6,977,108 results match your criteria Cell cycle Georgetown Tex.[Journal]

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The BCL-2 family protein inhibitor ABT-737 as an additional tool for the treatment of EBV-associated post-transplant lymphoproliferative disorders.

Mol Oncol 2020 Jul 4. Epub 2020 Jul 4.

UMR 8126, CNRS, Université Paris-Saclay, Institut Gustave Roussy, 94805, Villejuif, France.

Post-transplant lymphoproliferative disorders (PTLD) and Burkitt lymphoma (BL) are B-cell malignancies strongly associated with Epstein-Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression of the anti-apoptotic protein BCL-2. Given its chemoprotective effect, BCL-2 constitutes an attractive target for new therapeutic strategies for EBV-positive B-cell malignancies. Read More

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http://dx.doi.org/10.1002/1878-0261.12759DOI Listing

Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155.

IUBMB Life 2020 Jul 4. Epub 2020 Jul 4.

Department of Breast and Thyroid Surgery, Jining No. 1 People's Hospital, Jining, Shandong, China.

Aims: Schizandrin A (SchA) is a type of lignan with biological properties against oxidation, inflammation, and cancer. Here, we aimed to sustain the bioactive properties of SchA in proliferative and motional phenotypes of MDA-MB-231 cells and their molecular mechanism.

Methods: MDA-MB-231 cells were exposed to SchA. Read More

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http://dx.doi.org/10.1002/iub.2329DOI Listing

Establishment of a Mouse Model for Post-Inflammatory Hyperpigmentation.

Pigment Cell Melanoma Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, Yamagata University, Faculty of Medicine, Yamagata, Japan.

Post-inflammatory hyperpigmentation (PIH) is a common cutaneous condition that can cause a disfigured appearance. However, the pathophysiology of PIH remains poorly understood, at least in part, because an appropriate animal model for research has not been established. In order to analyze the pathomechanism of PIH, we successfully induced PIH in a hairless version of transgenic mice (hk14-SCF Tg/HRM) that have a human-type epidermis containing melanin by repeated hapten application of 2,4-dinitrofluorobenzene. Read More

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http://dx.doi.org/10.1111/pcmr.12911DOI Listing

Nuclear staining of claudin-18 is a new immunohistochemical marker for diagnosing intramucosal well-differentiated gastric adenocarcinoma.

Pathol Int 2020 Jul 5. Epub 2020 Jul 5.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Diagnosis of gastric adenocarcinoma using small biopsy samples is occasionally difficult. Various markers have been employed for improving the diagnostic accuracy, but there remains room for improvement. A total of 129 endoscopically biopsied samples were studied, consisting of 104 intramucosal tubular adenocarcinomas, 24 non-cancerous lesions and one cancer sample originally suspected of non-cancer but revised as cancer after immunostaining. Read More

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http://dx.doi.org/10.1111/pin.12978DOI Listing

Survival Following Cytoreductive Nephrectomy: A Comparison of Existing Prognostic Models.

BJU Int 2020 Jul 4. Epub 2020 Jul 4.

The University of Texas, M.D. Anderson Cancer Center, Department of Urology, USA.

Objective: To validate models currently used to predict metastatic renal cell carcinoma (mRCC) outcomes in a cohort of patients undergoing cytoreductive nephrectomy (CN).

Patients And Methods: Ten renal cell carcinoma (RCC) prognostic models (International Metastatic RCC Database Consortium [IMDC]; Memorial Sloan Kettering Cancer Center [MSKCC]; Culp; Leibovich; University of California at Los Angeles Integrated Staging System [UISS]; Stage, Size, Grade, and Necrosis [SSIGN]; Yaycioglu; Karakiewicz; Cindolo; and Margulis) were chosen based on clinical relevance and use in clinical trial design. Model validation was performed using patients who underwent CN at a single institution between 2005 and 2017 and model discrimination (ability to select patients at risk of death) was assessed. Read More

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http://dx.doi.org/10.1111/bju.15160DOI Listing

Adhesive pads of gecko and anoline lizards utilize corneous and cytoskeletal proteins for setae development and renewal.

Authors:
Lorenzo Alibardi

J Exp Zool B Mol Dev Evol 2020 Jul 5. Epub 2020 Jul 5.

