525 results match your criteria Cell Communication and Signaling [Journal]


Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression.

Cell Commun Signal 2018 Jun 18;16(1):32. Epub 2018 Jun 18.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: To determine whether adipocyte-derived lipids could be transferred into breast cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty acid trafficking in breast cancer cells.

Methods: A Transwell co-culture system was used in which human breast cancer cells were cultured in the absence or presence of differentiated murine 3 T3-L1 adipocytes. Migration/invasion and proliferation abilities were compared between breast cancer cells that were cultivated alone and those co-cultivated with mature adipocytes. Read More

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Emerging roles and regulation of MiT/TFE transcriptional factors.

Cell Commun Signal 2018 Jun 15;16(1):31. Epub 2018 Jun 15.

Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China.

The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phosphorylation. And the phosphorylated protein is retained in the cytoplasm and subsequently translocates to the nucleus upon dephosphorylation, where it stimulates the expression of hundreds of genes, leading to lysosomal biogenesis and autophagy induction. Read More

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MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1.

Cell Commun Signal 2018 Jun 14;16(1):30. Epub 2018 Jun 14.

Department of Gastrointestinal Surgery and Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, Guilin, Guangxi, 541001, People's Republic of China.

In this study, we investigated the role of microRNA-644a (miR-644a) in the growth and survival of hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower in HCC tissues than in adjacent peri-cancerous tissues (n = 135). MiR-644a expression was inversely correlated with heat shock factor 1 (HSF1) expression, tumour diameter and TNM stage. Read More

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Disrupting SOD1 activity inhibits cell growth and enhances lipid accumulation in nasopharyngeal carcinoma.

Cell Commun Signal 2018 Jun 11;16(1):28. Epub 2018 Jun 11.

Department of Biochemistry and Molecular Biology, GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 510182, People's Republic of China.

Background: SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the SOD1 in the progress of NPC and underlying mechanisms remain unclear.

Methods: In NPC tissue samples, SOD1 protein levels were measured by Western blot and immunohistochemical (IHC) staining. Read More

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June 2018
2 Reads

Emerging roles of TRIO and F-actin-binding protein in human diseases.

Cell Commun Signal 2018 Jun 11;16(1):29. Epub 2018 Jun 11.

Department of Pharmacology, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.

TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP variants are broadly classified as variant-1 or - 4 and do not share exons. Read More

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SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior.

Cell Commun Signal 2018 Jun 8;16(1):27. Epub 2018 Jun 8.

Department of Surgery, Yale University School of Medicine, 333 Cedar Street, TMP FMB130A, P.O. Box 208062, New Haven, CT, 06520, USA.

Background: Altered expression of Solute Carrier Family 12 Member 7 (SLC12A7) is implicated to promote malignant behavior in multiple cancer types through an incompletely understood mechanism. Recent studies have shown recurrent gene amplifications and overexpression of SLC12A7 in adrenocortical carcinoma (ACC). The potential mechanistic effect(s) of SLC12A7 amplifications in portending an aggressive behavior in ACC has not been previously studied and is investigated here using two established ACC cell lines, SW-13 and NCI-H295R. Read More

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June 2018
2 Reads

Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.

Cell Commun Signal 2018 Jun 8;16(1):26. Epub 2018 Jun 8.

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, No.270 Dong'an Road, Xuhui District, Shanghai, 200032, China.

Background: Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer. Recent years have witnessed the importance of metabolism transformation in cancer cell malignancies maintenance. Aberrant cancer cell metabolism is considered to be the hallmark of cancer. Read More

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The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD).

Cell Commun Signal 2018 Jun 7;16(1):25. Epub 2018 Jun 7.

School of Life Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, China.

Background: Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fraction of cancer patients and the success makes PD-1 as a valuable target in immune checkpoint therapy. For the rational design of PD-1 targeting modulators, the ligand binding mechanism of PD-1 should be well understood in prior. Read More

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June 2018
3 Reads

Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones.

Cell Commun Signal 2018 May 29;16(1):24. Epub 2018 May 29.

Platelet Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health and Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley Campus, Office 160, Building 305, Kent Street, Bentley, Perth, WA, 6102, Australia.

Background: The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens. Recently it became clear that NETs are also released in pathological conditions. NETs released in the blood can activate thrombosis and initiate a cascade of platelet responses. Read More

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Casein kinase 1α: biological mechanisms and theranostic potential.

