8,559 results match your criteria Cellular And Molecular Biology[Journal]


Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.

Histol Histopathol 2020 Jul 7:18238. Epub 2020 Jul 7.

Department of Anatomy, Histology and Neuroscience, School of Medicine, Autonoma University of Madrid, Madrid. Spain.

The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration. It is derived from the proepicardium (PE), groups of cells that emerges at early developmental stages from the dorsal pericardial layer (DP) close to the atrio-ventricular canal and the venous pole of the heart-tube. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14670/HH-18-238DOI Listing

Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):250-263. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Prostate cancer is an international health problem and represents one of the most encountered malignancies among men. In this complex and heterogeneous disease, androgens and their receptors play a crucial role in both progression and development. Although the search for its effective treatment is still ongoing, among other priorities it requires developing better anticancer agents with greater efficacy and fewer side effects. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Plant-food-derived bioactives: Key health benefits and current nanosystems as a strategy to enhance their bioavailability.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):232-242. Epub 2020 Jun 25.

Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

Natural products interest is gradually increasing worldwide. Plant-food-derived bioactives have a long history of use as a good source of ingredients for valuable medical usages. Plant-based foods consist of micro and macronutrients, and bioactive components, with health-promoting benefits. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Xanthan gum in drug release.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):199-207. Epub 2020 Jun 25.

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.

Controlled release is of vital relevance for many drugs; thus, there is a keen interest in materials that can improve the release profiles of formulations administered via buccal, transdermal, ophthalmic, vaginal, and nasal. The desirable effects of those materials include the improvement of stability, adhesiveness, solubility, and retention time. Hence, different synthetic and natural polymers are utilized to achieve these objectives. Read More

View Article

Download full-text PDF

Source

Hyaluronic acid in wound dressings.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):191-198. Epub 2020 Jun 25.

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.

Human skin possesses an essential function in the maintenance of individuals' health. However, it may undergo a variety of lesions that produce wounds of distinct severity. In this respect, instantly after any skin wound, the process of tissue regeneration and repair initiates. Read More

View Article

Download full-text PDF

Source

Jerusalem artichoke (Helianthus tuberosus L.) as a medicinal plant and its natural products.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):160-177. Epub 2020 Jun 25.

Department of Plant Production and Food Safety, Stanislaw Pigonia State Higher Vocational School in Krosno, Dmochowskiego 12 str., 38-400 Krosno, Poland.

Identifying the nutritional and health properties of Helianthus tuberosus, and learning more about this valuable species. It is believed that increased consumption of Jerusalem artichoke (JA) products is related to low blood pressure. One of many questions to answer is whether supplementation of inulin and inulin derivatives obtained from Helianthus tuberosus tubers and aerial parts can be used as antidiabetic, anti-carcinogenic, anti-fungistatic, anti-constipation, body mass-reducing, metabolism-improving agents. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Anti-proliferative, genotoxic and cytotoxic effects of phytochemicals isolated from Anatolian medicinal plants.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):145-159. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The potential of natural products in cancer prevention and treatment has received worldwide interest in recent years from the nutraceutical and pharmaceutical industry point of view. Medicinal plants have been traditionally used as they exhibit a wide range of therapeutic effects due to their phytoconstituents which play an active role against oxidative stress-associated diseases such as cancer. They may block or suppress multistage carcinogenesis mainly through mechanistic regulation of the myriad of deregulated cellular pathways. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):133-144. Epub 2020 Jun 25.

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, Serbia.

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin present in a variety of plant species. Resveratrol has a wide spectrum of pharmacologic properties, and it exhibits versatile biological effects on different human and animal models. The studies have shown that potassium (K) channels can be potential targets in the mechanism of resveratrol action. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Phenolic compounds, saponins and alkaloids on cancer progression: emphasis on p53 expression and telomere length.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):110-119. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Telomere length is correlated with cell proliferation, and cancer cells are characterized by an uncontrolled cell cycle. Being apoptosis one of the checks and balances incorporated into cells cycle, due to its characteristics, cancer cells are able to overcome this process. In particular, the tumour suppressor protein p53 loss or inactivation can lead to activation of telomerase enzyme, which can make cells unable to detect DNA damages that spurs apoptosis. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):78-103. Epub 2020 Jun 25.

Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, P.O. Box 24144, Qatar.

The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Herbal remedies as alternative to conventional therapies for the treatment of pediatric infectious diseases.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):45-53. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pediatric infections still represent a leading cause of mortality in many developing countries. Since ancient times, traditional healing systems provided some herbal remedies to treat pediatric diseases, only in some cases validated by an evidence-based approach. Therefore, this review covers the herbal remedies in Iranian traditional medicine and aims to assess the potential of phytotherapeutics as safe and effective alternatives to conventional therapies for the treatment of pediatric infectious diseases. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Biological activities of sinularin: A literature-based review.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):33-36. Epub 2020 Jun 25.

Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10-748 Olsztyn, Poland.

Sinularin ((9E)-13-hydroxy-4,9,13-trimethyl-17-methylidene-5,15-dioxatricyclo[12.3.1. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

p-Cymene metallo-derivatives: An overview on anticancer activity.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):28-32. Epub 2020 Jun 25.

Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10-748 Olsztyn, Poland.

Metallo-drugs have gained a huge attention among scientific community in the couple years. These drugs types have become important compounds in cancer therapy, where, for instance, platinum complexes are being used against many tumors worldwide. Nonetheless, to p-cymene metallo-derivatives a promising anticancer potential has also been increasingly proposed. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Biological activities and health-promoting effects of Pyracantha genus: a key approach to the phytochemical's potential.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):20-27. Epub 2020 Jun 25.

Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

Pyracantha spp. are commonly called firethorn, and attract human attention due to their colorful berries. These berries are eaten globally as a traditional remedy for treating different stomach abnormalities, and as a cooking ingredient for folk diets. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Phytochemical screening of Alstonia scholaris leaf and bark extracts and their antimicrobial activities.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):270-279. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Alstonia sholaris is an evergreen tree commonly found in South East Asia. In traditional medicine pharmacological activities are attributed to the leaves and bark of this plant. The aim of this study is characterizing the chemicals present in A. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Phytol anti-inflammatory activity: Pre-clinical assessment and possible mechanism of action elucidation.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):264-269. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Phytol (PHY) is an acyclic natural diterpene alcohol and a chlorophyll constituent that exhibits several pharmacological effects, such as anticancer, antioxidant, and antimicrobial. Here, we aimed to assess the PHY anti-inflammatory effect in vitro and in vivo, and to deepen knowledge on the possible mechanism of action. For this purpose, egg albumin (in vitro) test was performed by using acetyl salicylic acid (ASA) as a standard nonsteroidal anti-inflammatory drugs (NSAID). Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):243-249. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Phytol (PHY), a chlorophyll-derived diterpenoid, exhibits numerous pharmacological properties, including antioxidant, antimicrobial, and anticancer activities. This study evaluates the anti-diarrheal effect of phytol (PHY) along with its possible mechanism of action through in-vivo and in-silico models. The effect of PHY was investigated on castor oil-induced diarrhea in Swiss mice by using prazosin, propranolol, loperamide, and nifedipine as standards with or without PHY. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Phytochemical screening of Alstonia venenata leaf and bark extracts and their antimicrobial activities.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):224-231. Epub 2020 Jun 25.

Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10-748 Olsztyn, Poland.

Alstonia venenata is a plant commonly found in South India and used in traditional medicine. The aim of this study was to characterize the phytochemicals present in A. venenata leaf and bark extracts and study their antimicrobial activities. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Synergistic antimicrobial action and effect of active chitosan-gelatin biopolymeric films containing Thymus vulgaris, Ocimum basilicum and Origanum majorana essential oils against Escherichia coli and Staphylococcus aureus.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):214-223. Epub 2020 Jun 25.

School of Food Engineering, University of Campinas. Zip code: 13083-862, Campinas, Sao Paulo, Brazil.

