1,314,992 results match your criteria Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research[Journal]


Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1 resulting in tumor proliferation in CRC.

Cancer Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

BRAF mutation accounts for up to 90 % of all BRAF mutations in human colorectal cancer (CRC), and constitutively activates the MEK-MAPK pathway. It is recognized that neutralizing monoclonal antibodies for epidermal growth factor receptor alone are not effective for CRC with BRAF mutation. Therefore, there are increasing interests in identification of the possible therapeutic targets in downstream of BRAF mutation in CRCs. Read More

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http://dx.doi.org/10.1111/cas.14558DOI Listing

Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition.

Aging (Albany NY) 2020 Jul 6;12. Epub 2020 Jul 6.

Department of Cardiovascular Surgery, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, P.R. China.

Long non-coding RNAs (lncRNAs) have been largely reported to contribute to the development and progression of abdominal aortic aneurysm (AAA), a common vascular degenerative disease. The present study was set out with the aim to investigate the possible role of lncRNA Sox2ot in the development of AAA. In this study, we found that lncRNA Sox2ot and early growth response factor-1 (Egr1) were highly expressed, while microRNA (miR)-145 was poorly expressed in Ang II-induced AAA mice and oxidative stress-provoked vascular smooth muscle cell (VSMC) model. Read More

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http://dx.doi.org/10.18632/aging.103077DOI Listing

Extended Metabolic Biosensor Design for Dynamic Pathway Regulation of Cell Factories.

iScience 2020 Jun 23;23(7):101305. Epub 2020 Jun 23.

Synthetic Biology and Biosystems Control Lab, I.U. de Automática e Informática Industrial (ai2), Universitat Politècnica de València, Camí de Vera S/N, 46022 Valencia, Spain. Electronic address:

Transcription factor-based biosensors naturally occur in metabolic pathways to maintain cell growth and to provide a robust response to environmental fluctuations. Extended metabolic biosensors, i.e. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101305DOI Listing

Damage-associated molecular patterns in tumor radiotherapy.

Int Immunopharmacol 2020 Jul 3;86:106761. Epub 2020 Jul 3.

Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Radiotherapy is one of the most common modalities for the treatment of cancer. One of the most promising effects of radiotherapy is immunologic cell death and the release of danger alarms, which are known as damage-associated molecular patterns (DAMPs). DAMPs are able to trigger cancer cells and other cells within tumor microenvironment (TME), either for suppression or promotion of tumor growth. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106761DOI Listing

A novel CO steady feeding based on the pH steady strategy data in the Haematococcus pluvialis cultivation to maximize the cell growth and carbon bio-sequestration.

Bioresour Technol 2020 Jun 28;314:123752. Epub 2020 Jun 28.

Microbial Biotechnology Department, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran. Electronic address:

Two common strategies to feed the CO are pH steady (PS) and CO steady (CS). An innovative strategy called ''CSBPS (CS feeding based on PS data)" in comparison to the 0.04% CS, 5% CS, and PS approaches improved the Haematococcus pluvialis growth and carbon bio-sequestration. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123752DOI Listing

Foliar application of silicon improves stem strength under low light stress by regulating lignin biosynthesis genes in soybean (Glycine max (L.) Merr.).

J Hazard Mater 2020 Jun 21;401:123256. Epub 2020 Jun 21.

College of Agronomy, Sichuan Agricultural University, 211-Huimin Road, Wenjiang District, Chengdu 611130, PR China; Sichuan Engineering Research Center for Crop Strip Intercropping System, Key Laboratory of Crop Ecophysiology and Farming System in Southwest China (Ministry of Agriculture), Sichuan Agricultural University, Chengdu, PR China. Electronic address:

In order to improve soybean's resistance to lodging, silicon (Si) solutions at concentrations of 0,100, 200,300 mg kg were applied during the seedling stage. The Si accumulation in different parts of the plants, the photosynthetic parameters of leaves and chlorophyll content, the stem bending resistance, the expression of genes of lignin biosynthesis and associated enzyme activity and sap flow rates were measured at early and late growth stages. The potential mechanisms for how Si improve growth and shade tolerance, enhances lodging resistance and improves photosynthesis were analyzed to provide a theoretical basis for the use of Si amendments in agriculture. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123256DOI Listing

Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway.

