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    2970 results match your criteria Cell Calcium[Journal]

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    Augmented gene expression triggered by Na(+),K(+)-ATPase inhibition: Role of Ca(2+)i-mediated and -independent excitation-transcription coupling.
    Cell Calcium 2017 Dec 9;68:5-13. Epub 2017 Oct 9.
    Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia; Tomsk National Research University, Tomsk, Russia; Siberian Medical State University, Tomsk, Russia. Electronic address:
    In rat vascular smooth muscle cells (RVSMC), 3-h Na(+),K(+)-ATPase inhibition by ouabain or in K(+)-free medium resulted in the inversion of the [Na(+)]i/[K(+)]i ratio and elevation up to 7-fold the content of Egr1, Atf3, Nr4a1 and Ptgs2 mRNAs. Ouabain increased the rate of 45Ca(2+) influx by 2-fold that was abolished by L-type voltage-gated Ca(2+) channel blocker nicardipine, but it was resistant to Na(+)/Ca(2+) exchanger inhibitor KB-R7943. To study the role of Ca(2+)-mediated signaling in the expression of Na(+)i/K(+)i-sensitive genes we used intracellular Ca(2+) chelator BAPTA and incubated RVSMC in Ca(2+)-free medium. Read More

    Fusion pore in exocytosis: More than an exit gate? A β-cell perspective.
    Cell Calcium 2017 Dec 7;68:45-61. Epub 2017 Nov 7.
    Laboratoire de Chimie et Biologie des Membranes et Nano-objets (CBMN), CNRS UMR 5248, Université de Bordeaux, Allée de Geoffrey St Hilaire, 33600 Pessac, France. Electronic address:
    Secretory vesicle exocytosis is a fundamental biological event and the process by which hormones (like insulin) are released into the blood. Considerable progress has been made in understanding this precisely orchestrated sequence of events from secretory vesicle docked at the cell membrane, hemifusion, to the opening of a membrane fusion pore. The exact biophysical and physiological regulation of these events implies a close interaction between membrane proteins and lipids in a confined space and constrained geometry to ensure appropriate delivery of cargo. Read More

    Differential cytotoxicity and intracellular calcium-signalling following activation of the calcium-permeable ion channels TRPV1 and TRPA1.
    Cell Calcium 2017 Dec 18;68:34-44. Epub 2017 Oct 18.
    Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany. Electronic address:
    Several members of the transient receptor channel (TRP) family can mediate a calcium-dependent cytotoxicity. In sensory neurons, vanilloids like capsaicin induce neurotoxicity by activating TRPV1. The closely related ion channel TRPA1 is also activated by irritants, but it is unclear if and how TRPA1 mediates cell death. Read More

    The steroid hormone 20-hydroxyecdysone upregulates calcium release-activated calcium channel modulator 1 expression to induce apoptosis in the midgut of Helicoverpa armigera.
    Cell Calcium 2017 Dec 20;68:24-33. Epub 2017 Oct 20.
    Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong 250100, China. Electronic address:
    Animal steroid hormones stimulate extracellular Ca(2+) influx into cells; however, the mechanism remains unclear. In this study, we determined that the Ca(2+) influx induced by steroid hormone 20-hydroxyecdysone (20E) is mediated by the calcium release-activated calcium channel modulator 1 (CRACM1/Orai1). The Orai1 mRNA is highly expressed during midgut programmed cell death in the lepidopteran insect Helicoverpa armigera. Read More

    NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.
    Cell Calcium 2017 Dec 29;68:1-4. Epub 2017 Sep 29.
    Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
    Two-pore channels (TPCs) are two-domain members of the voltage-gated ion channel superfamily that localize to acidic organelles. Their mechanism of activation (ligands such as NAADP/PI(3,5)P2 versus voltage) and ion selectivity (Ca(2+) versus Na(+)) is debated. Here we report that a cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth transmembrane region (S4) but to a cytosolic downstream region (S4-S5 linker). Read More

    Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses.
    Cell Calcium 2017 Aug 20. Epub 2017 Aug 20.
    Center for Geroscience, Brain Health and Metabolism, Faculty of Medicine, University of Chile, Chile; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA, 94945, USA; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address:
    Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly regulated as it allows a favorable environment for protein folding, in addition to operate as a major reservoir for fast and specific release of calcium. Altered ER homeostasis impacts protein folding, activating the unfolded protein response (UPR) as a rescue mechanism to restore proteostasis. Read More

    Rho-kinase inhibition reverses impaired Ca(2+) handling and associated left ventricular dysfunction in pressure overload-induced cardiac hypertrophy.
    Cell Calcium 2017 Nov 9;67:81-90. Epub 2017 Sep 9.
    Akdeniz University Faculty of Medicine Department of Biophysics, Antalya, Turkey. Electronic address:
    Recent studies have implicated a relationship between RhoA/ROCK activity and defective Ca(2+) homeostasis in hypertrophic hearts. This study investigated molecular mechanism underlying ROCK inhibition-mediated cardioprotection against pressure overload-induced cardiac hypertrophy, with a focus on Ca(2+) homeostasis. Cardiac hypertrophy model was established by performing transverse aortic constriction (TAC) in 8-week-old male rats. Read More

    High extracellular Ca(2+) enhances the adipocyte accumulation of bone marrow stromal cells through a decrease in cAMP.
    Cell Calcium 2017 Nov 24;67:74-80. Epub 2017 Aug 24.
    Department of Physiology, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
    Bone marrow stromal cells (BMSCs) are common progenitors of both adipocytes and osteoblasts. We recently suggested that increased [Ca(2+)]o caused by bone resorption might accelerate adipocyte accumulation in response to treatment with both insulin and dexamethasone. In this study, we investigated the mechanism by which high [Ca(2+)]o enhances adipocyte accumulation. Read More

    Analyzing optical imaging of Ca(2+) signals via TIRF microscopy: The limits on resolution due to chemical rates and depth of the channels.
    Cell Calcium 2017 Nov 31;67:65-73. Epub 2017 Aug 31.
    T-6 Theoretical Biology and Biophysics Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
    High resolution total internal reflection (TIRF) microscopy (TIRFM) together with detailed computational modeling provides a powerful approach towards the understanding of a wide range of Ca(2+) signals mediated by the ubiquitous inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) channel. Exploiting this fruitful collaboration further requires close agreement between the models and observations. However, elementary Ca(2+) release events, puffs, imaged through TIRFM do not show the rapid single-channel openings and closings during and between puffs as are present in simulated puffs using data-driven single channel models. Read More

    In search for globally disordered apo-parvalbumins: Case of parvalbumin β-1 from coho salmon.
    Cell Calcium 2017 Nov 7;67:53-64. Epub 2017 Sep 7.
    Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; Pushchino State Institute of Natural Sciences, Pushchino, Moscow region, 142290, Russia. Electronic address:
    Parvalbumin (PA) is a classical EF-hand calcium-binding protein of muscle, neuronal, and other tissues, and a major fish allergen. Although certain apo-PAs lack tertiary structure, functional implications of that feature and its structural prerequisites remain unclear. In a search for unstable PAs, we probed conformational stability of parvalbumin β-1 from coho salmon (csPA), a cold water fish species, using circular dichroism, scanning calorimetry, hydrophobic probe fluorescence, limited proteolysis, chemical crosslinking and dynamic light scattering techniques. Read More

    Dynamics of surface neurotransmitter receptors and transporters in glial cells: Single molecule insights.
    Cell Calcium 2017 Nov 25;67:46-52. Epub 2017 Aug 25.
    Interdisciplinary Institute for Neuroscience, CNRS UMR, 5297, Bordeaux, France; University of Bordeaux, Bordeaux, France. Electronic address:
    The surface dynamics of neurotransmitter receptors and transporters, as well as ion channels, has been well-documented in neurons, revealing complex molecular behaviour and key physiological functions. However, our understanding of the membrane trafficking and dynamics of the signalling molecules located at the plasma membrane of glial cells is still in its infancy. Yet, recent breakthroughs in the field of glial cells have been obtained using combination of superresolution microscopy, single molecule imaging, and electrophysiological recordings. Read More

