10,332 results match your criteria Cellular Immunology [Journal]


Dietary oligosaccharides attenuate DSS-induced colitis in mice, induce PGlyRP3 expression, and inhibit NF-κB and MEK/ERK signaling.

Authors:
Ayman Hyder

Cell Immunol 2020 Jun 10;354:104144. Epub 2020 Jun 10.

Faculty of Science, Damietta University, New Damietta 34517, Egypt. Electronic address:

Peptidoglycan recognition protein 3 (PGlyRP3) is a pattern recognition protein found in the gut epithelia and proven to have an anti-inflammatory effect in response to dietary lipids via the upregulation of PPARγ. We have reported an in vitro anti-inflammatory action for prebiotic oligosaccharides in the intestinal Caco-2 cells through stimulation of PPARγ and PGlyRP3. In the present study, this effect was examined in vivo in a DSS-induced colitis mouse model. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104144DOI Listing

IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8 T cells in high dimensional analysis.

Cell Immunol 2020 Jun 24;355:104155. Epub 2020 Jun 24.

Departments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

The IL-7 receptor alpha chain (IL-7Rα or CD127) can be differentially expressed in memory CD8 T cells. Here we investigated whether IL-7Rα could serve as a key molecule in defining a comprehensive landscape of heterogeneity in human effector memory (EM) CD8 T cells using high-dimensional Cytometry by Time-Of-Flight (CyTOF) and single-cell RNA-seq (scRNA-seq). IL-7Rα had diverse, but organized, expressional relationship in EM CD8 T cells with molecules related to cell function and gene regulation, which rendered an immune landscape defining heterogeneous cell subsets. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104155DOI Listing

Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology.

Cell Immunol 2020 Jun 27;355:104156. Epub 2020 Jun 27.

Department of Medicine, University of Chicago, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2020.104156DOI Listing

Combined TLR4 and TLR9 agonists induce distinct phenotypic changes in innate immunity in vitro and in vivo.

Cell Immunol 2020 Jun 14;355:104149. Epub 2020 Jun 14.

School of Biological Sciences, University of Nebraska-Lincoln, NE 68583, USA; Nebraska Center for Virology, University of Nebraska-Lincoln, NE 68583, USA. Electronic address:

Toll-like receptor (TLR)4 and TLR9 agonists, MPL and CpG, are used as adjuvants in vaccines and have been investigated for their combined potential. However, how these two combined agonists regulate transcriptional changes in innate immune cells and cells at the site of vaccination has not been thoroughly investigated. Here, we utilized transcriptomics to investigate how CpG, MPL, and CpG + MPL impact gene expression in dendritic cells (DC) in vitro. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104149DOI Listing

Stimulation with FITC-labeled antigens confers B cells with regulatory properties.

Cell Immunol 2020 Jun 12;355:104151. Epub 2020 Jun 12.

Centre de recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.

B cells with regulatory properties (Bregs) were identified in human and in mice among different B-cell subsets. Their regulatory properties rely mainly on the production of anti-inflammatory cytokines, in particular IL10, IL-35 and TGFβ, and were extensively studied in mouse models of autoimmune and inflammatory diseases. However, the exact nature of the stimulatory signals conferring regulatory properties to B cells is still not clear. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104151DOI Listing

Regulation and dysregulation of CARD14 signalling and its physiological consequences in inflammatory skin disease.

Authors:
Mark Mellett

Cell Immunol 2020 Jun 13;354:104147. Epub 2020 Jun 13.

Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland. Electronic address:

CARD14 is a scaffold molecule predominantly expressed in keratinocytes and genetic variants in the CARD14 gene confer an increased risk of inflammatory skin disease. Due to its association with common skin diseases psoriasis and atopic dermatitis, the biological function of CARD14 is of relevant interest to human health. CARD14 recruits BCL10 and MALT1 to form the CARD-BCL10-MALT1 complex, which modulates NF-κB and MAPK signalling pathways, yet little is known about how CARD14 is regulated or activated in the context of the innate immune response and in chronic inflammation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104147DOI Listing

Promoter anchored interaction landscape of THP-1 macrophages captures early immune response processes.

