269 results match your criteria Cell communication and signaling : CCS[Journal]


Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.

Cell Commun Signal 2020 Jun 25;18(1):102. Epub 2020 Jun 25.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC). Characterization of Wnt effector pathways is key for our understanding of these processes and for developing therapeutic strategies that aim to preserve tissue homeostasis. O-glycosylated cell surface proteins, such as α-dystroglycan (α-DG), mediate cellular adhesion to extracellular matrix components. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00561-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315491PMC

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells.

Cell Commun Signal 2020 Jun 23;18(1):99. Epub 2020 Jun 23.

Department of Biosciences, Bioanalytical Research Laboratories and Molecular Cancer Research and Tumor Immunology, Cancer Cluster Salzburg, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.

Background: Aberrant hedgehog (HH) signaling is implicated in the development of various cancer entities such as medulloblastoma. Activation of GLI transcription factors was revealed as the driving force upon pathway activation. Increased phosphorylation of essential effectors such as Smoothened (SMO) and GLI proteins by kinases including Protein Kinase A, Casein Kinase 1, and Glycogen Synthase Kinase 3 β controls effector activity, stability and processing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00591-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310537PMC

β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes.

Cell Commun Signal 2020 Jun 16;18(1):93. Epub 2020 Jun 16.

Rush University Medical Center, Department of Microbial Pathogens and Immunity, Rush University Medical College, 1735 W. Harrison Street, 614 Cohn, Chicago, IL, 60612, USA.

Background: The Wnt/β-catenin signaling pathway is a prolific regulator of cell-to-cell communication and gene expression. Canonical Wnt/β-catenin signaling involves partnering of β-catenin with members of the TCF/LEF family of transcription factors (TCF1, TCF3, TCF4, LEF1) to regulate gene expression. IL-6 is a key cytokine involved in inflammation and is particularly a hallmark of inflammation in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00565-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296971PMC

Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells.

Cell Commun Signal 2020 Jun 11;18(1):91. Epub 2020 Jun 11.

Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Background: RNF43 and its homolog ZNRF3 are transmembrane E3 ubiquitin ligases frequently mutated in many human cancer types. Their main role relays on the inhibition of canonical Wnt signaling by the negative regulation of frizzled receptors and LRP5/6 co-receptors levels at the plasma membrane. Intracellular RING domains of RNF43/ZNRF3 mediate the key enzymatic activity of these proteins, but the function of the extracellular Protease Associated (PA) fold in the inhibition of Wnt/β-catenin pathway is controversial up-to date, apart from the interaction with secreted antagonists R-spondin family proteins shown by the crystallographic studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00559-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291719PMC

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.

Cell Commun Signal 2020 May 1;18(1):69. Epub 2020 May 1.

Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland.

Fibroblast growth factors (FGFs) via their receptors (FGFRs) transduce signals from the extracellular space to the cell interior, modulating pivotal cellular processes such as cell proliferation, motility, metabolism and death. FGF superfamily includes a group of fibroblast growth factor homologous factors (FHFs), proteins whose function is still largely unknown. Since FHFs lack the signal sequence for secretion and are unable to induce FGFR-dependent cell proliferation, these proteins were considered as intracellular proteins that are not involved in signal transduction via FGFRs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00573-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193404PMC

Unusually persistent Gα-signaling of the neuropeptide Y receptor depletes cellular G pools and leads to a G-refractory state.

Cell Commun Signal 2020 Mar 30;18(1):49. Epub 2020 Mar 30.

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, D-04103, Leipzig, Germany.

Background: A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y receptor (hYR) undergoes ligand dependent activation and internalization into intracellular compartments, followed by recycling to the plasma membrane. This receptor is involved in the pathophysiology of distinct diseases e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00537-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104545PMC

Biology of phosphatidylserine (PS): basic physiology and implications in immunology, infectious disease, and cancer.

Cell Commun Signal 2020 Mar 11;18(1):41. Epub 2020 Mar 11.

Rutgers University, The State University of New Jersey, Newark, New Jersey, USA.

Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restricted to the inner leaflet of the plasma membrane. However, during cellular activation and/or induction of cell death, PS is externalized on the outer surface via the activation of phospholipid scramblases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00543-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065380PMC

Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84.

Cell Commun Signal 2020 Feb 26;18(1):31. Epub 2020 Feb 26.

Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103, Leipzig, Germany.

Background: Medium-chain fatty acids and their 3-hydroxy derivatives are metabolites endogenously produced in humans, food-derived or originating from bacteria. They activate G protein-coupled receptors, including GPR84 and HCA, which regulate metabolism and immune functions. Although both receptors are coupled to G proteins, share at least one agonist and show overlapping tissue expression, GPR84 exerts pro-inflammatory effects whereas HCA is involved in anti-inflammatory responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-0516-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045412PMC
February 2020

FGFR3 signaling and function in triple negative breast cancer.

Cell Commun Signal 2020 Jan 27;18(1):13. Epub 2020 Jan 27.

Cancer Program, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.

Background: Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this study, mass spectrometry (MS)-based tyrosine phosphorylation profiling identified aberrant FGFR3 activation in a subset of TNBC cell lines. This kinase was therefore evaluated as a potential therapeutic target. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0486-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986078PMC
January 2020
3.378 Impact Factor

Ras isoforms: signaling specificities in CD40 pathway.

Cell Commun Signal 2020 Jan 6;18(1). Epub 2020 Jan 6.

National Centre for Cell Science, Ganeshkhind, Pune, 411007, India.

Background: Ras are small cellular GTPases which regulate diverse cellular processes. It has three isoforms: H-Ras, K-Ras, and N-Ras. Owing to the N-terminus (1-165 residues) sequence homology these isoforms were thought to be functionally redundant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0497-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945409PMC
January 2020
3.378 Impact Factor

RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans.

Cell Commun Signal 2020 Jan 3;18(1). Epub 2020 Jan 3.

Laboratory for Yeast Molecular and Cell Biology, Department of Food Science, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China.

Background: The calcium/calcineurin signaling pathway is mediated by the transcription factors NFAT (nuclear factor of activated T cells) in mammals and Crz1 (calcineurin-responsive zinc finger 1) in yeasts and other lower eukaryotes. A previous microarray analysis identified a putative Crz1-binding motif in promoters of its target genes in Candida albicans, but it has not been experimentally demonstrated.

Methods: An inactivation mutant for CaCRZ1 was generated through CRISPR/Cas9 approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0473-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942403PMC
January 2020
3.378 Impact Factor

Distinct functions of AKT isoforms in breast cancer: a comprehensive review.

Cell Commun Signal 2019 11 21;17(1):154. Epub 2019 Nov 21.

Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Background: AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0450-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873690PMC
November 2019

ATM controls DNA repair and mitochondria transfer between neighboring cells.

Authors:
Sha Jin Nils Cordes

Cell Commun Signal 2019 11 8;17(1):144. Epub 2019 Nov 8.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, D-01307, Dresden, Germany.

Intercellular communication is essential for multicellular tissue vitality and homeostasis. We show that healthy cells message protective signals through direct cell-cell connections to adjacent DNA-damaged cells in a microtubule-dependent manner. In DNA-damaged cells, mitochondria restoration is facilitated by fusion with undamaged mitochondria from healthy cells and their DNA damage repair is optimized in presence of healthy cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0472-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842230PMC
November 2019

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.

Cell Commun Signal 2019 10 24;17(1):135. Epub 2019 Oct 24.

Institute of Biology, Department of Systems Biology, Otto-von-Guericke University, Universitätsplatz 2, Gebäude 28/Pfälzer Platz, 39106, Magdeburg, Germany.

Background: Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0451-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814103PMC
October 2019

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma.

Cell Commun Signal 2019 10 16;17(1):127. Epub 2019 Oct 16.

Department of Pharmaceutical Sciences, College of Pharmacy, Qatar University, Doha, 2713, Qatar.

Background: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phloretin remain elusive.

