2,068 results match your criteria Cell Biology of Head and Neck Squamous Cell Carcinoma


The significance of tumor budding in oral cancer survival and its relevance to the eighth edition of the American Joint Committee on Cancer staging system.

Head Neck 2019 Apr 23. Epub 2019 Apr 23.

Department of Stomatology, Oral & Maxillofacial Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: To explore the clinicopathological significance of tumor budding (TB) on oral squamous cell carcinoma (OSCC) prognosis.

Methods: Data of 200 patients with OSCC were retrieved from the cancer registration database in Taipei Veterans General Hospital. Clinicopathological characteristics and survival relevant to TB were analyzed. Read More

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http://dx.doi.org/10.1002/hed.25780DOI Listing

Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.

Mol Ther Oncolytics 2019 Sep 20;14:57-65. Epub 2019 Mar 20.

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.

Oral radiotoxicity is often a limiting factor in cancer treatment. Previously, we demonstrated that transfer of cell-permeable, TAT-fusion Tousled-like kinase 1B (TLK1B) protein in salivary glands effectively mitigates radiation-induced salivary dysfunction. However, similar to most radioprotectors, TLK1B can carry the risk of limiting cancer treatment efficacy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23727705193001
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http://dx.doi.org/10.1016/j.omto.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463741PMC
September 2019
1 Read

Oncogenic Role of ZFAS1 lncRNA in Head and Neck Squamous Cell Carcinomas.

Cells 2019 Apr 21;8(4). Epub 2019 Apr 21.

Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, 15 Garbary Street, 61-866 Poznan, Poland.

Background: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with high mortality. The identification of specific HNSCC biomarkers will increase treatment efficacy and limit the toxicity of current therapeutic strategies. Long non-coding RNAs (lncRNAs) are promising biomarkers. Read More

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http://dx.doi.org/10.3390/cells8040366DOI Listing

Identification of key candidate genes and pathways in oral squamous cell carcinoma by integrated Bioinformatics analysis.

Exp Ther Med 2019 May 26;17(5):4089-4099. Epub 2019 Mar 26.

Department of Oral Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong 250100, P.R. China.

Oral squamous cell carcinoma (OSCC) is one of the most common types of malignant head and neck tumor, which poses a serious threat to human health. In recent years, the incidence of OSCC has been increasing, while the prognosis has not significantly improved. Elucidation of the molecular mechanisms underlying the development of OSCC may provide novel therapeutic strategies. Read More

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http://dx.doi.org/10.3892/etm.2019.7442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468404PMC

Increasing incidence rates of oropharyngeal squamous cell carcinoma in Germany and significance of disease burden attributed to human papillomavirus.

Cancer Prev Res (Phila) 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Cologne.

Increasing incidences of head and neck cancers and rising proportions of these associated with human papilloma virus (HPV), especially in the oropharynx, have been reported in international studies. So far, the trends and contribution of HPV to the number of newly diagnosed cases of oropharyngeal squamous cell carcinomas (OPSCC) in Germany are uncertain. We investigated HPV association and incidence rates in a cohort of consecutively included patients with OPSCC in Giessen 2000-2017, and compared our results with regional (Giessen and the federal state of Hesse), national (Germany) and international (USA) databases. Read More

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0098DOI Listing
April 2019
1 Read

Innervation of cervical carcinoma is mediated by cancer-derived exosomes.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Sanford Research, Cancer Biology and Immunotherapy Group, 2301 East 60th St north, Sioux Falls, SD 57104, USA. Electronic address:

Objective: Recently, our laboratory identified sensory innervation within head and neck squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby HNSCCs promote their own innervation via the release of exosomes that stimulate neurite outgrowth. Interestingly, we noted that exosomes from human papillomavirus (HPV)-positive cell lines were more effective at promoting neurite outgrowth than those from HPV-negative cell lines. As nearly all cervical tumors are HPV-positive, we hypothesized that these findings would extend to cervical cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193114
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http://dx.doi.org/10.1016/j.ygyno.2019.04.651DOI Listing
April 2019
1 Read

Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma.

PLoS One 2019 19;14(4):e0215770. Epub 2019 Apr 19.

Departments of Medicine and Biochemistry & the Stony Brook Cancer Center at Stony Brook University, Stony Brook, New York, United States of America.

