 2019 Nov 13.

Department of Pulmonary and Critical Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Inflammation plays a pivotal role in the development of pulmonary arterial hypertension (PAH). Meanwhile, serum glucocorticoid-regulated kinase-1 (SGK1) has been considered to be an important factor in the regulation of inflammation in some vascular disease. However, the role of SGK1 in hypoxia-induced inflammation and PAH is still unknown. Read More

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http://dx.doi.org/10.1155/2019/3013765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877960PMC

Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats.

Anal Cell Pathol (Amst) 2019 22;2019:9895485. Epub 2019 Oct 22.

Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

Natural oils are traditional medicinal herbs, which have attracted interests for its potential anti-inflammatory and anticancer activities. The present work is aimed at evaluating the protective effect of garlic oil and cinnamon oil on diethylnitrosamine- (DENA-) and 2-acetylaminofluorene- (2-AAF-) induced p53 gene mutation and hepatocarcinogenesis in rats. Forty male albino rats were divided into 4 equal groups: control, hepatocellular carcinoma (HCC), garlic oil-HCC, and cinnamon oil-HCC. Read More

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http://dx.doi.org/10.1155/2019/9895485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855081PMC

In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers.

Anal Cell Pathol (Amst) 2019 4;2019:7653230. Epub 2019 Nov 4.

Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China.

Liver metastasis is the most common form of metastatic colorectal cancers during the course of the disease. The global change in protein abundance in liver metastatic colorectal cancers and its role in metastasis establishment have not been comprehensively analyzed. In the present study, fresh-frozen tissue samples including normal colon/localized/liver metastatic CRCs from each recruited patient were analyzed by quantitative proteomics using a multiplexed TMT labeling strategy. Read More

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http://dx.doi.org/10.1155/2019/7653230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875276PMC
May 2020
1.758 Impact Factor

Proteomic Technology "Lens" for Epithelial-Mesenchymal Transition Process Identification in Oncology.

Anal Cell Pathol (Amst) 2019 29;2019:3565970. Epub 2019 Oct 29.

Faculty of Biology, University of Bucharest, Bucharest 76201, Romania.

The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours. Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years. Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets. Read More

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http://dx.doi.org/10.1155/2019/3565970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855076PMC

miR-590-3p and Its Downstream Target Genes in HCC Cell Lines.

Anal Cell Pathol (Amst) 2019 3;2019:3234812. Epub 2019 Nov 3.

Biotechnology Program, The American University in Cairo, Cairo, Egypt.

miRNAs are small non-coding RNA sequences of 18-25 nucleotides. They can regulate different cellular pathways by acting on tumor suppressors, oncogenes, or both. miRNAs are mostly tissue-specific, and their expression varies depending on the cancer or the tissue in which they are found. Read More

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http://dx.doi.org/10.1155/2019/3234812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875279PMC

Immunohistochemical Study Using Monoclonal VE1 Antibody Can Substitute the Molecular Tests for Apprehension of BRAF V600E Mutation in Patients with Non-small-Cell Lung Carcinoma.

Anal Cell Pathol (Amst) 2019 5;2019:2315673. Epub 2019 Nov 5.

Basic Science Dept. College of Dentistry, Babylon University, Iraq.

In patients with non-small-cell lung carcinoma (NSCLC), the analysis of BRAF V600E mutation has become more and more applied since the introduction of many mutation-targeted medications. In this regard, the advantage of immunohistochemistry (IHC) as a reliable diagnostic test substitute to other molecular studies has not been approved yet. To examine the dependability of using immunohistochemical method utilizing monoclonal VE1 antibody in the detection of BRAF V600 E mutation in patients with non-small-cell lung carcinoma and compare the results there with that of polymerase chain reaction (SSCP-PCR). Read More

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http://dx.doi.org/10.1155/2019/2315673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874948PMC

Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Anal Cell Pathol (Amst) 2019 14;2019:5189165. Epub 2019 Oct 14.

Department of Respiratory Medicine, The Huaian Clinical College of Xuzhou Medical University, Huaian 223001, China.

Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Read More

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http://dx.doi.org/10.1155/2019/5189165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815641PMC

The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related Aging Process: An Experimental Study.

Anal Cell Pathol (Amst) 2019 8;2019:3563215. Epub 2019 Oct 8.

Balikesir University, Faculty of Medicine Department of Physiology, Balikesir, Turkey.

Objective: To evaluate the effect of streptozotocin-induced experimental diabetes mellitus on p16, p53, Ki67, and Bcl2 expressions and histopathological changes in the tongue of the rats.

Material And Methods: Twenty-two adult female Sprague-Dawley rats were used. The rats were randomly divided into 2 groups ( = 14) as control (C) ( = 8) and diabetic (DM) ( = 6). Read More

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http://dx.doi.org/10.1155/2019/3563215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800967PMC

The State of the Art on Blood MicroRNAs in Pancreatic Ductal Adenocarcinoma.

Anal Cell Pathol (Amst) 2019 10;2019:9419072. Epub 2019 Sep 10.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Despite enormous advances being made in diagnosis and therapeutic interventions, pancreatic ductal adenocarcinoma (PDAC) is still recognized as one of the most lethal malignancies. Early diagnosis and timely curative surgery can markedly improve the prognosis; hence, there is an unmet necessity to explore efficient biomarkers for patients' benefit. Recently, blood miRNAs (miRNAs) have been reported to be a novel biomarker in human cancers. Read More

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https://www.hindawi.com/journals/acp/2019/9419072/
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http://dx.doi.org/10.1155/2019/9419072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754866PMC
April 2020
4 Reads

The Combination Strategy of Transarterial Chemoembolization and Radiofrequency Ablation or Microwave Ablation against Hepatocellular Carcinoma.

Anal Cell Pathol (Amst) 2019 26;2019:8619096. Epub 2019 Aug 26.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery First Affiliated Hospital, School of Medicine, Zhejiang University, NHFPC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou 310003, China.

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Hepatectomy and liver transplantation (LT) are regarded as the radical treatment, but great majority of patients are already in advanced stage on the first diagnosis and lose the surgery opportunity. Multifarious image-guided interventional therapies, termed as locoregional ablations, are recommended by various HCC guidelines for the clinical practice. Read More

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http://dx.doi.org/10.1155/2019/8619096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732647PMC
April 2020
15 Reads
1.758 Impact Factor

Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis.

Anal Cell Pathol (Amst) 2019 26;2019:3815786. Epub 2019 Aug 26.

The Department of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250014 Shandong Province, China.

Aim: Microvessel density is a marker of tumor angiogenesis activity for development and metastasis. Our preliminary study showed that ginsenoside Rg3 (Rg3) induces apoptosis in hepatocellular carcinoma (HCC) . The aim of this study was to investigate the cross-link for apoptosis induction and antiangiogenesis effect of Rg3 on orthotopic HCC . Read More

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http://dx.doi.org/10.1155/2019/3815786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732603PMC
April 2020
1 Read

Localized Amyloidosis of the Upper Aerodigestive Tract: Complex Analysis of the Cellular Infiltrate and the Amyloid Mass.

Anal Cell Pathol (Amst) 2019 19;2019:6165140. Epub 2019 Aug 19.

Department of Pathology, Oral Pathology Unit, Medical School and Clinical Center, Pécs University, Hungary.

Objectives: The aim of this study was to analyse the composition of amyloid mass and the plasmacytic infiltrate of localized amyloidosis of the upper aerodigestive tract.

Methods: Biopsy materials were studied by light microscopy, immunohistochemistry (IHC), and mRNA in situ hybridization (mRNA-ISH). The amyloid mass was also analysed with high-performance liquid chromatography mass spectrometry- (HPLC-MS-) based proteomics. Read More

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http://dx.doi.org/10.1155/2019/6165140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721467PMC

Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line.

Anal Cell Pathol (Amst) 2019 4;2019:1598182. Epub 2019 Aug 4.

