231,106 results match your criteria Cell Stress & Chaperones [Journal]


Developmental programs interact with ABA to coordinate root suberization in Arabidopsis.

Plant J 2020 Jul 9. Epub 2020 Jul 9.

College of Horticulture & College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

Suberin lamellae, which provide a hydrophobic protective barrier against biotic and abiotic stresses, are widely deposited in various cell types during plant development and in response to stress. However, it remains unclear how developmental programs interact with stress responses to direct the precise spatiotemporal pattern of suberin deposition. In this study, we found that SHORT-ROOT (SHR), together with its downstream factor MYB36, guided suberization specifically in the root endodermis. Read More

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http://dx.doi.org/10.1111/tpj.14920DOI Listing

Effect of rapamycin on repeated immobilization stress-induced immune alterations in the rat spleen.

J Neuroimmunol 2020 Jun 25;346:577309. Epub 2020 Jun 25.

Institute of Experimental Endocrinology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address:

Chronic stress modulates immune system functions via neuroendocrine pathways. Rapamycin inhibits activity of immune cells through the mTOR signaling pathway. We investigated the effect of rapamycin (15 mg/kg, 3-times/week) on neuroimmune-endocrine system in the spleen of rats exposed to 42 cycles of 2-h immobilization. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577309DOI Listing

Dimethyl fumarate protects cardiomyocytes against oxygen-glucose deprivation/reperfusion (OGD/R)-induced inflammatory response and damages via inhibition of Egr-1.

Int Immunopharmacol 2020 Jul 6;86:106733. Epub 2020 Jul 6.

Department of Cardiovascular Surgery, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450000, China.

Acute myocardial infarction (AMI) is associated with high rates of morbidity and mortality. Atherosclerosis is among the leading causes of AMI. The rupture or erosion of atherosclerotic plaques can obstruct coronary arteries, thereby leading to an acute inflammatory reaction to ischemic injury and cardiomyocyte apoptosis. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106733DOI Listing

DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation.

Int Immunopharmacol 2020 Jul 6;86:106729. Epub 2020 Jul 6.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:

Oxidative stress and neuroinflammation have been deeply associated with Alzheimer's disease. DL0410 is a novel acetylcholinesterase inhibitor with potential anti-oxidative effects in AD-related animal models, while the specific mechanism has not been fully clarified. In this study, DL0410 was predicted to be related to the modification of cell apoptosis, oxidation-reduction process, inflammatory response and ERK1/ERK2 cascade by in silico target fishing and GO enrichment analysis. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106729DOI Listing

Cell death associated release of volatile organic sulphur compounds with antioxidant properties in chemical-challenged tobacco BY-2 suspension cultured cells.

J Plant Physiol 2020 Jul 2;251:153223. Epub 2020 Jul 2.

Wageningen University & Research, Horticulture and Product Physiology Group, Droevendaalsesteeg 1, P.O. Box 630, 6700AP, Wageningen, the Netherlands; Wageningen Food and Biobased Research, Bornse Weilanden 9, P.O. Box 17, 6700 AA Wageningen, the Netherlands. Electronic address:

The production of volatile organic compounds (VOCs) during programmed cell death (PCD) is still insufficiently studied and their implication in the process is not well understood. The present study demonstrates that the release of VOSCs with presumed antioxidant capacity (methanethiol, dimethylsulfide and dimethyldisulfide) accompanies the cell death in chemical-stressed tobacco BY-2 suspension cultured cells. The cells were exposed to cell death inducers of biotic nature mastoparan (MP, wasp venom) and camptothecin (CPT, alkaloid), and to the abiotic stress agent CdSO. Read More

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http://dx.doi.org/10.1016/j.jplph.2020.153223DOI Listing

Ecological damage of submerged macrophytes by fresh cyanobacteria (FC) and cyanobacterial decomposition solution (CDS).

J Hazard Mater 2020 Jul 2;401:123372. Epub 2020 Jul 2.

Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, China. Electronic address:

To investigate the deleterious ecological effects of cyanobacteria on submerged macrophytes, this study investigated the effects of different concentrations of fresh cyanobacteria (FC) and cyanobacteria decomposition solution (CDS) on an experimental group of submerged macrophytes (Vallisneria natans (Lour.) Hara and Myriophyllum verticillatum Linn.). Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123372DOI Listing

Phosphate starvation causes different stress responses in the lipid metabolism of tomato leaves and roots.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 6:158763. Epub 2020 Jul 6.

Institute of Bio- and Geosciences (IBG-2: Plant Science), Forschungszentrum Jülich, Wilhelm-Johnen-Straße, D-52428 Jülich, Germany.

Plants have evolved various acclimation responses to cope with phosphate depletion, including several changes in lipid metabolism. Thereby membrane phospholipids are dephosphorylated and can be used as an internal phosphate source, while galactolipids are incorporated into the membrane to maintain membrane functionality. Still little is known about the lipidomic and transcriptomic response of plants other than Arabidopsis thaliana upon phosphate starvation. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158763DOI Listing

Combined transcriptomics and proteomics to identify differential proteins involved in the immune response to the parasite Schistosoma japonicum in snail hosts pre-infected with Exorchis sp.

Acta Trop 2020 Jul 6:105623. Epub 2020 Jul 6.

State Key laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian, China; Cancer Research Center of Xiamen University, Xiamen, Fujian, P. R. China; Parasitology Research Laboratory, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. Electronic address:

Oncomelania hupensis is the obligate intermediate host of Schistosoma japonicum, and it also serves as the first intermediate host for Exorchis sp., which uses Parasilurus asoyus as its definitive host rather than humans. In previous studies, Tang et al. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105623DOI Listing

CsSWEET1a and CsSWEET17 Mediate Growth and Freezing Tolerance by Promoting Sugar Transport across the Plasma Membrane.

Plant Cell Physiol 2020 Jul 9. Epub 2020 Jul 9.

National Center for Tea Plant Improvement, Tea Research Institute, Chinese Academy of Agricultural Sciences; Key Laboratory of Tea Biology and Resources Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, China.

Sugars will eventually be exported transporters (SWEETs) are important in plant biological processes. Expression levels of CsSWEET1a and CsSWEET17 are induced by cold acclimation (CA) and cold stress in Camellia sinensis. Here, we found that CsSWEET17 was alternatively spliced, and its exclusion (Ex) transcript was associated with CA process. Read More

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http://dx.doi.org/10.1093/pcp/pcaa091DOI Listing

Development of depression in patients with oral cavity cancer: a systematic review.

Acta Otolaryngol 2020 Jul 9:1-6. Epub 2020 Jul 9.

Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: The incidence of oral cancer is approximately 300,000 patients annually. A cancer diagnosis and treatment affect both physical and mental issues.

Objectives: The aim of this systematic review was to examine the development of depression in patients who have been treated for oral squamous cell carcinoma (OSCC). Read More

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http://dx.doi.org/10.1080/00016489.2020.1778785DOI Listing

Maize lateral root developmental plasticity induced by mild water stress. II: Genotype-specific spatio-temporal effects on determinate development.

Plant Cell Environ 2020 Jul 9. Epub 2020 Jul 9.

Division of Plant Sciences, University of Missouri, Columbia, Missouri, USA.

Maize lateral roots exhibit determinate growth, whereby the meristem is genetically programmed to stop producing new cells. To explore whether lateral root determinacy is modified under water deficits, we studied two maize genotypes (B73 and FR697) with divergent responses of lateral root growth to mild water stress using an experimental system that provided near-stable water potential environments throughout lateral root development. First-order laterals of the primary root system of FR697 exhibited delayed determinacy when grown at a water potential of -0. Read More

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http://dx.doi.org/10.1111/pce.13840DOI Listing

Alpha2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome.

Clin Sci (Lond) 2020 Jul 9. Epub 2020 Jul 9.

Peking University Third Hospital, Beijing, China.

Acute respiratory distress syndrome (ARDS) is a severe condition with high morbidity and mortality and few interventions. The role of sympathetic stress in the pathogenesis of ARDS has attracted recent research attention. Blockade of alpha-2- or alpha2A-adrenoceptor (α2A-AR) has been shown to attenuate lung injury induced by lipopolysaccharide in rats. Read More

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http://dx.doi.org/10.1042/CS20200586DOI Listing

Prospects for the accelerated improvement of the resilient crop quinoa.

