493,855 results match your criteria Cell Death & Disease [Journal]


Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):704-711

Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States.

Purpose: While VZV DNA and antigen have been detected in acute and chronic VZV keratitis, it is unclear whether productive infection of corneal cells is ongoing or whether residual, noninfectious VZV antigens elicit inflammation. Herein, we examined VZV-infected primary human corneal epithelial cells (HCECs) and keratocytes (HKs) to elucidate the pathogenesis of VZV keratitis.

Methods: HCECs and HKs were mock- or VZV infected. Read More

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http://dx.doi.org/10.1167/iovs.18-25801DOI Listing
February 2019

Is it true that gut microbiota is considered as panacea in cancer therapy?

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran.

Recent studies demonstrated that a combination of the gut microbiome has the vital effect on the efficacy of anticancer immune therapies. Regulatory effects of microbiota have been shown in different types of cancer therapies such as chemotherapy and immunotherapy. Immune-checkpoint-blocked therapies are the recent efficient cancer immunotherapy strategies. Read More

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http://dx.doi.org/10.1002/jcp.28333DOI Listing
February 2019

First-Line Nivolumab Plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers.

J Clin Oncol 2019 Feb 20:JCO1801042. Epub 2019 Feb 20.

21 Winship Cancer Institute, Emory University, Atlanta, GA.

Purpose: CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment of advanced/metastatic non-small-cell lung cancer (NSCLC). We assessed the association of efficacy with programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB).

Patients And Methods: Two hundred eighty-eight patients with previously untreated, recurrent stage IIIB/IV NSCLC received nivolumab 3 mg/kg every 2 weeks plus ipilimumab 1 mg/kg every 6 weeks. Read More

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http://dx.doi.org/10.1200/JCO.18.01042DOI Listing
February 2019

Glucose causes primary necrosis in exponentially grown yeast saccharomyces cerevisiae.

FEMS Yeast Res 2019 Feb 20. Epub 2019 Feb 20.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, FRC PCBR RAS.

In this paper we present data on sugar-induced cell death (SICD) in the yeast S.cerevisiae in the exponential phase of growth. We suggest that the nature of SICD in exponentially grown yeast is primary necrosis, in contrast to cells in the stationary growth phase, which exhibit apoptotic SICD. Read More

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http://dx.doi.org/10.1093/femsyr/foz019DOI Listing
February 2019

Interplay between miRNAs and host genes and their role in cancer.

Brief Funct Genomics 2019 Feb 20. Epub 2019 Feb 20.

Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Read More

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https://academic.oup.com/bfg/advance-article/doi/10.1093/bfg
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http://dx.doi.org/10.1093/bfgp/elz002DOI Listing
February 2019
1 Read

Induction of Apoptosis in HeLa by Corn Small RNAs.

Nutr Cancer 2019 Feb 20:1-11. Epub 2019 Feb 20.

a Cancer and Translational Research Lab, Dr D. Y. Patil Biotechnology & Bioinformatics Institute, Dr D.Y. Patil Vidyapeeth , Pune , India.

Insights in RNA biology have opened up a plethora of opportunities to explore the small regulatory RNAs from various natural and artificial sources. These small RNAs have been suggested to play a role too in tumor progression by either as oncogenic or tumor suppressor small RNAs. In this study, authors have attempted to evaluate the therapeutic potential of small RNAs fractionated from corn (Zea mays) upon growth and survival of HeLa. Read More

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https://www.tandfonline.com/doi/full/10.1080/01635581.2018.1
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http://dx.doi.org/10.1080/01635581.2018.1526307DOI Listing
February 2019
1 Read

mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors.

Drug Deliv 2018 Nov;25(1):1790-1801

a CRAN, CNRS UMR 7039 , Université de Lorraine , Nancy , France.

Efficient photodynamic therapy with meta-tetra(hydroxyphenyl)chlorine requires the application of specific nanoformulations. mTHPC liposomal formulation (Foslip) demonstrated favorable pharmacokinetics properties. However, rapid liposomes destruction in circulation and rapid mTHPC release impedes Foslip applications. Read More

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http://dx.doi.org/10.1080/10717544.2018.1513609DOI Listing
November 2018

The therapeutic effects of nicotinamide in hepatocellular carcinoma through blocking IGF-1 and effecting the balance between Nrf2 and PKB.