    Vesicle fusion and fission in plants and yeast.
    Cell Calcium 2017 Nov 24;67:40-45. Epub 2017 Aug 24.
    Technische Universität Darmstadt, Fachbereich Biologie, Schnittspahnstrasse 10, 64287 Darmstadt, Germany. Electronic address:
    Measurements of the membrane capacitance on animal cells has provided an excellent technique for monitoring of exo- and endocytotic activity in intact living cells. Here we review recent data in which the same technique was applied to plant cells and cells of the budding yeast Saccharomyces cerevisiae. The data show that unitary exo- and endocytotic events can also be measured with the same technique after removing the cell wall from these cells. Read More

    Differential Ca(2+) mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling.
    Cell Calcium 2017 Nov 12;67:31-39. Epub 2017 Aug 12.
    Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:
    Mast cells play a primary role in allergic diseases. During an allergic reaction, mast cell activation is initiated by cross-linking IgE-FcεRI complex by multivalent antigen resulting in degranulation. Additionally, G protein-coupled receptors also induce degranulation upon activation. Read More

    Early testosterone replacement attenuates intracellular calcium dyshomeostasis in the heart of testosterone-deprived male rats.
    Cell Calcium 2017 Nov 10;67:22-30. Epub 2017 Aug 10.
    Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:
    Background: Testosterone deficiency in elderly men increases the risk of cardiovascular disease. In bilateral orchiectomized (ORX) animals, impaired cardiac Ca(2+) regulation was observed, and this impairment could be improved by testosterone replacement, indicating the important role of testosterone in cardiac Ca(2+) regulation. However, the temporal changes of Ca(2+) dyshomeostasis in testosterone-deprived conditions are unclear. Read More

    A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons.
    Cell Calcium 2017 Nov 25;67:11-20. Epub 2017 Jul 25.
    State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address:
    The brainstem locus coeruleus (LC), the primary norepinephrinergic (NE) nucleus in the brain, has been implicated in the abuse of drugs such as opioids. However, whether and how the LC-NE system is involved in cocaine addiction remains elusive. Here, we demonstrated cocaine-evoked synaptic plasticity of glutamatergic transmission onto LC neurons as one of the earliest traces occurring after a single injection of cocaine. Read More

    Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells.
    Cell Calcium 2017 Nov 29;67:1-10. Epub 2017 Jul 29.
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:
    The control of insulin release from pancreatic beta cells helps ensure proper blood glucose level, which is critical for human health. Protein kinase C has been shown to be one key control mechanism for this process. After glucose stimulation, calcium influx into beta cells triggers exocytosis of insulin-containing dense-core granules and activates protein kinase C via calcium-dependent phospholipase C-mediated generation of diacylglycerol. Read More

    The MCU complex in cell death.
    Cell Calcium 2017 Aug 25. Epub 2017 Aug 25.
    Department of Biomedical Sciences, University of Padova, Italy. Electronic address:
    During the 60s, the notion that positively charged Ca(2+) ions are rapidly accumulated in energized mitochondria has been first established. In the following decades, mitochondrial Ca(2+) homeostasis was shown to control cell metabolism, cell survival and other cell-specific functions through different mechanism. However, the molecular identity of the molecules controlling this process remained a mystery until just few years ago, when both mitochondrial Ca(2+) uptake and release systems were genetically dissected. Read More

    The regulation of autophagy by calcium signals: Do we have a consensus?
    Cell Calcium 2017 Aug 19. Epub 2017 Aug 19.
    School of Life, Health and Chemical Sciences, The Open University, MK7 6AA, UK.
    Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates via vesicular engulfment of cellular materials and culminates in their degradation via lysosomal hydrolases, with the whole process often being termed 'autophagic flux'. Autophagy is a multi-step pathway requiring the interplay of numerous scaffolding and signalling molecules. Read More

