Search our Database of Scientific Publications and Authors

I’m looking for a

    10049 results match your criteria Cellular Immunology [Journal]

    1 OF 201

    Niche signals and transcription factors involved in tissue-resident macrophage development.
    Cell Immunol 2018 Feb 13. Epub 2018 Feb 13.
    Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Technologiepark 927, 9052 Gent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Gent, Belgium. Electronic address:
    Tissue-resident macrophages form an essential part of the first line of defense in all tissues of the body. Next to their immunological role, they play an important role in maintaining tissue homeostasis. Recently, it was shown that they are primarily of embryonic origin. Read More

    The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity.
    Cell Immunol 2018 Feb 8. Epub 2018 Feb 8.
    Laboratory of Cellular and Molecular Immunology, GIGA-Research, Liege University, 4000 Liege, Belgium. Electronic address:
    Lung macrophages have mostly been studied considering only their most accessible and well-defined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of their tissue counterpart, the interstitial macrophage (IM), have long remained much more elusive. Yet, recent evidence supports the notion that IMs perform important immune functions in the lung, notably in terms of innate immunoregulation. Read More

    FOXP3 renders activated human regulatory T cells resistant to restimulation-induced cell death by suppressing SAP expression.
    Cell Immunol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address:
    Restimulation-induced cell death (RICD) is an apoptotic program that regulates effector T cell expansion, triggered by repeated stimulation through the T cell receptor (TCR) in the presence of interleukin-2 (IL-2). Although CD4regulatory T cells (Tregs) consume IL-2 and experience frequent TCR stimulation, they are highly resistant to RICD. Resistance in Tregs is dependent on the forkhead box P3 (FOXP3) transcription factor, although the mechanism remains unclear. Read More

    Dynamic plasticity of macrophage functions in diseased liver.
    Cell Immunol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Medicine III, University Hospital Aachen, Aachen, Germany. Electronic address:
    Liver macrophages attract increasing interest due to their crucial roles in homeostasis and hepatic diseases. Recent findings in mice and man suggest a remarkable phenotypic and functional diversity of liver macrophages. Kupffer cells, the subset of tissue resident macrophages with sentinel functions in liver, mainly arise from embryogenic precursors, whereas in injury, liver tissue is engrafted by monocyte-derived macrophages. Read More

    Alteration of CCR6CD95CD4naïve T cells in HIV-1 infected patients: Implication for clinical practice.
    Cell Immunol 2018 Feb 10. Epub 2018 Feb 10.
    Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang 110001, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou 310003, China. Electronic address:
    The profound deficiency of Th17 cells contributes to HIV disease progression. The mechanisms of their perturbation remain unclear. Recently, CCR6CD95CD4naïve T cells (CCR6CD95CD4T), identified as pre-committed Th17 precursors, were recognized as a subpopulation of CD4T cells with stem cell properties. Read More

    Characterization of CD4T cell-mediated cytotoxicity in patients with multiple myeloma.
    Cell Immunol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China. Electronic address:
    Multiple myeloma (MM) is an incurable cancer characterized by the development of malignant plasma cells. The CD8 T cell-mediated cytotoxicity is considered a major player in antitumor immunity, but in MM patients, the CD8 T cells displayed senescence markers and were functionally impaired. To investigate whether cytotoxic CD4 T cells could act as a treatment alternative in MM, we examined the frequency and function of naturally occurring cytotoxic CD4 T cells in MM patients. Read More

    The combination of maltose-binding protein and BCG-induced Th1 activation is involved in TLR2/9-mediated upregulation of MyD88-TRAF6 and TLR4-mediated downregulation of TRIF-TRAF3.
    Cell Immunol 2018 Mar 12;325:56-63. Epub 2018 Feb 12.
    Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun, China. Electronic address:
    Our previous study demonstrated that maltose-binding protein (MBP) activated Th1 through the TLR2-mediated MyD88-dependent pathway and the TLR4-mediated TRIF-dependent pathway. The combination of MBP and BCG synergistically induced Th1 activation, and the TLR2/9-mediated MyD88-dependent pathway is involved in this process. To further explore this mechanism, we stimulated purified mouse CD4T cells with MBP and BCG in vitro. Read More

