1,357 results match your criteria Cells tissues organs[Journal]


Ameliorative Effect of Cardamom Aqueous Extract on Doxorubicin-Induced Cardiotoxicity in Rats.

Cells Tissues Organs 2019 Feb 4:1-11. Epub 2019 Feb 4.

Department of Anatomy, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El Sheikh,

This study was conducted to evaluate the potential cardioprotective effect of cardamom (CAR) against myocardial injuries induced by doxorubicin (DOX) in rats through investigation of histological alterations and the associated oxidative stress, apoptosis, inflammation, and angiogenesis. This study included 30 adult male albino rats that were randomized to 3 groups (n = 10/group): group I (control), group II (DOX) rats injected with DOX (2.5 mg/kg body weight [BW] i. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/496109
Publisher Site
http://dx.doi.org/10.1159/000496109DOI Listing
February 2019
8 Reads

The Effect of the Prethanol Extract of Trifolium pratense Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes.

Cells Tissues Organs 2019 Jan 31:1-11. Epub 2019 Jan 31.

Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju, Republic of

Background: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a crucial role in the pathogenesis of OA by inducing the release of other catabolic factors that contribute to cartilage degradation. Trifolium pratense L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496108DOI Listing
January 2019
1 Read

The Effect of Adenosine on Extracellular Matrix Production in Porcine Intervertebral Disc Cells.

Cells Tissues Organs 2019 Jan 31:1-9. Epub 2019 Jan 31.

Department of Biomedical Engineering, University of Miami, Coral Gables, Florida,

Compressive loading promotes adenosine triphosphate (ATP) production and release by intervertebral disc (IVD) cells. Extracellular ATP can be rapidly hydrolyzed by ectonucleotidases. Adenosine, one of the adenine derivatives of ATP hydrolysis, can modulate diverse cellular actions via adenosine receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496186DOI Listing
January 2019

A New Beginning for Cells Tissues Organs.

Cells Tissues Organs 2019 Jan 30;205(5-6):1-2. Epub 2019 Jan 30.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496633DOI Listing
January 2019

Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities.

Cells Tissues Organs 2019 Jan 24:1-12. Epub 2019 Jan 24.

Department of Molecular Biotechology, Faculty of Bioscience Engineering, Ghent University, Ghent,

Polyphenols are known for their antimicrobial activity, whilst both polyphenols and the globular protein β-lactoglobulin (bLG) are suggested to have antioxidant properties and promote cell proliferation. These are potentially useful properties for a tissue-engineered construct, though it is unknown if they are retained when both compounds are used in combination. In this study, a range of different microbes and an osteoblast-like cell line (human fetal osteoblast, hFOB) were used to assess the combined effect of: (1) green tea extract (GTE), rich in the polyphenol epigallocatechin gallate (EGCG), and (2) whey protein isolate (WPI), rich in bLG. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494732
Publisher Site
http://dx.doi.org/10.1159/000494732DOI Listing
January 2019
3 Reads

Two Web Resources Linking Major Human Embryology Collections Worldwide.

Authors:
Mark A Hill

Cells Tissues Organs 2019 Jan 23:1-10. Epub 2019 Jan 23.

Anatomy, School of Medical Sciences, UNSW Sydney, Sydney, New South Wales,

Human embryology is a core subject for medicine and current research. While animal models of development now have significant online resources available, the vast majority of human embryonic material is locked up in historic collections. When accessed today, these collections are still contributing to our understanding of human development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495619DOI Listing
January 2019
1 Read

Vimentin-Induced Cardiac Mesenchymal Stem Cells Proliferate in the Acute Ischemic Myocardium.

Cells Tissues Organs 2019 Jan 10:1-11. Epub 2019 Jan 10.

Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), Rostock University Medical Center, Rostock, Germany.

In-depth knowledge of the mechanisms induced by early postischemic cardiac endogenous mesenchymal stem cells (MSCs) in the acutely ischemic heart could advance our understanding of cardiac regeneration. Herein, we aimed to identify, isolate, and initially characterize the origin, kinetics and fate of cardiac MSCs. This was facilitated by in vivo genetic cell fate mapping through green fluorescent protein (GFP) expression under the control of vimentin induction after acute myocardial infarction (MI). Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495527
Publisher Site
http://dx.doi.org/10.1159/000495527DOI Listing
January 2019
6 Reads
2.137 Impact Factor

A Perfused Microfluidic System to Study the Differentiation of Neural Stem Cells in vitro.

