2,223 results match your criteria Cell biochemistry and function[Journal]


Functional analysis of mesencephalic astrocyte-derived neurotrophic factor in retinal ganglion cells under oxidative stress.

Cell Biochem Funct 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

Glaucoma is optic neuropathy that is characterized by progressive neurodegeneration of the retinal ganglion cells (RGCs) and axons. This condition will lead to visual impairment and bring glaucoma to become the second cause of blindness globally. Neuroprotection in glaucoma is needed to prevent the progression of optic neuropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3567DOI Listing

Characterization of antiapoptotic microRNAs in primary Sjögren's syndrome.

Cell Biochem Funct 2020 Jun 23. Epub 2020 Jun 23.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

During the development of primary Sjögren's syndrome (pSS), aberrant expression of autoantigen is a hallmark event. To explore the regulation of autoantigen tripartite motif containing 21 (Ro/SSA, TRIM21), microRNA profiling was performed in our previous study. In which, two TRIM21-targeting microRNAs were identified, namely miR-1207-5p and miR-4695-3p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3569DOI Listing
June 2020
2.005 Impact Factor

HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase.

Cell Biochem Funct 2020 Jun 21. Epub 2020 Jun 21.

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan.

Heat shock protein 90 (HSP90) is expressed ubiquitously in a variety of cell types including osteoblasts. HSP90 acts as a key driver of proteostasis under pathophysiological conditions. Here, we investigated the involvement of HSP90 in extracellular ATP-stimulated interleukin (IL)-6 synthesis and HSP90 downstream signalling in osteoblast-like MC3T3-E1 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3566DOI Listing

Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.

Cell Biochem Funct 2020 Jun 21. Epub 2020 Jun 21.

Guangxi Medical University, Nanning, China.

The present study was to investigate the inhibitory effect and underlying mechanism of Tormentic acid (TA) on hepatic stellate cells (HSCs). HSC-T6 cells were stimulated with Platelet-derived growth factor-BB (PDGF-BB) and TA, and then cell proliferation, apoptosis, inflammatory factor, and collagen-related indicators were detected. In order to elucidate the potential mechanism, the PI3K/Akt/mTOR and NF-κB signalling pathways were also detected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3564DOI Listing
June 2020
2.005 Impact Factor

Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells.

Cell Biochem Funct 2020 Jun 11. Epub 2020 Jun 11.

Core Protein Resources Center, DGIST, Daegu, South Korea.

Mouse embryonic stem cells (mESCs) are pluripotent cells that possess the ability to self-renew and differentiate into three germ layers. Owing to these characteristics, mESCs act as important models for stem cell research and are being used in many clinical applications. Among the many cathepsins, cathepsin A (Ctsa), a serine protease, affects the function and properties of stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3554DOI Listing
June 2020
2.005 Impact Factor

Comparative profiles of DNA methylation and differential gene expression in osteocytic areas from aged and young mice.

Cell Biochem Funct 2020 Jun 11. Epub 2020 Jun 11.

Department of Prosthodontics, School and Hospital of Stomatology, Tongji University and Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

Altered DNA methylation upon ageing may result in many age-related diseases such as osteoporosis. However, the changes in DNA methylation that occur in cortical bones, the major osteocytic areas, remain unknown. In our study, we extracted total DNA and RNA from the cortical bones of 6-month-old and 24-month-old mice and systematically analysed the differentially methylated regions (DMRs), differentially methylated promoters (DMPs) and differentially expressed genes (DEGs) between the mouse groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3539DOI Listing

LINC00240 promotes gastric cancer cell proliferation, migration and EMT via the miR-124-3p / DNMT3B axis.

Cell Biochem Funct 2020 Jun 11. Epub 2020 Jun 11.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Gastric cancer (GC) remains one of prevalent causes of cancer-related deaths worldwide. Long noncoding RNA is related to various cancers. Our study was conducted to explore the biological effects of LINC00240 on the tumorigenesis of GC and uncover its possible mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3551DOI Listing

Overexpression of microRNA-23a-5p induces myocardial infarction by promoting cardiomyocyte apoptosis through inhibited of PI3K/AKT signalling pathway.