    CD103CD8T lymphocytes in non-small cell lung cancer are phenotypically and functionally primed to respond to PD-1 blockade.
    Cell Immunol 2018 Mar 7;325:48-55. Epub 2018 Feb 7.
    Department of Thoracic Surgery, Tong Ji Medical School, Huazhong University of Science and Technology, China; Laboratory of Thoracic Surgery, Tong Ji Hospital, Tong Ji Medical School, Huazhong University of Science and Technology, China. Electronic address:
    CD103CD8tumor infiltrating lymphocytes (TILs) have been linked to prolonged survival in various types of cancer including non-small cell lung cancer (NSCLC). However, the factors associated with the retention of CD103CD8TILs in lung cancer tissues remain largely unknown. Additionally, the contribution of CD103CD8TILs to effective PD-1 based immunotherapy has not been fully elucidated. Read More

    Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia.
    Cell Immunol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Development and Regeneration, Stem Cell and Developmental Biology, Stem Cell Institute Leuven, KU Leuven, Leuven, Belgium. Electronic address:
    Over the past decades, the importance of the immune system in a broad scope of pathologies, has drawn attention towards tissue-resident macrophages, such as microglia in the brain. To enable the study of for instance microglia, it is crucial to recreate in vitro (and in vivo) assays. However, very fast loss of tissue-specific features of primary tissue resident macrophages, including microglia, upon in vitro culture has complicated such studies. Read More

    Macrophages and lipid metabolism.
    Cell Immunol 2018 Feb 2. Epub 2018 Feb 2.
    Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Technologiepark 927, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address:
    Distinct macrophage populations throughout the body display highly heterogeneous transcriptional and epigenetic programs. Recent research has highlighted that these profiles enable the different macrophage populations to perform distinct functions as required in their tissue of residence, in addition to the prototypical macrophage functions such as in innate immunity. These 'extra' tissue-specific functions have been termed accessory functions. Read More

    Bladder resident macrophages: Mucosal sentinels.
    Cell Immunol 2018 Feb 2. Epub 2018 Feb 2.
    Unit of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris 75015, France; Inserm U1223, Paris 75015, France. Electronic address:
    Macrophages are instrumental in the response to infectious and noninfectious diseases, however, their role in the bladder is poorly understood. Indeed, the bladder is a mucosal tissue frequently overlooked in research, despite the prevalence of illnesses such as urinary tract infection and bladder cancer. Notably, bladder tissue macrophages are among the most populous resident immune cells in this organ and recent studies support that resident macrophages and infiltrating monocytes play nonredundant roles in response to infection, immunotherapy, and inflammation. Read More

    Tissue macrophages as mediators of a healthy relationship with gut commensal microbiota.
    Cell Immunol 2018 Feb 2. Epub 2018 Feb 2.
    Center for Gastrointestinal Biology, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil. Electronic address:
    Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors the largest bacteria diversity within the body and complex mechanisms control microbiota community under homeostasis. Read More

    IFN-γ and tumor gangliosides: Implications for the tumor microenvironment.
    Cell Immunol 2018 Mar 2;325:33-40. Epub 2018 Feb 2.
    Tumor Immunology, Children's Cancer Research Institute, St. Anna Kinderkrebsforschung e.V., Zimmermannplatz 10, Vienna, Austria. Electronic address:
    Gangliosides shed by tumors into their microenvironment (TME) are immunoinhibitory. Interferon-γ (IFN-γ) may boost antitumor immune responses. Thus we wondered whether IFN-γ would counteract tumor ganglioside-mediated immune suppression. Read More

    C5a receptor targeting of partial non-structural protein 3 of dengue virus promotes antigen-specific IFN-γ-producing T-cell responses in a mucosal dengue vaccine model.
    Cell Immunol 2018 Mar 15;325:41-47. Epub 2018 Feb 15.
    Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju 54896, Republic of Korea; Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 54896, Republic of Korea. Electronic address:
    Mucosal vaccination is an ideal strategy to induce protective immunity in both mucosal and parenteral areas. Successful induction of an antigen-specific immune response via mucosal administration essentially requires the effective delivery of antigen into a mucosal immune inductive site, which depends on antigen delivery into M cells. We previously reported that M cells specifically express C5aR, and antigen targeting to C5aR by using specific ligands, including Co1 peptide, promotes the antigen-specific immune response in both mucosal and systemic immune compartments. Read More

