202,571 results match your criteria Cell Stress & Chaperones [Journal]


[Immunometabolism and systemic lupus erythematosus].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1120-1124

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease, characterized by production of pathogenic autoantibodies and wide involvement of multiple systems. Damageofimmune tolerance and imbalance of immune homeostasis lead to the production of autoantibodies and the injuries of multiple organs and systems. In recent years, plenty of studies have identified that immunometabolism affects survival status of certain cells, also cell activation, differentiation and effector functions. Read More

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December 2018

Intermittent-Hypoxia-Induced Autophagy Activation Through the ER-Stress-Related PERK/eIF2α/ATF4 Pathway is a Protective Response to Pancreatic β-Cell Apoptosis.

Cell Physiol Biochem 2018 Dec 14;51(6):2955-2971. Epub 2018 Dec 14.

Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin,

Background/aims: Intermittent hypoxia (IH) causes apoptosis in pancreatic β-cells, but the potential mechanisms remain unclear. Endoplasmic reticulum (ER) stress, autophagy, and apoptosis are interlocked in an extensive crosstalk. Thus, this study aimed to investigate the contributions of ER stress and autophagy to IH-induced pancreatic β-cell apoptosis. Read More

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http://dx.doi.org/10.1159/000496047DOI Listing
December 2018

Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis.

Biomed Pharmacother 2018 Dec 15;110:878-886. Epub 2018 Dec 15.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Biochemistry Division and GTMR Unit, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taif University, Taif, Saudi Arabia. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory arthropathy that principally attacks the joints. The present study aimed to explore the potential anti-arthritic effects of caffeic acid and ellagic acid in adjuvant-induced arthritis, compared to celecoxib. The current study also explored the underlying molecular mechanisms e. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.041DOI Listing
December 2018

Protective effects of curcumin against ischemia-reperfusion injury in the liver.

Pharmacol Res 2018 Dec 15. Epub 2018 Dec 15.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.014DOI Listing
December 2018

Endometriosis and cancer.

Free Radic Biol Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Japan.

Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually revealed both genetic and epigenetic backgrounds of the development of endometriosis. In clinical practice, endometriosis has been recognized as a precursor lesion of several types of malignancies and endometriosis-associated carcinoma. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.015DOI Listing
December 2018

Stretch-Activated Piezo1 Channel in Endothelial Cells Relaxes Mouse Intrapulmonary Arteries.

Am J Respir Cell Mol Biol 2018 Dec 18. Epub 2018 Dec 18.

Universite de Bordeaux, 27086, Talence, Aquitaine, France.

In intrapulmonary artery (IPA), endothelial cells (EC) respond to mechanical stimuli by releasing vasoactive factors to set the vascular tone. Piezo1, a stretch-activated calcium permeable channel is a sensor of mechanical stress in EC. The present study was undertaken to investigate the implication of Piezo1 in the endothelium-dependent regulation of IPA tone and its potential involvement in pulmonary hypertension, the main disease of this circulation. Read More

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http://dx.doi.org/10.1165/rcmb.2018-0197OCDOI Listing
December 2018

Ultrastructural patterns of photoacclimation and photodamage to photosynthetic algae cell under environmental stress.

Physiol Plant 2018 Dec 18. Epub 2018 Dec 18.

Department of Bioengineering, Faculty of Biology, Moscow State University, GSP-1 Moscow, 119234, Russia.

In oxygenic phototrophs including unicellular algae, acclimation to and damage by diverse environmental stresses induce profound changes in the ultrastructural organization of the cell. These alterations reflect acclimation of the photosynthetic apparatus to unfavorable conditions (mainly reduction of the chloroplast and its membranal system) and rewiring of the photofixed carbon fluxes in the cell. These changes, eventually pursuing mitigation of the photooxidative damage risk, are manifested by the formation of diverse carbon-rich inclusions. Read More

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http://dx.doi.org/10.1111/ppl.12912DOI Listing
December 2018

A liquid-like organelle at the root of motile ciliopathy.

