4,056 results match your criteria Cell biology international[Journal]


Knockdown of DNA binding protein A (dbpA) enhances the chemotherapy sensitivity of colorectal cancer via suppressing the Wnt/β-catenin/Chk1 pathway.

Cell Biol Int 2020 Jul 11. Epub 2020 Jul 11.

Department of hepatobiliary surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, P.R. China.

DNA-binding protein A (dbpA) is reported to be upregulated in many cancers and associated with tumor progress. The present study aimed to investigate the role of dbpA in 5-Fluorouracil (5-FU)-resistant and Oxaliplatin (L-OHP)-resistant colorectal cancer (CRC) cells. We found that 5-FU and L-OPH treatment promoted the expression of dbpA. Read More

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http://dx.doi.org/10.1002/cbin.11416DOI Listing

Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.

Cell Biol Int 2020 Jul 8. Epub 2020 Jul 8.

School of Life Sciences, BK21 Plus KNU Creative Bioresearch Group, Kyungpook National University, Daegu, Republic of Korea.

Reactive oxygen species (ROS) act as signaling molecules to regulate various cell functions. Numerous studies have demonstrated ROS to be essential for the differentiation of adipocytes. Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes in mammalian cells. Read More

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http://dx.doi.org/10.1002/cbin.11417DOI Listing

Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer.

Cell Biol Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Urology, Central Theater Command General Hospital of The Chinese People's Liberation Army, Wuhan, Hubei, 430070, P.R. China.

Prostate cancer (PCa) is one of the most common malignant tumors in the world. Thioredoxin interacting protein (TXNIP) is down-regulated in a variety of human tumors and plays an important role in tumor suppression. However, the expression level and biological functions of TXNIP in PCa have not been identified yet. Read More

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http://dx.doi.org/10.1002/cbin.11418DOI Listing
July 2020
1.933 Impact Factor

Are unusual ultrastructural features occurring in the pollen endomembrane system of Cyperaceae and other angiosperms?

Cell Biol Int 2020 Jul 1. Epub 2020 Jul 1.

Laboratory of Plant Anatomy LAVeg, Department of Botany, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Cyperaceae representatives present peculiar microsporogenesis and microgametogenesis, which raises the question of how regular the sedge pollen is. In order to answer this question, preanthesis pollen grains of Cyperaceae individuals were analyzed under different tools such as light and transmission electron microscopy, which included cytochemistry and immunogold procedures. The results showed that maturing pollen in Cyperaceae presents some unusual endomembrane behaviors. Read More

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http://dx.doi.org/10.1002/cbin.11415DOI Listing

NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6/JAK2/STAT3 pathway activation.

Cell Biol Int 2020 Jun 25. Epub 2020 Jun 25.

Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Nucleotide-binding domain, leucine-rich repeat family with a caspase activation and recruitment domain 3 (NLRC3) participates in both immunity and cancer. The aim of this study was to determine the role of NLRC3 in human hepatocellular carcinoma (HCC) and the underlying mechanisms. We collected human liver tissues from nonalcoholic steatohepatitis (NASH), HCC, and adjacent normal tissues to characterize the pattern of NLRC3 expression by real-time quantitative polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1002/cbin.11414DOI Listing

Antineoplastic drug-loaded polymer-modified magnetite nanoparticles: Comparative analysis of EPR-mediated drug delivery.

Cell Biol Int 2020 Jun 25. Epub 2020 Jun 25.

Department of Biology, Payame Noor University, Yazd, Iran.

This study aimed to design and evaluate EPR-mediated anticancer effect of polymer-modified and drug-loaded magnetite nanocomposites. The pre-formulated bare (10 nm), CS-SPIO (69 nm), HP-SPIO (42 nm) and AP-SPIO (17 nm) nano-composites were utilized to evaluate the EPR-mediated localized cancer targeting and retention of DOX and PTX in human ovarian cancer cell lines, A2780 and OVCAR-3 in vitro and in the tumor-baring Balb/c mice in vivo. Fluorescence microscopy showed that DOX- and PTX-loaded SPIO NPs caused long-term accumulation and cytoplasmic retention in A2780 and OVCAR-3 cells, as compared to free drugs in vitro. Read More

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http://dx.doi.org/10.1002/cbin.11413DOI Listing

Developmental stages of zebrafish (Danio rerio) embryos and toxicological studies using foldscope microscope.

