10,202 results match your criteria Cellular Immunology [Journal]


Intravital imaging of skin infections.

Authors:
Ali Zaid

Cell Immunol 2019 Apr 1. Epub 2019 Apr 1.

Institute for Glycomics, Griffith University Gold Coast Campus, Parklands Drive, Southport, QLD 4215, Australia.

Intravital imaging of cutaneous immune responses has revealed intricate links between the skin's structural properties, the immune cells that reside therein, and the carefully orchestrated migratory dynamics that enable rapid sensing and subsequent elimination of skin pathogens. In particular, the development of 2-photon intravital microscopy (2P-IVM), which enables the excitation of fluorescent molecules within deep tissue with minimal light scattering and tissue damage, has proven an invaluable tool in the characterization of different cell subset's roles in skin infection. The ability to visualize cells, tissue structures, pathogens and track migratory dynamics at designated times following infection, or during inflammatory responses has been crucial in defining how immune responses in the skin are coordinated, either locally or in concert with circulating immune cells. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.04.001DOI Listing

Wiskott-Aldrich syndrome protein may be critical for CD8 T cell function following MCMV infection.

Cell Immunol 2019 Apr 27;338:43-50. Epub 2019 Mar 27.

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Wiskott-Aldrich syndrome (WAS) patients are characterized by immunodeficiency and viral infections. T cells derived from WAS patients and WAS protein (WASP)-deficient mice have various defects. However, whether WASP plays a role in immune control of cytomegalovirus (CMV) infection remains unclear. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.03.004DOI Listing

T-memory cells against cancer: Remembering the enemy.

Cell Immunol 2019 Apr 16;338:27-31. Epub 2019 Mar 16.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India. Electronic address:

Background: Recently various types of immunotherapies have made immense progress in combating cancer. Adoptive cell therapy, being one of the most favorable forms of immunotherapy, is rapidly moving from bench to bed.

Main Body: Different types of T-memory cells are being used as promising candidates for adoptive cell therapy: T effector memory (T) cells which are terminally differentiated memory cells and attain effector function soon after re-stimulation; T central memory (T) cells which differentiate into effector T-memory subsets and T-effector cells after antigenic stimulation; and tissue T resident memory (T) cells which fight the tumor insult at the peripheral tissues. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.03.002DOI Listing
April 2019
1 Read

Poly(acrylic acid)-Coated Iron Oxide Nanoparticles interact with mononuclear phagocytes and decrease platelet aggregation.

Cell Immunol 2019 Apr 26;338:51-62. Epub 2019 Mar 26.

Grupo de Inmunología Celular e Inmunogenética, Sede de Investigación Universitaria (SIU), Universidad de Antioquia (UDEA), Calle 70 No. 52-21, Medellín, Colombia; Unidad de Citometría de Flujo, Sede de Investigación Universitaria (SIU), Universidad de Antioquia (UDEA), Colombia. Electronic address:

Poly(acrylic acid)-Coated Iron Oxide Nanoparticles (PAC-IONs) did not compromise the viability of mononuclear cells and potentially interact with cells through scavenger receptors. This study evaluated: 1) The capacity of the PAC-IONs to induce platelet activation and aggregation, and 2) The effect of the PAC-IONs in two functions of Monocyte-Derived Macrophages (MDMs) when differentiated in their presence; that is, the removal of apoptotic cells (ACs) and the levels of cytokines induced by Lipopolysaccharide (LPS) and the ACs. The PAC-IONs did not affect the platelet activation but antagonized their aggregation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.03.005DOI Listing

LPS enhances CTB-INSULIN induction of IDO1 and IL-10 synthesis in human dendritic cells.

Cell Immunol 2019 Apr 19;338:32-42. Epub 2019 Mar 19.

Division of Biochemistry, Center for Health Disparity and Molecular Medicine, Loma Linda University, School of Medicine, Loma Linda, CA 92354, United States. Electronic address:

Autoantigen-specific immunotherapy promises effective treatment for devastating tissue specific autoimmune diseases like multiple sclerosis (MS) and type 1 diabetes (T1D). Because activated dendritic cells (DCs) stimulate the differentiation of autoreactive T cells involved in the initiation of autoimmunity, blocking the activation of DCs may be an effective strategy for inhibiting tissue specific autoimmunity. Following this approach, immature DCs were shown to remain inactive after treatment with chimeric fusion proteins composed of the cholera toxin B subunit adjuvant linked to autoantigens like proinsulin (CTB-INS). Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.03.003DOI Listing
April 2019
4 Reads

Burn injury is associated with an infiltration of the wound site with myeloid-derived suppressor cells.