Cell Biochem Funct 2020 Jun 9. Epub 2020 Jun 9.

Department of Cardiothoracic surgery, Huashan Hospital of Fudan University, Shanghai, China.

Myocardial infarction (MI) leads to cardiac remodelling and heart failure. Cardiomyocyte apoptosis is considered a critical pathological phenomenon accompanying MI, but the pathogenesis mechanism remains to be explored. MicroRNAs (miRs), with the identity of negative regulator of gene expression, exist as an important contributor to apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3536DOI Listing

Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-κB/COX2 signal pathway in breast cancer cell.

Cell Biochem Funct 2020 Jun 8. Epub 2020 Jun 8.

Department of Ophthalmology, Jincheng People's Hospital, Shanxi Province, China.

Malignant phenotypes are leading causes of death in patients with breast cancer (BC). Previously, it has been proved that tubulin polymerization promoting protein 3 (TPPP3) participates in cell progressions in several human cancers. Little is known about the functions of TPPP3 in BC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3546DOI Listing

Changes of Endocan and its effect on hepatic stem cells during the rapid proliferation process of residual liver after ALPPS procedure.

Cell Biochem Funct 2020 Jun 8. Epub 2020 Jun 8.

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

To establish a stable animal model of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), as well as to explore whether Endocan and HGF/c-Met signalling pathway participate in the regeneration of residual liver through hepatic stem cells after ALPPS procedure. C57BL/6J male mice weighing 18-22 g were used in this study. The liver regeneration index was expressed as the ratio of Future Liver Remnant (FLR)/Body weight (BW) × 100%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3553DOI Listing
June 2020
2.005 Impact Factor

MiRNAs as potential biomarker of kidney diseases: A review.

Cell Biochem Funct 2020 Jun 4. Epub 2020 Jun 4.

Department of Nephrology, Kidney Care, Tiruchirappalli, India.

MicroRNAs (miRNAs) are 22 nucleotides short, non-coding and tissue-specific single-stranded RNA which modulates target gene expression. Presently, shreds of evidence confirmed that miRNAs play a key role in kidney pathophysiology. The objectives of the present review are to summarize new research data towards the latest developments in the potential use of miRNAs as a diagnostic biomarker for kidney diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3555DOI Listing

microRNA-124-3p inhibits tumourigenesis by targeting mitogen-activated protein kinase 4 in papillary thyroid carcinoma.

Cell Biochem Funct 2020 Jun 3. Epub 2020 Jun 3.

Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

The study aimed to investigate the role of miR-124-3p and its potential molecular mechanism in papillary thyroid cancer (PTC). The expression of miR-124-3p and mitogen-activated protein kinase 4 (MAP2K4) in human thyroid follicular epithelial cell line (NTHY-ORI3-1) and human papillary thyroid carcinoma cell lines (SW1736, BCPAP, TPC-1 and K1) was measured by RT-qPCR. Cell proliferation was measured by CCK-8, while cell cycle and apoptosis rate were measured by flow cytometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3532DOI Listing

Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.

Cell Biochem Funct 2020 May 31. Epub 2020 May 31.

Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, People's Republic of China.

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer, and thymidine phosphorylase (TP) is a regulator of angiogenesis. To investigate the biological activities of TP in ICC, we established human cholangiocarcinoma RBE cell lines overexpressing TP or silencing TP. Overexpression of TP enhanced viability, suppressed apoptosis and increased tube formation in human umbilical vein endothelial cells, while downregulation of TP reversed these effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3541DOI Listing

MiR-302b-5p enhances the neuroprotective effect of IGF-1 in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease by regulating inducible nitric-oxide synthase.

Cell Biochem Funct 2020 May 31. Epub 2020 May 31.

Affiliated Hospital of Xiangnan University, Chenzhou, China.

Parkinson's disease (PD) is a neurodegenerative disease which results in damage in neuronal cells. Insulin-like growth factor (IGF)-1 was previously reported to play a role of neuroprotection in some diseases. Nitric oxide (NO) can also regulate neuronal cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3534DOI Listing

Differential mechanisms of autophagy in cancer stem cells: Emphasizing gastrointestinal cancers.

