592 results match your criteria Cell Communication and Signaling [Journal]


Blockade of ARHGAP11A reverses malignant progress via inactivating Rac1B in hepatocellular carcinoma.

Cell Commun Signal 2018 Dec 13;16(1):99. Epub 2018 Dec 13.

Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background: The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of currently known targets has not yet led to successful clinical outcome. More understanding about the regulatory mechanisms in HCC is necessary for developing new effective therapeutic strategies for HCC patients. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0312-4DOI Listing
December 2018
1 Read

Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.

Cell Commun Signal 2018 Dec 12;16(1):98. Epub 2018 Dec 12.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.

Background: Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.

Methods: Using single receptor-deficient platelets from TAM knockout mice in the C57BL/6 J strain, we performed a knockout study using single TAM-deficient mice. Read More

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http://dx.doi.org/10.1186/s12964-018-0308-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291976PMC
December 2018

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle.

Cell Commun Signal 2018 Dec 7;16(1):97. Epub 2018 Dec 7.

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by the loss of muscle strength and mass, is one of the pathological conditions regulated by TGF-β1, but the underlying mechanism involved in the atrophic effects of TGF-β1 is not fully understood.

Methods: Mice sciatic nerve transection model was created and gastrocnemius were analysed by western blot, immunofluorescence staining and fibre diameter quantification after 2 weeks. Read More

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http://dx.doi.org/10.1186/s12964-018-0310-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286536PMC
December 2018

bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling.

Cell Commun Signal 2018 Dec 5;16(1):96. Epub 2018 Dec 5.

Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich Heine University, Düsseldorf, Germany.

Background: Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. Read More

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http://dx.doi.org/10.1186/s12964-018-0307-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282345PMC
December 2018
1 Read

Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.

Cell Commun Signal 2018 Dec 5;16(1):95. Epub 2018 Dec 5.

Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, 150040, People's Republic of China.

Background: The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. Jumeau (Jumu) is a member of the winged-helix/forkhead (FKH) transcription factor family and is required for Drosophila development. Adult jumu mutant flies show defective hemocyte phagocytosis and a weaker defense capability against pathogen infection. Read More

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http://dx.doi.org/10.1186/s12964-018-0305-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280549PMC
December 2018
1 Read

Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice.

Cell Commun Signal 2018 Dec 3;16(1):93. Epub 2018 Dec 3.

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFRα in non-cancerous hepatocytes and liver fibrosis is unclear. Read More

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http://dx.doi.org/10.1186/s12964-018-0306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276164PMC
December 2018
1 Read

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.

Cell Commun Signal 2018 Dec 4;16(1):94. Epub 2018 Dec 4.

Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-driven cell-invasive phenotype. We found that AMAP1 levels are under the control of p53 (TP53 gene product) in epithelial cells but not in fibroblasts, and here addressed that molecular basis of the epithelial-specific function of p53 in suppressing invasiveness via targeting AMAP1. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0302-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278066PMC
December 2018
3 Reads

Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes.

Cell Commun Signal 2018 Nov 29;16(1):91. Epub 2018 Nov 29.

Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, Heilongjiang Province, China.

Background: The link between cardiac diseases and cognitive deterioration has been accepted from the concept of "cardiogenic dementia", which was proposed in the late 1970s. However, the molecular mechanism is unclarified.

Methods: The two animal models used in this study were cardiac-specific overexpression of microRNA-1-2 transgenic (Tg) mice and a myocardial infarction mouse model generated by left coronary artery ligation (LCA). Read More

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http://dx.doi.org/10.1186/s12964-018-0303-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267908PMC
November 2018
1 Read

Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.

Cell Commun Signal 2018 Nov 29;16(1):92. Epub 2018 Nov 29.

Department of General Surgery, the Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, China.

Background: Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (TNBC) to chemotherapy remains a major clinical problem. Our previous study demonstrated that the expression levels of PTN and its receptor PTPRZ1 were upregulated in recurrent TNBC tissue after chemotherapy, and this increase was closely related to poor prognosis in those patients. Read More

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http://dx.doi.org/10.1186/s12964-018-0304-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267809PMC
November 2018

Correction to: Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

Cell Commun Signal 2018 Nov 26;16(1):90. Epub 2018 Nov 26.

