2,025 results match your criteria Cell Biology of Head and Neck Squamous Cell Carcinoma


Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis.

J Exp Clin Cancer Res 2019 Feb 18;38(1):84. Epub 2019 Feb 18.

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Background: A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies worldwide associated with poor overall survival in late-stage patients. HDAC inhibitors have great potential to treat this devastating disease; however, few has been studied regarding the beneficial role of HDAC inhibition in anti-HNSCC therapy and the underlying molecular mechanisms remain elusive. Read More

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http://dx.doi.org/10.1186/s13046-019-1080-8DOI Listing
February 2019

Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients with Head and Neck Cancer: Results of the Biology-Driven Phase Ii Clinical Trial Pravacur.

Int J Radiat Oncol Biol Phys 2019 Feb 15. Epub 2019 Feb 15.

Radiation Oncology Department, CHUV Lausanne, Switzerland.

Purpose: The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.

Methods And Materials: The main inclusion criteria were: patients with HNSCC in remission, with grade ≥2 cutaneous and subcutaneous neck RIF (NCI-CTCAE v4.0); no current treatment with statins or fibrates. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.024DOI Listing
February 2019

analysis reveals a shared immune signature in -mutated carcinomas with varying correlations to prognosis.

PeerJ 2019 11;7:e6402. Epub 2019 Feb 11.

DeepSeeq Bioinformatics, Bangalore, Karnataka, India.

Background: Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing populations, revealed that ∼34% of the affected patients harbor mutations in the gene Uterine Corpus Endometrial Carcinoma (UCEC) is another cancer where ∼10% cases harbor mutations. Caspase-8, the protease encoded by gene, plays a dual role in programmed cell death, which in turn has an important role in tumor cell death and drug resistance. Read More

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http://dx.doi.org/10.7717/peerj.6402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375258PMC
February 2019

Successful treatment with trastuzumab in HER2-positive squamous cell carcinoma of the head and neck.

Oral Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Head and Neck Cancer, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.008DOI Listing
February 2019

PDK1 mediates NOTCH1-mutated head and neck squamous carcinoma vulnerability to therapeutic PI3K/mTOR inhibition.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center

Purpose: Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including NOTCH1, but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR inhibitors and lacks validated biomarkers of response. We tested the hypothesis that an unbiased pharmacogenomics approach to PI3K/mTOR pathway inhibitors would identify novel, clinically relevant molecular vulnerabilities in HNSCC with loss of tumor suppressor function. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3276DOI Listing
February 2019
2 Reads

[Progress in roles and mechanisms of deacetylase SIRT7].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):13-26

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. Read More

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http://dx.doi.org/10.13345/j.cjb.180139DOI Listing
January 2019
1 Read

Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck.

Clin Cancer Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine

Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora A kinase (AURKA) is overexpressed and an oncogenic driver, its inhibition has only modest clinical effects in HPV-negative HNSCC. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0440DOI Listing
February 2019
2 Reads
8.722 Impact Factor

Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.

Trends Cancer 2019 Feb 21;5(2):82-84. Epub 2018 Dec 21.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures. We suggest that these unique isoforms play a role in the pathogenesis of HNSCC. Read More

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http://dx.doi.org/10.1016/j.trecan.2018.12.001DOI Listing
February 2019

HPV as a marker for molecular characterization in head and neck oncology: Looking for a standardization of clinical use and of detection method(s) in clinical practice.

Head Neck 2019 Feb 12. Epub 2019 Feb 12.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. Read More

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http://dx.doi.org/10.1002/hed.25591DOI Listing
February 2019
1 Read

The microRNA-375 as a potentially promising biomarker to predict the prognosis of patients with head and neck or esophageal squamous cell carcinoma: a meta-analysis.

Eur Arch Otorhinolaryngol 2019 Feb 12. Epub 2019 Feb 12.

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Background: The prognostic value of microRNA-375 (miR-375) expression in squamous cell carcinoma (SCC) had been reported in the previous studies; however, the results remain inconsistent. This study was performed to investigate the prognostic significance of miR-375 expression in SCC based on all eligible evidences.

