1,745 results match your criteria Cell Proliferation[Journal]


The lncRNA H19 binding to let-7b promotes hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy.

Cell Prolif 2020 Jul 10:e12856. Epub 2020 Jul 10.

Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Objectives: Glial cell activation contributes to the inflammatory response and occurrence of epilepsy. Our preliminary study demonstrated that the long non-coding RNA, H19, promotes hippocampal glial cell activation during epileptogenesis. However, the precise mechanisms underlying this effect remain unclear. Read More

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http://dx.doi.org/10.1111/cpr.12856DOI Listing

Morroniside attenuates high glucose-induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis.

Cell Prolif 2020 Jul 9:e12866. Epub 2020 Jul 9.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objectives: High glucose (HG)-mediated bone marrow mesenchymal stem cell (BMSC) dysfunction plays a key role in impaired bone formation induced by type 1 diabetes mellitus (T1DM). Morroniside is an iridoid glycoside derived from the Chinese herb Cornus officinalis, and it has abundant biological activities associated with cell metabolism and tissue regeneration. However, the effects and underlying mechanisms of morroniside on HG-induced BMSC dysfunction remain poorly understood. Read More

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http://dx.doi.org/10.1111/cpr.12866DOI Listing

Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis.

Cell Prolif 2020 Jul 1:e12830. Epub 2020 Jul 1.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Objectives: Skin serves as the major interface between the external environment and body which is liable to many kinds of injuries. Mesenchymal stem cell (MSC) therapy has been widely used and became a promising strategy. Pre-treatment with chemical agents, hypoxia or gene modifications can partially protect MSCs against injury, and the pre-treated MSCs show the improved differentiation, homing capacity, survival and paracrine effects regard to attenuating injury. Read More

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http://dx.doi.org/10.1111/cpr.12830DOI Listing

Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.

Cell Prolif 2020 Jun 29:e12869. Epub 2020 Jun 29.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Objectives: Cryptococcus heimaeyensis S20 is found in Antarctica and can produce exopolysaccharides (CHEPS). Here, we explore the anti-tumour effects of CHEPS on non-small cell lung cancer (NSCLC).

Materials And Methods: Cell viability was assessed by CCK8 and colony formation assays. Read More

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http://dx.doi.org/10.1111/cpr.12869DOI Listing

High-efficient generation of VCAM-1 mesenchymal stem cells with multidimensional superiorities in signatures and efficacy on aplastic anaemia mice.

Cell Prolif 2020 Jun 29:e12862. Epub 2020 Jun 29.

State Key Laboratory of Experimental Hematology & National Clinical Research Center for Blood Disease, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Objective: Longitudinal studies have indicated VCAM-1 mesenchymal stem/stromal cells (MSCs) as promising resources in regenerative medicine, yet the abundance in gene expression is far from adequate in the advantaged and "discarded" hUC-MSCs. Thus, high-efficient preparation and systematic dissection of the signatures and biofunctions of the subpopulation is the prerequisite for large-scale clinical applications.

Materials And Methods: We primarily took advantage of a cytokine-based programming strategy for large-scale VCAM-1 hUC-MSC generation (III-MSCs). Read More

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http://dx.doi.org/10.1111/cpr.12862DOI Listing

Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol-induced osteonecrosis of the femoral head.

Cell Prolif 2020 Jun 29:e12871. Epub 2020 Jun 29.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objectives: Osteonecrosis of the femoral head (ONFH), largely caused by alcohol abuse, is a refractory bone disease characterized by the impaired capacity of osteogenic differentiation of bone mesenchymal stem cells (BMSCs), as well as the disordered adipocyte accumulation. Chrysophanic acid (CPA) is a natural anthraquinone which has lipid regulation and bone protection capacity. The aim of this study was to reveal the potential function of CPA and the underlying mechanisms for the alcohol-induced ONFH. Read More

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http://dx.doi.org/10.1111/cpr.12871DOI Listing

Effects of propofol on the development of cancer in humans.