Comparative Histolab Padova and Department of Biology, University of Bologna, Bologna, Italy.

The formation of the complex pattern of setae in adhesive pads of geckos and anoline lizards has been analyzed by ultrastructural, autoradiographic, and immunohistochemical methods. Setae terminate with spatulated ends responsible for adhesion that allow these lizards to climb vertical substrates and conquer arboreal niches. Setae derive from a complex interfaced molding between two specialized epidermal layers of the shedding complex that determines the cyclical skin molting, Oberhautchen and clear layers. Read More

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http://dx.doi.org/10.1002/jez.b.22976DOI Listing

Facial rejuvenation using stem cell conditioned media combined with skin needling: A split face comparative study.

J Cosmet Dermatol 2020 Jul 5. Epub 2020 Jul 5.

Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt.

Background: The use of stem cells derived growth factors is representing a novel treatment modality in facial rejuvenation. Nowadays, skin needling is considered a very famous treatment of skin aging. However, the addition of such derived products, augments it's therapeutic efficacy in the management and delay of skin aging. Read More

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http://dx.doi.org/10.1111/jocd.13594DOI Listing

Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity.

Am J Reprod Immunol 2020 Jul 4:e13298. Epub 2020 Jul 4.

Department of Clinical Microbiology/Infection and Immunology, Umeå University, Umeå, Sweden.

Problem: Endometriosis is a disease characterized by ectopic implantation of endometrium and impaired immune responses. To explore its pathogenic mechanisms, we studied the local and systemic cytokine mRNA profiles and their role in the immunity of patients with endometriosis and healthy controls.

Method Of Study: mRNA for eleven cytokines defining cytotoxic Th1, humoral Th2, regulatory Tr1/Th3 and inflammatory cytokine profiles were characterized locally in endometriotic tissue and endometrium, and systemically in PBMCs from women with endometriosis and healthy controls, using real-time qRT-PCR. Read More

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http://dx.doi.org/10.1111/aji.13298DOI Listing

How far is single-cell sequencing from clinical application?

Clin Transl Med 2020 Jul 5. Epub 2020 Jul 5.

Department of Pulmonary and Critical Care Medicine, Clinical Center for Molecular Diagnosis and Therapy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.

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http://dx.doi.org/10.1002/ctm2.117DOI Listing

Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.

FASEB J 2020 Jul 5. Epub 2020 Jul 5.

Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

The majority of anti-cancer therapies target the proliferating tumor cells, while the tumor stroma, principally unaffected, survives, and provide a niche for surviving tumor cells. Combining tumor cell and stroma-targeting therapies thus have a potential to improve patient outcome. The neuroblastoma stroma contains cancer-associated fibroblasts expressing microsomal prostaglandin E synthase-1 (mPGES-1). Read More

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http://dx.doi.org/10.1096/fj.202000684RDOI Listing

Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway.

FASEB J 2020 Jul 5. Epub 2020 Jul 5.

Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, P.R. China.

Blood-brain tumor barrier (BTB) severely restricts the efficient delivery of chemotherapeutic drugs into brain tumor tissue, which is a critical obstacle for glioma treatment. Recently, long noncoding RNAs (lncRNAs) have shown as regulation factors of numerous biological processes. In this study, we identified that Lnc00462717 was upregulated in glioma endothelial cells (GECs), and that knockdown of Lnc00462717 significantly increased the BTB permeability. Read More

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http://dx.doi.org/10.1096/fj.202000045RDOI Listing

Biallelic loss-of-function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth.

Hum Mutat 2020 Jul 5. Epub 2020 Jul 5.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.

The family of Tre2-Bub2-Cdc16 (TBC)-domain containing GTPase activating proteins (RABGAPs) are not only known as key regulators of RAB GTPase activity, but also has GAP-independent functions. RAB GTPases are implicated in membrane trafficking pathways, such as vesicular trafficking. We report biallelic loss-of-function variants in TBC1D2B, encoding a member of the TBC/RABGAP family with yet unknown function, as the underlying cause of cognitive impairment, seizures, and/or gingival overgrowth in three individuals from unrelated families. Read More

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http://dx.doi.org/10.1002/humu.24071DOI Listing

Functional analysis of Dicer-2 gene in Bombyx mori resistance to BmNPV virus.

Arch Insect Biochem Physiol 2020 Jul 5:e21724. Epub 2020 Jul 5.