Cell Immunol 2019 Apr 13;338:21-26. Epub 2019 Mar 13.

Department of Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; Coagulation and Blood Research Program, US Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, United States.

Myeloid-derived suppressor cells (MDSCs) have been identified in the burn wound, however their characterization is incomplete. To study this, mice were subjected to a major burn and skin cells were isolated 3 days thereafter for analysis. Significant infiltration of the burn wound with MDSCs was observed as compared with uninjured skin. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.03.001DOI Listing

The TLR7 agonist imiquimod selectively inhibits IL-4-induced IgE production by suppressing IgG1/IgE class switching and germline ε transcription through the induction of BCL6 expression in B cells.

Cell Immunol 2019 Apr 22;338:1-8. Epub 2019 Feb 22.

Department of Microbiology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea; Priority Research Center, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea. Electronic address:

Imiquimod (IMQ) is a selective toll-like receptor 7 (TLR7) agonist. TLR7 activation leads to the production of IFN-γ and pro-inflammatory cytokines by innate immune cells. However, the role of TLR7 in B cells is not fully understood. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.02.006DOI Listing

Emerging roles of and therapeutic strategies targeting BRD4 in cancer.

Cell Immunol 2019 Mar 4;337:48-53. Epub 2019 Feb 4.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and The OSU James Comprehensive Cancer Center, Columbus, OH, United States. Electronic address:

The Bromodomain and Extra-terminal (BET) family of proteins were first recognized as important epigenetic regulators in inflammatory processes; however, there is increasing evidence to support the notion that BET proteins also play a critical role in 'reading' chromatin and recruiting chromatin-regulating enzymes to control gene expression in a number of pathologic processes, including cancer. To this end, the mechanisms by which BET proteins regulate chromatin remodeling and promote tumor-associated inflammation have been heavily studied over the past decade. This article to review the biology of BET protein dysfunction in promoting tumor-associated inflammation and cancer progression and the application of small molecule inhibitors that target specific BET proteins, alone or in combination with immunomodulatory agents as a novel therapeutic strategy for cancer patients. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.02.001DOI Listing
March 2019
4 Reads

E3 ubiquitin ligases in B-cell malignancies.

Cell Immunol 2019 Feb 26. Epub 2019 Feb 26.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Ubiquitylation is a post-translational modification (PTM) that controls various cellular signaling pathways. It is orchestrated by a three-step enzymatic cascade know as the ubiquitin proteasome system (UPS). E3 ligases dictate the specificity to the substrates, primarily leading to proteasome-dependent degradation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.02.004DOI Listing
February 2019

Toll-like receptor 2 deficiency promotes the generation of alloreactive Th17 cells after cardiac transplantation in mice.

Cell Immunol 2019 Apr 22;338:9-20. Epub 2019 Feb 22.

Laboratory of Transplantation, Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

The emergence of alloreactive Th17 cells that mediate allograft rejection has provided an impetus to understand the factors affecting the generation of Th17 cells in allograft transplantation. How toll-like receptor 2 (TLR2) signalling regulates the generation of Th17 cells upon alloantigen stimuli remains unclear. In this study, we used a mouse model of cardiac allograft transplantation to investigate whether TLR2 signalling influences the development of Th17 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183053
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http://dx.doi.org/10.1016/j.cellimm.2019.02.005DOI Listing
April 2019
2 Reads

MiR-129-3p favors intracellular BCG survival in RAW264.7 cells by inhibiting autophagy via Atg4b.

Cell Immunol 2019 Mar 28;337:22-32. Epub 2019 Jan 28.

Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China; Department of Medical Genetic and Cell Biology, College of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China. Electronic address:

Autophagy plays an important role in the fight against Mycobacterium tuberculosis infection. Massive researches proved that miRNAs could be the regulators of autophagy, which implied miRNAs could favor MTB invasion or latent infection. In our study, multiple bioinformatics databases and software were used to seek and lock the miRNAs associating with regulation of autophagy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183045
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http://dx.doi.org/10.1016/j.cellimm.2019.01.004DOI Listing
March 2019
4 Reads

Inclusion of non-target antigen in vaccination favors generation of OVA specific CD4 memory T cells.