Department of Biotechnology and Health Science, Molecular Biotechnology Center, Università di Torino, Via Nizza, 52, Torino, Italy.

Following publication of the original article [1], the authors reported an error in the name of the 11th author. The author's name was incorrectly published as "Vincenzo Calautti", instead of "Enzo Calautti". Read More

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http://dx.doi.org/10.1186/s12964-018-0296-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258440PMC
November 2018

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis.

Cell Commun Signal 2018 Nov 23;16(1):89. Epub 2018 Nov 23.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Hankou Road 22, Nanjing, 210093, China.

Background: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident mesenchymal stem cells (LR-MSCs) have been identified as an important contributor to myofibroblast activation in pulmonary fibrosis. Macrophages are also believed to play a critical role in pulmonary fibrosis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0300-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260991PMC
November 2018
3 Reads
3.380 Impact Factor

SOX2 as a novel contributor of oxidative metabolism in melanoma cells.

Cell Commun Signal 2018 Nov 22;16(1):87. Epub 2018 Nov 22.

Department of Clinical and Experimental Biomedical Sciences "Mario Serio", Section of Experimental Pathology and Oncology, University of Florence, Viale G.B. Morgagni, 50, 50134, Florence, Italy.

Background: Deregulated metabolism is a hallmark of cancer and recent evidence underlines that targeting tumor energetics may improve therapy response and patient outcome. Despite the general attitude of cancer cells to exploit the glycolytic pathway even in the presence of oxygen (aerobic glycolysis or "Warburg effect"), tumor metabolism is extremely plastic, and such ability to switch from glycolysis to oxidative phosphorylation (OxPhos) allows cancer cells to survive under hostile microenvironments. Recently, OxPhos has been related with malignant progression, chemo-resistance and metastasis. Read More

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http://dx.doi.org/10.1186/s12964-018-0297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249961PMC
November 2018
3 Reads

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

Cell Commun Signal 2018 Nov 22;16(1):88. Epub 2018 Nov 22.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Background: Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer cells in the same microenvironment appear not to be affected. Mechanisms whereby cancer cells resist accelerated tryptophan degradation are not completely understood. Read More

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http://dx.doi.org/10.1186/s12964-018-0301-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251197PMC
November 2018

Regulation of MRTF-A by JMY via a nucleation-independent mechanism.

Cell Commun Signal 2018 Nov 21;16(1):86. Epub 2018 Nov 21.

Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg, 06114, Halle (Saale), Germany.

Background: MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression. The activity of MRTF-A is critically dependent on the dissociation of G-actin from N-terminal RPEL motifs. MRTF-SRF induction often correlates with enhanced polymerization of F-actin. Read More

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http://dx.doi.org/10.1186/s12964-018-0299-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249979PMC
November 2018
7 Reads

Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism.

Cell Commun Signal 2018 Nov 20;16(1):85. Epub 2018 Nov 20.

Department of Chemical Engineering, Bogazici University, Istanbul, Turkey.

Background: Rapamycin is a potent inhibitor of the highly conserved TOR kinase, the nutrient-sensitive controller of growth and aging. It has been utilised as a chemotherapeutic agent due to its anti-proliferative properties and as an immunosuppressive drug, and is also known to extend lifespan in a range of eukaryotes from yeast to mammals. However, the mechanisms through which eukaryotic cells adapt to sustained exposure to rapamycin have not yet been thoroughly investigated. Read More

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http://dx.doi.org/10.1186/s12964-018-0298-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245637PMC
November 2018
2 Reads

Autologous blood transfusion augments impaired wound healing in diabetic mice by enhancing lncRNA H19 expression via the HIF-1α signaling pathway.

Cell Commun Signal 2018 Nov 20;16(1):84. Epub 2018 Nov 20.

Department of Anesthesiology, Gongli Hospital, the Second Military Medical University, No. 219, Miaopu Road, Pudong New Area, Shanghai, 200135, People's Republic of China.

