610 results match your criteria Cell Communication and Signaling [Journal]


The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles.

Cell Commun Signal 2019 Feb 21;17(1):16. Epub 2019 Feb 21.

Department of Cell Biology, Army Medical University, Gaotanyan street No. 30, Shapingba, Chongqing, 400038, China.

Background: The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein that controls this process has not been revealed.

Methods: The expression of BMP6 was determined via in situ hybridization and immunofluorescence. Read More

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http://dx.doi.org/10.1186/s12964-019-0330-xDOI Listing
February 2019

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells.

Cell Commun Signal 2019 Feb 20;17(1):14. Epub 2019 Feb 20.

Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park Bâtiment G, 1015, Lausanne, Switzerland.

Background: Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is associated with a pronounced increase in mitochondrial respiration. Read More

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http://dx.doi.org/10.1186/s12964-019-0326-6DOI Listing
February 2019

Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer.

Cell Commun Signal 2019 Feb 20;17(1):15. Epub 2019 Feb 20.

Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.

Background: ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by membrane physical properties. The present study aims to investigate the influence of membrane cholesterol contents on ErbB2 status and cellular responses to its tyrosine kinase inhibitors. Read More

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http://dx.doi.org/10.1186/s12964-019-0328-4DOI Listing
February 2019

Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells.

Cell Commun Signal 2019 Feb 19;17(1):13. Epub 2019 Feb 19.

Department of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 411A, Oklahoma City, OK, 73104, USA.

Background: Exosomes are small membrane-bound vesicles that contribute to tumor progression and metastasis by mediating cell-to-cell communication and modifying the tumor microenvironment at both local and distant sites. However, little is known about the predominant factors in exosomes that contribute to breast cancer (BC) progression. MTA1 is a transcriptional co-regulator that can act as both a co-activator and co-repressor to regulate pathways that contribute to cancer development. Read More

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http://dx.doi.org/10.1186/s12964-019-0325-7DOI Listing
February 2019

Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation.

Cell Commun Signal 2019 Feb 13;17(1):12. Epub 2019 Feb 13.

Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.

Background: The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroid disease. While high-dose therapy has been beneficial to several cancer patients, many studies have indicated this clinical benefit was limited to patients having BRAF mutation. BRAF-targeted paired box gene-8 (PAX8), a thyroid-specific transcription factor, generally dysregulated in BRAF-mutated thyroid cancer. Read More

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http://dx.doi.org/10.1186/s12964-019-0322-xDOI Listing
February 2019
1 Read

Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.

Cell Commun Signal 2019 Feb 11;17(1):11. Epub 2019 Feb 11.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Background: Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC contraction was affected by the natural compound oroxylin A, and elucidated the underlying mechanism.

Methods: Cell contraction and glycolysis were examined in cultured human HSCs and mouse liver fibrosis model upon oroxylin A intervention using diversified cellular and molecular assays, as well as genetic approaches. Read More

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http://dx.doi.org/10.1186/s12964-019-0324-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371416PMC
February 2019
3.378 Impact Factor

Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis.

Cell Commun Signal 2019 Jan 31;17(1):10. Epub 2019 Jan 31.

Department of Biosciences, Division of Microbiology, University of Salzburg, Paris-Lodron University of Salzburg, Billroth Str. 11, A-5020, Salzburg, Austria.

Background: Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate the oncoprotein cytotoxin-associated gene A (CagA). The role of c-Abl in CagA-dependent pathways is well established; however, the knowledge of CagA-independent c-Abl processes is scarce. Read More

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http://dx.doi.org/10.1186/s12964-019-0323-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357398PMC
January 2019
5 Reads

Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway.

Cell Commun Signal 2019 Jan 25;17(1). Epub 2019 Jan 25.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.

Background: Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghrelin on glucose homeostasis and insulin signaling in the liver. Read More

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http://dx.doi.org/10.1186/s12964-019-0321-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347823PMC
January 2019
4 Reads

Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway.

Cell Commun Signal 2019 Jan 25;17(1). Epub 2019 Jan 25.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 West Yanjiang Road, Guangzhou, 510120, Guangdong, China.

Background: To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.

Methods: Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeline (ChAMP) analysis was employed for differential methylated points (DMPs) and the differential methylation regions (DMRs) screening. Read More

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http://dx.doi.org/10.1186/s12964-018-0316-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347846PMC
January 2019
6 Reads

The protein kinase Cmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in budding yeast.

