3,268 results match your criteria Cell Transplantation[Journal]


Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.

Cell Transplant 2019 Feb 18:963689719831707. Epub 2019 Feb 18.

1 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

As a putative marker of cerebral small vessel disease, cerebral microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression of CMBs, but their cross-talk is not yet understood. In this study, we found a profound increase of amyloid formation with increasing FeCl treatment, and a distinct change in APP metabolism and expression of iron homeostasis proteins (ferritin, Fpn1, iron regulatory protein) was observed at the 300 uM concentration of FeCl. Read More

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http://dx.doi.org/10.1177/0963689719831707DOI Listing
February 2019

Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis.

Cell Transplant 2019 Feb 11:963689719829073. Epub 2019 Feb 11.

1 Department of Neurosurgery, Comprehensive Surgical Laboratory, Affiliated Hospital of Nantong University, P.R. China.

Neuronal apoptosis is regarded as one of the most important pathophysiological changes of intracerebral hemorrhagic (ICH) stroke-a major public health problem that leads to high mortality rates and functional dependency. Mitogen-and stress-activated kinase (MSK) 1 is implicated in various biological functions in different cell types, including proliferation, tumorigenesis and responses to stress. Our previous study showed that MSK1 phosphorylation (p-MSK1) is related to the regulation of LPS-induced astrocytic inflammation, and possibly acts as a negative regulator of inflammation. Read More

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http://dx.doi.org/10.1177/0963689719829073DOI Listing
February 2019

Construction of Pedicled Smooth Muscle Tissues by Combining the Capsule Tissue and Cell Sheet Engineering.

Cell Transplant 2019 Jan 9:963689718821682. Epub 2019 Jan 9.

1 Department of Urology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

The survival of engineered tissue requires the formation of its own capillary network, which can anastomose with the host vasculature after transplantation. Currently, while many strategies, such as modifying the scaffold material, adding endothelial cells, or angiogenic factors, have been researched, engineered tissue implanted in vivo cannot timely access to sufficient blood supply, leading to ischemic apoptosis or shrinkage. Constructing vascularized engineered tissue with its own axial vessels and subsequent pedicled transfer is promising to solve the problem of vascularization in tissue engineering. Read More

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http://dx.doi.org/10.1177/0963689718821682DOI Listing
January 2019

Targeting MicroRNA-21 Suppresses Gastric Cancer Cell Proliferation and Migration via PTEN/Akt Signaling Axis.

Cell Transplant 2019 Jan 30:963689719825573. Epub 2019 Jan 30.

1 Department of Gastroenterology, Jinshan Hospital of Fudan University, Shanghai, China.

MicroRNA plays a pivotal role in various human cancers, especially in human gastric cancer. In the present study, we evaluated the effect of microRNA-21 (miR-21) on the gastric cancer cell proliferation, migration, apoptosis and the related signaling cascades. Here, we showed that down-regulation of miR-21 markedly reduced gastric cancer cell proliferation (AGS and NCI-N87 cells) in a time dependent manner. Read More

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http://dx.doi.org/10.1177/0963689719825573DOI Listing
January 2019
3.570 Impact Factor

Intravesical Administration of Xenogeneic Porcine Urothelial Cells Attenuates Cyclophosphamide-Induced Cystitis in Mice.

Cell Transplant 2019 Jan 24:963689718822773. Epub 2019 Jan 24.

1 Departments of Medical Laboratory Science and Biotechnology and Urology, Sex Hormone Research Center, China Medical University and Hospital, Taichung.

The urothelium of the bladder, renal pelvis, ureter and urethra is maintained through the regulated proliferation and differentiation of urothelial stem and progenitor cells. These cells provide a rich source of a novel urothelial cell therapy approach that could be used to protect, regenerate, repair and restore a damaged urothelium. Urothelial injury caused by physical, chemical and microbial stress is the pathological basis of cystitis (bladder inflammation). Read More

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http://journals.sagepub.com/doi/10.1177/0963689718822773
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http://dx.doi.org/10.1177/0963689718822773DOI Listing
January 2019
5 Reads

Steroid-Free Immune Suppression Impairs Glycemic Control in a Healthy Cynomolgus Monkey.

Cell Transplant 2019 Jan 24:963689718823505. Epub 2019 Jan 24.