To replace synthetic preservatives and expand green consumption, several essential oils have been tested in foods and food packaging due to their antimicrobial properties. This study aimed to analyze the synergistic antimicrobial action of a chitosan-gelatin based active biopolymers with the addition of essential oils (EOs). The antimicrobial agents were tested against foodborne microorganisms Staphylococcus aureus and Escherichia coli strains. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Nephroprotective effects of Datura metel extract in gentamicin induced mice model: biochemical and histological evidences.

Cell Mol Biol (Noisy-le-grand) 2020 06 25;66(4):208-213. Epub 2020 Jun 25.

Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Pakistan.

Datura metel is traditionally used as a remedy for renal toxicity. However, the nephroprotection has not been scientifically validated yet. To evaluate the nephroprotective like effect of methanolic extract of D. Read More

View Article

Download full-text PDF

Source

Preventive therapy of antioxidant vitamins against the blood choline levels in cardiovascular patients.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):184-190. Epub 2020 Jun 25.

Department of Food Sciences, Faculty of Bioscience, Cholistan University of Veterinary & Animal Sciences, Bahawalpur, Pakistan.

Therapeutic role of antioxidant against lipid profile and lipoprotein (choline) was observed by the different researchers, but  clinical evidences required about the use of antioxidant vitamins against the lipoproteins. Patients with clinical evidence of cardiovascular disease (CVD) confirmed by standard diagnostic techniques were followed. Newly or recently, diagnosed case subjects were recruited wherever possible. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Association of life style and dietary habits with blood choline and cardiovascular outcome.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):178-183. Epub 2020 Jun 25.

Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius.

Whole-blood choline, plasma choline and serum choline are emerging biomarkers in cardiovascular diseases (CVD). To examine the association of Whole-blood choline is an early predictor for cardiac events. In case control study, we enrolled 240 individuals including 120 normal (39 females and 82 males) and 120 cases (49 females and 71 males) where age limit was >40 years) Information through interviews, family disease history, 24 recall diet assessment and blood sampling. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Phytochemical characterization of the Ziziphus joazeiro Mart. metabolites by UPLC-QTOF and antifungal activity evaluation.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):127-132. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The aim of this study was to evaluate the antifungal and modulatory potential of the Ziziphus joazeiro bark and leaf extracts, both in isolation and in association with fluconazole, against resistant species from the Candida genus. Antifungal assays were used to determine the half maximal inhibitory concentration (IC50) of the extract in isolation and in combination with fluconazole using the broth microdilution method and spectrophotometric readings, followed by verification of the minimum fungicidal concentration by solid medium subculture. According to the cell viability curve, both extracts inhibited fungal growth in a concentration dependent manner, in addition to showing inhibitory concentrations similar to fluconazole. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Antitumor effects of citrinin in an animal model of Sarcoma 180 via cytogenetic mechanisms.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):120-126. Epub 2020 Jun 25.

Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - UFPI, Teresina, Piauí, 64.049-550, Brazil.

Citrinin (CIT) is a cytotoxic, hepatotoxic, nephrotoxic and cardiotoxic metabolite obtained from Penicillium citrinum, that has been increasingly searched as an anticancer drug candidate. In this study, we assessed the antitumor effects of citrinin, using cytogenetic biomarkers for genotoxicity in Sarcoma 180 (S-180) ascitic fluid cells of mice. Citrinin, extracted from P. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Untargeted profiling of field cultivated bush tea (Athrixia phylicoides DC.) based on metabolite analysis.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):104-109. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Bush tea (Athrixia phylicoides DC.) is an aromatic South African indigenous plant used for many decades as a health beverage and medicine. Several studies have extensively investigated wild bush tea's secondary metabolites, but the entire profiling of cultivated bush tea's metabolites is limited in the literature. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Anxiolytic-like effects of Moringa oleifera in Swiss mice.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):73-77. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Moringa oleifera is evident to act against many neurological diseases, including muscle spasm, epilepsy, nervousness, fatigue, memory impairment, convulsion, and epilepsy. Anxiety represents the most common and disabling psychiatric condition, being often associated with depressive symptoms. This study investigated the anxiolytic-like effects of crude organic fractions of M. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Bio-therapeutics effects of probiotic strain on the gastrointestinal health of severely acute malnourished children.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):65-72. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.