    Mitochondrial Ca(2+)-activated K(+) channels and their role in cell life and death pathways.
    Cell Calcium 2017 Jul 22. Epub 2017 Jul 22.
    Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, Department of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands. Electronic address:
    Ca(2+)-activated K(+) channels (KCa) are expressed at the plasma membrane and in cellular organelles. Expression of all KCa channel subtypes (BK, IK and SK) has been detected at the inner mitochondrial membrane of several cell types. Primary functions of these mitochondrial KCa channels include the regulation of mitochondrial ROS production, maintenance of the mitochondrial membrane potential and preservation of mitochondrial calcium homeostasis. Read More

    Total internal reflectance fluorescence imaging of genetically engineered ryanodine receptor-targeted Ca(2+) probes in rat ventricular myocytes.
    Cell Calcium 2017 Sep 19;66:98-110. Epub 2017 Jul 19.
    Cardiac Signaling Center of University of South Carolina, Clemson University and Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:
    The details of cardiac Ca(2+) signaling within the dyadic junction remain unclear because of limitations in rapid spatial imaging techniques, and availability of Ca(2+) probes localized to dyadic junctions. To critically monitor ryanodine receptors' (RyR2) Ca(2+) nano-domains, we combined the use of genetically engineered RyR2-targeted pericam probes, (FKBP-YCaMP, Kd=150nM, or FKBP-GCaMP6, Kd=240nM) with rapid total internal reflectance fluorescence (TIRF) microscopy (resolution, ∼80nm). The punctate z-line patterns of FKBP,(2)-targeted probes overlapped those of RyR2 antibodies and sharply contrasted to the images of probes targeted to sarcoplasmic reticulum (SERCA2a/PLB), or cytosolic Fluo-4 images. Read More

    C1q/tumor necrosis factor-related protein-3 enhances the contractility of cardiomyocyte by increasing calcium sensitivity.
    Cell Calcium 2017 Sep 8;66:90-97. Epub 2017 Jul 8.
    Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China. Electronic address:
    C1q/tumor necrosis factor-related protein-3 (CTRP3) is an adipokine that protects against myocardial infarction-induced cardiac dysfunction through its pro-angiogenic, anti-apoptotic, and anti-fibrotic effects. However, whether CTRP3 can directly affect the systolic and diastolic function of cardiomyocytes remains unknown. Adult rat cardiomyocytes were isolated and loaded with Fura-2AM. Read More

    Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability.
    Cell Calcium 2017 Sep 9;66:78-89. Epub 2017 Jun 9.
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People's Republic of China; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. Electronic address:
    Eukaryotic thrombospondin type 3 repeat (TT3R) is an efficient calcium ion (Ca(2+)) binding motif only found in mammalian thrombospondin family. TT3R has also been found in prokaryotic cellulase Cel5G, which was thought to forfeit the Ca(2+)-binding capability due to the formation of intra-repeat disulfide bonds, instead of the inter-repeat ones possessed by eukaryotic TT3Rs. In this study, we have identified an enormous number of prokaryotic TT3R-containing proteins belonging to several different protein families, including outer membrane protein A (OmpA), an important structural protein connecting the outer membrane and the periplasmic peptidoglycan layer in gram-negative bacteria. Read More

    Exocytotic fusion pores as a target for therapy.
    Cell Calcium 2017 Sep 19;66:71-77. Epub 2017 Jun 19.
    Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia; Celica Biomedical Center, Tehnološki park 24, 1000 Ljubljana, Slovenia. Electronic address:
    Regulated exocytosis can be split into a sequence of steps ending with the formation and the dilation of a fusion pore, a neck-like connection between the vesicle and the plasma membrane. Each of these steps is precisely controlled to achieve the optimal spatial and temporal profile of the release of signalling molecules. At the level of the fusion pore, tuning of the exocytosis can be achieved by preventing its formation, by stabilizing the unproductive narrow fusion pore, by altering the speed of fusion pore expansion and by completely closing the fusion pore. Read More

    Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin.
    Cell Calcium 2017 Sep 6;66:62-70. Epub 2017 Jun 6.
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States; Cardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, United States. Electronic address:
    The mammalian ryanodine receptor Ca(2+) release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca(2+). This suggests isoform-specific domains are involved in RyR regulation by CaM. Read More

    Muscling in on TRP channels in vascular smooth muscle cells and cardiomyocytes.
    Cell Calcium 2017 Sep 15;66:48-61. Epub 2017 Jun 15.
    Laboratory of Ion Channel Research, TRP Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium. Electronic address:
    The human TRP protein family comprises a family of 27 cation channels with diverse permeation and gating properties. The common theme is that they are very important regulators of intracellular Ca(2+) signaling in diverse cell types, either by providing a Ca(2+) influx pathway, or by depolarising the membrane potential, which on one hand triggers the activation of voltage-gated Ca(2+) channels, and on the other limits the driving force for Ca(2+) entry. Here we focus on the role of these TRP channels in vascular smooth muscle and cardiac striated muscle. Read More

    Acetylcholine induces intracellular Ca(2+) oscillations and nitric oxide release in mouse brain endothelial cells.
    Cell Calcium 2017 Sep 12;66:33-47. Epub 2017 Jun 12.
    Laboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy. Electronic address:
    Basal forebrain neurons increase cortical blood flow by releasing acetylcholine (Ach), which stimulates endothelial cells (ECs) to produce the vasodilating gasotransmitter, nitric oxide (NO). Surprisingly, the mechanism whereby Ach induces NO synthesis in brain microvascular ECs is unknown. An increase in intracellular Ca(2+) concentration recruits a multitude of endothelial Ca(2+)-dependent pathways, such as Ca(2+)/calmodulin endothelial NO synthase (eNOS). Read More

    TRPP2 ion channels: Critical regulators of organ morphogenesis in health and disease.
    Cell Calcium 2017 Sep 1;66:25-32. Epub 2017 Jun 1.
    Renal Division, Department of Medicine, Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany. Electronic address:
    Ion channels control the membrane potential and mediate transport of ions across membranes. Archetypical physiological functions of ion channels include processes such as regulation of neuronal excitability, muscle contraction, or transepithelial ion transport. In that regard, transient receptor potential ion channel polycystin 2 (TRPP2) is remarkable, because it controls complex morphogenetic processes such as the establishment of properly shaped epithelial tubules and left-right-asymmetry of organs. Read More

    TRP channel pores and local calcium signals.
    Cell Calcium 2017 Sep 30;66:19-24. Epub 2017 May 30.
    Lab of Ion Channel Research (LICR), KU Leuven, Herestraat 49, Box 802, B-3000 Leuven, Belgium. Electronic address:
    Calcium signals control a plethora of essential cellular functions ranging from secretion and contraction to gene expression and sensory signaling cascades. An essential part of intracellular calcium signals originates from the transmembrane flux of calcium ions, which is mainly mediated through different calcium-permeable cation channels with variable calcium selectivity. Opening of individual calcium permeable channels induces a local cytosolic calcium rise that can be highly restricted in time and space. Read More

    A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels.
    Cell Calcium 2017 Sep 2;66:10-18. Epub 2017 Jun 2.
    Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, Härtelstraße 16-18, 04107 Leipzig, Germany. Electronic address:
    The transient receptor potential canonical channel 5 (TRPC5) is a Ca(2+)-permeable ion channel, which is predominantly expressed in the brain. TRPC5-deficient mice exhibit a reduced innate fear response and impaired motor control. In addition, outgrowth of hippocampal and cerebellar neurons is retarded by TRPC5. Read More

    Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway.
    Cell Calcium 2017 Sep 15;66:1-9. Epub 2017 May 15.
    Departamento de Biología Celular, Cinvestav-IPN, Ciudad de México, Mexico. Electronic address:
    cGMP is a second messenger widely used in the nervous system and other tissues. One of the major effectors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein kinase (PKG), which catalyzes the phosphorylation of a variety of proteins including ion channels. Previously, it has been shown that the cGMP-PKG signaling pathway inhibits Ca(2+) currents in rat vestibular hair cells and chromaffin cells. Read More