Cells Tissues Organs 2018 Dec 21:1-8. Epub 2018 Dec 21.

College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.

Introduction: Due to the ability to mimic in vivo cellular microenvironments, the development of multicell culture systems has received increasing interest for use as research models and serving as platforms for drug evaluation.

Methods: In this study, we developed a perfused microfluidic system to resemble the in vivo intercellular environment and applied it to study the differentiation from neural stem cells into neurons.

Results: As determined by immunofluorescence chemistry and quantitative real-time PCR, the neural stem cells grown in this microfluidic system showed an elevated differentiation rate toward the formation of neurons as determined by the increased level of βIII-tubulin production, which is 4 times higher than that of culturing neural stem cells only. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/495219
Publisher Site
http://dx.doi.org/10.1159/000495219DOI Listing
December 2018
7 Reads

The Chick Caudolateral Epiblast Acts as a Permissive Niche for Generating Neuromesodermal Progenitor Behaviours.

Cells Tissues Organs 2018 Dec 5:1-11. Epub 2018 Dec 5.

Department of Genetics, University of Cambridge, Cambridge, United

Neuromesodermal progenitors (NMps) are a population of bipotent progenitors that maintain competence to generate both spinal cord and paraxial mesoderm throughout the elongation of the posterior body axis. Recent studies have generated populations of NMp-like cells in culture, which have been shown to differentiate to both neural and mesodermal cell fates when transplanted into either mouse or chick embryos. Here, we aim to compare the potential of mouse embryonic stem (ES) cell-derived progenitor populations to generate NMp behaviour against both undifferentiated and differentiated populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494769DOI Listing
December 2018
4 Reads

Biomaterial Approaches to Modulate Reactive Astroglial Response.

Cells Tissues Organs 2018 Dec 5:1-24. Epub 2018 Dec 5.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York,

Over several decades, biomaterial scientists have developed materials to spur axonal regeneration and limit secondary injury and tested these materials within preclinical animal models. Rarely, though, are astrocytes examined comprehensively when biomaterials are placed into the injury site. Astrocytes support neuronal function in the central nervous system. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494667
Publisher Site
http://dx.doi.org/10.1159/000494667DOI Listing
December 2018
4 Reads

On the Enigma of the Human Neurenteric Canal.

Cells Tissues Organs 2018 Nov 27:1-23. Epub 2018 Nov 27.

Institute of Anatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany.

Existence and biomedical relevance of the neurenteric canal, a transient midline structure during early neurulation in the human embryo, have been controversially discussed for more than a century by embryologists and clinicians alike. In this study, the authors address the long-standing enigma by high-resolution histology and three-dimensional reconstruction using new and historic histological sections of 5 human 17- to 21-day-old embryos and of 2 marmoset monkey embryos of the species Callithrix jacchus at corresponding stages. The neurenteric canal presents itself as the classical vertical connection between the amniotic cavity and the yolk sac cavity and is lined (a) craniolaterally by a horseshoe-shaped "hinge of involuting notochordal cells" within Hensen's node and (b) caudally by the receding primitive streak epiblast dorsally and by notochordal plate epithelium ventrally, the latter of which covered the (longitudinal) notochordal canal on its ventral side at the preceding stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000493276DOI Listing
November 2018
3 Reads

Growing Human Parathyroids in a Microphysiological System: A Novel Approach to Understanding and Developing New Treatments for Hyperparathyroidism.

Cells Tissues Organs 2018 Nov 22:1-8. Epub 2018 Nov 22.

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

We developed a novel model for studying hyperparathyroidism by growing ex vivo 3-dimensional human parathyroids as part of a microphysiological system (MPS) that mimics human physiology. The purpose of this study was to validate the parathyroid portion of the MPS. We prospectively collected parathyroid tissue from 46 patients with hyperparathyroidism for growth into pseudoglands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494571DOI Listing
November 2018
6 Reads

Advances and Current Challenges Associated with the Use of Human Induced Pluripotent Stem Cells in Modeling Neurodegenerative Disease.

