878 results match your criteria Cell Communication and Signaling [Journal]


Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS.

Cell Commun Signal 2020 Jul 11;18(1):111. Epub 2020 Jul 11.

Queens College and Graduate Center, City University of New York, 65-30 Kissena Blvd, NSB E143, Flushing, NY, 11367, USA.

Background: Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation. We evaluated the mechanism for this difference in the controlled situation of their response to ethanol.

Methods: We evaluated the expression of mRNA for alcohol dehydrogenase (ADH), aldehyde dehyrogenases (ALDH), and a cytochrome P450 isoenzyme (Cyp2e1) in male and female mice, comparing the expressions to toxicity under several experimental conditions evaluating redox and other states. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00616-8DOI Listing

The role of Wnt/β-catenin-lin28a/let-7 axis in embryo implantation competency and epithelial-mesenchymal transition (EMT).

Cell Commun Signal 2020 Jul 11;18(1):108. Epub 2020 Jul 11.

Department of Obstetrics and Gynaecology, Laboratory Block, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China.

Background: The pre-implantation embryo in a competent status and post-implantation fully differentiation of the inner cell mass (ICM) and trophectoderm (TE) are prerequisites of successful implantation. Type I embryonic epithelial-mesenchymal transition (EMT) involves in these processes. A high level of the mir-let-7 family was found in the dormant mouse embryo of implantation failure in our previous study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00562-5DOI Listing

lncRNA HOTAIR overexpression induced downregulation of c-Met signaling promotes hybrid epithelial/mesenchymal phenotype in hepatocellular carcinoma cells.

Cell Commun Signal 2020 Jul 11;18(1):110. Epub 2020 Jul 11.

Izmir Biomedicine and Genome Center (IBG), Balcova, 35340, Izmir, Turkey.

Background: Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are both reversible processes, and regulation of phenotypical transition is very important for progression of several cancers including hepatocellular carcinoma (HCC). Recently, it is defined that cancer cells can attain a hybrid epithelial/mesenchymal (hybrid E/M) phenotype. Cells with hybrid E/M phenotype comprise mixed epithelial and mesenchymal properties, they can be more resistant to therapeutics and also more capable of initiating metastatic lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00602-0DOI Listing

Prion peptide-mediated calcium level alteration governs neuronal cell damage through AMPK-autophagy flux.

Cell Commun Signal 2020 Jul 11;18(1):109. Epub 2020 Jul 11.

Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Gobong ro, Iksan, Jeonbuk, 54596, South Korea.

Background: The distinctive molecular structure of the prion protein, PrPsc, is established only in mammals with infectious prion diseases. Prion protein characterizes either the transmissible pathogen itself or a primary constituent of the disease. Our report suggested that prion protein-mediated neuronal cell death is triggered by the autophagy flux. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00590-1DOI Listing

MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function.

Cell Commun Signal 2020 Jul 9;18(1):107. Epub 2020 Jul 9.

Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, Hubei, 430081, PR China.

Background: Foxp3CD4 regulatory T cells (Treg) constitutes a key event in autoimmune diseases. STAT5b is the critical link between the IL-2/15 and FOXP3, the master regulator of Treg cells.

Methods: The CD3T cell and Foxp3CD4 regulatory T cells were overexpressioned or knockdown MKL-1 and STAT5a and tested for Treg cell development and function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00574-1DOI Listing

Phospho-Tyr705 of STAT3 is a therapeutic target for sepsis through regulating inflammation and coagulation.

Cell Commun Signal 2020 Jul 8;18(1):104. Epub 2020 Jul 8.

Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang road, Wenzhou, Zhejiang, 325000, P.R. China.

Background: Sepsis is an infection-induced aggressive and life-threatening organ dysfunction with high morbidity and mortality worldwide. Infection-associated inflammation and coagulation promote the progression of adverse outcomes in sepsis. Here, we report that phospho-Tyr705 of STAT3 (pY-STAT3), not total STAT3, contributes to systemic inflammation and coagulopathy in sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00603-zDOI Listing

Renal cancer-derived exosomes induce tumor immune tolerance by MDSCs-mediated antigen-specific immunosuppression.

