8,816 results match your criteria Cell Cycle[Journal]


Circular RNA circDLGAP4 is involved in lung cancer development through modulating microRNA-143/CDK1 axis.

Cell Cycle 2020 Jul 9:1-11. Epub 2020 Jul 9.

Department of Thoracic Surgery, The Second Hospital of Jilin University , Changchun, Jilin, China.

To investigate the role of circular RNA DLGAP4 (circDLGAP4) in lung cancer. circDLGAP4 expression was detected in lung cancer tissues and cell lines by PCR. The correlation between circDLGAP4 and clinicopathological characteristics of lung cancer patients was investigated. Read More

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http://dx.doi.org/10.1080/15384101.2020.1786649DOI Listing

Mesenchymal stem cells-derived exosomes ameliorate nucleus pulposus cells apoptosis via delivering miR-142-3p: therapeutic potential for intervertebral disc degenerative diseases.

Cell Cycle 2020 Jul 17;19(14):1727-1739. Epub 2020 Jun 17.

Department of Orthopedics, The First Affiliated Hospital of Soochow University , Suzhou, Jiangsu Province, China.

Intervertebral disc degeneration (IDD) is the main cause of lower back pain (LBP), and puzzles massive individuals worldwide. Mesenchymal stem cells (MSCs) transplantation has been demonstrated to potentially ameliorate IDD progression, while the underlying mechanism has not been fully explained. Interleukin-1β (IL-1β) was used to induce nucleus pulposus cells (NPCs) injury. Read More

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http://dx.doi.org/10.1080/15384101.2020.1769301DOI Listing

miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.

Cell Cycle 2020 Jul 17;19(14):1740-1753. Epub 2020 Jun 17.

Department of Obstetrics & Gynecology, Shengjing Hospital of China Medical University , Shenyang, China.

We previously performed high throughput RNA-seq in paired eutopic and ectopic endometrial specimen of endometriosis patients, and validated the results by qRT-PCR in endometriosis endometrial tissues. MiR-96-5p was significantly downregulated in ectopic endometrial tissues compared to eutopic tissues. In order to identify the role of miR-96-5p in endometriosis and endometrial cells, and investigate the underlying mechanisms, the Ishikawa and End1/E6E7 cell lines were transfected with miR-96-5p mimics, miR-96-5p inhibitors or TGFBR1 siRNA. Read More

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http://dx.doi.org/10.1080/15384101.2020.1777804DOI Listing

LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.

Cell Cycle 2020 Jul 5:1-10. Epub 2020 Jul 5.

Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, China.

LncRNAs play important roles in the regulation of podocyte apoptosis in diabetic nephropathy (DN). However, the role of lncRNA SNHG17 in controlling mitophagy-induced apoptosis of podocytes in DN is unknown. This study aims to elucidate the underlying mechanism of lncRNA SNHG17 in the regulation of mitophagy-induced apoptosis of podocytes in DN. Read More

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http://dx.doi.org/10.1080/15384101.2020.1783481DOI Listing

Purity estimation from differentially methylated sites using Illumina Infinium methylation microarray data.

Cell Cycle 2020 Jul 5:1-12. Epub 2020 Jul 5.

College of Information Science and Engineering, Hunan University , Changsha, Hunan, P.R. China.

Solid tissues collected from patient-driven clinical settings are composed of both normal and cancer cells, which often precede complications in data analysis and epigenetic findings. The Purity estimation of samples is crucial for reliable genomic aberration identification and uniform inter-sample and inter-patient comparisons as well. Here, an effective and flexible method has been developed and designed to estimate the level of methylation, which infers tumor purity without prior knowledge from the other datasets. Read More

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http://dx.doi.org/10.1080/15384101.2020.1789315DOI Listing

TRG-AS1 is a potent driver of oncogenicity of tongue squamous cell carcinoma through microRNA-543/Yes-associated protein 1 axis regulation.

Cell Cycle 2020 Jul 2:1-14. Epub 2020 Jul 2.

Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan, P.R. China.

The long noncoding RNA T cell receptor gamma locus antisense RNA 1 (TRG-AS1) plays an important role in glioblastoma progression. The objective of this study was to determine the expression status of TRG-AS1 in tongue squamous cell carcinoma (TSCC). The regulatory effects of TRG-AS1 depletion on the malignant processes of TSCC cells were illustrated both and . Read More

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http://dx.doi.org/10.1080/15384101.2020.1786622DOI Listing

Curcumin attenuates inflammation and cell apoptosis through regulating NF-κB and JAK2/STAT3 signaling pathway against acute kidney injury.