Cell Prolif 2020 Jun 29:e12867. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Cancer is one of most the significant threats to human health worldwide, and the primary method of treating solid tumours is surgery. Propofol, one of the most widely used intravenous anaesthetics in surgery, was found to be involved in many cancer-related pathophysiology processes, mainly including anti-tumour and minor cancer-promoting effects in various types of cancer. An increasing number of studies have identified that propofol plays a role in cancer by regulating the expression of multiple signalling pathways, downstream molecules, microRNAs and long non-coding RNAs. Read More

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http://dx.doi.org/10.1111/cpr.12867DOI Listing

RNA processing genes characterize RNA splicing and further stratify colorectal cancer.

Cell Prolif 2020 Jun 28:e12861. Epub 2020 Jun 28.

State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, P.R. China.

Objectives: Due to the limited evaluation of the prognostic value of RNA processing genes (RPGs), which are regulators of alternative splicing events (ASEs) that have been shown to be associated with tumour progression, this study sought to determine whether colorectal cancer (CRC) could be further stratified based on the expression pattern of RPGs.

Materials And Methods: The gene expression profiles of CRCs were collected from TCGA (training set) and three external validation cohorts, representing 1060 cases totally. Cox regression with least absolute shrinkage and selection operator (LASSO) penalty was used to develop an RNA processing gene index (RPGI) risk score. Read More

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http://dx.doi.org/10.1111/cpr.12861DOI Listing

Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor.

Cell Prolif 2020 Jun 27:e12858. Epub 2020 Jun 27.

The Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology (SIBET), Chinese Academy of Sciences, Suzhou, China.

Objectives: Traditional cancer therapy and regular immunotherapy are ineffective for treating triple-negative breast cancer (TNBC) patients. Recently, chimeric antigen receptor-engineered natural killer cells (CAR NK) have been applied to target several hormone receptors on different cancer cells to improve the efficacy of immunotherapy. Furthermore, epidermal growth factor receptor (EGFR) is a potential therapeutic target for TNBC. Read More

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http://dx.doi.org/10.1111/cpr.12858DOI Listing

Modifying the tumour microenvironment and reverting tumour cells: New strategies for treating malignant tumours.

Cell Prolif 2020 Jun 26:e12865. Epub 2020 Jun 26.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

The tumour microenvironment (TME) plays a pivotal role in tumour fate determination. The TME acts together with the genetic material of tumour cells to determine their initiation, metastasis and drug resistance. Stromal cells in the TME promote the growth and metastasis of tumour cells by secreting soluble molecules or exosomes. Read More

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http://dx.doi.org/10.1111/cpr.12865DOI Listing

Bone mesenchymal stem cells are recruited via CXCL8-CXCR2 and promote EMT through TGF-β signal pathways in oral squamous carcinoma.

Cell Prolif 2020 Jun 26:e12859. Epub 2020 Jun 26.

Department of Oral Pathology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun, China.

Objectives: Bone mesenchymal stem cells (BMSCs) play critical roles in tumour microenvironment. However, molecular mechanisms of how BMSCs to be recruited and effect subsequent tumour progression are poorly understood in oral squamous cell carcinoma (OSCC).

Materials And Methods: The distribution of CXCL8 was detected by immunohistochemical staining in OSCC tissues. Read More

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http://dx.doi.org/10.1111/cpr.12859DOI Listing

Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis.

Cell Prolif 2020 Jun 24:e12857. Epub 2020 Jun 24.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.

Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most mammalian cell types and then released. Exosomes are effective carriers for the intercellular material transfer of material that can influence a series of physiological and pathological processes in recipient cells. Among loaded cargoes, non-coding RNAs (ncRNAs) vary for the exosome-producing cell and its homeostatic state, and characterization of the biogenesis and secretion of exosomal ncRNAs and the functions of these ncRNAs in skeletal muscle myogenesis remain preliminary. Read More

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http://dx.doi.org/10.1111/cpr.12857DOI Listing

The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers.