Cell Immunol 2019 Mar 19;337:1-14. Epub 2018 Nov 19.

Institute of Science, Nirma University, Ahmedabad, Gujarat, India. Electronic address:

Inducing long-lived memory T cells by sub-unit vaccines has been a challenge. Subunit vaccines containing single immunogenic target antigen from a given pathogen have been designed with the presumption of mimicking the condition associated with natural infection, but fail to induce quality memory responses. In this study, we have included non-target antigens with vaccine candidate, OVA, in the inoculum containing TLR ligands to suffice the minimal condition of pathogen to provoke immune response. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.11.005DOI Listing
March 2019
1 Read

Dendritic cell line AP284 supports Th17 amplification.

Cell Immunol 2019 Mar 10;337:54-61. Epub 2019 Feb 10.

Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235 S/N, Goiânia, Goiás 74605-050, Brazil. Electronic address:

Dendritic cells (DC) have the unique ability to capture microorganisms and activate naive T lymphocytes. Obtaining DC derived from progenitors demands high cost and prolonged cultivation. Different immortalized DC has been isolated but most of them have immature phenotype and depending on growing factors or other stimuli to be used. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.02.003DOI Listing
March 2019
1 Read

Mesenteric lymph node CD4 T lymphocytes migrate to liver and contribute to non-alcoholic fatty liver disease.

Cell Immunol 2019 Mar 28;337:33-41. Epub 2019 Jan 28.

Department of Gastroenterology, Peking University People's Hospital, 100044 Beijing, PR China; Clinical Center of Immune-Mediated Digestive Diseases, Peking University People's Hospital, 100044 Beijing, PR China. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is characterized by altered intestinal microbiota and intestinal immune disorder. Here we investigated the role of mesenteric lymph node (MLN) CD4 T lymphocytes in NAFLD. In high fat diet (HFD)-fed mice, the percentage ratios of Th1 to Th2 cells and Th17 to Treg cells were imbalanced in MLNs. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.01.005DOI Listing
March 2019
1 Read

Immunogenicity and protective potential of Bordetella pertussis biofilm and its associated antigens in a murine model.

Cell Immunol 2019 Mar 30;337:42-47. Epub 2019 Jan 30.

School of Pharmacy and Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia; Department of Microbiology, Pathwest Laboratory Medicine, Fiona Stanley Hospital, Murdoch, Australia. Electronic address:

The resurgence of whooping cough reflects novel genetic variants of Bordetella pertussis and inadequate protection conferred by current acellular vaccines (aP). Biofilm is a source of novel vaccine candidates, including membrane protein assembly factor (BamB) and lipopolysaccharide assembly protein (LptD). Responses of BALB/c mice to candidate vaccines included IFN-γ and IL-17a production by spleen and lymph node cells, and serum IgG1 and IgG2a reactive with whole bacteria or aP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183046
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http://dx.doi.org/10.1016/j.cellimm.2019.01.006DOI Listing
March 2019
5 Reads

Biological activities of interleukin (IL)-21 in human monocytes and macrophages.

Cell Immunol 2019 Mar 8;337:62-70. Epub 2019 Feb 8.

Laboratoire de recherche en inflammation et physiologie des granulocytes, Université du Québec, INRS-Institut Armand-Frappier, Laval, Québec, Canada. Electronic address:

The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.02.002DOI Listing
March 2019
1 Read

IL-17 and limits of success.

Cell Immunol 2018 Sep 17. Epub 2018 Sep 17.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

Interleukin-17 (IL-17) is a potent proinflammatory cytokine that protects a host against fungal and extracellular bacterial infections. On the other hand, excessive or dysregulated production of IL-17 underlines susceptibility to autoimmune disease. Consequently, blocking IL-17 has become an effective strategy for modulating several autoimmune diseases, including multiple sclerosis (MS), psoriasis, and rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.09.001DOI Listing
September 2018
3 Reads
1.924 Impact Factor

Imaging the neutrophil: Intravital microscopy provides a dynamic view of neutrophil functions in host immunity.

Cell Immunol 2019 Jan 23. Epub 2019 Jan 23.

Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address:

Neutrophils are the first cellular responders of the immune system. They employ their impressive arsenal of microbicidal molecules to provide rapid and efficient defense against pathogens. However, the role of neutrophils extends far beyond microbial destruction to include tissue repair and remodeling, provision of signals to the adaptive immune system and body homeostasis. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.01.003DOI Listing
January 2019

The influence of maternal obesity on macrophage subsets in the human decidua.