Cell Cycle 2020 Jul 2:1-11. Epub 2020 Jul 2.

Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University , Nanjing, China.

Curcumin alleviates septic acute kidney injury (SAKI); however, the underlying mechanism remained unclear. To explore this, SAKI cell model and mice model were conducted by using LPS and cecal ligation and puncture (CLP), respectively. Cell counting kit-8 (CCK-8) and enzyme-linked immunosorbent assay (ELISA) assays indicated that LPS reduced the viability, but upregulated the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6, whereas Curcumin pretreatment had no effect on viability, but reduced the levels of TNF-α and IL-6. Read More

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http://dx.doi.org/10.1080/15384101.2020.1784599DOI Listing

Correction.

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Cell Cycle 2020 Jul 2:1-2. Epub 2020 Jul 2.

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http://dx.doi.org/10.1080/15384101.2020.1787046DOI Listing

Human umbilical cord mesenchymal stem cell-derived exosome-mediated transfer of microRNA-133b boosts trophoblast cell proliferation, migration and invasion in preeclampsia by restricting SGK1.

Cell Cycle 2020 Jun 28:1-15. Epub 2020 Jun 28.

Department of Obstetric and Gynecology, Shengjing Hospital of China Medical University , Shengyang, Liaoning, China.

Objective: Exosomes have been documented to function in human diseases, yet their transfer of microRNA (miRNA) in preeclampsia (PE) has seldom been reported. This study intends to discuss the role of miR-133b derived from exosomes in human umbilical cord mesenchymal stem cells (hUC-MSCs) in trophoblast cell development in PE.

Methods: Placentas from PE patients and normal pregnant women were collected. Read More

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http://dx.doi.org/10.1080/15384101.2020.1769394DOI Listing

Proteomic analysis of meiosis and characterization of novel short open reading frames in the fission yeast .

Cell Cycle 2020 Jul 17;19(14):1777-1785. Epub 2020 Jun 17.

Department of Chromosome Biology, Max Perutz Labs, Vienna Biocenter, University of Vienna , Vienna, Austria.

Meiosis is the process by which haploid gametes are produced from diploid precursor cells. We used stable isotope labeling by amino acids in cell culture (SILAC) to characterize the meiotic proteome in the fission yeast . We compared relative levels of proteins extracted from cells harvested around meiosis I with those of meiosis II, and proteins from premeiotic S phase with the interval between meiotic divisions, when S phase is absent. Read More

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http://dx.doi.org/10.1080/15384101.2020.1779470DOI Listing

BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells.

Cell Cycle 2020 Jun 28:1-15. Epub 2020 Jun 28.

State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University , Nanjing, China.

In males, aging is accompanied by decline in serum testosterone levels due to impairment of testicular Leydig cells. The polycomb protein BMI1 has recently been identified as an anti-aging factor. In our previous study, BMI1 null mice showed decreased serum testosterone and Leydig cell population, excessive oxidative stress and p16/p19 signaling activation. Read More

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http://dx.doi.org/10.1080/15384101.2020.1779471DOI Listing

Low expression of miR-let-7a promotes cell growth and invasion through the regulation of c-Myc in oral squamous cell carcinoma.

Cell Cycle 2020 Jun 28:1-11. Epub 2020 Jun 28.

Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University , Nanjing, China.

In oral squamous cell carcinoma (OSCC), abnormal expression of microRNAs has been extensively reported. MiR-let-7a has been validated as a critical regulator of multiple cancers, but the biological process involved and its potential role in OSCC remain unknown.We first analyzed the differential expression of miR-let-7a in cancer tissues, adjacent noncancerous tissues and cell lines. Read More

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http://dx.doi.org/10.1080/15384101.2020.1786633DOI Listing

Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.

Cell Cycle 2020 Jun 28:1-11. Epub 2020 Jun 28.

Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang, People's Republic of China.

Colorectal cancer (CRC) is a common malignancy with high mortality. However, the roles of miR-425-5p and its underlying mechanism in CRC remain unknown. Here, RT-qPCR confirmed that miR-425-5p expression was increased by miR-425-5p mimic in SW480 cells and decreased by miR-425-5p inhibitor in LOVO cells. Read More

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http://dx.doi.org/10.1080/15384101.2020.1783058DOI Listing

RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.

