475,503 results match your criteria Cell Death & Disease [Journal]


Drug repurposing: Discovery of troxipide analogs as potent antitumor agents.

Eur J Med Chem 2020 Jun 26;202:112471. Epub 2020 Jun 26.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clinical drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three cancer cell lines and WPMY-1. Compound 5q, especially, could effectively inhibit PC3 with an IC value of 0. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112471DOI Listing

The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia.

Pharmacol Res 2020 Jun 30:105058. Epub 2020 Jun 30.

Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea. Electronic address:

Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL) cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to be an attractive option to prevent TKI resistance, considering the potential capacity of an HDAC6i to diminish BCR-ABL expression. We first validated the in vivo anti-cancer potential of the compound 7b by significantly reducing the tumor burden of BALB/c mice xenografted with K-562 cells, without notable organ toxicity. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.105058DOI Listing

(-)-Kusunokinin inhibits breast cancer in N-nitrosomethylurea-induced mammary tumor rats.

Eur J Pharmacol 2020 Jun 30:173311. Epub 2020 Jun 30.

Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; The Excellent Research Laboratory of Cancer Molecular Biology, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. Electronic address:

Natural and synthetic (-)-kusunokinin inhibited breast cancer, colon cancer and cholangiocarcinoma cells at the G2/M phase and induced apoptosis. However, there is no report on the action and adverse effects of (-)-kusunokinin in animal models. In this study, we investigated the cytotoxic effect of (-)-kusunokinin from Piper nigrum on cancer cells. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173311DOI Listing

Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p.

Acta Biomater 2020 Jun 30. Epub 2020 Jun 30.

Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China. Electronic address:

Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) (MSC-EVs) exhibit protective effects in damaged or diseased tissues. However, the role of EVs secreted by MSC in hypoxia-ischemic (HI) injury in neonatal mice remains unknown. Systemic administration of MSC-EVs attenuated acute brain damage and neuroinflammation, and skewed CD11b/CD45 microglia and CD11b/CD45 brain monocyte/macrophage towards a more anti-inflammatory property as determined at 72 h post-HI. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.037DOI Listing

TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats.

Behav Brain Res 2020 Jun 30:112781. Epub 2020 Jun 30.

Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia. Electronic address:

Chronic cerebral hypoperfusion (CCH) been well characterized as a common pathological status contributing to neurodegenerative diseases such as Alzheimer's disease and vascular dementia. CCH is an important factor that leads to cognitive impairment, but the underlying neurobiological mechanism is poorly understood and no effective treatment is available. Recently, transient receptor potential melastatin 4 (TRPM4) cation channel has been identified as an important molecular element in focal cerebral ischemia. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112781DOI Listing

Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network.

Food Chem Toxicol 2020 Jun 30:111517. Epub 2020 Jun 30.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address:

Prostate cancer (PCa) depends on androgen receptor (AR) signaling to regulate cell metabolism, including glycolysis, and thereby promotes tumor growth. Glycolysis is overactive in PCa and associated with poor prognosis, but the therapeutic efficacy of glycolysis inhibitors has thus far been limited by their inability to induce cell death. FV-429, a flavonoid derivative of Wogonin, is a glycolysis inhibitor that has shown anti-cancer promise. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111517DOI Listing

Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome.

Cell Syst 2020 Jul 1. Epub 2020 Jul 1.

Division of Genetics, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

All mammals progress through similar physiological stages throughout life, from early development to puberty, aging, and death. Yet, the extent to which this conserved physiology reflects underlying genomic events is unclear. Here, we map the common methylation changes experienced by mammalian genomes as they age, focusing on comparison of humans with dogs, an emerging model of aging. Read More

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http://dx.doi.org/10.1016/j.cels.2020.06.006DOI Listing

Emerging roles of long non-coding RNAs in breast cancer biology and management.