Cell Commun Signal 2019 Jan 21;17(1). Epub 2019 Jan 21.

Laboratory for Yeast Molecular and Cell Biology, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, Shandong, China.

Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the calcium signalling pathway, the protein kinase gene CMK2, the sphingolipid homeostasis-related gene ORM2 and the gene SIF2 encoding the WD40 repeat-containing subunit of Set3C histone deacetylase complex are involved in the calcium sensitivity of yeast cells to extracellular calcium. Cmk2 and the transcription factor Crz1 have opposite functions in the response of yeast cells to calcium stress. Read More

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http://dx.doi.org/10.1186/s12964-019-0320-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341702PMC
January 2019

Extracellular vesicles in bone: "dogrobbers" in the "eternal battle field".

Cell Commun Signal 2019 Jan 18;17(1). Epub 2019 Jan 18.

Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Throughout human life, bone is constantly in a delicate dynamic equilibrium of synthesis and resorption, hosting finely-tuned bone mineral metabolic processes for bone homeostasis by collaboration or symphony among several cell types including osteoclasts (OCs), osteoblasts (OBs), osteocytes (OYs), vascular endothelial cells (ECs) and their precursors. Beyond these connections, a substantial level of communication seems to occur between bone and other tissues, and together, they form an organic unit linked to human health and disease. However, the current hypothesis, which includes growth factors, hormones and specific protein secretion, incompletely explains the close connections among bone cells or between bone and other tissues. Read More

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http://dx.doi.org/10.1186/s12964-019-0319-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339294PMC
January 2019
5 Reads
3.378 Impact Factor

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.

Cell Commun Signal 2019 Jan 16;17(1). Epub 2019 Jan 16.

Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

Background: Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated K1. Read More

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http://dx.doi.org/10.1186/s12964-018-0317-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335768PMC
January 2019
3 Reads
3.378 Impact Factor

Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.

Cell Commun Signal 2019 Jan 14;17(1). Epub 2019 Jan 14.

Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Collaborative Innovation Center of Cancer Medicine, Shanghai Medical College, Fudan University, 270 Dong'an Road, Shanghai, 200032, China.

Background: As the first member of the metastasis-associated protein (MTA) family, MTA1 and another MTA family member, MTA2, have both been reported to promote breast cancer progression and metastasis. However, the difference and relationship between MTA1 and MTA2 have not been fully elucidated.

Methods: Transwell assays were used to assess the roles of MTA1 and MTA2 in the metastasis of ZR-75-30 luminal B breast cancer cells in vitro. Read More

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http://dx.doi.org/10.1186/s12964-019-0318-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332694PMC
January 2019
2 Reads

Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma.

Cell Commun Signal 2019 Jan 11;17(1). Epub 2019 Jan 11.

The Base of "111 Project" for Biomechanics and Tissue Repair Engineering, Bioengineering college and Life Science College, Chongqing University, Chongqing, 400044, China.

Background: Despite therapeutic advancements (e.g. B-RAF inhibitors) targeting cutaneous melanoma, many cellular processes, including inducible heme oxygenase 1 (HO-1), counteract treatments for malignancies. Read More

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http://dx.doi.org/10.1186/s12964-018-0313-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329143PMC
January 2019
3 Reads

Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway.

Cell Commun Signal 2019 Jan 10;17(1). Epub 2019 Jan 10.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Xi'an Road 5333#, Changchun, Jilin, 130062, People's Republic of China.

Background: Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, is essential for alleviating APAP-induced hepatotoxicity. Corilagin (Cori) is a natural polyphenol compound that possesses effective antioxidant activity; however, the protective effect of Cori on APAP-induced hepatotoxicity is still unknown. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0314-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327405PMC
January 2019
4 Reads

Exosomes in hepatocellular carcinoma: a new horizon.

Cell Commun Signal 2019 Jan 7;17(1). Epub 2019 Jan 7.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.

Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance. Read More

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http://dx.doi.org/10.1186/s12964-018-0315-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323788PMC
January 2019
4 Reads

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation.

Cell Commun Signal 2018 12 19;16(1):101. Epub 2018 Dec 19.

Instituto de Biología Molecular y Celular del Cáncer (IMBCC), Universidad de Salamanca-CSIC, Salamanca, Spain.

Background: Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in platelet activation and regulates several differentiation processes. Read More

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http://dx.doi.org/10.1186/s12964-018-0311-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299959PMC
December 2018
1 Read

Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression.

Cell Commun Signal 2018 12 18;16(1):100. Epub 2018 Dec 18.