Methods: Relevant studies were identified by searching PubMed, Embace, Medline, Cochrane Library, and China Biology Medicine disk. Read More

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http://dx.doi.org/10.1007/s00405-019-05325-8DOI Listing
February 2019

Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019

Frequent Alteration of Annexin A9 and A10 in HPV-Negative Head and Neck Squamous Cell Carcinomas: Correlation with the Histopathological Differentiation Grade.

J Clin Med 2019 Feb 10;8(2). Epub 2019 Feb 10.

Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, University of Oviedo, Avda. Roma, 33011, Oviedo, Spain.

The annexin protein superfamily has been implicated in multiple physiological and pathological processes, including carcinogenesis. Altered expression of various annexins has frequently been observed and linked to the development and progression of various human malignancies. However, information is lacking on the expression and clinical significance of annexin A9 (ANXA9) and A10 (ANXA10) in head and neck squamous cell carcinomas (HNSCC). Read More

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http://dx.doi.org/10.3390/jcm8020229DOI Listing
February 2019

Oncoproteomic and gene expression analyses identify prognostic biomarkers for second primary malignancy in patients with head and neck squamous cell carcinoma.

Mod Pathol 2019 Feb 8. Epub 2019 Feb 8.

Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Patients with head and neck squamous cell carcinoma are at increased risk of developing a second primary malignancy, which is associated with poor prognosis and early death. To help improve clinical outcome, we aimed to identify biomarkers for second primary malignancy risk prediction using the routinely obtained formalin-fixed paraffin-embedded tissues of the index head and neck cancer. Liquid chromatography-tandem mass spectrometry was initially performed for candidate biomarker discovery in 16 pairs of primary cancer tissues and their matched normal mucosal epithelia from head and neck squamous cell carcinoma patients with or without second primary malignancy. Read More

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http://dx.doi.org/10.1038/s41379-019-0211-2DOI Listing
February 2019
6.187 Impact Factor

Expression of immune-regulatory molecules in circulating tumor cells derived from patients with head and neck squamous cell carcinoma.

Oral Oncol 2019 Feb 17;89:34-39. Epub 2018 Dec 17.

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Objectives: Circulating tumor cells (CTCs) are cells that have shed from tumor tissue into the bloodstream, and the detection and characterization of CTCs in head and neck squamous cell carcinoma (HNSCC) still remain a challenge.

Materials And Methods: CTCs were isolated from 30 patients with HNSCC with recurrent and/or distant metastasis, via the depletion of CD45-positive cells with magnetic beads and the expression of multiple epithelial markers (CK19, EpCAM, EGFR, and c-Met) was analyzed by RT-qPCR with a low concentration of RNA from the CTC population. We next investigated the expression of the immune-regulatory molecules, PD-L1, PD-L2, and CD47, in CTC-positive patients and the PD-L1 expression in CTCs was compared with that in tumor tissues. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.12.002DOI Listing
February 2019
5 Reads

Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells.

Front Oncol 2019 23;9:13. Epub 2019 Jan 23.

Division of Head and Neck Oncologic and Microvascular Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA, United States.

Epidermal growth factor receptor (EGFR) inhibitors have limited efficacy in head and neck squamous cell carcinoma (HNSCC) due to various resistance mechanisms, such as activation of the insulin-like growth factor-1 receptor (IGF1R), which initiates pro-survival signaling. Survivin, a member of the inhibitor of apoptosis proteins family, is expressed at relatively high levels in malignant tissues and plays a role in cell division. Expression of survivin in tumors has been shown to correlate with poor prognosis due to chemotherapy resistance and anti-apoptotic behavior. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00013/
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http://dx.doi.org/10.3389/fonc.2019.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351440PMC
January 2019
6 Reads

Induction of squamous cell carcinoma after MAP3K8 overexpression in murine salivry gland epithelial cells.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Salivary gland neoplasms are relatively rare and comprise only 1%-4% of all human neoplasms. Salivary gland neoplasms also show an extremely wide range of morphological diversity. Currently, the genetic alterations and corresponding molecular mechanisms underlying salivary gland neoplasms development remain largely unknown. Read More

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http://dx.doi.org/10.1002/hed.25411DOI Listing
February 2019

Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma.

Oncoimmunology 2019 10;8(3):1535293. Epub 2019 Jan 10.

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.