Cell Biol Int 2020 Jun 25. Epub 2020 Jun 25.

Regeneration and Stem Cell Biology Lab, Centre for Molecular and Nanomedical Sciences, International Research Centre, Sathyabama Institute of Science and Technology, Chennai, Tamilnadu, India.

Zebrafish (Danio rerio), is a well-established vertebrate animal model widely used in developmental biology and toxicological research. In the present study, foldscope is used as an innovative tool to study the developmental stages and toxicological analysis of the zebrafish embryos. Briefly, the developmental stages, such as zygote, cleavage, blastula, gastrula, segmentation, and pharyngula formation are observed and documented using simple foldscope. Read More

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http://dx.doi.org/10.1002/cbin.11412DOI Listing

Orphan nuclear receptor RORγ confers doxorubicin resistance in prostate cancer.

Cell Biol Int 2020 Jun 25. Epub 2020 Jun 25.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.

Prostate cancer (PCa) is a malignant tumor with an extremely high prevalence. Doxorubicin is the first-line clinical treatment for castration-resistant PCa. Clinically, relapse is almost inevitable due to the cancer cells' increasing resistance to doxorubicin. Read More

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http://dx.doi.org/10.1002/cbin.11411DOI Listing

Prostate cancer cells modulate the differentiation of THP-1 cells in response to etoposide and TLR agonists treatments.

Cell Biol Int 2020 Jun 25. Epub 2020 Jun 25.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The aim of this study was to determine the polarization of macrophages in the tumor microenvironment, as well as the effect of soluble factors secreted from these polarized macrophages on etoposide-induced cancer cell apoptosis. We investigated the effect of soluble factors secreted from the supernatant of PC3 cells treated with TLR4 and TLR8 agonists, and etoposide on macrophage polarization at the protein level through flow cytometry and enzyme-linked immunosorbent assay. We further explored the cell cycle distribution and phagocytic activity of THP-1 cells by flow cytometry. Read More

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http://dx.doi.org/10.1002/cbin.11410DOI Listing

Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation.

Cell Biol Int 2020 Jun 18. Epub 2020 Jun 18.

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

The clinical application of stem cells offers great promise as a potential avenue for therapeutic use in neurodegenerative diseases. However, cell loss after transplantation remains a major challenge which currently plagues the field. Based on our previous findings that fibroblast growth factor 21 (FGF-21) protected neurons from glutamate excitotoxicity and that upregulation of FGF-21 in a rat model of ischemic stroke was associated with neuroprotection, we proposed that overexpression of FGF-21 protects bone marrow-derived mesenchymal stem cells (MSCs) from apoptosis. Read More

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http://dx.doi.org/10.1002/cbin.11409DOI Listing

Delivery of BR2-SOX17 fusion protein can inhibit cell survival, proliferation, and invasion in gastric cancer cells through regulating Klotho gene expression.

Cell Biol Int 2020 Jun 16. Epub 2020 Jun 16.

Department of Cancer, The First Affiliated Hospital of Changsha Medical School, Changsha, Hunan, China.

The prognosis of advanced gastric cancer is poor and understanding the biology and subsequent development of new targeting therapy is still an urgent need. This study was conducted to explore the effect of BR2 (a 17-amino acid peptide)-SOX17 (human sex determining region Y (SRY)-related high-mobility group (HMG) box protein family member 17) fusion protein on Klotho gene expression in gastric cancer cells. The regulatory effects of SOX17 on Klotho gene in gastric cancer cells were tested using dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay. Read More

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http://dx.doi.org/10.1002/cbin.11407DOI Listing
June 2020
1.933 Impact Factor

ABCC9, NKAPL, and TMEM132C are potential diagnostic and prognostic markers in triple-negative breast cancer.

Cell Biol Int 2020 Jun 16. Epub 2020 Jun 16.

