630 results match your criteria Cell Communication and Signaling [Journal]


Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect.

Cell Commun Signal 2019 Apr 16;17(1):36. Epub 2019 Apr 16.

Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, 400038, China.

Background: The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and the molecular mechanisms of PC4 in breast cancer development and progression are still unknown.

Methods: We investigated PC4 expression in 114 cases of primary breast cancer and matched normal breast tissue specimens, and studied the impact of PC4 expression as well as the molecular mechanisms of this altered expression on breast cancer growth and metastasis both in vitro and in vivo. Read More

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http://dx.doi.org/10.1186/s12964-019-0348-0DOI Listing

The multifaceted roles of FOXM1 in pulmonary disease.

Cell Commun Signal 2019 Apr 16;17(1):35. Epub 2019 Apr 16.

Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing number of studies have focused on the relationship between abnormal FOXM1 expression and pulmonary diseases, such as lung cancer, chronic obstructive pulmonary disease (COPD), asthma, acute lung injury (ALI), pulmonary fibrosis, and pulmonary arterial hypertension (PAH). These studies indicate that the FOXM1 regulatory network is a major predictor of poor outcomes, especially in lung cancer, and provide novel insight into various pulmonary diseases. Read More

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http://dx.doi.org/10.1186/s12964-019-0347-1DOI Listing

Estrogen regulation of cardiac cAMP-L-type Ca channel pathway modulates sex differences in basal contraction and responses to βAR-mediated stress in left ventricular apical myocytes.

Cell Commun Signal 2019 Apr 15;17(1):34. Epub 2019 Apr 15.

Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Backgrounds/aim: Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Cachannel pathway in adult mice left ventricular (LV) apical myocytes at basal and stress state.

Methods: Isolated LV apical myocytes from male, female (Sham) and ovariectomised mice (OVX) were used to investigate contractility, Ca transients and L-type Ca channel (LTCC) function. Read More

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http://dx.doi.org/10.1186/s12964-019-0346-2DOI Listing

Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown.

Cell Commun Signal 2019 Apr 15;17(1):33. Epub 2019 Apr 15.

Department of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, 5121 Doctors' Office Tower, Nashville, TN, 37232-9075, USA.

Background: Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propagation of the inflammatory reaction. We hypothesized that the loss of eNOS would negatively impact toll-like receptor 3 (TLR3) signaling and worsen vascular function to viral challenge. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0345-3DOI Listing
April 2019
1 Read

Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model.

Cell Commun Signal 2019 Apr 12;17(1):32. Epub 2019 Apr 12.

State Key Laboratory of Respiratory Disease, Center of Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou, 510530, People's Republic of China.

Background: A major challenge in the development of effective cancer immunotherapy is the ability of tumors and their microenvironment to suppress immune cells through immunosuppressive cells such as myeloid -derived suppressor cells and regulatory T cells. We previously demonstrated that Plasmodium infection promotes innate and adaptive immunity against cancer in a murine Lewis lung cancer model but its effects on immunosuppressive cells in the tumor microenvironment are unknown.

Methods: Whole Tumors and tumor-derived sorted cells from tumor-bearing mice treated with or without plasmodium infected red blood cells were harvested 17 days post tumor implantation and analyzed using QPCR, western blotting, flow cytometry, and functional assays. Read More

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http://dx.doi.org/10.1186/s12964-019-0342-6DOI Listing

Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells.

Cell Commun Signal 2019 Apr 11;17(1):31. Epub 2019 Apr 11.

Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, 475004, China.

Background: p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mechanism of PAK1 in esophageal squamous cell carcinoma (ESCC) remain unclear.

Methods: The expression of PAK1 was detected in both ESCC cell lines and clinical samples. Read More

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http://dx.doi.org/10.1186/s12964-019-0343-5DOI Listing

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis.

Cell Commun Signal 2019 03 29;17(1):30. Epub 2019 Mar 29.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation and cell cycle control. However, its role in pancreatic cancer remains unclear. Our study aimed to investigate the roles of PRMT5 in pancreatic cancer prognosis and progression and to explore the underlying molecular mechanism. Read More

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http://dx.doi.org/10.1186/s12964-019-0344-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440122PMC
March 2019
1 Read

Essential roles of EphrinB2 in mammalian heart: from development to diseases.

Cell Commun Signal 2019 03 25;17(1):29. Epub 2019 Mar 25.

Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role during the development of cardiovascular system, postnatal angiogenesis physiologically and pathologically, and cardiac remodeling after injuries as an emerging role. This review highlights the pivotal involvement of EphrinB2 in heart, from developmental cardiogenesis to pathological cardiac remodeling process. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0337-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434800PMC
March 2019
1 Read

DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway.

Cell Commun Signal 2019 03 22;17(1):28. Epub 2019 Mar 22.

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Science, Soochow University, 199 Ren Ai Road, Suzhou, 215123, China.

Background: Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is necessary for p53-mediated apoptosis. However, the signalling pathways regulated by DRAM1 are not fully understood. Read More

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http://dx.doi.org/10.1186/s12964-019-0341-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431019PMC

Targeting pericytes for neurovascular regeneration.

Cell Commun Signal 2019 03 20;17(1):26. Epub 2019 Mar 20.

Neurosciences Research Center (NSRC), Imam Reza Medical Center, Tabriz University of Medical Sciences, Golgasht St., Azadi Ave, Tabriz, 5166614756, Iran.

Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular development and integrity mainly through secreting various factors. Pericytes per se show different restorative properties after blood-brain barrier injury. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0340-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425710PMC
March 2019
6 Reads
3.378 Impact Factor

Recombinant RGD-disintegrin DisBa-01 blocks integrin αβ and impairs VEGF signaling in endothelial cells.

Cell Commun Signal 2019 03 20;17(1):27. Epub 2019 Mar 20.

Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, Rod. Washington Luis, km 235 - SP-310 - São Carlos, São Paulo, CEP 13565-905, Brazil.

Background: Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αβ integrin and VEGF type 2 receptor (VEGFR2) in VEGF-induced angiogenesis. DisBa-01, a recombinant His-tag fusion, RGD-disintegrin from Bothrops alternatus snake venom, binds to αβ integrin with nanomolar affinity blocking cell adhesion to the extracellular matrix. Read More

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http://dx.doi.org/10.1186/s12964-019-0339-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425665PMC
March 2019
2 Reads

Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation.

Cell Commun Signal 2019 03 18;17(1):25. Epub 2019 Mar 18.

Department of Urology, University of California, Irvine, 101 The City Drive South, Rt.81, Bldg.55, Rm.302, Irvine, Orange, CA, 92868, USA.

Background: Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets of FKB in prostate cancer cells remain unknown.

Methods: An in vitro NEDD8 Initiation Conjugation Assay was used to evaluate the neddylation inhibitory activity of FKB. Read More

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http://dx.doi.org/10.1186/s12964-019-0338-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423783PMC

NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer.

Cell Commun Signal 2019 03 18;17(1):24. Epub 2019 Mar 18.

Department of Biochemistry & Molecular Genetics, University of Virginia, P.O. Box 800733, Charlottesville, VA, 22908, USA.

Background: Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered energy utilization, identification of metabolic pathways that link EMT with cancer progression is needed. Work presented here indicates that mesenchymal NSCLC upregulates glutamine-fructose-6-phosphate transaminase 2 (GFPT2). Read More

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http://dx.doi.org/10.1186/s12964-019-0335-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421657PMC

Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis.

Cell Commun Signal 2019 03 12;17(1):23. Epub 2019 Mar 12.

Department of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing University, No.321 Zhongshan Road, 210008, Nanjing, People's Republic of China.

Background: Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to the Warburg effect and tumor proliferation, mechanisms of action remain unclear. Read More

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http://dx.doi.org/10.1186/s12964-019-0332-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417221PMC
March 2019
3 Reads
3.378 Impact Factor

Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1.

Cell Commun Signal 2019 03 5;17(1):22. Epub 2019 Mar 5.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) signaling pathway that some growth factors promoted the migration and proliferation of tumor cells. The aim of this study is to explore the role of GPER-1 in AMF mediated regulatory mechanisms of EC recurrence and progression. Read More

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http://dx.doi.org/10.1186/s12964-019-0336-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402158PMC
March 2019
3 Reads

Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B.

Cell Commun Signal 2019 03 4;17(1):21. Epub 2019 Mar 4.

Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, J1H 4N5, Canada.

Background: Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others, the modulation of cytokine expression patterns. The presence of multiple potential protein-tyrosine phosphatase (PTP) 1B substrates in PAF receptor signaling pathways brought us to investigate its involvement in PAF-induced cytokine expression in monocyte-derived dendritic cells (Mo-DCs) and to study the pathways involved in this modulation.

