2,711 results match your criteria Cell research[Journal]


GABA receptor pas de deux: insights from high-resolution structures.

Authors:
Yi Jiang H Eric Xu

Cell Res 2020 Jul 10. Epub 2020 Jul 10.

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.

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http://dx.doi.org/10.1038/s41422-020-0373-yDOI Listing

Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1.

Cell Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41422-020-0365-yDOI Listing

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.

Cell Res 2020 Jul 7. Epub 2020 Jul 7.

Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.

The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). Read More

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http://dx.doi.org/10.1038/s41422-020-0364-zDOI Listing

Pulmonary alveolar regeneration in adult COVID-19 patients.

Cell Res 2020 Jul 6. Epub 2020 Jul 6.

National Institute of Biological Sciences, Beijing, 102206, China.

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http://dx.doi.org/10.1038/s41422-020-0369-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338112PMC

Omission of previous publications by an author should be corrected.

Authors:
Yi Rao

Cell Res 2020 Jul 6. Epub 2020 Jul 6.

PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.

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http://dx.doi.org/10.1038/s41422-020-0344-3DOI Listing

Author Correction: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.

Cell Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41422-020-0368-8DOI Listing

CryoEM structure of the tegumented capsid of Epstein-Barr virus.

Cell Res 2020 Jul 3. Epub 2020 Jul 3.

Cryo-Electron Microscopy Research Center, The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ portal from the tegumented capsid adopts a closed conformation with its channel valve holding the terminal viral DNA and with its crown region firmly engaged by three layers of ring-like dsDNA, which, together with the penton flexibility, effectively alleviates the capsid inner pressure placed on the portal cap. Read More

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http://dx.doi.org/10.1038/s41422-020-0363-0DOI Listing

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.

Cell Res 2020 Jul 1. Epub 2020 Jul 1.

MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Studies (CIIS), Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.

Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon (IFN) signaling pathway initiated by RIG-I-like receptors (RLRs), the sensors for RNA viruses. The expression of CCDC50 is enhanced by viral infection, and CCDC50 specifically recognizes K63-polyubiquitinated RLRs, thus delivering the activated RIG-I/MDA5 for autophagic degradation. Read More

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http://dx.doi.org/10.1038/s41422-020-0362-1DOI Listing
July 2020
12.413 Impact Factor

Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients.

Cell Res 2020 Jul 1. Epub 2020 Jul 1.

CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

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http://dx.doi.org/10.1038/s41422-020-0366-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327194PMC

Distinct stem/progenitor cells proliferate to regenerate the trachea, intrapulmonary airways and alveoli in COVID-19 patients.

Cell Res 2020 Jun 30. Epub 2020 Jun 30.

Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, 10032, NY, USA.

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http://dx.doi.org/10.1038/s41422-020-0367-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325636PMC

863 genomes reveal the origin and domestication of chicken.

Cell Res 2020 Jun 25. Epub 2020 Jun 25.

State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Despite the substantial role that chickens have played in human societies across the world, both the geographic and temporal origins of their domestication remain controversial. To address this issue, we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl (RJF). Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China, northern Thailand and Myanmar. Read More

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http://dx.doi.org/10.1038/s41422-020-0349-yDOI Listing

Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration.

Cell Res 2020 Jun 24. Epub 2020 Jun 24.

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully maintained is an open question. A replication-coupled DNA methylation maintenance model was proposed decades ago, but some observations suggest that a replication-uncoupled maintenance mechanism exists. Read More

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http://dx.doi.org/10.1038/s41422-020-0359-9DOI Listing

A special review collection on autophagy.

Authors:
Li Yu

Cell Res 2020 Jul;30(7):553

The State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Centre for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41422-020-0361-2DOI Listing

Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing.

Cell Res 2020 Jun 19. Epub 2020 Jun 19.

Department of Pharmacology & Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou, Zhejiang, 310009, China.

Common fragile sites (CFSs) are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes. They are hotspots for chromosome rearrangements and structural variations, which have been extensively implicated in carcinogenesis, aging, and other pathological processes. Although many CFSs were identified decades ago, a consensus is still lacking for why they are particularly unstable and sensitive to replication perturbations. Read More

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http://dx.doi.org/10.1038/s41422-020-0357-yDOI Listing

High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.

Cell Res 2020 Jun 19. Epub 2020 Jun 19.

Department of Molecular Biology, University of Geneva, 1205, Geneva, Switzerland.

DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we mapped, at high resolution, the genomic sites of MiDAS in cells treated with the DNA polymerase inhibitor aphidicolin. Read More

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http://dx.doi.org/10.1038/s41422-020-0358-xDOI Listing

Seeing is believing: a novel tool for quantitating mitophagy.

Cell Res 2020 Jun 19. Epub 2020 Jun 19.

Faculty of Health Sciences, University of Macau, Macau, China.

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http://dx.doi.org/10.1038/s41422-020-0360-3DOI Listing

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.

Cell Res 2020 Jun 19. Epub 2020 Jun 19.

VIB Center for Cancer Biology, Leuven, Belgium.

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs. Here, we profile 233,591 single cells from patients with lung, colorectal, ovary and breast cancer (n = 36) and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies. Read More

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http://dx.doi.org/10.1038/s41422-020-0355-0DOI Listing

Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis.

Cell Res 2020 Jun 16. Epub 2020 Jun 16.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders, including COVID-19. However, there are still no effective drugs to treat lung injury and fibrosis. In this study, we report the generation of clinical-grade human embryonic stem cells (hESCs)-derived immunity- and matrix-regulatory cells (IMRCs) produced under good manufacturing practice requirements, that can treat lung injury and fibrosis in vivo. Read More

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http://dx.doi.org/10.1038/s41422-020-0354-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296193PMC

Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly.

Cell Res 2020 Jun 15. Epub 2020 Jun 15.

Beijing Advanced Innovation Centre for Genomics, Peking-Tsinghua Centre for Life Sciences, Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, 100871, Beijing, China.

Single-cell RNA sequencing (scRNA-seq) has revolutionized transcriptomic studies by providing unprecedented cellular and molecular throughputs, but spatial information of individual cells is lost during tissue dissociation. While imaging-based technologies such as in situ sequencing show great promise, technical difficulties currently limit their wide usage. Here we hypothesize that cellular spatial organization is inherently encoded by cell identity and can be reconstructed, at least in part, by ligand-receptor interactions, and we present CSOmap, a computational tool to infer cellular interaction de novo from scRNA-seq. Read More

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http://dx.doi.org/10.1038/s41422-020-0353-2DOI Listing
June 2020
12.413 Impact Factor

Old dogs, new trick: classic cancer therapies activate cGAS.

Cell Res 2020 Jun 15. Epub 2020 Jun 15.

Department of Molecular Biology and Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

The discovery of cancer immune surveillance and immunotherapy has opened up a new era of cancer treatment. Immunotherapies modulate a patient's immune system to specifically eliminate cancer cells; thus, it is considered a very different approach from classic cancer therapies that usually induce DNA damage to cause cell death in a cell-intrinsic manner. However, recent studies have revealed that classic cancer therapies such as radiotherapy and chemotherapy also elicit antitumor immunity, which plays an essential role in their therapeutic efficacy. Read More

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http://dx.doi.org/10.1038/s41422-020-0346-1DOI Listing

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.

Cell Res 2020 Jun 15. Epub 2020 Jun 15.

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721, USA.

A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic. The disease caused by SARS-CoV-2 virus is called COVID-19, which is highly contagious and has an overall mortality rate of 6.35% as of May 26, 2020. Read More

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http://dx.doi.org/10.1038/s41422-020-0356-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294525PMC

Correction: Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.

Cell Res 2020 Jul;30(7):630

CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41422-020-0352-3DOI Listing
July 2020
12.413 Impact Factor

Secret(ory) revealed: the long-awaited structures of secretory IgA.

Authors:
Andrew B Herr

Cell Res 2020 Jul;30(7):558-559

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1038/s41422-020-0351-4DOI Listing

Social dominance hierarchy: toward a genetic and evolutionary understanding.

Authors:
Bruce T Lahn

Cell Res 2020 Jul;30(7):560-561

Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1038/s41422-020-0347-0DOI Listing

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions.

Cell Res 2020 Jun 4. Epub 2020 Jun 4.

Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, 92037, USA.

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microglia prominently contribute to the tumor mass. Read More

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http://dx.doi.org/10.1038/s41422-020-0338-1DOI Listing

Cryo-EM structures of inactive and active GABA receptor.

Cell Res 2020 Jul 3;30(7):564-573. Epub 2020 Jun 3.

Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China.