Methods: Five HCC cells were tested in vitro for sensitivity to PH, Sorafenib (Sor) or both and the apoptosis, signal transduction and phosphatase activity were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0430-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794763PMC
October 2019
1 Read

Ventricular Zone Expressed PH Domain Containing 1 (VEPH1): an adaptor protein capable of modulating multiple signaling transduction pathways during normal and pathological development.

Cell Commun Signal 2019 09 9;17(1):116. Epub 2019 Sep 9.

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.

Ventricular Zone Expressed PH Domain-Containing 1 (VEPH1) is an 833-amino acid protein encoded by an evolutionarily conserved single-copy gene that emerged with pseudocoelomates. This gene has no paralog in any species identified to date and few studies have investigated the function of its encoded protein. Loss of expression of its ortholog, melted, in Drosophila results in a severe neural phenotype and impacts TOR, FoxO, and Hippo signaling. Read More

View Article

Download full-text PDF

Source
https://biosignaling.biomedcentral.com/articles/10.1186/s129
Publisher Site
http://dx.doi.org/10.1186/s12964-019-0433-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734325PMC
September 2019
3 Reads

CXCL1-LCN2 paracrine axis promotes progression of prostate cancer via the Src activation and epithelial-mesenchymal transition.

Cell Commun Signal 2019 09 10;17(1):118. Epub 2019 Sep 10.

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai, 200127, China.

Background: Mechanisms driving the progression of castration-resistant prostate cancer are believed to relate substantially to the tumor microenvironment. However, the cross-talks between tumor epithelial cell, stromal cells, and immune cells are yet to be fully elucidated. The present study aims to determine the role of chemokine and neutrophil derived cytokine paracrine axis in mediating the interaction between tumor cells, stromal myofibroblasts, and neutrophils in the tumor microenvironment of prostate cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0434-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734451PMC
September 2019
4 Reads

A novel population of extracellular vesicles smaller than exosomes promotes cell proliferation.

Cell Commun Signal 2019 08 15;17(1):95. Epub 2019 Aug 15.

Center for Bioanalysis, Korea Research Institute of Standards and Science, 267 Gajeong-ro, Yuseong-gu, Daejeon, Korea.

Background: Extracellular vesicles (EVs) play important roles in intercellular communication by delivering RNA, lipid, and proteins to neighboring or distant cells. Identification and classification of EVs secreted from diverse cell types are essential for understanding their signaling properties.

Methods: In this study, EVs from the culture media were isolated by ultracentrifugation and analyzed by electron microscopy (EM) and nanoparticle tracking analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0401-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694590PMC
August 2019
2 Reads

Palmitoylation is required for TNF-R1 signaling.

Cell Commun Signal 2019 08 5;17(1):90. Epub 2019 Aug 5.

Institute of Immunology, Christian-Albrechts-University of Kiel, Kiel, Germany.

Background: Binding of tumor necrosis factor (TNF) to TNF-receptor 1 (TNF-R1) can induce either cell survival or cell death. The selection between these diametrically opposed effects depends on the subcellular location of TNF-R1: plasma membrane retention leads to survival, while endocytosis leads to cell death. How the respective TNF-R1 associated signaling complexes are recruited to the distinct subcellular location is not known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0405-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683503PMC

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer.

Cell Commun Signal 2019 07 30;17(1):88. Epub 2019 Jul 30.

Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.

Background: Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC). We investigated whether WDR76 destabilizes RAS and acts as a tumor suppressor inhibiting CSC activation in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0403-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668196PMC
July 2019
2 Reads

miR-449a regulates insulin signalling by targeting the Notch ligand, Jag1 in skeletal muscle cells.

Cell Commun Signal 2019 07 25;17(1):84. Epub 2019 Jul 25.

CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110 007, India.

Background: miR-449a, an intronic miRNA, is highly down-regulated in the skeletal muscle during diabetes. Its levels are epigenetically regulated by altered acetylation/deacetylation on the promoter that it shares with its host gene, Cdc20b. However, the cellular role of this epigenetically regulated miRNA in the muscle during diabetes is not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0394-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659245PMC

EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer.