School of Life Science, Anhui Agricultural University, Hefei, China.

Bombyx mori nucleopolyhedrovirus (BmNPV) is a primary pathogen in silkworm, and the molecular mechanism of B. mori defense to BmNPV infection is still unclear. RNA interference (RNAi) is well-known as an intracellular conserved mechanism that is critical in gene regulation and cell defense. Read More

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http://dx.doi.org/10.1002/arch.21724DOI Listing

Delta opioid receptor activation modulates affective pain and modality-specific pain hypersensitivity associated with chronic neuropathic pain.

J Neurosci Res 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychology and Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

Delta opioid receptor (DOR) agonists alleviate nociceptive behaviors in various chronic pain models, including neuropathic pain, while having minimal effect on sensory thresholds in the absence of injury. The mechanisms underlying nerve injury-induced enhancement of DOR function are unclear. We used a peripheral nerve injury (PNI) model of neuropathic pain to assess changes in the function and localization of DORs in mice and rats. Read More

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http://dx.doi.org/10.1002/jnr.24680DOI Listing

Chemical composition and antimicrobial activity of cuticular and internal lipids of the insect Rhynchophorus palmarum.

Arch Insect Biochem Physiol 2020 Jul 5:e21723. Epub 2020 Jul 5.

Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, Alagoas, Brazil.

Insect cuticle lipids are involved in various types of chemical communication between species, and reduce the penetration of insecticides, chemicals, and toxins, as well as provide protection against the attack of microorganisms, parasitic insects, and predators. Ecological studies related to the insect Rhynchophorus palmarum are well-known; however, very little is known about its resistance mechanisms, which includes its lipid composition and its importance, specifically the cuticle layer. This study aimed to characterize the cuticle and internal lipid compounds of the male and female R. Read More

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http://dx.doi.org/10.1002/arch.21723DOI Listing

Detecting pathogenic variants in autoimmune diseases using high-throughput sequencing.

Authors:
Matt A Field

Immunol Cell Biol 2020 Jul 5. Epub 2020 Jul 5.

Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.

Sequencing the first human genome in 2003 took 15 years and cost $2.7 billion. Advances in sequencing technologies have since decreased costs to the point where it is now feasible to re-sequence a whole human genome for $1000 in a single day. Read More

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http://dx.doi.org/10.1111/imcb.12372DOI Listing

Methyl aminolevulinate photodynamic therapy for Bowen's disease on the fingers - Is monotherapy sufficiently effective?

Photodermatol Photoimmunol Photomed 2020 Jul 5. Epub 2020 Jul 5.

Medical University of Graz, Department of Dermatology and Venereology.

Bowen's disease (BD), also known as squamous cell carcinoma (SCC) in situ, most commonly involves the head and neck area as well as the extremities (1), but little epidemiological data exists about its prevalence on the fingers. Several treatment modalities are available for BD, including surgical excision, photodynamic therapy (PDT), topical 5-fluorouracil, imiquimod, and cryotherapy, but no single therapy has been proven to be superior to others.(2) Several case reports have previously shown that PDT may be an effective treatment for BD on the fingers. Read More

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http://dx.doi.org/10.1111/phpp.12586DOI Listing

IGFBP5 enhances the dentinogenesis potential of dental pulp stem cells via JNK and ErK signaling pathways.

J Oral Rehabil 2020 Jul 5. Epub 2020 Jul 5.

Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.

Background: Dental Stem cell transplantation has become a new method for tooth tissue regeneration. However, its molecular mechanism of the dentinogenic differentiation is still unclear, limited its application. Our previous studies found that Insulin-like growth factor binding protein 5 (IGFBP5) can promote the osteogenic differentiation of periodontal ligament stem cells and the regeneration of periodontal tissues. Read More

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http://dx.doi.org/10.1111/joor.13047DOI Listing

Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life.

Clin Exp Allergy 2020 Jul 5. Epub 2020 Jul 5.

Division of Pediatric Pulmonary and Sleep Medicine. Children's National Medical Center, George Washington University, Washington, D.C, USA.

Introduction: IFN-lambda (type III-IFN-λ1) is a molecule primarily produced by epithelial cells that provides an important first-line defense against viral respiratory infections and has been linked to the pathogenesis of viral induced wheezing in early life. The goal of this study was to better understand the regulation of innate IFN-lambda responses in vitro in primary human infant airway epithelial cells (AECs) and in vivo using nasal aspirates during viral respiratory infections.

