499,951 results match your criteria Cell Death & Disease [Journal]


Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine.

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7-8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/hmg/ddz082DOI Listing
April 2019
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Induction of apoptosis in CD4(+) T-cells is linked with optimal treatment response in patients with relapsing-remitting multiple sclerosis treated with Glatiramer acetate.

J Neurol Sci 2019 Mar 29;401:43-50. Epub 2019 Mar 29.

Multiple Sclerosis Center, B' Neurological University Department, AHEPA General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address:

Background: Induction of T-cell apoptosis constitutes a mechanism of action for Glatiramer Acetate (GA). We investigated whether activation of apoptotic T-cell death may be indicative of optimal treatment response in patients with relapsing-remitting Multiple Sclerosis (RRMS), with respect to radiological activity.

Methods: We studied apoptotic markers on blood T-cells of forty patients with RRMS, 19 patients under GA and 21 patients under interferon-β (IFNβ), by flow cytometry. Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.030DOI Listing

miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.

Mol Ther Nucleic Acids 2019 Mar 13;16:391-406. Epub 2019 Mar 13.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli," 80138 Naples, Italy; IRGS, Biogem, Molecular and Precision Oncology Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address:

miR-125b, ubiquitously expressed and frequently dysregulated in several tumors, has gained special interest in the field of cancer research, displaying either oncogenic or oncosuppressor potential based on tumor type. We have previously demonstrated its tumor-suppressive role in multiple myeloma (MM), but the analysis of molecular mechanisms needs additional investigation. The purpose of this study was to explore the effects of miR-125b and its chemically modified analogs in modulating cell viability and cancer-associated molecular pathways, also focusing on the functional aspects of stress adaptation (autophagy and senescence), as well as programmed cell death (apoptosis). Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.023DOI Listing

5-Hydroxytryptamine1a receptors on tumour cells induce immune evasion in lung adenocarcinoma patients with depression via autophagy/pSTAT3.

Eur J Cancer 2019 Apr 19;114:8-24. Epub 2019 Apr 19.

Department of Oncology, XiangYang Central Hospital, Hubei University of Arts and Science, XiangYang 441021, China. Electronic address:

Background: Cancer patients frequently suffer from fatigue and depression. Dysregulation of the immune system, tumour recurrence and metastasis are more common in cancer patients with depression. 5-Hydroxytryptamine (5-HT), a neurotransmitter, contributes to immune evasion in lung adenocarcinoma patients by activating 5-HTRs, but the mechanism for this phenomenon is still unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193021
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http://dx.doi.org/10.1016/j.ejca.2019.03.017DOI Listing
April 2019
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Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective.

Nitric Oxide 2019 Apr 19. Epub 2019 Apr 19.

New York University School of Medicine, New York, NY, USA.

Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). Read More

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http://dx.doi.org/10.1016/j.niox.2019.04.009DOI Listing

Trafficking of a Single Photosensitizing molecule to Different Intracellular Organelles Demonstrates Effective Hydroxyl Radical-Mediated Photodynamic Therapy in the Endoplasmic Reticulum.

Bioconjug Chem 2019 Apr 22. Epub 2019 Apr 22.

Photodynamic therapy (PDT) is often used in preclinical and clinical treatment regimens. Reactive oxygen species (ROS) generated by photosensitizers (PSs) upon exposure to light induce cell death via diverse mechanisms. PSs can exert therapeutic effects in different cellular organelles, although the efficacy of organelle-specific PDT has yet to be determined as most previous studies use different PSs in different organelles. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00192DOI Listing

Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy.

PLoS One 2019 22;14(4):e0215547. Epub 2019 Apr 22.

Department of Mathematics, Konkuk University, Seoul, Republic of Korea.

