76,694 results match your criteria Cell communication & adhesion[Journal]


NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans.

Nat Commun 2020 Jul 10;11(1):3467. Epub 2020 Jul 10.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.

Modulation of gap junction-mediated electrical synapses is a common form of neural plasticity. However, the behavioral consequence of the modulation and the underlying molecular cellular mechanisms are not understood. Here, using a C. Read More

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http://dx.doi.org/10.1038/s41467-020-17218-0DOI Listing

Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model.

J Biol Chem 2020 Jul 10. Epub 2020 Jul 10.

Tokai University, Japan.

Hepatitis B, a viral infection that affects the liver, is thought to affect over 257 million people worldwide, and long-term infection can lead to life-threatening issues such as cirrhosis or liver cancer. Chronic hepatitis B develops by the interaction between Hepatitis B virus (HBV) and host immune response. However, questions of how HBV-infected cells thwart immune system defenses remain unanswered. Read More

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http://dx.doi.org/10.1074/jbc.RA120.014317DOI Listing

The social nature of mitochondria: Implications for human health.

Neurosci Biobehav Rev 2020 Jul 8. Epub 2020 Jul 8.

Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

Sociality has profound evolutionary roots and is observed from unicellular organisms to multicellular animals. In line with the view that social principles apply across levels of biological complexity, a growing body of data highlights the remarkable social nature of mitochondria - life-sustaining endosymbiotic organelles with their own genome that populate the cell cytoplasm. Here, we draw from organizing principles of behavior in social organisms to reveal that similar to individuals among social networks, mitochondria communicate with each other and with the cell nucleus, exhibit group formation and interdependence, synchronize their behaviors, and functionally specialize to accomplish specific functions within the organism. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2020.04.017DOI Listing

Microfluidics Cell Loading-Dock System: Ordered Cellular Array for Dynamic Lymphocyte-Communication Study.

Adv Biosyst 2017 Oct 17;1(10):e1700085. Epub 2017 Aug 17.

Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA.

It remains a great challenge to establish a high-throughput platform that can explore the interactions among multiple lymphocytes (>2 cells) and retrieve the interested cells for downstream analysis. This study demonstrates a microfluidics cell loading-dock system (Cell-Dock) to enclose multiple cells in 1D, 2D, and 3D chambers with high throughput and efficiency and single-cell accuracy. The loading efficiencies of 95%, 85%, and 74% for one-, three-, and five-cell systems are achieved, respectively. Read More

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http://dx.doi.org/10.1002/adbi.201700085DOI Listing
October 2017

Myogenic cell expression of intercellular adhesion molecule-1 (ICAM-1) contributes to muscle regeneration after injury.

Am J Pathol 2020 Jul 7. Epub 2020 Jul 7.

School of Exercise and Rehabilitation Sciences, University of Toledo, Toledo, Ohio. Electronic address:

We investigated intercellular adhesion molecule-1 (ICAM-1), a membrane protein that mediates cell-to-cell adhesion and communication, as a mechanism through which the inflammatory response facilitates muscle regeneration after injury. Toxin-induced muscle injury to tibialis anterior muscles of wild type mice caused ICAM-1 to be expressed by a population of satellite cells/myoblasts and myofibers. Myogenic cell expression of ICAM-1 contributed to the restoration of muscle structure after injury, as regenerating myofibers were more abundant and myofiber size was larger for wild type compared to ICAM-1-/- mice during 28 d of recovery. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.06.009DOI Listing

Machine Learning Predicts Lymph Node Metastasis in Early-Stage Oral Tongue Squamous Cell Carcinoma.

J Oral Maxillofac Surg 2020 Jun 13. Epub 2020 Jun 13.

Professor, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; and Department Head, Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Purpose: Early-stage oral tongue squamous cell cancer (OTSCC) has a rate of metastasis to the cervical lymph nodes of 20 to 50%. This study aimed to build and validate 4 machine learning (ML) models to predict the occurrence of lymph node metastasis before and after surgery for early-stage (cT1N0 to cT2N0) OTSCC.