The core objective was to evaluate the effect of probiotic fortification at three phases of formula milk administration in malnourished children. A dose related effect was determined in 30 severely acute malnourished children (6-59 months) in a double-blind, randomized design. According to the results, serum albumin levels, treatment T2 (6 billion cfu) has significantly increased albumin levels (3. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Modulatory-antibiotic activity of the essential oil from Eucalyptus citriodora against MDR bacterial strains.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):60-64. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The growing number of bacterial strains resistant to therapeutic agents has been surpassing the various antibiotics developed by the chemical and pharmaceutical industries. This problem has driven the development of research using agents with antimicrobial potential, with an emphasis on plant-derived natural products. This study evaluated the chemical compounds present in Eucalyptus citriodora essential oil (EOEc) cultivated in northeastern Brazil and its properties as an antibacterial agent and resistance modifier against methicillin-resistant Staphylococcus aureus (MRSA) and β-lactamase-producing strains. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):54-59. Epub 2020 Jun 25.

Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina (Piauí)- 64.049-550, Brazil.

There is evidence that palmatine (PA), an alkaloid isolated from the Guatteria friesiana plant, has some important biological activities, including anti-inflammatory and antidepressant effects. In this study, the antioxidant and anti-acetylcholinesterase (AChE) effects of PA were assessed. The antioxidant capacity was evaluated in vitro and in vivo through 7 distinct assays, and the anti-AChE activity was determined in vitro. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Effects of galacto-oligosaccharide prebiotics in blood profile of severely acute malnourished children.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):37-44. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.

This study assessed the effects of galacto-oligosaccharides (Oligomate) on hematocrit, serum enzymes, total bilirubin levels, and serum electrolytes in controls and severely malnourished infants, with emphasis on gastrointestinal symptoms. Oligomate doses and phases did not affect stools frequency per day, indicating that prebiotic effect on stool may be due to the prebiotic type. The number of vomits per day during phases 2 and 3 were significantly reduced (p<0. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Ascorbic acid antagonizes the sedative effect of diazepam possibly through inhibition of GABA(Aρ₁) and GABA(B1) receptors.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):15-19. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Gamma-aminobutyric acid (GABA) receptors belong to a ligand-gated ion channels family and are markedly expressed at the axon terminals of retinal bipolar cells. Ascorbic acid (AA), a known and vital antioxidant in the brain can modulate GABA receptors. We postulate that AA would antagonize benzodiazepines' effect via GABA receptor(s) interacting pathway. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

High-performance thin-layer chromatography fingerprinting, total phenolic and total flavonoid contents and anti-platelet-aggregation activities of Prosopis farcta extracts.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):8-14. Epub 2020 Jun 25.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cardiovascular diseases are a leading cause of worldwide death and excessive platelet is closely related with their pathogenesis. Different plants and natural compounds have demonstrated anti-platelet effects. The aim of this study was to report the high-performance thin-layer chromatography (HPTLC) fingerprinting and anti-platelet-aggregation activities of different leaf extracts (n-hexane, chloroform, ethyl acetate, methanol and aqueous) of Prosopis farcta (Syrian mesquite) plant. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Vitex negundo Linn.: phytochemical composition, nutritional analysis, and antioxidant and antimicrobial activity.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):1-7. Epub 2020 Jun 25.

Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran.

Vitex negundo (VN) is a widely used plant in folk medicine, namely for the treatment of jaundice, wounds, body ache, toothache, asthma, eye pain, and migraine. These effects have been increasingly attributed to its chemical composition. Here, we assessed the VN chemical and nutritional composition and biological activity, with particular emphasis on antioxidant and antimicrobial effects. Read More

View Article

Download full-text PDF

Source
June 2020
1.234 Impact Factor

Histone deacetylase 6 inhibitor ACY1215 ameliorates mitochondrial dynamic and function injury in hepatocytes by activating AMPK signaling pathway in acute liver failure mice.