Elife 2018 Dec 18;7. Epub 2018 Dec 18.

Department of Molecular Biosciences, University of Texas at Austin, Austin, United States.

Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients harbor mutations in the dynein motors that drive cilia beating, the disease also results from mutations in so-called Dynein Axonemal Assembly Factors (DNAAFs) that act in the cytoplasm. The mechanisms of DNAAF action remain poorly defined. Read More

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http://dx.doi.org/10.7554/eLife.38497DOI Listing
December 2018

Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring.

J Am Heart Assoc 2018 Dec;7(24):e010797

1 Dorothy M. Davis Heart and Lung Research Institute College of Medicine The Ohio State University Columbus OH.

Background Particulate matter (particles < 2.5 μm [ PM ]) exposure during the in utero and postnatal developmental periods causes cardiac dysfunction during adulthood. Here, we investigated the potential priming effects of preconception exposure of PM on cardiac function in adult offspring. Read More

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http://dx.doi.org/10.1161/JAHA.118.010797DOI Listing
December 2018

Mid-region parathyroid hormone-related protein is a genome-wide chromatin-binding factor that promotes growth and differentiation of HB2 epithelial cells from the human breast.

Biofactors 2018 Dec 18. Epub 2018 Dec 18.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Palermo, Italy.

Human parathyroid hormone-related protein (PTHrP) is a polyhormone that undergoes proteolytic cleavage producing smaller peptides which exert diversified biological effects. PTHrP signalization is prominently involved in breast development and physiology, but the studies have been focused onto either N-terminal species or full-length protein introduced by gene transfer techniques. Our present work investigates for the first time the effect of the mid-region PTHrP secretory form, that is, the fragment [38-94], on HB2 non-tumoral breast epithelial cells. Read More

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http://dx.doi.org/10.1002/biof.1484DOI Listing
December 2018

Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-κB pathways in acute glaucoma.

Eye (Lond) 2018 Dec 18. Epub 2018 Dec 18.

The First Hospital of Quanzhou Affiliated to Fujian Medical University, No. 250 East Street, Quanzhou, 362000, Fujian Province, China.

Aims Or Purpose: Glaucoma is the leading cause of vision loss and blindness in the world. Elucidating the pathogenesis of glaucoma and developing effective treatment should be the priority. Inflammation and oxidative stress play essential roles in glaucoma pathogeneisis. Read More

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http://dx.doi.org/10.1038/s41433-018-0318-6DOI Listing
December 2018

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.

Acta Pharmacol Sin 2018 Dec 18. Epub 2018 Dec 18.

State Key Laboratory of Drug Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.

Palmitate (PA) exposure induces stress conditions featuring ROS accumulation and upregulation of p62 expression, resulting in autophagic flux blockage and cell apoptosis. Sulfuretin (Sul) is a natural product isolated from Rhus verniciflua Stokes; the cytoprotective effect of Sul on human hepatic L02 cells and mouse primary hepatocytes under PA-induced stress conditions was investigated in this study. Sul induced mitophagy by activation of p-TBK1 and LC3 and produced a concomitant decline in p62 expression. Read More

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http://dx.doi.org/10.1038/s41401-018-0193-5DOI Listing
December 2018

Lipofuscin-mediated photodynamic stress induces adverse changes in nanomechanical properties of retinal pigment epithelium cells.

Sci Rep 2018 Dec 18;8(1):17929. Epub 2018 Dec 18.

Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.

Retinal pigment epithelium (RPE) is an important part of the blood-retina barrier (BRB) that separates the retina from the choroid. Although melanin granules contribute to the mechanical stability of the BRB complex, it is unknown if the age pigment lipofuscin affects mechanical properties of the tissue. To address this issue the effect of sub-lethal photic stress mediated by phagocytized lipofuscin granules, isolated from RPE of human donors, on morphology and mechanical properties of ARPE-19 cells was investigated. Read More

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http://dx.doi.org/10.1038/s41598-018-36322-2DOI Listing
December 2018

HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis.