Materials And Methods: We designed a retrospective cross-sectional study and reviewed the clinical and pathologic records of patients with early-stage OTSCC. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.015DOI Listing

Monodirectional Tissue P Systems With Promoters.

IEEE Trans Cybern 2020 Jul 10;PP. Epub 2020 Jul 10.

Tissue P systems with promoters provide nondeterministic parallel bioinspired devices that evolve by the interchange of objects between regions, determined by the existence of some special objects called promoters. However, in cellular biology, the movement of molecules across a membrane is transported from high to low concentration. Inspired by this biological fact, in this article, an interesting type of tissue P systems, called monodirectional tissue P systems with promoters, where communication happens between two regions only in one direction, is considered. Read More

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http://dx.doi.org/10.1109/TCYB.2020.3003060DOI Listing

Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation.

Adv Biosyst 2019 Oct 3;3(10):e1900131. Epub 2019 Oct 3.

Department of Chemical Engineering, Technion - Israel Institute of Technology, Technion City, Haifa, 3200003, Israel.

Cell-cell cross talk is of great importance in cancer research due to its major role in proliferation, differentiation, migration, and influence on the apoptotic pathway. Different cell-cell communication mechanisms have come mainly from proteomic and genomic approaches. In this paper, a new route is reported for cross talk between cancer cells that occurs, even when they are far away from each other. Read More

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http://dx.doi.org/10.1002/adbi.201900131DOI Listing
October 2019

Mechanical Interaction between Cells Facilitates Molecular Transport.

Adv Biosyst 2019 Dec 4;3(12):e1900192. Epub 2019 Nov 4.

School of Mechanical Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.

In vivo, eukaryotic cells are embedded in a matrix environment, where they grow and develop. Generally, this extracellular matrix (ECM) is an anisotropic fibrous structure, through which macromolecules and biochemical signaling molecules at the nanometer scale diffuse. The ECM is continuously remodeled by cells, via mechanical interactions, which lead to a potential link between biomechanical and biochemical cell-cell interactions. Read More

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http://dx.doi.org/10.1002/adbi.201900192DOI Listing
December 2019

Ultrasoft Silicone Gel as a Biomimetic Passivation Layer in Inkjet-Printed 3D MEA Devices.

Adv Biosyst 2019 Sep 26;3(9):e1900130. Epub 2019 Jul 26.

Munich School of BioengineeringDepartment of Electrical and Computer Engineering, Technische Universität München, Boltzmannstraße 11, 85748, Garching, Germany.

Multielectrode arrays (MEAs) are versatile tools that are used for chronic recording and stimulation of neural cells and tissues. Driven by the recent progress in understanding of how neuronal growth and function respond to scaffold stiffness, development of MEAs with a soft cell-to-device interface has gained importance not only for in vivo but also for in vitro applications. However, the passivation layer, which constitutes the majority of the cell-device interface, is typically prepared with stiff materials. Read More

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http://dx.doi.org/10.1002/adbi.201900130DOI Listing
September 2019

Perivascular adipose tissue - an immune cell metropolis.

Exp Physiol 2020 Jul 9. Epub 2020 Jul 9.

Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.

New Findings: What is the topic of this review? The review discusses how eosinophils can contribute to the function of perivascular adipose tissue and explores the mechanisms involved. What advances does it highlight? Understanding the communication between the cell populations which constitute perivascular adipose tissue function is important for exploring therapeutic options in the treatment of obesity-related cardiovascular complications. This article highlights that eosinophils are able to directly contribute to healthy perivascular adipose tissue function. Read More

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http://dx.doi.org/10.1113/EP087872DOI Listing

Cell membrane-related toxic responses and disruption of intercellular communication in PCB mechanisms of toxicity: A review.

J Appl Toxicol 2020 Jul 10. Epub 2020 Jul 10.

Laboratory for Toxicology, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.

