230,902 results match your criteria Cell Stress & Chaperones[Journal]


Inflammatory Cell Infiltration of Adrenals in COVID-19.

Horm Metab Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Read More

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http://dx.doi.org/10.1055/a-1191-8094DOI Listing

Corticosterone after acute stress prevents the delayed effects on the amygdala.

Neuropsychopharmacology 2020 Jul 6. Epub 2020 Jul 6.

National Centre for Biological Sciences, Bangalore, 560065, India.

Even a single 2-hour episode of immobilization stress is known to trigger anxiety-like behavior and increase spine-density in the basolateral amygdala (BLA) of rats 10 days later. This delayed build-up of morphological and behavioral effects offers a stress-free time window of intervention after acute stress, which we used to test a protective role for glucocorticoids against stress. We observed that post-stress corticosterone, given 1 day after acute stress in drinking water, reversed enhanced anxiety-like behavior 10 days later. Read More

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http://dx.doi.org/10.1038/s41386-020-0758-0DOI Listing

Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition.

Aging (Albany NY) 2020 Jul 6;12. Epub 2020 Jul 6.

Department of Cardiovascular Surgery, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, P.R. China.

Long non-coding RNAs (lncRNAs) have been largely reported to contribute to the development and progression of abdominal aortic aneurysm (AAA), a common vascular degenerative disease. The present study was set out with the aim to investigate the possible role of lncRNA Sox2ot in the development of AAA. In this study, we found that lncRNA Sox2ot and early growth response factor-1 (Egr1) were highly expressed, while microRNA (miR)-145 was poorly expressed in Ang II-induced AAA mice and oxidative stress-provoked vascular smooth muscle cell (VSMC) model. Read More

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http://dx.doi.org/10.18632/aging.103077DOI Listing

Single and repeated low-dose UVB radiation exposures affect the visual system.

J Photochem Photobiol B 2020 Jun 28;209:111941. Epub 2020 Jun 28.

Instituto de Ciências Biológicas (ICB), Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil; Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address:

The visual system is an important biological indicator of effects induced by ultraviolet (UV) radiation. However, research has extensively investigated the effects of high-dose UV radiation in a single exposure, thus, the differential of this work was to investigate the effects of UVB radiation in low doses in single and repeated exposure. Therefore, we investigated the effects of repeated exposure to environmental UVB doses (0. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111941DOI Listing

Foliar application of silicon improves stem strength under low light stress by regulating lignin biosynthesis genes in soybean (Glycine max (L.) Merr.).

J Hazard Mater 2020 Jun 21;401:123256. Epub 2020 Jun 21.

College of Agronomy, Sichuan Agricultural University, 211-Huimin Road, Wenjiang District, Chengdu 611130, PR China; Sichuan Engineering Research Center for Crop Strip Intercropping System, Key Laboratory of Crop Ecophysiology and Farming System in Southwest China (Ministry of Agriculture), Sichuan Agricultural University, Chengdu, PR China. Electronic address:

In order to improve soybean's resistance to lodging, silicon (Si) solutions at concentrations of 0,100, 200,300 mg kg were applied during the seedling stage. The Si accumulation in different parts of the plants, the photosynthetic parameters of leaves and chlorophyll content, the stem bending resistance, the expression of genes of lignin biosynthesis and associated enzyme activity and sap flow rates were measured at early and late growth stages. The potential mechanisms for how Si improve growth and shade tolerance, enhances lodging resistance and improves photosynthesis were analyzed to provide a theoretical basis for the use of Si amendments in agriculture. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123256DOI Listing

Proline rich acidic protein-1 (PRAP1) protects the gastrointestinal epithelium from irradiation-induced apoptosis.