Background: Impaired wound healing frequently occurs in diabetes mellitus (DM) and is implicated in impaired angiogenesis. Long non-coding RNA (lncRNA) H19 has been reported as being reduced in DM and played a critical role in inducing angiogenesis. Thus, we hypothesized that H19 may affect impaired wound healing in streptozotocin (STZ)-induced diabetic mice transfused with autologous blood preserved in standard preservative fluid or modified preservative fluid. Read More

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http://dx.doi.org/10.1186/s12964-018-0290-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245761PMC
November 2018

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia.

Cell Commun Signal 2018 Nov 20;16(1):83. Epub 2018 Nov 20.

Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.

Background: P2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in microglia is highly associated with microglial functions in controlling neuronal plasticity and brain homeostasis, we interested to explore the roles of P2X7 in mitochondrial and lysosomal functions as well as mitophagy in microglia.

Methods: P2X7 bone marrow-derived macrophages (BMDM), primary microglia and BV-2 immortalized microglial cells were used to detect the particular protein expression by immunoblotting. Read More

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http://dx.doi.org/10.1186/s12964-018-0293-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245559PMC
November 2018
4 Reads

Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation.

Cell Commun Signal 2018 Nov 16;16(1):82. Epub 2018 Nov 16.

Institute of Chemical Biology, School of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, China.

Background: Knockdown of Akt1 promotes Epithelial-to-Mesenchymal Transition in breast cancer cells. However, the mechanisms are not completely understood.

Methods: Western blotting, immunofluorescence, luciferase assay, real time PCR, ELISA and Matrigel invasion assay were used to investigate how Akt1 inhibition promotes breast cancer cell invasion in vitro. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0295-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240210PMC
November 2018
2 Reads
3.378 Impact Factor

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide.

Cell Commun Signal 2018 Nov 15;16(1):81. Epub 2018 Nov 15.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.

Background: Four-octyl itaconate (OI), the itaconate's cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (HO)-treated neuronal cells.

Methods: SH-SY5Y neuronal cells and epigenetically de-repressed (by TSA treatment) primary murine neurons were treated with OI and/or HO. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0294-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238317PMC
November 2018
6 Reads

Correction to: Copper signalling: causes and consequences.

Cell Commun Signal 2018 Nov 12;16(1):80. Epub 2018 Nov 12.

Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary.

Following publication of the original article [1], the authors reported an error in Table 3. The correct version of Table 3 is shown below:The publishers apologise for this error. The original article [1] has been corrected. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0292-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231271PMC
November 2018
3 Reads

Perspective on nanochannels as cellular mediators in different disease conditions.

Cell Commun Signal 2018 Nov 8;16(1):76. Epub 2018 Nov 8.

Brain Metastasis and NeuroVascular Disease Modeling Lab, Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, NCR, India.

Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane components. These dynamic TNTs can form de novo in animal cells and establish complex intercellular networks between distant cells up to 150 μm apart. Within the last decade, TNTs have been discovered in different cell types including tumor cells, macrophages, monocytes, endothelial cells and T cells. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0281-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222982PMC
November 2018
6 Reads

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.

Cell Commun Signal 2018 Nov 8;16(1):77. Epub 2018 Nov 8.

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Background: The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGFR. Here, we examine the impact of USP17 depletion on the growth, as well as EGFR endocytosis and signaling, of EGFR mutant (MT) NSCLC cells. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0291-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225634PMC
November 2018
2 Reads

Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival.

Cell Commun Signal 2018 Nov 8;16(1):79. Epub 2018 Nov 8.

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.

Background: Insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while Nodal-ALK7-Smad3 signaling involves β-cells apoptosis. We attempted to address inter-relationship between Nodal and insulin in modulating β-cell proliferation and apoptosis.

Methods: Using INS-1 β-cells and isolated rat islets, we examined the effects of Nodal, insulin, or the two combined on β-cell proliferation and/or apoptosis. Read More

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http://dx.doi.org/10.1186/s12964-018-0288-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225724PMC
November 2018
3 Reads
3.380 Impact Factor

Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway.