Semin Cancer Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", Rome, Italy; Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy. Electronic address:

Breast cancer is the most common cancer in women with the highest mortality among this gender. Despite treatment strategies including surgery, hormone therapy and targeted therapy have recently advanced, innovative biomarkers are needed for the early detection, treatment and prognosis. An increasing number of non-coding RNAs (ncRNAs) have shown great potential as crucial players in different stages of the breast cancer tumorigenesis, influencing cell death, metabolism, epithelial-mesenchymal transition (EMT), metastasis and drug resistance. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.06.019DOI Listing

Thiosulfinate Tolerance Is a Virulence Strategy of an Atypical Bacterial Pathogen of Onion.

Curr Biol 2020 Jun 26. Epub 2020 Jun 26.

University of Georgia, Department of Plant Biology, Carleton St., Athens, GA 30602, USA; University of Georgia, The Plant Center, Carleton St., Athens, 30602, Athens, GA 30602, USA. Electronic address:

Unlike most characterized bacterial plant pathogens, the broad-host-range plant pathogen Pantoea ananatis lacks both the virulence-associated type III and type II secretion systems. In the absence of these typical pathogenicity factors, P. ananatis induces necrotic symptoms and extensive cell death in onion tissue dependent on the HiVir proposed secondary metabolite synthesis gene cluster. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.092DOI Listing

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.

Lancet Haematol 2020 Jun 30. Epub 2020 Jun 30.

Section of Hematology, New Haven, CT, USA. Electronic address:

Background: An important feature of severe acute respiratory syndrome coronavirus 2 pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic and microvascular complications. Previous studies have suggested a role for endothelial cell injury in COVID-19-associated coagulopathy. To determine whether endotheliopathy is involved in COVID-19-associated coagulopathy pathogenesis, we assessed markers of endothelial cell and platelet activation in critically and non-critically ill patients admitted to the hospital with COVID-19. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30216-7DOI Listing

New Insights in Gene Expression Alteration as Effect of Paclitaxel Drug Resistance in Triple Negative Breast Cancer Cells.

Cell Physiol Biochem 2020 Jul;54(4):648-664

Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background/aims: Triple negative breast cancer (TNBC) is a highly aggressive form of cancer which lacks targeted therapy options. Thus, TNBC patients have poor outcomes and a decreased survival rate than patients with other types of breast cancers. Due to the lack of surface receptors, TNBC needs a comprehensive investigation to provide more information regarding patient's therapy, as well as to understand the way how to counteract drug resistance mechanisms. Read More

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http://dx.doi.org/10.33594/000000246DOI Listing

A Review of Preclinical Research on the Effects of Photodynamic Therapy and Homeopathic Medicine on Cancer Cells.

Altern Ther Health Med 2020 Jul 1. Epub 2020 Jul 1.

Context: Cancer occurs as a consequence of the dysregulation of genes during cell division, resulting in an increased proliferation rate and loss of vital checkpoints in cells. Photodynamic therapy (PDT) makes use of photosensitizers, oxygen, and light at visible wavelengths to stimulate formation of reactive oxygen species (ROS) and trigger apoptosis of cancer cells. Homeopathic remedies commonly affect genes, including tumor necrosis factor alpha (TNF-α) and Bcl2, thereby stimulating cancer-cell death. Read More

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Exploring the Role of Phytochemicals as Potent Natural Photosensitizers in Photodynamic Therapy.

Anticancer Agents Med Chem 2020 Jul 3. Epub 2020 Jul 3.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein. South Africa.

Background: Cancer is still viewed as a deadly disease worldwide due to difficulties in diagnosis, painful treatment procedures, costly therapies, side effects and cancer relapse. Cancer treatments using conventional methods like chemotherapy and radiotherapy were not convincing due to its post-treatment toxicity in the host. In Photodynamic Therapy (PDT) three individual non-toxic components including a photosensitizer, light source and oxygen causes damage to the cells and tissues when they are combined. Read More

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http://dx.doi.org/10.2174/1871520620666200703192127DOI Listing

Correlation Between BCL2 And Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer.

Curr Pharm Biotechnol 2020 Jul 3. Epub 2020 Jul 3.

Departemnt of Clinical Pharmacy, Jordan University of Science and Technology, Irbid. Jordan.