Metabotropic GABA G protein-coupled receptor functions as a mandatory heterodimer of GB1 and GB2 subunits and mediates inhibitory neurotransmission in the central nervous system. Each subunit is composed of the extracellular Venus flytrap (VFT) domain and transmembrane (TM) domain. Here we present cryo-EM structures of full-length human heterodimeric GABA receptor in the antagonist-bound inactive state and in the active state complexed with an agonist and a positive allosteric modulator in the presence of G protein at a resolution range of 2. Read More

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http://dx.doi.org/10.1038/s41422-020-0350-5DOI Listing

Fibroblasts fuel intestinal tumorigenesis.

Cell Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 601 Clinical Science Building, 96 Jonathan Lucas Street, Suite 601, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1038/s41422-020-0340-7DOI Listing

Combating pancreatic cancer during its Rip Van Winkle sleep.

Cell Res 2020 Jun 3. Epub 2020 Jun 3.

Comprehensive Cancer Center Munich at the Klinikum rechts der Isar (CCCMTUM), Technische Universität München, 81675, Munich, Germany.

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http://dx.doi.org/10.1038/s41422-020-0348-zDOI Listing

Ubiquitilated Fanconi ID complex embraces DNA.

Cell Res 2020 Jul;30(7):554-555

IFOM (Fondazione Istituto FIRC di Oncologia Molecolare) Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1038/s41422-020-0345-2DOI Listing

The future of cancer immunotherapy: microenvironment-targeting combinations.

Cell Res 2020 Jun 28;30(6):507-519. Epub 2020 May 28.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Immunotherapy holds the potential to induce durable responses, but only a minority of patients currently respond. The etiologies of primary and secondary resistance to immunotherapy are multifaceted, deriving not only from tumor intrinsic factors, but also from the complex interplay between cancer and its microenvironment. In addressing frontiers in clinical immunotherapy, we describe two categories of approaches to the design of novel drugs and combination therapies: the first involves direct modification of the tumor, while the second indirectly enhances immunogenicity through alteration of the microenvironment. Read More

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http://dx.doi.org/10.1038/s41422-020-0337-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264181PMC

Immune checkpoint signaling and cancer immunotherapy.

Authors:
Xing He Chenqi Xu

Cell Res 2020 May 28. Epub 2020 May 28.

State Key Laboratory of Molecular Biology, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

Immune checkpoint blockade therapy has become a major weapon in fighting cancer. Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such as broad applicability across cancer types and durable clinical response when treatment is effective. However, the overall response rates are still unsatisfying, especially for cancers with low mutational burden. Read More

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http://dx.doi.org/10.1038/s41422-020-0343-4DOI Listing

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.

Cell Res 2020 May 26. Epub 2020 May 26.

State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - including mTOR, associated with extramammary PD. Read More

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http://dx.doi.org/10.1038/s41422-020-0334-5DOI Listing

USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.

Cell Res 2020 May 26. Epub 2020 May 26.

Department of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.

Cyclic GMP-AMP synthase (cGAS) is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity. Modulating the activity and stability of cGAS provides potential strategies for treating viral or autoimmune diseases. Here, we report that ubiquitin-specific protease 29 (USP29) deubiquitinates and stabilizes cGAS and promotes cellular antiviral responses and autoimmunity. Read More

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http://dx.doi.org/10.1038/s41422-020-0341-6DOI Listing

Making ends meet in class switch recombination.

Cell Res 2020 May 25. Epub 2020 May 25.

Department of immunobiology, Yale School of Medicine, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1038/s41422-020-0342-5DOI Listing

Author Correction: N-methyladenine is incorporated into mammalian genome by DNA polymerase.

Cell Res 2020 May 25. Epub 2020 May 25.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 100085, Beijing, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41422-020-0339-0DOI Listing
May 2020
12.413 Impact Factor

Interaction between microbiota and immunity in health and disease.

Cell Res 2020 Jun 20;30(6):492-506. Epub 2020 May 20.

Immunology Department, Weizmann Institute of Science, 234 Herzl Street, 7610001, Rehovot, Israel.

The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host's innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Read More

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http://dx.doi.org/10.1038/s41422-020-0332-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264227PMC

Reprogramming the microenvironment: tricks of tumor-derived astrocytes.

Cell Res 2020 May 18. Epub 2020 May 18.

Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41422-020-0335-4DOI Listing

Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma.

Cell Res 2020 May 12. Epub 2020 May 12.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Esophageal squamous cell carcinoma (ESCC) is a poor-prognosis cancer type with limited understanding of its molecular etiology. Using 508 ESCC genomes, we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients' outcomes. Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function, or even conferred oncogenic activities. Read More

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http://dx.doi.org/10.1038/s41422-020-0333-6DOI Listing
May 2020
12.413 Impact Factor

Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.