Cell Commun Signal 2018 Nov 8;16(1):78. Epub 2018 Nov 8.

Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University Durham, 1801 Fayetteville St, Durham, NC, 27707, USA.

Background: Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis. Recent reports indicate that serotonin may promote tumor growth in liver cancer, however, the molecular mechanisms remain elusive. n this study, we investigated the role and molecular signaling mechanisms mediated by serotonin in liver cancer cell survival, drug resistance, and steatosis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0282-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225666PMC
November 2018
8 Reads

Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection.

Cell Commun Signal 2018 Nov 7;16(1):74. Epub 2018 Nov 7.

Department of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), D-58453, Witten, Germany.

Background: We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates canonical Wnt/β-catenin signaling. The localization of Lcn2-R in the inner medulla is intriguing considering local bacterial infections trigger toll-like receptor-4 (TLR-4)-mediated secretion of the bacteriostatic Fe-free (apo-)Lcn2.

Aim: To determine the effects of osmolarity/tonicity changes, Wnt/β-catenin and TLR-4 activation on Lcn2-R and Lcn2 expression and cell viability in rat primary IMCD and mouse (m)IMCD3 cells. Read More

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http://dx.doi.org/10.1186/s12964-018-0285-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223074PMC
November 2018
6 Reads

SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells.

Cell Commun Signal 2018 Nov 7;16(1):75. Epub 2018 Nov 7.

Epithelial Interactions in Cancer (EPIC), i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135, Porto, Portugal.

Background: Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently overexpressed in these tumors, promoting cell invasion, stem cell activity and tumorigenesis by the activation of Src-Family kinase (SRC) signaling. Therefore, our aim was to evaluate if the treatment of BLBC cells with dasatinib, the FDA approved SRC inhibitor, would impact on P-cadherin induced tumor aggressive behavior. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0286-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223051PMC
November 2018
4 Reads

Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

Cell Commun Signal 2018 Nov 3;16(1):73. Epub 2018 Nov 3.

Department of Biotechnology and Health Science, Molecular Biotechnology Center, Università di Torino, Via Nizza 52, Torino, Italy.

Background: p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling. p130Cas has been shown to be highly expressed in a variety of human cancers of epithelial origin. However, few data are available regarding the role of p130Cas during normal epithelial development and homeostasis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0289-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215608PMC
November 2018
6 Reads
3.380 Impact Factor

WNK pathways in cancer signaling networks.

Cell Commun Signal 2018 Nov 3;16(1):72. Epub 2018 Nov 3.

Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX, 75390-9041, USA.

Background: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters.

Main Body: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes. Read More

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http://dx.doi.org/10.1186/s12964-018-0287-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215617PMC
November 2018
3.380 Impact Factor

Copper signalling: causes and consequences.

Cell Commun Signal 2018 Oct 22;16(1):71. Epub 2018 Oct 22.

Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary.

Copper-containing enzymes perform fundamental functions by activating dioxygen (O) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0277-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198518PMC
October 2018
5 Reads

Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland.

Cell Commun Signal 2018 Oct 22;16(1):70. Epub 2018 Oct 22.

College of Life Science and Bio-engineering, Beijing Molecular Hydrogen Research Center, Beijing University of Technology, Beijing, 100124, People's Republic of China.

Background: Benign Lymphoepithelial Lesion (BLEL) is a rare disease observed in the adult population. Despite the growing numbers of people suffering from BLEL, the etiology and mechanisms underlying its pathogenesis remain unknown.

Methods: In the present study, we used gene and cytokines expression profiling, western blot and immunohistochemistry to get further insight into the cellular and molecular mechanisms involved in the pathogenesis of BLEL of the lacrimal gland. Read More

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http://dx.doi.org/10.1186/s12964-018-0284-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196440PMC
October 2018
6 Reads

Transferrin receptor 1 is a supplementary receptor that assists transmissible gastroenteritis virus entry into porcine intestinal epithelium.

Cell Commun Signal 2018 Oct 20;16(1):69. Epub 2018 Oct 20.