Glioblastoma multiforme is one of the most invasive type of glial tumors, which rapidly grows and commonly spreads into nearby brain tissue. It is a devastating brain cancer that often results in death within approximately 12 to 15 months after diagnosis. In this work, optimal control theory was applied to regulate intracellular signaling pathways of miR-451-AMPK-mTOR-cell cycle dynamics via glucose and drug intravenous administration infusions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215547PLOS

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Stroke 2019 May;50(5):1232-1239

From the Division of Neuroscience and Experimental Psychology (E.L., J.B., G.C., S.M.A., D.B.), School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom.

Background and Purpose- A major process contributing to cell death in the ischemic brain is inflammation. Inflammasomes are multimolecular protein complexes that drive inflammation through activation of proinflammatory cytokines, such as IL (interleukin)-1β. Preclinical evidence suggests that IL-1β contributes to a worsening of ischemic brain injury. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023620DOI Listing

Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment.

J Interferon Cytokine Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.

Interleukin (IL)-27 is a promising anti-cancer cytokine with therapeutic potential. Exhibiting overlapping properties with type I and II interferons (IFNs), IL-27 impacts cancer cell viability and immune cell activity. Known to modulate toll-like receptor (TLR) expression, we investigated whether IL-27 affected TLR-mediated death in cancer cells. Read More

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https://www.liebertpub.com/doi/10.1089/jir.2018.0166
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http://dx.doi.org/10.1089/jir.2018.0166DOI Listing
April 2019
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Salinomycin-loaded gold nanoparticles for treating cancer stem cells by ferroptosis-induced cell death.

Mol Pharm 2019 Apr 22. Epub 2019 Apr 22.

Cancer Stem Cells (CSCs) are a subpopulation of tumor cells which exhibits self-renewal, differentiation and tumorigenicity. CSCs are highly resistant to conventional cancer treatment and have been associated with metastasis. Several studies have been shown that salinomycin (Sal) has the potential to target cancer stem cells and evidenced by in vitro and in vivo tumor models. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00132DOI Listing

Eudesmane Glycosides from Ambrosia artemisiifolia (Common Ragweed) as Potential Neuroprotective Agents.

J Nat Prod 2019 Apr 22. Epub 2019 Apr 22.

Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.

In Alzheimer's disease, amyloid-β (Aβ) accumulation in the brain results in neuronal cell death and is one of the major causes of dementia. Because the current therapeutic agents are not yet sufficiently effective or safe, there have been attempts to find new neuroprotective chemicals against Aβ-induced cytotoxicity. A 70% EtOH extract of whole plants of Ambrosia artemisiifolia (common ragweed) was selected after the screening of a natural extract library. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00841DOI Listing

Design, synthesis, and biological evaluation of lipophilically modified bisphenol Z derivatives.

Chem Biol Drug Des 2019 Apr 22. Epub 2019 Apr 22.

The University of Findlay, College of Pharmacy, 1000 North Main Street, Findlay, OH, 45840.

In the present study, a small library of bisphenol Z (BPZ) derivatives was synthesized and investigated for anti-proliferative effects in cultured breast and glioblastoma cell lines. Synthesized BPZ derivatives varied in molecular size, polarity, and lipophilicity. Of the 8 derivatives tested, compounds 4 and 6, both of which displayed the highest degree of lipophilicity, were most active at inducing cell death as determined by the XTT assay. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13531
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http://dx.doi.org/10.1111/cbdd.13531DOI Listing
April 2019
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Cholix toxin, an eEF2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.

Cell Microbiol 2019 Apr 22:e13033. Epub 2019 Apr 22.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Vibrio cholerae produced-Cholix toxin (Cholix) is a cytotoxin that ADP-ribosylates eukaryotic elongation factor 2, inhibiting protein synthesis, and inducing apoptosis. Here, we identified prohibitin (PHB) 1 and 2 as novel Cholix-interacting membrane proteins in immortalized human hepatocytes and HepG2 cells by Cholix immunoprecipitation assays. The expression level of PHB1 was decreased by Cholix after a 12 h incubation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13033
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http://dx.doi.org/10.1111/cmi.13033DOI Listing
April 2019
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Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response after Ethanol Feeding in Mice.

Alcohol Clin Exp Res 2019 Apr 22. Epub 2019 Apr 22.