Cell Cycle 2020 Jun 28:1-18. Epub 2020 Jun 28.

Division of Molecular and Cellular Biology, National Institute for Child Health and Human Development, National Institutes of Health , Bethesda, MD 20892, USA.

The Ran GTPase plays critical roles in multiple cellular processes including interphase nucleocytoplasmic transport and mitotic spindle assembly. During mitosis in mammalian cells, GTP-bound Ran (Ran-GTP) is concentrated near mitotic chromatin while GDP-bound Ran (Ran-GDP) is more abundant distal to chromosomes. This pattern spatially controls spindle formation because Ran-GTP locally releases spindle assembly factors (SAFs), such as Hepatoma Up-Regulated Protein (HURP), from inhibitory interactions near chromosomes. Read More

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http://dx.doi.org/10.1080/15384101.2020.1782036DOI Listing

miR-203 promotes HaCaT cell overproliferation through targeting LXR-α and PPAR-γ.

Cell Cycle 2020 Jun 28:1-13. Epub 2020 Jun 28.

Department of Dermatology, the Second Affiliated Hospital, The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine , Changsha, Hunan 410005, China.

Psoriasis is an immune-mediated chronic inflammatory skin disease. Keratinocyte hyperproliferation has been regarded as a significant event in psoriasis pathogenesis. Considering the vital role of miRNA-mediated mRNA repression in psoriasis pathogenesis, in the present study, we attempted to investigate the mechanism of keratinocyte overproliferation from the point of miRNA-mRNA regulation. Read More

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http://dx.doi.org/10.1080/15384101.2020.1783934DOI Listing

ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1.

Cell Cycle 2020 Jun 28:1-17. Epub 2020 Jun 28.

Center for Genomic Integrity, Institute for Basic Science , Ulsan, Korea.

Centrosomes are the primary microtubule-organizing centers that are important for mitotic spindle assembly. Centrosome amplification is commonly observed in human cancer cells and contributes to genomic instability. However, it is not clear how centrosome duplication is dysregulated in cancer cells. Read More

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http://dx.doi.org/10.1080/15384101.2020.1785724DOI Listing

Hsa_circ_0009910: oncogenic circular RNA targets microRNA-145 in ovarian cancer cells.

Cell Cycle 2020 Jun 26:1-12. Epub 2020 Jun 26.

Department of Gynecology, Shengli Oilfield Central Hospital , Dongying, China.

Circular RNAs (circRNAs) correlate with cancer cell phenotypes. Particularly, circRNAs mediate the cancer process as microRNAs (miRNAs) sponges. This study was to ascertain the roles of hsa_circ_0009910 in phenotypic aspects of ovarian cancer cells. Read More

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http://dx.doi.org/10.1080/15384101.2020.1731650DOI Listing

P73 C-terminus is dispensable for multiciliogenesis.

Cell Cycle 2020 Jul 25;19(14):1833-1845. Epub 2020 Jun 25.

Medical Research Council, Toxicology Unit, Department of Pathology, Cambridge University , Cambridge, UK.

The p53 family transcriptional factor p73 plays a pivotal role in development. Ablation of p73 results in severe neurodevelopmental defects, chronic infections, inflammation and infertility. In addition to this, Trp73 mice display severe alteration in the ciliated epithelial lining and the full-length -terminal isoform TAp73 has been implicated in the control of multiciliogenesis transcriptional program. Read More

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http://dx.doi.org/10.1080/15384101.2020.1783055DOI Listing

Five transcriptional factors reprogram fibroblast into myogenic lineage cells via paraxial mesoderm stage.

Cell Cycle 2020 Jul 17;19(14):1804-1816. Epub 2020 Jun 17.

Department of Pathology, College of Veterinary Medicine, Kyungpook National University , Daegu, Republic of Korea.

It is hard to supply satellite cells as a cell source for therapy of muscle degenerative disease since the sampling of muscle tissue is very invasive to a patient with muscular disease. Direct conversion allows us to get specific cell types by transduction of defined transcriptional factors. To induce myogenic direct conversion, we transduced five transcriptional factors including Pax3, Sox2, Klf4, c-Myc, and Esrrb into mouse embryonic fibroblasts. Read More

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http://dx.doi.org/10.1080/15384101.2020.1780384DOI Listing

inhibits hepatocellular carcinoma cell growth and metastasis.

Cell Cycle 2020 Jul 24;19(14):1846-1854. Epub 2020 Jun 24.