Cells Tissues Organs 2018 Oct 9:1-19. Epub 2018 Oct 9.

Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA.

One of the most profound advances in the last decade of biomedical research has been the development of human induced pluripotent stem cell (hiPSC) models for identification of disease mechanisms and drug discovery. Human iPSC technology has the capacity to revolutionize healthcare and the realization of personalized medicine, but differentiated tissues derived from stem cells come with major criticisms compared to native tissue, including variability in genetic backgrounds, a lack of functional maturity, and differences in epigenetic profiles. It is widely believed that increasing complexity will lead to improved clinical relevance, so methods are being developed that go from a single cell type to various levels of 2-D coculturing and 3-D organoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000493018DOI Listing
October 2018
4 Reads

Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia.

Cells Tissues Organs 2018 Oct 9:1-14. Epub 2018 Oct 9.

Genetics, Genomics and Development Division, Molecular and Cell Biology Department, University of California, Berkeley, California, USA.

Na+/H+ exchangers (NHEs) represent a highly conserved family of ion transporters that regulate pH homeostasis. NHEs as well as other proton transporters were previously linked to the regulation of the Wnt signaling pathway, cell polarity signaling, and mucociliary function. Furthermore, mutations in the gene SLC9A3 (encoding NHE3) were detected as additional risk factors for airway infections in cystic fibrosis patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492973DOI Listing
October 2018
5 Reads

Large Cytoplasmic Vacuoles within Notochordal Nucleus Pulposus Cells: A Possible Regulator of Intracellular Pressure That Shapes the Cytoskeleton and Controls Proliferation.

Cells Tissues Organs 2018 Oct 3:1-7. Epub 2018 Oct 3.

Department of Spine Surgery, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.

Degeneration of the intervertebral disc, which is closely associated with the loss of vacuolated notochordal nucleus pulposus cells (NNPC), remains a major cause of lower-back pain and motor deficiency. Being the most defining characteristic of NNPC, large cytoplasmic vacuoles not only modulate the cytoskeleton and shape cell morphology but they also respond to the disc microenvironment and regulate the biological behavior of vacuolated cells as a potent reporter of the histocytological changes that occur at the beginning of disc aging and degeneration. Here we hypothesize a model in which large cytoplasmic vacuoles primarily function to maintain a reasonable intracellular pressure (Pv) that facilitates NNPC in resisting the extracellular mechanical loading (Pe), part of which is absorbed by the extracellular matrix (Pm), forming the equation Pe = Pm + Pv. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000493258DOI Listing
October 2018
2 Reads

Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering.

Cells Tissues Organs 2018 Oct 1:1-22. Epub 2018 Oct 1.

Oxygen is a vital source of energy necessary to sustain and complete embryonic development. Not only is oxygen the driving force for many cellular functions and metabolism, but it is also involved in regulating stem cell fate, morphogenesis, and organogenesis. Low oxygen levels are the naturally preferred microenvironment for most processes during early development and mainly drive proliferation. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/493162
Publisher Site
http://dx.doi.org/10.1159/000493162DOI Listing
October 2018
3 Reads

Farewell to Hans-Werner Denker and Arthur English.

Authors:

Cells Tissues Organs 2018 Sep 28. Epub 2018 Sep 28.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491561DOI Listing
September 2018
1 Read

Goodbye & Thank You.

Cells Tissues Organs 2018 Sep 28:1-2. Epub 2018 Sep 28.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490830DOI Listing
September 2018
1 Read

Peripheral Blood Mesenchymal Stem Cells Combined with Modified Demineralized Bone Matrix Promote Pig Cartilage Defect Repair.

Cells Tissues Organs 2018 Sep 26:1-9. Epub 2018 Sep 26.

Department of Orthopaedics, The People's Hospital of WeiXin County, Zhaotong, China.

Objective: To investigate the mobilization of peripheral blood mesenchymal stem cells (PBMSCs) and whether a combination of PBMSCs and modified demineralized bone matrix (DBM) promoted the repair of cartilage lesions in a pig model.