    Calcium signaling and cell cycle: Progression or death.
    Cell Calcium 2017 Jul 25. Epub 2017 Jul 25.
    Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Institut National de la Santé et de la Recherche Médicale, U1138, Paris, France; Université Pierre et Marie Curie, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Electronic address:
    Cytosolic Ca(2+) concentration levels fluctuate in an ordered manner along the cell cycle, in line with the fact that Ca(2+) is involved in the regulation of cell proliferation. Cell proliferation should be an error-free process, yet is endangered by mistakes. In fact, a complex network of proteins ensures that cell cycle does not progress until the previous phase has been successfully completed. Read More

    TRPs and Ca(2+) in cell death and survival.
    Cell Calcium 2017 Jul 15. Epub 2017 Jul 15.
    Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq 59656, France. Electronic address:
    Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to environmental stimuli. Pharmacological or genetic manipulations of TRP channels demonstrate that TRP channels influence cell death rates, prolonging or shortening of cell survival. Due to their diverse cellular localization, TRP channels mediated Ca(2+) influx generates distinct intracellular Ca(2+) signals that regulate downstream pathways converging to apoptosis or survival. Read More

    SERCA control of cell death and survival.
    Cell Calcium 2017 Jul 12. Epub 2017 Jul 12.
    Cardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Diabetes, Obesity and Metabolism Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Graduate School of Biological Sciences, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
    Intracellular calcium (Ca(2+)) is a critical coordinator of various aspects of cellular physiology. It is increasingly apparent that changes in cellular Ca(2+) dynamics contribute to the regulation of normal and pathological signal transduction that controls cell growth and survival. Aberrant perturbations in Ca(2+) homeostasis have been implicated in a range of pathological conditions, such as cardiovascular diseases, diabetes, tumorigenesis and steatosis hepatitis. Read More

    Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.
    Cell Calcium 2017 Jun 30. Epub 2017 Jun 30.
    Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter The Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation; Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address:
    Calcium (Ca(2+)) is a ubiquitous second messenger that regulates various activities in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons require extremely precise spatial-temporal control of calcium-dependent processes because they regulate such vital functions as synaptic plasticity. Read More

    VDAC1 functions in Ca(2+) homeostasis and cell life and death in health and disease.
    Cell Calcium 2017 Jun 23. Epub 2017 Jun 23.
    Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
    In the outer mitochondrial membrane (OMM), the voltage-dependent anion channel 1 (VDAC1) serves as a mitochondrial gatekeeper, controlling the metabolic and energy cross-talk between mitochondria and the rest of the cell. VDAC1 also functions in cellular Ca(2+) homeostasis by transporting Ca(2+) in and out of mitochondria. VDAC1 has also been recognized as a key protein in mitochondria-mediated apoptosis, contributing to the release of apoptotic proteins located in the inter-membranal space (IMS) and regulating apoptosis via association with pro- and anti-apoptotic members of the Bcl-2 family of proteins and hexokinase. Read More

    Bcl-2 inhibitors as anti-cancer therapeutics: The impact of and on calcium signaling.
    Cell Calcium 2017 Jun 4. Epub 2017 Jun 4.
    KU Leuven, Laboratory of Molecular and Cellular Signaling, Campus Gasthuisberg O/N-I bus 802, Herestraat 49, B-3000 Leuven, Belgium; Leuven Kanker Instituut (LKI), Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Electronic address:
    Bcl-2-protein family members are essential regulators of apoptosis. Anti-apoptotic Bcl-2 proteins ensure cell survival via different mechanisms, including via binding of pro-apoptotic Bcl-2-family members and the modulation of intracellular Ca(2+)-transport systems. Many cancer cells upregulate these proteins to overcome the consequences of ongoing oncogenic stress. Read More