Biomed Pharmacother 2019 Feb 19;112:108653. Epub 2019 Feb 19.

Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Insulin growth factor (IGF) family and their receptors play a great role in tumors' development. In addition, IGF-1 enhances cancer progression through regulating cell proliferation, angiogenesis, immune modulation and metastasis. Moreover, nicotinamide is association with protection against cancer. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108653DOI Listing
February 2019

Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.

Biomed Pharmacother 2019 Feb 18;112:108602. Epub 2019 Feb 18.

Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China; Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China. Electronic address:

Cervical cancer remains one of the main factors leading to tumor-related death worldwide. Many strategies of cancer treatment such as chemotherapy are developed and used nowadays. However, for the cancer chemotherapy resistance, reduction of the limitation of cancer chemotherapy efficacy is one of the aims of several oncology teams. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108602DOI Listing
February 2019

Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis.

Biomed Pharmacother 2019 Feb 20;112:108607. Epub 2019 Feb 20.

Integrative Research Laboratory of Breast Cancer, Discipline of Integrated Chinese and Western Medicine, the Research Center of Integrative Medicine, School of Basic Medical Sciences & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China; Post-doctoral Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

Background: Breast cancer remains the most common female malignancy and metastasis is the leading cause of death in breast cancer patients. Oldenlandia diffusa has been empirically and extensively used as an adjuvant therapy for metastatic breast cancer patients in Traditional Chinese Medicine (TCM) with proven efficacy. However, its anti-metastasis mechanism has been poorly revealed. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108607DOI Listing
February 2019

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death.

Biomed Pharmacother 2019 Feb 18;112:108586. Epub 2019 Feb 18.

Biotechnology Institute, Federal University of Uberlândia, MG, Brazil. Electronic address:

This work reports the biological evaluation of a copper complex of the type [Cu(O-O)(N-N)ClO], in which O-O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N-N = 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic effect of CBP-01 was evaluated by resazurin assay and cell proliferation was determined by MTT assay. DNA fragmentation was analyzed by gel electrophoresis. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.047DOI Listing
February 2019

cRGD target liposome delivery system promoted immunogenic cell death through enhanced anticancer potency of a thymidine conjugate under UVA activation as a cancer vaccine.

Eur J Med Chem 2019 Feb 13;167:499-509. Epub 2019 Feb 13.

Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. Electronic address:

Conventional chemotherapeutic and photodynamic therapy have recently been shown to also elicit immune response against cancer through the immunogenic cell death mechanism, which can be potentially translated into effective cancer vaccines. However, there are few studies on the potential of nanodelivery system to promote the immunogenic cell death as a cancer vaccine. We reported here that cRGD target liposome delivery system was capable to promote the immunogenic cell death through enhanced potency of a thymidine conjugate post UVA activation as a cancer vaccine. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.031DOI Listing
February 2019

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo.

Eur J Med Chem 2019 Feb 13;167:377-387. Epub 2019 Feb 13.

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address:

The great interest in epithelial-to-mesenchymal transition (EMT) programme lies in its association with process of metastasis and invasion, which is a crucial cause of cancer-related death. Herein, we designed and reported three new NSAID-Pt(IV) prodrugs, taking Non-Steroid Anti-Inflammatory Drugs (NSAIDs) to disrupt EMT programme and assist genotoxic platinum-based drugs as a cytotoxicity booster, to offer a class of potential anticarcinogens with a multi-functional action mechanism. The NSAID-Pt(IV) prodrugs, especially Eto-Pt(IV), highly enhanced cellular uptake with amount up to 42-fold at 3 h compared with CDDP, and greatly increased DNA damage and cell apoptosis, showing much higher cytotoxicity than cisplatin in the tested cancer cells even in A549/cis cells. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.041DOI Listing
February 2019

Modulation of antiviral immunity by the ichnovirus HdIV in Spodoptera frugiperda.

Mol Immunol 2019 Feb 20;108:89-101. Epub 2019 Feb 20.