Cell Mol Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA; Emory Microbiome Research Center, Emory University School of Medicine, Atlanta, USA. Electronic address:

Background & Aims: The intestinal epithelium must be resilient to physiochemical stress in order to uphold the physiological barrier separating the systemic compartment from the microbial and antigenic components of the gut lumen. Identifying proteins that mediate protection and enhancing their expression is therefore a clear approach to promote intestinal health. We previously reported that oral ingestion of the probiotic Lactobacillus rhamnosus GG (LGG) not only induced the expression of several recognized cytoprotective factors in the murine colon, but also many genes with no previously described function, including the gene encoding proline rich acidic protein-1 (PRAP1). Read More

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http://dx.doi.org/10.1016/j.jcmgh.2020.06.011DOI Listing

The impact of chronic stress on energy metabolism.

Mol Cell Neurosci 2020 Jul 3:103525. Epub 2020 Jul 3.

Leibniz Institute for Resilience research (LIR), 55128 Mainz, Germany. Electronic address:

The brain is exceptionally demanding in terms of energy metabolism. Approximately 20% of the calories consumed are devoted to our cerebral faculties, with the lion's share provided in the form of glucose. The brain's stringent energy dependency requires a high degree of harmonization between the elements responsible for supplying- and metabolizing energetic substrates. Read More

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http://dx.doi.org/10.1016/j.mcn.2020.103525DOI Listing

Oxidation of bacillithiol by myeloperoxidase-derived oxidants.

Free Radic Biol Med 2020 Jul 3. Epub 2020 Jul 3.

From the Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.

Bacillithiol is a major low-molecular-weight thiol in gram-positive firmicutes including the human pathogen Staphylococcus aureus. Bacillithiol is regarded as an important defence mechanism against oxidants produced by the immune system, especially myeloperoxidase-derived hypochlorous acid (HOCl). However, it is unknown how fast BSH reacts with HOCl and what products are formed in the reaction. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.06.009DOI Listing

Miltefosine inhibits the membrane remodeling caused by phospholipase action by changing membrane physical properties.

Biochim Biophys Acta Biomembr 2020 Jul 3:183407. Epub 2020 Jul 3.

Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address:

Miltefosine (hexadecylphosphocholine or HePC) is an alkylphosphocholine approved for the treatment of visceral and cutaneous Leishmaniasis. HePC exerts its effect by interacting with lipid membranes and affecting membrane-dependent processes. The molecular geometry of HePC suggests that the pharmacological function of HePC is to alter membrane curvature. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183407DOI Listing

Protective role of NRF2 in macrovascular complications of diabetes.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Macrovascular complications develop in over a half of the diabetic individuals, resulting in high morbidity and mortality. This poses a severe threat to public health and a heavy burden to social economy. It is therefore important to develop effective approaches to prevent or slow down the pathogenesis and progression of macrovascular complications of diabetes (MCD). Read More

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http://dx.doi.org/10.1111/jcmm.15583DOI Listing

Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21 and p27.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Cell Biology and Genetics, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into a variety of cell types. Bortezomib, the first approved proteasome inhibitor used for the treatment of multiple myeloma (MM), has been shown to induce osteoblast differentiation, making it beneficial for myeloma bone disease. In the present study, we aimed to investigate the effects and underlying mechanisms of bortezomib on the cell cycle during osteogenic differentiation. Read More

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http://dx.doi.org/10.1111/jcmm.15605DOI Listing

Disruption of Sinonasal Epithelial Nrf2 Enhances Susceptibility to Rhinosinusitis in a Mouse Model.

Laryngoscope 2020 Jul 6. Epub 2020 Jul 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, Maryland, U.S.A.

Objectives/hypothesis: Oxidative stress has been postulated to play an important role in chronic rhinosinusitis. Nrf2 is a transcription factor that is involved in the regulation of multiple antioxidant genes, and its function has been previously shown to be important in sinonasal inflammation. Although the sinonasal implications of whole body Nrf2 has been reported, the function of sinonasal epithelial expression of Nrf2 has not been studied. Read More

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http://dx.doi.org/10.1002/lary.28884DOI Listing

By reducing oxidative stress, naringenin mitigates hyperglycaemia-induced upregulation of hepatic nuclear factor erythroid 2-related factor 2 protein.