Methods: Pig PBMSCs were mobilized by the combined administration of granulocyte colony-stimulating factor (G-CSF) and the CXCR4 antagonist AMD3100. Colony formation was detected by the fibroblast colony-forming unit (CFU-F) count and the percentage of the CD45-CD90+ cell population by flow cytometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000493210DOI Listing
September 2018
2 Reads

Comparative Analysis of Biological and Functional Properties of Bone Marrow Mesenchymal Stromal Cells Expanded in Media with Different Platelet Lysate Content.

Cells Tissues Organs 2018 17;205(4):226-239. Epub 2018 Sep 17.

Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia.

Due to their ability to induce immunological tolerance in the recipient, mesenchymal stromal cells (MSCs) have been utilized in the treatment of various hematological and immune- and inflammation-mediated diseases. The clinical application of MSCs implies prior in vitro expansion that usually includes the use of fetal bovine serum (FBS). The present study evaluated the effect of different platelet lysate (PL) media content on the biological properties of MSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492581DOI Listing
September 2018
6 Reads

Interstitial Cells in the Pineal Gland of Pregnant and Nonpregnant Viscachas (Lagostomus maximus maximus): A Morphometric and Biochemical Study.

Cells Tissues Organs 2018 13;205(4):240-250. Epub 2018 Sep 13.

Histología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.

The pineal gland of mammals undergoes morphological and biochemical changes throughout the gestation period. In viscachas, a seasonal breeding rodent, pregnancy lasts approximately 154 days and 3 stages can be defined, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492792DOI Listing
September 2018
1 Read

Optimization of Canine Placenta Decellularization: An Alternative Source of Biological Scaffolds for Regenerative Medicine.

Cells Tissues Organs 2018 10;205(4):217-225. Epub 2018 Sep 10.

Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Due to the scarcity of tissues and organs for transplantation, the demand for bioengineered tissues is increasing with the advancement of technologies and new treatments in human and animal regenerative medicine. Thus, decellularized placental extracellular matrix (ECM) has emerged as a new tool for the production of biological scaffolds for subsequent recellularization and implantation for recovery of injured areas or even for replacement of organ and tissue fractions. To be classified as an ideal biological scaffold, the ECM must be acellular and preserve its proteins and physical features to be useful for cellular adhesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492466DOI Listing
September 2018
8 Reads
2.140 Impact Factor

The Effects of Hypericum perforatum L. on the Proliferation, Osteogenic Differentiation, and Inflammatory Response of Mesenchymal Stem Cells from Different Niches.

Cells Tissues Organs 2018 17;205(4):208-216. Epub 2018 Aug 17.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

The aim of this study is to demonstrate and compare the differentiation, proliferation, migration and inflammatory behavior of dental pulp- and bone marrow-derived mesenchymal stem cells (DP-MSCs and BM-MSCs) in response to a Hypericum perforatum ethanol extract. Using xCELLigence, a real-time monitoring system, a dose of 10 µg/mL was found to be the most efficient concentration for vitality. The IC50 values and doubling time were calculated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491633DOI Listing
August 2018
3 Reads

Effects of Dexamethasone Dose and Timing on Tissue-Engineered Skeletal Muscle Units.

Cells Tissues Organs 2018 17;205(4):197-207. Epub 2018 Aug 17.

Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

Our lab showed that administration of dexamethasone (DEX) stimulated myogenesis and resulted in advanced structure in our engineered skeletal muscle units (SMU). While administration of 25 nM DEX resulted in the most advanced structure, 10 nM dosing resulted in the greatest force production. We hypothesized that administration of 25 nM DEX during the entire fabrication process was toxic to the cells and that administration of DEX at precise time points during myogenesis would result in SMU with a more advanced structure and function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490884DOI Listing
August 2018
3 Reads

Xenopus: An Undervalued Model Organism to Study and Model Human Genetic Disease.

Authors:
Martin Blum Tim Ott

Cells Tissues Organs 2018 Aug 9:1-11. Epub 2018 Aug 9.