Histol Histopathol 2020 Jun 23:18237. Epub 2020 Jun 23.

Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

Acute liver failure (ALF) is often accompanied by dynamic and functional disorders of mitochondria in hepatocytes. The histone deacetylase 6 inhibitor Rocilinostat (ACY1215) has a hepatoprotective effect. However, its protective effect on mitochondria of hepatocytes and its related mechanisms in ALF remain unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14670/HH-18-237DOI Listing

Cadherins down-regulation: towards a better understanding of their relevance in colorectal cancer.

Histol Histopathol 2020 Jun 22:18236. Epub 2020 Jun 22.

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

The down-regulation of cadherin expression in colorectal cancer (CRC) has been widely studied. However, existing data on cadherin expression are highly variable and its relevance to CRC development has not been completely established. This review examines published studies on cadherins whose down-regulation has been already demonstrated in CRC, trying to establish a relationship with promoter methylation, the capacity to influence the Wnt / CTNNB1 (catenin beta 1, beta-catenin) signalling pathway and the clinical implications for disease outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14670/HH-18-236DOI Listing

Angiopoietin-1 is associated with a decreased risk of lymph node metastasis in early stage cervical cancer.

Histol Histopathol 2020 Jun 17:18234. Epub 2020 Jun 17.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.

Objectives: Lymph node metastasis (LNM) is an important determinant of prognosis in patients with cervical cancer. Members of the angiopoietin family have been demonstrated to regulate tumor-associated angiogenesis and lymphangiogenesis. This study aimed to investigate the expression levels of angiopoietin-1 (ANG1) and angiopoietin-2 (ANG2) in clinically early stage of cervical cancer along with their correlations with LNM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14670/HH-18-234DOI Listing

Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.

Histol Histopathol 2020 Jun 18:18235. Epub 2020 Jun 18.

Department of Geriatric Medicine, Tokyo Medical University, Nishishinjuku, Shinjuku-ku, Tokyo, Japan.

The transactivation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein pivotal in RNA processing. Because phosphorylated TDP43 (pTDP-43) has been identified as a component of the ubiquitin-positive and tau-negative inclusions observed in the brains of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients, it is considered to play a major role in neurodegenerative processes. We previously reported that pTDP-43 is located in macrophages of atherosclerotic lesions of human carotid and major cerebral arteries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14670/HH-18-235DOI Listing

Current knowledge of pituitary adenylate cyclase activating polypeptide (PACAP) in articular cartilage.

Histol Histopathol 2020 Jun 16:18233. Epub 2020 Jun 16.

Department of Biomedical and Biotechnological Sciences, Anatomy, Histology and Movement Sciences Section, School of Medicine, University of Catania, Catania, Italy.

Pituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionally well conserved neuropeptide, mainly expressed by neuronal and peripheral cells. It proves to be an interesting object of study both for its trophic functions during the development of several tissues and for its protective effects against oxidative stress, hypoxia, inflammation and apoptosis in different degenerative diseases. This brief review summarises the recent findings concerning the role of PACAP in the articular cartilage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14670/HH-18-233DOI Listing
June 2020
2.096 Impact Factor

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future objectives.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):211-214. Epub 2020 Jun 5.

Laboratoire Denel-Codifra, Le Chesnay, France.

The objective of this communication is to present and analyze the recent results from the LAPIBSS study in order to improve future clinical trials on the effects of Lactobacillus strains in the treatment of irritable bowel syndrome (IBS). Using a tightly-controlled clinical trial protocol with the highest Jadad score of 5/5, the current trial aimed to demonstrate the efficacy of a 2-strain mixture of Lactobacillus acidophilus (L. acidophilus) to improve IBS symptoms. Read More

View Article

Download full-text PDF

Source

Combating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):221-229. Epub 2020 Jun 5.