UMR 1333 INRA - Université de Montpellier Diversité, Génomes & Interactions Microorganismes-Insectes (DGIMI), 34095 Montpellier, France. Electronic address:

Polydnaviruses (PDVs) are obligatory symbionts found in thousands of endoparasitoid species and essential for successful parasitism. The two genera of PDVs, ichnovirus (IV) and bracovirus (BV), use different sets of virulence factors to ensure successful parasitization of the host. Previous studies have shown that PDVs target apoptosis, one of the innate antiviral responses in many host organisms. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.02.011DOI Listing
February 2019

Live or Let Die: T Cell Survival in Cancer Immunotherapy.

Immunity 2019 Feb;50(2):280-282

Laboratory of Experimental Dermatology, Department of Dermatology, Otto-von-Guericke University, Magdeburg, Germany. Electronic address:

Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) show that, in the setting of low tumor burden, this combination regimen promotes interferon-γ-dependent T cell hyperactivation and death and thus favors tumor progression. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.016DOI Listing
February 2019

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

SLAS Discov 2019 Mar;24(3):346-361

3 Fraunhofer Institute for Molecular Biology and Applied Ecology-ScreeningPort, Hamburg, Germany.

According to the World Health Organization, more than 1 billion people are at risk of or are affected by neglected tropical diseases. Examples of such diseases include trypanosomiasis, which causes sleeping sickness; leishmaniasis; and Chagas disease, all of which are prevalent in Africa, South America, and India. Our aim within the New Medicines for Trypanosomatidic Infections project was to use (1) synthetic and natural product libraries, (2) screening, and (3) a preclinical absorption, distribution, metabolism, and excretion-toxicity (ADME-Tox) profiling platform to identify compounds that can enter the trypanosomatidic drug discovery value chain. Read More

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http://dx.doi.org/10.1177/2472555218823171DOI Listing

LncRNA SNHG16 promotes cell proliferation through miR-302a-3p/FGF19 axis in hepatocellular carcinoma.

Neoplasma 2019 Feb 20. Epub 2019 Feb 20.

Hepatocellular carcinoma (HCC) is the sixth common malignancies worldwide and the leading cause of death in Asian and African countries. Aberrant accumulation of lncRNAs is one of major causes of tumorigenesis in HCC. Small nucleolar RNA host gene 16 (SNHG16) is identified as an oncogene in multiple types of tumor. Read More

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http://dx.doi.org/10.4149/neo_2018_180720N504DOI Listing
February 2019

Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells.

J Appl Toxicol 2019 Feb 19. Epub 2019 Feb 19.

Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, USA.

Graphene-based nanomaterials hold the potential to be used in a wide variety of applications, including biomedical devices. Pristine graphene (PG) is an un-functionalized, defect-free type of graphene that could be used as a material for neural interfacing. However, the neurotoxic effects of PG, particularly to the blood-brain barrier (BBB), have not been fully studied. Read More

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http://dx.doi.org/10.1002/jat.3786DOI Listing
February 2019

PD-1/PD-L1 pathway: Basic biology and role in cancer immunotherapy.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Over the course of past few years, cancer immunotherapy has been accompanied with promising results. However, preliminary investigations with respect to immunotherapy concentrated mostly on targeting the immune checkpoints, nowadays, emerge as the most efficient strategy to raise beneficial antitumor immune responses. Programmed cell death protein 1 (PD-1) plays an important role in subsiding immune responses and promoting self-tolerance through suppressing the activity of T cells and promoting differentiation of regulatory T cells. Read More

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http://dx.doi.org/10.1002/jcp.28358DOI Listing
February 2019

Metformin protects PC12 cells and hippocampal neurons from H O -induced oxidative damage through activation of AMPK pathway.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China.

Metformin, a first line anti type 2 diabetes drug, has recently been shown to extend lifespan in various species, and therefore, became the first antiaging drug in clinical trial. Oxidative stress due to excess reactive oxygen species (ROS) is considered to be an important factor in aging and related disease, such as Alzheimer's disease (AD). However, the antioxidative effects of metformin and its underlying mechanisms in neuronal cells is not known. Read More

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http://dx.doi.org/10.1002/jcp.28337DOI Listing
February 2019

EGFR-targeted therapy alters the tumor microenvironment in EGFR-driven lung tumors: Implications for combination therapies.