Cell Commun Signal 2019 07 25;17(1):83. Epub 2019 Jul 25.

Sydney Medical School, University of Sydney, Camperdown, Australia.

Background: Growth factors, such as EGF, activate the PI3K/Akt/mTORC1 signalling pathway, which regulates a distinct program of protein synthesis leading to cell growth. This pathway relies on mTORC1 sensing sufficient levels of intracellular amino acids, such as leucine, which are required for mTORC1 activation. However, it is currently unknown whether there is a direct link between these external growth signals and intracellular amino acid levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0400-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659227PMC
July 2019
1 Read
3.378 Impact Factor

SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways.

Cell Commun Signal 2019 07 25;17(1):82. Epub 2019 Jul 25.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.

Background: The SUMO-activating enzyme SAE1 is indispensable for protein SUMOylation. A dysregulation of SAE1 expression involves in progression of several human cancers. However, its biological roles of SAE1 in glioma are unclear by now. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0392-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659289PMC

MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling.

Cell Commun Signal 2019 07 18;17(1):78. Epub 2019 Jul 18.

Early Respiratory, Inflammation & Autoimmunity, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden.

Background: The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN) signalling. Dual specificity mitogen-activated protein kinase kinase (MEK) pathway contributes to epithelial defence, but its role in the regulation of IFN response in human primary airway epithelial cells (AECs) is not fully understood. Here, we studied the impact of a small-molecule inhibitor (MEKi) on the IFN response following challenge with two major respiratory viruses rhinovirus (RV2) and respiratory syncytial virus (RSVA2) and a TLR3 agonist, poly(I:C). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0378-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639958PMC
July 2019
1 Read

NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells.

Cell Commun Signal 2019 07 17;17(1):77. Epub 2019 Jul 17.

Shanghai Putuo Central School of Clinical Medicine, Anhui Medical University, Hefei, 230001, China.

Background: Lipogenesis is required for the optimal growth of many types of cancer cells, it is shown to control the biosynthesis of the lipid bilayer membrane during rapid proliferation and metastasis, provides cancer cells with signaling lipid molecules to support cancer development and make cancer cells more resistant to oxidative stress-induced cell death. Though multiple lipogenic enzymes have been identified to mediate this metabolic change, how the expression of these lipogenic enzymes are transcriptionally regulated remains unclear.

Methods: Gain- and loss-of-function experiments were conducted to assess the role of transcriptional repressor, nuclear receptor sub-family 6, group A, member 1 (NR6A1) in HepG2 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0389-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637573PMC
July 2019
3 Reads

TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression.

Cell Commun Signal 2019 07 15;17(1):75. Epub 2019 Jul 15.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen University Health Science Center, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Background: The major limitation of organ transplantation is the shortage of available organs. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection is a major hurdle for the successful survival of pig xenografts in primate recipients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0386-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631523PMC
July 2019
1 Read

ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms.

Cell Commun Signal 2019 07 10;17(1):74. Epub 2019 Jul 10.

Department of Pathology and Laboratory Medicine (JFL, LB, RCW, SJW, SLC), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.

Background: We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these receptors drive MPNST pathogenesis. Here, we test the hypothesis that altered erbB4 expression promotes MPNST pathogenesis by uniquely activating key cytoplasmic signaling cascades. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0388-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621970PMC
July 2019
3 Reads

Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by suppressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors.

Cell Commun Signal 2019 07 2;17(1):71. Epub 2019 Jul 2.

Institute of Immunology, Centre of Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58448, Witten, Germany.

Background: To date, several studies have confirmed that driving forces of the inflammatory tumour microenvironment trigger spontaneous cancer cell fusion. However, less is known about the underlying factors and mechanisms that facilitate inflammation-induced cell fusion of a cancer cell with a normal cell. Recently, we demonstrated that minocycline, a tetracycline antibiotic, successfully inhibited the TNF-α-induced fusion of MDA-MB-435 cancer cells with M13SV1 breast epithelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0384-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604204PMC
July 2019
1 Read

Intragenic regulation of SOCS3 isoforms.