Center for Liver Disease Research, Department of Inflammation and Immunity - Cleveland Clinic, Cleveland, OH, United States.

Introduction: Macrophage migration inhibitory factor (MIF), a pluripotent immune regulator, is an emerging mediator in Alcohol-related Liver Disease (ALD). MIF is associated with ALD progression through its chemokine- and cytokine-like activities.

Methods: Mechanistic studies into the role of MIF in ethanol-induced liver injury were performed in Mif mice and in C57BL/6J mice treated with a small molecule MIF antagonist, MIF098, after Gao-Binge (acute-on-chronic) ethanol feeding, an ethanol feeding protocol associated with hepatic neutrophilia and induction of the Unfolded Protein Response (UPR). Read More

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http://dx.doi.org/10.1111/acer.14065DOI Listing

α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson's disease model.

J Neurochem 2019 Apr 22. Epub 2019 Apr 22.

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil, 21941-902.

Parkinson's disease (PD) is characterized by selective death of dopaminergic neurons in the substantia nigra, degeneration of the nigrostriatal pathway, increases in glutamatergic synapses in the striatum and aggregation of α-synuclein. Evidence suggests that oligomeric species of α-synuclein (αSO) are the genuine neurotoxins of PD. Although several studies have supported the direct neurotoxic effects of αSO on neurons, their effects on astrocytes have not been directly addressed. Read More

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http://dx.doi.org/10.1111/jnc.14710DOI Listing

Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease.

JAMA Neurol 2019 Apr 22. Epub 2019 Apr 22.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

Importance: β-Amyloid deposits are a pathologic hallmark of Alzheimer disease (AD). However, the extent to which cortical β-amyloid protein in the absence of insoluble deposits is associated with classic features of AD appear to be unknown.

Objective: To examine the associations of cortical β-amyloid protein in the absence of insoluble deposits with cognitive decline, neurofibrillary tangles, other age-associated neuropathologic conditions, and APOE. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.0834DOI Listing

Opsonophagocytic Killing Assay to Assess Immunological Responses Against Bacterial Pathogens.

J Vis Exp 2019 Apr 5(146). Epub 2019 Apr 5.

Department of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia;

A key aspect of the immune response to bacterial colonization of the host is phagocytosis. An opsonophagocytic killing assay (OPKA) is an experimental procedure in which phagocytic cells are co-cultured with bacterial units. The immune cells will phagocytose and kill the bacterial cultures in a complement-dependent manner. Read More

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http://dx.doi.org/10.3791/59400DOI Listing

Severity stratification and prognostic prediction of patients with acute pancreatitis at early phase: A retrospective study.

Medicine (Baltimore) 2019 Apr;98(16):e15275

Department of Emergency Medicine, Beijing Chao-yang Hospital.

Severity stratification and prognostic prediction at early stage is crucial for reducing the rates of mortality of patients with acute pancreatitis (AP). We aim to investigate the predicting performance of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red-cell distribution width (RDW) combined with severity scores (sequential organ failure assessment [SOFA], bed-side index for severity of AP [BISAP], Ranson criteria, and acute physiology and chronic health evaluation II [APACHE II]) for severe AP (SAP) and mortality.A total of 406 patients diagnosed with AP admitted in a tertiary teaching hospital were enrolled. Read More

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http://dx.doi.org/10.1097/MD.0000000000015275DOI Listing

Role of programmed cell death ligand-1 expression on prognostic and overall survival of breast cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15201

Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China.

Background: Recently, the correlation of immunological checkpoint marker programmed cell death ligand-1 (PD-L1) and the prognosis of various cancers has been a research hotspot. The aim of this study is to examine the prognostic effect of PD-L1 in breast cancer.

Methods: PubMed, EMBASE, Web of Science, the Cochrane Library database were searched for eligible studies and additional hand-searching were reviewed as an augmentation. Read More

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http://dx.doi.org/10.1097/MD.0000000000015201DOI Listing

Predicting Cancer Cell Survival Based on Measurable Cell Characteristics.