Cell Commun Signal 2020 Jul 8;18(1):106. Epub 2020 Jul 8.

Department of Urology, The First Affiliated Hospital of Chongqing Medical University, No. 1, medical college road, Yuzhong district, Chongqing, 408000, China.

Backgound: Although Myeloid-derived suppressor cells (MDSCs) have a prominent ability to suppress the immune responses of T lymphocytes and propel tumor immune escape, a lack of profound systemic immunesuppression in tumor-bearing mice and tumor patients. The underlying mechanism of these remains unclear.

Methods: For this purpose, renal cancer-derived exosomes (RDEs) were first labeled with PKH67 and been observed the internalization by MDSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00611-zDOI Listing

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes.

Cell Commun Signal 2020 Jul 8;18(1):105. Epub 2020 Jul 8.

Division of Nephrology, Department of Medicine, The Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1003, New York, NY, 10029, USA.

Background: In the setting of diabetes mellitus, mitochondrial dysfunction and oxidative stress are important pathogenic mechanisms causing end organ damage, including diabetic kidney disease (DKD), but mechanistic understanding at a cellular level remains obscure. In mouse models of DKD, glomerular endothelial cell (GEC) dysfunction precedes albuminuria and contributes to neighboring podocyte dysfunction, implicating GECs in breakdown of the glomerular filtration barrier. In the following studies we wished to explore the cellular mechanisms by which GECs become dysfunctional in the diabetic milieu, and the impact to neighboring podocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00605-xDOI Listing

Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype.

Cell Commun Signal 2020 Jul 7;18(1):103. Epub 2020 Jul 7.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Background: We previously demonstrated that ovarian high grade serous carcinomas (OHGSeCa) and ovarian clear cell carcinomas (OCCCa) with an HNF-1β+/p53+/ARID1A+ immunophenotype were associated with the worst unfavorable prognosis. To clarify the molecular mechanisms underlying this finding, we focused on alterations in the p53 signaling pathway in these tumors.

Methods: Changes in cell phenotype and function following knockdown of wild-type p53 (p53-KD) were assessed using OCCCa cells expressing endogenous HNF-1β and ARID1A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00580-3DOI Listing

Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.

Cell Commun Signal 2020 Jun 25;18(1):102. Epub 2020 Jun 25.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC). Characterization of Wnt effector pathways is key for our understanding of these processes and for developing therapeutic strategies that aim to preserve tissue homeostasis. O-glycosylated cell surface proteins, such as α-dystroglycan (α-DG), mediate cellular adhesion to extracellular matrix components. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00561-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315491PMC

High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.

Cell Commun Signal 2020 Jun 24;18(1):101. Epub 2020 Jun 24.

Department of Molecular Biology, Hokkaido University Faculty of Medicine, N15W7 Kitaku, Sapporo, 060-8638, Japan.

Background: Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in which hyperactivation of focal adhesion kinase (FAK) in tumor cells was shown to be crucial. Double mutations of KRAS/ TP53 are characteristic to PDAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00608-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313132PMC

Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma.

Cell Commun Signal 2020 Jun 23;18(1):97. Epub 2020 Jun 23.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui, 323000, PR China.

Background: Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predicts a poor prognosis in cancer patients.

Methods: Molecular profiles from The Cancer Genome Atlas (TCGA) cohort were used to analyze the prognostic value of glycolysis gene signature in human cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00539-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310503PMC

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation.

Cell Commun Signal 2020 Jun 23;18(1):98. Epub 2020 Jun 23.

Department of Respiratory and Critical Care Medicine, Yangpu Hospital, Tongji Universtiy School Of Medicine, Shanghai, China.

Background And Purpose: Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal. It is important to exploit new potential of molecularly targeted therapies. High-frequency somatic mutations in KEAP1/NRF2 (27. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00568-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310414PMC
June 2020
3.378 Impact Factor

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells.

Cell Commun Signal 2020 Jun 23;18(1):99. Epub 2020 Jun 23.