Background: Colorectal cancer is one of the most common types of cancer worldwide and a leading cause of death in Jordan. BCL-2 and MCL-1 are antiapoptotic proteins that inhibit programmed cell death and their over-expression has been shown to be associated with reduced sensitivity to chemotherapy and poor survival in cancer patients.

Objective: In the present study, three SNPs in the promoter region of antiapoptotic genes were investigated in an effort to inspect the occurrences of SNPs (rs2279115, rs4987852) in the promoter region of BCL2 and SNP (rs9803935) in the promoter region of MCL1 in Jordanian patients with CRC, and investigate correlations between BCL2 and MCL1 SNPs and clinical outcomes. Read More

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http://dx.doi.org/10.2174/1389201021666200703200126DOI Listing

Development of a novel anti-biofilm peptide derived from profilin of .

Biofouling 2020 Jul 3:1-11. Epub 2020 Jul 3.

Protein Purification Laboratory and Biological Functions, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.

yeast infections are the fourth leading cause of death worldwide. Peptides with antimicrobial activity are a promising alternative treatment for such infections. Here, the antifungal activity of a new antimicrobial peptide-PEP-IA18-was evaluated against species. Read More

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http://dx.doi.org/10.1080/08927014.2020.1776857DOI Listing

10H-3,6-Diazaphenothiazines triggered the mitochondrial-dependent and cell death receptor-dependent apoptosis pathways and further increased the chemosensitivity of MCF-7 breast cancer cells via inhibition of AKT1 pathways.

J Biochem Mol Toxicol 2020 Jul 3:e22544. Epub 2020 Jul 3.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Breast cancer is one of the leading causes of death in cancer categories, followed by lung, colorectal, and ovarian among the female gender across the world. 10H-3,6-diazaphenothiazine (PTZ) is a thiazine derivative compound that exhibits many pharmacological activities. Herein, we proceed to investigate the pharmacological activities of PTZ toward breast cancer MCF-7 cells as a representative in vitro breast cancer cell model. Read More

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http://dx.doi.org/10.1002/jbt.22544DOI Listing

Pancreas preservation: clinical practice and future developments.

Curr Opin Organ Transplant 2020 Jun 30. Epub 2020 Jun 30.

Nuffield Department of Surgical Sciences, University of Oxford and Oxford Biomedical Research Centre, Oxford, UK.

Purpose Of Review: To summarize recently published studies of preservation strategies including machine perfusion in pancreas transplantation.

Recent Findings: The shortage of conventional donors is leading units to use extended criteria donors (ECDs) and donors after cardiac death (DCD). Static cold storage (SCS) is still the standard method of preservation for pancreases and University of Wisconsin remains the gold standard preservation solution. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000784DOI Listing

The role of beta-cell dysfunction in early type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2020 Aug;27(4):215-224

Department of Pediatrics.

Purpose Of Review: Emerging data have suggested that β-cell dysfunction may exacerbate the development and progression of type 1 diabetes (T1D). In this review, we highlight clinical and preclinical studies suggesting a role for β-cell dysfunction during the evolution of T1D and suggest agents that may promote β-cell health in T1D.

Recent Findings: Metabolic abnormalities exist years before development of hyperglycemia and exhibit a reproducible pattern reflecting progressive deterioration of β-cell function and increases in β-cell stress and death. Read More

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http://dx.doi.org/10.1097/MED.0000000000000548DOI Listing

Ectodermal-neural cortex 1 as a novel biomarker predicts poor prognosis and induces metastasis in breast cancer by promoting Wnt/β-catenin pathway.

J Cell Mol Med 2020 Jul 3. Epub 2020 Jul 3.

Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Breast cancer, as the most common malignancy, is the second leading cause of cancer-related death in women. One of the kelch family member ENC1 is involved in various pathophysiologic processes. But the role of ENC1 in breast cancer has not been investigated. Read More

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http://dx.doi.org/10.1111/jcmm.15520DOI Listing

Clinical and Laboratory Profile of Fatal Dengue Cases at a Tertiary Care Private Hospital in Mumbai, India.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Critical Care, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India.