Cell Immunol 2020 Jun 12;355:104148. Epub 2020 Jun 12.

KTH Royal Institute of Technology, School of Chemistry, Biotechnology and Health, Science for Life Laboratory, Tomtebodavägen 23A, 171 65 Stockholm, Sweden. Electronic address:

Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulated THP-1 macrophages (0 and 2 h) using capture Hi-C. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104148DOI Listing

Infectious tolerance. What are we missing?

Cell Immunol 2020 Jun 12;354:104152. Epub 2020 Jun 12.

Instituto de Medecina Molecular, Faculdade de medicina da Universidade de Lisboa, Avenida professor Egas Moniz, 1649-028 Lisboa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2020.104152DOI Listing

Recombinant Rv3261 protein of Mycobacterium tuberculosis induces apoptosis through a mitochondrion-dependent pathway in macrophages and inhibits intracellular bacterial growth.

Cell Immunol 2020 Jun 12;354:104145. Epub 2020 Jun 12.

Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea; Infection Control Convergence Research Center, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Electronic address:

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen known to persist in host cells. The apoptotic response of macrophages serves as a defense mechanism to inhibit the growth of intracellular bacteria, the failure of which can favor the spread of the pathogen to new cells. However, the mycobacterial components that regulate cell death and the related underlying mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104145DOI Listing

Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity.

Cell Immunol 2020 Jun 4;354:104143. Epub 2020 Jun 4.

Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No.1160 Shengli South Street, Yinchuan 750004, PR China. Electronic address:

Immunization with synthetic mRNA encoding tumor-associated antigens is an emerging vaccine strategy for the treatment of cancer. In order to prevent mRNA degradation, promote antigen-presenting cells antigen presentation, and induce an anti-tumor immune response, we investigated the nasal administration of mRNA vaccines with positively charged protamine to concentrate mRNA, form a stable polycation-mRNA complex, and encapsulate the complex with DOTAP/Chol/DSPE-PEG cationic liposomes. Cationic liposome/protamine complex (LPC) showed significantly greater efficiency in uptake of vaccine particles in vitro and stronger capacities to stimulate dendritic cell maturation, which further induced a potent anti-tumor immune response. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104143DOI Listing

Surviving the storm: Dealing with COVID-19.

Cell Immunol 2020 Jun 13;354:104153. Epub 2020 Jun 13.

Neuroimmunology Research, R&D-31, VA Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR 97239, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.cellimm.2020.104153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293470PMC

Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural.

Cell Immunol 2020 May 19;354:104131. Epub 2020 May 19.

University of Cambridge, School of Clinical Medicine, Cambridge CB2 0QQ, UK. Electronic address:

Non-HLA antibody responses following solid organ transplantation have become increasingly emphasised, with several large clinical series suggesting that such responses contribute to late graft failure. Many of the responses described recognise both recipient and donor moieties of the target antigen and thus represent auto-, rather than allo-immunity. Within this rapidly evolving field, many questions remain unanswered: what triggers the response; how innate and adaptive humoral autoimmunity integrate; and most pressingly, how autoimmunity contributes to graft damage and its relationship to other effector mechanisms of graft rejection. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104131DOI Listing

Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.

Cell Immunol 2020 Jul 14;353:104129. Epub 2020 May 14.

Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of Health Sciences, Bethesda, MD, United States. Electronic address:

BENTA (B cell Expansion with NF-κB and T cell Anergy) is a novel lymphoproliferative disorder caused by germline, gain-of-function (GOF) mutations in the lymphocyte-restricted scaffolding protein CARD11. Similar somatic CARD11 mutations are found in lymphoid malignancies such as diffuse large B cell lymphoma (DLBCL). Normally, antigen receptor (AgR) engagement converts CARD11 into an active conformation that nucleates a signalosome required for IκB kinase (IKK) activation and NF-κB nuclear translocation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104129DOI Listing

The LUBAC participates in lysophosphatidic acid-induced NF-κB activation.