J Pharm Pharmacol 2020 Jul 6. Epub 2020 Jul 6.

Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Objectives: Antioxidant and anti-inflammatory properties of naringenin could confer hepatoprotective effects.

Methods: Chang cells in culture media were maintained at 37°C and treated with increased concentrations of glucose (5.5-50 mm) and/or naringenin (25-100 µm), respectively, for 24 h. Read More

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http://dx.doi.org/10.1111/jphp.13319DOI Listing

Anisakis simplex products impair intestinal epithelial barrier function and occludin and zonula occludens-1 localisation in differentiated Caco-2 cells.

PLoS Negl Trop Dis 2020 Jul 6;14(7):e0008462. Epub 2020 Jul 6.

Unit of Immunology, University Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain.

Background: Anisakis spp. are nematode parasites found in a wide range of marine organisms. Human beings may accidentally become infected, showing the symptoms of anisakiasis and allergic responses. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008462DOI Listing

Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.

Am J Physiol Renal Physiol 2020 Jul 6. Epub 2020 Jul 6.

Renal Research Laboratory, Kansas City VA Medical Center.

The ultrafiltrate flow over the major processes and cell body generates fluid flow shear stress (FFSS) on podocytes. Hyperfiltration-associated increase in FFSS can lead to podocyte injury and detachment. Previously, we showed that FFSS-induced upregulation of the COX2-PGE2-EP2 axis in podocytes activates the Akt-GSK3β-β-catenin and MAPK/ERK signaling in response to FFSS. Read More

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http://dx.doi.org/10.1152/ajprenal.00183.2020DOI Listing

Delta-9-tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells.

Physiol Rep 2020 Jul;8(13):e14476

Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

The psychoactive component in cannabis, delta-9-tetrahydrocannabinol, can restrict fetal growth and development. Delta-9-tetrahydrocannabinol has been shown to negatively impact cellular proliferation and target organelles like the mitochondria resulting in reduced cellular respiration. In the placenta, mitochondrial dysfunction leading to oxidative stress prevents proper placental development and function. Read More

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http://dx.doi.org/10.14814/phy2.14476DOI Listing

Augmented oxidative stress and reduced mitochondrial function in ageing goat testis.

Vet Med Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA.

Recently, there is a significant increase in the commercial use of goat products. Nevertheless, there are very few reports on the characterization of redox biomarkers and mitochondrial function in the goat testis. Therefore, in this study we studied the markers of oxidative stress and mitochondrial functions in the goat testis during the process of ageing. Read More

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http://dx.doi.org/10.1002/vms3.296DOI Listing

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

J Cell Biochem 2020 Jul 6. Epub 2020 Jul 6.

Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan.

Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation, reactive oxygen species (ROS)-induced lipid peroxidation results in the formation of reactive aldehydes, foremost of which is 4-hydroxy-2-nonenal (4HNE). 4HNE forms covalent adducts with proteins, negatively impacting cellular protein function. Read More

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http://dx.doi.org/10.1002/jcb.29814DOI Listing

Circ-SPECC1 modulates TGFβ2 and autophagy under oxidative stress by sponging miR-33a to promote hepatocellular carcinoma tumorigenesis.

Cancer Med 2020 Jul 6. Epub 2020 Jul 6.

Institute of Digestive Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Circular RNAs (circRNAs) play vital roles in the pathogenesis and development of multiple cancers, including hepatocellular carcinoma (HCC). Nevertheless, the regulatory mechanisms of circ-SPECC1 in HCC remain poorly understood. In our study, we found that circ-SPECC1 was apparently downregulated in H O -treated HCC cells. Read More

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http://dx.doi.org/10.1002/cam4.3219DOI Listing

Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.

Aging Cell 2020 Jul 6:e13179. Epub 2020 Jul 6.

Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Brain function has been implicated to control the aging process and modulate lifespan. However, continuous efforts remain for the identification of the minimal sufficient brain region and the underlying mechanism for neuronal regulation of longevity. Here, we show that the Drosophila lifespan is modulated by rab27 functioning in a small subset of neurons of the mushroom bodies (MB), a brain structure that shares analogous functions with mammalian hippocampus and hypothalamus. Read More

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http://dx.doi.org/10.1111/acel.13179DOI Listing

Concentrated Growth Factor inhibit UVA-induced photoaging in Human Dermal Fibroblasts via the MAPK/AP-1 pathway.

Biosci Rep 2020 Jul 6. Epub 2020 Jul 6.

Hebei Medical University, Shijiazhuang, China.

Ultraviolet (UV) radiation-induced photoaging is one of the contributors to skin aging. UV light triggers oxidative stress, producing a large number of matrix metalloproteinases and degrading the extracellular matrix in skin cells, thereby causing a series of photoaging symptoms. Concentrated growth factor (CGF) is a leukocyte- and platelet-rich fibrin biomaterial that plays a protective role in the occurrence and development of skin photoaging. Read More

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http://dx.doi.org/10.1042/BSR20193566DOI Listing

[Effect of Guanxin Danshen Formulation on diabetic kidney disease in db/db mice through regulation of Nrf2 pathway].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2595-2600

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100193, China Key Laboratory of New Drug Discovery based on Classic Chinese Medicine Prescription, Chinese Academy of Medical Sciences Beijing 100193, China Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine Beijing 100193, China.

Diabetic kidney disease(DKD) has become a primary cause of end-stage kidney disease, without any effective treatment available. In this study, we assessed the protective effect of Guanxin Danshen Formulation(GXDSF) on diabetic nephropathy in db/db mice. The db/m and db/db mice were randomly divided into 4 groups: control group, model group, metformin group, and GXDSF group. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200418.401DOI Listing

[Screening and verification of proteins of Salvia miltiorrhiza polyphenol oxidase interaction].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2523-2532

State Key Laboratory of Stress Biology in Arid Areas, State and Local Joint Research Center of Traditional Chinese Medicine Fingerprint and Natural Products, College of Chemistry and Pharmacy, Northwest A & F University Yangling 712100, China.

Polyphenol oxidase(PPO) is an important antioxidant enzyme in plants. It has the functions of scavenging active oxygen and synthesizing phenols, lignin, and plant protection factors, and can enhance the plant's resistance to stress and resistance to pests and diseases. Our previous research found that Salvia miltiorrhiza PPO gene can positively regulate salvianolic acid B synthesis. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200329.103DOI Listing

[Progress of research on effect and mechanism of Scutellariae Radix on preventing liver diseases].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2808-2816

Jiangxi Key Laboratory of Natural Drug Research, College of Chemistry and Bioengineering,Yichun University Yichun 336000, China.

Scutellariae Radix is a kind of traditional Chinese medicine, which has the functions of heat-clearing and damp-drying, purging fire and detoxifying, hemostasis and miscarriage prevention. Modern pharmacological studies show that Scutellariae Radix has various effects, such as anti-oxidation, anti-inflammatory, liver protection and antiviral microorganisms. By searching the documents in the past ten years, the author has found that Scutellariae Radix and its active components play an important role in protecting the liver. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200224.403DOI Listing

Autophagy regulation is an effective strategy to improve the prognosis of chemically induced acute liver injury based on experimental studies.

J Cell Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.

Acute liver injury (ALI) induced by chemicals in current experimental studies is characterized by inflammation, oxidative stress and necrosis, which can greatly influence the long-term outcome and lead to liver failure. In liver cells, different autophagy forms envelop cytoplasm components, including proteins, endoplasmic reticulum (ER), mitochondria and lipids, and they effectively participate in breaking down the cargo enclosed inside lysosomes to replenish cellular energy and contents. In general, autophagy serves as a cell survival mechanism in stressful microenvironments, but it also serves as a destructive mechanism that results in cell death in vitro and in vivo. Read More

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http://dx.doi.org/10.1111/jcmm.15565DOI Listing

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance.