Dengue-related mortality has significantly reduced with early and appropriate fluid resuscitation. However, we continue to see dengue-related fatalities in patients despite early intervention and advanced critical care support. This was a retrospective study conducted at a tertiary care private hospital in Mumbai, India. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0425DOI Listing

The Leaf Extracts of and Fermented Culture Broths of Synergistically Cause Apoptotic Cell Death in Promyelocytic Leukemia Cells.

Integr Cancer Ther 2020 Jan-Dec;19:1534735420923734

Department of Cosmeceutics, School of Pharmacy, China Medical University, Taichung, Taiwan.

is a common edible vegetable that is used in certain Chinese dishes and has importance in folk medicine. The leaf extracts of possess and exhibit anticancer efficacy against various cancer cell types. In Taiwanese folklore, , also known as "Niu-Cheng-Zi," is used in traditional medicine to treat various illnesses. Read More

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http://dx.doi.org/10.1177/1534735420923734DOI Listing

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice.

Mov Disord 2020 Jul 3. Epub 2020 Jul 3.

Centre for Neuroscience, Indian Institute of Science, Bangalore, India.

Background: Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell death and cell survival signaling pathways in these neurons. Glutaredoxin 1 (Grx1) is a thiol/disulfide oxidoreductase that catalyzes the deglutathionylation of proteins and is important for regulation of cellular protein thiol redox homeostasis. Read More

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http://dx.doi.org/10.1002/mds.28190DOI Listing

The critically ill brain after cardiac arrest.

Ann N Y Acad Sci 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, New York University Langone Medical Center, New York, New York.

Cardiac arrest can cause hypoxic-anoxic ischemic brain injury due to signaling cascades that lead to damaged cell membranes and vital cellular organelles, resulting in cell death in the setting of low or no oxygen. Some brain areas are more prone to damage than others, so patients with hypoxic-anoxic ischemic brain injury present with several outcomes, including reduced level of consciousness or alertness, memory deficits, uncoordinated movements, and seizures. Some patients may have mild deficits, while others may have such severe injury that it can progress to brain death. Read More

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http://dx.doi.org/10.1111/nyas.14423DOI Listing

Does JNK Regulate Acetaminophen Hepatotoxicity by Modulating Nrf2-dependent Genes or Mitochondrial Oxidant Stress?

Hepatology 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas, Medical Center, Kansas City, USA.

We read with interest the recent paper by Chen and coworkers who provided evidence for Nrf2 as a novel target for c-jun N-terminal kinase (JNK). Although we agree that JNK activation is a critical part of the signaling mechanism of acetaminophen (APAP) hepatotoxicity, we disagree with the conclusion that P-JNK phosphorylation of Nrf2 causing down-regulation of Nrf2-dependent antioxidant response element (ARE)-driven genes Nqo1, Gstα3, Gstm1 and Gstm5 is the critical mechanism by which JNK promotes APAP-induced cell death. First, although JNK appears to phosphorylate Nrf2 in vivo as early as 3-6 h after APAP administration, the effects of the JNK inhibitor SP600125 on expression of these proteins was not observed during the main injury phase (6 h) but only at 24 h, i. Read More

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http://dx.doi.org/10.1002/hep.31442DOI Listing

Cancer and Alzheimer's disease: intracellular pH scales the metabolic disorders.

Biogerontology 2020 Jul 2. Epub 2020 Jul 2.

Research Laboratory in Applied Metabolic Engineering, Department of Chemical, Engineering, Ecole Polytechnique de Montréal, Montréal, QC, Canada.

Alzheimer's disease (AD) and cancer have much in common than previously recognized. These pathologies share common risk factors (inflammation and aging), with similar epidemiological and biochemical features such as impaired mitochondria. Metabolic reprogramming occurs during aging and inflammation. Read More

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http://dx.doi.org/10.1007/s10522-020-09888-6DOI Listing

Comprehensive characterization of tumor mutation burden in clear cell renal cell carcinoma based on the three independent cohorts.

J Cancer Res Clin Oncol 2020 Jul 2. Epub 2020 Jul 2.

Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas (Putian University) Fujian Provincial University, Key Laboratory of Loquat Germplasm Innovation and Utilization (Putian University), Fujian Province University, College of Environmental and Biological Engineering, Putian University, Putian, 351100, Fujian, China.

Purpose: With the wide application of high-throughput sequencing and the development of multiomics analysis, somatic mutational profiling has demonstrated that there is heterogeneity across multiple malignancies. Meanwhile, tumor mutational burden (TMB) was proven to be effective predictors of immunotherapy response. However, the significance of TMB in predicting prognosis remains unclear. Read More

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http://dx.doi.org/10.1007/s00432-020-03299-3DOI Listing

Flavonoid calycopterin triggers apoptosis in triple-negative and ER-positive human breast cancer cells through activating different patterns of gene expression.

Naunyn Schmiedebergs Arch Pharmacol 2020 Jul 2. Epub 2020 Jul 2.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.

Breast cancer is the most common cause of death related to cancer in women, and several studies proved that flavonoids could induce apoptosis in this cancer through different pathways. Calycopterin is a flavonoid which was shown to induce preferential antiproliferative effects on some cancers; however, no information is available on its effect on breast cancer. Therefore, in this paper, the apoptotic effect of calycopterin and its underlying mechanism in two different breast cancer cells, MDA-MB-231 and MCF7 cell lines were investigated. Read More

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http://dx.doi.org/10.1007/s00210-020-01917-yDOI Listing

Checkpoint inhibitor-induced myocarditis and myasthenia gravis in a recurrent/metastatic thymic carcinoma patient: a case report.

Eur Heart J Case Rep 2020 Jun 7;4(3):1-8. Epub 2020 Apr 7.

Heart and Vascular Center, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA.

Background: Pembrolizumab, an immune checkpoint inhibitor (ICI), is an IgG4 antibody that blocks interaction between programmed cell death protein 1 and programmed death-ligand 1. Myocarditis, an immune-related adverse event, has been reported in thymic epithelial tumours. Pembrolizumab has also been associated with development/exacerbation of myasthenia gravis (MG). Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319805PMC

Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.

Oxid Med Cell Longev 2020 11;2020:6973636. Epub 2020 Jun 11.

Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.

Pulmonary arterial hypertension (PAH) is a lethal disease generally characterized by pulmonary artery remodeling. Mitochondrial metabolic disorders have been implicated as a critical regulator of excessively proliferative- and apoptosis-resistant phenotypes in pulmonary artery smooth muscle cells (PASMCs). Dichloroacetate (DCA) is an emerging drug that targets aerobic glycolysis in tumor cells. Read More

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http://dx.doi.org/10.1155/2020/6973636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306075PMC

Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity.

Oxid Med Cell Longev 2020 16;2020:6340190. Epub 2020 Jun 16.

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Surgical intervention is currently the only option for an abdominal aortic aneurysm (AAA), preventing its rupture and sudden death of a patient. Therefore, it is crucial to determine the pathogenic mechanisms of this disease for the development of effective pharmacological therapies. Oxidative stress is said to be one of the pivotal factors in the pathogenesis of AAAs. Read More

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http://dx.doi.org/10.1155/2020/6340190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315306PMC

Sorafenib and Mesenchymal Stem Cell Therapy: A Promising Approach for Treatment of HCC.

Evid Based Complement Alternat Med 2020 14;2020:9602728. Epub 2020 Jun 14.

Tehran University of Medical Sciences (TUMS), Tissue Engineering & Applied Cell Sciences, Tehran, Iran.

Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer and the second most common cause of cancer-related death worldwide. Sorafenib (Sora) is used as a targeted therapy for HCC treatment. Mesenchymal stem cells (MSCs) are applied as a new approach to fight malignancies. Read More

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http://dx.doi.org/10.1155/2020/9602728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312705PMC

Cortex Granules Attenuate Virulence by Targeting Pneumolysin.

Evid Based Complement Alternat Med 2020 16;2020:8537026. Epub 2020 Jun 16.

Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.