    MIF promotes a differential Th1/Th2/Th17 inflammatory response in human primary cell cultures: Predominance of Th17 cytokine profile in PBMC from healthy subjects and increase of IL-6 and TNF-α in PBMC from active SLE patients.
    Cell Immunol 2018 Feb 26;324:42-49. Epub 2017 Dec 26.
    Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. Electronic address:
    Macrophage migration Inhibitory Factor (MIF) is a cytokine associated with the pathogenesis of autoimmune inflammatory diseases. There is evidence that MIF functions in a positive-feedback-loop with proinflammatory cytokines and could perpetuate the inflammatory process in Systemic Lupus Erythematosus (SLE).The aim of this study was to assess the effect of recombinant-human-MIF (rhMIF) on the expression of Th1, Th2 and Th17 cytokines in Peripheral Blood Mononuclear Cells (PBMC) from Healthy Subjects (HS) and SLE patients. Read More

    Lymph node macrophages: Scavengers, immune sentinels and trophic effectors.
    Cell Immunol 2018 Feb 1. Epub 2018 Feb 1.
    Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France. Electronic address:
    Lymph nodes (LN) are secondary lymphoid organs dispersed throughout the body that filter lymph and assist the immune system in mounting immune responses. These functions are supported by a complex stromal microarchitecture composed of mesenchymal and vascular elements. Different subsets of macrophages (MΦ) reside in the LN and are endowed with immune and trophic functions. Read More

    Cancer-associated fibroblasts in tumor microenvironment - Accomplices in tumor malignancy.
    Cell Immunol 2018 Jan 31. Epub 2018 Jan 31.
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore; Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore; KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore. Electronic address:
    There is much cellular heterogeneity in the tumor microenvironment. The tumor epithelia and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of cancer development and progression. Despite this, many anticancer therapies are designed around druggable features of tumor epithelia, ignoring the supportive role of stromal cells. Read More

    The biology of serous cavity macrophages.
    Cell Immunol 2018 Jan 9. Epub 2018 Jan 9.
    The University of Edinburgh/MRC Centre for Inflammation Research, University of Edinburgh, UK. Electronic address:
    For decades, it has been known that the serous cavities, which include the peritoneal, pleural and pericardial cavities, harbour large numbers of macrophages. In particular, due to the ease of isolating these cells, the peritoneal cavity has been used as a convenient source of macrophages to examine many facets of macrophage biology over the last 50-60 years. Despite this, it is only recently that the true heterogeneity of serous cavity mononuclear phagocyte compartment, which includes macrophages and dendritic cells, has been revealed. Read More

    Some news from the unknown soldier, the Peyer's patch macrophage.
    Cell Immunol 2018 Jan 31. Epub 2018 Jan 31.
    Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France. Electronic address:
    In mammals, macrophages (MF) are present in virtually all tissues where they serve many different functions linked primarily to the maintenance of homeostasis, innate defense against pathogens, tissue repair and metabolism. Although some of these functions appear common to all tissues, others are specific to the homing tissue. Thus, MF become adapted to perform particular functions in a given tissue. Read More

    Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?
    Cell Immunol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy. Electronic address:
    In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in different clinical studies. Currently, immunotherapy was clinically validated as effective treatment option for many tumors such as melanoma, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC). Some surface receptors of immune cells, called immune checkpoint receptors, may inhibit activity of proinflammatory lymphocytes, following binding with specific ligands. Read More

    Metabolic regulation of macrophages in tissues.
    Cell Immunol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands; Department of Medical Biochemistry, Academic Medical Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
    Macrophages are innate immune cells that provide host defense and have tissue-specific roles in the maintenance of organ homeostasis and integrity. In most cases macrophages keep us healthy but when their balanced response to damage or homeostatic signals is perturbed, they can drive chronic inflammatory responses and pathology. To fulfil their broad range of functions, macrophages adopt a plethora of activation states. Read More