EMBO Rep 2020 Jul 6:e201949801. Epub 2020 Jul 6.

Division of Life Science, Department of Cell Biology and Neuroscience, School of Arts and Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Synaptic mitochondria are particularly vulnerable to physiological insults, and defects in synaptic mitochondria are linked to early pathophysiology of Alzheimer's disease (AD). Mitophagy, a cargo-specific autophagy for elimination of dysfunctional mitochondria, constitutes a key quality control mechanism. However, how mitophagy ensures synaptic mitochondrial integrity remains largely unknown. Read More

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http://dx.doi.org/10.15252/embr.201949801DOI Listing

Particulate matter exposure promotes Pseudomonas aeruginosa invasion into airway epithelia by upregulating PAFR via the ROS-mediated PI3K pathway.

Hum Cell 2020 Jul 5. Epub 2020 Jul 5.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University and Shanghai Respiratory Research Institute, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Over exposure to particulate matter (PM) could irritate respiratory tract infection; while, Pseudomonas aeruginosa (P. aeruginosa) is one of the main common pathogens. Our study aims are to define whether PM exposure enhances the invasion of P. Read More

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http://dx.doi.org/10.1007/s13577-020-00378-yDOI Listing

Anti-aging Klotho Protects SH-SY5Y Cells Against Amyloid β1-42 Neurotoxicity: Involvement of Wnt1/pCREB/Nrf2/HO-1 Signaling.

J Mol Neurosci 2020 Jul 5. Epub 2020 Jul 5.

Neurophysiology Research Center, Shahed University, Tehran, Iran.

Alzheimer's disease (AD) is considered a prevalent neurological disorder with a neurodegenerative nature in elderly people. Oxidative stress and neuroinflammation due to amyloid β (Aβ) peptides are strongly involved in AD pathogenesis. Klotho is an anti-aging protein with multiple protective effects that its deficiency is involved in development of age-related disorders. Read More

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http://dx.doi.org/10.1007/s12031-020-01621-9DOI Listing

Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage.

Mol Cell Biochem 2020 Jul 5. Epub 2020 Jul 5.

Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.

P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel which mediates ATP-induced inflammation in macrophages. Transient receptor potential (TRP) receptors are nociceptors in cellular membrane which can perceive the stimuli of environmental irritant. The interaction between TRP channels and P2X7R has been found while the details about inflammation are still unclear. Read More

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http://dx.doi.org/10.1007/s11010-020-03818-3DOI Listing

Melatonin inhibits the endoplasmic reticulum stress‑induced, C/EBP homologous protein‑mediated pathway in acute pancreatitis.

Mol Med Rep 2020 Jun 10. Epub 2020 Jun 10.

Department of Gastroenterology, Dongyang People's Hospital, Dongyang, Zhejiang 322100, P.R. China.

Melatonin, which is mainly secreted by the pineal gland, appears to have anti‑inflammatory activities. Acute pancreatitis (AP) is characterized by inflammation and acinar cell death, and is associated with a high mortality rate. It has been reported that melatonin can alleviate cerulein (Cer) or Cer + lipopolysaccharide (LPS)‑induced inflammatory responses in AR42J rat pancreatic acinar cells (AR42J cells). Read More

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http://dx.doi.org/10.3892/mmr.2020.11219DOI Listing

TSPYL5 activates endoplasmic reticulum stress to inhibit cell proliferation, migration and invasion in colorectal cancer.