Sci Rep 2018 Dec 18;8(1):17939. Epub 2018 Dec 18.

Université Paris 13, Sorbonne Paris Cité, Laboratoire 'Hypoxie & Poumon' (EA 2363), F-93017, Bobigny, France.

Endoplasmic Reticulum (ER) stress of alveolar epithelial cells (AECs) is recognized as a key event of cell dysfunction in pulmonary fibrosis (PF). However, the mechanisms leading to AECs ER stress and ensuing unfolded protein response (UPR) pathways in idiopathic PF (IPF) remain unclear. We hypothesized that alveolar hypoxic microenvironment would generate ER stress and AECs apoptosis through the hypoxia-inducible factor-1α (HIF-1α). Read More

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http://dx.doi.org/10.1038/s41598-018-36063-2DOI Listing
December 2018

Transcriptome analysis of the anhydrobiotic cell line Pv11 infers the mechanism of desiccation tolerance and recovery.

Sci Rep 2018 Dec 18;8(1):17941. Epub 2018 Dec 18.

Department of Biosciences and Informatics, Keio University, Yokohama, Kanagawa, 223-8522, Japan.

The larvae of the African midge, Polypedilum vanderplanki, can enter an ametabolic state called anhydrobiosis to overcome fatal desiccation stress. The Pv11 cell line, derived from P. vanderplanki embryo, shows desiccation tolerance when treated with trehalose before desiccation and resumes proliferation after rehydration. Read More

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http://dx.doi.org/10.1038/s41598-018-36124-6DOI Listing
December 2018

On the edge of degradation: Autophagy regulation by RNA decay.

Wiley Interdiscip Rev RNA 2018 Dec 17:e1522. Epub 2018 Dec 17.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.

Cells must dynamically adapt to altered environmental conditions, particularly during times of stress, to ensure their ability to function effectively and survive. The macroautophagy/autophagy pathway is highly conserved across eukaryotic cells and promotes cell survival during stressful conditions. In general, basal autophagy occurs at a low level to sustain cellular homeostasis and metabolism. Read More

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http://dx.doi.org/10.1002/wrna.1522DOI Listing
December 2018

Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity.

Neurosci Bull 2018 Dec 17. Epub 2018 Dec 17.

Laboratory for Translational Pain Medicine, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.

The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely unknown. Our previous study showed that neonatal maternal deprivation (NMD) does not induce visceral hypersensitivity at the age of 6 weeks in rats. The aim of this study was to determine whether NMD followed by adult stress at the age of 6 weeks induces visceral pain in rats and to investigate the roles of adrenergic signaling in visceral pain. Read More

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http://dx.doi.org/10.1007/s12264-018-0318-3DOI Listing
December 2018

Transcriptome-based gene expression profiling of diploid radish (Raphanus sativus L.) and the corresponding autotetraploid.

Mol Biol Rep 2018 Dec 17. Epub 2018 Dec 17.

National Key Laboratory of Crop Genetics and Germplasm Enhancement, Key Laboratory of Horticultural Crop Biology and Genetic Improvement (East China) of MOA, College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

Polyploidy is an important evolutionary factor in most land plant lineages which possess more than two complete sets of chromosomes. Radish (Raphanus sativus L.) is an economically annual/biennial root vegetable crop worldwide. Read More

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http://dx.doi.org/10.1007/s11033-018-4549-1DOI Listing
December 2018

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes.

Arch Toxicol 2018 Dec 17. Epub 2018 Dec 17.

Department of Pharmacy and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Primary human hepatocytes are used in all facets of liver research, from in vitro studies of xenobiotic disposition and toxicity to the clinical management of liver failure. Unfortunately, cellular stress during isolation and cryopreservation causes a highly unpredictable loss of the ability to attach and form cell-matrix and cell-cell interactions. Reasoning that this problem could be mitigated at the post-thawing stage, we applied label-free quantitative global proteomics to analyze differences between attached and non-attached fractions of cryopreserved human hepatocyte batches. Read More

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http://dx.doi.org/10.1007/s00204-018-2375-9DOI Listing
December 2018

[Research progress of the uremic toxin indoxyl sulfate in cardiovascular complication of end-stage renal diseases].