Cell Prolif 2020 Jun 23:e12860. Epub 2020 Jun 23.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs), which encompasses family members, GDNF, neurturin (NRTN) and persephin (PSPN). ARTN is also referred to as Enovin or Neublastin, and bears structural characteristics of the TGF-β superfamily. ARTN contains a dibasic cleavage site (RXXR) that is predicted to be cleaved by furin to yield a carboxy-terminal 113 amino acid mature form. Read More

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http://dx.doi.org/10.1111/cpr.12860DOI Listing

Overproduced bone marrow neutrophils in collagen-induced arthritis are primed for NETosis: An ignored pathological cell involving inflammatory arthritis.

Cell Prolif 2020 Jun 22:e12824. Epub 2020 Jun 22.

Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Objectives: Bone marrow edema is a universal manifestation of rheumatoid arthritis (RA), and its pathological essence is a bone marrow lesion (BML) formed by various bone marrow (BM) immune cells. Neutrophils play an important role in inflammatory arthritis, but the role and mechanism of neutrophils in BML are not clear.

Materials And Methods: Granulocyte colony-stimulating factor (G-CSF) -/- mice and wild type (WT) C57BL/6 mice were immunized for collagen-induced arthritis (CIA). Read More

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http://dx.doi.org/10.1111/cpr.12824DOI Listing

Metformin protects against mouse oocyte apoptosis defects induced by arecoline.

Cell Prolif 2020 Jun 17:e12809. Epub 2020 Jun 17.

College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao, China.

Objectives: Arecoline is the main bioactive substance extracted from Areca catechu L, which has cell, neural and genetic toxicity. The function of arecoline in reproductive system has not been well explored.

Materials And Methods: To investigate the toxic effects of arecoline on oocyte development, immunofluorescence staining, qPCR, Western blotting, sperm binding assays and in vitro fertilization were performed to evaluate oocyte meiosis competence and embryo development. Read More

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http://dx.doi.org/10.1111/cpr.12809DOI Listing

HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway.

Cell Prolif 2020 Jun 17:e12835. Epub 2020 Jun 17.

Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Objectives: HOXD3 is associated with progression of multiple types of cancer. This study aimed to identify the association of YY1 with HOXD3-ITGA2 axis in the progression of hepatocellular carcinoma.

Materials And Methods: Bioinformatics assay was used to identify the effect of YY1, HOXD3 and ITGA2 expression in HCC tissues. Read More

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http://dx.doi.org/10.1111/cpr.12835DOI Listing
June 2020
3.116 Impact Factor

The up-regulation of NDRG1 by HIF counteracts the cancer-promoting effect of HIF in VHL-deficient clear cell renal cell carcinoma.

Cell Prolif 2020 Jun 14:e12853. Epub 2020 Jun 14.

Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital, Fudan University, Shanghai, China.

Background: Hypoxia-inducible factors (HIFs) are thought to play important roles in the carcinogenesis and progression of VHL-deficient clear cell renal cell carcinoma (ccRCC).

Methods: The roles of HIF-1/2α in VHL-deficient clear cell renal cell carcinoma were evaluated by bioinformatics analysis, immunohistochemistry staining and Kaplan-Meier survival analysis. The downstream genes that counteract the cancer-promoting effect of HIF were analysed by unbiased proteomics and verified by in vitro and in vivo assays. Read More

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http://dx.doi.org/10.1111/cpr.12853DOI Listing

ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma.

Cell Prolif 2020 Jun 14:e12836. Epub 2020 Jun 14.

Research Laboratory of Clinical Virology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Objectives: Integrin beta-like 1 (ITGBL1) is involved in the migration and invasion of several cancers; however, its roles in the development and progression of hepatocellular carcinoma (HCC) remain largely unknown.

Materials And Methods: Immunohistochemistry staining was used to investigate the expression pattern of ITGBL1 and its prognostic values in HCC patients. The transwell, wound-healing assays, xenograft and orthotopic mouse models were employed to determine the effects of ITGBL1 on HCC cell migration and invasion in vitro and in vivo. Read More

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http://dx.doi.org/10.1111/cpr.12836DOI Listing
June 2020
3.116 Impact Factor

A review on methods for diagnosis of breast cancer cells and tissues.

Cell Prolif 2020 Jun 12:e12822. Epub 2020 Jun 12.

Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.

Breast cancer has seriously been threatening physical and mental health of women in the world, and its morbidity and mortality also show clearly upward trend in China over time. Through inquiry, we find that survival rate of patients with early-stage breast cancer is significantly higher than those with middle- and late-stage breast cancer, hence, it is essential to conduct research to quickly diagnose breast cancer. Until now, many methods for diagnosing breast cancer have been developed, mainly based on imaging and molecular biotechnology examination. Read More

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http://dx.doi.org/10.1111/cpr.12822DOI Listing

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis.

Cell Prolif 2020 Jun 12:e12854. Epub 2020 Jun 12.

Institute of Clinical Pharmacology, Key Laboratory of Anti-inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Medical University, Hefei, China.

Macrophages maintain a dynamic balance in physiology. Various known or unknown microenvironmental signals influence the polarization, activation and death of macrophages, which creates an imbalance that leads to disease. Rheumatoid arthritis (RA) is characterized by the massive infiltration of a variety of chronic inflammatory cells in synovia. Read More

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http://dx.doi.org/10.1111/cpr.12854DOI Listing

Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade ≥ A2 promoted the progression of liver cancer by transferring miR-25-3p to inhibit the co-expression of TCF21 and HHIP.

Cell Prolif 2020 Jun 11:e12833. Epub 2020 Jun 11.

Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China.

Objectives: The current study aimed to investigate the mechanism by which exosomes secreted by CHB patients with PNALT and liver inflammation grade (≥A2) affected the development of liver cancer.

Materials And Methods: Gene expression was assessed by RT-PCR, Western blotting and immunohistochemistry. CCK-8, colony formation, transwell, scratch-wound and flow cytometry assays were used to detect cell viability, proliferation, apoptosis and metastasis. Read More

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http://dx.doi.org/10.1111/cpr.12833DOI Listing

Autophagy changes in lung tissues of mice at 30 days after carbon black-metal ion co-exposure.

Cell Prolif 2020 Jun 9:e12813. Epub 2020 Jun 9.

Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.

Objectives: Accumulating studies have investigated the PM2.5-induced pulmonary toxicity, while gaps still remain in understanding its toxic mechanism. Due to its high specific surface area and adsorption capacity similar to nanoparticles, PM2. Read More

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http://dx.doi.org/10.1111/cpr.12813DOI Listing

LncRNA BBOX1-AS1 upregulates HOXC6 expression through miR-361-3p and HuR to drive cervical cancer progression.

Cell Prolif 2020 Jun 9:e12823. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.

Objectives: Over the past years, growing attention has been paid to deciphering the pivotal role of long non-coding RNAs (lncRNAs) in regulating the occurrence and development of human malignancies, cervical cancer (CC) included. Nonetheless, the regulatory role of lncRNA BBOX1 antisense RNA 1 (BBOX1-AS1) has not been explored as yet.

Material And Methods: The expression of BBOX1-AS1 was detected by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Read More

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http://dx.doi.org/10.1111/cpr.12823DOI Listing
June 2020
3.116 Impact Factor

The function and mechanism of circular RNAs in gastrointestinal tumours.

Cell Prolif 2020 Jun 8:e12815. Epub 2020 Jun 8.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Gastrointestinal tumours are tumours that originate in the digestive tract and have extremely high morbidity and mortality. The main categories include: oesophageal, gastric, and colorectal cancers. Circular RNAs are a new class of non-coding RNAs with a covalent closed-loop structure without a 5' cap or a 3' poly A tail, which can encode a small amount of polypeptide. Read More

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http://dx.doi.org/10.1111/cpr.12815DOI Listing

Mechanosensing by Gli1 cells contributes to the orthodontic force-induced bone remodelling.

Cell Prolif 2020 May 23;53(5):e12810. Epub 2020 Apr 23.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Objectives: Gli1 cells have received extensive attention in tissue homeostasis and injury mobilization. The aim of this study was to investigate whether Gli1 cells respond to force and contribute to bone remodelling.