Methods: IFN-lambda protein levels were quantified: I) in human infant AECs exposed to (poly(I:C) dsRNA) under different experimental conditions (n=8 donors); and II) in nasal aspirates of young children (≤3 years) hospitalized with viral respiratory infection (n=138) and in uninfected controls (n= 74). Read More

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http://dx.doi.org/10.1111/cea.13701DOI Listing

Possible mechanisms for generation of phenyl-glycoside-type lignin-carbohydrate linkages in lignification with monolignol glucosides.

Plant J 2020 Jul 4. Epub 2020 Jul 4.

Graduate School of Agriculture, Kyoto University, Kitashirakawa-oiwakecho, Kyoto, 606-8502, Japan.

The existence and formation of covalent lignin-carbohydrate (LC) linkages in plant cell walls has long been a matter of debate in terms of their roles in cell wall development and biomass utilization. Of the various putative LC linkages proposed to date, evidence of the native existence and formation mechanism of phenyl-glycoside (PG)-type LC linkages in planta is particularly scarce. The present study aimed to explore previously overlooked mechanisms for the formation of PG-type LC linkages through incorporation of monolignol glucosides, which are possible lignin precursors, into lignin polymers during lignification. Read More

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http://dx.doi.org/10.1111/tpj.14913DOI Listing

A case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse Large B-cell Lymhpoma with immature features or B-cell Lymhpoblastic Lymphoma?

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Oncology and Hematology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Primary cutaneous B-cell lymphomas are a heterogeneous group of lymphoid neoplasms primarily occurring in the skin. Although most cases are represented by primary cutaneous follicle center cell lymphoma, primary cutaneous marginal zone lymphoma and leg-type diffuse large B-cell lymphoma, other diffuse large B-cell lymphomas and B-cell lymphoblastic lymphoma may rarely present primarily in the skin. In this setting, the presence of histopathologic and immunohistochemical features of cellular immaturity is exceedingly rare and may represent a diagnostic challenge. Read More

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http://dx.doi.org/10.1111/cup.13795DOI Listing

Hemocyte-specific FREP13 abrogates the exogenous bacterial population in the hemolymph and promotes midgut endosymbionts in Anopheles stephensi.

Immunol Cell Biol 2020 Jul 5. Epub 2020 Jul 5.

Laboratory of Host-Parasite Interaction Studies, ICMR-National Institute of Malaria Research, Dwarka, New Delhi, 110077, India.

The mosquito's immune blood cells, 'hemocytes' imparts a highly selective immune response against various micro-organisms/pathogens. Among several immune effectors, FREPs (Fibrinogen related proteins) have been recognized as key modulator of cellular immune responses; however, their physiological relevance has not been investigated in detail. Our ongoing comparative RNA-Seq analysis identified a total of 13 FREPs originating from naïve sugar-fed, blood-fed, bacterial challenged, and Plasmodium vivax-infected hemocytes in the mosquito Anopheles stephensi hemocytes. Read More

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http://dx.doi.org/10.1111/imcb.12374DOI Listing

Brucella abortus-infected platelets modulate activation of neutrophils.

Immunol Cell Biol 2020 Jul 5. Epub 2020 Jul 5.

Instituto de Medicina Experimental (CONICET-Academia Nacional de Medicina), Buenos Aires, Argentina.

Brucellosis is a contagious disease caused by bacteria of the genus Brucella. Platelets have been widely involved in the modulation of the immune response. We have previously reported the modulation of Brucella abortus-mediated infection of monocytes. Read More

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http://dx.doi.org/10.1111/imcb.12373DOI Listing

Ultrastructural investigation of acidocalcisomes and ATPase activity in yeasts Candida guillermondii NP-4 as "complementary" stress-targets.

Lett Appl Microbiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Biochemistry, Microbiology and Biotechnology, Yerevan State University, 1 A. Manoogyan Str, 0025, Yerevan, Armenia.