Cell Immunol 2020 Jul 18;353:104133. Epub 2020 May 18.

Université de Nantes, INSERM, CNRS, CRCINA, Team SOAP, F-440000 Nantes, France. Electronic address:

The natural bioactive glycerophospholipid lysophosphatidic acid (LPA) binds to its cognate G protein-coupled receptors (GPCRs) on the cell surface to promote the activation of several transcription factors, including NF-κB. LPA-mediated activation of NF-κB relies on the formation of a signalosome that contains the scaffold CARMA3, the adaptor BCL10 and the paracaspase MALT1 (CBM complex). The CBM complex has been extensively studied in lymphocytes, where it links antigen receptors to NF-κB activation via the recruitment of the linear ubiquitin assembly complex (LUBAC), a tripartite complex of HOIP, HOIL1 and SHARPIN. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104133DOI Listing

Engagement of CD45 alters early signaling events in human T cells co-stimulated through TCR + CD28.

Cell Immunol 2020 Jul 13;353:104130. Epub 2020 May 13.

Department of Molecular Biosciences, University of Kansas, Lawrence, KS, United States.

Previously our lab has shown that co-stimulation of human T cells through different co-stimulatory molecules tune differentiation to different phenotypes. An open question is where in the signaling pathways induced by the co-stimulation do differences occur that contribute to outcome of differentiation. In this project, we investigate the early signaling process by comparing events that follow engagement of CD45 alone or in association with a co-stimulatory molecule: CD28. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104130DOI Listing

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis.

Cell Immunol 2020 Jul 4;353:104119. Epub 2020 May 4.

Clinical Research Institute, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, China. Electronic address:

Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor microenvironment (TME). There is growing evidence that TAMs are involved in tumor progression via multiple mechanisms. TAMs create an immunosuppressive TME by producing growth factors, chemokines, and cytokines which modulate recruitment of immune cells and inhibit anti-tumor responses. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104119DOI Listing

NK cells modulate T cell responses via interaction with dendritic cells in Chlamydophila pneumoniae infection.

Cell Immunol 2020 Jul 16;353:104132. Epub 2020 May 16.

Departments of Immunology and Medical Microbiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada. Electronic address:

Protective immune response to chlamydial infection is largely dependent on cell-mediated immune responses with IFN-γ production. Recent studies have shown the critical role of NK cells in bridging innate and adaptive immune responses. In this study, we investigated the effect of NK cells on T cell responses during Chlamydophila pneumoniae (Cpn) lung infection. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104132DOI Listing

Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state.

Cell Immunol 2020 Jul 6;353:104118. Epub 2020 May 6.

Guangdong Province Key Laboratory of Biotechnology Drug Candidates, Guangdong Pharmaceutical University, Guangzhou, China; School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address:

The in vivo proliferation and viability of transfused engineered T cells markedly limits the long-term effect of adoptive cell therapy on tumors. The therapeutic efficacy and proliferative potential of T cells are reported to be dependent on the differentiation status of T cells. The T cells at the early stage of progressive differentiation have a long lifespan, strong proliferative potential, and the ability to reconstruct intact T cell subsets. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104118DOI Listing

B cell depletion in murine lupus using cytotoxic T lymphocytes in vivo: Feasibility and benefit.

Cell Immunol 2020 Jul 5;353:104117. Epub 2020 May 5.