B lymphocytes are important players in immune responses to cancer. However, their composition and function in head and neck squamous cell carcinoma (HNSCC) has not been well described. Here, we analyzed B cell subsets in HNSCC (n = 38), non-cancerous mucosa (n = 14) and peripheral blood from HNSCC patients (n = 38) and healthy controls (n = 20) by flow cytometry. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1535293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350680PMC
January 2019
4 Reads

Robust Cell Detection and Segmentation for Image Cytometry Reveal Th17 Cell Heterogeneity.

Cytometry A 2019 Feb 4. Epub 2019 Feb 4.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.

Image cytometry enables quantitative cell characterization with preserved tissue architecture; thus, it has been highlighted in the advancement of multiplex immunohistochemistry (IHC) and digital image analysis in the context of immune-based biomarker monitoring associated with cancer immunotherapy. However, one of the challenges in the current image cytometry methodology is a technical limitation in the segmentation of nuclei and cellular components particularly in heterogeneously stained cancer tissue images. To improve the detection and specificity of single-cell segmentation in hematoxylin-stained images (which can be utilized for recently reported 12-biomarker chromogenic sequential multiplex IHC), we adapted a segmentation algorithm previously developed for hematoxlin and eosin-stained images, where morphological features are extracted based on Gabor-filtering, followed by stacking of image pixels into n-dimensional feature space and unsupervised clustering of individual pixels. Read More

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http://dx.doi.org/10.1002/cyto.a.23726DOI Listing
February 2019

MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer.

Int J Cancer 2019 Jan 29. Epub 2019 Jan 29.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

An understanding of the mechanisms underlying acquired resistance to cetuximab is urgently needed to improve cetuximab efficacy in patients with head and neck squamous cell carcinoma (HNSCC). Here, we present a clinical observation that MET pathway activation constitutes the mechanism of acquired resistance to cetuximab in a patient with HNSCC. Specifically, RNA sequencing and mass spectrometry analysis of cetuximab-sensitive (Cetux ) and cetuximab-resistant (Cetux ) tumors indicated MET amplification and overexpression in the Cetux tumor compared to the Cetux lesion. Read More

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http://doi.wiley.com/10.1002/ijc.32170
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http://dx.doi.org/10.1002/ijc.32170DOI Listing
January 2019
4 Reads

Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for -altered head and neck cancer.

J Exp Med 2019 Feb 25;216(2):419-427. Epub 2019 Jan 25.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA

is the most commonly altered oncogene in head and neck squamous cell carcinoma (HNSCC). We evaluated the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on survival in a -characterized cohort of 266 HNSCC patients and explored the mechanism in relevant preclinical models including patient-derived xenografts. Among subjects with mutations or amplification, regular NSAID use (≥6 mo) conferred markedly prolonged disease-specific survival (DSS; hazard ratio 0. Read More

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http://www.jem.org/lookup/doi/10.1084/jem.20181936
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http://dx.doi.org/10.1084/jem.20181936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363423PMC
February 2019
25 Reads

Interest to consider re-challenging by cetuximab and platinum containing regimen in recurrent Head and Neck Cancer.

Oncotarget 2018 Dec 25;9(101):37581-37588. Epub 2018 Dec 25.

Pharmacy Department, Centre Paul Strauss, Strasbourg, France.

Background: The EXTREME protocol is the standard of care for recurrent or metastatic head and neck squamous-cell carcinoma (R/M HNSCC) in first line. Beyond the first-line except immunotherapy, poor efficacy was reported by second-line chemotherapy. Re-challenge strategies based on a repetition of the first line with platinum and cetuximab regimens might have been an option to consider. Read More

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http://dx.doi.org/10.18632/oncotarget.26506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331031PMC
December 2018
1 Read

Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus.

Int J Cancer 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology, New York University School of Medicine, New York, NY.

Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. Read More

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http://doi.wiley.com/10.1002/ijc.32152
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http://dx.doi.org/10.1002/ijc.32152DOI Listing
January 2019
3 Reads

Possible role of in orodigestive cancers.

J Oral Microbiol 2019 9;11(1):1563410. Epub 2019 Jan 9.

Department of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a significant risk factor for orodigestive carcinogenesis. is proposed as a keystone pathogen in chronic periodontitis causing both dysbiosis and discordant immune response. Read More

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http://dx.doi.org/10.1080/20002297.2018.1563410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327928PMC
January 2019
1 Read

The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.