Bioorg Chem 2020 Jun 25;101:104036. Epub 2020 Jun 25.

Department of Pharmacology, Dalian Medical University, Dalian 116044, China. Electronic address:

Oleanolic acid (OA) and its semi-synthetic derivatives have been reported to have a wide range of biological activities. The introduction of electrophilic Michael acceptor group can increase the reactivity of OA to cellular targets and thus improve the anti-tumor activity. In this work, a series of novel α,β-unsaturated carbonyl derivatives of OA were designed and synthesized. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104036DOI Listing

Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.

Neoplasia 2020 Jul 3;22(9):365-375. Epub 2020 Jul 3.

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China. Electronic address:

The addition of bevacizumab to chemotherapy has prolonged overall and progression-free survival rates for metastatic colorectal cancer (mCRC). However, KRAS-mutant (KRAS-mut) CRC, lacking an ideal targeted agent, represents an inferior-response subgroup of patients. In the present study, we investigated a combination approach of bevacizumab + olaparib in KRAS-mut CRC in a preclinical setting. Read More

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http://dx.doi.org/10.1016/j.neo.2020.06.001DOI Listing

Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer.

Int J Radiat Oncol Biol Phys 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiation Oncology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

The complement system consists of a collection of serum proteins, which act as the main frontline effector arm of the innate immune system. Activation of complement can occur through the individual induction pathways: the classical, mannose-binding lectin, and alternative pathways. Activation results in opsonization, recruitment of effector cells through potent immune mediators known as anaphylatoxins, and cell lysis via the formation of the membrane attack complex (MAC). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.067DOI Listing

Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis.

Neurosci Lett 2020 Jul 3:135153. Epub 2020 Jul 3.

Department of Integrated TCM & Western Medicine, Liaoning Cancer Hospital &Institute, Shenyang, Liaoning, 110043, China.

Background: Circular RNAs (circRNAs) are related to the carcinogenesis of cancers, including glioma. However, the role and mechanism of circRNA pleiotrophin (circ-PTN) remain largely unknown.

Methods: Glioma tissues (n = 30) and normal tissues were obtained. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135153DOI Listing

Circular RNA circ-ZEB1 acts as an oncogene in triple negative breast cancer via sponging miR-448.

Int J Biochem Cell Biol 2020 Jul 3:105798. Epub 2020 Jul 3.

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address:

Background: Circular RNAs (circRNAs) play an important role in tumor development. The miRNA sponge is a common role played by circRNAs in various tumors, including breast cancer.

Objective: This study aimed to explore the role of circ-ZEB1 in the proliferation and apoptosis of triple negative breast cancer (TNBC) cells. Read More

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http://dx.doi.org/10.1016/j.biocel.2020.105798DOI Listing

circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction.

Life Sci 2020 Jul 3:118015. Epub 2020 Jul 3.

Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, PR China. Electronic address:

Background: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118015DOI Listing

Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish.

Dev Biol 2020 Jul 3. Epub 2020 Jul 3.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. Electronic address:

ETS transcription factors play an important role in the specification and differentiation of endothelial cells during vascular development. Despite previous studies, the role of the founding member of the ETS family, Ets1, in vascular development in vivo is only partially understood. Here, we generated a zebrafish ets1 mutant by TALEN genome editing and tested functional redundancy between Ets1 and a related ETS factor Etv2/Etsrp/ER71. Read More

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http://dx.doi.org/10.1016/j.ydbio.2020.06.007DOI Listing

Levodopa Positively Affects Neovascular Age-related Macular Degeneration.

Am J Med 2020 Jul 3. Epub 2020 Jul 3.

Snyder Biomedical Corporation, Tucson, AZ 85712, USA; Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, 85721, USA.

Background: Age-related macular degeneration (AMD) is a common cause of blindness worldwide. Neovascular AMD (nAMD) is an advanced form of the disease, in which excess vascular endothelial growth factor (VEGF) induces growth of new blood vessels that leak fluid, accounting for 90% of vision loss in AMD. Dysfunction of the retinal pigment epithelium likely initiates AMD. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.05.038DOI Listing

TGFBR2 regulates Hedgehog pathway and cervical cancer cell proliferation and migration by mediating SMAD4.