Cell Immunol 2019 Feb 11;336:75-82. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, University of Groningen and University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. Electronic address:

Obesity is seen as a low grade inflammatory state, and is associated with adverse pregnancy outcomes. Disturbed macrophage characteristics might be essential in obesity associated pregnancy pathology via effects on the regulation of angiogenesis and placental development. This study aims to address the effects of maternal obesity on macrophage subsets in the decidua of women with term uncomplicated pregnancies. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.01.002DOI Listing
February 2019

Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization.

Cell Immunol 2019 Mar 11;337:15-21. Epub 2019 Jan 11.

Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, China; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

As an atypical guanine nucleotide exchange factor (GEF), Dock5 has been extensively studied in cellular functions. However, the role of Dock5 on B-cell immunity still remain elusive. In this study, we generated a Dock5 knockout mouse model to study the effect of Dock5 deficiency on B cell development, differentiation and BCR signaling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183046
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http://dx.doi.org/10.1016/j.cellimm.2019.01.001DOI Listing
March 2019
11 Reads
1.924 Impact Factor

Modulation of autoimmune arthritis by environmental 'hygiene' and commensal microbiota.

Cell Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Medicine, Division of Rheumatology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Baltimore VA Medical Center, Baltimore, MD 21201, United States. Electronic address:

Observations in patients with autoimmune diseases and studies in animal models of autoimmunity have revealed that external environmental factors including exposure to microbes and the state of the host gut microbiota can influence susceptibility to autoimmunity and subsequent disease development. Mechanisms underlying these outcomes continue to be elucidated. These include deviation of the cytokine response and imbalance between pathogenic versus regulatory T cell subsets. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.005DOI Listing
December 2018
8 Reads

Natural killer T cells and ulcerative colitis.

Cell Immunol 2019 Jan 18;335:1-5. Epub 2018 Aug 18.

State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai 200127, China. Electronic address:

Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease (IBD). Both innate immunity and adaptive immunity are aberrant in IBD. The pathogenesis of UC includes abnormal inflammation and immune responses of the digestive tract. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.08.010DOI Listing
January 2019
4 Reads

Specific T-cell receptor gene transfer enhances immune response: A potential therapeutic strategy for the control of human cytomegalovirus infection in immunocompromised patients.

Cell Immunol 2019 Feb 2;336:58-65. Epub 2019 Jan 2.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China. Electronic address:

Human cytomegalovirus (HCMV) infection is a leading cause of morbidity and mortality in immunocompromised patients, but no specific therapeutic strategy is effective clinically, despite recent achievements. HCMV-specific T-cell therapy was thought to be helpful for the management of HCMV infection. To conduct a deep exploration, we investigated the possibility of engineering peripheral blood mononuclear cells (PBMCs) from immunocompetent and immunocompromised subjects with specific T-cell receptor (TCR) genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183048
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http://dx.doi.org/10.1016/j.cellimm.2018.12.011DOI Listing
February 2019
9 Reads

Epigenetic modulation enhances immunotherapy for hepatocellular carcinoma.

Cell Immunol 2019 Feb 2;336:66-74. Epub 2019 Jan 2.

Division of Surgical Oncology, Hiram C. Polk Jr. M.D. Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40202, USA; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA. Electronic address:

Background: Anti-PDL-1 immunotherapy for Hepatocellular Carcinoma (HCC) demonstrated a mixed response. Polycomb Repressor Complex 2(PRC2) contributes to the initiation and progression of HCC by suppressing tumor antigens and inhibiting an immune response. Two components of epigenetic modulation are Enhancer of Zeste Homolog 2 (EZH2, the catalytic component of PRC2) and DNA Methyltransferase 1 (DNMT1). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183045
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http://dx.doi.org/10.1016/j.cellimm.2018.12.010DOI Listing
February 2019
15 Reads
1.924 Impact Factor

Noradrenaline through β-adrenoceptor contributes to sexual dimorphism in primary CD4+ T-cell response in DA rat EAE model?

Cell Immunol 2019 Feb 26;336:48-57. Epub 2018 Dec 26.