J Exp Bot 2020 Jun 18. Epub 2020 Jun 18.

NovoCrops Centre, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark.

Crops tolerant to drought and salt stress may be developed by two approaches. First, major crops may be improved by introducing genes from tolerant plants. For example, many major crops have wild relatives that are more tolerant to drought and high salinity than the cultivated crops, and, once deciphered, the underlying resilience mechanisms could be genetically manipulated to produce crops with improved tolerance. Read More

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http://dx.doi.org/10.1093/jxb/eraa285DOI Listing

Effects of carbon dioxide pneumoperitoneum on exocrine and endocrine functions, and oxidative state of rat pancreas.

Biotech Histochem 2020 Jul 9:1-6. Epub 2020 Jul 9.

Department of Pediatric Surgery, Faculty of Medicine, Bezmialem Vakif University , Istanbul, Turkey.

We investigated the effects of increased intra-abdominal pressure during laparoscopy on the endocrine and exocrine functions, oxidative stress and histopathology of the pancreas in rats. We established three experimental groups of eight animals. Group 1 was the untreated control. Read More

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http://dx.doi.org/10.1080/10520295.2020.1789224DOI Listing

Endosomal Escape of Polymer-Coated Silica Nanoparticles in Endothelial Cells.

Small 2020 Jul 9:e1907693. Epub 2020 Jul 9.

Regenerative Medicine Program, Houston Methodist Research Institute, Houston, TX, 77030, USA.

Current investigations into hazardous nanoparticles (i.e., nanotoxicology) aim to understand the working mechanisms that drive toxicity. Read More

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http://dx.doi.org/10.1002/smll.201907693DOI Listing

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates.

Acta Neuropathol 2020 Jul 8. Epub 2020 Jul 8.

Faculty of Medicine, Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.

Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription factor XBP1, a key mediator of the ER stress response, delays disease progression and reduces protein aggregation in various models of neurodegeneration. To identify disease modifier genes that may explain the neuroprotective effects of XBP1 deficiency, we performed gene expression profiling of brain cortex and striatum of these animals and uncovered insulin-like growth factor 2 (Igf2) as the major upregulated gene. Read More

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http://dx.doi.org/10.1007/s00401-020-02183-1DOI Listing

A novel homozygous mutation (p.N958K) of SLC12A3 in Gitelman syndrome is associated with endoplasmic reticulum stress.

J Endocrinol Invest 2020 Jul 8. Epub 2020 Jul 8.

Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.

Purpose: Gitelman syndrome (GS) is an autosomal recessive renal tubular disease that arises as a consequence of mutations in the SLC12A3 gene, which codes for an Na-Cl cotransporter (NCC) in distal renal tubules. This study was designed to explore the mutations associated with GS in an effort to more fully understand the molecular mechanisms governing GS.

Methods: We analyzed SLC12A3 mutations in a pedigree including a 42-year-old male with GS as well as four related family members over three generations using Sanger and next generation sequencing approaches. Read More

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http://dx.doi.org/10.1007/s40618-020-01329-yDOI Listing

Methyl cellosolve-induced renal oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, and oncogenic markers in rats.

Toxicol Rep 2020 23;7:779-787. Epub 2020 Jun 23.

Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.

Methyl cellosolve (MC) is used in production of textile, paints, stains, inks, surface coatings, and anti-icing additive in hydraulic fluids and jet fuel. Consequently, the present study investigated its effect on renal cells, in a time-course study in male Wistar rats. Animals were orally administered 50 mg/kg body weight of MC for a period of 7, 14, and 21 days. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332505PMC

NADPH oxidase 5α promotes the formation of CD271 tumor-initiating cells in oral cancer.

Am J Cancer Res 2020 1;10(6):1710-1727. Epub 2020 Jun 1.

Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong 21 Sassoon Road, Pokfulam, Hong Kong, China.

Oral tongue squamous cell carcinoma (OTSCC) has a distinctive cell sub-population known as tumor-initiating cells (TICs). CD271 is a functional TIC receptor in head and neck cancers. The molecular mechanisms governing CD271 up-regulation remains unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339284PMC

A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis.