J Proteome Res 2020 Jul 6. Epub 2020 Jul 6.

TGFBR2 serves as an initial regulator of the TGF-β signaling pathway, and loss or reduction of its expression can lead to uncontrolled cell growth. This study was conducted to further explore the mechanism of TGFBR2/SMAD4 on the migration and proliferation of CC cells. Here, TGFBR2 and SMAD4 expressions in CC cells and control cells were measured. Read More

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http://dx.doi.org/10.1021/acs.jproteome.0c00239DOI Listing

Synthesis of Chiral Bis(3-indolyl)methanes Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter via Nickel-catalyzed Asymmetric Friedel-Crafts Alkylation Reaction.

J Org Chem 2020 Jul 6. Epub 2020 Jul 6.

Bis(3-indolyl)methanes are well known natural products with a broad range of important biological functions including cancer cell growth inhibition and anti-microbial activity. Incorporation of a trifluoromethyl group is known to have a profound effect on the parent compound's biological activities. Here an efficient method for the synthesis of chiral trifluoromethylated bis(3-indolyl)methanes via a catalytic asymmetric Friedel-Crafts (F-C) alkylation reaction has been established. Read More

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http://dx.doi.org/10.1021/acs.joc.0c00336DOI Listing

Doxycycline induces Hok toxin killing in host E. coli.

PLoS One 2020 6;15(7):e0235633. Epub 2020 Jul 6.

Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, London, England, United Kingdom.

The antibacterial efficacy of the tetracycline antibiotics has been greatly reduced by the development of resistance, hence a decline in their clinical use. The hok/sok locus is a type I toxin/antitoxin plasmid stability element, often associated with multi-drug resistance plasmids, especially ESBL-encoding plasmids. It enhances host cell survivability and pathogenicity in stressful growth conditions, and increases bacterial tolerance to β-lactam antibiotics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235633PLOS

GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae.

PLoS Negl Trop Dis 2020 Jul 6;14(7):e0007871. Epub 2020 Jul 6.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Leprosy, caused by Mycobacterium leprae, has plagued humanity for thousands of years and continues to cause morbidity, disability and stigmatization in two to three million people today. Although effective treatment is available, the disease incidence has remained approximately constant for decades so new approaches, such as vaccine or new drugs, are urgently needed for control. Research is however hampered by the pathogen's obligate intracellular lifestyle and the fact that it has never been grown in vitro. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007871DOI Listing

Formicins, -Acetylcysteamine-Bearing Indenone Thioesters from a Wood Ant-Associated Bacterium.

Org Lett 2020 Jul 6. Epub 2020 Jul 6.

Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Formicins A-C (-) were discovered from sp. associated with wood ants. The structures of and were elucidated as indenone thioesters bearing -acetylcysteamine based on spectroscopic analysis. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01584DOI Listing

Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic .

J Nat Prod 2020 Jul 6. Epub 2020 Jul 6.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

Five new drimane-type sesquiterpenoids, named proversilins A-E (-), were isolated from the endophytic fungus F210 isolated from the bulbs of . Their structures and absolute configurations were characterized by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data, comparison of experimental and calculated electronic circular dichroism data, and X-ray crystallography. Proversilins B-E (-) represent the first examples of natural products featuring an -acetyl-β-phenylalanine moiety. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.0c00298DOI Listing

Ultrasound-Augmented Phase Transition Nanobubbles for Targeted Treatment of Paclitaxel-Resistant Cancer.

Bioconjug Chem 2020 Jul 6. Epub 2020 Jul 6.