Cell Commun Signal 2019 06 25;17(1):70. Epub 2019 Jun 25.

Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.

Background: Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short and long isoform. Here, we studied the inhibitory potential of the two SOCS3 isoforms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0379-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593527PMC
June 2019
1 Read

Cholecystokinin type B receptor-mediated inhibition of A-type K channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway.

Cell Commun Signal 2019 06 18;17(1):68. Epub 2019 Jun 18.

Department of Physiology and Neurobiology & Centre for Ion Channelopathy, Medical College of Soochow University, 199 Ren-Ai Road, Suzhou, 215123, People's Republic of China.

Background: Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.

Methods: Using patch clamp recording, western blot analysis, immunofluorescent labelling, enzyme-linked immunosorbent assays, adenovirus-mediated shRNA knockdown and animal behaviour tests, we studied the effects of CCK-8 on the sensory neuronal excitability and peripheral pain sensitivity mediated by A-type K channels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0385-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582535PMC
June 2019
3 Reads
3.378 Impact Factor

Novel interconnections of HOG signaling revealed by combined use of two proteomic software packages.

Cell Commun Signal 2019 06 17;17(1):66. Epub 2019 Jun 17.

Mass Spectrometry Facility, Max F. Perutz Laboratories, University of Vienna, Vienna BioCenter, Vienna, Austria.

Modern quantitative mass spectrometry (MS)-based proteomics enables researchers to unravel signaling networks by monitoring proteome-wide cellular responses to different stimuli. MS-based analysis of signaling systems usually requires an integration of multiple quantitative MS experiments, which remains challenging, given that the overlap between these datasets is not necessarily comprehensive. In a previous study we analyzed the impact of the yeast mitogen-activated protein kinase (MAPK) Hog1 on the hyperosmotic stress-affected phosphorylome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0381-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572760PMC
June 2019
7 Reads

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV.

Cell Commun Signal 2019 06 14;17(1):64. Epub 2019 Jun 14.

Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang Graduate School, Bucheon Hospital, Bucheon, South Korea.

Background: The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure. In this study, we assessed the role of mTORC1 and mTORC2 as well as the effect of rapamycin (sirolimus) on choroidal neovascularization (CNV) in a laser-induced mouse model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0380-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570852PMC
June 2019
13 Reads

Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways.

Cell Commun Signal 2019 06 11;17(1):62. Epub 2019 Jun 11.

Department of Respiratory Medicine, The First Hospital of Jilin University, Xinmin road 71, Changchun, Jilin, 130001, People's Republic of China.

Background: Oxidative stress and the resulting inflammation are essential pathological processes in acute lung injury (ALI). Nuclear factor erythroid 2-related factor 2 (Nrf2), a vital transcriptional factor, possesses antioxidative potential and has become a primary target to treat many diseases. Oridonin (Ori), isolated from the plant Rabdosia Rrubescens, is a natural substance that possesses antioxidative and anti-inflammatory effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0366-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558832PMC
June 2019
12 Reads

Interleukin-32θ inhibits tumor-promoting effects of macrophage-secreted CCL18 in breast cancer.

Cell Commun Signal 2019 05 24;17(1):53. Epub 2019 May 24.

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Jayang-dong, Gwangjin-gu, Seoul, 05029, Republic of Korea.

Background: Tumor-associated macrophages can promote breast cancer metastasis by secreting cytokines and growth factors. Interleukin (IL)-32θ, a newly identified IL-32 isoform, was previously shown to down-regulate various proinflammatory factors of macrophages. Here, we report the presence of IL-32θ in breast cancer tissues and evaluate its effects on macrophage-regulated breast cancer metastasis. Read More

View Article

Download full-text PDF

Source
https://biosignaling.biomedcentral.com/articles/10.1186/s129
Publisher Site
http://dx.doi.org/10.1186/s12964-019-0374-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534939PMC
May 2019
8 Reads

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling.

Cell Commun Signal 2019 05 17;17(1):46. Epub 2019 May 17.