    Oxidation of factor VIII increases its immunogenicity in mice with severe hemophilia A.
    Cell Immunol 2018 Mar 31;325:64-68. Epub 2018 Jan 31.
    INSERM, UMR S 1138, Centre de recherche des Cordeliers, Paris F-75006, France; Université Pierre et Marie Curie-Paris6, UMR S 1138, Centre de recherche des Cordeliers, Paris F-75006, France; Université Paris Descartes, UMR S 1138, Centre de recherche des Cordeliers, Paris F-75006, France. Electronic address:
    The development of antibodies against therapeutic factor VIII (FVIII) represents the major complication of replacement therapy in patients with severe hemophilia A. Amongst the environmental risk factors that influence the anti-FVIII immune response, the presence of active bleeding or hemarthrosis has been evoked. Endothelium damage is typically associated with the release of oxidative compounds. Read More

    Alveolar Macrophages.
    Cell Immunol 2018 Jan 20. Epub 2018 Jan 20.
    Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA. Electronic address:
    Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. Read More

    Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.
    Cell Immunol 2018 Mar 16;325:14-22. Epub 2018 Jan 16.
    Division of Microbiology and Infection Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Research Centre for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:
    Streptococcus pneumoniae is a leading cause of bacterial pneumonia. Our previous study suggested that S. pneumoniae autolysis-dependently releases intracellular pneumolysin, which subsequently leads to lung injury. Read More

    Recent advances in the understanding of microglial development and homeostasis.
    Cell Immunol 2018 Jan 10. Epub 2018 Jan 10.
    Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address:
    Microglia are the resident macrophages of the central nervous system (CNS). These pivotal cells arise early during embryonic development and provide both developmental support and immune protection to the brain. In adults, microglia contribute to brain homeostasis and mediate an intriguing interplay between the CNS and the gut microbiota. Read More

    Direct anti-inflammatory effects of granulocyte colony-stimulating factor (G-CSF) on activation and functional properties of human T cell subpopulations in vitro.
    Cell Immunol 2018 Mar 19;325:23-32. Epub 2018 Jan 19.
    Immanuel Kant Baltic Federal University, 14 A. Nevskogo St., Kaliningrad 236016, Russia. Electronic address:
    We investigated the direct effects of human granulocyte colony-stimulating factor (G-CSF) on functionality of human T-cell subsets. CD3T-lymphocytes were isolated from blood of healthy donors by positive magnetic separation. T cell activation with particles conjugated with antibodies (Abs) to human CD3, CD28 and CD2 molecules increased the proportion of cells expressing G-CSF receptor (G-CSFR, CD114) in all T cell subpopulations studied (CD45RA/CD197naive T cells, CD45RA/CD197central memory T cells, CD45RA/CD197effector memory T cells and CD45RA/CD197terminally differentiated effector T cells). Read More

    Role of the IL-33/ST2L axis in colorectal cancer progression.
    Cell Immunol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Life Science, Shimane University Faculty of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan. Electronic address:
    Interleukin-33 (IL-33) has been identified as a natural ligand of ST2L. IL-33 primarily acts as a key regulator of Th2 responses through binding to ST2L, which is antagonized by soluble ST2 (sST2). The IL-33/ST2L axis is involved in various inflammatory pathologies, including ulcerative colitis (UC). Read More

    Transcriptomic evidence of immune activation in macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis.
    Cell Immunol 2018 Mar 3;325:1-13. Epub 2018 Jan 3.
    University of Maryland School of Medicine, Baltimore, MD, USA; Veterans Administration Medical Center, Baltimore, MD, USA. Electronic address:
    Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease manifested by overtly scarred peripheral and basilar regions and more normal-appearing central lung areas. Lung tissues from macroscopically normal-appearing (IPFn) and scarred (IPFs) areas of explanted IPF lungs were analyzed by RNASeq and compared with healthy control (HC) lung tissues. There were profound transcriptomic changes in IPFn compared with HC tissues, which included elevated expression of numerous immune-, inflammation-, and extracellular matrix-related mRNAs, and these changes were similar to those observed with IPFs compared to HC. Read More

    Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans.
    Cell Immunol 2018 Feb 28;324:59-73. Epub 2017 Dec 28.
    Division of Molecular Immunology & Microbiology (MIM), National Institute for Research in Reproductive Health (NIRRH), J.M. Street, Parel, Mumbai 400012, India. Electronic address:
    The female reproductive tract (FRT) presents a unique challenge to the mucosal immune system as it needs to monitor constantly for the presence of opportunistic pathogens amidst its commensal flora. During infection, autophagy plays a critical role in pathogen clearance, presentation of antigens and production of pro-inflammatory cytokines. However, no information is available that describes the role of autophagy in mouse vaginal infection of Candida albicans. Read More