Int J Cancer 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China.

Immune checkpoint inhibitors targeting the programmed cell death receptor/ligand 1 (PD-1/PD-L1) pathway have profoundly improved the clinical management of non-small-cell lung cancer (NSCLC). Nevertheless, the superiority of single-agent PD-1/PD-L1 inhibitors in pretreated EGFR mutant patients has turned out to be moderate. One proposed mechanism for poor response to immune checkpoint inhibitors is an immunosuppressive tumor microenvironment. Read More

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http://dx.doi.org/10.1002/ijc.32191DOI Listing
February 2019

Immune Checkpoint Inhibitors and Beyond: An Overview of Immune-Based Therapies in Merkel Cell Carcinoma.

Authors:
Mahtab Samimi

Am J Clin Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Dermatology Department, University Hospital of Tours, Avenue de la République, 37170, Chambray-les-Tours, France.

Merkel cell carcinoma (MCC) is an aggressive skin cancer. Until 2017, patients with advanced disease were typically treated with conventional chemotherapies, with a median response duration of 3 months. Increased evidence of the role of the immune system in controlling this cancer has paved the way for immune-based therapies, with programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitors at the frontline. Read More

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http://dx.doi.org/10.1007/s40257-019-00427-9DOI Listing
February 2019

Involvement of Actin Filaments in the Cytotoxic Effect of GD2-Specific Antibodies.

Bull Exp Biol Med 2019 Feb 19. Epub 2019 Feb 19.

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk neuroblastoma. The mechanisms of the cytotoxic signal triggered by antibody binding to GD2 ganglioside on the surface of the tumor cell remain insufficiently studied. Using inhibitor analysis we demonstrated that actin microfilaments are involved in the cell death induced by GD2-specific antibodies. Read More

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http://dx.doi.org/10.1007/s10517-019-04389-0DOI Listing
February 2019

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

EJNMMI Res 2019 Feb 19;9(1):18. Epub 2019 Feb 19.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

Purpose: We have previously developed the caspase-based radiotracer, F-ICMT-11, for PET imaging to monitor treatment response. We further validated F-ICMT-11 specificity in a murine melanoma death-switch tumour model with conditional activation of caspase-3 induced by doxycycline.

Methods: Caspase-3/7 activity and cellular uptake of F-ICMT-11, F-ML-10 and F-FDG were assessed in B16ova and B16ovaRevC3 cells after death-switch induction. Read More

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http://dx.doi.org/10.1186/s13550-019-0487-8DOI Listing
February 2019

Protein S-nitrosylation in programmed cell death in plants.

Cell Mol Life Sci 2019 Feb 19. Epub 2019 Feb 19.

College of Horticulture, Gansu Agricultural University, Lanzhou, People's Republic of China.

Programmed cell death (PCD) is associated with different phases of plant life and provides resistance to different kinds of biotic or abiotic stress. The redox molecule nitric oxide (NO) is usually produced during the stress response and exerts dual effects on PCD regulation. S-nitrosylation, which NO attaches to the cysteine thiol of proteins, is a vital posttranslational modification and is considered as an essential way for NO to regulate cellular redox signaling. Read More

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http://dx.doi.org/10.1007/s00018-019-03045-0DOI Listing
February 2019

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 15.

Burke Neurological Institute, White Plains, New York 10605.

Ferroptotic death is a mechanism for tumor suppression by pharmacological inhibitors that target the X transporter (cystine/glutamate antiporter) in a host of non-CNS and CNS tumors. Inhibition of this transporter leads to reduction of cystine uptake, cyst(e)ine deprivation, subsequent depletion of the versatile antioxidant glutathione, and reactive lipid species-dependent death. Accordingly, pharmacological inhibitors of the X transporter can also induce neuronal cell death raising concerns about toxicity in the CNS and PNS if these agents are used for chemotherapy. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0263-18.2019
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http://dx.doi.org/10.1523/ENEURO.0263-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378329PMC
February 2019
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Targeted human cytolytic fusion proteins at the cutting edge: harnessing the apoptosis-inducing properties of human enzymes for the selective elimination of tumor cells.