Materials And Methods: We established orthodontic tooth movement (OTM) model to assess the bone response for mechanical force. Read More

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http://dx.doi.org/10.1111/cpr.12810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260067PMC

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells by modulating Wnt/β-catenin signalling pathway via DNA methylation.

Cell Prolif 2020 Jun 28;53(6):e12834. Epub 2020 May 28.

Department of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, China.

Objectives: Advanced glycation end products (AGEs) are considered a cause of diabetic osteoporosis. Although adipose-derived stem cells (ASCs) are widely used in the research of bone regeneration, the mechanisms of the osteogenic differentiation of ASCs from diabetic osteoporosis model remain unclear. This work aimed to investigate the influence and the molecular mechanisms of AGEs on the osteogenic potential of ASCs. Read More

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http://dx.doi.org/10.1111/cpr.12834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309593PMC

lncRNA Oip5-as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR-29a to activate the SIRT1/AMPK/PGC1α pathway.

Cell Prolif 2020 Jun 28;53(6):e12818. Epub 2020 May 28.

Heart Center, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.

Objectives: Myocardial ischaemia/reperfusion (MI/R) injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanisms underlying MI/R injury are unclear. This study investigated the role of long non-coding RNA (lncRNA) Oip5-as1 in regulating mitochondria-mediated apoptosis during MI/R injury. Read More

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http://dx.doi.org/10.1111/cpr.12818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309946PMC

An approach using Caenorhabditis elegans screening novel targets to suppress tumour cell proliferation.

Cell Prolif 2020 Jun 25;53(6):e12832. Epub 2020 May 25.

Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital, Fudan University, Shanghai, China.

Objectives: Tumour cell proliferation requires high metabolism to meet the bioenergetics and biosynthetic needs. Dauer in Caenorhabditis elegans is characterized by lower metabolism, and we established an approach with C elegans to find potential tumour therapy targets.

Materials And Methods: RNAi screening was used to find dauer-related genes, and these genes were further analysed in glp-1(-) mutants for tumour-suppressing testing. Read More

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http://dx.doi.org/10.1111/cpr.12832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309951PMC

AFF1 inhibits adipogenic differentiation via targeting TGM2 transcription.

Cell Prolif 2020 Jun 22;53(6):e12831. Epub 2020 May 22.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Objectives: AF4/FMR2 family member 1 (AFF1), known as a central scaffolding protein of super elongation complex (SEC), regulates gene transcription. We previously reported that AFF1 inhibited osteogenic differentiation of human mesenchymal stromal/stem cells (hMSCs). However, its role in adipogenic differentiation has not been elucidated. Read More

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http://dx.doi.org/10.1111/cpr.12831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309944PMC

TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.

Cell Prolif 2020 Jun 17;53(6):e12829. Epub 2020 May 17.

Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

Objective: Acute kidney injury (AKI) is a common complication of acute liver failure (ALF). Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role of TNF-α/HMGB1 pathway in pyroptosis during ALF and AKI. Read More

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http://dx.doi.org/10.1111/cpr.12829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309595PMC

B-cell lymphoma 2 family genes show a molecular pattern of spatiotemporal heterogeneity in gynaecologic and breast cancer.

Cell Prolif 2020 Jun 17;53(6):e12826. Epub 2020 May 17.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.

Objectives: BCL2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti-cancer therapy. However, the similarities and differences in the spatial pattern of the BCL2 gene family within the context of chromatin have not been well characterized. We sought to fill this knowledge gap by assessing correlations between gene alteration, gene expression, chromatin accessibility, and clinical outcomes in gynaecologic and breast cancer. Read More

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http://dx.doi.org/10.1111/cpr.12826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309952PMC

Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17).

Cell Prolif 2020 Jun 13;53(6):e12827. Epub 2020 May 13.

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi'an, China.

Objectives: Previously, we found that by regulating T helper (Th) cell polarization, calcitriol intervention inhibited lipopolysaccharide (LPS)-induced alveolar bone loss in an animal periodontitis model, but the underlying cellular events remain unknown.