Shenzhen Laboratory of Tumor Cell Biology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen, P. R. China.

Hepatocellular carcinoma (HCC) has a poor prognosis, owing to its high potential for growth and metastasis. In this study, we aimed to investigate the roles of in human HCCcell growth and metastasis. We analyzed the expression level in human HCC tissues paired normal tissues in the Oncomine database, and assessed the relationship between the expression levels with HCC patient's overall survival and the prognostic value of in human HCC by Kaplan-Meier survival analysis. Read More

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http://dx.doi.org/10.1080/15384101.2020.1783472DOI Listing

Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in testis.

Cell Cycle 2020 Jul 23;19(14):1786-1803. Epub 2020 Jun 23.

Department of Biological Sciences, Tata Institute of Fundamental Research , Mumbai, India.

An extension of the G1 is correlated with stem cell differentiation. The role of cell cycle regulation during the subsequent transit amplification (TA) divisions is, however, unclear. Here, we report for the first time that in the male germline lineage, the transit amplification divisions accelerate after the second TA division. Read More

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http://dx.doi.org/10.1080/15384101.2020.1780381DOI Listing

Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the system.

Cell Cycle 2020 Jul 23;19(14):1817-1832. Epub 2020 Jun 23.

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC) , Gif-sur-Yvette, France.

Polo-like kinase 1 (Plk1) is a cell cycle kinase essential for mitosis progression, but also important for checkpoint recovery and adaptation in response to DNA damage and replication stress. However, although Plk1 is expressed in S phase, little is known about its function during unperturbed DNA replication. Using egg extracts, mimicking early embryonic replication, we demonstrate that Plk1 is simultaneously recruited to chromatin with pre-replication proteins where it accumulates throughout S phase. Read More

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http://dx.doi.org/10.1080/15384101.2020.1782589DOI Listing

Correction.

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Cell Cycle 2020 Jul 23;19(14):1855-1856. Epub 2020 Jun 23.

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http://dx.doi.org/10.1080/15384101.2020.1785749DOI Listing

The effect of alcoholic extract from leaves on HTLV-1 Tax activities.

Cell Cycle 2020 Jul 21;19(14):1768-1776. Epub 2020 Jun 21.

Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev , Beer-Sheva, Israel.

HTLV-1 is a human retrovirus responsible for adult T-cell leukemia (ATL) and certain other clinical disorders. The viral Tax oncoprotein plays a central role in HTLV-1 pathogenicity, mainly due to its capacity of inducing the transcriptional activity of various transcriptional factors like NFқB. () is considered as a traditional medicinal plant with valuable therapeutic effects. Read More

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http://dx.doi.org/10.1080/15384101.2020.1779455DOI Listing

Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast.

Cell Cycle 2020 Jul 18;19(14):1707-1715. Epub 2020 Jun 18.

ETH Zürich, Institute for Biochemistry , Zürich, Switzerland.

Budding yeast, , has been widely used as a model system to study cellular signaling in response to internal and external cues. Yeast was among the first organisms in which the architecture, feedback mechanisms and physiological responses of various MAP kinase signaling cascades were studied in detail. Although these MAP kinase pathways are activated by different signals and elicit diverse cellular responses, such as adaptation to stress and mating, they function as an interconnected signaling network, as they influence each other and, in some cases, even share components. Read More

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http://dx.doi.org/10.1080/15384101.2020.1779469DOI Listing

RZZ-SPINDLY-DYNEIN: you got to keep 'em separated.

Cell Cycle 2020 Jul 16;19(14):1716-1726. Epub 2020 Jun 16.

IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto, Portugal.

To maintain genome stability, chromosomes must be equally distributed among daughter cells at the end of mitosis. The accuracy of chromosome segregation requires sister-kinetochores to stably attach to microtubules emanating from opposite spindle poles. However, initial kinetochore-microtubule interactions are able to turnover so that defective attachment configurations that typically arise during early mitosis may be corrected. Read More

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http://dx.doi.org/10.1080/15384101.2020.1780382DOI Listing

miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1.

Cell Cycle 2020 Jul 16;19(14):1754-1767. Epub 2020 Jun 16.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine , Shanghai, P.R. China.