The purpose of this study was to determine the profile of bioactive sphingolipids in xenograft mouse tissues of head and neck squamous cell carcinoma. We utilized UHPLC-MS/MS to determine the profile of full set of ceramides, sphingosine, and sphingosine 1-phosphate in this xenograft mouse model. The tissues isolated and investigated were from brain, lung, heart, liver, spleen, kidney, bladder, tumors and blood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215770PLOS

A Six-Gene-Based Prognostic Model Predicts Survival in Head and Neck Squamous Cell Carcinoma Patients.

J Maxillofac Oral Surg 2019 Jun 24;18(2):320-327. Epub 2019 Jan 24.

3Department of Pathology, The University of Iowa, 500 Newton Road, #ML 1132, Iowa City, IA 52242-5000 USA.

Background And Objective: Head and neck cancer is a malignant tumor that begins in the head and neck region, and has the sixth highest incidence worldwide. Previous studies have indicated several prognostic markers for head and neck squamous cell carcinoma (HNSCC), but due to poor accuracy and sensitivity of these clinical characteristic markers attention has been gradually switched to molecular biomarkers. This study aimed to sort out the mRNAs correlated with patient survival time to establish an mRNA combination prognostic biomarker model for HNSCC patient risk stratification, providing optimal therapeutic regimens and improving patient prognosis. Read More

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http://dx.doi.org/10.1007/s12663-019-01187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441444PMC

Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy.

Clin Transl Radiat Oncol 2019 May 18;16:40-47. Epub 2019 Mar 18.

German Cancer Consortium (DKTK) Partner Site Dresden, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Objective: To independently validate the impact of tumour volume, p16 status, cancer stem cell (CSC) marker expression and hypoxia-associated gene signatures as potential prognostic biomarkers for patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who underwent primary radiotherapy or radiochemotherapy (RCTx). These markers have previously been reported in a study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) (Linge et al., 2016). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056308183011
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http://dx.doi.org/10.1016/j.ctro.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449705PMC
May 2019
2 Reads

Induction of squamous cell carcinoma after MAP3K8 overexpression in murine salivary gland epithelial cells.

Head Neck 2019 May;41(5):1547

Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1002/hed.25770DOI Listing

Targeted Therapies and Immune-Checkpoint Inhibition in Head and Neck Squamous Cell Carcinoma: Where Do We Stand Today and Where to Go?

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

Department of Radiation Oncology, Rämistrasse 100, University Hospital Zurich, 8091 Zürich, Switzerland.

With an increased understanding of the tumor biology of squamous cell carcinoma of the head and neck (SCCHN), targeted therapies have found their way into the clinical treatment routines against this entity. Nevertheless, to date platinum-based cytostatic agents remain the first line choice and targeting the epidermal growth factor-receptor (EGFR) with combined cetuximab and radiation therapy remains the only targeted therapy approved in the curative setting. Investigation of immune checkpoint inhibitors (ICI), such as antibodies targeting programmed cell death protein 1 (PD-1) and its ligand PD-L1, resulted in a change of paradigms in oncology and in the first approval of new drugs for treating SCCHN. Read More

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http://dx.doi.org/10.3390/cancers11040472DOI Listing
April 2019
1 Read

Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.

Cancers (Basel) 2019 Apr 7;11(4). Epub 2019 Apr 7.

Medical Oncology Service, University Hospital of Salamanca-IBSAL, 37007 Salamanca, Spain.

Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Read More

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http://dx.doi.org/10.3390/cancers11040493DOI Listing
April 2019
1 Read

Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Arch Dermatol Res 2019 Apr 6. Epub 2019 Apr 6.

Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.

The interaction of lectin-like transcript 1 (LLT1) with CD161 inhibits Natural Killer cell activation. Overexpression of LLT1 contributes to the immunosuppressive properties of tumor cells. However, there are little data about LLT1 expression in human solid tumors. Read More

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http://dx.doi.org/10.1007/s00403-019-01916-xDOI Listing
April 2019
1 Read

MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.

Pathol Oncol Res 2019 Apr 4. Epub 2019 Apr 4.

Department of Central Laboratory, School of Stomatology, China Medical University, 117 North Nanjing Street, Heping District, Shenyang, 110002, Liaoning, China.

Oral squamous cell carcinoma (OSCC) characterized with invasive growth, local metastasis and later stage diagnosis was a common malignancy in head and neck region. The aim of this study was to explore the relationship between miR-182-5p and OSCC, which will contribute to find potential biomarker for OSCC metastasis. MiR-182-5p expression level was detected by the quantitative real-time PCR (qRT-PCR). Read More

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http://dx.doi.org/10.1007/s12253-019-00647-8DOI Listing

Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas.