Materials And Methods: In this study, mouse Th cells were incubated in an inflammatory environment in the presence of dendritic cells (DCs) and LPS. Then, the potential of the Th cells to undergo Th2/Th17 polarization, the RANKL expression of the polarized Th cells and the subsequent influences of the polarized Th cells on RAW264. Read More

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http://dx.doi.org/10.1111/cpr.12827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309596PMC

Cadmium induces mitophagy via AMP-activated protein kinases activation in a PINK1/Parkin-dependent manner in PC12 cells.

Cell Prolif 2020 Jun 12;53(6):e12817. Epub 2020 May 12.

College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.

Objectives: Cadmium (Cd) induces mitophagy in neuronal cells, but the underlying mechanisms remain unknown. In this study, we aimed to investigate these mechanisms.

Materials And Methods: The effects of Cd on the mitophagy in rat pheochromocytoma PC12 cells were detected, and the role of PINK1/Parkin pathway in Cd-induced mitophagy was also analysed by using PINK1 siRNA. Read More

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http://dx.doi.org/10.1111/cpr.12817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309594PMC

Role of exosomal microRNAs in lung cancer biology and clinical applications.

Cell Prolif 2020 Jun 11;53(6):e12828. Epub 2020 May 11.

Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.

Exosomes, small extracellular vesicles ranging from 30 to 150 nm, are secreted by various cell types, including tumour cells. Recently, microRNAs (miRNAs) were identified to be encapsulated and hence protected from degradation within exosomes. These exosomal miRNAs can be horizontally transferred to target cells, in which they subsequently modulate biological processes. Read More

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http://dx.doi.org/10.1111/cpr.12828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309943PMC

Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes.

Cell Prolif 2020 Jun 11;53(6):e12825. Epub 2020 May 11.

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

Objectives: Little is known about the roles of integral membrane proteins beyond channels, carriers or receptors in meiotic oocytes. The transmembrane protein Fam70A was previously identified as a likely "female fertility factor" in Fox3a-knockout mouse ovaries where almost all follicles underwent synchronous activation and the mice became infertile very early. However, whether Fam70A functions in oocyte meiosis remains unknown. Read More

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http://dx.doi.org/10.1111/cpr.12825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309945PMC

Common and different alterations of bone marrow mesenchymal stromal cells in myelodysplastic syndrome and multiple myeloma.

Cell Prolif 2020 May 5;53(5):e12819. Epub 2020 May 5.

Catholic Genetic Laboratory Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objective: The objective of this study was to explore characteristics of bone marrow mesenchymal stromal cells (BM-MSCs) derived from patients with myelodysplastic syndrome (MDS) and multiple myeloma (MM).

Methods: BM-MSCs were recovered from 17 of MDS patients, 23 of MM patients and 9 healthy donors and were passaged until proliferation stopped. General characteristics and gene expression profiles of MSCs were analysed. Read More

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http://dx.doi.org/10.1111/cpr.12819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260074PMC
May 2020
3.116 Impact Factor

The overexpression of long intergenic ncRNA00162 induced by RelA/p65 promotes growth of pancreatic ductal adenocarcinoma.

Cell Prolif 2020 May 4;53(5):e12805. Epub 2020 May 4.

Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Objectives: Recent observations have emphasized the role of long non-coding RNA (lncRNA) in cancer progression; however, a genetic profile of lncRNAs in pancreatic ductal adenocarcinoma (PDAC) remains an ongoing study.

Materials And Methods: In this research, RNA sequencing showed that LINC00162 is dramatically increased in patient-derived tumour cell lines (PATC) compared with the human pancreatic nestin-positive epithelial (HPNE) cells.

Results: These data were validated in several PDAC cell lines, and significant upregulation of LINC00162 was found in all of them. Read More

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http://dx.doi.org/10.1111/cpr.12805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260071PMC

Sulphur doped carbon dots enhance photodynamic therapy via PI3K/Akt signalling pathway.