1 Diabetes Research Institute, Miller School of Medicine, University of Miami, FL, USA.

The need for chronic immune suppression (IS) is one of the hurdles precluding widespread use of islet cell transplantation to restore glycemic control in patients with type 1 diabetes. We report the case of a healthy nonhuman primate (NHP) treated on and off for over 2.5 years with steroid-free IS, consisting of daclizumab induction and maintenance therapy with rapamycin and low dose tacrolimus. Read More

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http://dx.doi.org/10.1177/0963689718823505DOI Listing
January 2019

Ginsenoside Rg1 Accelerates Paracrine Activity and Adipogenic Differentiation of Human Breast Adipose-Derived Stem Cells in a Dose-Dependent Manner In Vitro.

Cell Transplant 2019 Jan 24:963689719825615. Epub 2019 Jan 24.

4 Department of Plastic and Aesthetic Surgery, The Fifth Affiliated Hospital of Guangxi Medical University & The First People's Hospital of Nanning, Nanning, China.

Augmenting the biological function of adipose-derived stromal cells (ASCs) is a promising approach to promoting tissue remodeling in regenerative medicine. Here, we examined the effect of ginsenoside Rg1 on the paracrine activity and adipogenic differentiation capacity of human breast ASCs (hbASCs) in vitro. hbASCs were isolated and characterized in terms of stromal cell surface markers and multipotency. Read More

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http://dx.doi.org/10.1177/0963689719825615DOI Listing
January 2019
3 Reads

Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin (DADLE) Exerts a Cytoprotective Effect in Astrocytes Exposed to Oxygen-Glucose Deprivation by Inducing Autophagy.

Cell Transplant 2019 Jan 22:963689719825619. Epub 2019 Jan 22.

1 Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, China.

Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although the mechanism remains unclear. The present study aimed to test the effect of DOR activation on autophagy in astrocytes exposed to oxygen-glucose deprivation (OGD), and to further investigate whether this effect has a protective effect on astrocytes. Read More

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http://dx.doi.org/10.1177/0963689719825619DOI Listing
January 2019

Phenothiazines Enhance the Hypothermic Preservation of Liver Grafts: A Pilot in Vitro Study.

Cell Transplant 2019 Jan 22:963689718824559. Epub 2019 Jan 22.

3 Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.

In vitro liver conservation is an issue of ongoing critical importance in graft transplantation. In this study, we investigated the possibility of augmenting the standard pre-transplant liver conservation protocol (University of Wisconsin (UW) cold solution) with the phenothiazines chlorpromazine and promethazine. Livers from male Sprague-Dawley rats were preserved either in UW solution alone, or in UW solution plus either 2. Read More

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http://dx.doi.org/10.1177/0963689718824559DOI Listing
January 2019

Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review.

Cell Transplant 2019 Jan 22:963689718822782. Epub 2019 Jan 22.

4 Department of Physiology & Pharmacology, Loma Linda University School of Medicine, USA.

Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its clinical efficacy in patients with ischemic stroke is still uncertain. This review examines the recent knowledge of the neuroprotective properties of GM1 in ischemic stroke, collected in the past two decades. Read More

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http://dx.doi.org/10.1177/0963689718822782DOI Listing
January 2019
3.570 Impact Factor

Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi.

Cell Transplant 2019 Jan 18:963689718823206. Epub 2019 Jan 18.

1 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment with intravenous thrombolysis before MT) provides additional benefits in patients with middle cerebral artery (MCA) occlusion remains unclear. Therefore, this study aimed to compare the effects of direct MT and bridging therapy, and to elucidate the correlation between thrombus composition and stroke subtypes. Read More

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http://dx.doi.org/10.1177/0963689718823206DOI Listing
January 2019
2 Reads

The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury.

Cell Transplant 2019 Jan 18:963689718823705. Epub 2019 Jan 18.

1 Department of Tissue Culture and Stem Cells, Institute of Experimental Medicine, CAS, Prague, Czech Republic.

Spinal cord injury (SCI), is a devastating condition leading to the loss of locomotor and sensory function below the injured segment. Despite some progress in acute SCI treatment using stem cells and biomaterials, chronic SCI remains to be addressed. We have assessed the use of laminin-coated hydrogel with dual porosity, seeded with induced pluripotent stem cell-derived neural progenitors (iPSC-NPs), in a rat model of chronic SCI. Read More

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http://dx.doi.org/10.1177/0963689718823705DOI Listing
January 2019
2 Reads

Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?

Cell Transplant 2019 Jan 18:963689718824097. Epub 2019 Jan 18.

1 Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, USA.

Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise overview and discussion of five key themes that have become important considerations for rebuilding functional neural networks. The questions raised include: (i) who are the donor cells selected for transplantation, (ii) what is the intended target for repair, (iii) when is the optimal time for transplantation, (iv) where should the cells be delivered, and lastly (v) why does cell transplantation remain an attractive candidate for promoting neural repair after injury? Recent developments in neurobiology and engineering now enable us to start addressing these questions with multidisciplinary expertise and methods. Read More

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http://dx.doi.org/10.1177/0963689718824097DOI Listing
January 2019
1 Read

Treatment Strategy for Unruptured Intracranial Aneurysm in Elderly Patients: Coiling, Clipping, or Conservative?

Cell Transplant 2019 Jan 16:963689718823517. Epub 2019 Jan 16.

1 Division of Cerebrovascular Surgery and Interventional Neuroradiology, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

An increasing number of unruptured intracranial aneurysms (UIAs) has been discovered in elderly patients in recent years, but the optimal treatment strategy for these patients remains controversial. We report our six-year experience treating UIAs in elderly patients (≥ 70 years old). A retrospective review was conducted of elderly patients who harbored UIAs treated by conservative observation, microsurgical clipping, or endovascular coiling between January 2009 and December 2014. Read More

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http://dx.doi.org/10.1177/0963689718823517DOI Listing
January 2019
4 Reads

The Role of Hypoxia on the Neuronal Differentiation of Gingival Mesenchymal Stem Cells: A Transcriptional Study.

Cell Transplant 2019 Jan 14:963689718814470. Epub 2019 Jan 14.

1 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.

Mesenchymal stem cells (MSCs) are widely used in stem cell therapy for regenerative purposes. Oral-derived MSCs, such as gingival MSCs (GMSCs), deriving from the neural crest seem more suitable to differentiate toward the neuronal lineage. In addition, the preconditioning of MSCs may improve their beneficial effects. Read More

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http://dx.doi.org/10.1177/0963689718814470DOI Listing
January 2019
1 Read

Administration of rCTRP9 Attenuates Neuronal Apoptosis Through AdipoR1/PI3K/Akt Signaling Pathway after ICH in Mice.

Cell Transplant 2019 Jan 14:963689718822809. Epub 2019 Jan 14.

2 Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA.

Targeting neuronal apoptosis after intracerebral hemorrhage (ICH) may be an important therapeutic strategy for ICH patients. Emerging evidence indicates that C1q/TNF-Related Protein 9 (CTRP9), a newly discovered adiponectin receptor agonist, exerts neuroprotection in cerebrovascular disease. The aim of this study was to investigate the anti-apoptotic role of CTRP9 after experimental ICH and to explore the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1177/0963689718822809DOI Listing
January 2019
2 Reads

MRI Tracking of iPS Cells-Induced Neural Stem Cells in Traumatic Brain Injury Rats.

Cell Transplant 2018 Dec 21:963689718819994. Epub 2018 Dec 21.

2 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Induced pluripotent stem cells (iPS cells) are promising cell source for stem cell replacement strategy applied to brain injury caused by traumatic brain injury (TBI) or stroke. Neural stem cell (NSCs) derived from iPS cells could aid the reconstruction of brain tissue and the restoration of brain function. However, tracing the fate of iPS cells in the host brain is still a challenge. Read More

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http://dx.doi.org/10.1177/0963689718819994DOI Listing
December 2018
2 Reads

Transplantation of Human Neural Progenitor Cells (NPC) into Putamina of Parkinsonian Patients: A Case Series Study, Safety and Efficacy Four Years after Surgery.

Cell Transplant 2018 Dec 21:963689718820271. Epub 2018 Dec 21.

9 Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Individuals with Parkinson's disease (PD) suffer from motor and mental disturbances due to degeneration of dopaminergic and non-dopaminergic neuronal systems. Although they provide temporary symptom relief, current treatments fail to control motor and non-motor alterations or to arrest disease progression. Aiming to explore safety and possible motor and neuropsychological benefits of a novel strategy to improve the PD condition, a case series study was designed for brain grafting of human neural progenitor cells (NPCs) to a group of eight patients with moderate PD. Read More

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http://dx.doi.org/10.1177/0963689718820271DOI Listing
December 2018
1 Read

Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke.

Cell Transplant 2019 Feb 20;28(2):145-156. Epub 2018 Dec 20.