Oncol Rep 2020 Aug 9;44(2):449-456. Epub 2020 Jun 9.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Testis‑specific protein Y‑encoded‑like 5 (TSPYL5), a member of the nucleosome assembly protein (NAP) superfamily, functions as a tumor suppressor in ovarian and lung cancer, yet its clinical significance and molecular mechanism in colorectal cancer (CRC) remain unclear. TSPYL5 expression was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database. CRC cell lines HCT116 and HT29 were forced to overexpress TSPYL5 by transfection with pcDNA3. Read More

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http://dx.doi.org/10.3892/or.2020.7639DOI Listing

Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.

Mol Med Rep 2020 Jun 2. Epub 2020 Jun 2.

Zhejiang Provincial Key Lab of Ophthalmology Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.

Oxidative stress-induced injury and apoptosis of human lens epithelial cells (HLECs) are early events in the development of age‑related cataracts (ARCs). Humanin (HN) is a mitochondrial‑related peptide that serves a cytoprotective role in various cell types and animal models. Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmission electron microscopy. Read More

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http://dx.doi.org/10.3892/mmr.2020.11202DOI Listing

Role of endoplasmic reticulum oxidase 1α in H9C2 cardiomyocytes following hypoxia/reoxygenation injury.

Mol Med Rep 2020 Jun 9. Epub 2020 Jun 9.

Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.

Endoplasmic reticulum (ER) oxidase 1α (ERO1α) is a glycosylated flavoenzyme that is located on the luminal side of the ER membrane, which serves an important role in catalyzing the formation of protein disulfide bonds and ER redox homeostasis. However, the role of ERO1α in myocardial hypoxia/reoxygenation (H/R) injury remains largely unknown. In the present study, ERO1α expression levels in H9C2 cardiomyocytes increased following H/R, reaching their highest levels following 3 h of hypoxia and 6 h of reoxygenation. Read More

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http://dx.doi.org/10.3892/mmr.2020.11217DOI Listing

Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonin‑induced osteoblasts.

Mol Med Rep 2020 Jun 15. Epub 2020 Jun 15.

Department of Orthopedics, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Idiopathic scoliosis (IS) is a spinal 3‑dimensional deformity with an unknown cause. Melatonin is secreted by the pineal body and contributes to the occurrence and progression of IS. In our previous preliminary study, it was reported that high concentrations of melatonin can induce osteoblast apoptosis, thus acting as an IS treatment, but the mechanism of action is unknown. Read More

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http://dx.doi.org/10.3892/mmr.2020.11228DOI Listing

Downregulation of folate receptor α contributes to homocysteine‑induced human umbilical vein endothelial cell injury via activation of endoplasmic reticulum stress.

Mol Med Rep 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Elevated plasma homocysteine (Hcy) levels are associated with endothelial dysfunction. Previous studies have indicated the role of endoplasmic reticulum (ER) stress in Hcy‑induced endothelial injury. However, the mechanism of action remains unclear. Read More

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http://dx.doi.org/10.3892/mmr.2020.11204DOI Listing

Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes.

Mol Med Rep 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiology, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China.

Myocardial ischemia‑reperfusion (MI/R) injury is a complex pathological process that occurs when tissues are reperfused following a prolonged period of ischemia. Troxerutin has been reported to have cardioprotective functions. However, the underlying mechanism by which troxerutin protects against MI/R injury has not been fully elucidated. Read More

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http://dx.doi.org/10.3892/mmr.2020.11207DOI Listing

Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling.

Int J Mol Med 2020 Aug 4;46(2):806-816. Epub 2020 Jun 4.

Department of Physiology, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China.

Cisplatin (CDDP) is widely used in clinical settings for the treatment of various cancers. However, ototoxicity is a major side effect of CDDP, and there is an associated risk of irreversible hearing loss. We previously demonstrated that CDDP could induce ototoxicity via activation of the transient receptor potential vanilloid receptor 1 (TRPV1) pathway and subsequent induction of oxidative stress. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4633DOI Listing

miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN.

Mol Med Rep 2020 Jun 1. Epub 2020 Jun 1.