Cell Res 2020 Jul 12;30(7):602-609. Epub 2020 May 12.

State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing, 100871, China.

Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. Read More

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http://dx.doi.org/10.1038/s41422-020-0336-3DOI Listing

Forks in the road to the first hematopoietic stem cells.

Cell Res 2020 Jun;30(6):457-458

Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41422-020-0331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264252PMC

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity.

Cell Res 2020 Jun 6;30(6):475-491. Epub 2020 May 6.

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, 10021, USA.

The multifaceted organization of the immune system involves not only patrolling lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs but also immune cells that establish permanent tissue-residency. The integration in the respective tissue and the adaption to the organ milieu enable tissue-resident cells to establish signaling circuits with parenchymal cells to coordinate immune responses and maintain tissue homeostasis. Innate lymphoid cells (ILCs) are tissue-resident innate immune cells that have a similar functional diversity to T cells including lineage-specifying transcription factors that drive certain effector programs. Read More

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http://dx.doi.org/10.1038/s41422-020-0323-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264134PMC

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis.

Cell Res 2020 Jun 6;30(6):520-531. Epub 2020 May 6.

Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7. Read More

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http://dx.doi.org/10.1038/s41422-020-0319-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264146PMC

Enabling anti-tumor immunity by unleashing ILC2.

Cell Res 2020 Jun;30(6):461-462

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.

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http://dx.doi.org/10.1038/s41422-020-0330-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264216PMC

A β-galactosidase kiss of death for senescent cells.

Cell Res 2020 Jul;30(7):556-557

Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, 100053, Beijing, China.

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http://dx.doi.org/10.1038/s41422-020-0325-6DOI Listing

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex.

Cell Res 2020 Jun 4;30(6):532-540. Epub 2020 May 4.

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang, 310024, China.

The nuclear pore complex (NPC) mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells. Here we report the cryo-electron tomography (cryo-ET) structure of the luminal ring (LR) of the NPC from Xenopus laevis oocyte. The observed key structural features of the LR are independently confirmed by single-particle cryo-electron microscopy (cryo-EM) analysis. Read More

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http://dx.doi.org/10.1038/s41422-020-0320-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264284PMC

Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases.

Cell Res 2020 Jun 4;30(6):465-474. Epub 2020 May 4.

Experimental immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Naturally arising regulatory CD4 T (Treg) cells, which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell subpopulation specialized for immune suppression, playing a key role in maintaining immunological self-tolerance and homeostasis. FoxP3 is required for Treg function, especially for its suppressive activity. However, FoxP3 expression per se is not necessary for Treg cell lineage commitment in the thymus and insufficient for full Treg-type gene expression in mature Treg cells. Read More

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http://dx.doi.org/10.1038/s41422-020-0324-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264322PMC

ILC transdifferentiation: roles in cancer progression.

Cell Res 2020 Jul;30(7):562-563

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41422-020-0326-5DOI Listing

Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.

Cell Res 2020 Jul 4;30(7):610-622. Epub 2020 May 4.

CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

Innate lymphoid cells (ILCs) reside in mucosal surfaces to potentiate immune responses, sustain mucosal integrity and maintain tissue homeostasis. However, how tumor infiltrating ILCs modulate tumor development and progression is unclear. Here we profiled tumor infiltrating ILCs during colorectal cancer (CRC) progression by single-cell RNA sequencing. Read More

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http://dx.doi.org/10.1038/s41422-020-0312-yDOI Listing
July 2020
12.413 Impact Factor

The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals.

Cell Res 2020 Apr 30. Epub 2020 Apr 30.

National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Metabolic diseases are the most common and rapidly growing health issues worldwide. The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders. The China Metabolic Analytics Project (ChinaMAP) is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China. Read More

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http://dx.doi.org/10.1038/s41422-020-0322-9DOI Listing
April 2020
12.413 Impact Factor

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.

Cell Res 2020 Apr 30. Epub 2020 Apr 30.

State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.

Programmed DNA recombination in mammalian cells occurs predominantly in a directional manner. While random DNA breaks are typically repaired both by deletion and by inversion at approximately equal proportions, V(D)J and class switch recombination (CSR) of immunoglobulin heavy chain gene overwhelmingly delete intervening sequences to yield productive rearrangement. What factors channel chromatin breaks to deletional CSR in lymphocytes is unknown. Read More

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http://dx.doi.org/10.1038/s41422-020-0328-3DOI Listing