Cell Biochem Funct 2020 May 28. Epub 2020 May 28.

Cellular Genetics Laboratory, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan.

Gastrointestinal (GI) cancers are one of the most common forms of malignancies and still are the most important cause of cancer-related mortality worldwide. Autophagy is a conserved catabolic pathway involving lysosomal degradation and recycling of whole cellular components, which is essential for cellular homeostasis. For instance, it acts as a pivotal intracellular quality control and repair mechanism but also implicated in cell reformation during cell differentiation and development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3552DOI Listing

CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro.

Cell Biochem Funct 2020 May 26. Epub 2020 May 26.

Department of Gynecology and Obstetrics, First Affiliated Hospital of Dalian Medical University, Dalian, China.

For successful implantation, endometrial receptivity must be established. The high expression of CDC20 in many kinds of malignant tumours has been reported, and it is related to the occurrence and development of tumours. According to these functions, we think that CDC20 may also play important roles in the process of embryo implantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3550DOI Listing

Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.

Cell Biochem Funct 2020 May 20. Epub 2020 May 20.

Provincial Clinical Medical College of Fujian Medical University, Fuzhou, China.

The current study investigated the role of mesenchymal stem cells (MSCs) in repairing senile bone marrow injury and the underlying mechanism. Adenoviral vectors expressing green fluorescent protein (GFP) were used to label MSCs. The level of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) were detected by thiobarbituric acid (TBA) and xanthine oxidation (XTO) methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3548DOI Listing
May 2020
2.005 Impact Factor

Long non-coding RNA FAM66C is associated with clinical progression and promotes cell proliferation by inhibiting proteasome pathway in prostate cancer.

Cell Biochem Funct 2020 May 19. Epub 2020 May 19.

Department of Urology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Prostate cancer is the most prevalent malignancy in men, and the identification of novel oncogenes is clinically valuable for early screening, prevention and treatment. Recently, the studies have revealed that long non-coding RNAs (lncRNAs) play important roles in the development and progression of cancers including prostate cancer. The present study aims to identify a novel lncRNA that correlated with the survival time of prostate cancer patients and try to explore its biological functions in prostate cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3531DOI Listing

DMBT1 suppresses cell proliferation, migration and invasion in ovarian cancer and enhances sensitivity to cisplatin through galectin-3/PI3k/Akt pathway.

Authors:
Nan Ma Yuqing Zhao

Cell Biochem Funct 2020 May 19. Epub 2020 May 19.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Ovarian cancer (OC) is one of the most common gynaecologic malignancies. Deleted in malignant brain tumors 1 (DMBT1) was considered as a tumour suppressor in multiple cancers, but there have been no systemic profiling studies of DMBT1 in OC until now. The aim of this study is to explore the role and the potential mechanism of DMBT1 in OC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3549DOI Listing

A-kinase-interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer.

Cell Biochem Funct 2020 May 13. Epub 2020 May 13.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Overexpression of A-kinase-interacting protein 1 (AKIP1) has been reported in prostate and breast cancers. Nevertheless, the clinical potential of AKIP1 during the development of cervical cancer (CC) remains unclear. A series of experiments involving BdU, colony formation, wound healing and cell invasion assays were performed to determine cell proliferation, migration and invasion, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3547DOI Listing

STAT1 determines aggressiveness of glioblastoma both in vivo and in vitro through wnt/β-catenin signalling pathway.

Cell Biochem Funct 2020 May 10. Epub 2020 May 10.

Department of Neurosurgery, Jiming No. 1 People's Hospital, Jining, Shandong, China.

Glioblastoma is one of the most malignant tumors and causes the high mortality in cancer patients. Currently, there is no highly efficient therapy against glioblastoma. Therefore, searching for a new molecular target to anti-glioblastoma therapy is urgent and necessary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3518DOI Listing

LncRNA TUG1 facilitates proliferation, invasion and stemness of ovarian cancer cell via miR-186-5p/ZEB1 axis.