Sheng Li Xue Bao 2018 Dec;70(6):657-662

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

Cardiovascular disease is one of the most common complications and the main cause of death in patients with chronic kidney disease. Uremic toxins are the primary cause of cardiovascular disease in renal insufficiency. In patients with chronic kidney disease, the protein-bound uremic toxins represented by indoxyl sulfate are difficult to be removed by conventional dialysis and are extremely toxic. Read More

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December 2018

Lipidomics reveals insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line.

Mol Omics 2018 Dec 18. Epub 2018 Dec 18.

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, NY 14260, USA.

Engineered nanomaterials have unique properties compared to their bulk counterparts. Copper oxide nanoparticles (CuO NPs) are one example of nanomaterials used in a wide range of consumer products due to their conductivity and biocidal properties. While CuO NPs can induce toxicity in various organisms, their interactions with different organisms and how they affect cellular homeostasis is yet to be fully understood. Read More

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http://dx.doi.org/10.1039/c8mo00162fDOI Listing
December 2018

Rv1288, a Two Domain, Cell Wall Anchored, Nutrient Stress Inducible Carboxyl-Esterase of , Modulates Cell Wall Lipid.

Front Cell Infect Microbiol 2018 3;8:421. Epub 2018 Dec 3.

Department of Biotechnology, Panjab University, Chandigarh, India.

Rv1288, a conserved hypothetical protein of , was recently characterized as two-domain esterase enzyme by study. In the present study, Rv1288 and its domains (Est and Lyt) were cloned individually from into for expression and purification. The purified rRv1288 and rEst proteins exhibited lipolytic activity with medium chain length esters as optimum substrates, while Lyt domain did not show enzymatic activity. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287010PMC
December 2018

Manipulating Eryptosis of Human Red Blood Cells: A Novel Antimalarial Strategy?

Front Cell Infect Microbiol 2018 30;8:419. Epub 2018 Nov 30.

Molecular Parasitology Laboratory, Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.

Malaria is a major global health burden, affecting over 200 million people worldwide. Resistance against all currently available antimalarial drugs is a growing threat, and represents a major and long-standing obstacle to malaria eradication. Like many intracellular pathogens, parasites manipulate host cell signaling pathways, in particular programmed cell death pathways. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284368PMC
November 2018

Allergic Contact Dermatitis, Angioneurotic Edema and Conjunctivitis in a Patient with Autoimmune Thrombocytopenia - A Clinical Case.

Open Access Maced J Med Sci 2018 Nov 21;6(11):2142-2146. Epub 2018 Nov 21.

Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University, Plovdiv, Bulgaria.

Background: Allergic contact dermatitis (ACD) is common in clinical practice, but the aetiology of this disease is quite varied. A leading pathogenetic mechanism is a cell-mediated immunity. The combinations of ACD with other allergic and systemic autoimmune diseases are relatively rare, but these conditions are undoubtedly a professional challenge for practitioners. Read More

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http://dx.doi.org/10.3889/oamjms.2018.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290415PMC
November 2018

Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma.

Open Access Maced J Med Sci 2018 Nov 19;6(11):1982-1985. Epub 2018 Nov 19.

Universitas Sumatera Utara Fakultas Kedokteran, Otorhynolaryngology Head and Neck Surgery Jl. Dr. T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia.

Background: Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.3889/oamjms.2018.355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290411PMC
November 2018

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Front Genet 2018 3;9:558. Epub 2018 Dec 3.

Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

The discovery of the epigenetic regulation of transcription has provided a new source of mechanistic understanding to long lasting effects of chemicals. However, this information is still seldom exploited in a toxicological context and studies of chemical effect after washout remain rare. Here we studied the effects of two nephrocarcinogens on the human proximal tubule cell line RPTEC/TERT1 using high-content mRNA microarrays coupled with miRNA, histone acetylation (HA) and DNA methylation (DM) arrays and metabolomics during a 5-day repeat-dose exposure and 3 days after washout. Read More

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http://dx.doi.org/10.3389/fgene.2018.00558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286959PMC
December 2018

Impact of Multiple Ecological Stressors on a Sub-Arctic Ecosystem: No Interaction Between Extreme Winter Warming Events, Nitrogen Addition and Grazing.