Retinal degenerations, which lead to irreversible decline in visual function, are still no effective recovery treatments. Currently, retinal progenitor cell (RPC) transplantation therapy is expected to provide a new approach to treat these diseases; however, the limited proliferation capacity and differentiation potential toward specific retinal neurons of RPCs hinder their potential clinical applications. microRNAs have been reported to serve as important regulators in the cell fate determination of stem/progenitor cells. Read More

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http://dx.doi.org/10.1080/15384101.2020.1777805DOI Listing

CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373/HIF-1a axis.

Cell Cycle 2020 Jul 31;19(13):1696-1705. Epub 2020 May 31.

Department of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University , Zhengzhou, China.

Osteoarthritis (OA) is a very common chronic and degenerative joint disease characterized by persistent destruction of articular cartilage. Recently, increasing evidence showed that circular RNAs (circRNAs) play critical roles in OA progression. However, the functions of circRNAs in OA and their underlying mechanisms of action remain unclear. Read More

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http://dx.doi.org/10.1080/15384101.2020.1772545DOI Listing

Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1.

Cell Cycle 2020 Jul 26;19(13):1677-1695. Epub 2020 May 26.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, China.

Chronic stress which is common in the current society can be harmful to female reproduction and is associated with oocyte defects. However, the underlying mechanisms remain largely unknown. Herein, by using a mouse model of chronic restraint stress, we demonstrated that chronic stress could induce meiotic spindle abnormalities, chromatin misalignment, mitochondrial dysfunction and elevated ROS levels in oocytes in vivo, all of which were normalized by the administration of melatonin. Read More

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http://dx.doi.org/10.1080/15384101.2020.1767403DOI Listing

Long non-coding RNA SLC16A1-AS1: its multiple tumorigenesis features and regulatory role in cell cycle in oral squamous cell carcinoma.

Cell Cycle 2020 Jul 25;19(13):1641-1653. Epub 2020 May 25.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases , Chengdu, China.

Altered expressions of long non-coding RNAs (lncRNAs) are potential cancer prognostic biomarkers that play a critical role in the development of tumorigenesis and metastasis of cancer. However, the relationship between the expression of lncRNAs in oral squamous cell carcinoma (OSCC) and the diagnosis, progression, and prognosis of OSCC has not been thoroughly elucidated. To identify the differentially expressed lncRNAs between OSCC tissue and normal tissue, RNA-Seq data were used. Read More

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http://dx.doi.org/10.1080/15384101.2020.1762048DOI Listing

Sevoflurane attenuates cardiomyocyte apoptosis by mediating the miR-219a/AIM2/TLR4/MyD88 axis in myocardial ischemia/reperfusion injury in mice.

Cell Cycle 2020 Jul 23;19(13):1665-1676. Epub 2020 May 23.

Department of Anesthesiology Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University , ZhengZhou, Henan, P.R. China.

Myocardial infarction (MI) is a vital cause of death and disability globally. The primary treatment for diminishing acute myocardial ischemic injury is myocardial reperfusion, which may induce cardiomyocyte death. Our aim is to unravel the mechanism of sevoflurane (Sev) in microRNA-219a (miR-219a)-mediated regulation of absent in melanoma 2 (AIM2) and TLR4/MyD88 pathway during myocardial ischemia/reperfusion (I/R). Read More

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http://dx.doi.org/10.1080/15384101.2020.1765512DOI Listing

Abnormally high expression of HOXA2 as an independent factor for poor prognosis in glioma patients.

Cell Cycle 2020 Jul 21;19(13):1632-1640. Epub 2020 May 21.

Department of Orthopaedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University , Zhengzhou, Henan, China.

In recent years, studies have revealed HOXA2 as a new oncogene, but its function is unknown in gliomas. We aimed to reveal the relationship between HOXA2 and glioma based on the Chinese Glioma Genome Atlas(CGGA) and the cancer genome atlas (TCGA). HOXA2 expression data and clinically relevant information of glioma patients were obtained from the CGGA and TCGA containing 1447 glioma tissues and five non-tumor brain tissues. Read More

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http://dx.doi.org/10.1080/15384101.2020.1762038DOI Listing

Reticulocalbin-1 knockdown increases the sensitivity of cells to Adriamycin in nasopharyngeal carcinoma and promotes endoplasmic reticulum stress-induced cell apoptosis.

Cell Cycle 2020 Jul 21;19(13):1576-1589. Epub 2020 May 21.

Department of Rheumatology, The Second Hospital of Shanxi Medical University , Taiyuan, P.R. China.