Thyroid and Breast Department III, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. The aim of this study is to identify the diagnostic and poor prognostic signatures in TNBC by exploring the aberrant DNA methylation and gene expression. Differential expression and methylation analysis of the TNBC and paracancer samples from The Cancer Genome Atlas were performed. Read More

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http://dx.doi.org/10.1002/cbin.11406DOI Listing

miR-582-5p serves as an antioncogenic biomarker in intermediate risk AML with normal cytogenetics and could inhibit proliferation and induce apoptosis of leukemia cells.

Cell Biol Int 2020 Jun 16. Epub 2020 Jun 16.

Department of Hematology, Second Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Numerous studies confirmed that aberrant microRNA (miRNA) expression contributes to cancer development and progression. We carried out this study to explore the expression profile of miRNAs in intermediate risk acute myeloid leukemia (AML) and locate certain miRNAs as biomarkers. We profiled differentially expressed miRNAs by performing miRNA sequencing analysis in the patients' samples. Read More

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http://dx.doi.org/10.1002/cbin.11408DOI Listing

LncRNA-XIST promotes the oxidative stress-induced migration, invasion, and epithelial-to-mesenchymal transition of osteosarcoma cancer cells through miR-153-SNAI1 axis.

Cell Biol Int 2020 Jun 9. Epub 2020 Jun 9.

Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long-distance organ metastasis. Thus, investigating the specifically targeted therapeutic agents against metastatic osteosarcoma depends on understanding the molecular mechanisms. The long noncoding RNAs (lncRNA) XIST (X-inactive specific transcript) has been reported to have oncogenic roles in various malignant tumors including OS. Read More

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http://dx.doi.org/10.1002/cbin.11405DOI Listing

Mechanisms of programmed cell death in the midgut and salivary glands from Bradysia hygida (Diptera: Sciaridae) during pupal-adult metamorphosis.

Cell Biol Int 2020 Jun 4. Epub 2020 Jun 4.

Departament of Structural Biology, Molecular and Genetics, University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.

Programmed cell death is involved with the degeneration/remodeling of larval tissues and organs during holometabolous development. The midgut is a model to study the types of programmed cell death associated with metamorphosis because its structure while degenerating is a substrate for the formation of the adult organ. Another model is the salivary glands from dipteran because their elimination involves different cell death modes. Read More

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http://dx.doi.org/10.1002/cbin.11404DOI Listing

Lymphopenia in COVID-19: Therapeutic opportunities.

Cell Biol Int 2020 May 27. Epub 2020 May 27.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of SARS-CoV-2, natural killer cells and T cells become exhausted and decreasing their count leads to lymphopenia. Read More

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http://dx.doi.org/10.1002/cbin.11403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283672PMC
May 2020
1.933 Impact Factor

May we target double-membrane vesicles and oxysterol-binding protein to combat SARS-CoV-2 infection?

Cell Biol Int 2020 May 25. Epub 2020 May 25.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1002/cbin.11400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280599PMC
May 2020
1.933 Impact Factor

Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy.

Authors:
Rui Kong

Cell Biol Int 2020 May 25. Epub 2020 May 25.

Department of Oncology, The Third Affiliated Hospital of ChongQing Medical University, Chongqing, China.

Non-small-cell lung carcinoma (NSCLC) continues to top the list of cancer mortalities worldwide. The role of circular RNAs (circRNAs) in tumorigenesis has been increasingly appreciated, although it is relatively unexplored in NSCLC. Herein, we reported the role of hsa_circ_0085131 in NSCLC. Read More

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http://dx.doi.org/10.1002/cbin.11401DOI Listing

A review of the chemopreventative and chemotherapeutic properties of the phytochemicals berberine, resveratrol and curcumin, and their influence on cell death via the pathways of apoptosis and autophagy.

Authors:
Mark Sean D'Arcy

Cell Biol Int 2020 May 25. Epub 2020 May 25.

Biology Division, Hertfordshire International College, College Lane Campus, Hatfield, UK.

Phytochemicals are a diverse group of compounds found in a variety of fruits, vegetables and herbs, and have been reported to possess a number of health benefits. Marketed as supplements by health food retailers, this group of naturally occurring compounds have been investigated for a number of years to determine if they possess any chemopreventative and/or chemotherapeutic benefits. In this comprehensive review, the phytochemicals resveratrol, berberine and curcumin will be discussed, with particular focus being given to their proposed anticancer applications. Read More

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http://dx.doi.org/10.1002/cbin.11402DOI Listing

Reduced expression of CYLD promotes cell survival and inflammation in gefitinib-treated NSCLC PC-9 cells: Targeting CYLD may be beneficial for acquired resistance to gefitinib therapy.