Clin Cancer Res 2019 Jan 22. Epub 2019 Jan 22.

Medical faculty, OncoRay, TU Dresden

Purpose: The heavy chain of the CD98 protein (CD98hc) is encoded by the SLC3A2 gene. Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High SLC3A2 mRNA expression levels are associated with poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiochemotherapy. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2951DOI Listing
January 2019

p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer.

Oncogene 2019 Jan 21. Epub 2019 Jan 21.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradiation showed decreased oxygen consumption and increased glycolysis with compromised mitochondria, corresponding with their enhanced sensitivity to drugs that target glycolysis. Read More

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http://dx.doi.org/10.1038/s41388-019-0697-6DOI Listing
January 2019
2 Reads

Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma.

Anal Chim Acta 2019 Mar 2;1050:113-122. Epub 2018 Nov 2.

Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Oral cavity squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, is associated with poor prognosis and high mortality worldwide. Moreover, knowledge of the metabolic alterations that occur in OSCC is still limited. In the present study, we used a quantitative metabolomic approach with chemical isotope labeling (CIL) to analyze alterations in the metabolite levels in paired cancerous (T) and adjacent noncancerous (AN) tissues from 31 OSCC patients. Read More

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http://dx.doi.org/10.1016/j.aca.2018.10.070DOI Listing
March 2019
1 Read

Down-regulation of mitochondrial NADH and cytochrome b gene associated with high tumor stages in head and neck squamous cell carcinoma.

Arch Oral Biol 2019 Jan 10;99:107-112. Epub 2019 Jan 10.

Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. Electronic address:

Objective: This study aimed to determine mitochondrial mRNA expression levels and the relationships between these expression levels and various adverse clinicopathological characteristics.

Methods: The mRNA expression levels of all 12 genes encoded protein, located on the heavy-strand of mitochondrial DNA including cytochrome b, NADH1, NADH2, NADH3, NADH4, NADH4L, NADH5, ATPase6, ATPase8, cytochrome c oxidase subunit 1, cytochrome c oxidase subunit 2, cytochrome c oxidase subunit 3 were analyzed in 30 head and neck squamous cell carcinoma (HNSCC) and the corresponding normal tissues using reverse transcriptase quantitative real time PCR. Pearson Chi-square test was used to determine the relationships between these expression levels and categorical parameters. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183050
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http://dx.doi.org/10.1016/j.archoralbio.2019.01.005DOI Listing
January 2019
5 Reads

Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments.

Oncogene 2019 Jan 17. Epub 2019 Jan 17.

Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.

Although head and neck squamous cell carcinoma (HNSCC) has in the past been largely associated with tobacco use, human papillomavirus (HPV+) oropharynx cancer has in recent years emerged as the fastest growing type of HNSCC. Patients with HPV+ HNSCC have a better prognosis; however, the 5-year survival for both HPV+ and HPV- subtypes with recurrent or metastatic disease is poor. To gain insights into the tumor microenvironments of both HNSCC subtypes and identify potential therapeutic targets, we performed epigenomic deconvolution on 580 HNSCC samples from the TCGA dataset. Read More

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http://dx.doi.org/10.1038/s41388-018-0659-4DOI Listing
January 2019

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer.

Cancer Cell Int 2019 14;19:16. Epub 2019 Jan 14.

1Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers and new targets for treatment in clinically relevant in vitro tumor models is essential. Five HNSCC-derived cell lines were used to assess the effect of 3D culturing compared to 2D monolayers in terms of cell proliferation, response to anti-cancer therapy as well as expression of EMT and CSC genes. Read More

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http://dx.doi.org/10.1186/s12935-019-0733-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332598PMC
January 2019
1 Read

APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma.

Oncogene 2019 Jan 15. Epub 2019 Jan 15.

Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.

Recent studies have revealed the mutational signatures underlying the somatic evolution of cancer, and the prevalences of associated somatic genetic variants. Here we estimate the intensity of positive selection that drives mutations to high frequency in tumors, yielding higher prevalences than expected on the basis of mutation and neutral drift alone. We apply this approach to a sample of 525 head and neck squamous cell carcinoma exomes, producing a rank-ordered list of gene variants by selection intensity. Read More

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http://www.nature.com/articles/s41388-018-0657-6
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http://dx.doi.org/10.1038/s41388-018-0657-6DOI Listing
January 2019
4 Reads
8.459 Impact Factor

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy.