Radiat Res 2019 Apr 22. Epub 2019 Apr 22.

a   Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Radiooncology - OncoRay, Dresden, Germany.

Variation in cellular characteristics may determine tumor response and, consequently, patient survival in radiation therapy. However, patient-specific prediction of cellular radiation response is currently unavailable for treatment planning. Thus, the importance of developing a novel approach based on clinically accessible parameters prior to treatment (e. Read More

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http://dx.doi.org/10.1667/RR15265.1DOI Listing

Expanding the Chemical Space of Withaferin A by Incorporating Silicon to Improve its Clinical Potential on Human Ovarian Carcinoma Cells.

J Med Chem 2019 Apr 22. Epub 2019 Apr 22.

Ovarian cancer represents the seventh most commonly diagnosed cancer worldwide. Herein, we report on the development of a withaferin A-silyl ether library with 30 analogues reported for the first time. Cytotoxicity assays on human epithelial ovarian carcinoma cisplatin-sensitive and -resistant cell lines identified eight analogues displaying nanomolar-potency (IC ranging from 1 to 32 nM), higher than the lead compound and reference drug. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00146DOI Listing

Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.

JCO Precis Oncol 2019 4;3. Epub 2019 Mar 4.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Microsatellite instability-high (MSI-H) colorectal carcinomas (CRCs) show high rates of response to immune checkpoint inhibitors (IOs). mutations and protein loss have been proposed as causes of resistance to IOs, yet they are enriched in MSI-H CRC. We aimed to characterize -mutant, IO-naive CRC. Read More

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http://dx.doi.org/10.1200/PO.18.00321DOI Listing

Pembrolizumab-induced bullous pemphigoid.

JAAD Case Rep 2019 Apr 5;5(4):362-364. Epub 2019 Apr 5.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453921PMC

Severe pulmonary toxicity from immune checkpoint inhibitor treated successfully with intravenous immunoglobulin: Case report and review of the literature.

Respir Med Case Rep 2019 6;27:100834. Epub 2019 Apr 6.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Immune checkpoint inhibitors are known to cause a variety of immune-related adverse events, including pneumonitis. When symptomatic, treatment typically consists of temporary or permanent cessation of the checkpoint inhibitor and several weeks of corticosteroid therapy. However, a subset of patients may suffer from severe pneumonitis, and the optimal treatment for this group is not known. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456450PMC

Tissue Destruction Caused by Parasite Cell Death, Inflammation, Invasion, and the Gut Microbiome.

Curr Clin Microbiol Rep 2019 21;6(1):51-57. Epub 2019 Jan 21.

1Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA USA.

Purpose Of Review: is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by

Recent Findings: Recent studies have identified new mechanisms involved in -induced tissue damage. Read More

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http://link.springer.com/10.1007/s40588-019-0113-6
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http://dx.doi.org/10.1007/s40588-019-0113-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449278PMC
January 2019
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Poorly differentiated adenocarcinoma of an unknown primary with a thyroid tumour and an aggressive course: thyroid or lung carcinoma?

Oxf Med Case Reports 2019 Apr 16;2019(4):omy129. Epub 2019 Apr 16.

Division of Internal Medicine, Department of Internal Medicine, Chitose City Hospital, Hokkaido 066-8550, Japan.

Cancers of unknown primary (CUPs) are challenging for physicians to diagnose and treat. Metastases to the thyroid gland are rare, representing less than 1% of all thyroid malignancies. Here, we report a case of a 69-year-old Asian man who had both thyroid gland and lymph node enlargement in the neck and shoulders but no nodules/tumours in the lung field. Read More

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http://dx.doi.org/10.1093/omcr/omy129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467094PMC

The immune checkpoint molecules PD-1, PD-L1, TIM-3 and LAG-3 in diffuse large B-cell lymphoma.

Oncotarget 2019 Mar 12;10(21):2030-2040. Epub 2019 Mar 12.