Nasopharyngeal carcinoma (NPC) mainly appears in southeastern Asian countries, including China. Adriamycin (ADM), a type of antitumor drug, is widely applied in treatments against various cancers. Nevertheless, cancer cells will eventually develop drug resistance to ADM. Read More

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http://dx.doi.org/10.1080/15384101.2020.1733750DOI Listing

Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells.

Cell Cycle 2020 Jul 19;19(13):1590-1601. Epub 2020 May 19.

Institute for Refractory Cancer Research, Current Address: Samsung Medical Center , Seoul, Republic of Korea.

p97 has recently emerged as a therapeutic target for cancer due to its essential functions in protein homeostasis. CB-5083 is a first-in-class, potent and selective ATP-competitive p97 inhibitor that induces proteotoxic stress in cancer cells. Potential mechanisms regulating the sensitivity of cells to p97 inhibition remain poorly studied. Read More

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http://dx.doi.org/10.1080/15384101.2020.1754584DOI Listing

Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma.

Cell Cycle 2020 Jul 18;19(13):1602-1610. Epub 2020 May 18.

Shuguang Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai, P.R. China.

Myeloma Overexpressed (MYEOV) is closely related to cell growth and differentiation in many cancer types. However, the role of this protein-coding gene in pancreatic ductal adenocarcinoma (PDAC) has rarely been investigated. In this study, we demonstrated that MYEOV was higher expressed in tumor tissues compared with adjacent normal pancreas tissues (ANPTs) both in mRNA and protein levels. Read More

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http://dx.doi.org/10.1080/15384101.2020.1757243DOI Listing

Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.

Cell Cycle 2020 Jul 18;19(13):1611-1620. Epub 2020 May 18.

Department of Thoracic Surgery, Peking Union Medical College Hospital , Beijing City, PR. China.

Background/aims: CircABCB10 function as an endogenous miRNA sponge plays an important role in various tumors. This experimental design was based on circABCB10 to explore the pathogenesis of non-small cell lung cancer (NSCLC). : CircRNA microarray was used to examine circRNA expression profiles in lung cancer from 3 NSCLC patients and paired healthy lung tissues. Read More

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http://dx.doi.org/10.1080/15384101.2020.1761617DOI Listing

LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.

Cell Cycle 2020 Jul 18;19(13):1621-1631. Epub 2020 May 18.

Department of Neurosurgery, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde Foshan) , Foshan, Guangdong, China.

Long noncoding RNAs (lncRNAs) are key players in cancer progression. However, the function of lncRNA NNT-AS1 on glioma is unclear. In the present study, a total of 73 tumor tissues and matched adjacent non-tumor tissues were collected, and glioma cell lines were cultured . Read More

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http://dx.doi.org/10.1080/15384101.2020.1762037DOI Listing

Cyclin A2 is essential for mouse gonocyte maturation.

Cell Cycle 2020 Jul 18;19(13):1654-1664. Epub 2020 May 18.

Department of Genetics & Development, Columbia University Medical Center , New York, NY, USA.

In mammals, male gonocytes are derived from primordial germ cells during embryogenesis, enter a period of mitotic proliferation, and then become quiescent until birth. After birth, the gonocytes proliferate and migrate from the center of testicular cord toward the basement membrane to form the pool of spermatogonial stem cells (SSCs) and establish the SSC niche architecture. However, the molecular mechanisms underlying gonocyte proliferation, migration and differentiation are largely unknown. Read More

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http://dx.doi.org/10.1080/15384101.2020.1762314DOI Listing

Disassembly of the Shieldin Complex by TRIP13.

Cell Cycle 2020 Jul 18;19(13):1565-1575. Epub 2020 May 18.

Department of Radiation Oncology, Dana-Farber Cancer Institute , Boston, MA, USA.

In the past decade, the study of the major DNA double strand break (DSB) repair pathways, homologous recombination (HR) and classical non-homologous end joining (C-NHEJ), has revealed a vast and intricate network of regulation.  The choice between HR and C-NHEJ is largely controlled at the step of DNA end-resection. A pro-C-NHEJ cascade commencing with 53BP1 and culminating in the newly discovered REV7-Shieldin complex impedes end resection and therefore HR. Read More

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http://dx.doi.org/10.1080/15384101.2020.1758435DOI Listing

STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A.

Cell Cycle 2020 Jun 13;19(12):1502-1516. Epub 2020 May 13.

Department of Medical Oncology, Harbin Medical University Cancer Hospital , Harbin, Heilongjiang, China.