Jiangsu Key laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.

Background: Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adipocyte-breast cancer interactions have been considered important for the promotion of breast cancer metastasis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0309-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299564PMC
December 2018
4 Reads

Blockade of ARHGAP11A reverses malignant progress via inactivating Rac1B in hepatocellular carcinoma.

Cell Commun Signal 2018 12 13;16(1):99. Epub 2018 Dec 13.

Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background: The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of currently known targets has not yet led to successful clinical outcome. More understanding about the regulatory mechanisms in HCC is necessary for developing new effective therapeutic strategies for HCC patients. Read More

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http://dx.doi.org/10.1186/s12964-018-0312-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293628PMC
December 2018
9 Reads

Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.

Cell Commun Signal 2018 12 12;16(1):98. Epub 2018 Dec 12.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.

Background: Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.

Methods: Using single receptor-deficient platelets from TAM knockout mice in the C57BL/6 J strain, we performed a knockout study using single TAM-deficient mice. Read More

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http://dx.doi.org/10.1186/s12964-018-0308-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291976PMC
December 2018
3 Reads

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle.

Cell Commun Signal 2018 12 7;16(1):97. Epub 2018 Dec 7.

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by the loss of muscle strength and mass, is one of the pathological conditions regulated by TGF-β1, but the underlying mechanism involved in the atrophic effects of TGF-β1 is not fully understood.

Methods: Mice sciatic nerve transection model was created and gastrocnemius were analysed by western blot, immunofluorescence staining and fibre diameter quantification after 2 weeks. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0310-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286536PMC
December 2018
8 Reads

bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling.

Cell Commun Signal 2018 12 5;16(1):96. Epub 2018 Dec 5.

Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich Heine University, Düsseldorf, Germany.

Background: Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. Read More

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http://dx.doi.org/10.1186/s12964-018-0307-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282345PMC
December 2018
3 Reads

Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.

Cell Commun Signal 2018 12 5;16(1):95. Epub 2018 Dec 5.

Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, 150040, People's Republic of China.

Background: The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. Jumeau (Jumu) is a member of the winged-helix/forkhead (FKH) transcription factor family and is required for Drosophila development. Adult jumu mutant flies show defective hemocyte phagocytosis and a weaker defense capability against pathogen infection. Read More

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http://dx.doi.org/10.1186/s12964-018-0305-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280549PMC
December 2018
2 Reads

Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice.

Cell Commun Signal 2018 12 3;16(1):93. Epub 2018 Dec 3.

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFRα in non-cancerous hepatocytes and liver fibrosis is unclear. Read More

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http://dx.doi.org/10.1186/s12964-018-0306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276164PMC
December 2018
2 Reads

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.

Cell Commun Signal 2018 12 4;16(1):94. Epub 2018 Dec 4.

Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-driven cell-invasive phenotype. We found that AMAP1 levels are under the control of p53 (TP53 gene product) in epithelial cells but not in fibroblasts, and here addressed that molecular basis of the epithelial-specific function of p53 in suppressing invasiveness via targeting AMAP1. Read More

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http://dx.doi.org/10.1186/s12964-018-0302-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278066PMC
December 2018
9 Reads

Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes.

Cell Commun Signal 2018 11 29;16(1):91. Epub 2018 Nov 29.

Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, Heilongjiang Province, China.

Background: The link between cardiac diseases and cognitive deterioration has been accepted from the concept of "cardiogenic dementia", which was proposed in the late 1970s. However, the molecular mechanism is unclarified.

Methods: The two animal models used in this study were cardiac-specific overexpression of microRNA-1-2 transgenic (Tg) mice and a myocardial infarction mouse model generated by left coronary artery ligation (LCA). Read More

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http://dx.doi.org/10.1186/s12964-018-0303-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267908PMC
November 2018
3 Reads

Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.

Cell Commun Signal 2018 11 29;16(1):92. Epub 2018 Nov 29.

Department of General Surgery, the Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, China.

Background: Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (TNBC) to chemotherapy remains a major clinical problem. Our previous study demonstrated that the expression levels of PTN and its receptor PTPRZ1 were upregulated in recurrent TNBC tissue after chemotherapy, and this increase was closely related to poor prognosis in those patients. Read More

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http://dx.doi.org/10.1186/s12964-018-0304-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267809PMC
November 2018
1 Read

Correction to: Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

Cell Commun Signal 2018 11 26;16(1):90. Epub 2018 Nov 26.