Division of Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

Signaling through immune checkpoint receptors may lead to T-cell exhaustion and function as immune escape mechanisms in cancer. For diffuse large B-cell lymphoma (DLBCL), the mechanistic and prognostic importance of these markers on tumor cells and the tumor microenvironment remains unclear. We determined the immunohistochemical expression of PD-1, PD-L1, TIM-3, and LAG-3 on tumor cells and on tumor infiltrating lymphocytes (TILs) among 123 DLBCL patients. Read More

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http://www.oncotarget.com/fulltext/26771
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http://dx.doi.org/10.18632/oncotarget.26771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459346PMC
March 2019
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Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy.

Oxid Med Cell Longev 2019 17;2019:1583656. Epub 2019 Mar 17.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Mitochondrial dysfunction has been implicated in a wide variety of degenerative diseases, including age-related macular degeneration. Damage to mitochondria and mitochondrial DNA accumulates with age in the postmitotic retinal pigment epithelium (RPE), which could lead to RPE cell death and trigger disease. One possible mechanism for cells to avoid cell death is mitophagy, the targeted clearance of damaged mitochondria by autophagy. Read More

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https://www.hindawi.com/journals/omcl/2019/1583656/
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http://dx.doi.org/10.1155/2019/1583656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441541PMC
March 2019
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A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin.

Cell Div 2019 10;14. Epub 2019 Apr 10.

1Department of Science, University of "Roma Tre", Rome, Italy.

Background: Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generation of new analogues with improved anticancer activity and better bioavailability. In the present study we investigated the anticancer activity of a novel trimethoxystilbene derivative (3,4,4'-trimethoxylstilbene), where two methoxyl groups are adjacent on the benzene ring (ortho configuration), and compared its activity to 3,5,4'-trimethoxylstilbene, whose methoxyl groups are in meta configuration. Read More

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http://dx.doi.org/10.1186/s13008-019-0046-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457039PMC

The role of photodynamic therapy on multidrug resistant breast cancer.

Cancer Cell Int 2019 11;19:91. Epub 2019 Apr 11.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, 2028 South Africa.

Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to treatment failure and development of drug resistance. In addition, abnormal signal transduction and dysfunctional DNA repair genes are common features with breast cancer resistance. Chemo-resistance of breast cancer associated with multidrug resistance events utilizes ATP-binding cassette (ABC) efflux transporters to decrease drug intracellular concentration. Read More

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http://dx.doi.org/10.1186/s12935-019-0815-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458738PMC

Microglia in the Neurovascular Unit: Blood-Brain Barrier-microglia Interactions After Central Nervous System Disorders.

Neuroscience 2019 May 6;405:55-67. Epub 2018 Jul 6.

Faculty of Biology, Medicine and Health, AV Hill Building, The University of Manchester, United Kingdom. Electronic address:

Over the past few decades, microglial cells have been regarded as the main executor of inflammation after acute and chronic central nervous system (CNS) disorders, responding rapidly to exogenous stimuli during acute trauma or infections, or signals released by cells undergoing cell death during conditions such as stroke, Alzheimer's disease (AD) and Parkinson's disease (PD). Barriers of the nervous system, and in particular the blood-brain barrier (BBB), play a key role in the normal physiological and cognitive functions of the brain. Being at the interface between the central and peripheral compartment, the BBB is regarded as a sensor of homeostasis, and any disruption within the brain or the systemic compartment triggers BBB dysfunction and neuroinflammation, both contributing to the pathogenesis of cerebrovascular disease. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.06.046DOI Listing

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.

Autophagy 2019 Apr 21:1-18. Epub 2019 Apr 21.

a State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD , School of Stomatology, the Fourth Military Medical University , Xi'an , China.