Long non-coding RNAs (lncRNAs) have been proposed as suppressors or promoters in many tumor processes. LncRNA LINC01123 (LINC01123) was a newly identified lncRNA which was firstly functionally analyzed in lung cancer. However, its expression and function in other tumor types were rarely reported. Read More

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http://dx.doi.org/10.1080/15384101.2020.1757936DOI Listing

A guiding torch at the poles: the multiple roles of spindle microtubule-organizing centers during cell division.

Cell Cycle 2020 Jun 13;19(12):1405-1421. Epub 2020 May 13.

Centro Andaluz de Biología Molecular Y Medicina Regenerativa (CABIMER) / CSIC - Universidad de Sevilla - Universidad Pablo de Olavide , Sevilla, Spain.

The spindle constitutes the cellular machinery that enables the segregation of the chromosomes during eukaryotic cell division. The microtubules that form this fascinating and complex genome distribution system emanate from specialized structures located at both its poles and known as microtubule-organizing centers (MTOCs). Beyond their structural function, the spindle MTOCs play fundamental roles in cell cycle control, the activation and functionality of the mitotic checkpoints and during cellular aging. Read More

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http://dx.doi.org/10.1080/15384101.2020.1754586DOI Listing

Zooming in on chromosome dynamics.

Cell Cycle 2020 Jun 13;19(12):1422-1432. Epub 2020 May 13.

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee , Dundee, UK.

Until recently, our understanding of chromosome organization in higher eukaryotic cells has been based on analyses of large-scale, low-resolution changes in chromosomes structure. More recently, CRISPR-Cas9 technologies have allowed us to "zoom in" and visualize specific chromosome regions in live cells so that we can begin to examine in detail the dynamics of chromosome organization in individual cells. In this review, we discuss traditional methods of chromosome locus visualization and look at how CRISPR-Cas9 gene-targeting methodologies have helped improve their application. Read More

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http://dx.doi.org/10.1080/15384101.2020.1757242DOI Listing

Chrysophanol protects PC12 cells against oxygen glucose deprivation-evoked injury by up-regulating miR-216a.

Cell Cycle 2020 Jun 13;19(12):1433-1442. Epub 2020 May 13.

Department of Traditional Chinese Medicine, Jining No.1 People's Hospital , Jining, China.

Background: Cerebral stroke refers to an acute onset of neurological deficit syndrome. In this research, we attempted to probe into the underlying mechanisms by which chrysophanol (CP) performed its regulatory roles in cerebral stroke. OGD inducement was conducted in PC12 cells to construct a cerebral stroke model. Read More

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http://dx.doi.org/10.1080/15384101.2020.1731655DOI Listing

Long noncoding RNA RHPN1-AS1 exerts pro-oncogenic actions in osteosarcoma by functioning as a molecular sponge of miR-506 to positively regulate SNAI2 expression.

Cell Cycle 2020 Jun 13;19(12):1517-1529. Epub 2020 May 13.

Department of Spinal Surgery, Shijiazhuang Third Hospital , Shijiazhuang, Hebei, P.R. China.

The long noncoding RNA, RHPN1 antisense RNA 1 (), performs important regulatory actions in the progression of many human cancers. In this study, we aimed to analyze expression in osteosarcoma (OS) and to assess the influence of knockdown on the malignant behavior of OS cells. The molecular mechanisms by which affects the oncogenicity of OS were explored too. Read More

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http://dx.doi.org/10.1080/15384101.2020.1762039DOI Listing

Novel agent DMAMCL suppresses osteosarcoma growth and decreases the stemness of osteosarcoma stem cell.

Cell Cycle 2020 Jun 13;19(12):1530-1544. Epub 2020 May 13.

Department of Pediatrics, Shengjing Hospital of China Medical University , Shenyang, China.

Osteosarcoma (OS) is the most common primary malignancy of bone that mostly affects children, adolescents, and young people. Despite advances have been made in multimodal therapy of OS, the long-term survival rate has reached a plateau, and the main obstacles are bad response to chemotherapy and gained chemoresistance. In this study, we tested the therapeutic effect of a newly reported drug, DMAMCL, on OS. Read More

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http://dx.doi.org/10.1080/15384101.2020.1762041DOI Listing

DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins.

Cell Cycle 2020 Jun 7;19(12):1545-1561. Epub 2020 May 7.