Department of Biosciences, Bioanalytical Research Laboratories and Molecular Cancer Research and Tumor Immunology, Cancer Cluster Salzburg, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.

Background: Aberrant hedgehog (HH) signaling is implicated in the development of various cancer entities such as medulloblastoma. Activation of GLI transcription factors was revealed as the driving force upon pathway activation. Increased phosphorylation of essential effectors such as Smoothened (SMO) and GLI proteins by kinases including Protein Kinase A, Casein Kinase 1, and Glycogen Synthase Kinase 3 β controls effector activity, stability and processing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00591-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310537PMC

FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1.

Cell Commun Signal 2020 Jun 23;18(1):100. Epub 2020 Jun 23.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China.

Background: Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, little is known about the mechanism of HSP90AA1 regulation.

Methods: Transcriptome RNA-sequencing data of hepatocellular carcinoma (HCC) samples were used to detect the mRNA expression of FBXL6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00604-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310287PMC

Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells.

Cell Commun Signal 2020 Jun 17;18(1):95. Epub 2020 Jun 17.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL, 32827, USA.

Background: While inflammation is associated with pancreatic cancer, the underlying mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote or inhibit tumor growth, although the specific role in pancreatic cancer has yet to be determined. Eosinophil-supporting cytokine interleukin-5 and receptor are likely to have a role, but the significance in the pancreatic cancer microenvironment is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00594-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302008PMC

Gastrin-releasing peptide induces fibrotic response in MRC5s and proliferation in A549s.

Cell Commun Signal 2020 Jun 18;18(1):96. Epub 2020 Jun 18.

Department of Pulmonary Diseases, Cerrahpasa School of Medicine, Istanbul University Cerrahpasa, Fatih, Istanbul, Turkey.

Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, whose build-up scar tissue is induced by several molecules. Gastrin-releasing peptide (GRP) is released from pulmonary neuroendocrine cells, alveolar macrophages, and some nerve endings in the lung. A possible role of GRP in IPF is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00585-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301567PMC

β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes.

Cell Commun Signal 2020 Jun 16;18(1):93. Epub 2020 Jun 16.

Rush University Medical Center, Department of Microbial Pathogens and Immunity, Rush University Medical College, 1735 W. Harrison Street, 614 Cohn, Chicago, IL, 60612, USA.

Background: The Wnt/β-catenin signaling pathway is a prolific regulator of cell-to-cell communication and gene expression. Canonical Wnt/β-catenin signaling involves partnering of β-catenin with members of the TCF/LEF family of transcription factors (TCF1, TCF3, TCF4, LEF1) to regulate gene expression. IL-6 is a key cytokine involved in inflammation and is particularly a hallmark of inflammation in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00565-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296971PMC

The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effect.

Cell Commun Signal 2020 Jun 16;18(1):94. Epub 2020 Jun 16.

INSERM UMR-S-MD 1197, Hôpital Paul Brousse, Villejuif, France.

Background: Endothelial progenitor cells (EPCs) are non-differentiated endothelial cells (ECs) present in blood circulation that are involved in neo-vascularization and correction of damaged endothelial sites. Since EPCs from patients with vascular disorders are impaired and inefficient, allogenic sources from adult or cord blood are considered as good alternatives. However, due to the reaction of immune system against allogenic cells which usually lead to their elimination, we focused on the exact role of EPCs on immune cells, particularly, T cells which are the most important cells applied in immune rejection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00564-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298859PMC
June 2020
3.378 Impact Factor

Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells.

Cell Commun Signal 2020 Jun 11;18(1):91. Epub 2020 Jun 11.

Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Background: RNF43 and its homolog ZNRF3 are transmembrane E3 ubiquitin ligases frequently mutated in many human cancer types. Their main role relays on the inhibition of canonical Wnt signaling by the negative regulation of frizzled receptors and LRP5/6 co-receptors levels at the plasma membrane. Intracellular RING domains of RNF43/ZNRF3 mediate the key enzymatic activity of these proteins, but the function of the extracellular Protease Associated (PA) fold in the inhibition of Wnt/β-catenin pathway is controversial up-to date, apart from the interaction with secreted antagonists R-spondin family proteins shown by the crystallographic studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00559-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291719PMC

PINOT: an intuitive resource for integrating protein-protein interactions.