    High macrophage PD-L1 expression not responsible for T cell suppression.
    Cell Immunol 2018 Feb 30;324:50-58. Epub 2017 Dec 30.
    Department of Biology, Rider University, Lawrenceville, NJ, 08648, USA. Electronic address:
    Tumors are often comprised of microenvironments (TMEs) with a high proportion of cells and molecules that regulate immunity. Peritoneal cavity (PerC) cell culture reproduces key features of TMEs as lymphocyte proliferation is suppressed by PerC macrophages (Mϕs). We monitored the expression of T cell stimulatory (Class II MHC, B7) and inhibitory (PD-L1) molecules by PerC APCs before and after culture and report here that IFNγ-driven PD-L1 expression increased markedly on PerC Mϕs after TCR ligation, even more so than seen with direct APC activation by LPS. Read More

    Immunomodulatory, liver depot gene therapy for Pompe disease.
    Cell Immunol 2017 Dec 29. Epub 2017 Dec 29.
    Division of Medical Genetics, Department of Pediatrics, Duke University Medical School, Durham, NC, USA; Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. Electronic address:
    Pompe disease is caused by mutations in acid alpha glucosidase (GAA) that causes accumulation of lysosomal glycogen affecting the heart and skeletal muscles, and can be fatal. Enzyme replacement therapy (ERT) with recombinant human GAA (rhGAA) improves muscle function by reducing glycogen accumulation. Limitations of ERT include a short half-life and the formation of antibodies that result in reduced efficacy. Read More

    Muscularis macrophages: Key players in intestinal homeostasis and disease.
    Cell Immunol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), Intestinal Neuro-immune Interactions, University of Leuven, Leuven, Belgium. Electronic address:
    Macrophages residing in the muscularis externa of the gastrointestinal tract are highly specialized cells that are essential for tissue homeostasis during steady-state conditions as well as during disease. They are characterized by their unique protective functional phenotype that is undoubtedly a consequence of the reciprocal interaction with their environment, including the enteric nervous system. This muscularis macrophage-neuron interaction dictates intestinal motility and promotes tissue-protection during injury and infection, but can also contribute to tissue damage in gastrointestinal disorders such as post-operative ileus and gastroparesis. Read More

    Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production.
    Cell Immunol 2018 Feb;324:33-41
    Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan. Electronic address:
    Tetraspanin membrane protein, epithelial membrane protein 3 (Emp3), is expressed in lymphoid tissues. Herein, we have examined the Emp3 in antigen presenting cell (APC) function in the CD8cytotoxic T lymphocytes (CTLs) induction. Emp3-overexpressing RAW264. Read More

    The tumor microenvironment: Thousand obstacles for effector T cells.
    Cell Immunol 2017 Dec 8. Epub 2017 Dec 8.
    Institute for Medical Immunology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany. Electronic address:
    The immune system is endowed with the capability to recognize and destroy transformed cells, but even in the presence of an immune infiltrate many tumors do progress. In the last decades new discoveries have shed light into (some of) the underlying mechanisms. Immune effector cells are not only under the influence of immune suppressive cell subsets, but also intrinsically regulated by immune check point molecules that under physiological condition avoid attach of healthy tissue. Read More

    Infection of hematopoietic stem cells by Leishmania infantum increases erythropoiesis and alters the phenotypic and functional profiles of progeny.
    Cell Immunol 2017 Nov 7. Epub 2017 Nov 7.
    Grupo Integrado de Pesquisa em Biomarcadores, Instituto René Rachou, FIOCRUZ, Belo Horizonte, Brazil. Electronic address:
    Immunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the relationship between parasite dynamics in this organ and the function of either hematopoietic stem cells and progenitor cells themselves. Read More

    Influence of membrane cholesterol on monocyte chemotaxis.
    Cell Immunol 2018 Feb 9;324:74-77. Epub 2017 Dec 9.
    Department of Biomedical, Chemical and Materials Engineering, San José State University, San José, CA 95192, USA. Electronic address:
    Cholesterol content influences several important physiological functions due to its effect on membrane receptors. In this work, we tested the hypothesis that cellular cholesterol alters chemotactic response of monocytes to Monocyte Chemoattractant Protein-1 (MCP-1) due to their effect on the receptor, CCR2. We used Methyl-β-cyclodextrin (MβCD) to alter the baseline cholesterol in human monocytic cell line THP-1, and evaluated their chemotactic response to MCP-1. Read More