Oncotarget 2019 Jan 25;10(8):897-915. Epub 2019 Jan 25.

Medical Biotechnology and Immunotherapy Unit, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7700, South Africa.

Patient-specific targeted therapy represents the holy grail of anti-cancer therapeutics, allowing potent tumor depletion without detrimental off-target toxicities. Disease-specific monoclonal antibodies have been employed to bind to oncogenic cell-surface receptors, representing the earliest form of immunotherapy. Targeted drug delivery was first achieved by means of antibody-drug conjugates, which exploit the differential expression of tumor-associated antigens as a guiding mechanism for the specific delivery of chemically-conjugated chemotherapeutic agents to diseased target cells. Read More

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http://dx.doi.org/10.18632/oncotarget.26618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368230PMC
January 2019

Enhanced phosphatidylserine-selective cancer therapy with irradiation and SapC-DOPS nanovesicles.

Oncotarget 2019 Jan 25;10(8):856-868. Epub 2019 Jan 25.

Division of Hematology/Oncology, Translational Research Laboratory, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Normal living cells exhibit phosphatidylserine (PS) primarily within the intracellular leaflet of the plasma membrane. In contrast, viable cancer cells have high levels of PS on the external surface, and exhibit a broad range of surface PS, even within specific types of cancer. Agents that target surface PS have recently been developed to treat tumors and are expected to be more effective with higher surface PS levels. Read More

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http://dx.doi.org/10.18632/oncotarget.26615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368238PMC
January 2019

Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells.

Oncotarget 2019 Jan 25;10(8):825-846. Epub 2019 Jan 25.

Center for Radiological Research, Department of Radiation Oncology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance radiosensitivity of GBM but not normal astrocytes. Inhibition of ATM kinase is an alternative mechanism for radiosensitization of cancer cells. Read More

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http://dx.doi.org/10.18632/oncotarget.26582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368233PMC
January 2019

3D culture enhances chemoresistance of ALL Jurkat cell line by increasing DDR1 expression.

Exp Ther Med 2019 Mar 4;17(3):1593-1600. Epub 2019 Jan 4.

Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266555, P.R. China.

Three dimensional (3D) culture has gradually become a research hotspot in the field of drug screening, stem cell research, and tissue engineering due to its more physiological-like morphology and function. In this study, we compared the differences of cell proliferation, population, protein expression and chemoresistance profiles between two dimensional (2D) and 3D culture of acute lymphoblastic leukemia (ALL) Jurkat cell line. Polycaprolactone (PCL) is used for 3D culture owing to its biochemical properties and compatibility. Read More

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http://dx.doi.org/10.3892/etm.2019.7153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364197PMC

microRNA-196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1.

Authors:
Junan Hu Wei Shen

Exp Ther Med 2019 Mar 4;17(3):1579-1586. Epub 2019 Jan 4.

Department of Neurosurgery, Beilun District People's Hospital of Ningbo City, Ningbo, Zhejiang 315800, P.R. China.

Dysfunction of the microRNA (miR) network has been indicated as a major regulator in neurological diseases. However, there is limited understanding regarding the functional significance of miRs in ischemic brain injury. In the present study, miR-196a expression was significantly increased in rat brains and neurons following transient middle cerebral artery occlusion (MCAO) or oxygen-glucose deprivation, respectively. Read More

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http://dx.doi.org/10.3892/etm.2019.7152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364231PMC

Anti-dengue activity of extracts and quantification of dengue viral inhibition by SYBR green reverse transcription polymerase chain reaction.

Ayu 2018 Apr-Jun;39(2):87-91

Department of Virology, King Institute of Preventive Medicine and Research, Chennai, Tamil Nadu, India.

Background: Dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. Read More

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http://www.ayujournal.org/text.asp?2018/39/2/87/250773
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http://dx.doi.org/10.4103/ayu.AYU_144_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369606PMC
February 2019
1 Read

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Sci Rep 2019 Feb 19;9(1):2314. Epub 2019 Feb 19.