Department of Systems Biology, Institute of Biology, Faculty of Natural Sciences, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.

Background: Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalling is initiated by binding of IL-6 to the IL-6 receptor α and subsequent binding to the signal transducing receptor subunit gp130. This active receptor complex initiates signalling through the Janus kinase/signal transducer and activator of transcription pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0356-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525395PMC
May 2019
1 Read

MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling.

Cell Commun Signal 2019 05 15;17(1):44. Epub 2019 May 15.

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Background: Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stage of prostate cancer (PCa). Dysregulation of PP1-meditaed AKT dephosphorylation might contribute to such an event but is not fully understood. As a newly identified tumor suppressor, MIIP exerts its role in various types of cancer but has not been investigated in PCa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0355-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521544PMC
May 2019
5 Reads

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling.

Cell Commun Signal 2019 05 6;17(1):42. Epub 2019 May 6.

Department of Cell Biology and Genetics, Core Facility of Development Biology, Chongqing Medical University, Chongqing, 400016, China.

Background: Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death. Autophagy is a well-defined process which governs overall cellular stress outcomes. Selective degradation of the ER mediated by autophagy occurs through a specific type of autophagy called ER-phagy, which ensures ER protein homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0353-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503447PMC
May 2019
5 Reads

Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids.

Cell Commun Signal 2019 05 2;17(1):40. Epub 2019 May 2.

School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK.

Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition to regulating genomic transcriptional activity via RA receptors (RARs) and retinoid X receptors (RXRs), non-genomic mechanisms of RA have been described, including the regulation of ERK1/2 kinase phosphorylation, but are poorly characterised. In this study, we test the hypothesis that genomic and non-genomic mechanisms of RA are regulated independently with respect to the involvement of ligand-dependent RA receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0352-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498645PMC
May 2019
1 Read

Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect.

Cell Commun Signal 2019 04 16;17(1):36. Epub 2019 Apr 16.

Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, 400038, China.

Background: The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and the molecular mechanisms of PC4 in breast cancer development and progression are still unknown.

Methods: We investigated PC4 expression in 114 cases of primary breast cancer and matched normal breast tissue specimens, and studied the impact of PC4 expression as well as the molecular mechanisms of this altered expression on breast cancer growth and metastasis both in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0348-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469038PMC
April 2019
9 Reads

Estrogen regulation of cardiac cAMP-L-type Ca channel pathway modulates sex differences in basal contraction and responses to βAR-mediated stress in left ventricular apical myocytes.

Cell Commun Signal 2019 04 15;17(1):34. Epub 2019 Apr 15.

Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Backgrounds/aim: Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Cachannel pathway in adult mice left ventricular (LV) apical myocytes at basal and stress state.

Methods: Isolated LV apical myocytes from male, female (Sham) and ovariectomised mice (OVX) were used to investigate contractility, Ca transients and L-type Ca channel (LTCC) function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0346-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466778PMC
April 2019
1 Read

Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells.

Cell Commun Signal 2019 04 11;17(1):31. Epub 2019 Apr 11.

Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, 475004, China.

Background: p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mechanism of PAK1 in esophageal squamous cell carcinoma (ESCC) remain unclear.

Methods: The expression of PAK1 was detected in both ESCC cell lines and clinical samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0343-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458688PMC
April 2019
3 Reads

DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway.

Cell Commun Signal 2019 03 22;17(1):28. Epub 2019 Mar 22.

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Science, Soochow University, 199 Ren Ai Road, Suzhou, 215123, China.

Background: Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is necessary for p53-mediated apoptosis. However, the signalling pathways regulated by DRAM1 are not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0341-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431019PMC
March 2019
3 Reads

Recombinant RGD-disintegrin DisBa-01 blocks integrin αβ and impairs VEGF signaling in endothelial cells.

Cell Commun Signal 2019 03 20;17(1):27. Epub 2019 Mar 20.

Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, Rod. Washington Luis, km 235 - SP-310 - São Carlos, São Paulo, CEP 13565-905, Brazil.