The function of normal and defective candidate genes for human genetic diseases, which are rapidly being identified in large numbers by human geneticists and the biomedical community at large, will be best studied in relevant and predictive model organisms that allow high-speed verification, analysis of underlying developmental, cellular and molecular mechanisms, and establishment of disease models to test therapeutic options. We describe and discuss the pros and cons of the frog Xenopus, which has been extensively used to uncover developmental mechanisms in the past, but which is being underutilized as a biomedical model. We argue that Xenopus complements the more commonly used mouse and zebrafish as a time- and cost-efficient animal model to study human disease alleles and mechanisms. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/490898
Publisher Site
http://dx.doi.org/10.1159/000490898DOI Listing
August 2018
8 Reads

The Influence of Hyperosmolarity in the Intervertebral Disc on the Proliferation and Chondrogenic Differentiation of Nucleus Pulposus-Derived Mesenchymal Stem Cells.

Cells Tissues Organs 2018 31;205(3):178-188. Epub 2018 Jul 31.

Nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) are suitable cell candidates for intervertebral disc (IVD) regeneration. However, little work has been done to determine the proliferation and chondrogenic differentiation of NP-MSCs in the hyperosmotic microenvironment of IVD. This study aimed to investigate the influence of the hyperosmolarity of IVD on the proliferation and chondrogenic differ-entiation of NP-MSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490760DOI Listing
July 2018
17 Reads

The Kyoto Collection of Human Embryos and Fetuses: History and Recent Advancements in Modern Methods.

Cells Tissues Organs 2018 Jul 31:1-6. Epub 2018 Jul 31.

Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

The Kyoto Collection of Human Embryos and Fetuses, the largest collection of human embryos worldwide, was initiated in the 1960s, and the Congenital Anomaly Research Center of Kyoto University was established in 1975 for long-term storage of the collection and for the promotion of research into human embryonic and fetal development. Currently, the Kyoto Collection comprises approximately 45,000 specimens of human embryonic or fetal development and is renowned for the following unique characteristics: (1) the collection is considered to represent the total population of fetal specimens nationwide in Japan, (2) it comprises a large number of specimens with a variety of external malformations, and (3) for most specimens there are clinical and epidemiological data from the mothers and the pregnancies concerned. Therefore, the specimens have been used extensively for morphological studies and could potentially be used for epidemiological analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490672DOI Listing
July 2018
9 Reads

Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells.

Cells Tissues Organs 2018 Jul 24:1-8. Epub 2018 Jul 24.

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: A high expression of prostaglandin E2 (PGE2) is found in colorectal cancer. Therefore, blocking of PGE2 generation has been identified as a promising approach for anticancer therapy. Sulforaphane (SFN), an isothiocyanate derived from glucosinolate, is used as the antioxidant and anticancer agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490394DOI Listing
July 2018
6 Reads
1 Citation
2.140 Impact Factor

Simultaneous Study of Mechanical Stretch-Induced Cell Proliferation and Apoptosis on C2C12 Myoblasts.

Cells Tissues Organs 2018 27;205(4):189-196. Epub 2018 Jun 27.

Mechanical stretch may cause myoblasts to either proliferate or undergo apoptosis. Identifying the molecular events that switch the fate of a stretched cell from proliferation to apoptosis is practically important in the field of regenerative medicine. A recent study on vascular smooth muscle cells illustrated that identification of these events may be achieved by addressing the stretch-induced opposite cellular outcomes simultaneously within a single investigation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490239DOI Listing
June 2018
14 Reads

Comparison of Preterm and Term Wharton's Jelly-Derived Mesenchymal Stem Cell Properties in Different Oxygen Tensions.

Cells Tissues Organs 2018 27;205(3):137-150. Epub 2018 Jun 27.

Division of Neonatology MC-7812, Department of Pediatrics, University of Texas Health-San Antonio, San Antonio, Texas, USA.

Mesenchymal stem cells (MSCs) have shown promise as therapeutic agents in treating morbidities associated with premature birth. MSCs derived from the human umbilical cord are easy to isolate and have low immunogenicity and a robust ability to secrete paracrine factors. To date, there are no studies evaluating preterm versus term umbilical cord tissue-derived MSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117836PMC
June 2018
4 Reads

Distribution of Collagen I, III, and IV and Laminin in the Human Liver during Prenatal Development.