Cell Biochem Funct 2020 May 11. Epub 2020 May 11.

Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

LncRNA TUG1 has been rarely studied in ovarian cancer (OC), our objective was to explore the role of TUG1 in the regulation of malignant phenotypes of OC. Vectors of sh-TUG1, miR-186-5p and pcDNA-ZEB1 were, respectively, constructed and used to infect OC cells. MTT and transwell assays were applied for representing cell proliferation and invasion, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3544DOI Listing

The roles of SHANK1 in the development of colon cancer.

Cell Biochem Funct 2020 Apr 30. Epub 2020 Apr 30.

Department of Gastroenterological Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.

SH3 and multiple ankyrin repeat domains protein 1 (SHANK1) belongs to a family of postsynaptic scaffolding proteins. In this study, we found that SHANK1 was abnormally high expressed in colon cancer tissues compared to normal tissues. Colon cancer patients with low SHANK1 expression had better prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3529DOI Listing

The key candidate genes in tubulointerstitial injury of chronic kidney diseases patients as determined by bioinformatic analysis.

Cell Biochem Funct 2020 Apr 27. Epub 2020 Apr 27.

Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.

Pathologic changes such as renal tubular atrophy and interstitial fibrosis are common in chronic kidney disease (CKD), which in turn, leads to loss of renal function. The aims of present study were to screen critical genes with tubulointerstitial lesion in CKD by weighted gene correlation network analysis (WGCNA). Gene expression data including 169 tubulointerstitial samples of CKD and 21 controls downloaded from Gene Expression Omnibus (GEO) database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3545DOI Listing

Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.

Cell Biochem Funct 2020 Apr 23. Epub 2020 Apr 23.

Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.

Growing data have recognized the significance of Response Gene to Complement (RGC)-32 in numerous tumour developments. Notwithstanding, the functional role and underlying mechanism of it in tongue squamous cell carcinoma (TSCC) remain enigmatic. Here, to identify the impact of RGC-32 in TSCC, its expression in multiple TSCC cells was measured and loss-of-function experiments in cell lines were performed to illuminate the function of it induced TSCC progression, via si-RNA knockdown, CCK-8, colony formation, wound-healing, transwell, flow cytometry and western blot assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3520DOI Listing

CircRNA-0077930 from hyperglycaemia-stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells.

Cell Biochem Funct 2020 Apr 19. Epub 2020 Apr 19.

Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

Vascular smooth muscle aging leads to diabetic complications such as cardiovascular and kidney diseases or diabetic foot. Therefore, understanding the mechanism of smooth muscle cell senescence in a high-glucose (HG) environment is essential. The purpose of this study was to determine whether and how circRNA from human umbilical vein endothelial cell exosomes (HUVEC-Exos) under HG conditions regulates the senescence of vascular smooth muscle cells (VSMCs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3543DOI Listing
April 2020
2.005 Impact Factor

Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca homeostasis.

Cell Biochem Funct 2020 Apr 19. Epub 2020 Apr 19.

Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS-IV) exerts multiple protective effects in diverse diseases. However, whether AS-IV can attenuate CIH-induced myocardial injury is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3538DOI Listing

Retinoic acid induced 16 deficiency exacerbates high-fat diet-induced steatohepatitis in mice.

Cell Biochem Funct 2020 Apr 14. Epub 2020 Apr 14.

Department of Microbiology, Second Military Medical University, Shanghai, China.

Non-alcoholic fatty liver disease (NAFLD) associated with obesity may progress to non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma (HCC). Retinoic acid induced 16 (RAI16) plays an important role in cell apoptosis and is also a potential marker for HCC. Here we aimed to test the effect of RAI16 deficiency on liver pathology in high-fat diet (HFD) fed mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3542DOI Listing
April 2020
2.005 Impact Factor

CASC5 is a potential tumour driving gene in lung adenocarcinoma.

Cell Biochem Funct 2020 Apr 13. Epub 2020 Apr 13.

School of Life Sciences, Zhengzhou University, Zhengzhou, China.