College of Veterinary Medicine, Nanjing Agricultural University, Wei gang 1, Nanjing, Jiangsu, 210095, People's Republic of China.

Background: Transmissible gastroenteritis virus (TGEV), the etiologic agent of transmissible gastroenteritis, infects swine of all ages causing vomiting and diarrhea, in newborn piglets the mortality rate is near 100%. Intestinal epithelial cells are the primary target cells of TGEV. Transferrin receptor 1 (TfR1), which is highly expressed in piglets with anemia, may play a role in TGEV infection. Read More

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http://dx.doi.org/10.1186/s12964-018-0283-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196004PMC
October 2018
1 Read

TRPV2-induced Ca-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

Cell Commun Signal 2018 Oct 16;16(1):68. Epub 2018 Oct 16.

Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China.

Background: Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation. Nevertheless, the relationships between MBD and highly efficient stimuli of Ca in multiple myeloma (MM) progression, and possible regulatory mechanisms are poorly defined. Here, we reported that the nonselective cation channel transient receptor potential vanilloid 2 (TRPV2) plays a functional role in Ca oscillations and osteoclastogenesis. Read More

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http://dx.doi.org/10.1186/s12964-018-0280-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191893PMC
October 2018
2 Reads

MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells.

Cell Commun Signal 2018 Oct 13;16(1):67. Epub 2018 Oct 13.

Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology (OE 6410), Hannover Medical School, Carl-Neuberg-Str. 1, D -30625, Hannover, Germany.

The tumor microenvironment enables important cellular interactions between cancer cells and recruited adjacent populations including mesenchymal stroma/stem cells (MSC). In vivo cellular interactions of primary human MSC in co-culture with human SK-OV-3 ovarian cancer cells revealed an increased tumor growth as compared to mono-cultures of the ovarian cancer cells. Moreover, the presence of MSC stimulated formation of liver metastases. Read More

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http://dx.doi.org/10.1186/s12964-018-0279-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186086PMC
October 2018
1 Read
3.380 Impact Factor

A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control.

Cell Commun Signal 2018 Oct 11;16(1):66. Epub 2018 Oct 11.

Normandie Univ, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, F-14000, Caen, France.

Background: By allowing intercellular communication between cells, tunneling nanotubes (TNTs) could play critical role in cancer progression. If TNT formation is known to require cytoskeleton remodeling, key mechanism controlling their formation remains poorly understood.

Methods: The cells of human bronchial (HBEC-3, A549) or mesothelial (H2452, H28) lines are transfected with different siRNAs (inactive, anti-RASSF1A, anti-GEFH1 and / or anti-Rab11). Read More

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http://dx.doi.org/10.1186/s12964-018-0276-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180646PMC
October 2018
1 Read

Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels.

Cell Commun Signal 2018 Oct 4;16(1):65. Epub 2018 Oct 4.

Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.

Background: Our previous work revealed that rhomboid domain-containing protein 1 (RHBDD1) participates in the modulation of cell growth and apoptosis in colorectal cancer cells. This study aimed to investigate the function of RHBDD1 in regulating breast cancer progression and its underlying molecular basis.

Methods: Immunohistochemistry was performed to evaluate RHBDD1 expression in 116 breast cancer tissue and 39 adjacent normal tissue and expression of RHBDD1, phospho-Akt (p-Akt) and cyclin-dependent kinase 2 (CDK2) in the same 84 breast cancer specimens. Read More

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http://dx.doi.org/10.1186/s12964-018-0267-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172813PMC
October 2018
3 Reads

Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration.

Cell Commun Signal 2018 Oct 1;16(1):64. Epub 2018 Oct 1.

Department of medical sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Background: Mammalian target of rapamycin (mTOR) is a master regulator of various cellular responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is frequently dysregulated in pancreatic neuroendocrine tumors (PNETs). mTOR inhibitors have been used in attempts to treat these lesions, and prolonged progression free survival has been recorded. Read More

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http://dx.doi.org/10.1186/s12964-018-0278-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167842PMC
October 2018
13 Reads

Cold shock proteins: from cellular mechanisms to pathophysiology and disease.