Pore-forming toxins produced by bacteria are some of the most important molecular weapons for bacterial virulence. Pneumolysin (PLY) is a pore-forming toxin secreted by () and plays a vital role in the spread, colonization, and invasion of this bacterium in the host, indicating that PLY is a promising target for developing treatments against infection. In this study, Cortex granules (CCCGs), a prescription drug on the market, were shown to inhibit the pore-forming activity of PLY and protect against PLY-mediated cell hemolysis and A549 cell death without antibacterial activity or inhibition of PLY production. Read More

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http://dx.doi.org/10.1155/2020/8537026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315261PMC

Korean Red Ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derived neurotrophic factor upregulation.

J Ginseng Res 2020 Jul 24;44(4):593-602. Epub 2019 May 24.

School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Background: Heat stress orchestrates neurodegenerative disorders and results in the formation of reactive oxygen species that leads to cell death. Although the immunomodulatory effects of ginseng are well studied, the mechanism by which ginseng alleviates heat stress in the brain remains elusive.

Methods: Rats were exposed to intermittent heat stress for 6 months, and brain samples were examined to elucidate survival and antiinflammatory effect after Korean Red Ginseng (KRG) treatment. Read More

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http://dx.doi.org/10.1016/j.jgr.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322747PMC

Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma.

Sci Rep 2020 Jul 2;10(1):10881. Epub 2020 Jul 2.

Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 216-8511, Japan.

It is unclear how epidermal growth factor receptor EGFR major driver mutations (L858R or Ex19del) affect downstream molecular networks and pathways. This study aimed to provide information on the influences of these mutations. The study assessed 36 protein expression profiles of lung adenocarcinoma (Ex19del, nine; L858R, nine; no Ex19del/L858R, 18). Read More

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http://dx.doi.org/10.1038/s41598-020-67894-7DOI Listing

Blockade of PD-1, PD-L1, and TIM-3 Altered Distinct Immune- and Cancer-Related Signaling Pathways in the Transcriptome of Human Breast Cancer Explants.

Genes (Basel) 2020 Jun 25;11(6). Epub 2020 Jun 25.

Cancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha 34110, Qatar.

Immune checkpoint inhibitors (ICIs) are yet to have a major advantage over conventional therapies, as only a fraction of patients benefit from the currently approved ICIs and their response rates remain low. We investigated the effects of different ICIs-anti-programmed cell death protein 1 (PD-1), anti-programmed death ligand-1 (PD-L1), and anti-T cell immunoglobulin and mucin-domain containing-3 (TIM-3)-on human primary breast cancer explant cultures using RNA-Seq. Transcriptomic data revealed that PD-1, PD-L1, and TIM-3 blockade follow unique mechanisms by upregulating or downregulating distinct pathways, but they collectively enhance immune responses and suppress cancer-related pathways to exert anti-tumorigenic effects. Read More

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http://dx.doi.org/10.3390/genes11060703DOI Listing

A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone.

J Immunother Cancer 2020 Jul;8(2)

Cell, Development & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.

Background: Checkpoint inhibitors can induce profound anticancer responses, but programmed cell death protein-1 (PD-1) inhibition monotherapy has shown minimal activity in prostate cancer. A published report showed that men with prostate cancer who were resistant to the second-generation androgen receptor inhibitor enzalutamide had increased programmed death-ligand 1 (PD-L1) expression on circulating antigen-presenting cells. We hypothesized that the addition of PD-1 inhibition in these patients could induce a meaningful cancer response. Read More

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http://dx.doi.org/10.1136/jitc-2020-000642DOI Listing

Atezolizumab-induced type 1 diabetes mellitus in a patient with metastatic renal cell carcinoma.

BMJ Case Rep 2020 Jul 2;13(7). Epub 2020 Jul 2.

Department of Medicine, University of Maryland Baltimore, Baltimore, Maryland, USA

Checkpoint inhibitor immunotherapy has revolutionised cancer treatment since its inception. During an inflammatory response, activated cytotoxic T cells expressing programmed cell death protein 1 (PD-1) interact with programmed cell death-ligand 1 (PD-L1) on peripheral tissues to thwart an autoimmune reaction. Cancer cells upregulate PD-L1 expression to evade the immune system and are vulnerable to attack in the presence of PD-1 or PD-L1 checkpoint inhibitors. Read More

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http://dx.doi.org/10.1136/bcr-2019-233842DOI Listing

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.