The paclitaxel (PTX) resistance in most epithelial ovarian cancers (EOCs) with increasing membrane expression of mucin 16 (MUC16) is mediated by the Toll-like receptor-myeloid differentiation factor 2/myeloid differentiation factor 88 (TLR4-MD2/MyD88) signaling pathway. 6-shogaol (6S), an α, β-unsaturated carbonyl compound with lipophilic property, can block PTX-induced formation of the TLR4/MD-2 complex that activates the MyD88/NF-кВ signaling pathway. Herein, to improve the effectiveness of 6S, augment the sensibility of PTX, and enhance the targeting ability of PTX-resistant cancer therapies, we report a class of 6S-loaded phase transition nanobubbles conjugated with the MUC16 antibody (6S@NBs-MUC16A), which can enhance the sensibility of PTX to EOC cells through ultrasound-controlled targeted-delivery of 6S. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00364DOI Listing

Delta-9-tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells.

Physiol Rep 2020 Jul;8(13):e14476

Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

The psychoactive component in cannabis, delta-9-tetrahydrocannabinol, can restrict fetal growth and development. Delta-9-tetrahydrocannabinol has been shown to negatively impact cellular proliferation and target organelles like the mitochondria resulting in reduced cellular respiration. In the placenta, mitochondrial dysfunction leading to oxidative stress prevents proper placental development and function. Read More

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http://dx.doi.org/10.14814/phy2.14476DOI Listing

Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells.

Phytother Res 2020 Jul 6. Epub 2020 Jul 6.

Epithelial Biology Laboratory, Department of Periodontics and Oral Medicine, Division of Oral Pathology Oral Radiology and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Curcumin, a polyphenol isolated from the rhizome of Curcuma longa, has been studied because of its antioxidant, antimicrobial, and antiinflammatory properties. This study aimed to evaluate the effects of curcumin on head and neck cancer (HNC) cell lines and how it modulates the PI3K-AKT-mTOR signaling pathway. Dose-response curves for curcumin were established for hypopharynx carcinoma (FaDu), tongue carcinoma (SCC-9), and keratinocytes (HaCaT) cell lines and IC values were calculated. Read More

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http://dx.doi.org/10.1002/ptr.6780DOI Listing

The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination.

Diagn Cytopathol 2020 Jul 6. Epub 2020 Jul 6.

Department of Clinical Engineering and Medical Technology, Niigata University Health and Welfare, Niigata, Japan.

Background: Nonspecific vaginitis, also known as Bacterial vaginosis, unlike genital candidiasis and trichomoniasis, is caused by microbiome breakdown. Döderlein's bacillus are gram-positive bacillus that form a microbiome, reproduce in the female vagina after gaining sexual maturity, secrete lactic acid, and prevent the growth of other vaginitis-causing bacteria. Clue cell are squamous epithelial cells with Gardnerella sp. Read More

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http://dx.doi.org/10.1002/dc.24538DOI Listing

Bronchiolitis and recurrent wheezing are distinguished by type 2 innate lymphoid cells and immune response.

Pediatr Allergy Immunol 2020 Jul 6. Epub 2020 Jul 6.

Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain.

Background: Recurrent wheezing (RW) is frequently developed in infants that have suffered bronchiolitis (BCH) during first months of life but the immune mechanism underlying is not clear. The goal was to analyse the innate immune response that characterizes BCH and RW.

Methods: Ninety-eight and seventy hospitalized infants with BCH or RW diagnosis respectively were included. Read More

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http://dx.doi.org/10.1111/pai.13317DOI Listing

Cancer-driven IgG promotes the development of prostate cancer though the SOX2-CIgG pathway.

Prostate 2020 Jul 6. Epub 2020 Jul 6.

Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.

Background: Although androgen deprivation therapy (ADT) is the initial treatment strategy for prostate cancer (PCa), recurrent castration-resistant prostate cancer (CRPC) eventually ensues. In this study, cancer-derived immunoglobulin G (CIgG) is found to be induced after ADT, identifying CIgG as a potential CRPC driver gene.

Methods: The expression of CIgG and its clinical significance in PCa tissue was analyzed by The Cancer Genome Atlas database and immunohistochemistry. Read More

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http://dx.doi.org/10.1002/pros.24042DOI Listing

Fabrication of Surface Acoustic Wave Devices on Lithium Niobate.

J Vis Exp 2020 Jun 18(160). Epub 2020 Jun 18.