Methods: We used in-vitro-matured human dendritic cells and the HEK-293 cell line in our studies. Read More

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http://dx.doi.org/10.1186/s12964-019-0334-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399872PMC

A signalling cascade involving receptor-activated phospholipase A, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility.

Cell Commun Signal 2019 03 1;17(1):20. Epub 2019 Mar 1.

Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131, Naples, Italy.

Background: Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses through dephosphorylation of target molecules. Moreover, Shp1 regulates actin dynamics. One Shp1 target is Src, which controls many cellular functions including actin dynamics. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0329-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396489PMC
March 2019
5 Reads

Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS.

Cell Commun Signal 2019 02 28;17(1):19. Epub 2019 Feb 28.

Division of Gastroenterology and Hepatology, Department of Medicine, Stony Brook of University School of Medicine, Stony Brook, New York, 11794, USA.

Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediated pancreatic ductal adenocarcinoma (PDAC). However, the role of HFD in KRAS-mediated metabolic reprogramming has been obscure. Read More

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http://dx.doi.org/10.1186/s12964-019-0333-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396546PMC
February 2019
3.378 Impact Factor

Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway.

Cell Commun Signal 2019 02 27;17(1):18. Epub 2019 Feb 27.

Department of Oral Medicine, Shanxi Medical University School and Hospital of Stomatology, NO. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.

Background: Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apoptosis by regulating microRNA-802 and p53-upregulated modulator of apoptosis (PUMA), but its roles in oral epithelial inflammatory responses in OLP are still unknown. Herein, we identify lipopolysaccharide (LPS) is able to enhance interferon gamma (IFNγ) and interleukin-1 beta (IL-1β) productions in human oral keratinocytes (HOKs) dependent on hypoxia-inducible factor-1α (HIF-1α). Read More

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http://dx.doi.org/10.1186/s12964-019-0331-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391768PMC
February 2019

Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target.

Cell Commun Signal 2019 02 26;17(1):17. Epub 2019 Feb 26.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Background: Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used clinically under FDA approval for application in cancer therapeutic remedies. However, the level of CDK4 and the treatment possibility in chondrosarcoma require further exploration. Read More

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http://dx.doi.org/10.1186/s12964-019-0327-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390580PMC
February 2019
2 Reads

The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles.

Cell Commun Signal 2019 02 21;17(1):16. Epub 2019 Feb 21.

Department of Cell Biology, Army Medical University, Gaotanyan street No. 30, Shapingba, Chongqing, 400038, China.

Background: The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein that controls this process has not been revealed.

Methods: The expression of BMP6 was determined via in situ hybridization and immunofluorescence. Read More

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http://dx.doi.org/10.1186/s12964-019-0330-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385416PMC
February 2019
1 Read

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells.

Cell Commun Signal 2019 02 20;17(1):14. Epub 2019 Feb 20.

Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park Bâtiment G, 1015, Lausanne, Switzerland.

Background: Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is associated with a pronounced increase in mitochondrial respiration. Read More

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http://dx.doi.org/10.1186/s12964-019-0326-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381748PMC
February 2019

Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer.

Cell Commun Signal 2019 02 20;17(1):15. Epub 2019 Feb 20.

Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.

Background: ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by membrane physical properties. The present study aims to investigate the influence of membrane cholesterol contents on ErbB2 status and cellular responses to its tyrosine kinase inhibitors. Read More

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http://dx.doi.org/10.1186/s12964-019-0328-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383291PMC
February 2019
1 Read
3.378 Impact Factor

Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells.

Cell Commun Signal 2019 02 19;17(1):13. Epub 2019 Feb 19.

Department of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 411A, Oklahoma City, OK, 73104, USA.

Background: Exosomes are small membrane-bound vesicles that contribute to tumor progression and metastasis by mediating cell-to-cell communication and modifying the tumor microenvironment at both local and distant sites. However, little is known about the predominant factors in exosomes that contribute to breast cancer (BC) progression. MTA1 is a transcriptional co-regulator that can act as both a co-activator and co-repressor to regulate pathways that contribute to cancer development. Read More

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http://dx.doi.org/10.1186/s12964-019-0325-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379974PMC
February 2019

Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation.

Cell Commun Signal 2019 02 13;17(1):12. Epub 2019 Feb 13.

Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.