Previous studies have shown that cancer susceptibility candidate 5 (CASC5) plays important roles in several types of cancer. But its expression and clinical significance in human pan-cancer remain largely unclear. In the present study, we comprehensively analysed the expression profile and prognostic values of CASC5 in pan-cancer across 33 cancer types based on the online TCGA analysis databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3540DOI Listing

DGUOK-AS1 promotes cell proliferation in cervical cancer via acting as a ceRNA of miR-653-5p.

Cell Biochem Funct 2020 Apr 13. Epub 2020 Apr 13.

Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.

Cervical cancer (CC) holds the second highest incidence and is the fourth dominating cause of cancer-induced death in women. It has been widely accepted that long noncoding RNAs (lncRNAs) are implicated in pathological and physiological activities of CC. However, the research of lncRNAs is still in the initial stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3506DOI Listing

Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.

Cell Biochem Funct 2020 Apr 13. Epub 2020 Apr 13.

Digestive System Department, First Affiliated Hospital of Gannan Medical University, Ganzhou, People's Republic of China.

Gastric cancer (GC) is one of the most prevalent types of malignancies. Betulinic acid (BA) is a natural pentacyclic triterpene with a lupine structure. However, to the best of our knowledge, there is no research study on the anti-tumour and anti-metastasis effect of BA on GC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3537DOI Listing

Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis.

Cell Biochem Funct 2020 Apr 7. Epub 2020 Apr 7.

Department of Ophthalmology, Heze Municipal Hospital, Heze, China.

Retinoblastoma (RB) is one of the most common primary intraocular malignancies in children. Emerging researches have shown that circular RNAs (circRNAs) play critical roles in a variety of cancers. As a novel circRNA, the function of circ_0000527 in RB remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3535DOI Listing

WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.

Cell Biochem Funct 2020 Apr 5. Epub 2020 Apr 5.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

E3 ubiquitin ligase gene, WWP2, is associated with acute kidney injury (AKI). This research was conducted to explore the role of WWP2 in AKI. AKI cell model was produced in human renal proximal tubular epithelial cell line (HK-2) by ischemia-reperfusion (IR) injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3533DOI Listing

Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel.

Cell Biochem Funct 2020 Apr 1. Epub 2020 Apr 1.

Department of Endodontics, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Invasion of dentinal tubules and pulp tissue by pathogenic bacteria may cause infection leading to pulpitis. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase encoded by the SIRT6 gene. The effect of SIRT6 on lipopolysaccharide (LPS)-induced pulpitis and its mechanism of action were discussed in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3528DOI Listing

Wnt signalling pathway and tau phosphorylation: A comprehensive study on known connections.

Cell Biochem Funct 2020 Mar 31. Epub 2020 Mar 31.

Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The Wnt pathway is the most important cascade in the nervous system; evidence has indicated that deregulation of the Wnt pathway induced pathogenic hallmarks of neurodegenerative diseases. Glycogen synthase kinase-3β (GSK-3β) as the main member of the Wnt pathway increases tau inclusions, the main marker in the neurodegenerative diseases. Phosphorylated tau is observed in the pre-tangle of the neurons in the early stage of neurodegenerative diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3530DOI Listing

Knockdown of long non-coding RNA Gm10804 suppresses disorders of hepatic glucose and lipid metabolism in diabetes with non-alcoholic fatty liver disease.

Cell Biochem Funct 2020 Mar 24. Epub 2020 Mar 24.

Department of Endocrinology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.

Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with diabetes mellitus (DM) and non-alcoholic fatty liver disease (NAFLD). This study aims to investigate the role of Gm10804, a novel long non-coding RNA (lncRNA), in regulating hepatic glucose and lipid metabolism in DM complicated with NAFLD (DM-NAFLD). Mouse primary hepatocytes exposed to high glucose (HG) were used as a cell model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3495DOI Listing

Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.

Cell Biochem Funct 2020 Mar 24. Epub 2020 Mar 24.

Pediatric Surgery Department, Medical University of Bialystok, Bialystok, Poland.