1 China-America Institute of Neuroscience, Luhe Hospital, Capital Medical University, Beijing, China.

Ischemic stroke destroys blood-brain barrier (BBB) integrity. There are currently no effective treatments available in the clinical setting. Post-ischemia treatment with phenothiazine drugs [combined chlorpromazine and promethazine (C+P)] has been shown to be neuroprotective in stroke. Read More

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http://dx.doi.org/10.1177/0963689718819443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362522PMC
February 2019
2 Reads

Progress and Updates in Stroke Research: Introduction to the Special Issue on Stroke.

Cell Transplant 2018 Dec;27(12):1709-1710

6 Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

As guest editors of this special issue, we are delighted to present 13 articles that discuss advances in stroke research including translational stroke research, stroke research milestones, and proposals for future directions. Stroke is a major cause of disability, and, according to the Centers for Disease Control and Prevention, is the fifth leading cause of death in the US alone. Possible factors contributing to stroke pathogenesis are elucidated and possible treatment modalities are explored in the following special issue of Cell Transplantation. Read More

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http://dx.doi.org/10.1177/0963689718816102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300769PMC
December 2018
1 Read
3.570 Impact Factor

Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union.

Cell Transplant 2019 Feb 17;28(2):212-223. Epub 2018 Dec 17.

1 Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shang Hai, P.R. China.

Bone non-union after fracture, considered a therapeutic challenge for orthopedics, always needs a reversion surgery, including autograft transplantation (AGT). However, adverse events related to autograft harvest cannot be ignored. Our group designed a novel system called the bone marrow stem cell Screen-Enrich-Combine Circulating System (SECCS) by seeding mesenchymal stem cells (MSCs) into β-tricalcium phosphate (β-TCP) during surgery to thereafter rapidly process bioactive bone implantation. Read More

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http://dx.doi.org/10.1177/0963689718818096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362520PMC
February 2019
2 Reads

The Diagnostic Utility of p16 Immunostaining in Differentiating Cancer and HSIL from LSIL and Benign in Cervical Cells.

Cell Transplant 2019 Feb 14;28(2):195-200. Epub 2018 Dec 14.

4 Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Cervical liquid-based cytology plays an important role in the diagnosis of cervical squamous intraepithelial lesion (SIL). However, cytological evaluation alone has a relatively low sensitive. To overcome this problem, HPV DNA testing or HPV DNA combined with cytology has been applied. Read More

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http://dx.doi.org/10.1177/0963689718817478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362523PMC
February 2019
2 Reads

The Efficacy of Near-Infrared Spectroscopy Monitoring in Carotid Endarterectomy: A Prospective, Single-Center, Observational Study.

Cell Transplant 2019 Feb 14;28(2):170-175. Epub 2018 Dec 14.

1 Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

There has been no gold standard for intraoperative monitoring in carotid endarterectomy (CEA) till now. The purpose of the current study was to investigate the value of near-infrared spectroscopy (NIRS) monitoring in CEA and explore the thresholds for intraoperative cerebral hypoperfusion. Eighty-four consecutive patients who underwent CEA surgery in Xuan Wu Hospital of Capital Medical University from August 2015 to June 2016 were enrolled in this study. Read More

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http://dx.doi.org/10.1177/0963689718817760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362521PMC
February 2019
2 Reads
3.570 Impact Factor

Age-Appropriateness of Porcine Models Used for Cell Transplantation.

Cell Transplant 2019 Feb 10;28(2):224-228. Epub 2018 Dec 10.

1 Department of Organ Fabrication, Keio University School of Medicine, Tokyo, Japan.

Pigs have traditionally been used for preclinical experiments, and body size-matching is important for cell therapy in animal models used for preclinical trials. It has been shown that the efficacy of the transplanted cells is dependent on the response of the host heart and the age of experimental pigs. Read More

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http://dx.doi.org/10.1177/0963689718817477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362526PMC
February 2019
1 Read

Potential of Exosomes for the Treatment of Stroke.

Cell Transplant 2018 Dec 6:963689718816990. Epub 2018 Dec 6.

1 Department of Anatomy, Histology and Embryology, Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain barrier (BBB), and their important role in communication between cells. Read More

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http://dx.doi.org/10.1177/0963689718816990DOI Listing
December 2018
20 Reads

Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center.

Cell Transplant 2019 Feb 6;28(2):185-194. Epub 2018 Dec 6.