Background: The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroid disease. While high-dose therapy has been beneficial to several cancer patients, many studies have indicated this clinical benefit was limited to patients having BRAF mutation. BRAF-targeted paired box gene-8 (PAX8), a thyroid-specific transcription factor, generally dysregulated in BRAF-mutated thyroid cancer. Read More

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http://dx.doi.org/10.1186/s12964-019-0322-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373124PMC
February 2019
1 Read

Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.

Cell Commun Signal 2019 02 11;17(1):11. Epub 2019 Feb 11.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Background: Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC contraction was affected by the natural compound oroxylin A, and elucidated the underlying mechanism.

Methods: Cell contraction and glycolysis were examined in cultured human HSCs and mouse liver fibrosis model upon oroxylin A intervention using diversified cellular and molecular assays, as well as genetic approaches. Read More

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http://dx.doi.org/10.1186/s12964-019-0324-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371416PMC
February 2019
7 Reads
3.378 Impact Factor

Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis.

Cell Commun Signal 2019 01 31;17(1):10. Epub 2019 Jan 31.

Department of Biosciences, Division of Microbiology, University of Salzburg, Paris-Lodron University of Salzburg, Billroth Str. 11, A-5020, Salzburg, Austria.

Background: Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate the oncoprotein cytotoxin-associated gene A (CagA). The role of c-Abl in CagA-dependent pathways is well established; however, the knowledge of CagA-independent c-Abl processes is scarce. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0323-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357398PMC
January 2019
10 Reads

Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway.

Cell Commun Signal 2019 01 25;17(1). Epub 2019 Jan 25.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.

Background: Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghrelin on glucose homeostasis and insulin signaling in the liver. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0321-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347823PMC
January 2019
6 Reads

Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway.

Cell Commun Signal 2019 01 25;17(1). Epub 2019 Jan 25.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 West Yanjiang Road, Guangzhou, 510120, Guangdong, China.

Background: To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.

Methods: Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeline (ChAMP) analysis was employed for differential methylated points (DMPs) and the differential methylation regions (DMRs) screening. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0316-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347846PMC
January 2019
12 Reads

The protein kinase Cmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in budding yeast.

Cell Commun Signal 2019 01 21;17(1). Epub 2019 Jan 21.

Laboratory for Yeast Molecular and Cell Biology, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, Shandong, China.

Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the calcium signalling pathway, the protein kinase gene CMK2, the sphingolipid homeostasis-related gene ORM2 and the gene SIF2 encoding the WD40 repeat-containing subunit of Set3C histone deacetylase complex are involved in the calcium sensitivity of yeast cells to extracellular calcium. Cmk2 and the transcription factor Crz1 have opposite functions in the response of yeast cells to calcium stress. Read More

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http://dx.doi.org/10.1186/s12964-019-0320-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341702PMC
January 2019

Extracellular vesicles in bone: "dogrobbers" in the "eternal battle field".

Cell Commun Signal 2019 01 18;17(1). Epub 2019 Jan 18.

Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Throughout human life, bone is constantly in a delicate dynamic equilibrium of synthesis and resorption, hosting finely-tuned bone mineral metabolic processes for bone homeostasis by collaboration or symphony among several cell types including osteoclasts (OCs), osteoblasts (OBs), osteocytes (OYs), vascular endothelial cells (ECs) and their precursors. Beyond these connections, a substantial level of communication seems to occur between bone and other tissues, and together, they form an organic unit linked to human health and disease. However, the current hypothesis, which includes growth factors, hormones and specific protein secretion, incompletely explains the close connections among bone cells or between bone and other tissues. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-019-0319-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339294PMC
January 2019
10 Reads
3.378 Impact Factor

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.

Cell Commun Signal 2019 01 16;17(1). Epub 2019 Jan 16.

Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

Background: Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated K1. Read More

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http://dx.doi.org/10.1186/s12964-018-0317-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335768PMC
January 2019
4 Reads
3.378 Impact Factor

Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.

Cell Commun Signal 2019 01 14;17(1). Epub 2019 Jan 14.

Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Collaborative Innovation Center of Cancer Medicine, Shanghai Medical College, Fudan University, 270 Dong'an Road, Shanghai, 200032, China.

Background: As the first member of the metastasis-associated protein (MTA) family, MTA1 and another MTA family member, MTA2, have both been reported to promote breast cancer progression and metastasis. However, the difference and relationship between MTA1 and MTA2 have not been fully elucidated.