    TRPML1: The Ca((2+))retaker of the lysosome.
    Cell Calcium 2017 Jun 24. Epub 2017 Jun 24.
    Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli ,NA, Italy. Electronic address:
    Efficient functioning of lysosome is necessary to ensure the correct performance of a variety of intracellular processes such as degradation of cargoes coming from the endocytic and autophagic pathways, recycling of organelles, and signaling mechanisms involved in cellular adaptation to nutrient availability. Mutations in lysosomal genes lead to more than 50 lysosomal storage disorders (LSDs). Among them, mutations in the gene encoding TRPML1 (MCOLN1) cause Mucolipidosis type IV (MLIV), a recessive LSD characterized by neurodegeneration, psychomotor retardation, ophthalmologic defects and achlorhydria. Read More

    Role of SOCE architects STIM and Orai proteins in Cell Death.
    Cell Calcium 2017 Jun 9. Epub 2017 Jun 9.
    Systems Biology Group, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110025, India. Electronic address:
    Calcium (Ca(2+)) signaling plays a critical role in regulating plethora of cellular functions including cell survival, proliferation and migration. The perturbations in cellular Ca(2+) homeostasis can lead to cell death either by activating autophagic pathways or through induction of apoptosis. Endoplasmic reticulum (ER) is the major storehouse of Ca(2+) within cells and a number of physiological agonists mediate ER Ca(2+) release by activating IP3 receptors (IP3R). Read More

    Metabolic regulation of the PMCA: Role in cell death and survival.
    Cell Calcium 2017 Jun 8. Epub 2017 Jun 8.
    Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom. Electronic address:
    The plasma membrane Ca(2+)-ATPase (PMCA) is a ubiquitously expressed, ATP-driven Ca(2+) pump that is critical for maintaining low resting cytosolic Ca(2+) ([Ca(2+)]i) in all eukaryotic cells. Since cytotoxic Ca(2+) overload has such a central role in cell death, the PMCA represents an essential "linchpin" for the delicate balance between cell survival and cell death. In general, impaired PMCA activity and reduced PMCA expression leads to cytotoxic Ca(2+) overload and Ca(2+) dependent cell death, both apoptosis and necrosis, whereas maintenance of PMCA activity or PMCA overexpression is generally accepted as being cytoprotective. Read More

    Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death.
    Cell Calcium 2017 May 31. Epub 2017 May 31.
    Faculty of Medicine and Dentistry, Department of Cell Biology, University of Alberta, Edmonton, T6G2H7, Canada,. Electronic address:
    The folding of secretory proteins is a well-understood mechanism, based on decades of research on endoplasmic reticulum (ER) chaperones. These chaperones interact with newly imported polypeptides close to the ER translocon. Classic examples for these proteins include the immunoglobulin binding protein (BiP/GRP78), and the lectins calnexin and calreticulin. Read More

    Polycystin and calcium signaling in cell death and survival.
    Cell Calcium 2017 May 24. Epub 2017 May 24.
    Department of Pharmacology, Yale University, 333 Cedar St, New Haven, CT, 06520, USA; Department of Cellular and Molecular Physiology, Yale University, 333 Cedar St, New Haven, CT, 06520, USA. Electronic address:
    Mutations in polycystin-1 (PC1) and polycystin-2 (PC2) result in a commonly occurring genetic disorder, called Autosomal Dominant Polycystic Kidney Disease (ADPKD), that is characterized by the formation and development of kidney cysts. Epithelial cells with loss-of-function of PC1 or PC2 show higher rates of proliferation and apoptosis and reduced autophagy. PC1 is a large multifunctional transmembrane protein that serves as a sensor that is usually found in complex with PC2, a calcium (Ca(2+))-permeable cation channel. Read More