World J Clin Oncol 2019 Mar;10(3):136-148

Department of Otorhinolaryngology, Ludwig-Maximilians-University, Munich 81377, Germany.

Background: Head and neck squamous cell carcinoma (HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases (RTKs) and members of the fibroblast growth factor receptors (FGFR)-family. Single-nucleotide polymorphism (SNP) Arg388 of the FGFR4 is associated with a reduced overall survival in patients with cancers of various types. We speculate that FGFR4 expression and SNP is associated with worse survival in patients with HSNCC. Read More

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http://dx.doi.org/10.5306/wjco.v10.i3.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441662PMC
March 2019
4 Reads

Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.

Am J Cancer Res 2019 1;9(3):479-495. Epub 2019 Mar 1.

Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou 510080, P. R. China.

Nasopharyngeal carcinoma (NPC), arising from the nasopharynx epithelium, is prevalent among South and East Asia. The radiotherapy is the primary treatment for NPC patients. However, the acquired radioresistance dramatically diminishes the therapeutic effect of radiotherapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448059PMC
March 2019
2 Reads

The role of the T-N tract in advanced stage tongue cancer.

Head Neck 2019 Apr 3. Epub 2019 Apr 3.

Division of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, Milan, Italy.

Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage.

Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25761
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http://dx.doi.org/10.1002/hed.25761DOI Listing
April 2019
3 Reads

Genetic Factors Associated with a Poor Outcome in Head and Neck Cancer Patients Receiving Definitive Chemoradiotherapy.

Cancers (Basel) 2019 Mar 29;11(4). Epub 2019 Mar 29.

Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

About half of advanced stage head and neck squamous cell carcinoma (HNSCC) patients can be cured by chemoradiotherapy. Patient outcome may be partially determined by the genetic alterations in HNSCC, rendering these alterations promising candidate prognostic factors and/or therapeutic targets. However, their relevance in patient outcome prognosis remains to be assessed in patients that receive standard-of-care chemoradiotherapy. Read More

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https://www.mdpi.com/2072-6694/11/4/445
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http://dx.doi.org/10.3390/cancers11040445DOI Listing
March 2019
6 Reads

Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus-positive oropharyngeal squamous cell carcinoma.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Moores Cancer Center, University of California San Diego, La Jolla, California.

Background: Human papillomavirus (HPV)-associated oropharyngeal cancer is a disease clinically and biologically distinct from smoking-related head and neck squamous cell carcinoma (HNSCC). Despite its rapidly increasing incidence, the mutational landscape of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) remains understudied.

Methods: This article presents the first mutational analysis of the 46 HPV+ OPSCC tumors within the newly expanded cohort of 530 HNSCC tumors from The Cancer Genome Atlas. Read More

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http://dx.doi.org/10.1002/cncr.32068DOI Listing
April 2019
4 Reads

PTEN loss is associated with resistance to cetuximab in patients with head and neck squamous cell carcinoma.

Oral Oncol 2019 Apr 4;91:69-78. Epub 2019 Mar 4.

Department of Medicine, Yale University School of Medicine and Yale Cancer Center, United States. Electronic address:

Introduction: Cetuximab, a monoclonal antibody to the epidermal growth factor receptor (EGFR), extends survival in combination with standard therapy in head and neck squamous cell carcinoma (HNSCC). However, as effects are modest, and patients experience side effects, a biomarker to predict resistance and personalize therapy is needed. Activation of signaling pathways downstream from receptor tyrosine kinases predicts resistance to such therapies in other cancers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193007
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http://dx.doi.org/10.1016/j.oraloncology.2019.02.026DOI Listing
April 2019
3 Reads

miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells.

J Exp Clin Cancer Res 2019 Mar 29;38(1):141. Epub 2019 Mar 29.

Oncogenomics and Epigenetics Unit, IRCCS-Regina Elena National Cancer Institute, 00144, Rome, Italy.

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. They are typically characterized by a high incidence of local recurrence, which is the most common cause of death in HNSCC patients. TP53 is the most frequently mutated gene in HNSCC and patients carrying TP53 mutations are associated with a higher probability to develop local recurrence. Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1119-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440033PMC
March 2019
5 Reads

Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis.

mSphere 2019 03 27;4(2). Epub 2019 Mar 27.