Theranostics 2020 1;10(16):7193-7210. Epub 2020 Jun 1.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China 510006.

MicroRNAs are known to influence the development of a variety of cancers. Previous studies revealed that miR-1291 has antiproliferative functions in cancer cells. Carnitine palmitoyltransferase 1C (CPT1C) has a vital role in mitochondrial energy metabolism and modulation of cancer cell proliferation. Read More

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http://dx.doi.org/10.7150/thno.44877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330864PMC

Neurological immunotherapy in the era of COVID-19 - looking for consensus in the literature.

Nat Rev Neurol 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology with Institute of Translational Neurology, University of Muenster, Muenster, Germany.

The coronavirus disease 2019 (COVID-19) pandemic is concerning for patients with neuroimmunological diseases who are receiving immunotherapy. Uncertainty remains about whether immunotherapies increase the risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or increase the risk of severe disease and death upon infection. National and international societies have developed guidelines and statements, but consensus does not exist in several areas. Read More

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http://dx.doi.org/10.1038/s41582-020-0385-8DOI Listing

Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy.

Exp Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Institut des Neurosciences de Montpellier, INSERM U1051, F-34091, Montpellier, France.

Environmental light has deleterious effects on the outer retina in human retinopathies, such as ABCA4-related Stargardt's disease and dry age-related macular degeneration. These effects involve carbonyl and oxidative stress, which contribute to retinal cell death and vision loss. Here, we used an albino Abca4 mouse model, the outer retina of which shows susceptibility to acute photodamage, to test the protective efficacy of a new polyunsaturated fatty acid lipophenol derivative. Read More

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http://dx.doi.org/10.1038/s12276-020-0460-7DOI Listing

Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.

Cell Death Dis 2020 Jul 8;11(7):513. Epub 2020 Jul 8.

Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu Province, 210009, China.

Exosomes are increasingly recognized as vehicles of intercellular communication. However, the role of exosome in maintaining cellular homeostasis under stress conditions remained unclear. Here we show that Rab27a expression was upregulated exclusively in tubular epithelial cells (TECs) during proteinuria nephropathy established by adriamycin (ADR) injection and 5/6 nephrectomy as well as in chronic kidney disease patients, leading to the increased secretion of exosomes carrying albumin. Read More

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http://dx.doi.org/10.1038/s41419-020-2709-4DOI Listing

miR-512-3p Overcomes Resistance to Cisplatin in Retinoblastoma by Promoting Apoptosis Induced by Endoplasmic Reticulum Stress.

Med Sci Monit 2020 Jul 9;26:e923817. Epub 2020 Jul 9.

Department of Ophthalmology, Sino-Singapore Eco-City Hospital of Tianjin Medical University, Sino-Singapore Eco-City, Tianjin, China (mainland).

BACKGROUND Retinoblastoma (RB) seriously endangers the vision and even the life of patients. This study aimed to explore the endoplasmic reticulum stress (ERS) and drug resistance of RB and verify the effect of miR-512-3p as a regulator of XBP-1 shearing mechanism on ERS, proliferation, apoptosis, and autophagy levels of RB cells. MATERIAL AND METHODS Y79, weri-RB1, and HXO-RB44 cells were treated with cisplatin (DDP) gradient concentration to construct DDP-resistant cells. Read More

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http://dx.doi.org/10.12659/MSM.923817DOI Listing

Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in .

G3 (Bethesda) 2020 Jul 8. Epub 2020 Jul 8.

University of Puerto Rico

Antifungal drug discovery and design is very challenging because of the considerable similarities in genetic features and metabolic pathways between fungi and humans. However, cell wall composition represents a notable point of divergence. Therefore, a research strategy was designed to improve our understanding of the mechanisms for maintaining fungal cell wall integrity, and to identify potential targets for new drugs that modulate the underlying protein-protein interactions in This study defines roles for Wsc2p and Wsc3p and their interacting protein partners in the cell wall integrity signaling and cell survival mechanisms that respond to treatments with fluconazole and hydrogen peroxide. Read More

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http://dx.doi.org/10.1534/g3.120.401468DOI Listing

Distinct Modes of Balancing Glomerular Cell Proteostasis in Mucolipidosis Type II and III Prevent Proteinuria.