Stem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Irreversible photoreceptor cell death is a major cause of blindness in many retinal dystrophies. A better understanding of the molecular mechanisms underlying the progressive loss of photoreceptor cells remains therefore crucial. Abnormal expression of microRNAs (miRNAs) has been linked with the aetiology of a number of retinal dystrophies. Read More

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http://dx.doi.org/10.1038/s41598-018-38294-9DOI Listing
February 2019

Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice.

Int J Oral Sci 2019 Feb 20;11(1). Epub 2019 Feb 20.

Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, China.

The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Read More

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http://dx.doi.org/10.1038/s41368-018-0040-zDOI Listing
February 2019

Reverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma.

Blood Cancer J 2019 Feb 19;9(3):22. Epub 2019 Feb 19.

Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Treatment with programmed death-1 (PD-1) blocking antibodies results in high overall response rates in refractory and relapsed classical Hodgkin lymphoma (cHL) patients, indicating that PD-1/PD-1 ligand interactions are integral to progression of this disease. Given the genetically driven increased PD-L1/2 expression in HL, we hypothesized that reverse signaling through PD-1 ligands may be a potential mechanism contributing to the growth and survival of Hodgkin Reed-Sternberg (HRS) cells in cHL. Our data show that engagement of PD-L1 using an agonistic monoclonal antibody increases cell survival and proliferation and reduces apoptosis in HL cell lines. Read More

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http://dx.doi.org/10.1038/s41408-019-0185-9DOI Listing
February 2019

Structure of SPH (Self-Incompatibility Protein Homologue) proteins, a widespread family of small, highly stable, secreted  proteins.

Biochem J 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, University of Oxford, Oxford, United Kingdom

SPH proteins are a large family of small, disulphide-bonded, secreted proteins, initially found in the self-incompatibility response in the field poppy , but now known to be widely distributed in plants, many containing multiple members of this protein family. Using the Origami strain of , we expressed one member of this family, SPH15 from , as a folded thioredoxin-fusion protein and purified it from the cytosol. The fusion protein was cleaved and characterised by analytical ultracentrifugation, circular dichroism, and NMR spectroscopy. Read More

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http://dx.doi.org/10.1042/BCJ20180828DOI Listing
February 2019

Proteolytic processing of SERK3/BAK1 regulates plant immunity, development and cell death.

Plant Physiol 2019 Feb 19. Epub 2019 Feb 19.

Texas A&M University CITY: college station STATE: Texas POSTAL_CODE: 77843 United States Of America [US]

Plants have evolved many receptor-like kinases (RLKs) to sense extrinsic and intrinsic cues. The signaling pathways mediated by multiple leucine-rich repeat (LRR) RLK (LRR-RLK) receptors require ligand-induced receptor-coreceptor heterodimerization and transphosphorylation with BAK1/SERK family LRR-RLKs. Here we reveal an additional layer of regulation of BAK1 via a Ca2+-dependent proteolytic cleavage process that is conserved in Arabidopsis thaliana, Nicotiana benthamiana and Saccharomyces cerevisiae . Read More

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http://dx.doi.org/10.1104/pp.18.01503DOI Listing
February 2019

AVR2 targets BSL family members, which act as susceptibility factors to suppress host immunity.

Plant Physiol 2019 Feb 19. Epub 2019 Feb 19.

University of Dundee CITY: Dundee POSTAL_CODE: DD2 5DA United Kingdom [GB]

To be successful plant pathogens, microbes use "effector proteins" to manipulate host functions to their benefit. Identifying host targets of effector proteins and characterizing their role in the infection process allow us to better understand plant-pathogen interactions and the plant immune system. Yeast two-hybrid and coimmunoprecipitation were used to demonstrate that the Phytophthora infestans effector PiAVR2 interacts with all three BSU1-like (BSL) family members from potato (Solanum tuberosum). Read More

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http://dx.doi.org/10.1104/pp.18.01143DOI Listing
February 2019

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells.

J Biol Chem 2019 Feb 19. Epub 2019 Feb 19.

Sichuan University, China.