Laboratory of Signaling in Biomolecular Systems, Department of Biochemistry, Institute of Chemistry, University of Sao Paulo , São Paulo-SP, Brazil.

The DUSP3 phosphatase regulates cell cycle, proliferation, apoptosis and senescence of different cell types, lately shown as a mediator of DNA repair processes. This work evaluated the impact of DUSP3 loss of function () on DNA repair-proficient fibroblasts (MRC-5), NER-deficient cell lines (XPA and XPC) and translesion DNA synthesis (TLS)-deficient cells (XPV), after UV-radiation stress. The levels of DNA strand breaks, CPDs and 6-4-PPs have accumulated over time in all cells under DUSP3 , with a significant increase in NER-deficient lines. Read More

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http://dx.doi.org/10.1080/15384101.2020.1762043DOI Listing

miR-296-5p inhibits IL-1β-induced apoptosis and cartilage degradation in human chondrocytes by directly targeting TGF-β1/CTGF/p38MAPK pathway.

Cell Cycle 2020 Jun 7;19(12):1443-1453. Epub 2020 May 7.

Department of Orthopedics, Yantaishan Hospital , Yantai, Shandong Province, China.

Osteoarthritis (OA) is characterized by apoptosis of chondrocytes and an imbalance of extracellular matrix (ECM) synthesis and catabolism. Emerging evidence has demonstrated that miRNAs are involved in OA pathologies, but the role of miR-296-5p in OA remains unclear. The present study proposes to reveal the functions and mechanisms of miR-296-5p in a cell model of OA. Read More

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http://dx.doi.org/10.1080/15384101.2020.1750813DOI Listing

Anti-inflammatory effect of up-regulated microRNA-221-3p on coronary heart disease via suppressing NLRP3/ASC/pro-caspase-1 inflammasome pathway activation.

Cell Cycle 2020 Jun 6;19(12):1478-1491. Epub 2020 May 6.

Department of Cardiovascular, Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine , Shanghai, China.

Objective: As some evidence has demonstrated the role of microRNA-221 (miR-221) on coronary heart disease (CHD), the aim of the present study was to investigate the effect of miR-221-3p on CHD via regulating NLRP3/ASC/pro-caspase-1 inflammasome pathway.

Methods: Sixty CHD patients and 60 healthy controls were collected to detect the expression of miR-221-3p, NLRP3, ASC, pro-caspase-1 in peripheral blood and the contents of related factors in serum. The rats model of CHD was injected with miR-221-3p agomir or miR-221-3p antagomir to explore its functions in miR-221-3p, NLRP3, ASC and pro-caspase-1 expression, electrocardiogram data, cardiomyocytes apoptosis, myocardial injury, inflammatory reaction and oxidative stress of CHD rats. Read More

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http://dx.doi.org/10.1080/15384101.2020.1754562DOI Listing

Overexpression of circARF3 mitigates TNF-α-induced inflammatory damage by up-regulating miR-125b.

Cell Cycle 2020 Jun 24;19(11):1253-1264. Epub 2020 Apr 24.

Department of Neurology, The Affiliated Hospital of Qingdao University , Qingdao, 266000, Shandong, China.

Encephalitis is the highest disability illness. We studied the function and mechanisms of circular RNA circARF3 (circARF3) in neurocyte cell inflammatory damage. CCK-8 assay and flow cytometry were, respectively, employed for examining the influences of tumor necrosis factor α (TNF-α), circARF3 and microRNA (miR)-125b on cell viability and apoptosis. Read More

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http://dx.doi.org/10.1080/15384101.2020.1731652DOI Listing

Microvesicles derived from human umbilical cord mesenchymal stem cells ameliorate renal ischemia-reperfusion injury via delivery of miR-21.

Cell Cycle 2020 Jun 24;19(11):1285-1297. Epub 2020 Apr 24.

Department of Urology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital , Zhengzhou, Henan, China.

Microvesicles (MVs) derived from human umbilical cord mesenchymal stem cells (hUC-MSCs-MVs) and miR-21 were demonstrated to ameliorate renal ischemia-reperfusion injury (IRI). Since hUC-MSC-MVs contained a substantial quantity of miR-21, we speculated that miR-21 might account for a part of the therapeutic effects of hUC-MSCs-MVs. The human tubule epithelial (HK-2) cells were cultured under low oxygen (LO) condition to mimic a cellular IRI model. Read More

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http://dx.doi.org/10.1080/15384101.2020.1748940DOI Listing