Department of Physiology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, 11221 Belgrade, Serbia. Electronic address:

Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4+ T-cell (auto)immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (β-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4+ T cells from female and male EAE rat draining lymph node (dLN) cell cultures was examined. Male rat dLNs exhibited higher noradrenaline concentration and frequency of β-adrenoceptor-expressing CD4+ T lymphocytes and antigen presenting cells. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.009DOI Listing
February 2019
1 Read

ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase.

Cell Immunol 2019 Feb 21;336:40-47. Epub 2018 Dec 21.

Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, 210008 Nanjing, Jiangsu Province, China. Electronic address:

During the process of NAFLD progression, ER-stress is activated in macrophages and induces the pro-inflammatory polarization of macrophage. As one of the three ER membrane resident proteins, pancreatic eIF-2alpha kinase (PERK) plays an important role in ER stress, but its participation in macrophage polarization is largely unknown. In this study, we found that the PA mediated ER-stress activation could induce M1-type polarization in macrophages, and this phenotype polarization could be inhibited by ER-stress inhibitor 4-PBA as well as GSK2656157, an inhibitor of PERK. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183038
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http://dx.doi.org/10.1016/j.cellimm.2018.12.008DOI Listing
February 2019
18 Reads

CDR3 repertoire diversity of CD8+ T lymphocytes in patients with HCV.

Cell Immunol 2019 Feb 20;336:34-39. Epub 2018 Dec 20.

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; Engineering Key Laboratory for Cell Therapy of Henan Province, Zhengzhou, Henan 450052, China; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China. Electronic address:

T cell receptors (TCR) diversity is known to serve as a defining hallmark of the antigen-reactive T cell repertoire. Complementarity determining region 3 (CDR3) was the most important region for the recognition of peptide-major histocompatibility complex (MHC) complexes and represented the diversity of TCR repertoire. In this study, we detected the CDR3 spectratypes by complexity scoring system to assess TCR repertoire diversity and further analyzed the correlation of CDR3 score with CD8+ T cell function and with the prognosis of chronic hepatitis C virus (HCV)-infected patients. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.007DOI Listing
February 2019
2 Reads
1.924 Impact Factor

Targeting antigen presentation in autoimmunity.

Authors:
Jason R Lees

Cell Immunol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address:

Autoimmune diseases are heterogeneous group of disorders that together represent an enormous societal and medical problem. CD4+ T cells have critical roles in the initiation and pathogenesis of autoimmune disease. As such, modulation of T cell activity has proven to have significant therapeutic effects in multiple autoimmune settings. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.006DOI Listing
December 2018
9 Reads

Special Issue: The role of glycans in immunity and disease.

Cell Immunol 2018 Nov;333

Department of Pathology, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, Ohio, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183051
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http://dx.doi.org/10.1016/j.cellimm.2018.11.006DOI Listing
November 2018
14 Reads

Immune response in the relapsing-remitting experimental autoimmune encephalomyelitis in mice: The role of the NF-κB signaling pathway.

Cell Immunol 2019 Feb 8;336:20-27. Epub 2018 Dec 8.

Institute of Cell Biophysics, Pushchino, Moscow Region 142290, Russia.

Characteristics of the mouse model of relapsing-remitting experimental autoimmune encephalomyelitis (rEAE) closely resemble manifestations of multiple sclerosis in humans. In the present study, we investigated the mechanisms of inflammatory response, focusing on NF-κB pathway activation. Cytokine response in rEAE mice was multiphasic: the early phase was characterized by the increase in interferon-γ level in plasma. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.003DOI Listing
February 2019
3 Reads

Erythroid differentiation regulator 1 strengthens TCR signaling in thymocytes by modulating calcium flux.

Cell Immunol 2019 Feb 5;336:28-33. Epub 2018 Dec 5.

Institute of Convergence Science, Korea University, Anam-ro 145, Seongbuk-ku, Seoul 02841, Republic of Korea. Electronic address:

Erythroid differentiation regulator 1 (Erdr1) has been identified as a stromal survival factor released under stressful conditions. Previously, Erdr1 was reported to be expressed highly in thymus, but roles of Erdr1 in thymus were not known. Here, the effects of Erdr1 on T cell development were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183041
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http://dx.doi.org/10.1016/j.cellimm.2018.12.004DOI Listing
February 2019
8 Reads

Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease.

Cell Immunol 2019 Feb 4;336:12-19. Epub 2018 Dec 4.