Medically Advanced Devices Laboratory, Center for Medical Devices and Instrumentation, Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering and Department of Surgery, School of Medicine, University of California San Diego;

Manipulation of fluids and particles by acoustic actuation at small scale is aiding the rapid growth of lab-on-a-chip applications. Megahertz-order surface acoustic wave (SAW) devices generate enormous accelerations on their surface, up to 10 m/s, in turn responsible for many of the observed effects that have come to define acoustofluidics: acoustic streaming and acoustic radiation forces. These effects have been used for particle, cell, and fluid handling at the microscale-and even at the nanoscale. Read More

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http://dx.doi.org/10.3791/61013DOI Listing

LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.

Aging (Albany NY) 2020 Jul 4;12. Epub 2020 Jul 4.

Department of Immunology, School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, Shandong, P.R. China.

Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Read More

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http://dx.doi.org/10.18632/aging.103589DOI Listing

Exosome-transmitted microRNA-133b inhibited bladder cancer proliferation by upregulating dual-specificity protein phosphatase 1.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Laboratory Medicine Center, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Bladder Cancer (BC) is the ninth most common tumor in the world and one of the most common malignant tumors of the urinary system. Some studies reported that miR-133b expression is reduced in BC, but whether it plays a role in the development of BC and its mechanism is unclear. microRNAs can be packaged into exosomes to mediate communication between tumor cells, affecting their proliferation and apoptosis. Read More

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http://dx.doi.org/10.1002/cam4.3263DOI Listing

Altered properties of endothelial cells and mesenchymal stem cells underlying the development of scleroderma-like vasculopathy in Klf5 ;Fli1 mice.

Arthritis Rheumatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Objective: We previously established a new animal model (Klf5 ;Fli1 mice) broadly recapitulating fundamental pathologic features of systemic sclerosis (SSc). SSc vasculopathy is believed to occur as a result of impaired vascular remodeling, but its detailed mechanism has remained unknown. To address this issue, we investigated the properties of dermal microvascular endothelial cells (DMECs), bone marrow-derived endothelial progenitor cells (BM-EPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs), a precursor of pericytes, in Klf5 ;Fli1 mice. Read More

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http://dx.doi.org/10.1002/art.41423DOI Listing

Circ-SPECC1 modulates TGFβ2 and autophagy under oxidative stress by sponging miR-33a to promote hepatocellular carcinoma tumorigenesis.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Circular RNAs (circRNAs) play vital roles in the pathogenesis and development of multiple cancers, including hepatocellular carcinoma (HCC). Nevertheless, the regulatory mechanisms of circ-SPECC1 in HCC remain poorly understood. In our study, we found that circ-SPECC1 was apparently downregulated in H O -treated HCC cells. Read More

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http://dx.doi.org/10.1002/cam4.3219DOI Listing

Prohibitin 1 (PHB1) controls growth and development and regulates proliferation and apoptosis in Schistosoma japonicum.

FASEB J 2020 Jul 6. Epub 2020 Jul 6.

School of Basic Medical Sciences, Wuhan University, Wuhan, P.R. China.

Schistosomiasis is a zoonotic parasitic disease caused by the trematode blood flukes of the genus Schistosoma. The prodigious egg output of females is the main cause of the disease in definitive hosts, while the female worm relies on continuous pairing with the male worm to fuel the growth and maturation of the reproductive organs and egg production. Prohibitin, which contains the functionally interdependent PHB1 and PHB2 subunits in human and some other species, has been proposed to participate in the cell proliferation and apoptosis regulation in mammals. Read More

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http://dx.doi.org/10.1096/fj.201902787RRRDOI Listing

Optical Pliers: Micrometer-Scale, Light-Driven Tools Grown on Optical Fibers.

Adv Mater 2020 Jul 6:e2002779. Epub 2020 Jul 6.

Photonic Nanostructure Facility, Faculty of Physics, University of Warsaw, ul. Pasteura 5, Warsaw, 02-093, Poland.