J Am Soc Nephrol 2020 Jul 8. Epub 2020 Jul 8.

Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Background: The mechanisms balancing proteostasis in glomerular cells are unknown. Mucolipidosis (ML) II and III are rare lysosomal storage disorders associated with mutations of the Golgi-resident GlcNAc-1-phosphotransferase, which generates mannose 6-phosphate residues on lysosomal enzymes. Without this modification, lysosomal enzymes are missorted to the extracellular space, which results in lysosomal dysfunction of many cell types. Read More

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http://dx.doi.org/10.1681/ASN.2019090960DOI Listing

The ageing lung under stress.

Eur Respir Rev 2020 Jun 7;29(156). Epub 2020 Jul 7.

Comprehensive Pneumology Center (CPC), University Hospital of the Ludwig-Maximilians-University (LMU) and Helmholtz Zentrum München, Munich, Germany

Healthy ageing of the lung involves structural changes but also numerous cell-intrinsic and cell-extrinsic alterations. Among them are the age-related decline in central cellular quality control mechanisms such as redox and protein homeostasis. In this review, we would like to provide a conceptual framework of how impaired stress responses in the ageing lung, as exemplified by dysfunctional redox and protein homeostasis, may contribute to onset and progression of COPD and idiopathic pulmonary fibrosis (IPF). Read More

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http://dx.doi.org/10.1183/16000617.0126-2020DOI Listing

Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism.

Genome Res 2020 Jul 8. Epub 2020 Jul 8.

Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Less than half of human zygotes survive to birth, primarily due to aneuploidies of meiotic or mitotic origin. Mitotic errors generate chromosomal mosaicism, defined by multiple cell lineages with distinct chromosome complements. The incidence and impacts of mosaicism in human embryos remain controversial, with most previous studies based on bulk DNA assays or comparisons of multiple biopsies of few embryonic cells. Read More

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http://dx.doi.org/10.1101/gr.262774.120DOI Listing

Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia.

Cancer Discov 2020 Jul 8. Epub 2020 Jul 8.

Centre de Recherche en Cancerologie de Toulouse, Inserm and Universite de Toulouse

Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that the ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine (AraC)-resistant leukemic cells from both AML cell lines and patient samples in vivo and in vitro. CD39 cell surface expression and activity is increased in AML patients upon chemotherapy compared to diagnosis and enrichment in CD39-expressing blasts is a marker of adverse prognosis in the clinics. Read More

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http://dx.doi.org/10.1158/2159-8290.CD-19-1008DOI Listing
July 2020
15.929 Impact Factor

Optimized method for extraction of exosomes from human primary muscle cells.

Skelet Muscle 2020 Jul 8;10(1):20. Epub 2020 Jul 8.

Northern Ireland Center for Stratified/Personalised Medicine, Biomedical Sciences Research Institute, Ulster University, Derry~Londonderry, UK.

Skeletal muscle is increasingly considered an endocrine organ secreting myokines and extracellular vesicles (exosomes and microvesicles), which can affect physiological changes with an impact on different pathological conditions, including regenerative processes, aging, and myopathies. Primary human myoblasts are an essential tool to study the muscle vesicle secretome. Since their differentiation in conditioned media does not induce any signs of cell death or cell stress, artefactual effects from those processes are unlikely. Read More

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http://dx.doi.org/10.1186/s13395-020-00238-1DOI Listing

Transcriptomic and biochemical investigations support the role of rootstock-scion interaction in grapevine berry quality.

BMC Genomics 2020 Jul 8;21(1):468. Epub 2020 Jul 8.

CREA Research Centre for Genomics and Bioinformatics, via San Protaso 302, 29017, Fiorenzuola d'Arda, PC, Italy.

Background: In viticulture, rootstock genotype plays a critical role to improve scion physiology, berry quality and to adapt grapevine (Vitis vinifera L.) to different environmental conditions. This study aimed at investigating the effect of two different rootstocks (1103 Paulsen - P - and Mgt 101-14 - M) in comparison with not grafted plants - NGC - on transcriptome (RNA-seq and small RNA-seq) and chemical composition of berry skin in Pinot noir, and exploring the influence of rootstock-scion interaction on grape quality. Read More

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http://dx.doi.org/10.1186/s12864-020-06795-5DOI Listing

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes.