Cell Prolif 2020 May 4;53(5):e12821. Epub 2020 May 4.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Objectives: Photodynamic therapy (PDT) is a promising approach for cancer treatment, and the underlying signalling pathway changes has been carried out for studying the PDT mechanisms, but is majorly limited to organic photosensitizers (PSs). For the emerging nano-PSs typically possessing higher O quantum yield, few mechanistic studies were carried out, which limited their further applications in clinical therapeutics. PI3K/Akt signalling pathway, a most frequently activated signalling network in cancers, could promote cancer cell survival, but was seldom reported in previous PDT studies mediated by nano-PSs. Read More

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http://dx.doi.org/10.1111/cpr.12821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260068PMC

Comparison of gene disruption induced by cytosine base editing-mediated iSTOP with CRISPR/Cas9-mediated frameshift.

Cell Prolif 2020 May 29;53(5):e12820. Epub 2020 Apr 29.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.

Objectives: Recently developed CRISPR-dependent cytosine base editor (CBE), converting four codons (CAA, CAG, CGA and TGG) into stop codons without DNA double-strand breaks (DSB), serves as an efficient gene disruption strategy besides uncontrollable CRISPR-mediated frameshift. However, the detailed difference of gene knockout between the two systems has not been clarified.

Materials And Methods: Here, we selected some sgRNAs with different position background, then HEK293T cells were transfected with CBE/Cas9 plasmids together with sgRNAs. Read More

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http://dx.doi.org/10.1111/cpr.12820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260061PMC

Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.

Cell Prolif 2020 May 29;53(5):e12816. Epub 2020 Apr 29.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Objectives: Accumulated evidence suggests that Pin1 contributes to oncogenesis of diverse cancers. However, the underlying mechanism of oncogenic function of Pin1 in PDAC requires further exploration.

Materials And Methods: IHC was performed using PDAC tissues. Read More

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http://dx.doi.org/10.1111/cpr.12816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260075PMC

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration.

Cell Prolif 2020 May 29;53(5):e12808. Epub 2020 Apr 29.

Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.

Objectives: Although the hepatomitogenic activity of triiodothyronine (T3) is well established, the wide range of harmful effects exerted by this hormone precludes its use in liver regenerative therapy. Selective agonists of the beta isoform of thyroid hormone receptor (TRβ) do not exhibit T3-induced cardiotoxicity and show a good safety profile in patients with NASH. The aim of this study was to investigate whether two novel TRβ agonists, the prodrug TG68 and the active compound IS25 could stimulate hepatocyte proliferation without T3/TRα-dependent side effects. Read More

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http://dx.doi.org/10.1111/cpr.12808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260063PMC

Linc02349 promotes osteogenesis of human umbilical cord-derived stem cells by acting as a competing endogenous RNA for miR-25-3p and miR-33b-5p.

Cell Prolif 2020 May 29;53(5):e12814. Epub 2020 Apr 29.

Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang, China.

Objectives: Increasing evidences suggest that inducing mesenchymal stem cells to differentiate into osteoblasts has been as an especially important component in the prevention and therapy for degenerative bone disease. Here, we identify a novel lncRNA, linc02349, which increases significantly during osteogenic differentiation.

Materials And Methods: Human umbilical cord-derived stem cells (hUC-MSCs) and dental pulp mesenchymal stem cells were used. Read More

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http://dx.doi.org/10.1111/cpr.12814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260076PMC

Integration of nano- and biotechnology for beta-cell and islet transplantation in type-1 diabetes treatment.

Cell Prolif 2020 May 27;53(5):e12785. Epub 2020 Apr 27.

Biotalentum Ltd, Hungary, Godollo, Hungary.

Regenerative medicine using human or porcine β-cells or islets has an excellent potential to become a clinically relevant method for the treatment of type-1 diabetes. High-resolution imaging of the function and faith of transplanted porcine pancreatic islets and human stem cell-derived beta cells in large animals and patients for testing advanced therapy medicinal products (ATMPs) is a currently unmet need for pre-clinical/clinical trials. The iNanoBIT EU H2020 project is developing novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole-body distribution of the cellular transplants in a porcine diabetes model with excellent translational potential to humans. Read More

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http://dx.doi.org/10.1111/cpr.12785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260069PMC

Sulphur-doped carbon dots as a highly efficient nano-photodynamic agent against oral squamous cell carcinoma.