Front Plant Sci 2018 30;9:1787. Epub 2018 Nov 30.

Norwegian Institute for Nature Research, FRAM - High North Research Centre for Climate and the Environment, Tromsø, Norway.

Climate change is one of many ongoing human-induced environmental changes, but few studies consider interactive effects between multiple anthropogenic disturbances. In coastal sub-arctic heathland, we quantified the impact of a factorial design simulating extreme winter warming (WW) events (7 days at 6-7°C) combined with episodic summer nitrogen (+N) depositions (5 kg N ha) on plant winter physiology, plant community composition and ecosystem CO fluxes of an dominated heathland during 3 consecutive years in northern Norway. We expected that the +N would exacerbate any stress effects caused by the WW treatment. Read More

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http://dx.doi.org/10.3389/fpls.2018.01787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284199PMC
November 2018

Unexpected Exacerbation of Neuroinflammatory Response After a Combined Therapy in Old Parkinsonian Mice.

Front Cell Neurosci 2018 30;12:451. Epub 2018 Nov 30.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

The design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson's disease (PD) is an age-related pathology, almost all experimental studies are carried out in young animals. Here, we evaluated the possible neuroprotective effect of the combination of the antioxidant N-acetylcysteine (NAC) and the anti-inflammatory HA-1077 in aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice (C57BL/6 mice, 20 months old), whose individual treatment has been shown to have neuroprotective effects in this Parkinsonism model. Read More

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http://dx.doi.org/10.3389/fncel.2018.00451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284242PMC
November 2018

Sickle Cell Disease: Advances in Treatment.

Authors:
Renée V Gardner

Ochsner J 2018 ;18(4):377-389

Department of Pediatrics, Louisiana State University Health Sciences Center, Children's Hospital of New Orleans, New Orleans, LA.

Background: Sickle cell disease causes significant morbidity and mortality and affects the economic and healthcare status of many countries. Yet historically, the disease has not had commensurate outlays of funds that have been aimed at research and development of drugs and treatment procedures for other diseases.

Methods: This review examines several treatment modalities and new drugs developed since the late 1990s that have been used to improve outcomes for patients with sickle cell disease. Read More

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http://dx.doi.org/10.31486/toj.18.0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292457PMC
January 2018

Memory of ancestral mitochondrial stress.

Nat Cell Biol 2018 Dec 17. Epub 2018 Dec 17.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41556-018-0255-4DOI Listing
December 2018

Escherichia coli can survive stress by noisy growth modulation.

Nat Commun 2018 12 17;9(1):5333. Epub 2018 Dec 17.

Sainsbury Laboratory, University of Cambridge, Cambridge, CB2 1LR, UK.

Gene expression can be noisy, as can the growth of single cells. Such cell-to-cell variation has been implicated in survival strategies for bacterial populations. However, it remains unclear how single cells couple gene expression with growth to implement these strategies. Read More

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http://dx.doi.org/10.1038/s41467-018-07702-zDOI Listing
December 2018

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.

Nat Commun 2018 12 17;9(1):5340. Epub 2018 Dec 17.

Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research, Technologiepark 927, 9052, Zwijnaarde (Ghent), Belgium.

Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear. Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1α is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Importantly, genetic deletion of IRE1α in iNKT cells reduces cytokine production and protects mice from oxazolone colitis. Read More

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http://dx.doi.org/10.1038/s41467-018-07758-xDOI Listing
December 2018

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.