J Immunother Cancer 2019 Jan 15;7(1):10. Epub 2019 Jan 15.

Department of Otolaryngology-Head and Neck surgery, Baylor College of Medicine, Houston, TX, USA.

Background: Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there is generation of an anti-tumoral immune response. However, CRT has also been shown to promote immunosuppressive mechanisms which must be blocked or reversed to maximize its immune stimulating effects.

Methods: Therefore, using a preclinical model of human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC), we developed a clinically relevant therapy combining CRT and two existing immunomodulatory drugs: cyclophosphamide (CTX) and the small molecule inducible nitric oxide synthase (iNOS) inhibitor L-n6-(1-iminoethyl)-lysine (L-NIL). Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0485-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332704PMC
January 2019
7 Reads

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses.

BMC Cancer 2019 Jan 14;19(1):64. Epub 2019 Jan 14.

Department of Radiation Oncology, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan.

Background: Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular signature associated with radio-resistance in HNC for further clinical applications.

Methods: Affymetrix cDNA microarrays were used to globally survey different transcriptomes between HNC cell lines and isogenic radioresistant sublines. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5243-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332600PMC
January 2019
6 Reads
3.362 Impact Factor

Involvement of HPV Infection in the Release of Macrophage Migration Inhibitory Factor in Head and Neck Squamous Cell Carcinoma.

J Clin Med 2019 Jan 10;8(1). Epub 2019 Jan 10.

Department of Human Anatomy and Experimental Oncology, Université de Mons (UMons), Research Institute for Health Sciences and Technology, 7000 Mons, Belgium.

Human papilloma virus (HPV) infection has been well-established as a risk factor in head and neck squamous cell carcinoma (HNSCC). The carcinogenic effect of HPV is mainly due to the E6 and E7 oncoproteins, which inhibit the functions of p53 and pRB, respectively. These oncoproteins could also play a role in the Warburg effect, thus favoring tumor immune escape. Read More

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http://www.mdpi.com/2077-0383/8/1/75
Publisher Site
http://dx.doi.org/10.3390/jcm8010075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352225PMC
January 2019
8 Reads

Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer.

Biomed Res Int 2018 6;2018:1972606. Epub 2018 Dec 6.

Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Accumulating evidences demonstrated that microRNA-target gene pairs were closely related to tumorigenesis and development. However, the correlation between miRNA and target gene was insufficiently understood, especially its changes between tumor and normal tissues.

Objectives: The aim of this study was to evaluate the changes of correlation of miRNAs-target pairs between normal and tumor. Read More

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http://dx.doi.org/10.1155/2018/1972606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304515PMC
December 2018
2 Reads

Variations in HPV function are associated with survival in squamous cell carcinoma.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Department of Head and Neck Surgery and.

Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing dramatically. Although long-term survival rates for these patients are high, they often suffer from permanent radiotherapy-related morbidity. This has prompted the development of de-escalation clinical protocols to reduce morbidity. Read More

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https://insight.jci.org/articles/view/124762
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http://dx.doi.org/10.1172/jci.insight.124762DOI Listing
January 2019
15 Reads

Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells.

Int J Mol Sci 2019 Jan 8;20(1). Epub 2019 Jan 8.

The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

Combination radiation and chemotherapy are commonly used to treat locoregionally advanced head and neck squamous cell carcinoma (HNSCC). Aggressive dosing of these therapies is significantly hampered by side effects due to normal tissue toxicity. Selenium represents an adjuvant that selectively sensitizes cancer cells to these treatments modalities, potentially by inducing lipid peroxidation (LPO). Read More

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http://dx.doi.org/10.3390/ijms20010225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337472PMC
January 2019
1 Read

Impact of HPV infection on gene expression and methylation in oral cancer patients.

J Med Microbiol 2019 Jan 9. Epub 2019 Jan 9.