Ubiquitin C-terminal hydrolase 1 (UCHL1) is an enzyme unique for its multiple activity - both ligase and hydrolase. UCHL1 was first identified as an abundant protein found in the brain and testes, however its expression is not limited to the neuronal compartment. UCHL1 is also highly expressed in carcinomas of various tissue origins, including those from brain, lung, breast, kidney, colon, prostate, pancreas and mesenchymal tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3527DOI Listing

Mitochondrial apoptosis and curtailment of hypoxia-inducible factor-1α/fatty acid synthase: A dual edge perspective of gamma linolenic acid in ER+ mammary gland cancer.

Cell Biochem Funct 2020 Mar 23. Epub 2020 Mar 23.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, Uttar Pradesh, India.

Gamma linolenic acid is a polyunsaturated fatty acid having selective anti-tumour properties with negligible systemic toxicity. In the present study, the anti-cancer potential of gamma linolenic acid and its effects on mitochondrial as well as hypoxia-associated marker was evaluated. The effect of gamma linolenic acid was scrutinised against ER + MCF-7 cells by using fluorescence microscopy, JC-1 staining, dot plot assay and cell cycle analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3513DOI Listing
March 2020
2.005 Impact Factor

TSPAN31 suppresses cell proliferation in human cervical cancer through down-regulation of its antisense pairing with CDK4.

Cell Biochem Funct 2020 Mar 23. Epub 2020 Mar 23.

Department of Biochemistry and Molecular Biology, GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, PR China.

Natural antisense transcripts (NAT) are prevalent phenomena in the mammalian genome and play significant regulatory roles in gene expression. While new insights into NAT continue to be revealed, their exact function and their underlying mechanisms in human cancer remain largely unclear. We identified a NAT of CDK4, referred to TSPAN31, which inhibits CDK4 mRNA and protein expression in human cervical cancer by targeting the 3'-untranslated region (3'-UTR) of the CDK4 mRNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3526DOI Listing

LncRNA DLEU2 promotes tumour growth by sponging miR-337-3p in human osteosarcoma.

Cell Biochem Funct 2020 Mar 20. Epub 2020 Mar 20.

Department of Spine Surgery, The First Hospital of Jilin University, Jilin, China.

According to statistics, abnormal regulation of lncRNAs pivotally influences multiple malignant tumours. DLEU2, as one of these lncRNAs, is detected to be related to growth and development of tumours. The molecular mechanisms of DLEU2 in osteosarcoma, however, are still unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3509DOI Listing

miR-21-3p regulates AGE/RAGE signalling and improves diabetic atherosclerosis.

Cell Biochem Funct 2020 Mar 20. Epub 2020 Mar 20.

Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

To explore the effects of miR-21-3p on diabetic atherosclerosis. Using enzyme-linked immunosorbent assay (ELISA), we also detected the levels of soluble receptor for advanced glycation endproducts RAGE (sRAGE) in the cellular supernatant of vascular endothelial cells after transfecting them with adenovirus vector having miR-21-3p mimic or inhibitor. We found decrease in the expression levels of miR-21-3p in vascular endothelial cells (VECs) induced by high-concentration glucose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3523DOI Listing
March 2020
2.005 Impact Factor

Dual in vitro invasion/migration suppressing and tamoxifen response modulating effects of a recombinant anti-ALCAM scFv on breast cancer cells.

Cell Biochem Funct 2020 Mar 20. Epub 2020 Mar 20.

Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.

It has been shown that overexpression of activated leukocyte cell adhesion molecule (ALCAM) is involved in development of resistance to tamoxifen therapy and promotion of cell invasion, migration and metastasis in ER+ breast cancer cells. Thus, we hypothesized that blockade of ALCAM interconnections with antibodies could be an effective approach for reversing mentioned negative events associated with ALCAM overexpression in breast cancer cells. Here, an anti-ALCAM scFv was recombinantly expressed and used throughout study for examination of the putative anticancer effects of ALCAM blockade. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3525DOI Listing

LncRNA CYTOR attenuates sepsis-induced myocardial injury via regulating miR-24/XIAP.

Cell Biochem Funct 2020 Mar 17. Epub 2020 Mar 17.

Intensive Care Unit, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Heifei, China.