1 Department of Surgery, University of Chicago, Chicago, IL, USA.

The selection of optimal pancreas donors is one of the key factors in determining the ultimate outcome of clinical islet isolation. North American Islet Donor Score (NAIDS) allows for estimating the chance of the success of islet isolation. It was developed based on the data from over 1000 donors from 11 islet isolation centers and validated in the University of Alberta, Edmonton, on the cohort from the most active islet transplant center. Read More

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http://dx.doi.org/10.1177/0963689718816989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362524PMC
February 2019
9 Reads
3.570 Impact Factor

Size, Aspect Ratio and Anatomic Location of Ruptured Intracranial Aneurysms: Consecutive Series of 415 Patients from a Prospective, Multicenter, Observational Study.

Cell Transplant 2018 Dec 4:963689718817227. Epub 2018 Dec 4.

1 Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

To analyze the size and location distribution of ruptured intracranial aneurysms (IAs) helps to provide evidence for clinical treatment of unruptured IAs using this feature of aneurysms. In this study, 415 patients who presented with an acute subarachnoid hemorrhage caused by IAs were enrolled from eight tertiary referral centers between June 2016 and March 2018. The size, aspect ratio and anatomic location of ruptured IAs were defined and reported by patient sex. Read More

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http://dx.doi.org/10.1177/0963689718817227DOI Listing
December 2018
2 Reads

Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro.

Cell Transplant 2018 Dec 4:963689718817219. Epub 2018 Dec 4.

1 Department of Neurosurgery, Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.

Although microRNA-144-3p (miRNA-144-3p) has been shown to suppress tumor proliferation and invasion, its function in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) remains unclear. Thus, this study was designed to investigate the role of miRNA-144-3p in ICH. To accomplish this, we used adult male Sprague-Dawley rats to establish an in vivo ICH model by injecting autologous blood, while cultured primary rat cortical neurons were exposed to oxyhemoglobin (OxyHb) to mimic ICH in vitro. Read More

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http://dx.doi.org/10.1177/0963689718817219DOI Listing
December 2018
10 Reads

Transplantation of Amniotic Fluid-Derived Stem Cells Preconditioned with Glial Cell Line-Derived Neurotrophic Factor Gene Alleviates Renal Fibrosis.

Cell Transplant 2019 Jan 30;28(1):65-78. Epub 2018 Nov 30.

1 Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Amniotic fluid-derived stem cells (AFSCs), which exhibit both embryonic and mesenchymal stem cell characteristics, have been shown to mitigate the degree of renal interstitial fibrosis. The aim of the present study was to determine whether transplantation of glial cell line-derived neurotrophic factor (GDNF)-modified AFSCs is more useful than transplantation of unmodified AFSCs for the treatment of renal interstitial fibrosis. Mice were randomly assigned to a sham-operation group (sham), a unilateral ureteral obstruction (UUO)-saline solution group (UUO), an AFSC transplantation group (AFSC) and a GDNF-modified AFSC transplantation group (GDNF-AFSC) and sacrificed at days 3 and 7 post-surgery (six in each group). Read More

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http://dx.doi.org/10.1177/0963689718815850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322139PMC
January 2019
6 Reads
3.570 Impact Factor

Inflammatory Smooth Muscle Cells Induce Endothelial Cell Alterations to Influence Cerebral Aneurysm Progression via Regulation of Integrin and VEGF Expression.

Cell Transplant 2018 Nov 30:963689718815824. Epub 2018 Nov 30.

1 Department of Neurosurgery, Huashan Hospital of Fudan University. Shanghai, China.

Cerebral aneurysm growth is characterized by vessel wall frailness, although the underlying cellular mechanisms are unclear. Here, we examined the relationship between inflammatory smooth muscle cells (SMCs) and endothelial cells (ECs) in cerebral aneurysms, including the mechanisms underlying inflammatory SMC-induced changes in ECs. Five saccular cerebral aneurysms were collected and five temporal artery samples were used as controls. Read More

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http://dx.doi.org/10.1177/0963689718815824DOI Listing
November 2018
1 Read

Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment.

Cell Transplant 2019 Jan 29;28(1):18-25. Epub 2018 Nov 29.

1 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g. Read More

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http://dx.doi.org/10.1177/0963689718815820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322135PMC
January 2019
10 Reads

Treatment of Naturally Degenerated Canine Lumbosacral Intervertebral Discs with Autologous Mesenchymal Stromal Cells and Collagen Microcarriers: A Prospective Clinical Study.

Cell Transplant 2019 Feb 29;28(2):201-211. Epub 2018 Nov 29.