School of Biological Sciences, University of Wollongong, Wollongong, NSW 2252, Australia; Molecular Horizons, University of Wollongong, NSW 2252, Australia; Illawarra Health and Medical Research Institute, Wollongong, NSW 2252, Australia. Electronic address:

Allogeneic haematopoietic stem cell transplantation (HSCT) is a frequent curative therapy for numerous haematological malignancies. However, HSCT is limited by the occurrence of graft-versus-host disease (GVHD), with current therapies restricted to general immunosuppression. Activation of the P2X7 receptor by extracellular adenosine triphosphate (ATP) causes inflammation and tissue damage in GVHD. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.001DOI Listing
February 2019
2 Reads

Platelet-derived microparticles generated in vitro resemble circulating vesicles of patients with rheumatoid arthritis and activate monocytes.

Cell Immunol 2019 Feb 4;336:1-11. Epub 2018 Dec 4.

Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia. Electronic address:

Patients with rheumatoid arthritis (RA) have increased amount of platelet-derived microparticles (PMPs) positive for citrullinated peptides (CPs) that form immune complexes (PMPs-ICs). Monocytes are important inflammatory mediators that play a role in the clearance of PMPs-ICs. We aimed to generate PMPs-ICs in vitro and determine its effect on monocytes from patients with RA and healthy individuals (HI). Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.12.002DOI Listing
February 2019
3 Reads

Eomesodermin driven IL-10 production in effector CD8 T cells promotes a memory phenotype.

Cell Immunol 2019 Jan 1;335:93-102. Epub 2018 Dec 1.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address:

CD8 T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-10 drive a central memory phenotype in murine CD8 T cells. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449173PMC
January 2019
1 Read

Mannosylated structures of mycobacterial lipoarabinomannans facilitate the maturation and activation of dendritic cells.

Cell Immunol 2019 Jan 30;335:85-92. Epub 2018 Nov 30.

Shanghai Public Health Clinical Center, Shanghai, China; Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Lipoarabinomannan (LAM) is an important virulent factor secreted by mycobacteria, which generally elicit a strong immune response in the host. In this study, the structural difference of LAMs from three mycobacterial strains, Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis mc155 and a newly discovered clinical isolate, M. sp. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183033
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http://dx.doi.org/10.1016/j.cellimm.2018.11.007DOI Listing
January 2019
2 Reads

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells.

Cell Immunol 2018 Nov 9. Epub 2018 Nov 9.

Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium. Electronic address:

Antigen receptor-induced signaling plays an important role in inflammation and immunity. Formation of a CARD11-BCL10-MALT1 (CBM) signaling complex is a key event in T- and B cell receptor-induced gene expression by regulating NF-κB activation and mRNA stability. Deregulated CARD11, BCL10 or MALT1 expression or CBM signaling have been associated with immunodeficiency, autoimmunity and cancer, indicating that CBM formation and function have to be tightly regulated. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.11.001DOI Listing
November 2018
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Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells.

Cell Immunol 2018 Sep 29. Epub 2018 Sep 29.

Department of Microbiology and Immunology, University of Illinois - College of Medicine, Chicago, IL, USA. Electronic address:

Self-tolerance, the state of unresponsiveness to self-tissues/antigens, is maintained through central and peripheral tolerance mechanisms, and a breach of these mechanisms leads to autoimmune diseases. Foxp3 + T-regulatory cells (Tregs) play an essential role in suppressing autoimmune response directed against self-antigens and thereby regulate self-tolerance. Natural Tregs are differentiated in the thymus on the basis of their higher TCR-affinity to self-antigens and migrate to the periphery where they maintain peripheral tolerance. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440877PMC
September 2018
17 Reads
1.924 Impact Factor

Local and systemic production of proinflammatory chemokines in the pathogenesis of HAM/TSP.

Cell Immunol 2018 Dec 6;334:70-77. Epub 2018 Oct 6.

Immunology Service, University Hospital Complex Professor Edgard Santos (ComHUPES), Federal University of Bahia (UFBA), Salvador, Bahia, Brazil; Department of Biological Sciences, State University of Feira de Santana (UEFS), Bahia, Brazil. Electronic address:

Background: HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is related with high proviral load, high proinflammatory cytokine levels, and passage of infected cell from the blood to the central nervous system. We aimed to evaluate the participation of chemokines and adhesion molecules in HAM/TSP pathogenesis.