Department of Ophthalmology, Wujiang First People's Hospital, Suzhou, Jiangsu 215200, P.R. China.

Glaucoma is an optic neuropathy that may lead to visual field loss and blindness. Human trabecular meshwork (HTM) cell dysfunction increases intraocular pressure, which leads to glaucoma. microRNAs (miRs) are single‑stranded non‑coding RNAs that regulate cellular processes in HTM cells. Read More

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http://dx.doi.org/10.3892/mmr.2020.11198DOI Listing

Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen‑glucose deprivation by modulating TXNIP.

Int J Mol Med 2020 Aug 11;46(2):889-897. Epub 2020 Jun 11.

Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China.

The thioredoxin interaction protein (TXNIP) has been reported to be closely related to cell oxidative stress, apoptosis and inflammation. TXNIP is involved in the regulation of oxidative stress in lung and renal injury. However, it is unclear as to whether it participates in the protective effects of sevoflurane preconditioning in cardiomyocyte injury caused by oxidative stress in ischemia. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4639DOI Listing

Green Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats.

J Diabetes Res 2020 12;2020:6762709. Epub 2020 Jun 12.

Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Diabetes mellitus (DM) is a chronic endocrine disease characterized by persistent hyperglycemia. Oxidative damage, inflammatory cytokines, and apoptotic cell death play a major role in the induction and progression of male testicular damage. Plant-derived phytochemicals such as green coffee () can possess antidiabetic effects with little toxicity. Read More

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http://dx.doi.org/10.1155/2020/6762709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306074PMC

Heme-Dependent ER Stress Apoptosis: A Mechanism for the Selective Toxicity of the Dihydroartemisinin, NSC735847, in Colorectal Cancer Cells.

Front Oncol 2020 17;10:965. Epub 2020 Jun 17.

Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Colorectal cancer (CRC) is a leading cause of cancer death in the United States. Artemisinin derivatives, including the dihydroartemisinin (DHA) monomers, are widely used as clinical agents for the treatment of malaria. Numerous studies demonstrate that these molecules also display antineoplastic activity with minimal toxicity. Read More

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http://dx.doi.org/10.3389/fonc.2020.00965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313430PMC

CYP1B1 gene: Implications in glaucoma and cancer.

J Cancer 2020 19;11(16):4652-4661. Epub 2020 May 19.

King Abdullah International Medical Research Center (KAIMRC)/ King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), MNGHA, Saudi Arabia.

Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures. Read More

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http://dx.doi.org/10.7150/jca.42669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330686PMC

Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in oleaginous fungus .

Biotechnol Biofuels 2020 1;13:116. Epub 2020 Jul 1.

State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122 Jiangsu People's Republic of China.

Background: Global resource reallocation is an established critical strategy through which organisms deal with environmental stress. The regulation of intracellular lipid storage or utilization is one of the most important strategies for maintaining energy homeostasis and optimizing growth. Oleaginous microorganisms respond to nitrogen deprivation by inducing lipid hyper accumulation; however, the associations between resource allocation and lipid accumulation are poorly understood. Read More

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http://dx.doi.org/10.1186/s13068-020-01757-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328260PMC

Cross-Species Annotation of Expressed Genes and Detection of Different Functional Gene Modules Between 10 Cold- and 10 Hot-Propertied Chinese Herbal Medicines.

Front Genet 2020 18;11:532. Epub 2020 Jun 18.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

According to the traditional Chinese medicine (TCM) system, Chinese herbal medicines (HMs) can be divided into four categories: hot, warm, cold, and cool. A cool nature usually is categorized as a cold nature, and a warm nature is classified as a hot nature. However, the detectable characteristics of the gene expression profile associated with the cold and hot properties have not been studied. Read More

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http://dx.doi.org/10.3389/fgene.2020.00532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314971PMC

Oxidative Stress, Programmed Cell Death and Microcystin Release in in Response to Grazers.