Cell Commun Signal 2018 Sep 26;16(1):63. Epub 2018 Sep 26.

Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.

Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best characterized members of this family are denoted Y-box binding proteins, such as Y-box binding protein-1 (YB-1). Biological activities range from the regulation of transcription, splicing and translation, to the orchestration of exosomal RNA content. Read More

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http://dx.doi.org/10.1186/s12964-018-0274-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158828PMC
September 2018
7 Reads

TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.

Cell Commun Signal 2018 Sep 21;16(1):62. Epub 2018 Sep 21.

Laboratory of Cell Engineering, Beijing Institute of Biotechnology (BIB), No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, China.

Background: TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unknown.

Results: Here we identified uPA as an interacting partner of TEM8. Read More

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http://dx.doi.org/10.1186/s12964-018-0272-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151050PMC
September 2018
1 Read

IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling.

Cell Commun Signal 2018 Sep 19;16(1):61. Epub 2018 Sep 19.

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Background: Glioblastomas (GBMs), the most common and most lethal of the primary brain tumors, are characterized by marked intra-tumor heterogeneity. Several studies have suggested that within these tumors a restricted population of chemoresistant glioma cells is responsible for recurrence. However, the gene expression patterns underlying chemoresistance are largely unknown. Read More

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http://dx.doi.org/10.1186/s12964-018-0273-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148802PMC
September 2018
1 Read

Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration.

Cell Commun Signal 2018 Sep 18;16(1):60. Epub 2018 Sep 18.

Department of Pediatrics, University of Texas M.D. Anderson Cancer Center, Unit 853, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Background: Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted therapies. Epigenetic perturbations are an established hallmark of human MB and expression of Lysine Specific Demethylase 1 (LSD1) is elevated in MBs compared to normal tissue, suggesting that LSD1 inhibitors may have efficacy against human MB tumors. Read More

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http://dx.doi.org/10.1186/s12964-018-0275-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145331PMC
September 2018
1 Read

MicroRNA let-7b inhibits keratinocyte differentiation by targeting IL-6 mediated ERK signaling in psoriasis.

Cell Commun Signal 2018 Sep 15;16(1):58. Epub 2018 Sep 15.

The Base of "111 Project" for Biomechanics & Tissue Repair Engineering, Key Laboratory of Biorheological Science and Technology, Ministry of Education, college of Bioengineering, Chongqing University, Chongqing, 400044, China.

Background: The extensive involvement of microRNA (miRNA) in the pathophysiology of psoriasis is well documented. However, in order for this information to be useful in therapeutic manipulation of miRNA levels, it is essential that detailed functional mechanisms are elucidated. This study aimed to explore the effects of IL-6 targeting by let-7b and ERK1/2 mediated signaling on keratinocyte differentiation in psoriasis. Read More

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http://dx.doi.org/10.1186/s12964-018-0271-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138911PMC
September 2018

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2.

Cell Commun Signal 2018 Sep 15;16(1):59. Epub 2018 Sep 15.

Unit of Lung Biology, Department of Experimental Medical Sciences, Lund University, BMC C12, 221 84, Lund, Sweden.

Background: Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-going remodeling processes. Read More

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http://dx.doi.org/10.1186/s12964-018-0269-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139170PMC
September 2018
2 Reads

Regulation of the master regulator FOXM1 in cancer.

Cell Commun Signal 2018 Sep 12;16(1):57. Epub 2018 Sep 12.

Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China.

FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for cancer patients. Read More

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http://dx.doi.org/10.1186/s12964-018-0266-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134757PMC
September 2018
18 Reads
3.380 Impact Factor

FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult.

Cell Commun Signal 2018 Sep 10;16(1):56. Epub 2018 Sep 10.

Department of Biological Sciences, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea.

Background: Aberrant cell death induced by ischemic stress is implicated in the pathogenesis of ischemic diseases. Fas-associated factor 1 (FAF1) has been identified as a death-promoting protein. This study demonstrates that FAF1 functions in death signaling triggered by ischemic insult. Read More

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http://dx.doi.org/10.1186/s12964-018-0265-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131785PMC
September 2018

Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells.

