Complete Static Repopulation of Decellularized Porcine Tissues for Heart Valve Engineering: An in vitro Study.
Cells Tissues Organs 2017 Nov 8. Epub 2017 Nov 8.
Department of Basic Medical Sciences, Ghent University, Ghent, Belgium.
To date, a completely in vitro repopulated tissue-engineered heart valve has not been developed. This study focused on sequentially seeding 2 cell populations onto porcine decellularized heart valve leaflets (HVL) and pericardia (PER) to obtain fully repopulated tissues. For repopulation of the interstitium, porcine valvular interstitial cells (VIC) and bone marrow-derived mesenchymal stem cells (BM-MSC) or adipose tissue-derived stem cells (ADSC) were used. Read More