An understanding of polychlorinated biphenyl (PCB) congener-specific effects on cell membrane and intercellular communication is important within the studies of PCB absorption, organ-related PCB accumulation and exertion of toxic responses. Toxic potential of PCBs is linked to various deleterious effects on human health, including neurotoxicity, immunotoxicity, reproductive toxicity and genotoxicity and, recently in 2016 International Agency for Research on Cancer (IARC) has upgraded the classification of PCBs to Group 1 "Carcinogenic to humans." Proposed mechanisms of aforementioned PCBs adverse effects at cellular membrane level are: (i) downregulation of gap junction intercellular communication and/or connexins; (ii) compromised membrane integrity; and (iii) altered tight junction barrier function. Read More

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http://dx.doi.org/10.1002/jat.4019DOI Listing

Left Ventricular Noncompaction Syndrome: Genetic Insights and Therapeutic Perspectives.

Curr Cardiol Rep 2020 Jul 9;22(9):84. Epub 2020 Jul 9.

2nd Medical Department with Cardiology and Intensive Care Medicine, Krankenanstalt Rudolfstiftung, Vienna, Austria.

Purpose Of Review: To discuss the association of left ventricular hypertrabeculation/noncompaction (LVHT/LVNC/NCCM) with genetic disease and to outline the therapeutic options for non-symptomatic and symptomatic LVHT.

Recent Findings: A number of new mutated genes have been recently detected being associated with LVHT. There are indications that microtubules changing cell polarity, the transcription factor Nkx2-5, and NOTCH-1 signaling are involved in the pathogenesis of LVHT. Read More

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http://dx.doi.org/10.1007/s11886-020-01339-5DOI Listing

Heat exposure impairs porcine oocyte quality with suppressed actin expression in cumulus cells and disrupted F-actin formation in transzonal projections.

J Anim Sci Biotechnol 2020 6;11:71. Epub 2020 Jul 6.

MOE Joint International Research Laboratory of Animal Health & Food Safety, Nanjing Agricultural University, Nanjing, Jiangsu China.

Background: Transzonal projections (TZPs) constitute a structural basis for the communication between the oocyte and its surrounding cumulus cells (CCs), which play critical roles in promoting the oocyte maturation. Previously we found that heat stress (HS) causes loss of TZPs in porcine cumulus-oocyte complexes (COCs) with decreased density of filamentous actin (F-actin). However, the time-course responses of F-actin and its monomeric actins (β-actin and γ-actin) during the maturation of oocytes remain unclear. Read More

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http://dx.doi.org/10.1186/s40104-020-00477-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336674PMC

Contact area-dependent cell communication and the morphological invariance of ascidian embryogenesis.

Science 2020 Jul;369(6500)

CRBM, Université de Montpellier, CNRS, 34293 Montpellier, France.

Marine invertebrate ascidians display embryonic reproducibility: Their early embryonic cell lineages are considered invariant and are conserved between distantly related species, despite rapid genomic divergence. Here, we address the drivers of this reproducibility. We used light-sheet imaging and automated cell segmentation and tracking procedures to systematically quantify the behavior of individual cells every 2 minutes during embryogenesis. Read More

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http://dx.doi.org/10.1126/science.aar5663DOI Listing

Polyploidy: A Biological Force From Cells to Ecosystems.

Trends Cell Biol 2020 Jul 6. Epub 2020 Jul 6.

Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium; VIB Center for Plant Systems Biology, Ghent, Belgium; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa; College of Horticulture, Nanjing Agricultural University, Nanjing, China. Electronic address:

Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly affects genes and genomes, cells and tissues, organisms, and even entire ecosystems. Despite the wide-reaching importance of polyploidy, communication across disciplinary boundaries to identify common themes at different scales has been almost nonexistent. However, a critical need remains to understand commonalities that derive from shared polyploid cellular processes across organismal diversity, levels of biological organization, and fields of inquiry - from biodiversity and biocomplexity to medicine and agriculture. Read More

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http://dx.doi.org/10.1016/j.tcb.2020.06.006DOI Listing

Transcriptomic and Ultrastructural Signatures of K-Induced Aggregation in Zoospores.

Microorganisms 2020 Jul 7;8(7). Epub 2020 Jul 7.

Université Côte d'Azur, INRAE, CNRS, ISA, 06903 Sophia Antipolis, France.