Nat Commun 2018 12 17;9(1):5343. Epub 2018 Dec 17.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

Diverse cellular processes depend on the lysosomal protease system but how cells regulate lysosomal proteolytic capacity is only partly understood. We show here that cells can respond to protease/substrate imbalance in this compartment by de novo expression of multiple lysosomal hydrolases. This response, exemplified here either by loss of asparagine endopeptidase (AEP) or other lysosomal cysteine proteases, or by increased endocytic substrate load, is not dependent on the transcription factor EB (TFEB) but rather is triggered by STAT3 activation downstream of lysosomal oxidative stress. Read More

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http://dx.doi.org/10.1038/s41467-018-07741-6DOI Listing
December 2018

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.

Nat Commun 2018 12 17;9(1):5342. Epub 2018 Dec 17.

University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands.

BAG3 is a multi-domain hub that connects two classes of chaperones, small heat shock proteins (sHSPs) via two isoleucine-proline-valine (IPV) motifs and Hsp70 via a BAG domain. Mutations in either the IPV or BAG domain of BAG3 cause a dominant form of myopathy, characterized by protein aggregation in both skeletal and cardiac muscle tissues. Surprisingly, for both disease mutants, impaired chaperone binding is not sufficient to explain disease phenotypes. Read More

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http://dx.doi.org/10.1038/s41467-018-07718-5DOI Listing
December 2018

Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.

J Biol Chem 2018 Dec 17. Epub 2018 Dec 17.

Pathology, Virginia Commonwealth University, United States.

Inhibition of the proteasome leads to proteotoxic stress which is characterized by the buildup of ubiquitinated proteins that cannot be degraded properly.  The transcription factor Nrf1 (also called NFE2L1) counteracts proteotoxic stress by inducing transcription of proteasome subunit genes resulting in the restoration of proteasome activity.  Further understanding of the Nrf1 pathway is therefore of interest in both neurodegeneration, where proteasome activity could be enhanced, and cancer, where suppression of this pathway could potentiate the cell-killing effect mediated by proteasome inhibitor drugs. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006290DOI Listing
December 2018

Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes.

J Biol Chem 2018 Dec 17. Epub 2018 Dec 17.

University of Gothenburg, Sweden.

β-Adrenergic stimulation of adipose tissue increases mitochondrial density and activity (browning) that are associated with improved whole-body metabolism. Whereas chronically elevated levels of reactive oxygen species (ROS) in adipose tissue contribute to insulin resistance, transient ROS elevation stimulates physiological processes such as adipogenesis. Here, using a combination of biochemical and cell and molecular biology-based approaches, we studied whether ROS or antioxidant treatment affects β3-adrenergic receptor (β3-AR) stimulation-induced adipose tissue browning. Read More

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http://dx.doi.org/10.1074/jbc.RA118.004253DOI Listing
December 2018

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.

Proc Natl Acad Sci U S A 2018 Dec 17. Epub 2018 Dec 17.

Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden;

Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often accompanied by oxidative stress and compromised nitric oxide (NO) signaling, increase the risk of adverse cardiovascular complications and development of fatty liver disease. Here, we investigated the therapeutic effects of dietary nitrate, which is found in high levels in green leafy vegetables, on liver steatosis associated with metabolic syndrome. Read More

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http://dx.doi.org/10.1073/pnas.1809406115DOI Listing
December 2018

TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling.

Proc Natl Acad Sci U S A 2018 Dec 17. Epub 2018 Dec 17.

Stress Cell, Aix Marseille Université, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, F-13009 Marseille, France;

Bone marrow (BM) produces all blood and immune cells deriving from hematopoietic stem cells (HSCs). The decrease of immune cell production during aging is one of the features of immunosenescence. The impact of redox dysregulation in BM aging is still poorly understood. Read More

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http://dx.doi.org/10.1073/pnas.1809980116DOI Listing
December 2018

F-box protein RAE1 regulates the stability of the aluminum-resistance transcription factor STOP1 in .

Proc Natl Acad Sci U S A 2018 Dec 17. Epub 2018 Dec 17.