As a result of electron microscopic studies of morphogenesis in yeasts Candida guilliermondii NP-4, the formation of new structures of volutin acidocalcisomes has been established within the cell cytoplasm. Under influence of X-irradiation the changes in morphometric and electron-dense properties of yeast cells were identified: in yeast cytoplasm, the electron-dense volutin granules were increased up to 400 nm in size. After 24 h post-irradiation incubation of yeasts the large volutin pellets are fragmented into smaller number particles in size up to 25-150 nm. Read More

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http://dx.doi.org/10.1111/lam.13348DOI Listing

Enhanced cytokine expression and upregulation of inflammatory signaling pathways in broiler chickens affected by wooden breast myopathy.

J Sci Food Agric 2020 Jul 5. Epub 2020 Jul 5.

College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Joint International Research Laboratory of Animal Health and Food Safety, National Experimental Teaching Demonstration Center of Animal Science, Nanjing Agricultural University, Nanjing, 210095, P.R. China.

Background: Wooden breast (WB) myopathy in broiler chickens is a growing challenge for the poultry industry. Previous multi-omic data have implied that the pathogenesis of WB is associated with the activation of immune system and inflammatory response. However, the intricate mechanisms are not fully understood. Read More

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http://dx.doi.org/10.1002/jsfa.10641DOI Listing

Trichoblastic carcinosarcoma with panfollicular differentiation (panfollicular carcinosarcoma) and CTNNB1 (beta-catenin) mutation.

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.

We present a case of trichoblastic carcinosarcoma with panfollicular differentiation. An 80-year-old man presented with a lesion on the left ear which had been present for several months. Histopathology revealed a well-demarcated neoplasm in the dermis composed of intimately intermingled malignant epithelial and mesenchymal cells. Read More

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http://dx.doi.org/10.1111/cup.13794DOI Listing

Monte Carlo dosimetry of a realistic multicellular model of follicular lymphoma in a context of radioimmunotherapy.

Med Phys 2020 Jul 4. Epub 2020 Jul 4.

CRCT, UMR 1037 INSERM, Université Paul Sabatier, F-31037, Toulouse, France.

Purpose: Tumors geometry and radiopharmaceutical biodistribution impact the energy deposition in targeted radionuclide therapy. However, small-scale dosimetry studies generally consider an artificial environment where the tumors are spherical and the radionuclides are homogeneously biodistributed. To bring realism, we developed a dosimetric methodology based on a three-dimensional in vitro model of follicular lymphoma incubated with rituximab, an anti-CD20 monoclonal antibody used in the treatment of non-Hodgkin lymphomas, which might be combined with a radionuclide. Read More

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http://dx.doi.org/10.1002/mp.14370DOI Listing

Aromatase deficiency: a case series of 46, XX Chinese children and a systematic review of the literature.

Clin Endocrinol (Oxf) 2020 Jul 5. Epub 2020 Jul 5.

Department of Endocrinology, Genetics, Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion.

Objective: To investigate the clinical characteristics and accurate management of aromatase-deficient children.

Patients And Methods: We described three 46, XX aromatase-deficient children, searched PubMed with "(aromatase deficiency) AND (46, XX OR ovaries)" and manually searched citations in identified studies for the literature review. Read More

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http://dx.doi.org/10.1111/cen.14277DOI Listing

Generation of functional lungs with pluripotent stem cells.

Allergy 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario "A Gemelli" - IRCCS, University of the Sacred Heart. Rome, Italy.

Millions of people of all ages suffer from chronic respiratory diseases (CRDs), including asthma, respiratory allergies and chronic obstructive pulmonary disease. To date, although significant advances have been made in terms of treatment, end-stage CRDs still remains one of the most frequent causes of death worldwide with a death rate that has been increasing over the past few years. Lung transplantation is the only therapeutic option when other treatments fail. Read More

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http://dx.doi.org/10.1111/all.14485DOI Listing

Fluoride Absorption, Transportation and Tolerance Mechanism in Camellia sinensis, and Its Bioavailability and Health Risk Assessment: a Systematic Review.

J Sci Food Agric 2020 Jul 5. Epub 2020 Jul 5.

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, 230036, Anhui, People's Republic of China.

Tea is the one of the most popular nonalcoholic caffeinated beverages in the world. Tea is produced from the tea plant (Camellia sinensis (L.) O. Read More

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http://dx.doi.org/10.1002/jsfa.10640DOI Listing

Neonatal Bladder-derived Mesenchymal Stem Cells Ameliorate Bladder Dysfunction in Diabetic Rat Models.