Growth arrest and DNA damage-inducible gene 34 (GADD34) plays a critical role in responses to DNA damage and endoplasmic reticulum stress. GADD34 has opposing effects on different stimuli-induced cell apoptosis events, but the reason for this is unclear. Here, using immunoblotting analyses and various molecular genetic approaches in HepG2 and SMMC-7721 cells, we report that GADD34 protect hepatocellular carcinoma (HCC) cells from TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by stabilizing a BCL-2 family member, myeloid cell leukemia 1 (MCL-1). Read More

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http://dx.doi.org/10.1074/jbc.RA118.006029DOI Listing
February 2019

Necrotic cell debris induces a NF-κB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC).

Biochem Biophys Res Commun 2019 Feb 16. Epub 2019 Feb 16.

Universitaetsklinik Heidelberg, Department of Vascular and Endovascular Surgery, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Electronic address:

Abdominal aortic aneurysm (AAA) is a multi-factorial progressive vascular disease with life-threatening complications. Increasing evidence suggests that smooth muscle cell (SMC) dysfunction and cell death contribute to dilatation and rupture of the aorta by inducing an inflammatory response. The exact mechanism of this response however, is incompletely understood. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.051DOI Listing
February 2019

Tolling of a Bell at a Neuron's Death.

Dev Cell 2019 Feb;48(4):427-428

Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

Clearance of cellular debris is a process required to maintain tissue homeostasis. In this issue of Developmental Cell,McLaughlin et al. (2019) demonstrate that neuronal apoptosis non-autonomously activates the non-canonical Toll-like receptor signaling in cortex glia, priming their capacity to engulf apoptotic neurons and regulating maintenance of a healthy brain. Read More

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http://dx.doi.org/10.1016/j.devcel.2019.02.009DOI Listing
February 2019

Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.

Lancet 2019 Feb 14;393(10172):664-677. Epub 2019 Feb 14.

Anaesthesia and Pain Management Research Group, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia and Pain Management, The Royal Children's Hospital, Melbourne, VIC, Australia. Electronic address:

Background: In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have found no evidence for an association. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32485-1DOI Listing
February 2019

Late-onset isolated adrenocorticotropic hormone deficiency caused by nivolumab: a case report.

BMC Endocr Disord 2019 Feb 19;19(1):25. Epub 2019 Feb 19.

Internal Medicine 1, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: Immune checkpoint inhibitors including nivolumab, an anti-programmed cell death protein 1 antibody, are recently developed cancer immunotherapy agents. Immune checkpoint inhibitors are known to cause autoimmune-related side effects including endocrine dysfunctions. However, there are few reports on late-onset isolated adrenocorticotropic hormone (ACTH) deficiency caused by nivolumab. Read More

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http://dx.doi.org/10.1186/s12902-019-0335-xDOI Listing
February 2019

Growth characteristics of the novel goose parvovirus SD15 strain in vitro.

BMC Vet Res 2019 Feb 19;15(1):63. Epub 2019 Feb 19.

Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, No. 211 Huimin Road, Wenjiang District, Chengdu city, 611130, Sichuan province, China.

Background: Short beak and dwarfism syndrome (SBDS) was caused by novel goose parvovirus (NGPV)--a variant of goose parvovirus (GPV). Ducks infected with NGPV shows clinical signs including growth retardation and protrusion of the tongue from an atrophied beak. SBDS outbreak was first reported at the northern coastal provinces of China during 2015 and it was again reported in Sichuan, an inland province of China in 2016. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-019-1807-yDOI Listing
February 2019
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Evaluation of the impact of thyroiditis development in patients receiving immunotherapy with programmed cell death-1 inhibitors.

J Oncol Pharm Pract 2019 Feb 19:1078155219829813. Epub 2019 Feb 19.

2 Department of Medicine, Division of Hematology/Oncology, Henry Ford Hospital, Detroit, MI, USA.

Purpose: We evaluated if the development of thyroiditis in patients who received treatment with immune checkpoint inhibitors across various tumor types was associated with tumor response.