Cell Commun Signal 2018 May 24;16(1):23. Epub 2018 May 24.

Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, 310016, Hangzhou, China.

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1α is a promising therapeutic target. Read More

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High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo.

Cell Commun Signal 2018 May 21;16(1):22. Epub 2018 May 21.

Department of Pathology, Dalian Medical University, Key Laboratory for Tumor Metastasis and Intervention of Liaoning Province, 9 West, Lvshun Southern Road, Dalian, 116044, Liaoning, China.

Background: SDF1/CXCR4 and AnnexinA7 play important roles in many physiological and pathological conditions, but the molecular association between them in cancer cells has not been studied thus far.

Methods: The expression changes of SDF1/CXCR4 were detected by gene transcriptome sequencing, qRT-PCR, Western blotting, cytoimmunofluorescence and immunohistochemistry in mouse hepatocarcinoma F/P cells, AnnexinA7 downregulated expression F (F) cells, AnnexinA7 overexpression P (P) cells, AnnexinA7 unrelated sequence F (F) cells, empty vector P (P) cells and normal liver cells in vitro and in vivo.

Results: SDF1 and CXCR4 were co-expressed in hepatocarcinoma cells. Read More

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May 2018
5 Reads

The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling.

Cell Commun Signal 2018 May 18;16(1):21. Epub 2018 May 18.

Department of General Pediatrics, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

Background: The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for anti-cancer activity in Ewing sarcoma, a rare and aggressive cancer of bone and soft tissues.

Methods: We used a variety of methods such as cell viability and migration assays, flow cytometry, phospho-tyrosine arrays and western blotting to determine plerixafor effects on five characterized Ewing sarcoma cell lines and a low-passage culture in vitro. Read More

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Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.

Cell Commun Signal 2018 May 2;16(1):20. Epub 2018 May 2.

Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, TS, 500046, India.

Background: Histone deacetylases (HDACs) are involved in epigenetic gene regulation via deacetylation of acetylated lysine residues of both histone and non-histone proteins. Among the 18 HDACs identified in humans, HDAC8, a class I HDAC, is best understood structurally and enzymatically. However, its precise subcellular location, function in normal cellular physiology, its protein partners and substrates still remain elusive. Read More

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May 2018
2 Reads

Golgi tethering factor golgin-97 suppresses breast cancer cell invasiveness by modulating NF-κB activity.

Cell Commun Signal 2018 Apr 27;16(1):19. Epub 2018 Apr 27.

Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer remains unclear.

Methods: We searched for a potential role of golgin-97 in cancers using Kaplan-Meier Plotter ( http://kmplot. Read More

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YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts.

Cell Commun Signal 2018 Apr 25;16(1):18. Epub 2018 Apr 25.

Department of Dermatology, University of Michigan Medical School, 1301 Catherine, Medical Science I, Room 6447, Ann Arbor, MI, 48109-0609, USA.

Background: Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact of YAP and TAZ levels on the TGF-β/Smad signaling pathway in human skin dermal fibroblasts. Read More

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Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages.

Cell Commun Signal 2018 Apr 24;16(1):17. Epub 2018 Apr 24.

Faculty of Medicine, University of Latvia, Raina blvd. 19, Riga, LV-1568, Latvia.

Background: Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influence cancer progression and patient survival. Extracellular vesicles (EVs) are membrane-bound vesicles containing different biomolecules that are involved in cell to cell signal transfer. Read More

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miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT.

Cell Commun Signal 2018 Apr 16;16(1):16. Epub 2018 Apr 16.

Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Dadao, Wuhan, 430030, People's Republic of China.

Background: Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis.

Methods: miRNA microarray analysis and real-time PCR were used to determine the miRNA expression profiles in a cohort of 69 clinical samples including 50 CD117/KIT GISTs and 19 CD117/wild-type GISTs. Read More

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April 2018
1 Read

Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis.

Cell Commun Signal 2018 Apr 11;16(1):15. Epub 2018 Apr 11.

Centro de Envejecimiento y Regeneración UC (CARE UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, PO Box 114-D, Santiago, Chile.

Background: In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonical pathways. In the canonical pathway, the binding of canonical ligands such as Wnt3a to the Frizzled receptor induces inactivation of glycogen synthase kinase-3β (GSK-3β), which stabilizes β-catenin and allows its translocation to the nucleus. Read More

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April 2018
1 Read

Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells.