Urol J 2020 Jun 23;17(4):413-421. Epub 2020 Jun 23.

Department of Urology, Ufuk University, School of Medicine, Ankara, Turkey.

Purpose: To evaluate the effect of a new mesenchymal stem cell type derived from the neonatal bladder (nMSC-B) on diabetic bladder dysfunction (DBD).

Materials And Methods: nMSC-B were harvested from neonatal male Sprague-Dawley rat's bladder and expanded in culture. nMSC-B were transferred to Type-1 diabetic rats which were induced by a single dose 45 mg/kg Streptozocin (STZ). Read More

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http://dx.doi.org/10.22037/uj.v0i0.5504DOI Listing

The relationship between the presence of HPV infection and biofilm formation in cervicovaginal smears.

Infection 2020 Jul 4. Epub 2020 Jul 4.

Department of Gynecology and Obstetrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: To demonstrate and understand the association of HPV infection and biofilm formation.

Methods: The study consisted of cervicovaginal samples of 72 women who were evaluated at the colposcopy unit. Papanicolaou staining was used for cytological examination while "Crystal Violet Binding" assay was performed to detect biofilm formation. Read More

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http://dx.doi.org/10.1007/s15010-020-01478-5DOI Listing

Danlou Tablet () Improves Chronic Intermittent Hypoxia-induced Dyslipidemia and Arteriosclerosis by HIF-1 α-Angptl4 mRNA Signaling Pathway.

Chin J Integr Med 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Objective: To detect whether Danlou Tablet (, DLT) regulates the hypoxia-induced factor (HIF)-1 α-angiopoietin-like 4 (Angptl4) mRNA signaling pathway and explore the role of DLT in treating chronic intermittent hypoxia (CIH)-induced dyslipidemia and arteriosclerosis.

Methods: The mature adipocytes were obtained from 3T3-L1 cell culturation and allocated into 8 groups including control groups (Groups 1 and 5, 0.1 mL of cell culture grade water); DLT groups (Groups 2 and 6, 0. Read More

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http://dx.doi.org/10.1007/s11655-020-3255-8DOI Listing

Role of the bone microenvironment in bone metastasis of malignant tumors - therapeutic implications.

Authors:
Xiaoting Ma Jing Yu

Cell Oncol (Dordr) 2020 Jul 4. Epub 2020 Jul 4.

Cancer Center, Beijing Friendship Hospital, Capital Medical University, No.95 Yong An Road, Xi Cheng District, Beijing, 100050, China.

Background: Bone is one of the most common sites for solid tumor metastasis. Bone metastasis of a malignant tumor seriously affects the quality of life and the overall survival of patients. Evidence has suggested that bone provides a favorable microenvironment that enables disseminated tumor cells to home, proliferate and colonize, leading to the formation of metastases. Read More

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http://dx.doi.org/10.1007/s13402-020-00512-wDOI Listing

Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation.

Cell Oncol (Dordr) 2020 Jul 4. Epub 2020 Jul 4.

Liver Disease Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No.528. Zhangheng Road, Pudong New District, Shanghai, People's Republic of China.

Purpose: Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), which has a male predominance, lacks effective therapeutic options. Previously, the cardiac glycoside analogue bufalin has been found to inhibit HBV infection and HCC development. As yet, however, its molecular role in HBV-associated HCC has remained obscure. Read More

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http://dx.doi.org/10.1007/s13402-020-00546-0DOI Listing

Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγ.

Cell Biol Toxicol 2020 Jul 4. Epub 2020 Jul 4.

Department of Toxicology, Shaanxi Key Lab of Free Radical Biology and Medicine, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University (Fourth Military Medical University), Changle West Road 169, Xi'an, 710032, Shaanxi Province, China.

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) associated with non-alcoholic fatty liver disease (NAFLD). The effects of gestational BPA exposure on hepatic lipid accumulation in offspring are not fully understood. Here, we investigate the sex-dependent effects of gestational BPA exposure on hepatic lipid and glucose metabolism in the offspring of mice to reveal the mechanisms underlying gestational BPA exposure-associated NAFLD. Read More

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http://dx.doi.org/10.1007/s10565-020-09535-3DOI Listing

Distinct requirements for budding yeast Rev1 and Polη in translesion DNA synthesis across different types of DNA damage.