Most pathogenic oomycetes of the genus spread in water films as flagellated zoospores. Zoospores perceive and produce signals attracting other zoospores, resulting in autoaggregation in vitro or biofilm formation on plant surface. The mechanisms underlying intercellular communication and consequent attraction, adhesion and aggregation are largely unknown. Read More

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http://dx.doi.org/10.3390/microorganisms8071012DOI Listing

Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.

Glia 2020 Jul 9. Epub 2020 Jul 9.

Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Glaucoma is a degenerative disease that causes irreversible loss of vision and is characterized by retinal ganglion cell (RGC) loss. Others and we have demonstrated that chronic neuroinflammation mediated by reactive microglial cells plays a role in glaucomatous pathology. Exosomes are extracellular vesicles released by most cells, including microglia, that mediate intercellular communication. Read More

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http://dx.doi.org/10.1002/glia.23880DOI Listing

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.

PLoS One 2020 9;15(7):e0228607. Epub 2020 Jul 9.

Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

Among the first steps in inflammation is the conversion of arachidonic acid (AA) stored in the cell membranes into leukotrienes. This occurs mainly in leukocytes and depends on the interaction of two proteins: 5-lipoxygenase (5LO), stored away from the nuclear membranes until use and 5-lipoxygenase activating protein (FLAP), a transmembrane, homotrimeric protein, constitutively present in nuclear membrane. We could earlier visualize the binding of 5LO to nanodiscs in the presence of Ca2+-ions by the use of transmission electron microscopy (TEM) on samples negatively stained by sodium phosphotungstate. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228607PLOS

Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa061. Epub 2020 May 27.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Background: Glioblastomas display a high level of intratumoral heterogeneity with regard to both genetic and histological features. Within single tumors, subclones have been shown to communicate with each other to affect overall tumor growth. The aim of this study was to broaden the understanding of interclonal communication in glioblastoma. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309246PMC

Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance between cells/tissues.

Theranostics 2020 12;10(16):7422-7435. Epub 2020 Jun 12.

Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, 300121, P.R. China.

Extracellular vesicles (EVs) including exosomes, microvesicles (MVs), and apoptotic bodies, are small membrane vesicular structures that are released during cell activation, senescence, or programmed cell death, including apoptosis, necroptosis, and pyroptosis. EVs serve as novel mediators for long-distance cell-to-cell communications and can transfer various bioactive molecules, such as encapsulated cytokines and genetic information from their parental cells to distant target cells. In the context of obesity, adipocyte-derived EVs are implicated in metabolic homeostasis serving as novel adipokines. Read More

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http://dx.doi.org/10.7150/thno.42167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330853PMC

Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.

Cell Death Dis 2020 Jul 8;11(7):513. Epub 2020 Jul 8.

Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu Province, 210009, China.

Exosomes are increasingly recognized as vehicles of intercellular communication. However, the role of exosome in maintaining cellular homeostasis under stress conditions remained unclear. Here we show that Rab27a expression was upregulated exclusively in tubular epithelial cells (TECs) during proteinuria nephropathy established by adriamycin (ADR) injection and 5/6 nephrectomy as well as in chronic kidney disease patients, leading to the increased secretion of exosomes carrying albumin. Read More

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http://dx.doi.org/10.1038/s41419-020-2709-4DOI Listing

LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.

Proc Natl Acad Sci U S A 2020 Jul 8. Epub 2020 Jul 8.

Neurobiology Section, Biological Sciences Division, University of California San Diego, La Jolla, CA 92093

Axon-axon interactions are essential for axon guidance during nervous system wiring. However, it is unknown whether and how the growth cones communicate with each other while sensing and responding to guidance cues. We found that the Parkinson's disease gene, leucine-rich repeat kinase 2 (, has an unexpected role in growth cone-growth cone communication. Read More

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http://dx.doi.org/10.1073/pnas.1921878117DOI Listing

mSphere of Influence: Communication Is Complicated-Just Ask a Bacterial Cell.

Authors:
Paola E Mera

mSphere 2020 Jul 8;5(4). Epub 2020 Jul 8.