Methods: Transwell assays were used to assess the roles of MTA1 and MTA2 in the metastasis of ZR-75-30 luminal B breast cancer cells in vitro. Read More

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http://dx.doi.org/10.1186/s12964-019-0318-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332694PMC
January 2019
4 Reads

Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma.

Cell Commun Signal 2019 01 11;17(1). Epub 2019 Jan 11.

The Base of "111 Project" for Biomechanics and Tissue Repair Engineering, Bioengineering college and Life Science College, Chongqing University, Chongqing, 400044, China.

Background: Despite therapeutic advancements (e.g. B-RAF inhibitors) targeting cutaneous melanoma, many cellular processes, including inducible heme oxygenase 1 (HO-1), counteract treatments for malignancies. Read More

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http://dx.doi.org/10.1186/s12964-018-0313-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329143PMC
January 2019
7 Reads

Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway.

Cell Commun Signal 2019 01 10;17(1). Epub 2019 Jan 10.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Xi'an Road 5333#, Changchun, Jilin, 130062, People's Republic of China.

Background: Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, is essential for alleviating APAP-induced hepatotoxicity. Corilagin (Cori) is a natural polyphenol compound that possesses effective antioxidant activity; however, the protective effect of Cori on APAP-induced hepatotoxicity is still unknown. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0314-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327405PMC
January 2019
10 Reads

Exosomes in hepatocellular carcinoma: a new horizon.

Cell Commun Signal 2019 01 7;17(1). Epub 2019 Jan 7.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.

Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cell communication has been extensively studied, showed that exosomes can deliver their functional RNAs and proteins to recipient cells, impacting transcription and translation of recipient cells. Emerging evidence suggests that hepatocellular carcinoma (HCC) cell-derived exosomes can construct a fertile environment to support HCC cells proliferation, grow, invasion and metastasis, development of drug resistance. Read More

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http://dx.doi.org/10.1186/s12964-018-0315-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323788PMC
January 2019
8 Reads

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation.

Cell Commun Signal 2018 12 19;16(1):101. Epub 2018 Dec 19.

Instituto de Biología Molecular y Celular del Cáncer (IMBCC), Universidad de Salamanca-CSIC, Salamanca, Spain.

Background: Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in platelet activation and regulates several differentiation processes. Read More

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http://dx.doi.org/10.1186/s12964-018-0311-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299959PMC
December 2018
1 Read

Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression.

Cell Commun Signal 2018 12 18;16(1):100. Epub 2018 Dec 18.

Jiangsu Key laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.

Background: Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adipocyte-breast cancer interactions have been considered important for the promotion of breast cancer metastasis. Read More

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http://dx.doi.org/10.1186/s12964-018-0309-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299564PMC
December 2018
8 Reads

Blockade of ARHGAP11A reverses malignant progress via inactivating Rac1B in hepatocellular carcinoma.

Cell Commun Signal 2018 12 13;16(1):99. Epub 2018 Dec 13.

Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background: The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of currently known targets has not yet led to successful clinical outcome. More understanding about the regulatory mechanisms in HCC is necessary for developing new effective therapeutic strategies for HCC patients. Read More

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http://dx.doi.org/10.1186/s12964-018-0312-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293628PMC
December 2018
14 Reads

Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.

Cell Commun Signal 2018 12 12;16(1):98. Epub 2018 Dec 12.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.

Background: Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.

Methods: Using single receptor-deficient platelets from TAM knockout mice in the C57BL/6 J strain, we performed a knockout study using single TAM-deficient mice. Read More

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http://dx.doi.org/10.1186/s12964-018-0308-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291976PMC
December 2018
8 Reads

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle.

Cell Commun Signal 2018 12 7;16(1):97. Epub 2018 Dec 7.

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by the loss of muscle strength and mass, is one of the pathological conditions regulated by TGF-β1, but the underlying mechanism involved in the atrophic effects of TGF-β1 is not fully understood.

Methods: Mice sciatic nerve transection model was created and gastrocnemius were analysed by western blot, immunofluorescence staining and fibre diameter quantification after 2 weeks. Read More

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http://dx.doi.org/10.1186/s12964-018-0310-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286536PMC
December 2018
8 Reads

bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling.

Cell Commun Signal 2018 12 5;16(1):96. Epub 2018 Dec 5.

Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich Heine University, Düsseldorf, Germany.

Background: Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. Read More

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http://dx.doi.org/10.1186/s12964-018-0307-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282345PMC
December 2018
3 Reads

Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.