Department of Pathology, Uniformed Services University, Bethesda, MD 20814, United States. Electronic address:

Given the promising results in human lupus with B cell depletion, we tested whether in vivo cytotoxic T lymphocyte (CTL) could eliminate autoreactive B cells in the setting of murine lupus. Using the parent-into-F1 (P → F1) model to generate CTL that eliminate B cells, we found that transfer ofNZB parental splenocytes into lupus-prone female NZB/W F1 mice resulted in profound B cell reduction whereas NZW → F1 mice exhibited defective B cell elimination. Using pre-disease or early disease B/W mice as hosts, NZB → F1 mice exhibited B cell depletion and improved proteinuria but no improvement in survival whereas NZW → F1 mice had significantly reduced proteinuria and prolonged survival. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104117DOI Listing

TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling.

Cell Immunol 2020 Jul 28;353:104115. Epub 2020 Apr 28.

CRCINA, Team SOAP, INSERM, CNRS, Université de Nantes, Université d'Angers, IRS-UN blg, Room 405, 8 quai Moncousu, Nantes 44007, France; L'Héma-NexT, i-Site NexT, Nantes, France; GDR3697 Micronit, CNRS, Nantes, France. Electronic address:

The CARMA1-BCL10-MALT1 (CBM) complex couples antigen receptors to the activation of Nuclear Factor κB (NF-κB) transcription factors in T/B lymphocytes. Within this signalosome, the MALT1 paracaspase serves dual roles: it is a crucial adaptor for signal transduction to NF-κB signaling, and a protease that shapes NF-κB activity and lymphocyte activation. Although a subtle choreography of ubiquitination and phosphorylation orchestrate the CBM, how precisely this complex and MALT1 enzyme are regulated continue to be elucidated. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104115DOI Listing

Cytokine stimulation of the choriocarcinoma cell line JEG-3 leads to alterations in the HLA-G expression profile.

Cell Immunol 2020 Jun 7;352:104110. Epub 2020 Apr 7.

Center for Immune Regulation and Reproductive Immunology (CIRRI), The ReproHealth Consortium ZUH, Department of Clinical Biochemistry, Zealand University Hospital, and the Department of Clinical Medicine, University of Copenhagen, Denmark.

The checkpoint molecule human leukocyte antigen (HLA)-G has restricted tissue expression, and plays a role in the establishment of maternal tolerance to the semi-allogenic fetus during pregnancy by expression on the trophoblast cells in the placenta. HLA-G exists in at least seven well-described mRNA isoforms, of which four are membrane-bound and three soluble. Regulation of the tissue expression of HLA-G and its isoforms is relatively unknown. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104110DOI Listing

An accumulation of two populations of dendritic cells in skin-draining lymph nodes in response to the expression of thymic stromal lymphopoietin in the skin.

Cell Immunol 2020 Jul 29;353:104116. Epub 2020 Apr 29.

Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo, Japan.

Thymic stromal lymphopoietin (TSLP) acts on dendritic cells (DCs), which prime helper T (Th) cells to become type 2 cytokine producing cells. Recently, a different set of populations of TSLP-responsive DCs has been discovered. Here, we identified two populations of CD103EpCAM migratory DCs (fraction I and fraction II) that accumulated in skin-draining lymph nodes in response to TSLP expressed in the mouse skin. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104116DOI Listing

Protective immunity after COVID-19 has been questioned: What can we do without SARS-CoV-2-IgG detection?

Cell Immunol 2020 07 28;353:104114. Epub 2020 Apr 28.

Laboratory of Immunological Technology, Immunobiological Technology Institute, Bio-Manguinhos, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187813PMC

The effects of delta-9-tetrahydrocannabinol (THC) on inflammation: A review.

Cell Immunol 2020 Apr 20;352:104111. Epub 2020 Apr 20.