1​Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Purpose: The current study aimed to examine the association between head and neck squamous cell carcinoma (HNSCC) and infection with different human papillomavirus virus (HPV) subtypes, including analysis of promoter methylation of several genes (APC, CDKN2A, MGMT, CDH1 and TIMP3) and the correlation with their mRNA expression in tumours and surgical margins.

Methodology: In 47 patients with a primary tumour of the oral cavity, HPV detection and identification of 33 subtypes was performed after previous DNA isolation using a GenoFlow HPV Array Test Kit.

Results: Fifteen patients (31. Read More

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http://www.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.000898DOI Listing
January 2019
7 Reads

IMRT-based treatment of unknown primary malignancy of the head and neck: Outcomes and improved toxicity with decreased mucosal dose and larynx sparing.

Head Neck 2019 Jan 8. Epub 2019 Jan 8.

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, Massachusetts.

Background: Radiation therapy for squamous cell cancer of the head and neck with unknown primary (head and neck CUP) has been associated with significant levels of swallowing toxicity. We examined the effect of changes in mucosal dose on development of laryngeal strictures and percutaneous endoscopic gastrostomy (PEG) dependence.

Methods: Retrospective analysis of 58 patients with head and neck CUP treated with intensity-modulated radiation therapy (IMRT) at the Dana Farber Cancer Institute from August 2004 through July 2013. Read More

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http://doi.wiley.com/10.1002/hed.25531
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http://dx.doi.org/10.1002/hed.25531DOI Listing
January 2019
7 Reads

Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.

Oral Oncol 2019 Jan 30;88:145-152. Epub 2018 Nov 30.

Institute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address:

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.020DOI Listing
January 2019
1 Read

Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations.

Neoplasia 2019 02 4;21(2):197-205. Epub 2019 Jan 4.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR; Precision Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

Smoking and alcohol intake are major risk factors in head and neck squamous cell carcinomas (HNSCCs). Although the link between TP53 mutation and smoking has been well established, very little is known about the link between acquired uniparental disomy (aUPD) and smoking and/or alcohol consumption or other clinical characteristics. We used TCGA genomic data to investigate whether smoking, alcohol intake, clinical and demographic variables, HPV status and TP53 mutation are associated with aUPD at specific chromosomal regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183060
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http://dx.doi.org/10.1016/j.neo.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321975PMC
February 2019
1 Read

Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.

Authors:
M V Bais

J Dent Res 2019 Mar 7;98(3):268-276. Epub 2019 Jan 7.

1 Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

The most common type of head and neck cancer, head and neck squamous cell carcinoma (HNSCC), can develop therapeutic resistance that complicates its treatment. The 5-y survival rate for HNSCC remains at ~50%, and improving these outcomes requires a better understanding of the pathogenesis of HNSCC. Studies of HNSCC using in vitro, ex vivo, and in vivo approaches provide a novel conceptual framework based on epigenetic mechanisms for developing future clinical applications. Read More

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http://dx.doi.org/10.1177/0022034518816947DOI Listing
March 2019
2 Reads

Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity.

J Natl Cancer Inst 2019 Jan 5. Epub 2019 Jan 5.

Department of Biochemistry and Molecular Biology.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer, with high morbidity and mortality. Racial disparity in HNSCC is observed between African Americans (AAs) and whites, effecting both overall and 5-year survival, with worse prognosis for AAs. In addition to socio-economic status and demographic factors, many epidemiological studies have also identified factors including coexisting human papillomavirus (HPV) infection, primary tumor location, and a variety of somatic mutations that contribute to the prognostic incongruities in HNSCC patients among AAs and whites. Read More

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http://dx.doi.org/10.1093/jnci/djy207DOI Listing
January 2019
5 Reads

Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function and Tumor Cell Invasion.

Mol Cancer Res 2019 Jan 4. Epub 2019 Jan 4.

Biochemistry/WVUCI, West Virginia University School of Medicine

Malregulation of the actin cytoskeleton enhances tumor cell motility and invasion. The actin-binding protein cortactin facilitates branched actin network formation through activation of the actin-related protein (Arp) 2/3 complex. Increased cortactin expression due to gene amplification is observed in head and neck squamous cell carcinoma (HNSCC) and other cancers, corresponding with elevated tumor progression and poor patient outcome. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0391DOI Listing
January 2019

Targeted inactivation of EPS8 using dendrimer-mediated delivery of RNA interference.