National Key Laboratory of Plant Molecular Genetics, Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences, 200032 Shanghai, China;

Aluminum (Al) toxicity is a major factor limiting crop production on acid soils, which represent over 30% of the world's arable land. Some plants have evolved mechanisms to detoxify Al. , for example, secretes malate via the AtALMT1 transporter to chelate and detoxify Al. Read More

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http://dx.doi.org/10.1073/pnas.1814426116DOI Listing
December 2018

SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models.

Dis Model Mech 2018 Dec 17. Epub 2018 Dec 17.

Sorbonne Universités, UPMC, Univ Paris 06 UMR_S 1127, INSERM U 1127, CNRS UMR 7225, ICM (Brain and Spine Institute) Pitié-Salpêtrière Hospital, 75013, Paris, France.

Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegerative disease spinocerebellar ataxia type 7 (SCA7) is given by the intranuclear accumulation of mutant, misfolded ataxin-7 (polyQ-ATXN7). Here we show that endogenous ATXN7 is modified by SUMO, thus also suggesting a physiological role for this modification under conditions of proteotoxic stress caused by the accumulation of misfolded ATXN7. Read More

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http://dx.doi.org/10.1242/dmm.036145DOI Listing
December 2018

Coupling of abiotic stresses and phytohormones for the production of lipids and high-value by-products by microalgae: A review.

Bioresour Technol 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address:

Microalgae can produce lipids and high-value by-products under abiotic stress conditions, including nutrient starvation, high light intensity, extreme temperature, high salinity and the presence of heavy metals. However, the growth and development of microalgae and the accumulation of metabolites may be inhibited by adverse stresses. In recent years, phytohormones have emerged as a topic of intense focus in microalgae research. Read More

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http://dx.doi.org/10.1016/j.biortech.2018.12.030DOI Listing
December 2018

Suppression of UV-B stress induced flavonoids by biotic stress: Is there reciprocal crosstalk?

Plant Physiol Biochem 2019 Jan 22;134:53-63. Epub 2018 Jun 22.

Department of Molecular Phytopathology and Biotechnology, Institute of Phytopathology, Christian-Albrechts Universität zu Kiel, 24118, Kiel, Germany.

Plants respond to abiotic UV-B stress with enhanced expression of genes for flavonoid production, especially the key-enzyme chalcone synthase (CHS). Some flavonoids are antioxidative, antimicrobial and/or UV-B protective secondary metabolites. However, when plants are challenged with concomitant biotic stress (simulated e. Read More

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http://dx.doi.org/10.1016/j.plaphy.2018.06.026DOI Listing
January 2019

Juvenile open-angle Glaucoma associated with Leber's hereditary optic neuropathy: a case report and literature review.

BMC Ophthalmol 2018 Dec 17;18(1):323. Epub 2018 Dec 17.

Department of Ophthalmology, Chang-Gung Memorial Hospital, 222 Mai-Chin Rd, Keelung, 204, Taiwan (Republic of China).

Background: Leber's hereditary optic neuropathy (LHON) is a maternally inherited recessive disease rarely complicated with glaucoma. We conducted a clinical and genetic retrospective case series to describe three cases of juvenile open-angle glaucoma (JOAG) and an ND4 m11778G > A mitochondrial DNA (mtDNA) mutation, which is pathognomonic for LHON.

Case Presentation: Patient 1 was a 16-year-old boy diagnosed with bilateral JOAG and high myopia. Read More

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http://dx.doi.org/10.1186/s12886-018-0980-2DOI Listing
December 2018

Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity in female rats.

Hum Exp Toxicol 2018 Dec 17:960327118818246. Epub 2018 Dec 17.

2 Department of Zoology and Entomology, Faculty of Science, Helwan University, Helwan, Egypt.

The aim of this study is to investigate the protective effects of thymoquinone (TQ) and ebselen (Eb) on arsenic (As)-induced renal toxicity in female rats. Sodium arsenite was orally administrated at a dose of 20 mg/kg body weight daily for 28 days, either alone or 1 h before TQ (10 mg/kg) or Eb (5 mg/kg) administration. Renal tissue As concentration and oxidative stress markers, including lipid peroxidation (LPO), nitrite/nitrate, and glutathione (GSH) levels, were determined. Read More

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http://dx.doi.org/10.1177/0960327118818246DOI Listing
December 2018

Regulation of Structure-Specific Endonucleases in Replication Stress.