2 Swiss Paraplegic Research, Nottwil, Switzerland.

Intervertebral disc (IVD) degeneration is a frequent disease in modern societies and at its later stages is likely to cause chronic low back pain. Although many studies have been published, the available treatments for IVD degeneration fail to promote regeneration or even marginal repair of the IVD structure. In this study, we aimed to establish veterinary canine patients as a translational large animal model that recapitulates IVD degeneration that occurs in humans, and to investigate the suitability of intradiscal application of mesenchymal stromal cells (MSC). Read More

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http://dx.doi.org/10.1177/0963689718815459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362527PMC
February 2019
2 Reads

Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1.

Cell Transplant 2019 Jan 26;28(1):79-88. Epub 2018 Nov 26.

1 Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Orthotopic liver transplantation remains the only curative therapy for inborn errors of metabolism. Given the tremendous success for primary immunodeficiencies using ex-vivo gene therapy with lentiviral vectors, there is great interest in developing similar curative therapies for metabolic liver diseases. We have previously generated a pig model of hereditary tyrosinemia type 1 (HT1), an autosomal recessive disorder caused by deficiency of fumarylacetoacetate hydrolase (FAH). Read More

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http://journals.sagepub.com/doi/10.1177/0963689718814188
Publisher Site
http://dx.doi.org/10.1177/0963689718814188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322137PMC
January 2019
9 Reads

Bioartificial Organ Manufacturing Technologies.

Authors:
Xiaohong Wang

Cell Transplant 2019 Jan 26;28(1):5-17. Epub 2018 Nov 26.

1 Department of Tissue Engineering, Center of 3D Printing and Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), Shenyang, Liaoning Province, P.R. China.

Bioartificial organ manufacturing technologies are a series of enabling techniques that can be used to produce human organs based on bionic principles. During the last ten years, significant progress has been achieved in the development of various organ manufacturing technologies. According to the degree of automation, organ manufacturing technologies can be divided into three main groups: (1) fully automated; (2) semi-automated; (3) handworked (or handmade); each has the advantages and disadvantages for bioartificial organ manufacturing. Read More

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http://dx.doi.org/10.1177/0963689718809918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322143PMC
January 2019
1 Read

The Protective Roles of Urinary Trypsin Inhibitor in Brain Injury Following Fat Embolism Syndrome in a Rat Model.

Cell Transplant 2018 Nov 19:963689718814766. Epub 2018 Nov 19.

2 Department of Anatomy and Histology, School of Basic Medical Sciences, Peking University, Beijing, China.

Fat embolism syndrome (FES) is a common complication following long bone fracture; fat droplets are released into the blood circulation and form embolisms, mainly in lung and brain. However, the potential mechanisms involved remain to be clarified. In this study, the mechanism of brain injury following FES and the protective effects of urinary trypsin inhibitor (UTI)-a serine protease inhibitor-were investigated. Read More

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http://journals.sagepub.com/doi/10.1177/0963689718814766
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http://dx.doi.org/10.1177/0963689718814766DOI Listing
November 2018
8 Reads

DRG-Derived Neural Progenitors Differentiate into Functional Enteric Neurons Following Transplantation in the Postnatal Colon.

Cell Transplant 2019 Feb 15;28(2):157-169. Epub 2018 Nov 15.

1 Children's Hospital Affiliated and Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, China.

Cell therapy has great promise for treating gastrointestinal motility disorders caused by intestinal nervous system (ENS) diseases. However, appropriate sources, other than enteric neural stem cells and human embryonic stem cells, are seldom reported. Here, we show that neural progenitors derived from the dorsal root ganglion (DRG) of EGFP mice survived, differentiated into enteric neurons and glia cells, migrated widely from the site of injection, and established neuron-muscle connections following transplantation into the distal colon of postnatal mice. Read More

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http://dx.doi.org/10.1177/0963689718811061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362519PMC
February 2019
8 Reads

White Matter Injury in Early Brain Injury after Subarachnoid Hemorrhage.

Cell Transplant 2019 Jan 16;28(1):26-35. Epub 2018 Nov 16.

1 Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Subarachnoid hemorrhage (SAH) is a major cause of high morbidity, disability, and mortality in the field of neurovascular disease. Most previous SAH studies have focused on improving cerebral blood flow, reducing cerebral vasospasm, reducing neuronal calcium overload, and other treatments. While these studies showed exciting findings in basic science, therapeutic strategies based on the findings have not significantly improved neurological outcomes in patients with SAH. Read More

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http://dx.doi.org/10.1177/0963689718812054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322133PMC
January 2019
13 Reads

Historical Review: Opiate Addiction and Opioid Receptors.