Authors:
Zihao Wang Wei Xiao

Curr Genet 2020 Jul 4. Epub 2020 Jul 4.

Beijing Key Laboratory of DNA Damage Responses and College of Life Sciences, Capital Normal University, Beijing, 100048, China.

Certain replication-blocking lesions can escape DNA repair and must be bypassed to prevent fork collapse and cell death. Budding yeast DNA-damage tolerance consists of translesion DNA synthesis (TLS) and template switch. TLS utilizes specialized DNA polymerases to insert nucleotides opposite the damage site, followed by extension, allowing continual replication in the presence of lesions on the template DNA. Read More

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http://dx.doi.org/10.1007/s00294-020-01092-wDOI Listing

Aβ40 Oligomers Promote Survival and Early Neuronal Differentiation of Dentate Gyrus-Isolated Precursor Cells Through Activation of the Akt Signaling Pathway.

Neurotox Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV-IPN), Av. Instituto Politécnico Nacional 2508, 07360, Mexico City, Mexico.

The amyloid beta-peptide (Aβ) is the low-abundance product of amyloid precursor protein (APP), which is produced lifelong in the healthy brain. The functional properties of Aβ40 and Aβ42 peptides have not been completely elucidated to date. Although, several studies suggest that these peptides have a number of neurotrophic and neurotoxic properties, respectively. Read More

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http://dx.doi.org/10.1007/s12640-020-00253-6DOI Listing

Association of genetic polymorphism of BCL-2 (rs2279115) with susceptibility to HCV-related hepatocellular carcinoma.

Immunol Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Hepatitis C virus (HCV) infection is the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). B cell lymphoma-2 (BCL-2) prevents apoptosis, and its overexpression could promote cancer cell survival. The purpose of this study is to evaluate the association of Bcl-2 gene polymorphism (rs2279115) and HCV-related HCC susceptibility. Read More

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http://dx.doi.org/10.1007/s12026-020-09143-7DOI Listing

The effects of a short-term exposure to propiconazole in zebrafish (Danio rerio) embryos.

Environ Sci Pollut Res Int 2020 Jul 4. Epub 2020 Jul 4.

Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.

Propiconazole (PCZ) is a widely used fungicide around the world and was frequently detected in surface waters, which would pose risk to aquatic organisms. Previous studies indicated that PCZ has high toxicity to different kinds of fish. However, most of the studies focus on the toxicity and mechanisms of PCZ to adult fish, the potential toxicity mechanism of PCZ to fish embryos is still poorly understood. Read More

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http://dx.doi.org/10.1007/s11356-020-09968-7DOI Listing

β-Asarone Exerts Antioxidative Effects on HO-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway.

Neurochem Res 2020 Jul 4. Epub 2020 Jul 4.

College of Traditional Chinese Medicine·College of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Oxidative stress-mediated neuron damage is considered an important contributor to the pathogenesis and development of neurodegenerative diseases. Although β-asarone is widely known for its neuroprotective pharmacological properties, the exact mechanism of β-asarone against oxidative stress has not been fully elucidated. The aim of the present study was to investigate underlying mechanisms of β-asarone against oxidative damage in PC12 cells. Read More

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http://dx.doi.org/10.1007/s11064-020-03060-9DOI Listing

Rosistilla oblonga gen. nov., sp. nov. and Rosistilla carotiformis sp. nov., isolated from biotic or abiotic surfaces in Northern Germany, Mallorca, Spain and California, USA.

Antonie Van Leeuwenhoek 2020 Jul 4. Epub 2020 Jul 4.

Department of Microbial Interactions, Friedrich Schiller University, Jena, Germany.

Planctomycetes are ubiquitous bacteria with fascinating cell biological features. Strains available as axenic cultures in most cases have been isolated from aquatic environments and serve as a basis to study planctomycetal cell biology and interactions in further detail. As a contribution to the current collection of axenic cultures, here we characterise three closely related strains, Poly24, CA51 and Mal33, which were isolated from the Baltic Sea, the Pacific Ocean and the Mediterranean Sea, respectively. Read More

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http://dx.doi.org/10.1007/s10482-020-01441-2DOI Listing

Association Analysis of ANRIL Polymorphisms and Haplotypes with Autism Spectrum Disorders.