A switch from autophagy to apoptosis is implicated in chondrocytes during the osteoarthritis (OA) progression with currently unknown mechanism(s). In this study we utilized a flow fluid shear stress (FFSS) model in cultured chondrocytes and a unilateral anterior crossbite (UAC) animal model. We found that both FFSS and UAC actively induced endoplasmic reticulum stress (ERS) in the temporomandibular joints (TMJ) chondrocytes, as demonstrated by dramatic increases in expression of HSPA5, p-EIF2AK3, p-ERN1 and ATF6. Read More

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http://dx.doi.org/10.1080/15548627.2019.1606647DOI Listing

Focal adhesion kinase (FAK) phosphorylation is a key regulator of embryonal rhabdomyosarcoma (ERMS) cell viability and migration.

J Cancer Res Clin Oncol 2019 Apr 21. Epub 2019 Apr 21.

Department of Biochemistry and Molecular Biology, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.

Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. Pathogenesis of RMS is associated with aggressive growth pattern and increased risk of morbidity and mortality. There are two main subtypes or RMS: embryonal and alveolar. Read More

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http://dx.doi.org/10.1007/s00432-019-02913-3DOI Listing

Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.

Purpose: Curcumin (Cur), a yellow-colored dietary flavor from the plant (Curcuma longa), has been demonstrated to potentially resist diverse diseases, including ovarian cancer, but drug resistance becomes a major limitation of its success clinically. The key molecule or mechanism associated with curcumin resistance in ovarian cancer still remains unclear. The aim of our study was to investigate the effects of curcumin on autophagy in ovarian cancer cells and elucidate the underlying mechanism. Read More

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http://link.springer.com/10.1007/s00404-019-05058-3
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http://dx.doi.org/10.1007/s00404-019-05058-3DOI Listing
April 2019
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The Dlg Module and Clathrin-Mediated Endocytosis Regulate EGFR Signaling and Cyst Cell-Germline Coordination in the Drosophila Testis.

Stem Cell Reports 2019 Apr 5. Epub 2019 Apr 5.

Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.

Tissue homeostasis and repair relies on proper communication of stem cells and their differentiating daughters with the local tissue microenvironment. In the Drosophila male germline adult stem cell lineage, germ cells proliferate and progressively differentiate enclosed in supportive somatic cyst cells, forming a small organoid, the functional unit of differentiation. Here we show that cell polarity and vesicle trafficking influence signal transduction in cyst cells, with profound effects on the germ cells they enclose. Read More

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http://dx.doi.org/10.1016/j.stemcr.2019.03.008DOI Listing

Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

a Perinatology Research Branch , Division of Obstetrics and Maternal Fetal Medicine , Division of Intramural Research , Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health , U. S. Department of Health and Human Services , Bethesda , Maryland, and Detroit, Michigan, USA.

Objective: Pyroptosis is an inflammatory form of programed cell death that is mediated by the activation of the inflammasome and depends on the pore-forming function of gasdermin D. Therefore, the detection of gasdermin D represents in vivo evidence of pyroptosis. We recently showed that there is intra-amniotic inflammasome activation in spontaneous labor at term; however, evidence of pyroptosis is lacking. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610740DOI Listing

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.

FEBS Open Bio 2019 Apr 1. Epub 2019 Apr 1.

Department of Biomedical Experimental and Clinical Sciences 'Mario Serio', University of Florence, Italy.

Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes are the main regulators of bone remodelling. For the first time, we demonstrate here that blueberry juice (BJ), obtained from Vaccinium myrtillus, rich in polyphenols, shows antioxidant and antiosteoclastogenic properties in MLO-Y4 osteocytes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/2211-5463.12
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http://dx.doi.org/10.1002/2211-5463.12634DOI Listing
April 2019
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A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer.

Breast Cancer Res Treat 2019 Apr 20. Epub 2019 Apr 20.

Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA.

Purpose: Primary breast and prostate cancers can be cured, but metastatic disease cannot. Identifying cell factors that predict metastatic potential could guide both prognosis and treatment.