Cell Commun Signal 2018 12 5;16(1):95. Epub 2018 Dec 5.

Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, 150040, People's Republic of China.

Background: The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. Jumeau (Jumu) is a member of the winged-helix/forkhead (FKH) transcription factor family and is required for Drosophila development. Adult jumu mutant flies show defective hemocyte phagocytosis and a weaker defense capability against pathogen infection. Read More

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http://dx.doi.org/10.1186/s12964-018-0305-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280549PMC
December 2018
3 Reads

Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice.

Cell Commun Signal 2018 12 3;16(1):93. Epub 2018 Dec 3.

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFRα in non-cancerous hepatocytes and liver fibrosis is unclear. Read More

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http://dx.doi.org/10.1186/s12964-018-0306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276164PMC
December 2018
2 Reads

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.

Cell Commun Signal 2018 12 4;16(1):94. Epub 2018 Dec 4.

Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Background: TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-driven cell-invasive phenotype. We found that AMAP1 levels are under the control of p53 (TP53 gene product) in epithelial cells but not in fibroblasts, and here addressed that molecular basis of the epithelial-specific function of p53 in suppressing invasiveness via targeting AMAP1. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0302-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278066PMC
December 2018
14 Reads

Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes.

Cell Commun Signal 2018 11 29;16(1):91. Epub 2018 Nov 29.

Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, Heilongjiang Province, China.

Background: The link between cardiac diseases and cognitive deterioration has been accepted from the concept of "cardiogenic dementia", which was proposed in the late 1970s. However, the molecular mechanism is unclarified.

Methods: The two animal models used in this study were cardiac-specific overexpression of microRNA-1-2 transgenic (Tg) mice and a myocardial infarction mouse model generated by left coronary artery ligation (LCA). Read More

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http://dx.doi.org/10.1186/s12964-018-0303-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267908PMC
November 2018
4 Reads

Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.

Cell Commun Signal 2018 11 29;16(1):92. Epub 2018 Nov 29.

Department of General Surgery, the Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, China.

Background: Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (TNBC) to chemotherapy remains a major clinical problem. Our previous study demonstrated that the expression levels of PTN and its receptor PTPRZ1 were upregulated in recurrent TNBC tissue after chemotherapy, and this increase was closely related to poor prognosis in those patients. Read More

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http://dx.doi.org/10.1186/s12964-018-0304-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267809PMC
November 2018
1 Read

Correction to: Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

Cell Commun Signal 2018 11 26;16(1):90. Epub 2018 Nov 26.

Department of Biotechnology and Health Science, Molecular Biotechnology Center, Università di Torino, Via Nizza, 52, Torino, Italy.

Following publication of the original article [1], the authors reported an error in the name of the 11th author. The author's name was incorrectly published as "Vincenzo Calautti", instead of "Enzo Calautti". Read More

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http://dx.doi.org/10.1186/s12964-018-0296-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258440PMC
November 2018
4 Reads

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis.

Cell Commun Signal 2018 11 23;16(1):89. Epub 2018 Nov 23.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Hankou Road 22, Nanjing, 210093, China.

Background: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident mesenchymal stem cells (LR-MSCs) have been identified as an important contributor to myofibroblast activation in pulmonary fibrosis. Macrophages are also believed to play a critical role in pulmonary fibrosis. Read More

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https://biosignaling.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12964-018-0300-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260991PMC
November 2018
20 Reads
3.380 Impact Factor

SOX2 as a novel contributor of oxidative metabolism in melanoma cells.

Cell Commun Signal 2018 11 22;16(1):87. Epub 2018 Nov 22.

Department of Clinical and Experimental Biomedical Sciences "Mario Serio", Section of Experimental Pathology and Oncology, University of Florence, Viale G.B. Morgagni, 50, 50134, Florence, Italy.

Background: Deregulated metabolism is a hallmark of cancer and recent evidence underlines that targeting tumor energetics may improve therapy response and patient outcome. Despite the general attitude of cancer cells to exploit the glycolytic pathway even in the presence of oxygen (aerobic glycolysis or "Warburg effect"), tumor metabolism is extremely plastic, and such ability to switch from glycolysis to oxidative phosphorylation (OxPhos) allows cancer cells to survive under hostile microenvironments. Recently, OxPhos has been related with malignant progression, chemo-resistance and metastasis. Read More

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http://dx.doi.org/10.1186/s12964-018-0297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249961PMC
November 2018
16 Reads