Genes Dev 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulators of peptidergic secretion within pancreatic β cells that are perturbed in and β-cell lines. We show that the RNA-binding protein THRAP3 (thyroid hormone receptor-associated protein 3) regulates circadian clock-dependent AS by binding to exons at coding sequences flanking exons that are more frequently skipped in clock mutant β cells, including transcripts encoding () and (). Read More

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http://dx.doi.org/10.1101/gad.338178.120DOI Listing

Early Relapse Risk in Newly Diagnosed Multiple Myeloma Patients Characterized by Next-Generation Sequencing.

Clin Cancer Res 2020 Jul 2. Epub 2020 Jul 2.

Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino

Introduction: Duration of first remission is important for the survival of multiple myeloma (MM) patients.

Methods: From the CoMMpass study (NCT01454297), 926 newly diagnosed MM patients, characterized by next-generation sequencing, were analyzed to evaluate those who experienced early progressive disease (PD) (time to progression, TTP≤18 months).

Results: After a median follow-up of 39 months, early PD was detected in 191/926 (20. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0951DOI Listing

Regulatory mechanisms of RIPK1 in cell death and inflammation.

Semin Cell Dev Biol 2020 Jun 29. Epub 2020 Jun 29.

Department of Immunology, Duke University School of Medicine, Durham, NC, 27710-3010, United States. Electronic address:

Receptor Interacting Protein Kinase 1 (RIPK1) and RIPK3 are key adaptors that play critical roles in inflammatory and cell death signaling. Work in recent years have shown that their activities are tightly regulated by ubiquitination, phosphorylation and proteolysis. In addition to these post-translational modifications, the expression and activities of these kinases can further be tuned by environmental changes in pH and oxygen content. Read More

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http://dx.doi.org/10.1016/j.semcdb.2020.06.013DOI Listing

Cellular markers of mule duck livers after force-feeding.

Poult Sci 2020 Jul 25;99(7):3567-3573. Epub 2020 Apr 25.

GenPhySE, Université de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France. Electronic address:

The "Foie gras" or fatty liver is the result of hepatic steatosis from nutritional origin and induced by the force-feeding of palmipeds. Despite identical rearing and force-feeding conditions of ducks from the same breed, different liver weights, within a range of 500 to more than 700 g, are generally observed at the time of evisceration. To better understand the determinism of this large variability in fatty liver weights, the activity of various metabolic pathways has been explored in 4 groups of steatotic livers differing by their weights. Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.048DOI Listing

Dietary supplementation of 25-hydroxycholecalciferol improves cardiac function and livability in broiler breeder hens-amelioration of blood pressure and vascular remodeling.

Poult Sci 2020 Jul 17;99(7):3363-3373. Epub 2020 Apr 17.

Department of Animal Science, National Chung Hsing University, Taichung, Taiwan; Innovation and Development Center of Sustainable Agriculture (IDCSA), National Chung Hsing University, Taichung, Taiwan; The IEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Research Center for Sustainable Energy and Nanotechnology, National Chung Hsing University, Taichung, Taiwan. Electronic address:

A supplement of 69 μg 25-hydroxycholecalciferol (25-OH-D3)/kg feed suppressed the mortality in feed-restricted broiler breeder hens and in hens allowed ad libitum feed intake (Ad-hens) in a feeding trial from age 26 to 60 wk. Outcomes for the mechanisms found that 25-OH-D3 relieved systemic hypoxia, pathological cardiac remodeling and arrhythmias, and hepatopathology to improve hens' livability. In the study, we further evaluated the effect of 25-OH-D3 on blood pressure and vascular remodeling relative to cardiac pathogenesis of sudden death (SD). Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.015DOI Listing

Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells.