The ability to grip and handle small objects, from sub-millimeter electronic components to single-micrometer living cells, is vital for numerous ever-shrinking technologies. Mechanical grippers, powered by electric, pneumatic, hydraulic or piezoelectric servos, are well suited for the job at larger scales, but their complexity and need for force transmission prevent their miniaturization and remote control in tight spaces. Using liquid crystal elastomer microstructures that can change shape quickly and reversibly in response to light, a light-powered gripping tool-optical pliers-is built by growing two bending jaws on the tips of optical fibers. Read More

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http://dx.doi.org/10.1002/adma.202002779DOI Listing

Organic-Salt-Assisted Crystal Growth and Orientation of Quasi-2D Ruddlesden-Popper Perovskites for Solar Cells with Efficiency over 19.

Adv Mater 2020 Jul 6:e2001470. Epub 2020 Jul 6.

The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Quasi-2D Ruddlesden-Popper (RP) perovskite solar cells (PSCs) have drawn significant attention due to their appealing environmental stability compared to their 3D counterparts. However, the relatively low power conversion efficiency (PCE) greatly limits their applications. Here, high photovoltaic performance is demonstrated for quasi-2D RP PSCs using 2-thiophenemethylammonium as spacer with nominal n-value of 5, which is based on the stoichiometry of the precursors. Read More

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http://dx.doi.org/10.1002/adma.202001470DOI Listing

Concentrated Growth Factor inhibit UVA-induced photoaging in Human Dermal Fibroblasts via the MAPK/AP-1 pathway.

Biosci Rep 2020 Jul 6. Epub 2020 Jul 6.

Hebei Medical University, Shijiazhuang, China.

Ultraviolet (UV) radiation-induced photoaging is one of the contributors to skin aging. UV light triggers oxidative stress, producing a large number of matrix metalloproteinases and degrading the extracellular matrix in skin cells, thereby causing a series of photoaging symptoms. Concentrated growth factor (CGF) is a leukocyte- and platelet-rich fibrin biomaterial that plays a protective role in the occurrence and development of skin photoaging. Read More

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http://dx.doi.org/10.1042/BSR20193566DOI Listing

Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia.

Microscopy (Oxf) 2020 Jul 6. Epub 2020 Jul 6.

Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8521, Japan.

G-protein-coupled receptors (GPCRs) comprise the largest and most diverse cell surface receptor family, with more than 800 known GPCRs identified in the human genome. Binding of an extracellular cue to a GPCR results in intracellular G protein activation, after which a sequence of events can be amplified and optimized by selective binding partners and downstream effectors in spatially discrete cellular environments. Because GPCRs are widely expressed in the body, they help to regulate an incredible range of physiological processes from sensation to growth to hormone responses. Read More

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http://dx.doi.org/10.1093/jmicro/dfaa035DOI Listing

Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging.

J Mater Chem B 2020 Jul 6. Epub 2020 Jul 6.

School of Life Science and Technology, Tokyo Institute of Technology, B-50, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. and Research Organization for Nano & Life Innovation, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan.

Three-dimensional (3D) culture is expected to reproduce biological tissues more representatively than monolayer culture, which is important for in vitro research such as drug screening. Recently, various cell culture substrates for spheroid engineering have been developed based on the prevention of cell adhesion. However, despite the expanded usability these substrates provide, they remain limited in terms of optical microscopy imaging of spheroids with high magnification lenses. Read More

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http://dx.doi.org/10.1039/d0tb00723dDOI Listing

Perfluorocarbon nanodroplets stabilized with cisplatin-prodrug-constructed lipids enable efficient tumor oxygenation and chemo-radiotherapy of cancer.

Nanoscale 2020 Jul 6. Epub 2020 Jul 6.

Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, P.R. China.

Concurrent chemo-radiotherapy has been widely applied for the treatment of a wide range of cancers, but its therapeutic efficacy against most solid tumors is severely impaired by their intrinsic hypoxic microenvironments. Utilizing the high oxygen loading capacity of perfluoro-15-crown-5-ether (PFCE), herein, we prepare PFCE nanodroplets with cisplatin prodrug (cisPt(iv)) conjugated phospholipids and other commercial lipids as the stabilizer to enable tumor targeted oxygen shuttling. The obtained PFCE@cisPt(iv)-Lip shows high physiological stability and efficient oxygen loading capacity. Read More

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http://dx.doi.org/10.1039/d0nr01476aDOI Listing

Orobol, a derivative of genistein, inhibits heat-killed -induced inflammation in HaCaT keratinocytes.