Methods: We used Cell-SELEX to screen an RNA aptamer library for differential binding to prostate cancer cell lines with high vs. Read More

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http://link.springer.com/10.1007/s10549-019-05174-3
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http://dx.doi.org/10.1007/s10549-019-05174-3DOI Listing
April 2019
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M51R and Delta-M51 matrix protein of the vesicular stomatitis virus induce apoptosis in colorectal cancer cells.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

Cell and Molecular Research center, Golestan University of Medical Science, 1 Shastcola Ave, 5 km Sari Rd, Gorgan, Iran.

Colorectal cancer (CRC) is the third most common cancer in both men and women. Oncolytic viral-based therapy methods seem to be promising for CRC treatment. Vesicular stomatitis virus (VSV) is considered as a potent candidate in viral therapy for several tumors. Read More

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http://dx.doi.org/10.1007/s11033-019-04799-3DOI Listing

The Dual Role of HIV-1 gp120 V3 Loop-Induced Autophagy in the Survival and Apoptosis of the Primary Rat Hippocampal Neurons.

Neurochem Res 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathophysiology, Key Laboratory of the State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong Province, China.

HIV-1 gp120, an important subunit of the envelope spikes that decorate the surface of virions, is known to play a vital role in neuronal injury during HIV-1-associated neurocognitive disorder (HAND), although the pathological mechanism is not fully understood. Our previous studies have suggested that the V3 loop of HIV-1 gp120 (HIV-1 gp120 V3 loop) can induce neuronal apoptosis in the hippocampus, resulting in impairment in spatial learning and memory in Sprague-Dawley (SD) rats. In this study, we demonstrated that autophagy was significantly increased in rat primary hippocampal neurons in response to treatment of HIV-1 gp120 V3 loop. Read More

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http://dx.doi.org/10.1007/s11064-019-02788-3DOI Listing

Selective vulnerability in α-synucleinopathies.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Movement and Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy are neurodegenerative disorders resulting in progressive motor/cognitive deficits among other symptoms. They are characterised by stereotypical brain cell loss accompanied by the formation of proteinaceous aggregations of the protein α-synuclein (α-syn), being, therefore, termed α-synucleinopathies. Although the presence of α-syn inclusions is a common hallmark of these disorders, the exact nature of the deposited protein is specific to each disease. Read More

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http://link.springer.com/10.1007/s00401-019-02010-2
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http://dx.doi.org/10.1007/s00401-019-02010-2DOI Listing
April 2019
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Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway.

Med Sci Monit 2019 Apr 21;25:2943-2949. Epub 2019 Apr 21.

Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).

BACKGROUND Pancreatic cancer is a major cause of mortality worldwide. Inefficient drugs, their adverse effects, and the development of drug resistance make it difficult to curb the growing incidence of pancreatic cancer. Against this backdrop, the development new drug regimens with no or negligible adverse effects is imperative. Read More

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https://www.medscimonit.com/abstract/index/idArt/914244
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http://dx.doi.org/10.12659/MSM.914244DOI Listing
April 2019
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Ethanolic extract of Kaempferia parviflora interrupts the mechanisms-associated rheumatoid arthritis in SW982 culture model via p38/STAT1 and STAT3 pathways.

Phytomedicine 2018 Nov 14;59:152755. Epub 2018 Nov 14.

Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Background: Kaempferia parviflora Wall. ex Baker (KP) has long been used in traditional medicine to treat various diseases because active compounds in rhizome extracts are important anti-inflammatory agents.

Purpose: This study aims to investigate the effects of an ethanolic extract of KP on the molecular mechanisms associated with rheumatoid arthritis (RA), which was induced by a combination of proinflammatory cytokines (IL-1β or TNF-α with IL-17A) in a human synovial sarcoma cell line (SW982) culture model. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.015DOI Listing
November 2018

DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.

Phytomedicine 2018 Dec 2;59:152778. Epub 2018 Dec 2.

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China. Electronic address:

Background: Metastasis is the main cause of death in breast cancer and previous researches have indicated the pivotal role of adipocytes in breast cancer metastasis. DT-13, the saponin monomer 13 of the Dwarf lilyturf tuber, has been proved to exert potential anti-metastatic effect, the detailed mechanisms have not been well elucidated and the role of DT-13 in modulating adipocyte-breast cancer microenvironment has been given little attention.