Cell Biol Int 2020 May 22. Epub 2020 May 22.

Central Laboratory of Binhu Hospital, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

The application of tyrosine kinase inhibitors (TKIs) to the epidermal growth factor receptor (EGFR) has been proven to be highly effective for non-small-cell lung cancer (NSCLC). However, patients often evolve into acquired resistance. The secondary mutations in EGFR account for nearly half of the acquired resistance. Read More

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http://dx.doi.org/10.1002/cbin.11397DOI Listing

Tumor-suppressor Fbxw7 targets SIK2 for degradation to interfere with TORC2-AKT signaling in pancreatic cancer.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The tumor suppressor F-box/WD repeat-containing protein 7 (Fbxw7) is a substrate-recognition subunit of a ubiquitin ligase complex. We have previously proposed that Fbxw7 inhibited pancreatic cancer cell proliferation and invasion by targeting β-catenin. To identify other targets of Fbxw7 involved in pancreatic carcinogenesis, we screened the human protein database for Fbxw7 target candidates using the conserved Fbxw7-recognizing sequences. Read More

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http://dx.doi.org/10.1002/cbin.11396DOI Listing

G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Interdisciplinary Science and Engineering in Health Systems, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan.

Granulocyte colony-stimulating factor (G-CSF) stimulation of myeloid cells induced tyrosine-phosphorylation of cellular proteins. One of the tyrosine-phosphorylated proteins was found to be a scaffold protein, Grb2-associated binding protein 2 (Gab2). Another member of Gab family protein, Gab3, was exogenously overexpressed in neutrophil progenitor cells to make the Gab3 protein to compete with the endogenous Gab2 for the G-CSF-dependent signaling. Read More

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http://dx.doi.org/10.1002/cbin.11398DOI Listing

Fibronectin promotes tumor cells growth and drugs resistance through a CDC42-YAP-dependent signaling pathway in colorectal cancer.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Colorectal Surgery, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Fibronectin (FN) is a high-molecular-weight glycoprotein of the extracellular matrix (ECM) that binds to membrane-spanning receptor proteins or other elements in ECM. The expression of FN could be involved in the cancer cells proliferation or migration, and the molecular mechanisms responsible for FN induced protumor signals begin to be elucidated. Here, we report that the elevated expression of FN was observed in those chemoresistant tumor tissues from patients with colorectal cancer. Read More

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http://dx.doi.org/10.1002/cbin.11390DOI Listing

Epidermal growth factor and three-dimensional scaffolds provide conducive environment for differentiation of mouse embryonic stem cells into oocyte-like cells.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Stem Cell Research Laboratory, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Three-dimensional (3D) culture provides a biomimicry of the naive microenvironment that can support cell proliferation, differentiation, and regeneration. Some growth factors, such as epidermal growth factor (EGF), facilitate normal meiosis during oocyte maturation in vivo. In this study, a scaffold-based 3D coculture system using purified alginate was applied to induce oocyte differentiation from mouse embryonic stem cells (mESCs). Read More

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http://dx.doi.org/10.1002/cbin.11391DOI Listing

Anticarcinogenic effects of halofuginone on lung-derived cancer cells.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Molecular Biology & Genetics, Faculty of Science, Gebze Technical University, Gebze, Kocaeli, Turkey.