J Microbiol Biotechnol 2020 Jun 22. Epub 2020 Jun 22.

Biomodulation Major and Research Institute of Agriculture and Life Sciences, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.

Acne is a chronic skin disease that typically occurs in the teens and twenties, and its symptoms vary according to age, sex, diet, and lifestyle. Acne is characterized by hyperproliferation of keratinocytes in the epidermis, sebum overproduction, growth of , and induced skin inflammation. Interleukin (IL)-1α and IL-6 are predominant in the inflammatory lesions of acne vulgaris. Read More

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http://dx.doi.org/10.4014/jmb.2003.03063DOI Listing

A proposed carbon-utilization and virulence protein A, CuvA (Rv1422), from Mycobacterium tuberculosis H37Rv: crystallization, X-ray diffraction analysis and ligand binding.

Acta Crystallogr F Struct Biol Commun 2020 Jul 1;76(Pt 7):314-319. Epub 2020 Jul 1.

Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea.

Mycobacterium tuberculosis possesses the ability to undergo physiological adaptations in order to persist during the prolonged course of infection despite the active immune response of the host and in order to overcome multiple environmental changes. Previous studies have proposed that M. tuberculosis CuvA (Rv1422; MtCuvA) might play a critical role in the adaptation of the bacterium to environmental changes, such as nutrient utilization and alteration of the growth rate. Read More

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http://dx.doi.org/10.1107/S2053230X20008626DOI Listing

Design and screening of FAK, CDK 4/6 dual inhibitors by pharmacophore model, molecular docking, and molecular dynamics simulation.

J Biomol Struct Dyn 2020 Jul 6:1-10. Epub 2020 Jul 6.

College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China.

Focal adhesion kinase (FAK) is one kind of tyrosine kinases that modulates integrin and growth factor signaling pathways, which is a promising therapeutic target because of involving in the migration, proliferation and survival of cancer cell. Overexpression and amplification of cyclin-dependent kinase 4/6 (CDK4/6) occur in many cancers and may be the cause of resistance to CDK4/6 inhibitors in preclinical models. The latest research shows that the combination of FAK and CDK4/6 can be dually targeted to enhance the antitumor effects. Read More

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http://dx.doi.org/10.1080/07391102.2020.1786458DOI Listing

Regulation and repurposing of nutrient sensing and autophagy in innate immunity.

Autophagy 2020 Jul 5:1-21. Epub 2020 Jul 5.

Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London , London, UK.

Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is activated by amino acids and growth factors, and AMP-activated protein kinase (AMPK), which is activated by low levels of glucose or ATP. Read More

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http://dx.doi.org/10.1080/15548627.2020.1783119DOI Listing

upregulation suppresses autophagy and accelerates malignant phenotype in nasopharyngeal carcinoma.

Autophagy 2020 Jul 5:1-17. Epub 2020 Jul 5.

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University , Nantong, Jiangsu Province, China.

Dysregulated microRNAs (miRNAs) are involved in carcinoma progression, metastasis, and poor prognosis. We demonstrated that in nasopharyngeal carcinoma (NPC), transactivated promotes a malignant phenotype by functioning as a macroautophagy/autophagy suppressor by targeting (BTG anti-proliferation factor 3) and activating autophagy-regulating MAPK signaling. expression was markedly increased in NPC cases based on quantitative real-time PCR, miRNA microarray, and TCGA database analysis findings. Read More

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http://dx.doi.org/10.1080/15548627.2020.1781368DOI Listing

Marijuana Use for Women: To Prescribe or Not to Prescribe.

Subst Use Misuse 2020 Jul 5:1-2. Epub 2020 Jul 5.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The marijuana policy varies greatly worldwide. Marijuana use is illegal in most countries. Nevertheless, the medical potentials of marijuana have been increasingly uncovered, and its use by women is increasing. Read More

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http://dx.doi.org/10.1080/10826084.2020.1782938DOI Listing

[Thermosensitive gel of polysaccharide from Ganoderma applanatum combined with paclitaxel for mice with 4T1 breast cancer].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2533-2539

College of Pharmacy,Zhejiang University of Technology Hangzhou 310014,China.