This work aims to investigate the function and mechanism of long non-coding RNA (lncRNA) cytoskeleton regulator RNA (CYTOR) in myocardial injury induced by sepsis. The sepsis-induced myocardial injury model in mice was established by intraperitoneal injection of LPS (10 mg/kg) in vivo, and cardiomyocyte H9c2 was treated with LPS to mimic sepsis in vitro. CYTOR expression and miR-24 expression were detected by qRT-PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3524DOI Listing

Targeted inhibition of ACK1 can inhibit the proliferation of hepatocellular carcinoma cells through the PTEN/AKT/mTOR pathway.

Cell Biochem Funct 2020 Mar 12. Epub 2020 Mar 12.

Department of Pathology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China.

Activated Cdc42-associated kinase 1 (ACK1) expression is upregulated in hepatocellular carcinoma (HCC) tissues and other tumour tissues. However, the function and regulatory mechanism of ACK1 in HCC remains unclear. In this study, the expression of pTyr284-ACK1, pSer473-AKT and PTEN in HCC was detected by immunohistochemistry, and its clinicopathological significance was analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3522DOI Listing

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR-744-3p/YY1 signalling.

Cell Biochem Funct 2020 Mar 11. Epub 2020 Mar 11.

Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.

Long non-coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. High expression of LINC00899 in AML cells could promote cell proliferation and inhibit cell apoptosis, and facilitate the progression of AML consequently both in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3521DOI Listing

Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.

Cell Biochem Funct 2020 Mar 9. Epub 2020 Mar 9.

Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang, China.

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most frequent cause of cancer-related death. The IRX5 transcription factor plays a different role in multiple cancers and contributes to the development of many tumours. However, little is known about the molecular mechanisms of IRX5 in HCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3517DOI Listing
March 2020
2.005 Impact Factor

Overexpression of long non-coding RNA RP11-363E7.4 inhibits proliferation and invasion in gastric cancer.

Cell Biochem Funct 2020 Mar 5. Epub 2020 Mar 5.

Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, China.

LncRNA RP11-363E7.4 has been shown to be downregulated in gastric cancer (GC), while the effect of lncRNA RP11-363E7.4 on GC and its potential molecular mechanisms is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3514DOI Listing

CircRNA_0005075 suppresses carcinogenesis via regulating miR-431/p53/epithelial-mesenchymal transition axis in gastric cancer.

Cell Biochem Funct 2020 Mar 4. Epub 2020 Mar 4.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, China.

This study was aimed to explore the expression and biological function of circRNA_0005075 in gastric cancer (GC) progression and its underlying mechanism. First, the expression level of circRNA_0005075 and microRNA-431 (miR-431) in GC tissues were detected with the quantitative real-time polymerase chain reaction. In addition, after down-regulated the circRNA_0005075 expression by plasmid transfection in GC cells, the Cell Counting Kit-8 (CCK-8), EDU, transwell assay were conducted to evaluate the function of circRNA_0005075 or miR-431 on cell proliferation, metastasis in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3519DOI Listing

MicroRNA targeting of the non-canonical planar cell polarity pathway in the developing neural tube.

Cell Biochem Funct 2020 Mar 4. Epub 2020 Mar 4.

Division of Craniofacial Development and Anomalies, Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, Kentucky, USA.

MicroRNAs (miRNAs) provide context-dependent transcriptional regulation of genes comprising signalling networks throughout the developing organism including morphogenesis of the embryonic neural tube (NT). Using a high-sensitivity, high-coverage microarray analysis platform, miRNA expression in the murine embryonic NT during the critical stages of its formation was examined. Analysis of a number of differentially expressed (DE) miRNAs enabled identification of several gene targets associated with cellular processes essential for normal NT development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3512DOI Listing

LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR-320/S100A10 axis.

Cell Biochem Funct 2020 Mar 3. Epub 2020 Mar 3.

Department of Blood Transfusion, Affiliated Hospital of Xiangnan University, Chenzhou, China.

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Multiple long non-coding RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumour suppressors. In this study, we explored the effects of LINC00174 on the progression of HCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3498DOI Listing