Methods: CXCL9, CXCL10, sICAM-1, and sVCAM-1 were determined by ELISA in serum and cerebrospinal fluid (CSF) of HTLV-1 infected individuals. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.09.009DOI Listing
December 2018
14 Reads

NK cells suppress CD8 T cell immunity via NKG2D in severe aplastic anemia.

Cell Immunol 2019 Jan 12;335:6-14. Epub 2018 Oct 12.

Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, PR China. Electronic address:

The roles of natural killer (NK) cells in shaping the immune system had raised wide interests. Here we intended to explore the regulatory functions of NK cells on CD8 T cells in severe aplastic anemia (SAA) using human participants and lymphocyte infusion-induced bone marrow failure (BMF) mouse model. In SAA patients, NK cells had over-expressions of NKG2D and NKp46, under-expression of NKG2A and enhanced cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.10.004DOI Listing
January 2019
26 Reads

Regulation of immune responses by E3 ubiquitin ligase Cbl-b.

Cell Immunol 2018 Nov 7. Epub 2018 Nov 7.

Department of Pathology, The University of Iowa, Iowa City, IA, USA. Electronic address:

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate that Cbl-b also modulates innate immune responses, and plays a key role in host defense to pathogens and anti-tumor immunity. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.11.002DOI Listing
November 2018
13 Reads
1.924 Impact Factor

Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells.

Cell Immunol 2019 Jan 7;335:68-75. Epub 2018 Nov 7.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA. Electronic address:

CD4+ T cell responses are thought to play a role in type 1 diabetes (T1D). However, detection and characterization of T cells that respond to beta cell epitopes in subjects with T1D has been limited by technical obstacles, including the inherently low frequencies in peripheral blood and variable responsiveness of individual subjects to single epitopes. We implemented a multicolor staining approach that allows direct ex vivo characterization of multiple CD4+ T cell specificities in a single sample. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.11.004DOI Listing
January 2019
1 Read

Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites.

Cell Immunol 2019 Jan 7;335:76-84. Epub 2018 Nov 7.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL. Rua da Junqueira 100, 1349-008 Lisboa, Portugal. Electronic address:

Neutrophils are short-lived phagocytic cells equipped with several receptors for pathogen recognition and phagocytosis and have intracellular and extracellular effector mechanisms that can inactivate pathogens. Leishmaniases are diseases caused by different species of Leishmania that mainly afflicts poorer populations of tropical and subtropical regions and immunocompromised individuals. Thus, the present study aims to investigate the effector response of murine neutrophils to species of Leishmania causing American cutaneous leishmaniasis and zoonotic visceral leishmaniasis by evaluating pattern recognition receptors (PRR) and intracellular and extracellular effector microbicide activity. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.11.003DOI Listing
January 2019
5 Reads

Identification of MΦ specific POTEE expression: Its role in mTORC2 activation via protein-protein interaction in TAMs.

Cell Immunol 2019 Jan 3;335:30-40. Epub 2018 Nov 3.

Toxicology and Experimental Medicine Division, CSIR-Central Drug Research Institute, Sector-10, Janakipuram Extension, Sitapur Road, Lucknow 226031, U.P., India. Electronic address:

POTE is known as cancer antigen, expressed in many cancers, along with very few normal tissues like prostate, ovary, testes and embryo. Till date, POTEE identified as majorly expressed POTE paralog. Functionally, POTEF regulates TLR signaling which play important role in innate immunity provided clue about expression of POTE in immune cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183035
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http://dx.doi.org/10.1016/j.cellimm.2018.10.010DOI Listing
January 2019
9 Reads

Regulation of host cell pyroptosis and cytokines production by Mycobacterium tuberculosis effector PPE60 requires LUBAC mediated NF-κB signaling.

Cell Immunol 2019 Jan 30;335:41-50. Epub 2018 Oct 30.

Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China. Electronic address:

Tuberculosis, caused by Mycobacterium tuberculosis infection, remains a global public health threat. The success of M. tuberculosis largely contributes to its manipulation of host cell fate. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183034
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http://dx.doi.org/10.1016/j.cellimm.2018.10.009DOI Listing
January 2019
24 Reads

Triggering of CD99 on monocytes by a specific monoclonal antibody regulates T cell activation.

Cell Immunol 2019 Jan 2;335:51-58. Epub 2018 Nov 2.

Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency at the Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

CD99, a leukocyte surface glycoprotein, has been implicated in many cellular processes including cell adhesion, cell migration and T cell activation. Our previous study demonstrated the anti-CD99 monoclonal antibody (mAb) clone MT99/3 inhibited T cell activation; however, the mechanism is unclear. In this study, we demonstrated that CD99 expressed on monocytes played a role in the inhibition of T cell activation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.10.012DOI Listing
January 2019
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Hepatocellular cancer-derived alpha fetoprotein uptake reduces CD1 molecules on monocyte-derived dendritic cells.

Cell Immunol 2019 Jan 1;335:59-67. Epub 2018 Nov 1.

UPMC Hillman Cancer Center, Pittsburgh, PA, United States; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address:

Alpha fetoprotein (AFP) is produced by over 50% of hepatocellular carcinomas (HCC). Uptake of tumor-derived AFP (tAFP) can impair activity of human dendritic cells (DC). The expression pattern of the lipid antigen presenting genes from the CD1 family is reduced in AFP-treated monocyte-derived DC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183036
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http://dx.doi.org/10.1016/j.cellimm.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368446PMC
January 2019
16 Reads

Artificial antigen-presenting cells are superior to dendritic cells at inducing antigen-specific cytotoxic T lymphocytes.

Cell Immunol 2018 Dec 23;334:78-86. Epub 2018 Oct 23.

The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China. Electronic address:

Adoptive immunotherapy is a promising cancer treatment that entails infusion of immune cells manipulated to have antitumor specificity, in vitro. Antigen-specific cytotoxic T lymphocytes are the main executors of transformed cells during cancer immunotherapy. To induce antigen-specific cytotoxic T lymphocytes, we developed artificial antigen-presenting cells (aAPCs) by engineering K562 cells with electroporation to direct the stable expression of HLA-A∗0201, CD80, and 4-1BBL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183045
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http://dx.doi.org/10.1016/j.cellimm.2018.10.002DOI Listing
December 2018
14 Reads
1.924 Impact Factor

In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice.

Cell Immunol 2019 Jan 26;335:22-29. Epub 2018 Oct 26.

Department of Allied Health Sciences, University of Connecticut, Storrs, CT, United States; University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, United States. Electronic address:

Although hematopoietic stem cell transplantation (HSCT) has been widely used in the treatment of many diseases, graft-versus-host disease (GVHD) remains a major complication after allogeneic HSCT. Butyrophilin-like 2 (BTNL2) protein has been reported to have the ability to inhibit T cell proliferation in vitro; its ability to inhibit T cell responses in vivo has not been determined. We show here that in vivo administration of recombinant BTNL2-IgG2a Fc (rBTNL2-Ig) fusion protein ameliorates GVHD in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00088749183036
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http://dx.doi.org/10.1016/j.cellimm.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368466PMC
January 2019
14 Reads

HIF-1α-regulated MIF activation and Nox2-dependent ROS generation promote Leishmania amazonensis killing by macrophages under hypoxia.

Cell Immunol 2019 Jan 22;335:15-21. Epub 2018 Oct 22.

Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP, CONICET-GCBA), Servicio de Parasitología-Chagas, Hospital de Niños "Dr. Ricardo Gutiérrez", Buenos Aires, Argentina. Electronic address:

Increasing attention is given to the finding that macrophages under hypoxia are capable of controlling infection by the intracellular protozoan parasite Leishmania amazonensis. The hypoxia-inducible factor (HIF)-1α has been shown to play an essential role in this enhanced innate immune response. Our study aimed to explore the HIF-1α-dependent mechanisms leading to reduced survival of the parasites residing in macrophages under low oxygen conditions. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.10.007DOI Listing
January 2019
4 Reads

Role of the intestinal microbiome in autoimmune diseases and its use in treatments.

Cell Immunol 2018 Oct 19. Epub 2018 Oct 19.

Department of Immunology and Rheumatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

The role of the intestinal microbiome in the pathogenesis of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and type 1 diabetes is being increasingly appreciated. Many studies have reported that the compositions of the intestinal microbiomes of patients with these autoimmune diseases are different from those of healthy individuals. Analyses of the intestinal microbiome of humans suggest that various factors affect the composition of the intestinal microbiome, including, but not limited to: geographical location, diet, sex, and age. Read More

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http://dx.doi.org/10.1016/j.cellimm.2018.10.005DOI Listing
October 2018
1 Read