Cell Commun Signal 2018 Apr 10;16(1):14. Epub 2018 Apr 10.

Institute of Immunology, Centre of Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58448, Witten, Germany.

Background: In addition to physiological events such as fertilisation, placentation, osteoclastogenesis, or tissue regeneration/wound healing, cell fusion is involved in pathophysiological conditions such as cancer. Cell fusion, which applies to both the proteins and conditions that induce the merging of two or more cells, is not a fully understood process. Inflammation/pro-inflammatory cytokines might be a positive trigger for cell fusion. Read More

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April 2018
1 Read

Interaction between human osteosarcoma and mesenchymal stem cells via an interleukin-8 signaling loop in the tumor microenvironment.

Cell Commun Signal 2018 Apr 6;16(1):13. Epub 2018 Apr 6.

Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, 879-5593, Japan.

Background: Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly influenced not only by characteristics of the tumor itself, but also by the surrounding microenvironment. In other words, OS is considered to utilize cells in the vicinity of the tumor by changing the characteristics of these cells. Read More

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April 2018
1 Read

The nuclear transportation routes of membrane-bound transcription factors.

Cell Commun Signal 2018 Apr 3;16(1):12. Epub 2018 Apr 3.

Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, 410013, Hunan, China.

Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are anchored in membranes in a dormant state. Activated by external or internal stimuli, MTFs are released from parent membranes and are transported to the nucleus. Existing research indicates that some plasma membrane (PM)-bound proteins and some endoplasmic reticulum (ER) membrane-bound proteins have the ability to enter the nucleus. Read More

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April 2018
1 Read

A highlight on Sonic hedgehog pathway.

Cell Commun Signal 2018 Mar 20;16(1):11. Epub 2018 Mar 20.

Laboratorio de Biomedicina do Cérebro, Instituto Estadual do Cérebro Paulo Niemeyer (IECPN), Secretaria de Estado de Saúde, Rua do Rezende 156, Centro, Rio de Janeiro, CEP: 20230-024, Brazil.

Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors. Most of the brain tumors are resistant to chemotherapeutic drugs, consequently, they have a poor prognosis. Read More

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March 2018
2 Reads

Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1.

Cell Commun Signal 2018 Mar 13;16(1):10. Epub 2018 Mar 13.

Department of Surgery (RMH), The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, 3010, Australia.

Background: Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how these two pathways interact with each other is controversial. Read More

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March 2018
1 Read

Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells.

Cell Commun Signal 2018 Mar 12;16(1). Epub 2018 Mar 12.

Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

Background: The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances its nuclear translocation. Nuclear beta-catenin function is regulated by transcriptional co-factors such as CREB binding protein (CBP) and p300. Read More

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March 2018
1 Read

HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer.

Cell Commun Signal 2018 Feb 20;16(1). Epub 2018 Feb 20.

The Clinical Medical Testing Laboratory, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, 225001, China.

Background: High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown.

Methods: We investigated HMGB2 expression in 185 cases of primary breast cancer and matched normal breast tissue specimens, and explored the underlying mechanisms of altered HMGB2 expression as well as the impact of this altered expression on breast cancer growth and on aerobic glycolysis using in vitro and animal models of breast cancer. Read More

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February 2018
4 Reads

Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway.

Cell Commun Signal 2018 Feb 20;16(1). Epub 2018 Feb 20.

Department of Medicine, Division of Hematology-Oncology, University of Pittsburgh, Pittsburgh, PA, USA.

Background: 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal Medicine (TCM) has been shown to enhance the efficacy of standard anticancer agents. Read More

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February 2018
3 Reads

Oxidative phosphorylation activation is an important characteristic of DOX resistance in hepatocellular carcinoma cells.

Cell Commun Signal 2018 Feb 5;16(1). Epub 2018 Feb 5.

Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.

Background: Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear.

Methods: To analyze differences between cell types, cell viability, ATP and α-ketoglutaric acid levels, the oxygen consumption rate and extracellular acidification rate, and the expression of key enzymes involved in α-KG metabolism and transfer were examined. Additionally, UPLC-MS/MS was used to determine the doxorubicin (DOX) content in SMMC-7721 and SMMC-7721/DOX cells. Read More

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February 2018
5 Reads

LncRNA HOTAIR promotes cell migration and invasion by regulating MKL1 via inhibition miR206 expression in HeLa cells.

Cell Commun Signal 2018 Feb 1;16(1). Epub 2018 Feb 1.