Authors:
Shaocheng Wang

Cell Transplant 2018 Nov 13:963689718811060. Epub 2018 Nov 13.

1 Tsaotun Psychiatric Center, Ministry of Health and Welfare, Taiwan.

Substance use disorders (SUDs), defined as a collection of symptoms including tolerance and withdrawal, are chronic illnesses characterized by relapse and remission. In the United States, billions of dollars have been lost due to SUDs. In the past 30 years, effective medications and behavioral interventions have played a major role in preventing relapse and facilitating longer periods of abstinence. Read More

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http://dx.doi.org/10.1177/0963689718811060DOI Listing
November 2018
16 Reads

Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation.

Cell Transplant 2019 Feb 13;28(2):176-184. Epub 2018 Nov 13.

1 Nuffield Department of Surgical Sciences, University of Oxford, UK.

Although human islet transplantation has been established as valid and safe treatment for patients with type 1 diabetes, the utilization rates of human pancreases for clinical islet transplantation are still limited and substantially determined by the quality and composition of collagenase blends. While function and integrity of collagenase has been extensively investigated, information is still lacking about the most suitable supplementary neutral proteases. The present study compared islet isolation outcome after pancreas digestion by means of collagenase used alone or supplemented with either neutral protease (NP), clostripain (CP), or both proteases. Read More

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http://dx.doi.org/10.1177/0963689718811614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362525PMC
February 2019
7 Reads

Early and Late Protective Effect of Bone Marrow Mononuclear Cell Transplantation on Radiation-Induced Vascular Dysfunction and Skin Lesions.

Cell Transplant 2019 Jan 9;28(1):116-128. Epub 2018 Nov 9.

1 Institute for Radiological Protection and Nuclear Safety (IRSN), PSE-SANTE, Fontenay aux Roses, France.

Skin lesions caused by accidental exposure to radiation or by radiotherapy are a major clinical challenge. We evaluated the effect of bone marrow mononuclear cells (BMMNC) on collagen remodeling and vascular function in radiation-induced skin lesions in the acute and late phases in mice. We studied the effect of BMMNC transplantation in a mouse model of cutaneous radiation injury combining local skin gamma-irradiation and biopsy punch wound. Read More

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http://dx.doi.org/10.1177/0963689718810327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322140PMC
January 2019
3 Reads

A New Approach to Cerebral Palsy Treatment: Discussion of the Effective Components of Umbilical Cord Blood and its Mechanisms of Action.

Cell Transplant 2018 Nov 1:963689718809658. Epub 2018 Nov 1.

1 Stem Cell Clinical Research Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China.

Cerebral palsy (CP) includes a group of persistent non-progressive disorders affecting movement, muscle tone, and/or posture. The total economic loss during the life-span of an individual with CP places a heavy financial burden on such patients and their families worldwide; however, a complete cure is still lacking. Umbilical cord blood (UCB)-based interventions are emerging as a scientifically plausible treatment and possible cure for CP. Read More

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http://dx.doi.org/10.1177/0963689718809658DOI Listing
November 2018
3 Reads
3.570 Impact Factor

Stem Cells from Human Exfoliated Deciduous Teeth (SHED) Differentiate in vivo and Promote Facial Nerve Regeneration.

Cell Transplant 2019 Jan 31;28(1):55-64. Epub 2018 Oct 31.

1 Department of Ophthalmology and Otolaryngology, University of Sao Paulo, School of Medicine, Brazil.

Post-traumatic lesions with transection of the facial nerve present limited functional outcome even after repair by gold-standard microsurgical techniques. Stem cell engraftment combined with surgical repair has been reported as a beneficial alternative. However, the best association between the source of stem cell and the nature of conduit, as well as the long-term postoperative cell viability are still matters of debate. Read More

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http://dx.doi.org/10.1177/0963689718809090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322138PMC
January 2019
1 Read

Epigenetic and Transcriptome Profiling Identifies a Population of Visceral Adipose-Derived Progenitor Cells with the Potential to Differentiate into an Endocrine Pancreatic Lineage.

Cell Transplant 2019 Jan 30;28(1):89-104. Epub 2018 Oct 30.