Cells Tissues Organs 2018 27;205(3):164-177. Epub 2018 Jun 27.

Department of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia.

In the absence of systematized data on the extracellular matrix components during prenatal liver development, the present study aimed to investigate the time of appearance and distribution of collagen types I, III, and IV and laminin. The study material included embryonic and fetal livers, aged 7-37 weeks, categorized into 3 trimesters. The material was stained using hematoxylin-eosin and immunohistochemistry methods for the identification of collagen I, III, and IV and laminin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489476DOI Listing
June 2018
3 Reads

Morphological Characterization of Basally Located Uninucleate Trophoblast Cells as Precursors of Bovine Binucleate Trophoblast Giant Cells.

Cells Tissues Organs 2018 20;205(3):151-163. Epub 2018 Jun 20.

Binucleate trophoblast giant cells (TGCs) are one characteristic feature of the ruminant placenta. In cows, the frequency of TGCs remains constant for most of the duration of pregnancy. As TGCs are depleted by their fusion with uterine epithelial cells, they need to be constantly formed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489257DOI Listing
June 2018
4 Reads

Grape Leucoanthocyanidin Protects Liver Tissue in Albino Rabbits with Nonalcoholic Hepatic Steatosis.

Cells Tissues Organs 2018 18;205(3):129-136. Epub 2018 Jun 18.

Medical Sciences Post Graduation Program, Fluminense Federal University, Rio de Janeiro, Brazil.

Nonalcoholic fatty liver disease (NAFLD) is a common ailment. It is usually found in association with diabetes or obesity. There are no approved drugs to treat this condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489166DOI Listing
June 2018
4 Reads

Segmentation of Dilated Hemorrhoidal Veins in Hemorrhoidal Disease.

Cells Tissues Organs 2018 18;205(2):120-128. Epub 2018 Jun 18.

Department of Cell Biology and Histology, School of Medicine, University of Murcia, Murcia, Spain.

Vein segmentation is a vascular remodeling process mainly studied in experimental conditions and linked to hemodynamic factors, with clinical implications. The aim of this work is to assess the morphologic characteristics, associated findings, and mechanisms that participate in vein segmentation in humans. To this end, we examined 156 surgically obtained cases of hemorrhoidal disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489250DOI Listing
June 2018
4 Reads

Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of Dexmedetomidine.

Cells Tissues Organs 2018 29;205(2):105-119. Epub 2018 May 29.

Department of Anesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt.

To our knowledge, this is the first study which investigates the induction of neuroinflammation in rats using an acidic-saline model of fibromyalgia. It is well known that the hippocampus has a fundamental role in pain perception, and astrocytes play a crucial role in pain signaling. Our aim is to evaluate the ability of dexmedetomidine to attenuate the inflammatory responses induced in astrocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000488757DOI Listing
May 2018
6 Reads

Decellularized Pancreas Matrix Scaffolds for Tissue Engineering Using Ductal or Arterial Catheterization.

Cells Tissues Organs 2018 9;205(2):72-84. Epub 2018 May 9.

Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cell Therapy, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Diabetes is known as a worldwide disease with a great burden on society. Since therapeutic options cover a limited number of target points, new therapeutic strategies in the field of regenerative medicine are considered. Bioscaffolds along with islet cells would provide bioengineered tissue as a substitute for β-cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487230DOI Listing
May 2018
7 Reads
2.140 Impact Factor

Innervation of the Human Incisive Papilla: Comparison with Other Oral Regions.

Cells Tissues Organs 2018 7;205(2):93-104. Epub 2018 May 7.

Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Immunohistochemistry for several neurochemical substances was performed on the human incisive papilla and other oral structures. Sodium channel alpha subunit 7 (SCN7A) protein-immunoreactive (IR) Schwann cells and protein gene product 9.5 (PGP 9. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/488278
Publisher Site
http://dx.doi.org/10.1159/000488278DOI Listing
May 2018
8 Reads

Immunolocalization of Receptor and Chemoreceptor Modules in the Sheep Vomeronasal Organ.