Division of Surgical Research, Cooper University Hospital, Camden, NJ, USA. Electronic address:

THC is the main psychoactive compound found in marijuana. A number of studies over the past few decades, both in vitro and in vivo, have demonstrated that THC down-regulates the inflammatory process through various mechanisms. Similar findings have been demonstrated with CBD, the other major bioactive component of marijuana. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104111DOI Listing

IL-1β enhances human placenta-derived mesenchymal stromal cells ability to mediate Th1/Th2 and Th1/CD4IL-10 T cell balance and regulates its adhesion, proliferation and migration via PD-L1.

Cell Immunol 2020 Jun 13;352:104113. Epub 2020 Apr 13.

Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China. Electronic address:

Human placenta-derived mesenchymal stromal cells (hPMSCs) are promising candidates for the treatment of graft-versus-host disease (GVHD), which is associated with high IL-1β levels. In this study, the effects of IL-1β and hPMSCs on each other were investigated by analyzing the proportion of Th1, Th2 and CD4IL-10 T cells and PD-L1 expression, as well as the adhesion, migration, and proliferation of hPMSCs. The results showed that hPMSCs decreased IL-1β levels and downregulated Th1/Th2 and Th1/CD4IL-10 T cells ratios in the GVHD model. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104113DOI Listing

Combined antitumor effects of anti-EGFR variant III CAR-T cell therapy and PD-1 checkpoint blockade on glioblastoma in mouse model.

Cell Immunol 2020 Jun 9;352:104112. Epub 2020 Apr 9.

Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, PR China; Beijing DCTY® Biotech CO., LTD, Beijing 102200, PR China. Electronic address:

Glioblastoma is one of the deadliest cancers. Chimeric antigen receptor (CAR)-T cell therapy against solid tumors has been far from satisfactory largely due to the immunosuppressive tumor microenvironment, such as PD-1 mediated T cell exhaustion. In the present study, we investigated the combined antitumor effects of anti-EGFR variant III CAR-T cell therapy and PD-1 checkpoint blockade on glioblastoma in mouse model. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104112DOI Listing

Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.

Cell Immunol 2020 Jun 2;352:104100. Epub 2020 Apr 2.

Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, NHC Key Laboratory of Medical Immunology, Beijing, China; Peking University Center for Human Disease Genomics, Beijing, China. Electronic address:

B-1a cells represent a distinct B cell population with unique phenotype, self-renewing capacity and restricted Igμ repertoire. They primarily locate in body cavity and also exist in spleen. The different subpopulations of B-1a cells are heavily affected by local environment. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104100DOI Listing

Early recruited neutrophils promote asthmatic inflammation exacerbation by release of neutrophil elastase.

Cell Immunol 2020 Jun 3;352:104101. Epub 2020 Apr 3.

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Electronic address:

Neutrophils can regulate adaptive immune responses and contribute to chronic inflammation including asthma. However, the roles and mechanisms of neutrophils in initiating eosinophilic airway inflammation remain incompletely understood. Neutrophil elastase (NE) is a component of azurophilic granules and a serine protease with potent functions during inflammation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104101DOI Listing

Corrigendum to "Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization" [Cell. Immunol. 337 (2019) 15-21].

Cell Immunol 2020 May 2;351:104097. Epub 2020 Apr 2.

Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, China; Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2020.104097DOI Listing
May 2020
1.924 Impact Factor

Programmed T cell differentiation: Implications for transplantation.

Cell Immunol 2020 May 29;351:104099. Epub 2020 Mar 29.

Emory Transplant Center, Department of Surgery, Emory University, 101 Woodruff Circle, Suite 5208, Atlanta, GA 30322, United States. Electronic address:

While T cells play a critical role in protective immunity against infection, they are also responsible for graft rejection in the setting of transplantation. T cell differentiation is regulated by both intrinsic transcriptional pathways as well as extrinsic factors such as antigen encounter and the cytokine milieu. Herein, we review recent discoveries in the transcriptional regulation of T cell differentiation and their impact on the field of transplantation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198981PMC

IL-33 induced airways inflammation is partially dependent on IL-9.

Cell Immunol 2020 Jun 27;352:104098. Epub 2020 Mar 27.

Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address:

Asthma is an inflammatory disease of the airways and numerous cytokines contribute to this pathogenesis. It is shown that challenge of airways with IL-33 induces asthma-like pathological changes in mice, but the possible downstream cytokines in this process remain to be characterised. To explore this, we compared changes in the airways of wildtype (WT) and IL-9 deficient mice challenged with IL-33. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104098DOI Listing
June 2020
1.924 Impact Factor

Autophagy efficacy and vitamin D status: Population effects.

Cell Immunol 2020 Jun 28;352:104082. Epub 2020 Feb 28.

Department of Biochemistry, University of Johannesburg, Auckland Park Kingsway Campus, PO Box 524, Auckland Park 2006, Gauteng, South Africa. Electronic address:

Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D (1,25(OH)D)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are influenced by vitamin D status. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104082DOI Listing

HMGB1-induced ILC2s activate dendritic cells by producing IL-9 in asthmatic mouse model.

Cell Immunol 2020 Jun 6;352:104085. Epub 2020 Mar 6.

Department of Immunology, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Asthma is a disease of the respiratory system that is commonly considered a T-helper 2 (Th2) cell-associated inflammatory disease. Group 2 innate lymphoid cells (ILC2s) promote the inflammatory responses in asthma by secreting type 2 cytokines. Interleukin (IL)-9 also serves as a promoting factor in asthma and it is well known that ILC2s have an autocrine effect of IL-9 to sustain their survival and proliferation. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104085DOI Listing

CD4 T cell phenotypes in the pathogenesis of immune thrombocytopenia.

Cell Immunol 2020 May 14;351:104096. Epub 2020 Mar 14.

University of Nis, Medical Faculty of Nis, Department of Immunology, Blvd. dr Zorana Djindjica 81, 18000 Nis, Serbia; Clinical Centre Nis, Department of Hematology and Clinical Immunology, Vojislava Ilića 1, 18000 Nis, Serbia.

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts due to enhanced platelet clearance and compromised production. Traditionally, ITP was regarded a B cell mediated disorder as anti-platelet antibodies are detected in most patients. The very nature of self-antigens, evident processes of isotype switching and the affinity maturation of anti-platelet antibodies indicate that B cells in order to mount anti-platelet immune response require assistance of auto-reactive CD4 T cells. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104096DOI Listing
May 2020
1.924 Impact Factor

Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation.

Cell Immunol 2020 May 12;351:104087. Epub 2020 Mar 12.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

Nonhuman primates (NHP) are important pre-clinical models for evaluation of the safety and efficacy of the most promising potential therapeutic advances in organ transplantation based on rodent studies. Although rare, dendritic cells (DC) play important roles in preservation of self tolerance and DC with immunoregulatory properties (regulatory DC; DCreg) can promote transplant tolerance in rodents when adoptively transferred to allograft recipients. NHP DCreg can be generated ex vivo from bone marrow precursors or blood monocytes of cynomolgus or rhesus macaques or baboons. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197030PMC

Recent advances into the role of pattern recognition receptors in transplantation.

Cell Immunol 2020 May 7;351:104088. Epub 2020 Mar 7.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Pattern recognition receptors (PRRs) are germline-encoded sensors best characterized for their critical role in host defense. However, there is accumulating evidence that organ transplantation induces the release or display of molecular patterns of cellular injury and death that trigger PRR-mediated inflammatory responses. There are also new insights that indicate PRRs are able to distinguish between self and non-self, suggesting the existence of non-clonal mechanisms of allorecognition. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170002PMC

Corrigendum to "Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6" [Cell. Immunol. 349 (2020) 104047].

Cell Immunol 2020 May 11;351:104084. Epub 2020 Mar 11.

State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2020.104084DOI Listing

Reprint of "Multi-modal image cytometry approach - From dynamic to whole organ imaging".