Department of Microbiology, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA

Paola Mera works in the field of bacterial developmental biology. In this mSphere of Influence article, she reflects on how the paper "MipZ, a spatial regulator coordinating chromosome segregation with cell division in " by Martin Thanbichler and Lucy Shapiro (Cell 126:147-162, 2006, https://doi.org/10. Read More

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http://dx.doi.org/10.1128/mSphere.00580-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343980PMC

Cross talk between exosomes and pancreatic β-cells in diabetes.

Arch Physiol Biochem 2020 Jul 8:1-10. Epub 2020 Jul 8.

Diabetes Research Center, Medical School, Ningbo University, Ningbo, China.

Exosomes are a class of extracellular vesicles with a diameter of 50-100 nm secreted by various cells. They are generated through complex intracellular production mechanisms before being secreted to the extracellular environment. Due to their inclusion of proteins, lipids, and nucleic acids, exosomes play an important role in intercellular communication. Read More

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http://dx.doi.org/10.1080/13813455.2020.1760303DOI Listing

Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments.

Dev Cell 2020 Jun 30. Epub 2020 Jun 30.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Solid tumors reside in harsh tumor microenvironments (TMEs) together with various stromal cell types. During tumor progression and metastasis, both tumor and stromal cells undergo rapid metabolic adaptations. Tumor cells metabolically coordinate or compete with their "neighbors" to maintain biosynthetic and bioenergetic demands while escaping immunosurveillance or therapeutic interventions. Read More

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http://dx.doi.org/10.1016/j.devcel.2020.06.018DOI Listing

Immunoglobulin profile and B-cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions.

Immun Inflamm Dis 2020 Jul 8. Epub 2020 Jul 8.

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Introduction: B-cells are essential in the defense against Mycobacterium tuberculosis. Studies on isolated cells may not accurately reflect the responses that occur in vivo due to the presence of other cells. This study elucidated the influence of microenvironment complexity on B-cell polarization and function in the context of tuberculosis disease. Read More

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http://dx.doi.org/10.1002/iid3.328DOI Listing

The Biology and Therapeutic Potential of Mesenchymal Stem Cells derived Exosomes.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the potential to differentiate into several cell types. MSCs-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSCs are partially exerted by the secretion of soluble factors, in particular exosomes. Read More

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http://dx.doi.org/10.1111/cas.14563DOI Listing

A transcriptional toolbox for exploring peripheral neuro-immune interactions.

Pain 2020 Jun 24. Epub 2020 Jun 24.

Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Guy's Campus, London, SE1 1UL, United Kingdom.

Correct communication between immune cells and peripheral neurons is crucial for the protection of our bodies. Its breakdown is observed in many common, often painful conditions, including arthritis, neuropathies and inflammatory bowel or bladder disease. Here, we have characterised the immune response in a mouse model of neuropathic pain using flow cytometry and cell-type specific RNA sequencing (RNA-seq). Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001914DOI Listing

Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue.

J Neurosci Res 2020 Jul 7. Epub 2020 Jul 7.

Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany.

Microglial cells (resident macrophages) feature rapid activation in CNS disease and can acquire multiple phenotypes exerting neuroprotection or neurotoxicity. The functional impact of surveying ("resting") microglia on neural excitability and neurotransmission in physiology is widely unknown, however. We addressed this issue in male rat hippocampal slice cultures (in situ) by pharmacological microglial ablation within days and by characterizing neuronal gamma-band oscillations (30-70 Hz) that are highly sensitive to neuromodulators and disturbances in ion and energy regulation. Read More

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http://dx.doi.org/10.1002/jnr.24689DOI Listing

Mesenchymal stem cells derived-exosomes as a new therapeutic strategy for acute soft tissue injury.

Cell Biochem Funct 2020 Jul 7. Epub 2020 Jul 7.

Physical Education Department, Hohai University, Nanjing, Jiangsu, China.

The study aimed to investigate the role of exosomes derived from rat bone marrow mesenchymal stem cells (rBMSCs) in acute soft tissue injury and its related mechanisms. Exosomes were isolated from rBMSCs and characterized by Nanosight NS300 particle size analyser (NTA), transmission electron microscopy (TEM), and western blot. Twenty four rats were randomly divided into four groups (n = 6): control group, strike group, rBMSCs group, and rBMSCs-exo group. Read More

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http://dx.doi.org/10.1002/cbf.3570DOI Listing

Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis.