Int J Pharm 2019 Feb 28;557:178-181. Epub 2018 Dec 28.

Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, United States; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States. Electronic address:

We developed polyamidoamine dendrimers conjugated with epidermal growth factor (EGF) for use in receptor-mediated delivery of therapeutics to cancer cells. Here, we demonstrate the utility of this approach to inhibit proliferation and migration of head and neck squamous carcinoma cells through targeting of EPS8, a key regulator of squamous carcinoma growth and motility. Use of EGF-dendrimers to deliver siRNA or shRNA against EPS8 resulted in inhibition of cell growth and reduction in cell motility. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.060DOI Listing
February 2019

Expression profile analysis identifies a two-gene signature for prediction of head and neck squamous cell carcinoma patient survival.

J Cancer Res Ther 2018 ;14(7):1525-1534

Department of Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, China.

Aim: The aim of this study is to identify a gene prognostic signature for the head-and-neck squamous cell carcinoma (HNSCC). HNSCC is one of the most common malignancies worldwide; however, the molecular mechanisms underlying the malignancy are unclear.

Materials And Methods: We analyzed the gene expression profiles of GSE2379, GSE53819, and GSE59102 derived from the gene expression omnibus, and the cancer genome atlas (TCGA) HNSC databases. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_557_18DOI Listing
February 2019
10 Reads

Is there any association between green tea consumption and the risk of head and neck squamous cell carcinoma: Finding from a case-control study.

Arch Oral Biol 2019 Feb 7;98:280-284. Epub 2018 Dec 7.

Assistant professor of Surgery Oncology, Department of Surgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Green tea consumption has been shown to reduce the incidence of head and neck squamous cell carcinoma (HNSCC) in experimental animal models, however the results from human studies are inconclusive. The aim of this study was to evaluate the relationship between green tea consumption and the risk of HNSCC.

Design: The study utilised a standardised questionnaire to investigate the relationship between green tea consumption and HNSCC experience. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2018.12.003DOI Listing
February 2019
3 Reads

Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma.

Head Neck 2018 Dec 23. Epub 2018 Dec 23.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.

Background: Head and neck squamous cell carcinoma (HNSCC) is more prevalent in men than women and this disparity cannot be fully explained by known risk factors. Recent studies have shown that loss of Y chromosome (LoY) confers an increased risk of solid cancer and reduces life expectancy in men.

Methods: Using publicly available data from The Cancer Genome Atlas, we investigated the prevalence of LoY and its association with clinicopathological features in male HNSCC. Read More

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http://dx.doi.org/10.1002/hed.25537DOI Listing
December 2018
1 Read

Factors affecting prognosis in locoregional recurrence of oral squamous cell carcinoma.

J Oral Pathol Med 2018 Dec 21. Epub 2018 Dec 21.

Institute of Head and Neck Studies and Education, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Background: Recurrence of oral squamous cell carcinoma (rOSCC) after primary treatment is associated with poor survival outcomes. Salvage treatment with further surgery, radiotherapy and chemotherapy has high morbidity, making patient selection crucial. However, in the recurrence setting, reliable stratification data are scarce. Read More

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http://dx.doi.org/10.1111/jop.12815DOI Listing
December 2018

Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis.

Head Neck 2018 Dec 21. Epub 2018 Dec 21.

Humanitas Clinical and Research Center, Rozzano (MI).

Background: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.

Methods: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy. Read More

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http://dx.doi.org/10.1002/hed.25522DOI Listing
December 2018

Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas.

Mol Carcinog 2018 Dec 21. Epub 2018 Dec 21.

Department of Pathology, School of Medicine, Molecular Biology Program, Medical Scientist Training Program, University of Colorado, Aurora, Colorado.

Reports regarding the frequency of SMAD4 loss in human head and neck squamous cell carcinoma (HNSCC) vary significantly. We have shown that SMAD4 deletion contributes to HNSCC initiation and progression. Therefore, accurately detecting genetic SMAD4 loss is critical to determine prognosis and therapeutic interventions in personalized medicine. Read More

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http://dx.doi.org/10.1002/mc.22958DOI Listing
December 2018
3 Reads
4.808 Impact Factor