Authors:
Dalia Ibrahim

Cells Tissues Organs 2018 19;205(2):85-92. Epub 2018 Apr 19.

The vomeronasal organ (VNO) is the peripheral receptor organ of the accessory olfactory system, which is responsible for both sexual and innate behaviors. The degree of neuronal differentiation and maturation of the vomeronasal receptor cells together with the verification of the presence of the solitary chemoreceptor cells (SCCs) in the VNO of Corriedale sheep were assessed using immunofluorescence. A protein gene product 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487758DOI Listing
April 2018
5 Reads
2.140 Impact Factor

The Role of Epithelial Stat3 in Amelogenesis during Mouse Incisor Renewal.

Cells Tissues Organs 2018 16;205(2):63-71. Epub 2018 Mar 16.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco (UCSF), San Francisco, California, USA.

The aim of this study was to evaluate the role of epithelial signal transducer and activator of transcription 3 (STAT3) in mouse incisor amelogenesis. Since Stat3 is expressed in the epithelial component of developing and adult mouse teeth, we generated and analyzed Krt14Cre/+;Stat3fl/fl mutant mice in which Stat3 was inactivated in epithelia including ameloblast progenitors and ameloblasts, the cells responsible for enamel formation. Histological analysis showed little enamel matrix in mutant incisors compared to controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000486745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023741PMC
March 2018
6 Reads

Functional Morphology of Thecal Glands in the Ovary of Japanese Quails (Coturnix japonica).

Cells Tissues Organs 2018 1;205(1):32-41. Epub 2018 Mar 1.

The role of thecal glands in the ovary of birds remains controversial. Using transmission electron microscopy and immunohistochemistry, immunohistochemical localisation of cyclooxygenase I and II (COX-1 and COX-2), oestrogen receptor α and β (ER-α and ER-β), androgen receptor (AR) and progesterone receptor (PR), a detailed analysis of the thecal glands was performed. Our ultrastructural studies revealed that the thecal glands of the quail ovary consist of 2 cell types, steroid-producing cells (SPCs) and enclosing cells (ENCs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000486544DOI Listing
March 2018
4 Reads

Osteoconduction of Unrestricted Somatic Stem Cells on an Electrospun Polylactic-Co-Glycolic Acid Scaffold Coated with Nanohydroxyapatite.

Cells Tissues Organs 2018 8;205(1):9-19. Epub 2018 Feb 8.

Department of Molecular Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

The limitation of traditional bone grafts could be overcome by applying engineered bone constructs, which are mainly produced by seeding suitable stem cells on appropriate scaffolds. So far, bone marrow-derived stromal cells have been the most applied cells in bone tissue engineering, but current data show that unrestricted somatic stem cells (USSCs) from human cord blood might actually be a better stem cell source due to the accessibility and noninvasive procedure of collection. In this study, we cultured USSCs on a plasma-treated electrospun polylactic-co-glycolic acid (PLGA) scaffold coated with nanohydroxyapatite (nHA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485122DOI Listing
February 2018
5 Reads

Ultramorphological Characteristics of Podocyte Development in the Human Fetal Metanephros.

Cells Tissues Organs 2018 7;205(1):42-52. Epub 2018 Feb 7.

Medical Faculty, University of Nis, Nis, Serbia.

The aim of this study was to determine the developmental characteristics of podocytes in the human fetal metanephros using scanning electron microscopy, light microscopy, and transmission electron microscopy. Kidney samples of 15 human fetuses of both sexes (gestational age 10-22 weeks) were analyzed. At the S-shaped body stage, primitive podocytes were arranged in a layer of cuboidal cells beneath the vascular cleft. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/486545
Publisher Site
http://dx.doi.org/10.1159/000486545DOI Listing
February 2018
8 Reads

Responsiveness of Infrapatellar Fat Pad Volume Change to Body Weight Loss or Gain: Data from the Osteoarthritis Initiative.

Cells Tissues Organs 2018 1;205(1):53-62. Epub 2018 Feb 1.