Polysaccharide from Ganoderma applanatum has the activities of anti-tumor and enhancing immune function. There were no reports on antitumor effect of its intratumoral injection. In this study, the polysaccharide was extracted from G. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200328.304DOI Listing

[Mechanism of psoralen in aggravating hepatotoxicity induced by CCl_4 by delaying liver regeneration].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2916-2923

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University Guangdong 510006, China Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University Nanjing 210009, China.

This study aimed to investigate whether psoralen can aggravate hepatotoxicity induced by carbon tetrachloride(CCl_4) by inducing hepatocyte cycle arrest and delaying liver regeneration. Female C57 BL/6 mice aged 6-8 weeks were randomly divided into control group, model group(CCl_4 group), combined group(CCl_4+PSO group) and psoralen group(PSO group). CCl_4 group and CCl_4+PSO group were given CCl_4 intraperitoneally at a dose of 100 μL·kg~(-1) once; olive oil of the same volume was given to control group and PSO group intraperitoneally; 12 h, 36 h and 60 h after CCl_4 injection, PSO group and CCl_4+PSO group were administrated with PSO intragastrically at a dose of 200 mg·kg~(-1); 0. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200115.401DOI Listing

[Advances on anti-tumor mechanisms of zerumbone].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2817-2826

School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.

Zerumbone(ZER), one of humulane-type sesquiterpenoids, showed its unique advantage against tumor activities. The main underlying mechanisms include inhibiting the growth and proliferation of cancer cells, inducing apoptosis of cancer cells and differentiation of cancer cells, regulating immune function, inhibiting invasion and metastasis of cancer cells, and reversing multidrug resistance of cancer cells. Studies on ZER focusing its cytotoxic or anti-tumor is one of hot topic. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200217.401DOI Listing

Glucose uptake to guard cells via STP transporters provides carbon sources for stomatal opening and plant growth.

EMBO Rep 2020 Jul 6:e49719. Epub 2020 Jul 6.

Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland.

Guard cells on the leaf epidermis regulate stomatal opening for gas exchange between plants and the atmosphere, allowing a balance between photosynthesis and transpiration. Given that guard cells possess several characteristics of sink tissues, their metabolic activities should largely depend on mesophyll-derived sugars. Early biochemical studies revealed sugar uptake into guard cells. Read More

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http://dx.doi.org/10.15252/embr.201949719DOI Listing

Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells in vitro and in vivo.

Oncol Rep 2020 Jul 7;44(1):339-348. Epub 2020 May 7.

Department of Gastroenterology and Neurology, Kagawa University, Takamatsu, Kagawa 761‑0793, Japan.

Gastric cancer is one of the most common malignancies diagnosed worldwide. Telmisartan, an angiotensin receptor blocker (ARB), suppresses the proliferation of cancer cells and the growth of tumors through an unknown mechanism. To identify the mechanism, the present study was designed to evaluate the effects of telmisartan on gastric cancer cell lines and tumors in vitro and in vivo and the associated signaling molecules were identified. Read More

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http://dx.doi.org/10.3892/or.2020.7607DOI Listing

Proline‑rich polypeptide‑1 decreases cancer stem cell population by targeting BAFF chromatin‑remodeling complexes in human chondrosarcoma JJ012 cells.

Oncol Rep 2020 Jul 14;44(1):393-403. Epub 2020 May 14.

Department of Orthopaedics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.

Chondrosarcoma is the second most common primary malignant bone tumor and is resistant to chemotherapy and radiation. Inadequate treatment response and poor prognosis requires novel therapeutic approaches. Proline‑rich polypeptide‑1 (PRP‑1), synthesized by brain neurosecretory cells, has demonstrated antitumor properties in JJ012‑cells; however, its underlying molecular mechanism remains unclear. Read More

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http://dx.doi.org/10.3892/or.2020.7612DOI Listing
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