EJNMMI Res 2020 Jul 7;10(1):76. Epub 2020 Jul 7.

Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.

Background: We recently reported that enhanced [18F]-fluorodeoxyglucose (FDG) uptake in skeletal muscles predicts disease aggressiveness in patients with amyotrophic lateral sclerosis (ALS). The present experimental study aimed to assess whether this predictive potential reflects the link between FDG uptake and redox stress that has been previously reported in different tissues and disease models.

Methods: The study included 15 SOD1 mice (as experimental ALS model) and 15 wildtype mice (around 120 days old). Read More

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http://dx.doi.org/10.1186/s13550-020-00666-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340686PMC

The liver matrisome - looking beyond collagens.

JHEP Rep 2020 Aug 18;2(4):100115. Epub 2020 Apr 18.

Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA.

The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis. The classical definition of the ECM has more recently been extended to include non-fibrillar proteins that either interact or are structurally affiliated with the ECM, termed the 'matrisome.' In addition to providing the structure and architectural support for cells and tissue, the matrisome serves as a reservoir for growth factors and cytokines, as well as a signaling hub via which cells can communicate with their environment and vice-versa. Read More

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http://dx.doi.org/10.1016/j.jhepr.2020.100115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330160PMC

Osteoblast/fibroblast coculture derived bioactive ECM with unique matrisome profile facilitates bone regeneration.

Bioact Mater 2020 Dec 30;5(4):938-948. Epub 2020 Jun 30.

Zhejiang Key Laboratory of Pathophysiology, Medical School in Ningbo University, Ningbo, Zhejiang, PR China.

Extracellular matrix (ECM) with mimetic tissue niches was attractive to facilitate tissue regeneration via recruitment of endogenous cells and stimulation of self-healing process. However, how to engineer the complicate tissue specific ECM with unique matrisome was a challenge of ECM-based biomaterials in tissue engineering and regenerative medicine. Here, we introduced coculture system to engineer bone mimetic ECM niche guided by cell-cell communication. Read More

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http://dx.doi.org/10.1016/j.bioactmat.2020.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330453PMC
December 2020

Lysosomal recycling of amino acids affects ER quality control.

Sci Adv 2020 Jun 26;6(26):eaaz9805. Epub 2020 Jun 26.

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

Recent work has highlighted the fact that lysosomes are a critical signaling hub of metabolic processes, providing fundamental building blocks crucial for anabolic functions. How lysosomal functions affect other cellular compartments is not fully understood. Here, we find that lysosomal recycling of the amino acids lysine and arginine is essential for proper ER quality control through the UPR. Read More

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http://dx.doi.org/10.1126/sciadv.aaz9805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319768PMC

DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent Manner.

Front Cell Dev Biol 2020 19;8:449. Epub 2020 Jun 19.

Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

The disrupted in schizophrenia 1 (DISC1) protein is implicated in major mental illnesses including schizophrenia and bipolar disorder. A key feature of psychiatric disease is aberrant synaptic communication. Correct synaptic transmission is dependent on spatiotemporally regulated energy provision and calcium buffering. Read More

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http://dx.doi.org/10.3389/fcell.2020.00449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317294PMC

Fully-automatic deep learning-based analysis for determination of the invasiveness of breast cancer cells in an acoustic trap.

Biomed Opt Express 2020 Jun 11;11(6):2976-2995. Epub 2020 May 11.

Daegu Gyeongbuk Institute of Science and Technology,Department of Information and Communication Engineering, 333 Techno Jungang-daero, Hyeonpung-myun, Dalseong-gun, Daegu, 42988, South Korea.

A single-beam acoustic trapping technique has been shown to be very useful for determining the invasiveness of suspended breast cancer cells in an acoustic trap with a manual calcium analysis method. However, for the rapid translation of the technology into the clinic, the development of an efficient/accurate analytical method is needed. We, therefore, develop a fully-automatic deep learning-based calcium image analysis algorithm for determining the invasiveness of suspended breast cancer cells using a single-beam acoustic trapping system. Read More

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http://dx.doi.org/10.1364/BOE.390558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316006PMC

Ceramides in Adipose Tissue.