Malignant mesothelioma is a rare but aggressive form of malignancy, which is difficult to diagnose and is resistant to current chemotherapeutic treatment options. Molecular techniques have been used to investigate the mechanisms of action and the beneficial therapeutic effects of halofuginone (HF) in several cancers but not malignant mesotheliomas. In this study, the antiproliferative and apoptotic effects of HF were investigated through its ability to deregulate EGFR downstream signalling cascade proteins in the pathologically aggressive malignant mesothelioma and non-small-cell lung cancer cells. Read More

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http://dx.doi.org/10.1002/cbin.11399DOI Listing

BIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Adjuvant chemotherapy in combination with surgery is expected to be a curative strategy for gastric cancer. However, drug resistance remains an obstacle in effective chemotherapy. Therefore, understanding the potential mechanisms of chemotherapy induced gastric cancer cell death is of great importance. Read More

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http://dx.doi.org/10.1002/cbin.11395DOI Listing

Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Endocrinology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Diabetic nephropathy (DN) is a severe diabetic microvascular complication with high mortality. Long noncoding RNAs (lncRNAs) are characterized as important regulators of various biological processes by emerging researches, whereas the molecular mechanisms by which lncRNAs participate in DN progression need to be further clarified. Herein, we conducted a study on the regulatory role in DN of an lncRNA named antisense of Igf2r non-protein-coding RNA (Airn). Read More

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http://dx.doi.org/10.1002/cbin.11392DOI Listing

Folium Sennae and emodin reverse airway smooth muscle contraction.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area and Hubei Medical Biology International Science and Technology Cooperation Base, Institute for Medical Biology, College of Life Sciences, South-Central University for Nationalities, Wuhan, China.

The objective of this project was to find a bronchodilatory compound from herbs and clarify the mechanism. We found that the ethanol extract of Folium Sennae (EEFS) can relax airway smooth muscle (ASM). EEFS inhibited ASM contraction, induced by acetylcholine, in mouse tracheal rings and lung slices. Read More

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http://dx.doi.org/10.1002/cbin.11393DOI Listing
May 2020
1.933 Impact Factor

TNF-α regulates the early development of avascular necrosis of the femoral head by mediating osteoblast autophagy and apoptosis via the p38 MAPK/NF-κB signaling pathway.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Previous studies have shown that the tumor necrosis factor-α (TNF-α) levels in serum and bone tissues formed in avascular necrosis of femoral head (ANFH) patients were higher than those of normal individuals, indicating TNF-α might play a role in the pathogenesis of ANFH. However, the underlying mechanisms remain unclear. Hematoxylin and eosin staining was performed to show the pathological changes of ANFH bone tissues. Read More

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http://dx.doi.org/10.1002/cbin.11394DOI Listing

Sulforaphane ameliorates serum starvation-induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells.

Cell Biol Int 2020 May 13. Epub 2020 May 13.

Department of Biological Science, Ajou University, Suwon, Korea.

Oxidative stress, an imbalance of redox homeostasis, contributes to the pathogenesis and progress of muscle atrophy. However, it is debated whether oxidative stress is a cause or consequence of muscle atrophy. In this study, we investigated the relationship between menadione-induced oxidative stress and serum starvation-induced muscle atrophy in C2C12 myotubes. Read More

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http://dx.doi.org/10.1002/cbin.11377DOI Listing

TMEM98 mRNA promotes proliferation and invasion of gastric cells by directly interacting with NF90 protein.

Cell Biol Int 2020 May 7. Epub 2020 May 7.

Department of Breast Oncology, Affiliated People's Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Transmembrane protein 98 (TMEM98) is a recently discovered gene, the inhibition of which has preliminarily been demonstrated to inhibit progression of several solid cancers in vitro. However, its involvement in tumorigenesis of gastric cancer (GC) has not been reported. Here, we aimed to explore the expression of TMEM98 in GC tissues and cell lines and to determine the role of TMEM98 in GC cell proliferation and invasion. Read More

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http://dx.doi.org/10.1002/cbin.11375DOI Listing

Single-cell sequencing of miRNAs: A modified technology.

Cell Biol Int 2020 May 7. Epub 2020 May 7.

College of Pharmacy and Health Care, Tajen University, Yanpu, Pingtung, Taiwan.

The recent development of next-generation sequencing technologies has offered valuable insights into individual cells. This technology is centered on the characterization of single cells for epigenomics, genomics, and transcriptomics. Ever since the first report appeared in 2009, the single-cell RNA-sequencing saga started to explore deeper into the mechanics intrigued within a single cell. Read More

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http://dx.doi.org/10.1002/cbin.11376DOI Listing
May 2020
1.933 Impact Factor

The long noncoding RNA NR_045363 involves cardiomyocyte apoptosis and cardiac repair via p53 signal pathway.