Cell Commun Signal 2020 Jun 11;18(1):92. Epub 2020 Jun 11.

School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AP, UK.

Background: The past decade has seen the rise of omics data for the understanding of biological systems in health and disease. This wealth of information includes protein-protein interaction (PPI) data derived from both low- and high-throughput assays, which are curated into multiple databases that capture the extent of available information from the peer-reviewed literature. Although these curation efforts are extremely useful, reliably downloading and integrating PPI data from the variety of available repositories is challenging and time consuming. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00554-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291677PMC
June 2020
3.378 Impact Factor

Intestinal microbiota: a new force in cancer immunotherapy.

Cell Commun Signal 2020 Jun 10;18(1):90. Epub 2020 Jun 10.

Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, 225001, P. R. China.

Cancer displays high levels of heterogeneity and mutation potential, and curing cancer remains a challenge that clinicians and researchers are eager to overcome. In recent years, the emergence of cancer immunotherapy has brought hope to many patients with cancer. Cancer immunotherapy reactivates the immune function of immune cells by blocking immune checkpoints, thereby restoring the anti-tumor activity of immune cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00599-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288675PMC

TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus.

Cell Commun Signal 2020 Jun 9;18(1):87. Epub 2020 Jun 9.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, MA, 02114, USA.

Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found in many pathophysiological heart conditions. A range of molecular components and cellular pathways, have been implicated in its pathogenesis. In this review, we focus on the TGF-β and WNT signaling pathways, and their mutual interaction, which have emerged as important factors involved in cardiac pathophysiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00555-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281690PMC

Remodelling of the bone marrow microenvironment by stromal hyaluronan modulates the malignancy of breast cancer cells.

Cell Commun Signal 2020 Jun 9;18(1):89. Epub 2020 Jun 9.

Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, People's Republic of China.

Background: Hyaluronan (HA) is an abundant component of the bone marrow (BM) extracellular matrix. Here, we investigated the abnormal deposition of HA in the BM microenvironment and its remodelling in mediating the malignancy of breast cancer cells (BCCs).

Methods: BCCs were transplanted into nude mice by intracardiac injection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00592-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285718PMC

Autophagy in cancers including brain tumors: role of MicroRNAs.

Cell Commun Signal 2020 Jun 9;18(1):88. Epub 2020 Jun 9.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, MA, 02114, USA.

Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00587-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285723PMC

Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells.

Cell Commun Signal 2020 Jun 9;18(1):86. Epub 2020 Jun 9.

Department of Life Science, Kyonggi University, Suwon, 16227, South Korea.

Background: Protease-activated receptor 4 (PAR4) is a seven transmembrane G-protein coupled receptor (GPCR) activated by endogenous proteases, such as thrombin. PAR4 is involved in various pathophysiologies including cancer, inflammation, pain, and thrombosis. Although regulators of G-protein signaling (RGS) are known to modulate GPCR/Gα-mediated pathways, their specific effects on PAR4 are not fully understood at present. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00552-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285472PMC

MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma.

Cell Commun Signal 2020 Jun 5;18(1):85. Epub 2020 Jun 5.

Institute of Anatomy and Cell Biology, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse 52, 06108, Halle, Saale, Germany.

Background: Metastasis-associated in colon cancer 1 (MACC1) is an established marker for metastasis and tumor cell migration in a multitude of tumor entities, including glioblastoma (GBM). Nevertheless, the mechanism underlying the increased migratory capacity in GBM is not comprehensively explored.

Methods: We performed live cell and atomic force microscopy measurements to assess cell migration and mechanical properties of MACC1 overexpressing GBM cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00566-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275321PMC

Estrogen-ERα signaling and DNA hypomethylation co-regulate expression of stem cell protein PIWIL1 in ERα-positive endometrial cancer cells.