Division of Viral Transformation Mechanisms, German Cancer Research Center (DKFZ), Heidelberg, Germany

Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV and oncogenes on host cells, ultimately leading to malignant transformation. Here, we used newly established immortalized human keratinocytes with a well-defined HPV16 expression cassette to get a more complete and less biased overview of global changes induced by HPV16 by employing transcriptome sequencing (RNA-Seq) and stable isotope labeling by amino acids in cell culture (SILAC). This is the first study combining transcriptome and proteome data to characterize the impact of HPV oncogenes in human keratinocytes in comparison with their virus-negative counterparts. Read More

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http://dx.doi.org/10.1128/mSphere.00129-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437273PMC
March 2019
1 Read

Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma.

Int J Mol Sci 2019 Mar 26;20(6). Epub 2019 Mar 26.

University of Zurich, Institute of Oral Biology, Plattenstrasse 11, CH-8032 Zurich, Switzerland.

Head and neck squamous cell carcinoma (HNSCC) defines a group of solid tumors originating from the mucosa of the upper aerodigestive tract, pharynx, larynx, mouth, and nasal cavity. It has a metastatic evolution and poor prognosis and is the sixth most common cancer in the world, with 600,000 new cases reported every year. HNSCC heterogeneity and complexity is reflected in a multistep progression, involving crosstalk between several molecular pathways. Read More

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http://dx.doi.org/10.3390/ijms20061520DOI Listing
March 2019
1 Read

Expression level and prospective mechanism of miRNA-99a-3p in head and neck squamous cell carcinoma based on miRNA-chip and miRNA-sequencing data in 1, 167 cases.

Pathol Res Pract 2019 May 4;215(5):963-976. Epub 2019 Feb 4.

Department of Otolaryngology Head and Neck Surgery, 303 Hospital of PLA Guangxi Zhuang Autonomous Region, Nanning, China. Electronic address:

Background: The role of miR-99a-3p in Head and neck squamous cell carcinoma (HNSCC) has not been reported. Therefore, in this study, we examined the expression level and its molecular mechanisms of miR-99a-3p in HNSCC.

Materials And Methods: MiR-99a-3p-related miRNA-chip and miRNA-sequencing data were collected. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.002DOI Listing

Targeting cellular metabolism to reduce head and neck cancer growth.

Sci Rep 2019 Mar 21;9(1):4995. Epub 2019 Mar 21.

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, 10010, USA.

Head and neck squamous cell carcinoma (HNSCC) presents a major public health concern because of delayed diagnosis and poor prognosis. Malignant cells often reprogram their metabolism in order to promote their survival and proliferation. Aberrant glutaminase 1 (GLS1) expression enables malignant cells to undergo increased glutaminolysis and utilization of glutamine as an alternative nutrient. Read More

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http://www.nature.com/articles/s41598-019-41523-4
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http://dx.doi.org/10.1038/s41598-019-41523-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428890PMC
March 2019
9 Reads

TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility.

PLoS One 2019 20;14(3):e0213463. Epub 2019 Mar 20.

National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.

Distant metastasis leads oral cancer patients into a poor survival rate and a high recurrence stage. During tumor progression, dysregulated microRNAs (miRNAs) have been reported to involve tumor initiation and modulate oral cancer malignancy. MiR-450a was significantly upregulated in oral squamous cell carcinoma (OSCC) patients without functional reports. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213463PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426234PMC
March 2019
2 Reads

Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma.

J Immunother Cancer 2019 Mar 19;7(1):79. Epub 2019 Mar 19.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA, 52242, USA.

Background: Despite the high prevalence of epidermal growth factor receptor (EGFR) overexpression in head and neck squamous cell carcinomas (HNSCCs), incorporation of the EGFR inhibitor cetuximab into the clinical management of HNSCC has not led to significant changes in long-term survival outcomes. Therefore, the identification of novel therapeutic approaches to enhance the clinical efficacy of cetuximab could lead to improved long-term survival for HNSCC patients. Our previous work suggests that EGFR inhibition activates the interleukin-1 (IL-1) pathway via tumor release of IL-1 alpha (IL-1α), although the clinical implications of activating this pathway are unclear in the context of cetuximab therapy. Read More

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http://dx.doi.org/10.1186/s40425-019-0550-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425573PMC

Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma.