J Mol Neurosci 2020 Jul 5. Epub 2020 Jul 5.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Autism spectrum disorder (ASD) has been shown to have a complex inheritance. Several single-nucleotide polymorphisms (SNPs) have been shown to be associated with risk of this neurodevelopmental disorder. In the current study, we genotyped four SNPs in a genomic hotspot for human disorders. Read More

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http://dx.doi.org/10.1007/s12031-020-01657-xDOI Listing

The Role of Arachidonic Acid Metabolism in Myocardial Ischemia-Reperfusion Injury.

Cell Biochem Biophys 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, PR China.

Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia-reperfusion injury (MIRI). However, no effective treatment is currently available for MIRI. To improve the prognosis of people with cardiovascular disease, it is important to research the mechanism of MIRI. Read More

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http://dx.doi.org/10.1007/s12013-020-00928-zDOI Listing

Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial.

Eur J Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Neonatal Intensive Care Unit, Department of Pediatrics, Mansoura University Children's Hospital, Gomhoria Street, Mansoura, 35516, Egypt.

The feasibility of delayed cord clamping (DCC) in preterm infants with placental insufficiency (PI) is questionable. We aimed to study the effect of DCC on stem cell transfusion, hematological parameters, and clinical outcomes in preterm infants born to mothers with PI. Preterm infants, < 34 weeks' gestation, born to mothers with PI were randomized based on the timing of umbilical cord clamping into delayed clamping for 60 s (DCC group) or immediate cord clamping (ICC group) groups at time of birth. Read More

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http://dx.doi.org/10.1007/s00431-020-03730-4DOI Listing

Effect of Iodine and Selenium on Proliferation, Viability, and Oxidative Stress in HTR-8/SVneo Placental Cells.

Biol Trace Elem Res 2020 Jul 5. Epub 2020 Jul 5.

School of Agriculture, Food and Wine, Waite Research Institute, University of Adelaide, Adelaide, SA, 5005, Australia.

Adequate maternal micronutrition is vital for placental formation, fetal growth, and development. Oxidative stress adversely affects placental development and function and an association between deficient placental development, oxidative stress, and micronutrient deficiency has been observed. Selenium and iodine are two essential micronutrients with antioxidant properties. Read More

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http://dx.doi.org/10.1007/s12011-020-02277-7DOI Listing

IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2.

Cytotechnology 2020 Jul 4. Epub 2020 Jul 4.

Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.

Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor that promotes phagocytosis by microglia. However, whether TREM2 is related to the stimulus-dependent phagocytic activity of microglia is unclear. In this study, the primary cultured microglia were stimulated with interferon (IFN)-γ, interleukin (IL)-4, and interleukin (IL)-10, respectively, and their phagocytic activity against microbeads and apoptotic neural stem cells (NSCs) was measured. Read More

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http://dx.doi.org/10.1007/s10616-020-00409-4DOI Listing

Molecular link between dietary fibre, gut microbiota and health.

Mol Biol Rep 2020 Jul 4. Epub 2020 Jul 4.

Division of Animal Nutrition, ICAR-National Dairy Research Institute, Karnal, Haryana, 132001, India.

Natural polysaccharides cellulose, hemicelluloses, inulin etc., galactooligosaccharides (GOS), and fructooligosaccharides (FOS) play a significant role in the improvement of gut microbiota balance and human health. These polysaccharides prevent pathogen adhesion that stimulates the immune system and gut barrier function by servicing as fermentable substrates for the gut microbiota. Read More

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http://dx.doi.org/10.1007/s11033-020-05611-3DOI Listing

Calcium hypochlorite on mouse embryonic fibroblast cells (NIH3T3) in vitro cytotoxicity and genotoxicity: MTT and comet assay.

Mol Biol Rep 2020 Jul 4. Epub 2020 Jul 4.

Department of Medical Biology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Antimicrobial irrigation solutions are widely used under clinical settings. Their effect on dental tissue is a subject of recent research, which aims for a safer irrigant for clinical use. In this regard, here our goal was to evaluate the cytotoxicity and the genotoxicity of calcium hypochlorite (Ca(OCl)) solution, along with NaOCl, on Mouse embryonic fibroblast cells (NIH3T3). Read More

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http://dx.doi.org/10.1007/s11033-020-05624-yDOI Listing
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