Cell Commun Signal 2020 Jun 5;18(1):84. Epub 2020 Jun 5.

Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Tong Ji University School of Medicine, No. 536, Changle Road, Shanghai, 200080, China.

Background: We previously identified PIWIL1 as an oncogene involved in endometrial carcinogenesis. However, the mechanism of Piwil1 mediated regulation of tumorigenesis remains poorly understood.

Methods: The expression levels of target genes in endometrial cancer cells were detected by quantitative reverse transcription-PCR (RT-qPCR) and western blotting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00563-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275358PMC

Regulators of glucose uptake in thyroid cancer cell lines.

Cell Commun Signal 2020 Jun 3;18(1):83. Epub 2020 Jun 3.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Thyroid cancer is the most common sort of endocrine-related cancer with more prevalent in women and elderly individuals which has quickly widespread expansion in worldwide over the recent decades. Common features of malignant thyroid cells are to have accelerated metabolism and increased glucose uptake to optimize their energy supply which provides a fundamental advantage for growth. In tumor cells the retaining of required energy charge for cell survival is imperative, indeed glucose transporters are enable of promoting of this task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00586-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268348PMC

CCL2/CCR2 signaling in cancer pathogenesis.

Cell Commun Signal 2020 May 29;18(1):82. Epub 2020 May 29.

Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, 90059, USA.

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer. The progression and metastasis of prostate cancer involve a complex network of chemokines that regulate the recruitment and trafficking of immune cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00589-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257158PMC
May 2020
3.378 Impact Factor

Exogenous fibroblast growth factor 1 ameliorates diabetes-induced cognitive decline via coordinately regulating PI3K/AKT signaling and PERK signaling.

Cell Commun Signal 2020 May 27;18(1):81. Epub 2020 May 27.

Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.

Background: Diabetes induces central nervous system damage, leading to cognitive decline. Fibroblast growth factor 1 (FGF1) has dual function of neuroprotection and normalizing hyperglycemia. To date, the precise mechanisms and potential treating strategies of FGF1 for diabetes-induced cognitive decline (DICD) hasn't been fully elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00588-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251863PMC

CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.

Cell Commun Signal 2020 May 27;18(1):80. Epub 2020 May 27.

Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, Room R2034 - 351 Taché Avenue, Winnipeg, MB, R2H 2A6, Canada.

Background: Circulatory iron is a hazardous biometal. Therefore, iron is transported in a redox-safe state by a serum glycoprotein - transferrin (TF). Different organs acquire iron from the systemic circulation through a tightly regulated mechanism at the blood-tissue interface which involves receptor-mediated internalization of TF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00575-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251913PMC

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease.

Cell Commun Signal 2020 May 25;18(1):79. Epub 2020 May 25.

Joseph Banks Laboratories, School of Life Sciences, University of Lincoln, Green Lane, Lincoln, UK.

Background: Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosphate (ATP) release in purinergic-mediated disassembly of adherens and tight junction complexes in early tubular injury.

Methods: Human primary proximal tubule epithelial cells (hPTECs) and clonal tubular epithelial cells (HK2) were treated with Transforming Growth Factor Beta1 (TGF-β1) ± apyrase, or ATPγS for 48 h. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00558-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249671PMC

Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival.

Cell Commun Signal 2020 May 25;18(1):78. Epub 2020 May 25.

Department of Microbiology, Immunology, and Cell Biology; West Virginia University, 1 Medical Center Drive, Morgantown, 26506, WV, US.

Background: Oncogenesis rewires signaling networks to confer a fitness advantage to malignant cells. For instance, the B16F0 melanoma cell model creates a cytokine sink for Interleukin-12 (IL-12) to deprive neighboring cells of this important anti-tumor immune signal. While a cytokine sink provides an indirect fitness advantage, does IL-12 provide an intrinsic advantage to B16F0 cells?

Methods: Acute in vitro viability assays were used to compare the cytotoxic effect of imatinib on a melanoma cell line of spontaneous origin (B16F0) with a normal melanocyte cell line (Melan-A) in the presence of IL-12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00547-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249691PMC

Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling.