Am J Otolaryngol 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21151 Pomerantz Family Pavilion, 200 Hawkins Drive, 52240, Iowa City, IA, USA.

Merkel cell carcinoma (MCC) is a neuroendocrine cutaneous malignancy that may present as metastatic disease without a known primary site but, most commonly originates in the sun-exposed skin of the head, neck, and extremities. We present a 66-year-old male treated with chemo-radiation for T3N2cM0 laryngeal squamous cell carcinoma (SCCa) six years before he was diagnosed with MCC isolated to the radiated laryngopharynx. Mucosal MCC is rare and radiation-induced MCC has been hypothesized to occur in previously radiated tissue but, never before to the laryngopharynx. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.03.005DOI Listing
March 2019
1 Read

Immune Modulation in HLA-G Expressing Head and Neck Squamous Cell Carcinoma in Relation to Human Papilloma Virus Positivity: A Study From Northeast India.

Front Oncol 2019 25;9:58. Epub 2019 Feb 25.

Immunology and Immunogenetics Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India.

Tumor specific ectopic expression of the immunomodulatory molecule, HLA-G is known to mediate immune tolerance and promote carcinogenesis. Viruses too employ strategies to evade immune surveillance. Considering the role of both HLA-G and HPV in tumor growth and progression, it is pertinent to investigate the relationship between HLA-G and HPV in context of immune modulation in HNSCC. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00058/
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http://dx.doi.org/10.3389/fonc.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397850PMC
February 2019
5 Reads

Self-Assembled STrap for Global Proteomics and Salivary Biomarker Discovery.

J Proteome Res 2019 Apr 21;18(4):1907-1915. Epub 2019 Mar 21.

J. Craig Venter Institute , 9605 Medical Center Drive , Rockville , Maryland 20850 , United States.

Clinical biomarkers identified by shotgun proteomics require proteins in body fluids or tissues to be enzymatically digested before being separated and sequenced by liquid chromatography-tandem mass spectrometry. How well peptide signals can be resolved and detected is largely dependent on the quality of sample preparation. Conventional approaches such as in-gel, in-solution, and filter-based digestion, despite their extensive implementation by the community, become less appealing due to their unsatisfying protein/peptide recovery rate, lengthy sample processing, and/or lowcost-effectiveness. Read More

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http://pubs.acs.org/doi/10.1021/acs.jproteome.9b00037
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http://dx.doi.org/10.1021/acs.jproteome.9b00037DOI Listing
April 2019
9 Reads
4.245 Impact Factor

Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell carcinoma cells by high-affinity natural killer cells.

Oral Oncol 2019 Mar 1;90:38-44. Epub 2019 Feb 1.

Translational Tumor Immunology Program, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

High affinity natural killer cells (haNKs) are a cell therapy product capable of mediating both direct and antibody-dependent cell-mediated cytotoxicity (ADCC). These cells may be particularly useful in tumors that escape T-cell anti-tumor immunity by harboring antigen processing and presentation defects. Here, we demonstrated that haNKs directly kill both HPV-positive and negative head and neck squamous cell carcinoma cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193002
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http://dx.doi.org/10.1016/j.oraloncology.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410731PMC
March 2019
8 Reads
3.607 Impact Factor

The emergence of long-term survivors in recurrent and metastatic squamous cell head and neck cancer.

Curr Opin Oncol 2019 May;31(3):160-168

Medical Oncology Department, Catalan Institute of Oncology (ICO), B-ARGO Group, Barcelona, Spain.

Purpose Of Review: The systemic therapies available in recurrent and metastatic head and neck squamous cell carcinoma to date are palliative-intent treatments in most cases. However, a small subgroup of patients derives unconventional benefit and become long-term survivors, achieving cure in some cases. This review focusses on this group of patients, discusses recent literature and suggests plausible molecular hypothesis. Read More

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http://Insights.ovid.com/crossref?an=00001622-900000000-9920
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http://dx.doi.org/10.1097/CCO.0000000000000530DOI Listing
May 2019
3 Reads

A Proposal to Revise the Histopathologic Grading System of Early Oral Tongue Cancer Incorporating Tumor Budding.

Am J Surg Pathol 2019 May;43(5):703-709

Pathology.