1 NHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.

Type 1 diabetes (T1D) is characterized by the loss of insulin-producing β-cells in the pancreas. T1D can be treated using cadaveric islet transplantation, but this therapy is severely limited by a lack of pancreas donors. To develop an alternative cell source for transplantation therapy, we carried out the epigenetic characterization in nine different adult mouse tissues and identified visceral adipose-derived progenitors as a candidate cell population. Read More

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http://journals.sagepub.com/doi/10.1177/0963689718808472
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http://dx.doi.org/10.1177/0963689718808472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322142PMC
January 2019
12 Reads

Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury.

Cell Transplant 2019 Jan 28;28(1):47-54. Epub 2018 Oct 28.

1 Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), São Paulo, Brazil.

Crush injuries in peripheral nerves are frequent and induce long-term disability with motor and sensory deficits. Due to axonal and myelin sheath disruptions, strategies for optimized axonal regeneration are needed. Multipotent mesenchymal stromal cells (MSC) are promising because of their anti-inflammatory properties and secretion of neurotrophins. Read More

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http://dx.doi.org/10.1177/0963689718809045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322136PMC
January 2019
3 Reads
3.570 Impact Factor

In Vitro Long-Term Expansion and High Osteogenic Potential of Periodontal Ligament Stem Cells: More Than a Mirage.

Cell Transplant 2019 Jan 28;28(1):129-139. Epub 2018 Oct 28.

2 Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy.

The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has been reached as to what is the ideal protocol. The aim of the present study was to determine the optimal medium formulation for long-term expansion and stemness maintenance of PDLSCs, in order to obtain a sufficient number of cells for therapeutic approaches. Read More

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http://dx.doi.org/10.1177/0963689718807680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322134PMC
January 2019
4 Reads

The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review.

Cell Transplant 2019 Jan 26;28(1):36-46. Epub 2018 Oct 26.

1 Department of Spine Surgery, Affiliated Wenling Hospital of Wenzhou Medical University, China.

Spinal cord injury (SCI) is a devastating disease, with a high rate of disability. In this meta-analysis, we aimed to comprehensively assess the efficacy and safety of mesenchymal stem cells (MSCs) in treating clinical SCI patients. We systematically searched the PUBMED, EMBASE, Chinese Biomedical (CBM), Web of Science and Cochrane databases using the strategy of combination of free-text words and MeSH terms. Read More

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http://dx.doi.org/10.1177/0963689718808471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322141PMC
January 2019
2 Reads

Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets.

Cell Transplant 2018 Dec 26;27(12):1763-1777. Epub 2018 Oct 26.

1 Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Non-coding RNAs (ncRNAs) are a class of functional RNAs that regulate gene expression in a post-transcriptional manner. NcRNAs include microRNAs, long non-coding RNAs and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes, including cerebral ischemic injury, neurodegeneration, neural development, and plasticity. Read More

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http://dx.doi.org/10.1177/0963689718806818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300774PMC
December 2018
13 Reads

The Healing Effects of Conditioned Medium Derived from Mesenchymal Stem Cells on Radiation-Induced Skin Wounds in Rats.

Cell Transplant 2019 Jan 23;28(1):105-115. Epub 2018 Oct 23.

1 Department of Orthopedics, China-Japan Union of Jilin University, Changchun, Jilin, China.

Radioactive dermatitis is caused by the exposure of skin and mucous membranes to radiation fields. The pathogenesis of radioactive dermatitis is complex and difficult to cure. Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) may serve as a promising candidate for the therapy of cutaneous wounds. Read More

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http://dx.doi.org/10.1177/0963689718807410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322144PMC
January 2019
2 Reads

Apolipoprotein E Affects In Vitro Axonal Growth and Regeneration via the MAPK Signaling Pathway.

Cell Transplant 2018 Oct 23:963689718808736. Epub 2018 Oct 23.

2 Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Following central nervous system injury in mammals, failed axonal regeneration is closely related to dysneuria. Previous studies have shown that the obvious effects of apolipoprotein E (ApoE) on traumatic brain injury (TBI) were associated with an axonal mechanism. However, little information on the actions of ApoE and its isoforms on axonal regeneration following TBI was provided. Read More

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http://dx.doi.org/10.1177/0963689718808736DOI Listing
October 2018
12 Reads

Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research.

Cell Transplant 2018 Dec 22;27(12):1723-1730. Epub 2018 Oct 22.

2 Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. Read More

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http://dx.doi.org/10.1177/0963689718806846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300779PMC
December 2018
3 Reads