Cell Commun Signal 2020 Jul 8;18(1):105. Epub 2020 Jul 8.

Division of Nephrology, Department of Medicine, The Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1003, New York, NY, 10029, USA.

Background: In the setting of diabetes mellitus, mitochondrial dysfunction and oxidative stress are important pathogenic mechanisms causing end organ damage, including diabetic kidney disease (DKD), but mechanistic understanding at a cellular level remains obscure. In mouse models of DKD, glomerular endothelial cell (GEC) dysfunction precedes albuminuria and contributes to neighboring podocyte dysfunction, implicating GECs in breakdown of the glomerular filtration barrier. In the following studies we wished to explore the cellular mechanisms by which GECs become dysfunctional in the diabetic milieu, and the impact to neighboring podocytes. Read More

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http://dx.doi.org/10.1186/s12964-020-00605-xDOI Listing

Periplogenin Activates ROS-ER Stress Pathway to Trigger Apoptosis via BIP-eIF2α-CHOP and IRE1α-ASK1-JNK Signaling Routes.

Anticancer Agents Med Chem 2020 Jul 7. Epub 2020 Jul 7.

School of Life Sciences, Shanxi University, Taiyuan, Shanxi. China.

Background: Periplogenin (PPG), a natural compound isolated from traditional Chinese herb Cortex Periplocae, has been reported to possess anti-inflammatory and anti-cancer properties.

Objective: The present study aims to investigate the antitumor effects of PPG and the underlying mechanism in human colorectal cancer cells.

Methods: The inhibition of cell growth in vitro was assessed by MTT assay. Read More

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http://dx.doi.org/10.2174/1871520620666200708104559DOI Listing

LIPID PEROXIDATION IN ATHEROSCLEROTIC CARDIOVASCULAR DISEASES.

Antioxid Redox Signal 2020 Jul 8. Epub 2020 Jul 8.

Centro Cardiologico Monzino IRCCS, 18607, via Parea 4, Milano, Italy, 20138;

Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and is an ever-growing global burden that has a considerable socio-economic impact on society. ACVDs encompass diverse pathologies such as coronary artery disease and heart failure among others. Recent Advances: It is known that oxidative stress plays a relevant role in ACVDs and some of its effects are mediated by lipid oxidation. Read More

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http://dx.doi.org/10.1089/ars.2019.7955DOI Listing

Melatonin Regulatory Mechanisms and Phylogenetic Analyses of Melatonin Biosynthesis Related Genes Extracted from Peanut under Salinity Stress.

Plants (Basel) 2020 Jul 6;9(7). Epub 2020 Jul 6.

Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt.

Melatonin improves the tolerance of plants to various environmental stresses by protecting plant cells against oxidative stress damage. The objective of the current study was to determine whether exogenous melatonin (MT) treatments could help protecting peanut () seedlings against salinity stress. This was achieved by investigating enzymatic and non-enzymatic antioxidant systems and the expression of melatonin biosynthesis related genes in response to salinity stress with or without exogenous MT. Read More

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http://dx.doi.org/10.3390/plants9070854DOI Listing

The Premature Senescence in Breast Cancer Treatment Strategy.

Cancers (Basel) 2020 Jul 6;12(7). Epub 2020 Jul 6.

Department of Drug Biotechnology and Bioinformatics, National Medicines Institute, 30/34 Chełmska St, 00-725 Warszawa, Poland.

Cellular senescence is a permanent blockade of cell proliferation. In response to therapy-induced stress, cancer cells undergo apoptosis or premature senescence. In apoptosis-resistant cancer cells or at lower doses of anticancer drugs, therapy-induced stress leads to premature senescence. Read More

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http://dx.doi.org/10.3390/cancers12071815DOI Listing

The Nucleolus and PARP1 in Cancer Biology.

Cancers (Basel) 2020 Jul 6;12(7). Epub 2020 Jul 6.

Molecular Toxicology Group, Department of Biology, 78457 Konstanz, Germany.