The World Health Organization (WHO) grading system has a low prognostic value for early-stage oral tongue squamous cell carcinoma; greater prognostic power has been shown with tumor budding analysis. In this study, we combined tumor budding analysis with histopathologic grading according to WHO 2017. In our proposal, a revised grade I tumor is defined as a "well differentiated cohesive tumor"; revised grade II as a "moderately differentiated and/or slightly dissociated tumor"; and revised grade III as a "poorly differentiated and/or dissociated tumor. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001241DOI Listing
May 2019
6 Reads

Wounds Inhibit Tumor Growth In Vivo.

Ann Surg 2019 Feb 27. Epub 2019 Feb 27.

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA.

Objective: The aim of this study was to determine the interaction of full thickness excisional wounds and tumors in vivo.

Summary Of Background Data: Tumors have been described as wounds that do not heal due to similarities in stromal composition. On the basis of observations of slowed tumor growth after ulceration, we hypothesized that full thickness excisional wounds would inhibit tumor progression in vivo. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003255DOI Listing
February 2019
13 Reads

Nicotinic acetylcholine receptor gene polymorphism is not associated with tobacco-related oral squamous cell carcinoma.

Indian J Cancer 2018 Oct-Dec;55(4):399-403

Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India.

Background: Nicotinic acetylcholine receptor is implicated in carcinogenesis indirectly through increasing nicotine dependence and directly through its impact on cell-cycle regulation. Functional polymorphism in nicotinic acetylcholine receptor alpha-5 subunit gene (CHRNA5 c.1192G>A; rs16969968) is associated with nicotine dependence and risk of lung cancer. Read More

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http://dx.doi.org/10.4103/ijc.IJC_325_18DOI Listing

Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma.

Head Neck 2019 Mar 4. Epub 2019 Mar 4.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC).

Methods: In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection.

Results: SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0. Read More

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http://dx.doi.org/10.1002/hed.25733DOI Listing
March 2019
4 Reads

Enhanced antiproliferative effect of resveratrol in head and neck squamous cell carcinoma using GE11 peptide conjugated liposome.

Int J Mol Med 2019 Apr 13;43(4):1635-1642. Epub 2019 Feb 13.

Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University‑Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 510852, P.R. China.

The present study describes the preparation of a dodecapeptide YHWYGYTPQNVI (GE11)‑conjugated liposome bound with polyethylene glycol to enhance the therapeutic effect of resveratrol (RSV) in head and neck cancer cells. The results indicated that (RSV)‑loaded GE11‑conjugated liposomes (RSV‑GL) exhibited a high entrapment efficiency of >95%, with an active drug loading level of 19.5% w/w. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414163PMC
April 2019
3 Reads

Establishment and characterization of novel human oral squamous cell carcinoma cell lines from advanced‑stage tumors of buccal mucosa.

Oncol Rep 2019 Apr 7;41(4):2289-2298. Epub 2019 Feb 7.

Stem Cell Biology Group, Waghmare Lab, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai 410210, India.

Oral squamous cell carcinoma (OSCC) is a leading cause of mortality in India owing to the high percentage of tobacco chewers, smokers and alcohol consumption. OSCC is highly heterogeneous in nature; therefore poses a challenge in the treatment of the patient. To better understand the heterogeneity of the tumors, an in vitro cell line model is required. Read More

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http://dx.doi.org/10.3892/or.2019.7003DOI Listing

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana.

Health Sci Rep 2019 Feb 10;2(2):e108. Epub 2019 Jan 10.

Department of Internal Medicine, Rogel Cancer Center Michigan Medicine Ann Arbor Michigan USA.

Background And Aims: Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of increasing incidence of CSCC in Africa, and despite relatively stable levels of ultraviolet (UV) exposure, there is an observed 12 times greater risk of developing CSCC when individuals are infected with HIV. Read More

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http://dx.doi.org/10.1002/hsr2.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375545PMC
February 2019
4 Reads

High expression of MLANA in the plasma of patients with head and neck squamous cell carcinoma as a predictor of tumor progression.

Head Neck 2019 May 25;41(5):1199-1205. Epub 2019 Feb 25.

Cancer Therapeutics Research Laboratory, National Cancer Centre, Singapore.

Background: There is a paucity of plasma-based biomarkers that predict outcome in patients with head and neck squamous cell carcinoma (HNSCC) treated with chemoradiation therapy (CRT). Here, we evaluate the prognostic potential of plasma Melanoma-Antigen Recognized by T-cells 1 (MLANA) in this setting.