Methods: In this retrospective, single-center, cross-sectional study, patients with various tumor types who received treatment with nivolumab or pembrolizumab as standard of care were evaluated. The primary endpoint was to evaluate the objective response rate in patients who developed thyroiditis compared with patients who did not develop thyroiditis. Read More

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http://dx.doi.org/10.1177/1078155219829813DOI Listing
February 2019

First Report of Rhizoctonia solani AG 4 on Lamb's Lettuce in Italy.

Plant Dis 2006 Aug;90(8):1109

Center of Competence AGROINNOVA, University of Torino, Via Leonardo da Vinci, 44, 10095 Grugliasco, Italy.

Lamb's lettuce or corn salad (Valerianella olitoria) is increasingly grown in Italy and used primarily in the preparation of mixed processed salad. In the fall of 2005, plants of lamb's lettuce, cv Trophy, exhibiting a basal rot were observed in some commercial greenhouses near Bergamo in northern Italy. The crown of diseased plants showed extensive necrosis, progressing to the basal leaves, with plants eventually dying. Read More

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http://dx.doi.org/10.1094/PD-90-1109CDOI Listing

First Report of Leaf Blight Caused by Rhizoctonia solani AG 1B on Madagascar Periwinkle (Catharanthus roseus) in Italy.

Plant Dis 2006 Oct;90(10):1361

Center of Competence AGROINNOVA, University of Torino, Via Leonardo da Vinci, 44, 10095 Grugliasco, Italy.

Madagascar periwinkle (Catharanthus roseus), a plant belonging to the Apocynaceae family, is used for parks and gardens and sometimes grown in pots. At the end of the summer of 2005, a leaf blight was observed on plants in a public park of Torino. Semicircular, water-soaked lesions developed on leaves just above the soil line at the leaf-petiole junction and later along the leaf margins. Read More

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http://dx.doi.org/10.1094/PD-90-1361CDOI Listing
October 2006

A New Report of Cymbidium spp. Pseudobulb Rot Orchestrated by Erwinia carotovora, Fusarium oxysporum, and Mucor hiemalis f. sp. hiemalis.

Plant Dis 2006 Nov;90(11):1460

Molecular and Applied Mycology and Plant Pathology Lab. Department of Botany, University of Calcutta, India.

Cymbidium spp. is an orchid of great horticultural value cultivated extensively in Eastern Himalaya, India. Since 1995, growers have experienced huge crop losses in every monsoon month because of pseudobulb rot. Read More

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http://dx.doi.org/10.1094/PD-90-1460CDOI Listing
November 2006

Rose Dieback Caused by Trichothecium roseum in Argentina.

Plant Dis 2007 May;91(5):631

Laboratorio de Micología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires y PRHIDEBCONICET, Ciudad Universitaria. Pabellón 2, 4 Piso (1428) Buenos Aires, Argentina.

Rose (Rosa sp.) is one of the most important ornamentals in Argentina. Since 2002, a severe disease has been observed on crops cultivated for cut flowers and garden plants in Escobar, San Pedro, Río Negro, and the surrounding area of Buenos Aires and La Plata. Read More

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http://dx.doi.org/10.1094/PDIS-91-5-0631CDOI Listing

First Report of Leaf Blight on Coral Bells (Heuchera sanguinea) Caused by Rhizoctonia solani AG 1A in Italy.

Plant Dis 2007 Sep;91(9):1206

Centre of Competence for the Innovation in the Agro-Environmental Sector (AGROINNOVA), University of Torino, Via Leonardo da Vinci, 44, 10095 Grugliasco, Italy.

Heuchera sanguinea (Saxifragaceae), coral bells or alum root, is an herbaceous perennial used in parks and gardens and sometimes grown in pots for its heart-shaped leaves and upright panicles of bright red, tiny flowers produced in late spring. At the end of fall 2006, a leaf blight was observed on 50% of a crop of potted 45-day-old plants grown in a sphagnum peat/clay/perlite (70:20:10) substrate at temperatures ranging between 20 and 25°C in a nursery. Semicircular, water-soaked lesions developed on leaves just above the soil line at the leaf-petiole junction and later along the leaf margins. Read More

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http://dx.doi.org/10.1094/PDIS-91-9-1206BDOI Listing
September 2007