9 results match your criteria Cell health and cytoskeleton[Journal]

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Alterations in cancer cell mechanical properties after fluid shear stress exposure: a micropipette aspiration study.

Cell Health Cytoskelet 2015 Jan;7:25-35

Department of Biomedical Engineering, Holden Comprehensive Cancer Center, University of Iowa, Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, USA.

Over 90% of cancer deaths result not from primary tumor development, but from metastatic tumors that arise after cancer cells circulate to distal sites via the circulatory system. While it is known that metastasis is an inefficient process, the effect of hemodynamic parameters such as fluid shear stress (FSS) on the viability and efficacy of metastasis is not well understood. Recent work has shown that select cancer cells may be able to survive and possibly even adapt to FSS in vitro. Read More

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http://dx.doi.org/10.2147/CHC.S71852DOI Listing
January 2015
15 Reads


Cell Health Cytoskelet 2015 18;7:1-10. Epub 2014 Dec 18.

Department of Biochemistry, Ponce School of Medicine, Ponce, PR, USA.

was the first tumor suppressor gene discovered. Over four decades of work have revealed that the Rb protein (pRb) is a master regulator of biological pathways influencing virtually every aspect of intrinsic cell fate including cell growth, cell-cycle checkpoints, differentiation, senescence, self-renewal, replication, genomic stability and apoptosis. While these many processes may account for a significant portion of 's potency as a tumor suppressor, a small, but growing stream of evidence suggests that also significantly influences how a cell interacts with its environment, including cell-to-cell and cell-to-extracellular matrix interactions. Read More

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http://dx.doi.org/10.2147/CHC.S28079DOI Listing
December 2014
1 Read

Classification of axonal subtypes based on cytoskeletal components.

Cell Health Cytoskelet 2014 11;6:1-10. Epub 2014 Apr 11.

Department of Biomedical Engineering, College of Engineering, University of Miami, Miami, FL, USA.

Background: Retinal ganglion cells are often classified into different subtypes according to their morphology or physiological functions. The axons of RGCs contain three major cytoskeletal components: actin filaments (F-actin); microtubules; and neurofilaments (NFs). The contents of these components vary among axons. Read More

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http://dx.doi.org/10.2147/CHC.S57081DOI Listing
April 2014
2 Reads

New developments in C5a receptor signaling.

Cell Health Cytoskelet 2012 Jul 31;4:73-82. Epub 2012 Jul 31.

University of Michigan Medical School, Department of Pathology, Ann Arbor, MI, USA.

Complement activation usually results in the formation of complement fragment 5a (C5a) that interacts with its two receptors, C5aR and C5L2. These receptors belong to the rhodopsin family of G protein-coupled seven transmembrane-containing receptors. C5aR and C5L2 are expressed on/in a wide variety of cells and tissues. Read More

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http://dx.doi.org/10.2147/CHC.S27233DOI Listing
July 2012
9 Reads

The effect of nicotine on the mechanical properties of mesenchymal stem cells.

Cell Health Cytoskelet 2012 Mar;4:29-35

Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA ; Research Service and Geriatrics Research, Education, and Clinical Center, Veterans Affairs Medical Center, Miami, FL, USA.

PURPOSE: To measure the elasticity of the nucleus and cytoplasm of human mesenchymal stem cells (MSCs) as well as changes brought about by exposure to nicotine in vitro. METHODS: MSCs were synchronized to the G(0) stage of the cell cycle through serum deprivation techniques. The cells were then treated with medium containing nicotine (0. Read More

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http://dx.doi.org/10.2147/CHC.S24381DOI Listing
March 2012
5 Reads

Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress.

Cell Health Cytoskelet 2012 Feb;2012(4):11-27

Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE.

Flavoproteins catalyze a variety of reactions utilizing flavin mononucleotide or flavin adenine dinucleotide as cofactors. The oxidoreductase properties of flavoenzymes implicate them in redox homeostasis, oxidative stress, and various cellular processes, including programmed cell death. Here we explore three critical flavoproteins involved in apoptosis and redox signaling, ie, apoptosis-inducing factor (AIF), proline dehydrogenase, and NADPH oxidase. Read More

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http://dx.doi.org/10.2147/CHC.S4955DOI Listing
February 2012
1 Read

N-glycosylation status of E-cadherin controls cytoskeletal dynamics through the organization of distinct β-catenin- and γ-catenin-containing AJs.

Cell Health Cytoskelet 2009 Sep;2009(1):67-80

Department of Molecular and Cell Biology, Boston University Medical Center, Boston, MA, USA.

N-glycosylation of E-cadherin has been shown to inhibit cell-cell adhesion. Specifically, our recent studies have provided evidence that the reduction of E-cadherin N-glycosylation promoted the recruitment of stabilizing components, vinculin and serine/threonine protein phosphatase 2A (PP2A), to adherens junctions (AJs) and enhanced the association of AJs with the actin cytoskeleton. Here, we examined the details of how N-glycosylation of E-cadherin affected the molecular organization of AJs and their cytoskeletal interactions. Read More

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http://dx.doi.org/10.2147/chc.s5965DOI Listing
September 2009
8 Reads

Endothelial contractile cytoskeleton and microvascular permeability.

Cell Health Cytoskelet 2009 Jul;2009(1):43-50

Division of Research, Department, of Surgery, University of California, at Davis School of Medicine, Sacramento, CA, USA.

Microvascular barrier dysfunction represents a significant problem in clinical conditions associated with trauma, burn, sepsis, acute respiratory distress syndrome, ischemia-reperfusion injury, and diabetic retinopathy. An important cellular mechanism underlying microvascular leakage is the generation of contractile force from the endothelial cytoskeleton, which counteracts cell-cell and cell-matrix adhesions leading to paracellular hyperpermeability. In this review, we present recent experimental evidence supporting the critical role of MLCK-activated, RhoA/ROCK-regulated contractile cytoskeleton in endothelial permeability response to inflammatory and thrombotic stimuli arising from thermal injury, activated neutrophils, vascular endothelial growth factor, and fibrinogen degradation products. Read More

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http://dx.doi.org/10.2147/chc.s5118DOI Listing
July 2009
59 Reads

HSP20 phosphorylation and airway smooth muscle relaxation.

Cell Health Cytoskelet 2009 Jun;2009(1):27-42

Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, USA.

HSP20 (HSPB6) is a small heat shock protein expressed in smooth muscles that is hypothesized to inhibit contraction when phosphorylated by cAMP-dependent protein kinase. To investigate this hypothesis in airway smooth muscle (ASM) we showed that HSP20 was constitutively expressed as well as being inducible in cultured hASM cells by treatment with 1 μM isoproterenol or 10 μM salmeterol. In contrast, a mixture of proinflammatory mediators (interleukin-1β, tumor necrosis factor α, and interferon γ) inhibited expression of HSP20 by about 50% in 48 hours. Read More

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http://dx.doi.org/10.2147/chc.s5783DOI Listing
June 2009
3 Reads
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