Front Endocrinol (Lausanne) 2020 19;11:407. Epub 2020 Jun 19.

Department of Nutrition and Integrative Physiology, The Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT, United States.

Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. Read More

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http://dx.doi.org/10.3389/fendo.2020.00407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316884PMC

Predicting response to immunotherapy in advanced non-small-cell lung cancer using tumor mutational burden radiomic biomarker.

J Immunother Cancer 2020 Jul;8(2)

Department of Thoracic Surgery, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China

Background: Tumor mutational burden (TMB) is a significant predictor of immune checkpoint inhibitors (ICIs) efficacy. This study investigated the correlation between deep learning radiomic biomarker and TMB, including its predictive value for ICIs treatment response in patients with advanced non-small-cell lung cancer (NSCLC).

Methods: CT images from 327 patients with TMB data (TMB median=6. Read More

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http://dx.doi.org/10.1136/jitc-2020-000550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342823PMC

Effect of Annealing Temperature on Spatial Atomic Layer Deposited Titanium Oxide and Its Application in Perovskite Solar Cells.

Nanomaterials (Basel) 2020 Jul 5;10(7). Epub 2020 Jul 5.

School of Opto-electronic and Communication Engineering, Xiamen University of Technology, Xiamen 361024, China.

In this study, spatial atomic layer deposition (sALD) is employed to prepare titanium dioxide (TiO) thin films by using titanium tetraisopropoxide and water as metal and water precursors, respectively. The post-annealing temperature is varied to investigate its effect on the properties of the TiO films. The experimental results show that the sALD TiO has a similar deposition rate per cycle to other ALD processes using oxygen plasma or ozone oxidant, implying that the growth is limited by titanium tetraisopropoxide steric hindrance. Read More

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http://dx.doi.org/10.3390/nano10071322DOI Listing

Intercellular Mitochondrial Transfer in the Tumor Microenvironment.

Cancers (Basel) 2020 Jul 4;12(7). Epub 2020 Jul 4.

Department of Clinical Studies, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic.

Cell-to-cell communication is a fundamental process in every multicellular organism. In addition to membrane-bound and released factors, the sharing of cytosolic components represents a new, poorly explored signaling route. An extraordinary example of this communication channel is the direct transport of mitochondria between cells. Read More

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http://dx.doi.org/10.3390/cancers12071787DOI Listing

Using Cytometry for Investigation of Purinergic Signaling in Tumor-Associated Macrophages.

Cytometry A 2020 Jul 7. Epub 2020 Jul 7.

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.

Tumor-associated macrophages are widely recognized for their importance in guiding pro-tumoral or antitumoral responses. Mediating inflammation or immunosuppression, these cells support many key events in cancer progression: cell growth, chemotaxis, invasiveness, angiogenesis and cell death. The communication between cells in the tumor microenvironment strongly relies on the secretion and recognition of several molecules, including damage-associated molecular patterns (DAMPs), such as adenosine triphosphate (ATP). Read More

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http://dx.doi.org/10.1002/cyto.a.24035DOI Listing

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells.

Elife 2020 Jul 7;9. Epub 2020 Jul 7.

Translational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.

Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. This approach may still be limited by the presence of immunosuppressive myeloid populations. Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. Read More

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http://dx.doi.org/10.7554/eLife.54854DOI Listing

Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes.

Cell Mol Neurobiol 2020 Jul 6. Epub 2020 Jul 6.

College of Pharmacy, Hunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, China.

Excitatory toxicity is still a hot topic in the study of ischemic stroke, and related research has focused mainly on neurons. Adenosine is an important neuromodulator that is known as a "biosignature" in the central nervous system (CNS). The protective effect of exogenous adenosine on neurons has been confirmed, but its mechanism remains elusive. Read More

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http://dx.doi.org/10.1007/s10571-020-00876-5DOI Listing

Therapeutic angiogenesis with exosomal microRNAs: an effectual approach for the treatment of myocardial ischemia.

Heart Fail Rev 2020 Jul 6. Epub 2020 Jul 6.