Cell Prolif 2020 Apr;53(4):e12786

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Objectives: Photodynamic therapy (PDT) is a novel non-invasive therapeutic method, which has been widely applied for the treatment of human oral cancers. However, the problems of undesirable singlet oxygen ( O ) quantum yields and long-term phototoxicity were inevitable during the application of traditional photosensitizers. Therefore, it is necessary to explore novel photosensitizers for the improvement of therapeutic effects. Read More

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http://dx.doi.org/10.1111/cpr.12786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162798PMC

H3K27ac-activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR-450b-5p/miR-515-5p/YAP1 axis.

Cell Prolif 2020 May 16;53(5):e12797. Epub 2020 Apr 16.

Department of Thoracic Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Objectives: Long non-coding RNAs (lncRNAs) are extensively reported as participants in the biological process of diverse malignancies, including lung squamous cell carcinoma (LUSC). Long intergenic non-protein coding RNA 519 (LINC00519) is identified as a novel lncRNA which has not yet been studied in cancers.

Materials And Methods: LINC00519 expression was detected by qRT-PCR. Read More

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http://dx.doi.org/10.1111/cpr.12797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260072PMC

Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation.

Cell Prolif 2020 May 14;53(5):e12802. Epub 2020 Apr 14.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Objectives: During human pregnancy, the endothelial cells of the uterine spiral arteries (SPA) are extensively replaced by a subtype of placental trophoblasts, endovascular extravillous trophoblasts (enEVTs), thus establishing a placental-maternal circulation. On this pathway, foetus-derived placental villi and enEVTs bath into the maternal blood that perfuses along SPA being not attacked by the maternal lymphocytes. We aimed to reveal the underlying mechanism of such immune tolerance. Read More

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http://dx.doi.org/10.1111/cpr.12802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260064PMC

Potential role of insulin on the pathogenesis of depression.

Cell Prolif 2020 May 13;53(5):e12806. Epub 2020 Apr 13.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.

The regulation of insulin on depression and depression-like behaviour has been widely reported. Insulin and activation of its receptor can promote learning and memory, affect the hypothalamic-pituitary-adrenal axis (HPA) balance, regulate the secretion of neurotrophic factors and neurotransmitters, interact with gastrointestinal microbiome, exert neuroprotective effects and have an impact on depression. However, the role of insulin on depression remains largely unclear. Read More

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http://dx.doi.org/10.1111/cpr.12806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260070PMC

Interleukin-11 regulates the fate of adipose-derived mesenchymal stem cells via STAT3 signalling pathways.

Cell Prolif 2020 May 9;53(5):e12771. Epub 2020 Apr 9.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: Adipose-derived mesenchymal stem cells (ADSCs) offer great promise as cell therapy for ischaemic diseases. Due to their poor survival in the ischaemic environment, the therapeutic efficacy of ADSCs is still relatively low. Interleukin-11 (IL-11) has been shown to play a key role in promoting cell proliferation and protecting cells from oxidative stress injury. Read More

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http://dx.doi.org/10.1111/cpr.12771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260062PMC
May 2020
3.116 Impact Factor

Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.

Cell Prolif 2020 May 7;53(5):e12804. Epub 2020 Apr 7.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, China.

Major depressive disorder takes at least 3 weeks for clinical anti-depressants, such as serotonin selective reuptake inhibitors, to take effect, and only one-third of patients remit. Ketamine, a kind of anaesthetic, can alleviate symptoms of major depressive disorder patients in a short time and is reported to be effective to treatment-resistant depression patients. The rapid and strong anti-depressant-like effects of ketamine cause wide concern. Read More

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http://dx.doi.org/10.1111/cpr.12804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260066PMC

Systematic characterization of non-coding RNAs in triple-negative breast cancer.

Cell Prolif 2020 May 6;53(5):e12801. Epub 2020 Apr 6.

Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non-coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis and development of TNBC, but the functions of most ncRNAs have not been fully described. Read More

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http://dx.doi.org/10.1111/cpr.12801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260065PMC