Cell Commun Signal 2020 May 24;18(1):77. Epub 2020 May 24.

System Microscopy Centre, School of Biology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Background: Ability to adapt to temperature changes trough the Heat Shock Response (HSR) pathways is one of the most fundamental and clinically relevant cellular response systems. Heat Shock (HS) affects the signalling and gene expression responses of the Nuclear Factor κB (NF-κB) transcription factor, a critical regulator of proliferation and inflammation, however, our quantitative understanding of how cells sense and adapt to temperature changes is limited.

Methods: We used live-cell time-lapse microscopy and mathematical modelling to understand the signalling of the NF-κB system in the human MCF7 breast adenocarcinoma cells in response to pro-inflammatory Interleukin 1β (IL1β) and Tumour Necrosis Factor α (TNFα) cytokines, following exposure to a 37-43 °C range of physiological and clinical temperatures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00583-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245923PMC

Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch.

Cell Commun Signal 2020 May 19;18(1):76. Epub 2020 May 19.

Department of Clinical and Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161, Rome, Italy.

Background: The epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) controls the entire program of keratinocyte differentiation via the sequential involvement of protein kinase C (PKC) δ and PKCα. In contrast, the FGFR2 isoform switch and the aberrant expression of the mesenchymal FGFR2c isoform leads to impairment of differentiation, epithelial-mesenchymal transition (EMT) and tumorigenic features. Aim of our present study was to contribute in clarifying the complex network of signaling pathways involved in the FGFR2c-mediated oncogenic outcomes focusing on PKCε, which appears to be involved in the induction of EMT and tumorigenesis in several epithelial contexts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00582-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238605PMC

Correction to: PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities.

Cell Commun Signal 2020 May 19;18(1):75. Epub 2020 May 19.

Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

An amendment to this paper has been published and can be accessed via the original article. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00593-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236313PMC

Correction to: Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.

Cell Commun Signal 2020 May 18;18(1):74. Epub 2020 May 18.

State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Yuzhong District, Chongqing, China.

An amendment to this paper has been published and can be accessed via the original article. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00597-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236199PMC

Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells.

Cell Commun Signal 2020 May 12;18(1):72. Epub 2020 May 12.

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Background: Protein neddylation plays a tumor-promoting role in esophageal cancer. Our previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 to promote apoptosis in esophageal cancer cells. However, it is completely unknown whether neddylation inhibition could induce autophagy in esophageal cancer cells and affect the expression of other members of ATF/CREB subfamily, such as ATF3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00576-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218644PMC

Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion.

Cell Commun Signal 2020 May 12;18(1):73. Epub 2020 May 12.

Department of Gynecology of Integrated Traditional Chinese and Western Medicine, Hospital of Obstetrics and Gynecology, Fudan University, Shen Yang Road 128, Shanghai, 200090, People's Republic of China.

Background: The crosstalk between trophoblast cells and decidual NK cells plays an important role in the establishment and maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune tolerance at the maternal fetal interface, while the mechanism remains unclear.

Methods: Autophagy levels in the villi of normal and recurrent spontaneous abortion (RSA) patients were detected by transmission electron microscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00579-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218578PMC

Regulation of efferocytosis as a novel cancer therapy.

Cell Commun Signal 2020 May 5;18(1):71. Epub 2020 May 5.

Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Efferocytosis is a physiologic phagocytic clearance of apoptotic cells, which modulates inflammatory responses and the immune environment and subsequently facilitates immune escape of cancer cells, thus promoting tumor development and progression. Efferocytosis is an equilibrium formed by perfect coordination among "find-me", "eat-me" and "don't-eat-me" signals. These signaling pathways not only affect the proliferation, invasion, metastasis, and angiogenesis of tumor cells but also regulate adaptive responses and drug resistance to antitumor therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00542-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199874PMC

Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.

Cell Commun Signal 2020 May 4;18(1):70. Epub 2020 May 4.

State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Yuzhong District, Chongqing, China.