The nucleolus has been known for a long time to fulfill crucial functions in ribosome biogenesis, of which cancer cells can become addicted to in order to produce sufficient amounts of proteins for cell proliferation. Recently, the nucleolus has emerged as a central regulatory hub in many other cancer-relevant processes, including stress sensing, DNA damage response, cell cycle control, and proteostasis. This fostered the idea that nucleolar processes can be exploited in cancer therapy. Read More

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http://dx.doi.org/10.3390/cancers12071813DOI Listing

Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM from Beijing, China, in Winter.

Int J Environ Res Public Health 2020 Jul 6;17(13). Epub 2020 Jul 6.

College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China.

Epidemiological studies have corroborated that respiratory diseases, including lung cancer, are related to fine particulate matter (<2.5 μm) (PM) exposure. The toxic responses of PM are greatly influenced by the source of PM. Read More

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http://dx.doi.org/10.3390/ijerph17134874DOI Listing

Placenta-Derived Mesenchymal Stem Cells Restore the Ovary Function in an Ovariectomized Rat Model via an Antioxidant Effect.

Antioxidants (Basel) 2020 Jul 6;9(7). Epub 2020 Jul 6.

Department of Biomedical Science, CHA University, Seongnam 13488, Korea.

Oxidative stress is one of the major etiologies of ovarian dysfunction, including premature ovarian failure (POF). Previous reports have demonstrated the therapeutic effects of human placenta-derived mesenchymal stem cells (PD-MSCs) in an ovariectomized rat model (OVX). However, their therapeutic mechanism in oxidative stress has not been reported. Read More

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http://dx.doi.org/10.3390/antiox9070591DOI Listing

Protective Effects of Bee Venom against Endotoxemia-Related Acute Kidney Injury in Mice.

Biology (Basel) 2020 Jul 6;9(7). Epub 2020 Jul 6.

Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.

Sepsis-associated acute kidney injury (AKI) is a leading cause of death in hospitalized patients worldwide. Despite decades of effort, there is no effective treatment for preventing the serious medical condition. Bee venom has long been used to treat a variety of inflammatory diseases. Read More

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http://dx.doi.org/10.3390/biology9070154DOI Listing

Regulation of Hematopoietic Stem Cell Fate and Malignancy.

Int J Mol Sci 2020 Jul 6;21(13). Epub 2020 Jul 6.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea.

The regulation of hematopoietic stem cell (HSC) fate decision, whether they keep quiescence, self-renew, or differentiate into blood lineage cells, is critical for maintaining the immune system throughout one's lifetime. As HSCs are exposed to age-related stress, they gradually lose their self-renewal and regenerative capacity. Recently, many reports have implicated signaling pathways in the regulation of HSC fate determination and malignancies under aging stress or pathophysiological conditions. Read More

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http://dx.doi.org/10.3390/ijms21134780DOI Listing

Phylloseptin-1 is Leishmanicidal for Amastigotes of Inside Infected Macrophages.

Int J Environ Res Public Health 2020 Jul 6;17(13). Epub 2020 Jul 6.

Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, FM, Universidade de Brasília, Brasília, DF 70910900, Brazil.

Leishmania protozoans are the causal agents of neglected diseases that represent an important public health issue worldwide. The growing occurrence of drug-resistant strains of and severe side effects of available treatments represent an important challenge for the leishmaniases treatment. We have previously reported the leishmanicidal activity of phylloseptin-1 (PSN-1), a peptide found in the skin secretion of (=), against promastigotes. Read More

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http://dx.doi.org/10.3390/ijerph17134856DOI Listing

Shear stress induced by fluid flow produces improvements in tissue-engineered cartilage.

Biofabrication 2020 Jul 8. Epub 2020 Jul 8.

University of California Irvine, Irvine, California, UNITED STATES.

Tissue engineering aims to create implantable biomaterials for the repair and regeneration of damaged tissues. In vitro tissue engineering is generally based on static culture, which limits access to nutrients and lacks mechanical signaling. Using shear stress is controversial because in some cases it can lead to cell death while in others it promotes tissue regeneration. Read More

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http://dx.doi.org/10.1088/1758-5090/aba412DOI Listing

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis.

Aging (Albany NY) 2020 Jul 8;12. Epub 2020 Jul 8.