Genes (Basel) 2018 Dec 14;9(12). Epub 2018 Dec 14.

Program in Molecular & Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.

Replication stress results in various forms of aberrant replication intermediates that need to be resolved for faithful chromosome segregation. Structure-specific endonucleases (SSEs) recognize DNA secondary structures rather than primary sequences and play key roles during DNA repair and replication stress. Holliday junction resolvase MUS81 (methyl methane sulfonate (MMS), and UV-sensitive protein 81) and XPF (xeroderma pigmentosum group F-complementing protein) are a subset of SSEs that resolve aberrant replication structures. Read More

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http://dx.doi.org/10.3390/genes9120634DOI Listing
December 2018

Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation.

Int J Mol Sci 2018 Dec 14;19(12). Epub 2018 Dec 14.

Department of Pharmacology, School of Pharmacy and Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that leads to severe hepatotoxicity at excessive doses. Fucoidan, a sulfated polysaccharide derived from brown seaweeds, possesses a wide range of pharmacological properties. However, the impacts of fucoidan on APAP-induced liver injury have not been sufficiently addressed. Read More

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http://dx.doi.org/10.3390/ijms19124050DOI Listing
December 2018

Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting.

Antioxidants (Basel) 2018 Dec 14;7(12). Epub 2018 Dec 14.

Neonatal Research Group, Health Research Instituto La Fe, 46026 Valencia, Spain.

Aerobic metabolism is highly efficient in providing energy for multicellular organisms. However, even under physiological conditions, an incomplete reduction of oxygen produces reactive oxygen species and, subsequently, oxidative stress. Some of these chemical species are highly reactive free radicals capable of causing functional and structural damage to cell components (protein, lipids, or nucleotides). Read More

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http://dx.doi.org/10.3390/antiox7120193DOI Listing
December 2018

Iron Regulation: Macrophages in Control.

Pharmaceuticals (Basel) 2018 Dec 14;11(4). Epub 2018 Dec 14.

Medical University of Vienna, Center for Pathobiochemistry and Genetics, Vienna 1090, Austria.

Macrophages are sentinel cells of the innate immune system and have important functions in development, tissue homeostasis, and immunity. These phylogenetically ancient cells also developed a variety of mechanisms to control erythropoiesis and the handling of iron. Red pulp macrophages in the spleen, Kupffer cells in the liver, and central nurse macrophages in the bone marrow ensure a coordinated metabolism of iron to support erythropoiesis. Read More

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http://dx.doi.org/10.3390/ph11040137DOI Listing
December 2018

Targeting of senescence and metabolic disorders.

Nihon Rinsho 2016 Sep;74(9):1513-1517

Type 2 diabetes is a major threat to human lifespan, and is caused by tissue dysfunction in insulin sensitive tissues and insulin secreting pancreatic P cells. Prevalence of diabetes is known to increase with age. Tissue dysfunctions in diabetes may be caused in part by a convergence of cellular senescence in adipose tissues and pancreatic p cells. Read More

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September 2016

Treatment of male stress urinary incontinence using autologous adipose-derived regenerative cells: Long-term efficacy and safety.

Int J Urol 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Objectives: To investigate the long-term efficacy and safety of periurethral injection of autologous adipose-derived regenerative cells for the treatment of post-prostatectomy stress urinary incontinence.

Methods: A total of 13 patients with persistent stress urinary incontinence after prostate surgery (radical prostatectomy, 10 patients; holmium laser enucleation of the prostate, three patients) underwent periurethral injection of adipose-derived regenerative cells and were followed up for >4 years. A 24-h pad test was carried out for four consecutive days in each evaluation period, and changes in the mean daily leakage volume during the 4 days from baseline to 60 months after treatment were evaluated. Read More

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http://dx.doi.org/10.1111/iju.13886DOI Listing
December 2018