Cell Immunol 2020 Apr 10;350:104086. Epub 2020 Mar 10.

Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, 8A Biomedical Grove, Singapore 138648, Singapore; National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore. Electronic address:

Optical imaging is a valuable tool to visualise biological processes in the context of the tissue. Each imaging modality provides the biologist with different types of information - cell dynamics and migration over time can be tracked with time-lapse imaging (e.g. Read More

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Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes.

Cell Immunol 2020 Jun 21;352:104078. Epub 2020 Feb 21.

Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA. Electronic address:

We delineated the expression of DAP12 (DNAX-Activating Protein) and its associated receptors, TREM-1, TREM-2 and MDL-1 in pig alveolar monocyte/macrophages (AMM) that have attained M1 or M2 phenotypes. Pig AMM stimulated in vitro with IFN-γ and IL-4 induced the expression of M1 (TNFα and iNOS) and M2 (ARG1 and no MMR) phenotypic markers, respectively. In influenza virus infected pigs at seven days post-infection, in addition to substantial modulations in the M1 and M2 markers expression, DAP12, TREM-1 and MDL-1 were downregulated in AMM. Read More

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NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice.

Cell Immunol 2020 Jun 27;352:104081. Epub 2020 Feb 27.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Mice that express a single transgenic T cell receptor have a low incidence of T cell lymphoma development. We investigated whether this tumor development is restricted by surveillance mechanisms that are exerted by IL-15-dependent cells. Lymphoma incidence was increased to between 30 and 60% when TCR transgenes were expressed in IL-15-deficient mice. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217732PMC

Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD-1T cells.

Cell Immunol 2020 Jun 28;352:104083. Epub 2020 Feb 28.

Department of Immunology, Binzhou Medical University, Yantai, Shandong Province 264003, People's Republic of China. Electronic address:

Aims: To investigate whether placenta-derived mesenchymal stromal cells (hPMSCs) have immunoregulatory effects on PD-1 T cell generation by controlling ROS production and thus alleviating GVHD.

Main Methods: Flow cytometry was used to analyze the percentage of PD-1 T cells, as well as the generation of ROS, GSH and GST in PD-1 T cells. The expression of GST in the spleen and liver was analyzed by western blotting. Read More

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Regulatory B cells in infection, inflammation, and autoimmunity.

Cell Immunol 2020 Jun 27;352:104076. Epub 2020 Feb 27.

Biological Sciences, College of Charleston, SC, United States; Biological Sciences, Trident Technical College, Charleston, SC, United States.

Regulatory B (Breg) cells are characterized by differential expression of CD5 and CD1d in mouse and CD24 and CD38 in human immune systems. The Breg family also includes LAG-3CD138 plasma cells, CD1d CD5 CD21 CD23 cells, Tim1, PD-L1, PD-L2, CD200- expressing B cells, and CD39Ki67 cells originating from the transitional, marginal zone or germinal centre of the spleen. Breg cells produce IL10 and IL35 and to cause immunosuppression. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104076DOI Listing
June 2020
1.924 Impact Factor

Exploiting immunometabolism and T cell function for solid organ transplantation.

Cell Immunol 2020 May 19;351:104068. Epub 2020 Feb 19.

Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, United States. Electronic address:

Cellular metabolism is central to T cell function and proliferation, with most of the research to date focusing on cancer and autoimmunity. Cellular metabolism is associated with a host of physiological phenomena, from epigenetic changes, to cellular function and fate. For the purpose of this review, we will discuss the metabolism of T cells relating to their differentiation and function. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150626PMC

Microbiota in organ transplantation: An immunological and therapeutic conundrum?

Cell Immunol 2020 May 27;351:104080. Epub 2020 Feb 27.

Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles 90095, CA, USA. Electronic address:

The gastrointestinal (GI) tract microbiota is an environmental factor that regulates host immunity in allo-transplantation (allo-Tx). It is required for the development of resistance against pathogens and the stabilization of mucosa-associated lymphoid tissue. The gut-microbiota axis may also precipitate allograft rejection by producing metabolites that activate host cell-mediated and humoral immunity. Read More

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Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor.