Front Microbiol 2020 17;11:1201. Epub 2020 Jun 17.

Department of Environmental Medicine, Poznan University of Medical Sciences, Poznan´, Poland.

There is increasing evidence that programmed cell death (PCD) in cyanobacteria is triggered by oxidative stress and that it contributes to the survival of the cyanobacterial population such as . At the same time, microcystins (MCs) released during cell lysis have been implicated in colony formation (enabled by the release of polysaccharides) in - a strategy that allows the effect of a stressor, including grazing to be avoided or decreased. This experimental research has explored whether extracts of and (corresponding to 5, 25, 50, and 100 individuals per liter) reveal the effect on the growth, intracellular reactive oxygen species (ROS) content, lipid peroxidation, PCD, MC-LR release, and bound exopolysaccharide (EPS) level in during 7 days of exposure. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311652PMC

Underestimated Survival of in Raw Milk Highlighted by Viability Real-Time PCR and Growth Recovery.

Front Microbiol 2020 17;11:1107. Epub 2020 Jun 17.

National Reference Laboratory for Campylobacter, Department of Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.

Raw milk is a frequent vehicle for transmission of thermophilic , leading to reported outbreaks. Milk is a challenging food matrix for pathogen detection, due to its high protein and lipid content. Limited detection of colony-forming unit (CFU) in raw milk might underestimate the pathogen's infectious potential. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311638PMC

The Importance of Mechanical Forces for Endothelial Cell Biology.

Front Physiol 2020 18;11:684. Epub 2020 Jun 18.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with their luminal and abluminal extracellular environments. These interactions confer physical forces on the endothelium, such as shear stress, stretch and stiffness, to mediate biological responses. These physical forces are often altered during disease, driving abnormal endothelial cell behavior and pathology. Read More

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http://dx.doi.org/10.3389/fphys.2020.00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314997PMC

-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned?

Front Physiol 2020 17;11:577. Epub 2020 Jun 17.

Red Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zürich, Switzerland.

The -methyl-D-aspartate receptor (NMDAR) provides a pathway for glutamate-mediated inter-cellular communication, best known for its role in the brain but with multiple examples of functionality in non-neuronal cells. Data previously published by others and us provided evidence that NMDARs regulate platelet and red blood cell (RBC) production. Here, we summarize what is known about these hematopoietic roles of the NMDAR. Read More

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http://dx.doi.org/10.3389/fphys.2020.00577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311790PMC

Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells.

Int J Med Sci 2020 30;17(10):1375-1384. Epub 2020 May 30.

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Cladribine is a purine nucleoside analog used to treat B-cell chronic lymphocytic leukemia and hairy cell leukemia, also functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. The therapeutic role of cladribine against diffuse large B-cell lymphoma cells (DLBCL) is still undefined. In the present study, we demonstrated that cladribine inhibited cell proliferation and induced G phase arrest in human DLBCL cells. Read More

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http://dx.doi.org/10.7150/ijms.41793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330656PMC

Red cell distribution width as a marker of activity in inflammatory bowel disease: a narrative review.

Ann Gastroenterol 2020 Jul-Aug;33(4):348-354. Epub 2020 May 10.

Gastroenterology and Hepatology Division of the Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital (Marios Katsaros, Olga Giouleme).

Red blood cell distribution width is a parameter measured automatically in every complete blood count that actually reflects the degree of anisocytosis of the red blood cell population. It is a cost-effective tool used in everyday clinical practice along with other parameters to define and narrow the cause of anemia. In a series of pathologic entities, such as cardiovascular diseases, autoimmune diseases, malignancy, chronic renal diseases and chronic respiratory diseases, where inflammation and oxidative stress comprise the major pathophysiologic insults, red cell distribution width behaves as a significant and competent marker able to predict and assess disease activity and severity. Read More

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http://dx.doi.org/10.20524/aog.2020.0486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315702PMC