Department of Internal Medicine Firat University School of Medicine, Elazig, Turkey.

It can be misleading to think that the new severe acute respiratory syndrome coronavirus (SARS-CoV2) which has a very strong mutation and adaptation capabilities, uses only the angiotensin-converting enzyme II (ACE2) pathway to reach target cells. Despite all the precautions taken, the pandemic attack continues and the rapid increase in the number of deaths suggest that this virus has entered the cell through different pathways and caused damage through different mechanisms. The main reason why the ACE2 pathway comes to the fore in all scientific studies is that this receptor is located at the entry point of basic mechanisms that provide alveolo-capillary homeostasis. Read More

View Article

Download full-text PDF

Source

TRAIL mediated signaling as a double-edged sword in pancreatic cancer: Analysis of brighter and darker sides of the pathway.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):215-220. Epub 2020 Jun 5.

Ministry of Health of the Republic of Kazakhstan. Zhibek zholy 5, Almaty, Kazakhstan.

Genetic, genomic and proteomic studies have refined our concepts related to underlying mechanisms of pancreatic cancer. Increasingly sophisticated knowledge has started to shed light on the fact that pancreatic cancer harbored multiple epigenetic and genetic alterations and revealed complicated and dense tumor microenvironments. Our rapidly evolving knowledge about pancreatic cancer has helped us in identification of myriad of underlying mechanisms which play instrumental role in disease onset, drug resistance and epithelial to mesenchymal transition (EMT). Read More

View Article

Download full-text PDF

Source

Genetic biomarkers: Potential roles in cancer diagnosis.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):1-7. Epub 2020 Jun 5.

Department of Biology, Gaziantep University, Gaziantep, Turkey.

Biomarkers are indicators of pathogenic processes, typical biological processes, or pharmacological reactions to a therapy. It has several potential usages in cancer; differential diagnosis, prognosis, risk assessment, therapeutic response, and monitoring of disease progression. Recently, advances in oncomarkers raised significant opportunities for enhancing management of cancer. Read More

View Article

Download full-text PDF

Source

Construction of SIRT1 gene shRNA lentivirus vector and its effect on the proliferation of breast cancer cells.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):204-210. Epub 2020 Jun 5.

Department of Thyroid and Breast Surgery, Jingmen No. 2 People's Hospital, Jingmen 448000, Hubei Province, China.

Current experiment aimed to investigate the construction of the SIRT1 gene shRNA lentivirus vector and its effect on proliferation of breast cancer cells. Altogether 80 cases of breast cancer tissues and 80 cases of normal adjacent tissues were collected. qPCR was used for detecting SIRT1 expression. Read More

View Article

Download full-text PDF

Source

Evaluation of some cellular biomarker proteins, oxidative stress and clinical indices as results of laparoscopic appendectomy for perforated appendicitis in children.

Authors:
Qiang Liu Ke Xu

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):197-203. Epub 2020 Jun 5.

Pediatric Surgery, Baoji Maternal and Child Health care Hospital of Shaanxi Province, Baoji, 721000, China.

Laparoscopic appendectomy for perforated appendicitis in children has the advantages of quick recovery, little influence of inflammatory and oxidative stress and low infection rate. Altogether 115 children with perforated appendicitis treated in our hospital from June 2018 to August 2019 were selected and divided into two groups according to different treatment methods. Laparoscopic appendectomy was used as the research group (RG) (67 cases) and open appendectomy (48 cases) as the control group (CG). Read More

View Article

Download full-text PDF

Source

Effect of lncRNA KCNQ1OT1 on autophagy and drug resistance of hepatocellular carcinoma cells by targeting miR-338-3p.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):191-196. Epub 2020 Jun 5.

Psychiatry Department, Jingmen No.2 People's Hospital, Jingmen, 448000, China.