    Ca(2+) signaling, apoptosis and autophagy in the developing cochlea: Milestones to hearing acquisition.
    Cell Calcium 2017 May 11. Epub 2017 May 11.
    Department of Physics and Astronomy "G. Galilei", University of Padua, 35131 Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Foundation for Advanced Biomedical Research, 35129 Padua, Italy; Department of Biomedical Sciences, Institute of Protein Biochemistry, Italian National Research Council, 80131 Naples (NA), Italy.
    In mammals, the sense of hearing arises through a complex sequence of morphogenetic events that drive the sculpting of the auditory sensory epithelium into its terminally functional three-dimensional shape. While the majority of the underlying mechanisms remain unknown, it has become increasingly clear that Ca(2+) signaling is at center stage and plays numerous fundamental roles both in the sensory hair cells and in the matrix of non-sensory, epithelial and supporting cells, which embed them and are tightly interconnected by a dense network of gap junctions formed by connexin 26 (Cx26) and connexin 30 (Cx30) protein subunits. In this review, we discuss the intricate interplay between Ca(2+) signaling, connexin expression and function, apoptosis and autophagy in the crucial steps that lead to hearing acquisition. Read More

    Genetic strategies to analyze primary TRP channel-expressing cells in mice.
    Cell Calcium 2017 Nov 17;67:91-104. Epub 2017 May 17.
    Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany. Electronic address:
    Transient receptor potential (TRP) ion channels regulate fundamental biological processes throughout the body. TRP channel dysfunction has been causally linked to a number of disease states and thus establishes these channels as promising therapeutic targets. In order to dissect the physiological role of individual TRP channels in specific tissues, a detailed understanding of the expression pattern of the different TRP channels throughout the organism is essential. Read More

    Ca(2+) signalling underlying pancreatitis.
    Cell Calcium 2017 May 18. Epub 2017 May 18.
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK. Electronic address:
    In spite of significant scientific progress in recent years, acute pancreatitis (AP) is still a dangerous and in up to 5% of cases deadly disease with no specific cure. It is self-resolved in the majority of cases, but could result in chronic pancreatitis (CP) and increased risk of pancreatic cancer (PC). One of the early events in AP is premature activation of digestive pro-enzymes, including trypsinogen, inside pancreatic acinar cells (PACs) due to an excessive rise in the cytosolic Ca(2+) concentration, which is the result of Ca(2+) release from internal stores followed by Ca(2+) entry through the store operated Ca(2+) channels in the plasma membrane. Read More

    TRPM channels as potential therapeutic targets against pro-inflammatory diseases.
    Cell Calcium 2017 Nov 3;67:105-115. Epub 2017 May 3.
    Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany.
    The immune system protects our body against foreign pathogens. However, if it overshoots or turns against itself, pro-inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, or diabetes develop. Ions, the most basic signaling molecules, shape intracellular signaling cascades resulting in immune cell activation and subsequent immune responses. Read More

    The role of Ca(2+) in cell death caused by oxidative glutamate toxicity and ferroptosis.
    Cell Calcium 2017 May 12. Epub 2017 May 12.
    University Medical Center and Focus Program Translational Neuroscience (FTN) of the Johannes Gutenberg University Mainz, Department of Neurology, Mainz, Germany. Electronic address:
    Ca(2+) ions play a fundamental role in cell death mediated by oxidative glutamate toxicity or oxytosis, a form of programmed cell death similar and possibly identical to other forms of cell death like ferroptosis. Ca(2+) influx from the extracellular space occurs late in a cascade characterized by depletion of the intracellular antioxidant glutathione, increases in cytosolic reactive oxygen species and mitochondrial dysfunction. Here, we aim to compare oxidative glutamate toxicity with ferroptosis, address the signaling pathways that culminate in Ca(2+) influx and cell death and discuss the proteins that mediate this. Read More

    Calcium and regulation of the mitochondrial permeability transition.
    Cell Calcium 2017 05 10. Epub 2017 May 10.
    Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy. Electronic address:
    Recent years have seen renewed interest in the permeability transition pore, a high conductance channel responsible for permeabilization of the inner mitochondrial membrane, a process that leads to depolarization and Ca(2+) release. Transient openings may be involved in physiological Ca(2+) homeostasis while long-lasting openings may trigger and/or execute cell death. In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca(2+) can reversibly switch this energy-conserving nanomachine into an energy-dissipating device. Read More

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