Department of Biotechnology and Health Science, Molecular Biotechnology Center, Università di Torino, Via Nizza, 52, Torino, Italy.

Following publication of the original article [1], the authors reported an error in the name of the 11th author. The author's name was incorrectly published as "Vincenzo Calautti", instead of "Enzo Calautti". Read More

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http://dx.doi.org/10.1186/s12964-018-0296-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258440PMC
November 2018
3 Reads

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis.

Cell Commun Signal 2018 11 23;16(1):89. Epub 2018 Nov 23.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Hankou Road 22, Nanjing, 210093, China.

Background: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident mesenchymal stem cells (LR-MSCs) have been identified as an important contributor to myofibroblast activation in pulmonary fibrosis. Macrophages are also believed to play a critical role in pulmonary fibrosis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0300-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260991PMC
November 2018
10 Reads
3.380 Impact Factor

SOX2 as a novel contributor of oxidative metabolism in melanoma cells.

Cell Commun Signal 2018 11 22;16(1):87. Epub 2018 Nov 22.

Department of Clinical and Experimental Biomedical Sciences "Mario Serio", Section of Experimental Pathology and Oncology, University of Florence, Viale G.B. Morgagni, 50, 50134, Florence, Italy.

Background: Deregulated metabolism is a hallmark of cancer and recent evidence underlines that targeting tumor energetics may improve therapy response and patient outcome. Despite the general attitude of cancer cells to exploit the glycolytic pathway even in the presence of oxygen (aerobic glycolysis or "Warburg effect"), tumor metabolism is extremely plastic, and such ability to switch from glycolysis to oxidative phosphorylation (OxPhos) allows cancer cells to survive under hostile microenvironments. Recently, OxPhos has been related with malignant progression, chemo-resistance and metastasis. Read More

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http://dx.doi.org/10.1186/s12964-018-0297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249961PMC
November 2018
10 Reads

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

Cell Commun Signal 2018 11 22;16(1):88. Epub 2018 Nov 22.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Background: Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer cells in the same microenvironment appear not to be affected. Mechanisms whereby cancer cells resist accelerated tryptophan degradation are not completely understood. Read More

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http://dx.doi.org/10.1186/s12964-018-0301-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251197PMC
November 2018
1 Read

Regulation of MRTF-A by JMY via a nucleation-independent mechanism.

Cell Commun Signal 2018 11 21;16(1):86. Epub 2018 Nov 21.

Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg, 06114, Halle (Saale), Germany.

Background: MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression. The activity of MRTF-A is critically dependent on the dissociation of G-actin from N-terminal RPEL motifs. MRTF-SRF induction often correlates with enhanced polymerization of F-actin. Read More

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http://dx.doi.org/10.1186/s12964-018-0299-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249979PMC
November 2018
14 Reads

Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism.

Cell Commun Signal 2018 11 20;16(1):85. Epub 2018 Nov 20.

Department of Chemical Engineering, Bogazici University, Istanbul, Turkey.

Background: Rapamycin is a potent inhibitor of the highly conserved TOR kinase, the nutrient-sensitive controller of growth and aging. It has been utilised as a chemotherapeutic agent due to its anti-proliferative properties and as an immunosuppressive drug, and is also known to extend lifespan in a range of eukaryotes from yeast to mammals. However, the mechanisms through which eukaryotic cells adapt to sustained exposure to rapamycin have not yet been thoroughly investigated. Read More

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http://dx.doi.org/10.1186/s12964-018-0298-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245637PMC
November 2018
12 Reads

Autologous blood transfusion augments impaired wound healing in diabetic mice by enhancing lncRNA H19 expression via the HIF-1α signaling pathway.

Cell Commun Signal 2018 11 20;16(1):84. Epub 2018 Nov 20.

Department of Anesthesiology, Gongli Hospital, the Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.

Background: Impaired wound healing frequently occurs in diabetes mellitus (DM) and is implicated in impaired angiogenesis. Long non-coding RNA (lncRNA) H19 has been reported as being reduced in DM and played a critical role in inducing angiogenesis. Thus, we hypothesized that H19 may affect impaired wound healing in streptozotocin (STZ)-induced diabetic mice transfused with autologous blood preserved in standard preservative fluid or modified preservative fluid. Read More

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http://dx.doi.org/10.1186/s12964-018-0290-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245761PMC
November 2018
1 Read

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia.

Cell Commun Signal 2018 11 20;16(1):83. Epub 2018 Nov 20.

Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.

Background: P2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in microglia is highly associated with microglial functions in controlling neuronal plasticity and brain homeostasis, we interested to explore the roles of P2X7 in mitochondrial and lysosomal functions as well as mitophagy in microglia.

Methods: P2X7 bone marrow-derived macrophages (BMDM), primary microglia and BV-2 immortalized microglial cells were used to detect the particular protein expression by immunoblotting. Read More

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http://dx.doi.org/10.1186/s12964-018-0293-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245559PMC
November 2018
11 Reads

Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation.

Cell Commun Signal 2018 11 16;16(1):82. Epub 2018 Nov 16.

Institute of Chemical Biology, School of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, China.

Background: Knockdown of Akt1 promotes Epithelial-to-Mesenchymal Transition in breast cancer cells. However, the mechanisms are not completely understood.

Methods: Western blotting, immunofluorescence, luciferase assay, real time PCR, ELISA and Matrigel invasion assay were used to investigate how Akt1 inhibition promotes breast cancer cell invasion in vitro. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0295-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240210PMC
November 2018
9 Reads
3.378 Impact Factor

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide.

Cell Commun Signal 2018 11 15;16(1):81. Epub 2018 Nov 15.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.

Background: Four-octyl itaconate (OI), the itaconate's cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (HO)-treated neuronal cells.

Methods: SH-SY5Y neuronal cells and epigenetically de-repressed (by TSA treatment) primary murine neurons were treated with OI and/or HO. Read More

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http://dx.doi.org/10.1186/s12964-018-0294-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238317PMC
November 2018
13 Reads

Correction to: Copper signalling: causes and consequences.

Cell Commun Signal 2018 11 12;16(1):80. Epub 2018 Nov 12.

Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary.

Following publication of the original article [1], the authors reported an error in Table 3. The correct version of Table 3 is shown below:The publishers apologise for this error. The original article [1] has been corrected. Read More

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http://dx.doi.org/10.1186/s12964-018-0292-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231271PMC
November 2018
10 Reads

Perspective on nanochannels as cellular mediators in different disease conditions.

Cell Commun Signal 2018 11 8;16(1):76. Epub 2018 Nov 8.

Brain Metastasis and NeuroVascular Disease Modeling Lab, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, NCR, India.

Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane components. These dynamic TNTs can form de novo in animal cells and establish complex intercellular networks between distant cells up to 150 μm apart. Within the last decade, TNTs have been discovered in different cell types including tumor cells, macrophages, monocytes, endothelial cells and T cells. Read More

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http://dx.doi.org/10.1186/s12964-018-0281-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222982PMC
November 2018
12 Reads

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.

Cell Commun Signal 2018 11 8;16(1):77. Epub 2018 Nov 8.

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Background: The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGFR. Here, we examine the impact of USP17 depletion on the growth, as well as EGFR endocytosis and signaling, of EGFR mutant (MT) NSCLC cells. Read More

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http://dx.doi.org/10.1186/s12964-018-0291-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225634PMC
November 2018
3 Reads

Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival.

Cell Commun Signal 2018 11 8;16(1):79. Epub 2018 Nov 8.

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.

Background: Insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while Nodal-ALK7-Smad3 signaling involves β-cells apoptosis. We attempted to address inter-relationship between Nodal and insulin in modulating β-cell proliferation and apoptosis.

Methods: Using INS-1 β-cells and isolated rat islets, we examined the effects of Nodal, insulin, or the two combined on β-cell proliferation and/or apoptosis. Read More

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http://dx.doi.org/10.1186/s12964-018-0288-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225724PMC
November 2018
4 Reads
3.380 Impact Factor

Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway.

Cell Commun Signal 2018 11 8;16(1):78. Epub 2018 Nov 8.

Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University Durham, 1801 Fayetteville St, Durham, NC, 27707, USA.

Background: Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis. Recent reports indicate that serotonin may promote tumor growth in liver cancer, however, the molecular mechanisms remain elusive. n this study, we investigated the role and molecular signaling mechanisms mediated by serotonin in liver cancer cell survival, drug resistance, and steatosis. Read More

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http://dx.doi.org/10.1186/s12964-018-0282-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225666PMC
November 2018
24 Reads

Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection.

Cell Commun Signal 2018 11 7;16(1):74. Epub 2018 Nov 7.

Department of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453, Witten, Germany.