College of Life Science and Healthy, Wuhan University of Science and technology, Wuhan, 430065, China.

Background: Long non-coding RNAs (lncRNAs) have emerged as a new and crucial layer of gene regulation in recent years and regulate various biological processes such as carcinogenesis and metastasis. LncRNA HOTAIR, an oncogenic lncRNA, is involved in human tumorigenesis and dysregulated in cervical cancer. Megakaryoblastic leukemia 1 (MKL1), as a transcription coactivity factor, involved in cancer metastasis and cell differentiation. Read More

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February 2018
3 Reads

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model.

Cell Commun Signal 2018 Jan 5;16(1). Epub 2018 Jan 5.

Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRKD2, EPB41L5, paxillin, and cortactin. Components of this pathway are often overexpressed in human breast cancer cells, to be correlated with poor prognosis of the patients, whereas overexpression of the Arf6 pathway did not correlate with the four main molecular classes of human breast tumors. In this pathway, receptor tyrosine kinases, including EGFR and Her2, activate Arf6 via GEP100. Read More

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January 2018
6 Reads

Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC).

Cell Commun Signal 2018 Jan 5;16(1). Epub 2018 Jan 5.

Biochemistry and Tumor Biology Laboratory, Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, D-30625, Germany.

Background: Fusion of breast cancer cells with tumor-associated populations of the microenvironment including mesenchymal stroma/stem-like cells (MSC) represents a rare event in cell communication whereby the metastatic capacity of those hybrid cells remains unclear.

Methods: Functional changes were investigated in vitro and in vivo following spontaneous fusion and hybrid cell formation between primary human MSC and human MDA-MB-231 breast cancer cells. Thus, lentiviral eGFP-labeled MSC and breast cancer cells labeled with mcherry resulted in dual-fluorescing hybrid cells after co-culture. Read More

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January 2018
3 Reads

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer.

Cell Commun Signal 2018 Jan 8;16(1). Epub 2018 Jan 8.

Department of Biosciences, COMSATS Institute of Information Technology, Park Road, Islamabad, Zip code: 44000, Pakistan.

Background: Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are explored in the study.

Method: One hundred fifty fresh tumours of breast cancer patients were collected for the study. Read More

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January 2018
3 Reads

Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis.

Cell Commun Signal 2018 Jan 10;16(1). Epub 2018 Jan 10.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, 30 bd J. Monnet, 44093, Nantes, France.

Background: Notch signaling controls many cellular processes, including cell fate determination, cell differentiation, proliferation and apoptosis. In mammals, four Notch receptors (Notch 1-4) can interact with five distinct ligands [Jagged1, Jagged2, Delta-like 1 (DLL1), DLL3, and DLL4]. We previously reported that Notch activation is modulated in endothelial cells and monocytes during inflammation and showed that inflammation upregulates DLL4 on endothelial cells. Read More

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January 2018
7 Reads

MicroRNA-135a regulates NHE9 to inhibit proliferation and migration of glioblastoma cells.

Cell Commun Signal 2017 12 21;15(1):55. Epub 2017 Dec 21.

Department of Natural Sciences, University of Michigan-Dearborn, 4901 Evergreen Road, SFC # 207, Dearborn, MI, 48128, USA.

Background: Glioblastoma multiformae (GBM) is the most aggressive type of malignant brain tumor with complex molecular profile. Overexpression of Na/H Exchanger isoform 9 (NHE9) promotes tumor progression and correlates positively with insensitivity to radiochemotherapy and poor prognosis. However, molecular mechanisms responsible for increase in NHE9 levels beyond a critical threshold have not been identified. Read More

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December 2017
5 Reads

A functional role of LEFTY during progesterone therapy for endometrial carcinoma.

Cell Commun Signal 2017 12 21;15(1):56. Epub 2017 Dec 21.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Background: The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role in endometrial carcinomas (Em Cas). Herein, we focused on LEFTY expression and its association with progesterone therapy in Em Cas.

Methods: Regulation and function of LEFTY, as well as its associated molecules including Smad2, ovarian hormone receptors, GSK-3β, and cell cycle-related factors, were assessed using clinical samples and cell lines of Em Cas. Read More

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December 2017
6 Reads

NFAT1-regulated IL6 signalling contributes to aggressive phenotypes of glioma.

Cell Commun Signal 2017 Dec 19;15(1):54. Epub 2017 Dec 19.

Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping District, Shenyang, 110001, China.

Background: We previously demonstrated that the local immune status correlated with the glioma prognosis. Interleukin-6 (IL6) was identified as an important local immune-related risk marker related to unfavourable prognosis. In this study, we further investigated the role and regulation of IL6 signalling in glioma. Read More

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December 2017
4 Reads

Predictive model identifies strategies to enhance TSP1-mediated apoptosis signaling.

Cell Commun Signal 2017 Dec 19;15(1):53. Epub 2017 Dec 19.

Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.

Background: Thrombospondin-1 (TSP1) is a matricellular protein that functions to inhibit angiogenesis. An important pathway that contributes to this inhibitory effect is triggered by TSP1 binding to the CD36 receptor, inducing endothelial cell apoptosis. However, therapies that mimic this function have not demonstrated clear clinical efficacy. Read More

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December 2017
3 Reads

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.

Cell Commun Signal 2017 Dec 16;15(1):52. Epub 2017 Dec 16.

Taishan Scholar Immunology Program, School of Basic Medical Sciences, Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China.

Background: Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate (IMP) cyclohydrolase (ATIC), a bifunctional protein enzyme, catalyzes the last two steps of the de novo purine biosynthetic pathway. Read More

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December 2017
4 Reads

Adaptive phenotype drives resistance to androgen deprivation therapy in prostate cancer.

Cell Commun Signal 2017 Dec 8;15(1):51. Epub 2017 Dec 8.

Academic Unit of Medical Oncology, Ospedale Policlinico San Martino, L.go R. Benzi 10, 16132, Genoa, Italy.

Background: Prostate cancer (PCa), the second most common cancer affecting men worldwide, shows a broad spectrum of biological and clinical behaviour representing the epiphenomenon of an extreme heterogeneity. Androgen deprivation therapy is the mainstay of treatment for advanced forms but after few years the majority of patients progress to castration-resistant prostate cancer (CRPC), a lethal form that poses considerable therapeutic challenges.

Methods: Western blotting, immunocytochemistry, invasion and reporter assays, and in vivo studies were performed to characterize androgen resistant sublines phenotype in comparison to the parental cell line LNCaP. Read More

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December 2017
6 Reads

Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription.

Cell Commun Signal 2017 Nov 29;15(1):50. Epub 2017 Nov 29.

Laboratorio de Oncología Molecular y TGFβ, Instituto Murciano de Investigaciones Biosanitarias Arrixaca, El Palmar, Murcia, Spain.

Background: The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad proteins, TGFβ signaling intracellular transducers, object of post-translational modifications that modulate TGFβ-dependent transcription. Protein acetylation is emerging as a compelling mechanism affecting the activities of significant transcription factors, including p53, FOXO or NF-kB. Read More

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November 2017
5 Reads

Correction to: A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.

Cell Commun Signal 2017 11 27;15(1):49. Epub 2017 Nov 27.

College of Life Science, Liaoning Normal University, Dalian, 116081, China.

Correction: Unfortunately, following publication of this article [1], it was noticed that the key in Figure 5c incorrectly showed '0 h', '5 h' and '10 h'. The corrected version, showing '0 h', '12 h' and '24 h', can be seen below and the original article has been updated to reflect this. Read More

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November 2017
11 Reads

Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities.

Cell Commun Signal 2017 Nov 14;15(1):48. Epub 2017 Nov 14.

Atlantic Cancer Research Institute, 35 Providence Street, Moncton, NB, E1C 8X3, Canada.

Background: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space where it synthesizes intracellular HA. HA is a ubiquitous glycosaminoglycan, mainly present in the extracellular matrix (ECM) and on the cell surface, but are also detected intracellularly. Read More

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November 2017
4 Reads

Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Cell Commun Signal 2017 Nov 13;15(1):47. Epub 2017 Nov 13.

Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.

Background: One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not been fully clarified.

Methods: We studied the effects of the therapeutic dose of tacrolimus on mitochondrial fitness in beta-cells. Read More

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November 2017
3 Reads
3 PubMed Central Citations(source)
3.38 Impact Factor

A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication.

Cell Commun Signal 2017 Nov 13;15(1):46. Epub 2017 Nov 13.

Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Mayo Mail Code 480, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.

Background: Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system designed to test the effects of intercellular transfer of a therapeutic oncolytic virus, and viral-activated drugs, between cells via TNTs. Read More

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November 2017
3 Reads

CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion.