Chin J Nat Med 2020 Jul;18(7):517-525

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China. Electronic address:

Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell membrane. Mechanistically, NLE increased the phosphorylation and expression of c-Jun, and promoted the localization of c-Jun in the nucleus, while silencing of c-Jun by small interfering RNA (siRNA) reduced NLE-induced PD-L1. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30062-5DOI Listing

The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis.

Chin J Nat Med 2020 Jul;18(7):508-516

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000, China; Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, Nanning 530200, China.

Lung cancer is the leading cause of cancer death and the most common malignant tumor, the long-term survival of which has stagnated in the past several decades. Pileostegia tomentella Hand. Mazz is a traditional Chinese medicine called "Zhongliuteng" (ZLT) in the pharmacopeia, which has been proved to possess a potent anti-tumor effect on various cancers. Read More

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http://dx.doi.org/10.1016/S1875-5364(20)30061-3DOI Listing

Histopathological findings for prediction of liver cirrhosis and survival in biliary atresia patients after Kasai procedure.

Diagn Pathol 2020 Jul 2;15(1):79. Epub 2020 Jul 2.

Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Background: Without early recognition and Kasai procedure, biliary atresia (BA) results in liver cirrhosis and leads to either transplantation or death at a young age. We aimed to characterize the liver histopathological findings for prediction of cirrhosis and survival in BA patients after Kasai surgery.

Methods: We retrospectively reviewed all histopathological results for BA patients who underwent liver biopsy during Kasai surgery from August 2012 to December 2018 in Dr. Read More

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http://dx.doi.org/10.1186/s13000-020-00996-yDOI Listing

Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections.

Parasit Vectors 2020 Jul 2;13(1):336. Epub 2020 Jul 2.

Área de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Facultad de Farmacia, Universitat de València, Avda. Vicent Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain.

Background: Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, which has been extensively used to investigate the factors that determine the rejection of intestinal helminths. In this sense, several studies have shown that IL-25 is critical for the development of resistance against E. caproni in mice. Read More

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http://dx.doi.org/10.1186/s13071-020-04206-yDOI Listing

In-situ Monitoring of Mitochondria Regulating Cell Viability by the RNA-specific Fluorescent Photosensitizer.

Anal Chem 2020 Jul 3. Epub 2020 Jul 3.

Cell viability is greatly affected by external stimulus eliciting correlated dynamical physiological processes for cells to choose survival or death. A few fluorescent probes have been designed to detect whether the cell is in survival state or apoptotic state, but monitoring the regulation process of the cell undergoing survival to death remains a long-standing challenge. Herein, we highlight the in-situ monitor of mitochondria regulating the cell viability by the RNA-specific fluorescent photosensitizer L. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c02298DOI Listing

Clinical characteristics, histopathology, and tissue immunolocalization of chikungunya virus antigen in fatal cases.

Clin Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Centers for Disease Control and Prevention - Infectious Diseases Pathology Branch, Atlanta, Georgia, United States of America.

Background: Death in patients with chikungunya is rare, and has been associated with encephalitis, hemorrhage, and septic shock. We describe clinical, histologic and immunohistochemical findings in individuals who died following chikungunya virus (CHIKV) infection.

Methods: We identified individuals who died in Puerto Rico during 2014 following an acute illness, and had CHIKV RNA detected by RT-PCR in a pre- or post-mortem blood or tissue specimen. Read More

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http://dx.doi.org/10.1093/cid/ciaa837DOI Listing
July 2020
8.886 Impact Factor

Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.

Int Immunopharmacol 2020 Jun 29;86:106723. Epub 2020 Jun 29.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China. Electronic address:

Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug, but it comes with a high risk of drug-induced liver injury (DILI). Despite the quinone-imine adduct pathways, the immunotoxicity is recently considered as another factor for DILI. However, such immune responses are still elusive. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106723DOI Listing

Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics.

Nanomedicine 2020 Jun 29:102258. Epub 2020 Jun 29.

Center for NanoHealth, Swansea University Medical School.

High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (<90 μg/day). To enable the successful exploitation of selenium for cancer treatment, we evaluated inorganic selenium nanoparticles (SeNP), and found them effective in inhibiting ovarian cancer cell growth. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102258DOI Listing