Cell Biol Int 2020 May 6. Epub 2020 May 6.

Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China.

Long noncoding RNAs (lncRNAs) can participate in various biological behaviors, including regulating cell differentiation, proliferation, and apoptosis. The investigators have previously confirmed that highly conserved lncRNA NR_045363 controls cardiomyocyte (CM) proliferation and cardiac repair. The present study investigates the effects of NR_045363 on CM apoptosis. Read More

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http://dx.doi.org/10.1002/cbin.11374DOI Listing

FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signaling pathways.

Cell Biol Int 2020 May 6. Epub 2020 May 6.

Department of Neurology, Yueyang Second People's Hospital, Yueyang, Hunan, China.

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is caused by the interaction of genetic and environmental factors. Current studies have shown that Fc-receptor like-3 (FCRL3) is closely related to MS, but the specific role of FCRL3 in MS has not yet been clarified. This study further found that FCRL3 and interleukin 10 (IL-10) expression was downregulated in MS patients, but the expression of these proteins was higher in the remission phase than that in the acute phase. Read More

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http://dx.doi.org/10.1002/cbin.11373DOI Listing

miR-16 exhibits protective function in LPS-treated cardiomyocytes by targeting DOCK2 to repress cell apoptosis and exert anti-inflammatory effect.

Cell Biol Int 2020 May 5. Epub 2020 May 5.

Intervention Room, Department of Cardiology, Tengzhou Central People's Hospital Affiliated to Jining Medical College, Tengzhou, Shandong, China.

This study aims to investigate the effects of microRNA (miR)-16/dedicator of cytokinesis 2 (DOCK2) on myocarditis. The differences in the expression of genes in acute myocarditis were filtered out across Gene Expression Omnibus (GEO) database. Myocarditis cell model was established by lipopolysaccharide (LPS) stimulation in cardiomyocytes. Read More

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http://dx.doi.org/10.1002/cbin.11371DOI Listing

Overexpression of long noncoding RNA HOXA-AS2 predicts an adverse prognosis and promotes tumorigenesis via SOX4/PI3K/AKT pathway in acute myeloid leukemia.

Cell Biol Int 2020 May 5. Epub 2020 May 5.

Department of Hematology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes and carcinogenesis. Homeobox A cluster antisense RNA 2 (HOXA-AS2) is a 1,048-basepairs lncRNA located between human HOXA3 and HOXA4 genes, whose overactivation was previously found to promote the proliferation and invasion of solid tumors. However, its clinical and biological roles in acute myeloid leukemia (AML) remain unclear. Read More

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http://dx.doi.org/10.1002/cbin.11370DOI Listing
May 2020
1.933 Impact Factor

Inhibition of miR-103a-3p suppresses lipopolysaccharide-induced sepsis and liver injury by regulating FBXW7 expression.

Cell Biol Int 2020 May 5. Epub 2020 May 5.

Department of Anesthesiology, Tenth People's Hospital, Tongji University, NO. 301, Yan-Chang-Zhong Road, Shanghai, China.

Inflammation, apoptosis, and oxidative stress are involved in septic liver dysfunction. Herein, the role of miR-103a-3p/FBXW7 axis in lipopolysaccharides (LPS)-induced septic liver injury was investigated in mice. Hematoxylin-eosin staining was used to evaluate LPS-induced liver injury. Read More

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http://dx.doi.org/10.1002/cbin.11372DOI Listing

Neuroprotective potential of choline alfoscerate against β-amyloid injury: Involvement of neurotrophic signals.

Cell Biol Int 2020 Apr 28. Epub 2020 Apr 28.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Alzheimer's disease represents the most prevalent neurodegeneration worldwide, clinically characterized by cognitive and memory impairment. New therapeutic approaches are extremely important to counteract this disorder. This research is focused on the potential use of choline alfoscerate in preventing neuronal death using in vitro models of Alzheimer's disease, representing the early stage of the disease, treated before or after the insult with glycerylphosphorylcholine. Read More

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http://dx.doi.org/10.1002/cbin.11369DOI Listing

APPL1 as an important regulator of insulin and adiponectin-signaling pathways in the PCOS: A narrative review.