    Inflammatory cells implicated in neoplasia development in idiopathic inflammatory bowel disease.
    Cell Immunol 2017 Nov 10. Epub 2017 Nov 10.
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:
    The inflammatory mechanisms that lead to the clinical symptoms that are grouped under the term inflammatory bowel disease have not been fully characterized. Although a specific mechanism has not been identified, inflammatory bowel disease is believed to be related to an inability by the immune system to shut active inflammation within the intestine. Many contributing factors have been implicated in the disease process. Read More

    Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response.
    Cell Immunol 2017 Dec 2. Epub 2017 Dec 2.
    University of Rome 'Tor Vergata', Department of Experimental Medicine and Surgery, Building D, Room D26, II Floor, Via Montpellier 1, 00133 Rome, Italy.
    Mesenchymal stem cells (MSCs) exist in almost all tissues with the capability to differentiate into several different cell types and hold great promise in tissue repairs in a cell replacement manner. The study of the bidirectional regulation between MSCs and immune response has ushered an age of rethinking of tissue regeneration in the process of stem cell-based tissue repairs. By sensing damaged signals, both endogenous and exogenous MSCs migrate to the damaged site where they involve in the reconstitution of the immune microenvironment and empower tissue stem/progenitor cells and other resident cells, whereby facilitate tissue repairs. Read More

    High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation.
    Cell Immunol 2017 Sep 14. Epub 2017 Sep 14.
    Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address:
    Human regulatory dendritic cells (DCreg) were generated from CD14 immunobead-purified or elutriated monocytes in the presence of vitamin D3 and IL-10. They exhibited similar, low levels of costimulatory CD80 and CD86, but comparatively high levels of co-inhibitory programed death ligand-1 (PD-L1) and IL-10 production compared to control immature DC (iDC). Following Toll-like receptor 4 ligation, unlike control iDC, DCreg resisted phenotypic and functional maturation and further upregulated PD-L1:CD86 expression. Read More

    The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.
    Cell Immunol 2018 Feb 1;324:14-23. Epub 2017 Dec 1.
    Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, Zealand University Hospital, and Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address:
    An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4CD25CD127T cells, increases the expression of HLA-GCD4and CD8T cells, and decreases the expression of ILT2on CD4T cells in resting PBMCs after six days of co-culture. Expression of HLA-G on JEG-3 cells did not affect regulatory T cell phenotypes, but promoted modulation of pro-inflammatory cytokines IFN-γ, TNF-α and IL-17A. Read More

    Preclinical models to assess the immunogenicity of AAV vectors.
    Cell Immunol 2017 Nov 23. Epub 2017 Nov 23.
    The Wistar Institute, Philadelphia, PA, United States. Electronic address:
    Although gene transfer using adeno-associated virus (AAV) vectors has made tremendous progress in recent years, challenges remain due to vector-specific adaptive immune responses. Specifically, AAV-neutralizing antibodies reduce AAV-transduction rates, while CD8T cells directed to AAV capsid antigens cause rejection of AAV-transduced cells. This has been addressed clinically by excluding humans with pre-existing AAV-neutralizing antibodies from gene transfer trials or by using immunosuppression or reduced doses of vectors expressing improved transgene products to blunt or circumvent destructive T cell responses. Read More

    Ebola virus secreted glycoprotein decreases the anti-viral immunity of macrophages in early inflammatory responses.
    Cell Immunol 2018 Feb 27;324:24-32. Epub 2017 Nov 27.
    Division of Biomedical Sciences, Magnolia Research Center, Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine - Carolinas Campus, Spartanburg, SC 29303, United States. Electronic address:
    During Ebola virus (EBOV) infection, secreted glycoprotein (sGP) is found in large quantities in the serum of both patients and infected animal models. It is thought to serve as a decoy for anti-EBOV antibodies. Using an in vitro model incorporating treatment of non-infected human THP-1 macrophages with recombinant EBOV sGP, this study sought to examine the impact of sGP upon key macrophage functions. Read More