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited. Studies using skin fibroblasts derived from patients with neurodegenerative disorders demonstrate that cell stress pathways and bioenergetics are altered when compared to healthy individuals. Read More

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http://dx.doi.org/10.18632/aging.103612DOI Listing

Protective effect of the NAC and Sal on Zinc oxide nanoparticles-induced reproductive and development toxicity in pregnant mice.

Food Chem Toxicol 2020 Jul 5:111552. Epub 2020 Jul 5.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China. Electronic address:

The growing use of zinc oxide nanoparticles (ZnO NPs) in various applications has raised many concerns about the potential risks to human health. In this research, the protective effects of cellular oxidative stress inhibitor N-Acetyl-cysteine (NAC) and endoplasmic reticulum (ER) stress inhibitor Salubrinal (Sal) on reproductive toxicity induced by ZnO NPs were investigated. The results showed that application of these two kinds of cell stress inhibitors after oral ingestion of ZnO NPs could prevent the weight loss of pregnant mice; reduce zinc content in the uterus, placenta and fetus; reduce abnormal development of the offspring; and decrease fetal abortion. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111552DOI Listing

Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss.

Food Chem Toxicol 2020 Jul 5:111555. Epub 2020 Jul 5.

Fondazione Policlinico Universitario A, Gemelli IRCCS, Roma, Italia; Department of Head and Neck Surgery, Università Cattolica del Sacro Cuore, Roma, Italia. Electronic address:

Scope: The imbalance of cellular redox status, in conjunction with the activation of inflammatory processes, have been considered common predominant mechanisms of noise-induced hearing loss. The identification of novel natural products as potential therapeutics, targeting oxidative stress and inflammatory pathways, is an emerging field. Here, we focused on the polyphenol caffeic acid (CA), the major representative of hydroxycinnamic acids and phenolic acid, in order to investigate its protective capacity in a model of sensorineural hearing loss induced by noise. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111555DOI Listing

miR-655: a promising regulator with therapeutic potential.

Gene 2020 Jul 5:144932. Epub 2020 Jul 5.

Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, China. Electronic address:

miR-655 is a widely studied non-coding small RNA molecule. miR-655 is down-regulated in at least 15 cancers and up-regulated in acute myeloid leukemia (AML) and breast cancer (BC) cell lines. The expression level of miR-655 is closely related to the prognosis of cancer patients. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144932DOI Listing

Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma.

Cell Rep 2020 Jul;32(1):107872

Center for Genes, Environment, and Health, National Jewish Health, Denver, CO 80206, USA; Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado-AMC, Aurora, CO 80045, USA. Electronic address:

The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus obstruction of the airways. To further investigate this incompletely understood pathobiology, we characterize IL-13 effects on human airway epithelial cell cultures using single-cell RNA sequencing, finding that IL-13 generates a distinctive transcriptional state for each cell type. Specifically, we discover a mucus secretory program induced by IL-13 in all cell types which converts both mucus and defense secretory cells into a metaplastic state with emergent mucin production and secretion, while leading to ER stress and cell death in ciliated cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107872DOI Listing

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.

Cell Rep 2020 Jul;32(1):107865

Université Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France. Electronic address:

Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hippocampal network-on-a-chip, we find that the glucocorticoid receptor agonist dexamethasone (DXM) stimulates the cyclin-dependent kinase 5 (CDK5) to phosphorylate huntingtin (HTT) at serines 1181 and 1201 (S1181/1201), which retards BDNF vesicular transport in cortical axons. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107865DOI Listing

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.

Cell Rep 2020 Jul;32(1):107846

Institute of Molecular Health Sciences, ETH Zurich, Otto-Stern-Weg 7, HPL H36, 8093 Zürich, Switzerland; Medical Faculty, University of Zurich, Zurich, Switzerland. Electronic address:

The ability of pancreatic β-cells to respond to increased demands for insulin during metabolic stress critically depends on proper ribosome homeostasis and function. Excessive and long-lasting stimulation of insulin secretion can elicit endoplasmic reticulum (ER) stress, unfolded protein response, and β-cell apoptosis. Here we show that the diabetes susceptibility gene JAZF1 is a key transcriptional regulator of ribosome biogenesis, global protein, and insulin translation. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107846DOI Listing