Cell Biol Int 2020 Apr 27. Epub 2020 Apr 27.

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Adaptor protein containing a PH domain, PTB domain and leucine zipper motif 1 (APPL1) plays a central role as the main contributing factor in the adiponectin and insulin signaling. This review aims to discuss previous and recent findings concerning the role of APPL1 in the polycystic ovary syndrome (PCOS) patients with conclusions regarding more efficient therapeutic approaches. A literature review was performed in PubMed, Web of Science, ScienceDirect, Scopus, and Google Scholar from August 1999 to May 2020. Read More

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http://dx.doi.org/10.1002/cbin.11367DOI Listing

In vitro and in vivo studies of cancer cell behavior under nutrient deprivation.

Cell Biol Int 2020 Apr 27. Epub 2020 Apr 27.

Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Cancer cells are confronted with nutrient deprivation because of high proliferation rate, especially at the early stage of their development. There is a frequent assumption that nutrient deprivation decreases the basal activity of cancer cells. Contrarily, there are recent evidence suggesting that cancer cells are able to modulate signaling pathways to adapt with new condition and continue their survival. Read More

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http://dx.doi.org/10.1002/cbin.11368DOI Listing

PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.

Cell Biol Int 2020 Apr 27. Epub 2020 Apr 27.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu, China.

PRCC-TFE3 translocation renal cell carcinomas (tRCC) is a common subtype of TFE3 tRCCs in which TFE3 fusions are indicated as oncogenes to promote tumor development. PRCC-TFE3 fusions are often accumulated in the nucleus and related to poorer outcomes and higher stages (III/IV). In this study, we found that PRCC-TFE3 could positively regulate expression of both dynamin-related protein 1 (Drp1) and fission protein 1, and alter distribution of mitochondria, which could promote cell migration and invasion independent of matrix metalloproteinase-2 (MMP-2) and MMP-9. Read More

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http://dx.doi.org/10.1002/cbin.11366DOI Listing
April 2020
1.933 Impact Factor

A comparative study of hBM-MSCs' differentiation toward osteogenic lineage in the presence of progesterone and estrogen hormones separately and concurrently in vitro.

Cell Biol Int 2020 Apr 27. Epub 2020 Apr 27.

Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran.

Promising cell sources for tissue engineering comprise bone marrow derived-mesenchymal stem cells (BM-MSCs) that have multiple differentiation potentials. Also, sex hormones act as important elements in bone development and maintenance, and the roles of two female sex steroid hormones known as estrogen (17-β estradiol) and progesterone in osteogenic differentiation of human BM-MSCs (hBM-MSCs) are studied. For this purpose, hBM-MSCs were treated with a 1 × 10  M concentration of 17-β estradiol and progesterone separately and simultaneously while the optimum concentrations were obtained by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Read More

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http://dx.doi.org/10.1002/cbin.11364DOI Listing

Long noncoding RNA SNHG12 promotes vascular smooth muscle cell proliferation and migration via regulating miR-199a-5p/HIF-1α.

Cell Biol Int 2020 Apr 27. Epub 2020 Apr 27.

Department of Vascular Surgery, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China.

The dysregulation of proliferation and migration of vascular smooth muscle cells (VSMCs) contributes to atherosclerosis (AS) and accumulating reports indicate the crucial role of long noncoding RNA in AS. However, the role of small nucleolar RNA host gene 12 (SNHG12) in regulating the phenotypes of VSMCs and AS remains largely unknown. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was used to detect the expression levels of SNHG12 and miR-199a-5p in an in vivo AS model and VSMCs treated by oxidized low-density lipoprotein (ox-LDL). Read More

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http://dx.doi.org/10.1002/cbin.11365DOI Listing

Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway.

Cell Biol Int 2020 Apr 13. Epub 2020 Apr 13.

Department of Pathophysiology, Harbin Medical University, Harbin, China.

Myocardial fibrosis is one of the main pathological manifestations of diabetic cardiomyopathy (DCM). Spermine (SPM), a product of polyamine metabolism, plays an important role in many cardiac diseases including hypertrophy, ischemia, and infarction, but its role in diabetic myocardial fibrosis has not been clarified. This study aimed to investigate the role of polyamine metabolism, specifically SPM, in diabetic myocardial fibrosis and to explore the related mechanisms. Read More

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http://dx.doi.org/10.1002/cbin.11360DOI Listing

Critical roles of tyrosyl-DNA phosphodiesterases in cell tolerance to carnosol-induced DNA damage.