    Th17 pathway in recent-onset autoimmune diabetes.
    Cell Immunol 2018 Feb 15;324:8-13. Epub 2017 Nov 15.
    Laboratório de Carboidratos e Radioimunoensaio (LIM 18), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av Dr Arnaldo 455, São Paulo 01246903, Brazil. Electronic address:
    Aims: Evaluate the participation of IL-17 pathway in T1D pathogenesis. T helper 17 cells are potent, highly inflammatory cells that produce interleukin 17A (IL-17A), considered a mediator of various immune disorders. However, their role in Type 1 diabetes (T1D) pathogenesis in humans is not totally elucidated. Read More

    Correlation of graft immune composition with outcomes after allogeneic stem cell transplantation: Moving towards a perfect transplant.
    Cell Immunol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Hematology, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address:
    Allogeneic stem cell transplantation (allo-SCT) offers an important curative therapy for hematological malignancies and other diseases. A number of studies have demonstrated the association of immune compositions in allografts with outcomes after allo-SCT, which promote graft engineering to improve transplant prognosis. This review summarizes the advances in investigating the correlation of the graft immune compositions with transplant outcomes in different transplant modalities, focusing on the immune subsets likely to have the greatest impact on clinical outcomes. Read More

    The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis.
    Cell Immunol 2018 Feb 7;324:1-7. Epub 2017 Nov 7.
    Houston Methodist Research Institute, Houston, TX, USA; Houston Methodist Hospital, Department of Surgery, Houston, TX, USA; University of Texas, MD Anderson Cancer Center, Department of Genetics, Houston, TX, USA. Electronic address:
    Different macrophage subtypes have different morphologies/shapes and functions. Naïve M0 macrophages are elongated. Pro-inflammatory M1 that produce the bactericidal molecule iNos are round. Read More

    Targeting myeloid cells in the tumor sustaining microenvironment.
    Cell Immunol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Dermatology, University Medical Center, Mainz, Germany.
    Myeloid cells are the most abundant cells in the tumor microenvironment (TME). The tumor recruits and modulates endogenous myeloid cells to tumor-associated macrophages (TAM), dendritic cells (DC), myeloid-derived suppressor cells (MDSC) and neutrophils (TAN), to sustain an immunosuppressive environment. Pathologically overexpressed mediators produced by cancer cells like granulocyte-macrophage colony-stimulating- and vascular endothelial growth factor induce myelopoiesis in the bone marrow. Read More

    Recombinant prohibitin protein of Leishmania infantum acts as a vaccine candidate and diagnostic marker against visceral leishmaniasis.
    Cell Immunol 2017 Nov 9. Epub 2017 Nov 9.
    Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
    Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania infantum is one of main disease causative agents in the Americas. In a previous immunoproteomic study, the prohibitin (PHB) protein was identified in L. infantum promastigote and amastigote extracts by antibodies in asymptomatic and symptomatic VL dog sera. Read More

    The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma.
    Cell Immunol 2017 Nov 2. Epub 2017 Nov 2.
    Institut de Cancérologie de l'Ouest, site René Gauducheau, INSERM, UMR1232, Boulevard Professeur Jacques Monod, 44805 Saint-Herblain, France; University of Sheffield, Department of Oncology and Metabolism, INSERM, European Associated Laboratory "Sarcoma Research Unit", Medical School, Beech Hill Road, S10 2RX, Sheffield, UK; University of Nantes, Faculty of Medicine, 44035 Nantes, France. Electronic address:
    Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing calcified osteoid extracellular matrix and inducing lung metastases with a high frequency. The local microenvironment defined several tumor niches controlling the tumor growth and cell extravasation. The immune infiltrate composes one of these niches. Read More

    Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool.
    Cell Immunol 2017 Dec 16;322:74-83. Epub 2017 Oct 16.
    Department of Gastroenterology and Hepatology, Ghent University, Belgium.
    Kupffer cells (KCs) and monocyte-derived macrophages are implicated in non-alcoholic steatohepatitis (NASH) pathogenesis but their functions remain unclear due to the lack of specific markers to distinguish between the different cell types. Additionally, it is unclear if multiple subsets of KCs are present during NASH. Here, we characterized the liver macrophage subsets during methionine/choline deficient (MCD) diet-induced NASH and recovery. Read More

    1 OF 201