Cell Commun Signal 2018 Sep 5;16(1):55. Epub 2018 Sep 5.

Cardiovascular Research Center, School of Medical Sciences, Örebro University Södra Grev Rosengatan 32, 703 62, Örebro, Sweden.

Background: IL-6 classic signaling is linked to anti-inflammatory functions while the trans-signaling is associated with pro-inflammatory responses. Classic signaling is induced via membrane-bound IL-6 receptor (IL-6R) whereas trans-signaling requires prior binding of IL-6 to the soluble IL-6R. In both cases, association with the signal transducing gp130 receptor is compulsory. Read More

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http://dx.doi.org/10.1186/s12964-018-0268-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125866PMC
September 2018

Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.

Cell Commun Signal 2018 Sep 4;16(1):54. Epub 2018 Sep 4.

Department of Surgery, Institute of Biomedical Sciences, Tokushima University of Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.

Background: The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)-Like 2 (Nrf2) not only modulates the angiogenesis but also plays the anti-inflammatory role through inhibiting pro-inflammatory cytokines expression; however, the role of Nrf2 in the cancer cell and macrophages interaction is not clear.

Methods: Hepatocellular carcinoma cells (Hep G2 and Huh 7) and pancreatic cancer cells (SUIT2 and Panc-1) were co-cultured with monocytes cells (THP-1) or peripheral blood monocytes derived macrophages, then the phenotype changes of macrophages and epithelial-mesenchymal transition of cancer cells were detected. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0262-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122794PMC
September 2018
7 Reads

DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer.

Cell Commun Signal 2018 Sep 3;16(1):52. Epub 2018 Sep 3.

Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background: Targeting TopoisomeraseII (TopoII) and generate enzyme mediated DNA damage is an effective strategy for treatment of breast cancer. TopoII is known as a validated target for drug discovery and cancer chemotherapy.

Methods: XWL-1-48, a new orally podophyllotoxin derivative, was designed and synthesized. Read More

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http://dx.doi.org/10.1186/s12964-018-0263-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122736PMC
September 2018
1 Read
3.380 Impact Factor

KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer.

Cell Commun Signal 2018 Sep 3;16(1):53. Epub 2018 Sep 3.

Department of Urology of the First Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, People's Republic of China.

Background: Chemotherapeutic insensitivity remains a big challenge in prostate cancer treatment. Recently, increasing evidence has indicated that KLF4 plays a key role in prostate cancer. However, the potential biological role of KLF4 in Chemotherapeutic insensitivity of prostate cancer is still unknown. Read More

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http://dx.doi.org/10.1186/s12964-018-0270-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122640PMC
September 2018
4 Reads

Chemotherapy induced PRL3 expression promotes cancer growth via plasma membrane remodeling and specific alterations of caveolae-associated signaling.

Cell Commun Signal 2018 Aug 29;16(1):51. Epub 2018 Aug 29.

Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari Krt. 62, Szeged, 6726, Hungary.

Background: The outcome of cancer therapy is greatly defined by the ability of a tumor cell to evade treatment and re-establish its bulk mass after medical interventions. Consequently, there is an urgent need for the characterization of molecules affecting tumor reoccurrence. The phosphatase of regenerating liver 3 (PRL3) protein was recently emerged among the targets that could affect such a phenomenon. Read More

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http://dx.doi.org/10.1186/s12964-018-0264-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116440PMC
August 2018
7 Reads
3.380 Impact Factor

Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90.

Cell Commun Signal 2018 Aug 24;16(1):50. Epub 2018 Aug 24.

Department of Pathology and Pathophysiology, Institute of Pathology and Forensic Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Background: Wilms' tumor 1-associating protein (WTAP) is a nuclear protein, which is ubiquitously expressed in many tissues. Furthermore, in various types of malignancies WTAP is overexpressed and plays a role as an oncogene. The function of WTAP in diffuse large B-cell lymphoma (DLBCL), however, remains unclear. Read More

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http://dx.doi.org/10.1186/s12964-018-0258-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108153PMC
August 2018
3 Reads