Cell Commun Signal 2017 Nov 9;15(1):45. Epub 2017 Nov 9.

Department of Obstetrics and Gynecology, Louisiana State University, Health Sciences Center, New Orleans, USA.

Background: We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling pathways. In the present study, we identified CD146 as a potential novel target, negatively regulated by CD44. While the exact function of CD146 in breast cancer (BC) is not completely understood, substantial evidence from our work and others support the hypothesis that CD146 is a suppressor of breast tumor progression. Read More

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November 2017
5 Reads

Metabolic shift in density-dependent stem cell differentiation.

Cell Commun Signal 2017 Oct 20;15(1):44. Epub 2017 Oct 20.

Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 2500 North Lake Road, Merced, CA, 95343, USA.

Background: Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions from mouse ESCs using our staged and chemically-defined induction methods, we found that cell seeding density but not VEGF treatment between 10 ng/mL and 40 ng/mL was a significant variable directing ESCs into FLK1 VPCs during stage 1 induction. Here, we examine potential contributions from cell-to-cell signaling or cellular metabolism in the production of VPCs from ESCs seeded at different cell densities. Read More

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October 2017
3 Reads

Human umbilical cord Wharton jelly cells promote extra-pancreatic insulin formation and repair of renal damage in STZ-induced diabetic mice.

Cell Commun Signal 2017 Oct 17;15(1):43. Epub 2017 Oct 17.

Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.

Background: We evaluated the therapeutic effect and fate of high doses of human umbilical cord Wharton jelly cells (hUCWJCs) after IP administration to streptozotocin (STZ)-induced diabetic mice.

Methods: Type 1 diabetes (T1D) was induced in Kunming mice via IP injection of STZ. hUCWJCs were labeled with 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI). Read More

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October 2017
5 Reads

A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.

Cell Commun Signal 2017 Oct 16;15(1):42. Epub 2017 Oct 16.

College of Life Science, Liaoning Normal University, Dalian, 116081, China.

Background: In previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but the protein with cytocidal activity was unidentified.

Methods: A novel lamprey immune protein (LIP) as defense molecule was first purified and identified in jawless vertebrates (cyclostomes) using hydroxyapatite column and Q Sepharose Fast Flow column. After LIP stimulation, morphological changes of tumor cells were analysed and measured whether in vivo or in vitro. Read More

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October 2017
7 Reads

DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.

Cell Commun Signal 2017 Oct 10;15(1):41. Epub 2017 Oct 10.

Cold Spring Harbor Laboratory, New York, USA.

Fanconi Anemia (FA) is a rare, inherited genomic instability disorder, caused by mutations in genes involved in the repair of interstrand DNA crosslinks (ICLs). The FA signaling network contains a unique nuclear protein complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. FA proteins act at different steps of ICL repair in sensing, recognition and processing of DNA lesions. Read More

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October 2017
16 Reads

Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4.

Cell Commun Signal 2017 Oct 10;15(1):40. Epub 2017 Oct 10.

Clinic of Urology, Pediatric Urology and Andrology, Justus-Liebig-University Giessen, Rudolf-Buchheim-Str. 7, 35392, Giessen, Germany.

Background: Human cancer cells often exhibit impaired IGF2 expression and the underlying mechanisms are multifaceted and complex. Besides the well-known imprinting control region IGF2/H19-ICR, the involvement of a differentially methylated region in the promoter P0 of IGF2 gene (IGF2-DMR0) has been suggested. Here, we evaluate several mechanisms potentially leading to up- and/or down-regulation of IGF2 expression in prostate cancer and present a novel role of Kruppel-like factor 4 (KLF4) as a transcriptional regulator of IGF2 binding in IGF2-DMR0. Read More

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October 2017
8 Reads

NF-κB potentiates tumor growth by suppressing a novel target LPTS.

Cell Commun Signal 2017 Oct 10;15(1):39. Epub 2017 Oct 10.

Department of Biochemistry and Molecular Biology, Third Military Medical University, Chongqing, 400038, China.

Background: Chronic inflammation is causally linked to the carcinogenesis and progression of most solid tumors. LPTS is a well-identified tumor suppressor by inhibiting telomerase activity and cancer cell growth. However, whether and how LPTS is regulated by inflammation signaling is still incompletely elucidated. Read More

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October 2017
9 Reads