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Human hepatocellular carcinoma (HCC) is the most common and recurrent type of primary adult liver cancer without any effective therapy. Plant-derived compounds acting as anticancer agents can induce apoptosis by targeting several signaling pathways. Strigolactone (SL) is a novel class of phytohormone, whose analogues have been reported to possess anticancer properties on a panel of human cancer cell lines through inducing cell cycle arrest, destabilizing microtubular integrity, reducing damaged in the DNA repair machinery, and inducing apoptosis. Read More

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http://dx.doi.org/10.1155/2019/1598182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701435PMC
April 2020
1 Read
1.758 Impact Factor

Dynamics of the Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis.

Anal Cell Pathol (Amst) 2019 24;2019:8079368. Epub 2019 Jul 24.

Sechenov University, Moscow, Russia.

Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation of neoplasms (>120 days) and after the development of tumours of various histogeneses (liver, pancreas, and stomach) (>240 days). Egg production was observed to increase with the decrease in the number of parasites in the liver. Read More

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http://dx.doi.org/10.1155/2019/8079368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681594PMC

CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells.

Anal Cell Pathol (Amst) 2019 24;2019:7405602. Epub 2019 Jul 24.

Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Aims: Inflammation was closely associated with diabetes-related endothelial dysfunction. C1q/tumor necrosis factor-related protein 3 (CTRP3) is a member of the CTRP family and can provide cardioprotection in many cardiovascular diseases via suppressing the production of inflammatory factors. However, the role of CTRP3 in high glucose- (HG-) related endothelial dysfunction remains unclear. Read More

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http://dx.doi.org/10.1155/2019/7405602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681575PMC

Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway.

Anal Cell Pathol (Amst) 2019 8;2019:9627810. Epub 2019 Jul 8.

Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF-B survival pathways. Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. In some cases, cisplatin+AG-treated cells were pre-incubated either with [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, or with LY294002, a PI3K inhibitor. Read More

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http://dx.doi.org/10.1155/2019/9627810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644235PMC
April 2020
1 Read

Current Research Progress on Long Noncoding RNAs Associated with Hepatocellular Carcinoma.

Anal Cell Pathol (Amst) 2019 24;2019:1534607. Epub 2019 Jun 24.

Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medicine, Jiamusi, Heilongjiang 154007, China.

Hepatocellular carcinoma (HCC) is the second leading cause of mortality among cancers. It has been found that long noncoding RNAs (lncRNAs) are involved in many human cancers, including liver cancer. It has been identified that carcinogenic and tumor-suppressing lncRNAs are associated with complex processes in liver cancer. Read More

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http://dx.doi.org/10.1155/2019/1534607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612982PMC
December 2019
3 Reads

Recombinant -Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5.

Anal Cell Pathol (Amst) 2019 11;2019:5853426. Epub 2019 Jun 11.

The Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Background And Aims: Klotho is an aging-suppressor gene mainly expressed in the renal tubules. The klotho gene encodes the -klotho protein, which has many functions. Previous studies have found that -klotho protein has a cardiorenal protective function. Read More

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http://dx.doi.org/10.1155/2019/5853426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594328PMC
December 2019
12 Reads

Destruction of the Dorsal Motor Nucleus of the Vagus Aggravates Inflammation and Injury from Acid-Induced Acute Esophagitis in a Rat Model.

Anal Cell Pathol (Amst) 2019 4;2019:8243813. Epub 2019 Jun 4.

Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Beijing, China.

Background/aims: The aim of this study is to examine the protective effect of the cholinergic anti-inflammatory pathway (CAP) in experimental esophagitis in rats.

Methods: A total of 40 male Sprague-Dawley (SD) rats were randomly divided into five groups as follows: control group, sham + saline group, sham + acid group, operation + saline group, and operation + acid group. Two weeks after the dorsal motor nucleus of the vagus (DMV) destruction, hydrochloric acid with pepsin was perfused into the lower part of the esophagus for 90 min. Read More

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http://dx.doi.org/10.1155/2019/8243813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589286PMC
December 2019
6 Reads