Background: Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αβ integrin and VEGF type 2 receptor (VEGFR2) in VEGF-induced angiogenesis. DisBa-01, a recombinant His-tag fusion, RGD-disintegrin from Bothrops alternatus snake venom, binds to αβ integrin with nanomolar affinity blocking cell adhesion to the extracellular matrix. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0339-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425665PMC
March 2019
4 Reads

NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer.

Cell Commun Signal 2019 03 18;17(1):24. Epub 2019 Mar 18.

Department of Biochemistry & Molecular Genetics, University of Virginia, P.O. Box 800733, Charlottesville, VA, 22908, USA.

Background: Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered energy utilization, identification of metabolic pathways that link EMT with cancer progression is needed. Work presented here indicates that mesenchymal NSCLC upregulates glutamine-fructose-6-phosphate transaminase 2 (GFPT2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0335-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421657PMC
March 2019
4 Reads

Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1.

Cell Commun Signal 2019 03 5;17(1):22. Epub 2019 Mar 5.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) signaling pathway that some growth factors promoted the migration and proliferation of tumor cells. The aim of this study is to explore the role of GPER-1 in AMF mediated regulatory mechanisms of EC recurrence and progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0336-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402158PMC
March 2019
16 Reads

Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B.

Cell Commun Signal 2019 03 4;17(1):21. Epub 2019 Mar 4.

Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, J1H 4N5, Canada.

Background: Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others, the modulation of cytokine expression patterns. The presence of multiple potential protein-tyrosine phosphatase (PTP) 1B substrates in PAF receptor signaling pathways brought us to investigate its involvement in PAF-induced cytokine expression in monocyte-derived dendritic cells (Mo-DCs) and to study the pathways involved in this modulation.

Methods: We used in-vitro-matured human dendritic cells and the HEK-293 cell line in our studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0334-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399872PMC
March 2019
3 Reads

A signalling cascade involving receptor-activated phospholipase A, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility.

Cell Commun Signal 2019 03 1;17(1):20. Epub 2019 Mar 1.

Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131, Naples, Italy.

Background: Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses through dephosphorylation of target molecules. Moreover, Shp1 regulates actin dynamics. One Shp1 target is Src, which controls many cellular functions including actin dynamics. Read More

View Article

Download full-text PDF

Source
https://biosignaling.biomedcentral.com/articles/10.1186/s129
Publisher Site
http://dx.doi.org/10.1186/s12964-019-0329-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396489PMC
March 2019
17 Reads

Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway.

Cell Commun Signal 2019 02 27;17(1):18. Epub 2019 Feb 27.

Department of Oral Medicine, Shanxi Medical University School and Hospital of Stomatology, NO. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.

Background: Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apoptosis by regulating microRNA-802 and p53-upregulated modulator of apoptosis (PUMA), but its roles in oral epithelial inflammatory responses in OLP are still unknown. Herein, we identify lipopolysaccharide (LPS) is able to enhance interferon gamma (IFNγ) and interleukin-1 beta (IL-1β) productions in human oral keratinocytes (HOKs) dependent on hypoxia-inducible factor-1α (HIF-1α). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0331-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391768PMC
February 2019
10 Reads

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells.

Cell Commun Signal 2019 02 20;17(1):14. Epub 2019 Feb 20.

Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park Bâtiment G, 1015, Lausanne, Switzerland.

Background: Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is associated with a pronounced increase in mitochondrial respiration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0326-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381748PMC
February 2019
2 Reads

Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells.

Cell Commun Signal 2019 02 19;17(1):13. Epub 2019 Feb 19.

Department of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 411A, Oklahoma City, OK, 73104, USA.

Background: Exosomes are small membrane-bound vesicles that contribute to tumor progression and metastasis by mediating cell-to-cell communication and modifying the tumor microenvironment at both local and distant sites. However, little is known about the predominant factors in exosomes that contribute to breast cancer (BC) progression. MTA1 is a transcriptional co-regulator that can act as both a co-activator and co-repressor to regulate pathways that contribute to cancer development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0325-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379974PMC
February 2019