The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear. We observed CYP1A1 overexpression in peritoneal macrophages (PMs) isolated from mice following LPS or heat-killed Escherichia. coli (E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-0523-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199371PMC
May 2020
3.378 Impact Factor

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.

Cell Commun Signal 2020 May 1;18(1):69. Epub 2020 May 1.

Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland.

Fibroblast growth factors (FGFs) via their receptors (FGFRs) transduce signals from the extracellular space to the cell interior, modulating pivotal cellular processes such as cell proliferation, motility, metabolism and death. FGF superfamily includes a group of fibroblast growth factor homologous factors (FHFs), proteins whose function is still largely unknown. Since FHFs lack the signal sequence for secretion and are unable to induce FGFR-dependent cell proliferation, these proteins were considered as intracellular proteins that are not involved in signal transduction via FGFRs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00573-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193404PMC

The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review.

Cell Commun Signal 2020 Apr 26;18(1):68. Epub 2020 Apr 26.

Department of Colorectal Surgery, Chelsea and Westminster Hospital, NHS Foundation Trust, London, UK.

Background: Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis has been studied in a wide range of cancers. Expression of Neurotensin and its receptors has also been correlated to prognosis and prediction to treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00569-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183616PMC

Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer.

Cell Commun Signal 2020 Apr 22;18(1):67. Epub 2020 Apr 22.

Department of Colorectal Surgery, The Six Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.

Background: Increasing evidence has revealed a close correlation between cancerous inhibitor of protein phosphatase 2A (CIP2A) and cancer progression. CIP2A has been shown to participate in diverse biological processes, such as development, tumorigenic transformation and chemoresistance. However, the functions of CIP2A in colorectal cancer (CRC) and its underlying mechanisms of action are not yet completely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00545-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178757PMC

Correction to: Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.

Cell Commun Signal 2020 Apr 20;18(1):64. Epub 2020 Apr 20.

Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Building 178, Maple Ave, PO Box 70582, Johnson City, TN37614, USA.

An amendment to this paper has been published and can be accessed via the original article. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00577-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168955PMC

Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.

Cell Commun Signal 2020 Apr 20;18(1):65. Epub 2020 Apr 20.

Translational Medicine, School of Health Sciences, University of Skövde, PO Box 408, SE-54128, Skövde, Sweden.

Background: Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mutually exclusive. The DLG2 gene resides in the 11q-deleted region, thus makes it an interesting NB candidate tumor suppressor gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00553-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171851PMC

Suppression of peripheral NGF attenuates neuropathic pain induced by chronic constriction injury through the TAK1-MAPK/NF-κB signaling pathways.

Cell Commun Signal 2020 Apr 20;18(1):66. Epub 2020 Apr 20.

Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China.

Background: Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not been fully elucidated, and the serious adverse events associated with mAbs seriously limit their clinical use. This study further investigated the mechanism by which peripheral NGF is involved in neuropathic pain and found safe, natural compounds that target NGF to attenuate neuropathic pain.

Methods: Nociception was assessed by the Von Frey hair and Hargreaves' methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00556-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171864PMC

Merlin regulates signaling events at the nexus of development and cancer.

Cell Commun Signal 2020 Apr 16;18(1):63. Epub 2020 Apr 16.

Department of Pathology, University of Alabama at Birmingham, WTI 320D, 1824 6th Avenue South, Birmingham, AL, 35233, USA.

Background: In this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 (NF2) gene, orchestrates developmental signaling to ensure normal ontogeny, and we discuss how Merlin deficiency leads to aberrant activation of developmental pathways that enable tumor development and malignant progression.

Main Body: Parallels between embryonic development and cancer have underscored the activation of developmental signaling pathways. Hippo, WNT/β-catenin, TGF-β, receptor tyrosine kinase (RTK), Notch, and Hedgehog pathways are key players in normal developmental biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00544-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164249PMC

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury.

Cell Commun Signal 2020 Apr 15;18(1):62. Epub 2020 Apr 15.

Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Province, Zhejiang, 310009, Hangzhou, China.

Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces structural and functional alterations of astrocytes, the most abundant cell type in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-020-00549-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158016PMC