Cell Immunol 2020 May 22;351:104079. Epub 2020 Feb 22.

Department of Experimental Immunology, Faculty of Health Sciences, Medical University of Lodz, 92-213 Lodz, Poland.

Mast cells (MCs) are engaged in host defense against various pathogens as they are equipped with pattern recognition receptors (PRRs). Among PRRs expressed on MCs, there are also molecules recognizing components of the fungal cell wall, which are able to induce cellular activation and response. However, little information is available concerning the MC activation by various fungal-derived components. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104079DOI Listing

Immune imaging: Seeing the immune system in a new light.

Authors:
Lai Guan Ng

Cell Immunol 2020 Apr 20;350:104067. Epub 2020 Feb 20.

SIgN (Singapore Immunology Network), 8A, Biomedical Grove, #3 Immunos, Biopolis, Singapore 138648, Singapore. Electronic address:

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B7-H3: A promising therapeutic target for autoimmune diseases.

Cell Immunol 2020 Jun 21;352:104077. Epub 2020 Feb 21.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address:

B7-H3 as a newly identified costimulatory molecule that belongs to B7 ligand family, is broadly expressed in both lymphoid and non-lymphoid tissues. The overexpression of B7-H3 has been verified to be correlated with the poor prognosis and poor clinical outcome of several human cancers. In recent years, researchers reveal that B7-H3 is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS), ankylosing spondylitis (AS), etc. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104077DOI Listing

Inclusion of Dap10 or 4-1BB costimulation domains in the chPD1 receptor enhances anti-tumor efficacy of T cells in murine models of lymphoma and melanoma.

Cell Immunol 2020 May 20;351:104069. Epub 2020 Feb 20.

Department of Biological and Environmental Sciences, Longwood University, Farmville, VA, USA. Electronic address:

Chimeric antigen receptors (CAR) utilize costimulatory domains to enhance anti-tumor efficacy. However, it is unclear which costimulatory domain is preferable. Therefore, the intracellular domains of CD28, Dap10, 41BB, GITR, ICOS, or OX40 were compared in a murine chimeric PD1 (chPD1) receptor that targets tumor-associated PD1 ligands. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104069DOI Listing

Inhibition of E protein activity facilitates the quiescence exit of naïve CD4 T cells through modulating PI3K-AKT signaling and TCR microcluster formation.

Cell Immunol 2020 May 11;351:104065. Epub 2020 Feb 11.

Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China; Institute of Biological Sciences, Jinzhou Medical University, Jinzhou, Liaoning, China. Electronic address:

Many aspects remain elusive of the mechanisms governing T cell quiescence. Here we show that E protein activity helps to establish a quiescent program in naïve T cells. Decreased E protein activity, as the consequence of enforced expression of an Id1 transgene, led to the accumulation of CD4CD44 T cells. Read More

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May 2020
1.924 Impact Factor

CCR5 attenuates neutrophilic airway inflammation exacerbated by infection with rhinovirus.

Cell Immunol 2020 May 19;351:104066. Epub 2020 Feb 19.

College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University, Iksan 54596, Republic of Korea. Electronic address:

Human rhinovirus (hRV) is the most common cause of asthma exacerbation characterized by clinical and pathophysiological heterogeneity. Steroid-sensitive, Th2 type-eosinophilic asthma has been somewhat studied, but hRV-induced neutrophilic asthma exacerbation is poorly understood. Here, CCR5 was found to play a role in attenuating neutrophilic airway inflammation in hRV-induced asthma exacerbation using chicken ovalbumin (OVA)-based model. Read More

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http://dx.doi.org/10.1016/j.cellimm.2020.104066DOI Listing
May 2020
1.924 Impact Factor