Obesity is a potent risk factor for knee osteoarthritis (OA) that is driven by mechanical and potentially endocrine mechanisms, and it affects women more frequently than men. The infrapatellar fat pat (IPFP) represents a potential link between obesity, intra-articular inflammation and structural pathology. Here we investigate whether the IPFP is responsive to body weight loss/gain in women and how its responsiveness to weight change compares to that of subcutaneous fat (SCF) of the thigh. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485833DOI Listing
February 2018
7 Reads

Human Embryonic Kidney 293 Cells: A Vehicle for Biopharmaceutical Manufacturing, Structural Biology, and Electrophysiology.

Cells Tissues Organs 2018 1;205(1):1-8. Epub 2018 Feb 1.

Mammalian cells, e.g., CHO, BHK, HEK293, HT-1080, and NS0 cells, represent important manufacturing platforms in bioengineering. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485501DOI Listing
February 2018
8 Reads

Porous Chitosan/Nano-Hydroxyapatite Composite Scaffolds Incorporating Simvastatin-Loaded PLGA Microspheres for Bone Repair.

Cells Tissues Organs 2018 1;205(1):20-31. Epub 2018 Feb 1.

The combination of bone tissue scaffolds with osteogenic induction factors is an effective strategy to facilitate bone healing processes. Here, chitosan (CS)/nano-hydroxyapatite (HA) scaffolds containing simvastatin (SIM)-loaded PLGA microspheres were fabricated by combining a freeze-drying technique with a modified water-oil-water emulsion method. The CS/HA weight ratio of 1:2 was selected by analyzing the effect of HA content on the micro-architecture, mechanical strength, and biocompatibility of the scaffold. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485502DOI Listing
February 2018
8 Reads

Erratum.

Authors:

Cells Tissues Organs 2017 14;204(5-6):313. Epub 2017 Dec 14.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000481717DOI Listing
December 2017
15 Reads

Expression Profile of NOTCH3 in Mouse Spermatogonia.

Cells Tissues Organs 2017 22;204(5-6):283-292. Epub 2017 Jan 22.

Laboratory of Molecular Embryology, Department of Genome System Science, Yokohama City University, Yokohama, Japan.

Stable and sustainable spermatogenesis is supported by the strict regulation of self-renewal and differentiation of spermatogonial stem cells (SSC), which are a rare population of undifferentiated spermatogonia. It has been revealed that some signaling factors regulate the self-renewal of SSC; however, the molecular mechanism of SSC maintenance is still not completely understood. Notch signaling is an evolutionarily conserved juxtacrine signaling that plays important roles in the cell fate determination of various tissue stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000481772DOI Listing
July 2018
8 Reads

Complete Static Repopulation of Decellularized Porcine Tissues for Heart Valve Engineering: An in vitro Study.

Cells Tissues Organs 2017 8;204(5-6):270-282. Epub 2017 Nov 8.

Department of Basic Medical Sciences, Ghent University, Ghent, Belgium.

To date, a completely in vitro repopulated tissue-engineered heart valve has not been developed. This study focused on sequentially seeding 2 cell populations onto porcine decellularized heart valve leaflets (HVL) and pericardia (PER) to obtain fully repopulated tissues. For repopulation of the interstitium, porcine valvular interstitial cells (VIC) and bone marrow-derived mesenchymal stem cells (BM-MSC) or adipose tissue-derived stem cells (ADSC) were used. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/480660
Publisher Site
http://dx.doi.org/10.1159/000480660DOI Listing
July 2018
20 Reads

Immunohistochemical Localization of Calbindin D28k, Parvalbumin, and Calretinin in the Superior Olivary Complex of Circling Mice.

Cells Tissues Organs 2017 4;204(5-6):304-313. Epub 2017 Nov 4.

Department of Pharmacology, Dankook University College of Medicine, Cheonan, South Korea.

The circling mouse serves as a hearing loss model. It has spontaneous tmie gene mutations that cause hair cell and cochlear degeneration. However, little is known about the role of the tmie gene in superior olivary complex (SOC) regions, in which sound information from the two ears is integrated and primarily relayed to the nuclei of the lateral lemniscus and inferior colliculus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000479961DOI Listing
July 2018
17 Reads