Methods: MLANA expression in HNSCC lines were evaluated by reverse transcription polymerase chain reaction, whereas plasma levels were quantified using ELISA in 48 patients with locally advanced HNSCC undergoing a phase 2 trial with CRT. Read More

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http://dx.doi.org/10.1002/hed.25510DOI Listing
May 2019
1 Read

Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis.

J Exp Clin Cancer Res 2019 Feb 18;38(1):84. Epub 2019 Feb 18.

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Background: A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies worldwide associated with poor overall survival in late-stage patients. HDAC inhibitors have great potential to treat this devastating disease; however, few has been studied regarding the beneficial role of HDAC inhibition in anti-HNSCC therapy and the underlying molecular mechanisms remain elusive. Read More

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http://dx.doi.org/10.1186/s13046-019-1080-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379952PMC
February 2019
1 Read

Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients with Head and Neck Cancer: Results of the Biology-Driven Phase Ii Clinical Trial Pravacur.

Int J Radiat Oncol Biol Phys 2019 Feb 15. Epub 2019 Feb 15.

Radiation Oncology Department, CHUV Lausanne, Switzerland.

Purpose: The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.

Methods And Materials: The main inclusion criteria were: patients with HNSCC in remission, with grade ≥2 cutaneous and subcutaneous neck RIF (NCI-CTCAE v4.0); no current treatment with statins or fibrates. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.024DOI Listing
February 2019
7 Reads

analysis reveals a shared immune signature in -mutated carcinomas with varying correlations to prognosis.

PeerJ 2019 11;7:e6402. Epub 2019 Feb 11.

DeepSeeq Bioinformatics, Bangalore, Karnataka, India.

Background: Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing populations, revealed that ∼34% of the affected patients harbor mutations in the gene Uterine Corpus Endometrial Carcinoma (UCEC) is another cancer where ∼10% cases harbor mutations. Caspase-8, the protease encoded by gene, plays a dual role in programmed cell death, which in turn has an important role in tumor cell death and drug resistance. Read More

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http://dx.doi.org/10.7717/peerj.6402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375258PMC
February 2019
1 Read

Successful treatment with trastuzumab in HER2-positive squamous cell carcinoma of the head and neck.

Oral Oncol 2019 Apr 14;91:129-131. Epub 2019 Feb 14.

Department of Head and Neck Cancer, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.008DOI Listing

PDK1 Mediates -Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including , but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR inhibitors and lacks validated biomarkers of response. We tested the hypothesis that an unbiased pharmacogenomics approach to PI3K/mTOR pathway inhibitors would identify novel, clinically relevant molecular vulnerabilities in HNSCC with loss of tumor suppressor function. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3276DOI Listing
February 2019
9 Reads
8.722 Impact Factor

[Progress in roles and mechanisms of deacetylase SIRT7].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):13-26

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. Read More

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http://dx.doi.org/10.13345/j.cjb.180139DOI Listing
January 2019
2 Reads

Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.

Trends Cancer 2019 Feb 21;5(2):82-84. Epub 2018 Dec 21.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures. We suggest that these unique isoforms play a role in the pathogenesis of HNSCC. Read More

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http://dx.doi.org/10.1016/j.trecan.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404231PMC
February 2019

HPV as a marker for molecular characterization in head and neck oncology: Looking for a standardization of clinical use and of detection method(s) in clinical practice.

Head Neck 2019 Apr 12;41(4):1104-1111. Epub 2019 Feb 12.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. Read More

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http://dx.doi.org/10.1002/hed.25591DOI Listing
April 2019
7 Reads

The microRNA-375 as a potentially promising biomarker to predict the prognosis of patients with head and neck or esophageal squamous cell carcinoma: a meta-analysis.

Eur Arch Otorhinolaryngol 2019 Apr 12;276(4):957-968. Epub 2019 Feb 12.

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Background: The prognostic value of microRNA-375 (miR-375) expression in squamous cell carcinoma (SCC) had been reported in the previous studies; however, the results remain inconsistent. This study was performed to investigate the prognostic significance of miR-375 expression in SCC based on all eligible evidences.

Methods: Relevant studies were identified by searching PubMed, Embace, Medline, Cochrane Library, and China Biology Medicine disk. Read More

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http://dx.doi.org/10.1007/s00405-019-05325-8DOI Listing
April 2019
1 Read

Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019