Purpose: This study aims to explore the mechanisms of DT-13 in inhibiting breast cancer metastasis and whether DT-13 inhibit breast cancer metastasis via modulating the interactions between adipocytes and breast cancer cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183059
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http://dx.doi.org/10.1016/j.phymed.2018.12.001DOI Listing
December 2018
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Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines.

Phytomedicine 2018 Nov 22;58:152770. Epub 2018 Nov 22.

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, 80708 Kaohsiung, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; PhD Program in Translational Medicine, College of Medicine and PhD Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, 80708 Kaohsiung, Taiwan; Department of Medical Research Center and Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan. Electronic address:

Background: Phenanthrenes isolated from Juncus species possess different biological activities, including antiproliferative and antimigratory effects.

Purpose: In this study, nine phenanthrenes isolated from the roots of Juncus inflexus were investigated for their antiproliferative activity on several gynecological cancer cell lines, using non-cancerous cells as controls.

Methods: Antiproliferative activities of the compounds were determined by means of MTT assay. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.030DOI Listing
November 2018

Hippocampus and basal ganglia as potential sentinel sites for ischemic pathology after resuscitated cardiac arrest.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Department of Clinical Sciences, Division of Pathology and Oncology, Lund University, Sweden.

Aims Of The Study: Neurological impairment after resuscitated cardiac arrest (CA) remains a significant unmet medical need. Brain ischemia associated with CA and subsequent reperfusion is evident as two fundamentally different types of damage on neuropathological examination: frank necrosis (involving all cell types) and selective eosinophilic neuronal death (SEND). These types of damage are not only dissimilar in micromorphology, but also differently detectable with clinical brain imaging methods. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.012DOI Listing

Heterogeneous Expression of Programmed Death Receptor-ligand 1 on Circulating Tumor Cells in Patients With Lung Cancer.

Clin Lung Cancer 2019 Mar 25. Epub 2019 Mar 25.

Internal Medicine III, Wakayama Medical University, Wakayama, Japan.

Background: Blockade of the programmed death receptor-1 (PD-1) pathway is effective against solid tumors including lung cancer. PD-ligand 1 (PD-L1) expression on tumor tissue serves as a predictive biomarker for the efficacy of PD-1 pathway blockade. Here, we evaluated the expression of PD-L1 on circulating tumor cells (CTCs) in patients with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15257304193007
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http://dx.doi.org/10.1016/j.cllc.2019.03.004DOI Listing
March 2019
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Incidence of thyroid dysfunctions during treatment with nivolumab for non-small cell lung cancer: Retrospective study of 105 patients.

Presse Med 2019 Apr 17. Epub 2019 Apr 17.

CHU Larrey, Department of endocrinology and metabolic diseases, 31059 Toulouse, France. Electronic address:

Introduction: Immunotherapy is a standard not only in second line but also in first line treatment in patients with non-small cell lung cancer (NSCLC) and other tumors. Thyroid dysfunctions are the most common endocrine toxicities.

Objective: To determine the incidence of thyroid dysfunctions during treatment with a PD-1 monoclonal antibody (nivolumab) in patients with NSCLC. Read More

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http://dx.doi.org/10.1016/j.lpm.2018.10.019DOI Listing

PD-1/PD-L1 Combinations in Advanced Urothelial Cancer: Rationale and Current Clinical Trials.

Clin Genitourin Cancer 2019 Mar 29. Epub 2019 Mar 29.

New York University Perlmutter Cancer Center, New York, NY.

Chemotherapy is no longer the only viable option for patients with locally advanced or metastatic urothelial carcinoma. Immunotherapy, as checkpoint inhibition, has received United States Food and Drug Administration approval in the preceding several years, both in the second-line and first-line for cisplatin-ineligible patients. Those who respond often do so durably; however, response rates in the first line are 23% to 24%, and are lower in the second line. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.03.009DOI Listing
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