Cell Biol Int 2020 Apr 17. Epub 2020 Apr 17.

Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.

Carnosol is a natural compound with pharmacological action due to its anti-cancer properties. However, the precise mechanism for its anti-carcinogenic effect remains elusive. In this study, we used lymphoblastoid TK6 cell lines to identify the DNA damage and repair mechanisms of carnosol. Read More

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http://dx.doi.org/10.1002/cbin.11357DOI Listing

Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.

Cell Biol Int 2020 Apr 16. Epub 2020 Apr 16.

Department of Nephrology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Sonic hedgehog (Shh) signaling regulating epithelial-mesenchymal transition (EMT) in cultured rat peritoneal mesothelial cells (PMCs) remains an under-investigated topic. The current study aimed to elucidate the role of Shh signaling in the regulation of EMT in PMCs to attenuate peritoneal injury, with the view of enhancing the efficacy of peritoneal dialysis (PD). PMCs were initially extracted from male Wistar rats using pancreatic enzyme digestion. Read More

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http://dx.doi.org/10.1002/cbin.11363DOI Listing

USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/β-catenin pathway via Axin1 deubiquitination.

Cell Biol Int 2020 Apr 14. Epub 2020 Apr 14.

Department of General Surgery, General Hospital of XinJiang Military Command, YouHaoBeiLu, Urumqi, Xinjiang, China.

Colorectal cancer (CRC) is the leading cause of cancer death, and its 5-year survival rate remains unsatisfactory. Recent studies have revealed that ubiquitin-specific protease 44 (USP44) is a cancer suppressor or oncogene depending on the type of neoplasm. However, its role in CRC remains unclear. Read More

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http://dx.doi.org/10.1002/cbin.11358DOI Listing

Knockdown of ghrelin-O-acyltransferase attenuates colitis through the modulation of inflammatory factors and tight junction proteins in the intestinal epithelium.

Cell Biol Int 2020 Apr 13. Epub 2020 Apr 13.

Department of Digestion, Shanghai Pudong Hospital, Shanghai, China.

Ghrelin-O-acyltransferase (GOAT) is a membrane-bound enzyme that attaches eight-carbon octanoate to a serine residue in ghrelin and thereby acylates inactive ghrelin to produce active ghrelin. In this study, we investigated the function of GOAT in the intestinal mucosal barrier. The intestinal mucosal barrier prevents harmful substances such as bacteria and endotoxin from entering the other tissues, organs, and blood circulation through the intestinal mucosa. Read More

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http://dx.doi.org/10.1002/cbin.11362DOI Listing

New insights into small-cell lung cancer development and therapy.

Cell Biol Int 2020 Apr 13. Epub 2020 Apr 13.

Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, Guangdong, China.

Small-cell lung cancer (SCLC) accounts for approximately 15% of lung cancer cases; however, it is characterized by easy relapse and low survival rate, leading to one of the most intractable diseases in clinical practice. Despite decades of basic and clinical research, little progress has been made in the management of SCLC. The current standard first-line regimens of SCLC still remain to be cisplatin or carboplatin combined with etoposide, and the adverse events of chemotherapy are by no means negligible. Read More

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http://dx.doi.org/10.1002/cbin.11359DOI Listing

LINC00667 promotes the proliferation, migration, and pathological angiogenesis in non-small cell lung cancer through stabilizing VEGFA by EIF4A3.

Cell Biol Int 2020 Apr 13. Epub 2020 Apr 13.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

To better treat patients with non-small cell lung cancer (NSCLC), the investigations on novel molecules affecting NSCLC progression are of vital importance. Long noncoding RNAs (lncRNAs) are identified as pivotal regulators that can affect the cellular activities of carcinomas. Long intergenic non-protein coding RNA 667 (LINC00667) is a newly found lncRNA, and its expression pattern and potent mechanisms are still obscure in NSCLC. Read More

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http://dx.doi.org/10.1002/cbin.11361DOI Listing