The current experiment aimed to investigate the effects of lncRNA KCNQ1OT1 on the proliferation, autophagy and drug resistance of hepatocellular carcinoma cells, as well as the potential molecular mechanism. Hepatocellular carcinoma SK-HEP-1 cells and DDP resistant SK-HEP-1/DDP cells were treated with cisplatin (DDP) of different concentrations (1 nmol/L, 2 nmol/L, 4 nmol/L, 8 nmol/L, 16 nmol/L). The survival rate of SK-HEP-1 and SK-HEP-1/DDP cells was determined by the CCK8 method. Read More

View Article

Download full-text PDF

Source

Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):185-190. Epub 2020 Jun 5.

The Skin Department, Weifang Traditional Chinese Hospital, Weifang, 261041, China.

The current experiment was performed to investigate whether luteolin affects the proliferation and apoptosis of keloid fibroblasts by regulating the expression of FRAT1 gene. Keloid fibroblasts were treated with luteolin at different concentrations. MTT method, western blot, flow cytometry, and real-time quantitative PCR (qPCR) were used to detect cell proliferation, cyclin D1 (CyclinD1), p21, B-cell lymphoma / leukemia-2 (Bcl-2), Bcl-2 related X protein (Bax), FRAT1 protein expression, apoptosis and ARHI mRNA expression. Read More

View Article

Download full-text PDF

Source

Piceatannol inhibits proliferation and induces apoptosis of bladder cancer cells through regulation of the PTEN/AKT signal pathway.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):181-184. Epub 2020 Jun 5.

Department of Urologic Surgery, The First People's Hospital of Jiu Jiang City of Jiang Xi Province, Jiu Jiang Hospital Affiliated Medical School of Nanchang University, Jiu Jiang City, Jiang Xi Province 332000, China.

This study was aimed to investigate the effect of piceatannol (PIC) on the proliferation and apoptosis of bladder cancer cell line EJ, and the underlying mechanism.   Bladder cancer cell line EJ was incubated with different concentrations of PIC, and CCK-8 method was used to determine the effect of the treatment on cell proliferation. The effect of PIC on cell cycle, apoptosis and the expressions of related signal pathway proteins were determined using Western blotting. Read More

View Article

Download full-text PDF

Source

Nitric oxide donor andrographolide enhances humoral and cell-mediated immune responses.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):176-180. Epub 2020 Jun 5.

Department of Clinical Lab, The Central Hospital of Nanchong, Nanchong, PR China.

The present study was aimed to investigate the regulatory effect of Nitric oxide  donor andrographolide (Q-1) on cellular immunity in patients with chronic hepatitis B. Peripheral blood mononuclear cells (PBMCs) were isolated from patients with chronic hepatitis B. Cell viability was assessed using 3‑(4,5‑dimethyl‑thiazol‑2‑yl)‑2,5‑diphenyl‑2H‑tetrazolium bromide (MTT) assay. Read More

View Article

Download full-text PDF

Source

Analgesic action of Rubimaillin in vitro and in vivo.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):171-175. Epub 2020 Jun 5.

Department of Rehabilitation, Yantai Hospital of Traditional Chinese Medicine, Yantai, PR China.

Pain, a common symptom in clinics, is a serious impediment to quality of life. The analgesic drugs presently in use have poor efficacy, and are associated with undesirable side effects. Rubimaillin (Rub) is a naphthoquinone compound extracted from Chinese herbal medicine, and it has various biological activities. Read More

View Article

Download full-text PDF

Source

Electroacupuncture ameliorates post-traumatic stress disorder in rats via a mechanism involving the BDNF-TrkB signaling pathway.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):165-170. Epub 2020 Jun 5.

Chinese medicine College, Hainan Medical University, No.3, Xueyuan Road, Longhua District, Haikou City, Hainan Province, China.

Post-traumatic stress disorder (PTSD) is a mental health condition triggered by a terrifying event, causing flashbacks, nightmares and severe anxiety. It develops in individuals who have experienced a shocking, scary, or dangerous event. Electroacupuncture is reported to be effective for the treatment of PTSD. Read More

View Article

Download full-text PDF

Source