Halal Research center of IRI, FDA, Tehran, Iran.

Therapeutic angiogenesis presents a potential approach for treating ischemic heart diseases especially in patients who are not appropriate candidates for traditional approaches of revascularization. This approach acts through inducing the neovascularization or maturation of pre-existing collateral vessels into functional arteries to bypass the blocked arteries and restore perfusion to ischemic myocardium. Successful stimulation of local angiogenesis can be established by the cross talk between stem cells, endothelial cells, and cardiomyocytes, which is mainly mediated by paracrine communication accompanied by secreted exosomes. Read More

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http://dx.doi.org/10.1007/s10741-020-10001-9DOI Listing

Model lipid systems and their use to evaluate the phase state of biomembranes, their mechanical properties and the effect of non-conventional antibiotics: the case of daptomycin.

Eur Biophys J 2020 Jul 6;49(5):401-408. Epub 2020 Jul 6.

CNR-Nanoscience Institute-S3, Via Campi 213/A, 41125, Modena, Italy.

The lipid bilayer is the basis of the structure and function of the cell membrane. The study of the molecular phenomena that affect biological membranes has a great impact on the understanding of cellular physiology. To understand these phenomena, it has become increasingly necessary to develop simple synthetic models that allow the most basic details of such processes to be reproduced. Read More

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http://dx.doi.org/10.1007/s00249-020-01445-wDOI Listing

Chloroquine fumardiamides as novel quorum sensing inhibitors.

Bioorg Med Chem Lett 2020 Aug 9;30(16):127336. Epub 2020 Jun 9.

University of Zagreb, Faculty of Pharmacy and Biochemistry, HR 10000 Zagreb, Croatia. Electronic address:

Quorum sensing inhibitors (QSIs) that specifically interfere with bacterial cell-to-cell communication are considered as an alternative approach to conventional antibacterial therapy. In our study, a set of twenty-six fumardiamides with a quinoline head-group were evaluated as potential QSIs. Two strains of Gram-negative Chromobacterium violaceum (violacein-producing strain ATCC31532 and violacein-negative, mini-Tn5 mutant derivative CV026) were used as QS reporters for testing anti-QS and bactericidal activity of various quinoline fumardiamides. Read More

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http://dx.doi.org/10.1016/j.bmcl.2020.127336DOI Listing

Investigating the effects of noise exposure on self-report, behavioral and electrophysiological indices of hearing damage in musicians with normal audiometric thresholds.

Hear Res 2020 Jul 2:108021. Epub 2020 Jul 2.

Manchester Centre for Audiology and Deafness, University of Manchester, UK; Department of Linguistics, Macquarie University, Sydney, Australia.

Musicians are at risk of hearing loss due to prolonged noise exposure, but they may also be at risk of early sub-clinical hearing damage, such as cochlear synaptopathy. In the current study, we investigated the effects of noise exposure on electrophysiological, behavioral and self-report correlates of hearing damage in young adult (age range = 18-27 years) musicians and non-musicians with normal audiometric thresholds. Early-career musicians (n = 76) and non-musicians (n = 47) completed a test battery including the Noise Exposure Structured Interview, pure-tone audiometry (PTA; 0. Read More

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http://dx.doi.org/10.1016/j.heares.2020.108021DOI Listing

MicroRNA Milk Exosomes: From Cellular Regulator to Genomic Marker.

Animals (Basel) 2020 Jul 2;10(7). Epub 2020 Jul 2.

Department of Agriculture, Food, Environmental and Animal Science, University of Udine, 33100 Udine, Italy.

Recent advances in ruminants' milk-derived exosomes (EXO) have indicated a role of microRNAs (miRNAs) in cell-to-cell communication in dairy ruminants. The miRNAs EXO retain peculiar mechanisms of uptake from recipient cells, which enables the selective delivery of cargos, with a specific regulation of target genes. Although many studies have been published on the miRNAs contained in milk, less information is available on the role of miRNAs EXO, which are considered stable over time and resistant to digestion and milk processing. Read More

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http://dx.doi.org/10.3390/ani10071126DOI Listing