Background: We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates canonical Wnt/β-catenin signaling. The localization of Lcn2-R in the inner medulla is intriguing considering local bacterial infections trigger toll-like receptor-4 (TLR-4)-mediated secretion of the bacteriostatic Fe-free (apo-)Lcn2.

Aim: To determine the effects of osmolarity/tonicity changes, Wnt/β-catenin and TLR-4 activation on Lcn2-R and Lcn2 expression and cell viability in rat primary IMCD and mouse (m)IMCD3 cells. Read More

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http://dx.doi.org/10.1186/s12964-018-0285-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223074PMC
November 2018
9 Reads

SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells.

Cell Commun Signal 2018 11 7;16(1):75. Epub 2018 Nov 7.

Epithelial Interactions in Cancer (EPIC), i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal.

Background: Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently overexpressed in these tumors, promoting cell invasion, stem cell activity and tumorigenesis by the activation of Src-Family kinase (SRC) signaling. Therefore, our aim was to evaluate if the treatment of BLBC cells with dasatinib, the FDA approved SRC inhibitor, would impact on P-cadherin induced tumor aggressive behavior. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0286-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223051PMC
November 2018
8 Reads

Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

Cell Commun Signal 2018 11 3;16(1):73. Epub 2018 Nov 3.

Department of Biotechnology and Health Science, Molecular Biotechnology Center, Università di Torino, Via Nizza 52, Torino, Italy.

Background: p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling. p130Cas has been shown to be highly expressed in a variety of human cancers of epithelial origin. However, few data are available regarding the role of p130Cas during normal epithelial development and homeostasis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0289-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215608PMC
November 2018
14 Reads
3.380 Impact Factor

WNK pathways in cancer signaling networks.

Cell Commun Signal 2018 11 3;16(1):72. Epub 2018 Nov 3.

Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX, 75390-9041, USA.

Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters.

Main Body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Read More

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http://dx.doi.org/10.1186/s12964-018-0287-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215617PMC
November 2018
1 Read
3.380 Impact Factor

Copper signalling: causes and consequences.

Cell Commun Signal 2018 10 22;16(1):71. Epub 2018 Oct 22.

Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary.

Copper-containing enzymes perform fundamental functions by activating dioxygen (O) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0277-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198518PMC
October 2018
6 Reads

Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland.

Cell Commun Signal 2018 10 22;16(1):70. Epub 2018 Oct 22.

College of Life Science and Bio-engineering, Beijing Molecular Hydrogen Research Center, Beijing University of Technology, Beijing, 100124, People's Republic of China.

Background: Benign Lymphoepithelial Lesion (BLEL) is a rare disease observed in the adult population. Despite the growing numbers of people suffering from BLEL, the etiology and mechanisms underlying its pathogenesis remain unknown.

Methods: In the present study, we used gene and cytokines expression profiling, western blot and immunohistochemistry to get further insight into the cellular and molecular mechanisms involved in the pathogenesis of BLEL of the lacrimal gland. Read More

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http://dx.doi.org/10.1186/s12964-018-0284-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196440PMC
October 2018
13 Reads

Transferrin receptor 1 is a supplementary receptor that assists transmissible gastroenteritis virus entry into porcine intestinal epithelium.

Cell Commun Signal 2018 10 20;16(1):69. Epub 2018 Oct 20.

College of Veterinary Medicine, Nanjing Agricultural University, Wei gang 1, Nanjing, Jiangsu, 210095, People's Republic of China.

Background: Transmissible gastroenteritis virus (TGEV), the etiologic agent of transmissible gastroenteritis, infects swine of all ages causing vomiting and diarrhea, in newborn piglets the mortality rate is near 100%. Intestinal epithelial cells are the primary target cells of TGEV. Transferrin receptor 1 (TfR1), which is highly expressed in piglets with anemia, may play a role in TGEV infection. Read More

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http://dx.doi.org/10.1186/s12964-018-0283-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196004PMC
October 2018
3 Reads

TRPV2-induced Ca-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Cell Commun Signal 2018 10 16;16(1):68. Epub 2018 Oct 16.

Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China.

Background: Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation. Nevertheless, the relationships between MBD and highly efficient stimuli of Ca in multiple myeloma (MM) progression, and possible regulatory mechanisms are poorly defined. Here, we reported that the nonselective cation channel transient receptor potential vanilloid 2 (TRPV2) plays a functional role in Ca oscillations and osteoclastogenesis. Read More

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http://dx.doi.org/10.1186/s12964-018-0280-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191893PMC
October 2018
3 Reads