2,459 results match your criteria Cell Biology of Head and Neck Squamous Cell Carcinoma


A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

J Pathol 2020 Jul 3. Epub 2020 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, US.

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with squamous cell carcinomas display hyperactive NRF2 signaling, harboring activating mutations and copy number amplifications of the NFE2L2 oncogene or inactivating mutations or deletions of KEAP1 or CUL3, the proteins of which co-complex to ubiquitylate and degrade NRF2 protein. Read More

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http://dx.doi.org/10.1002/path.5504DOI Listing

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.

Expert Rev Mol Med 2020 Jul 2;22:e3. Epub 2020 Jul 2.

Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 200 London Road, LiverpoolL3 9TA, UK.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with reported incidences of ~800 000 cases each year. One of the critical determinants in patient response to radiotherapy, particularly for oropharyngeal cancers, is human papillomavirus (HPV) status where HPV-positive patients display improved survival rates and outcomes particularly because of increased responsiveness to radiotherapy. The increased radiosensitivity of HPV-positive HNSCC has been largely linked with defects in the signalling and repair of DNA double-strand breaks. Read More

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http://dx.doi.org/10.1017/erm.2020.4DOI Listing

Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts.

Cancers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Oral cavity squamous cell carcinomas (OSCCs) are aggressive tumors, and their recurrence leads to poor prognosis and reduced survival rates. This study aimed to identify therapeutic targets and to evaluate the efficacy of targeted inhibitors in OSCC patient-derived xenograft (PDX) models. Herein, we reported that OSCC PDXs recapitulated the genomic signatures of their paired primary tumors and the expression of , , and was significantly upregulated in OSCC. Read More

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http://dx.doi.org/10.3390/cancers12071726DOI Listing

Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.

Mol Cancer Ther 2020 Jun 30. Epub 2020 Jun 30.

Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma with a proclivity for systemic dissemination, leading many patients to present with advanced-stage disease and fail available treatments. There is a notable lack of targeted therapies for NPC, despite working knowledge of multiple proteins with integral roles in NPC cancer biology. These proteins include EZH2, Snail, eIF4E, and IMPDH, which are all overexpressed in NPC and correlated with poor prognosis. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0572DOI Listing

Index of Cancer-Associated Fibroblasts Is Superior to the Epithelial-Mesenchymal Transition Score in Prognosis Prediction.

Cancers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan.

In many solid tumors, tissue of the mesenchymal subtype is frequently associated with epithelial-mesenchymal transition (EMT), strong stromal infiltration, and poor prognosis. Emerging evidence from tumor ecosystem studies has revealed that the two main components of tumor stroma, namely, infiltrated immune cells and cancer-associated fibroblasts (CAFs), also express certain typical EMT genes and are not distinguishable from intrinsic tumor EMT, where bulk tissue is concerned. Transcriptomic analysis of xenograft tissues provides a unique advantage in dissecting genes of tumor (human) or stroma (murine) origins. Read More

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http://dx.doi.org/10.3390/cancers12071718DOI Listing

Glycoprotein Nonmetastatic Melanoma Protein B as Potential Imaging Marker in Posttherapeutic Metastatic Head and Neck Cancer.

Otolaryngol Head Neck Surg 2020 Jun 30:194599820932869. Epub 2020 Jun 30.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Objective: To evaluate expression of potential molecular imaging targets epidermal growth factor receptor (EGFR), glycoprotein nonmetastatic melanoma protein B (GPNMB), and vascular endothelial growth factor (VEGF) in lymph nodes (LNs) with or without head and neck squamous cell carcinoma (HNSCC) metastases after (chemo)radiation.

Study Design: Retrospective study comparing receptor expression in paired lymph nodes after initial treatment.

Setting: A tertiary referral hospital. Read More

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http://dx.doi.org/10.1177/0194599820932869DOI Listing

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

: Cisplatin (CDDP) is commonly utilized in the treatment of advanced solid tumors including head and neck squamous cell carcinoma (HNSCC). Cisplatin response remains highly variable among individual tumors and development of cisplatin resistance is common. We hypothesized that development of cisplatin resistance is partially driven by metabolic reprogramming. Read More

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http://dx.doi.org/10.3390/cancers12061670DOI Listing

Predictors of chemotherapy and its effects in early stage squamous cell carcinoma of the larynx.

Laryngoscope Investig Otolaryngol 2020 Jun 24;5(3):445-452. Epub 2019 Dec 24.

Division of Radiation Oncology Allegheny Health Network Cancer Institute, Allegheny General Hospital Pittsburgh PA.

Background: Squamous cell carcinoma (SCC) of larynx is a common head and neck cancer. For cases that are node negative, the role of definitive concurrent chemoradiation is unclear and not supported by guidelines but used at provider discretion. To address this knowledge gap, we examined the oncological outcomes with additional chemotherapy and factors correlated with the chemotherapy administration. Read More

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http://dx.doi.org/10.1002/lio2.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314463PMC

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1637-1644. Epub 2020 Jun 1.

Department of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.

Background/aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1637DOI Listing

Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival.

Sci Rep 2020 Jun 25;10(1):10382. Epub 2020 Jun 25.

Postgraduate Program in Biotechnology/RENORBIO, Federal University of Espirito Santo, Av. Marechal Campos, 1468, Vitoria, 29.040-090, ES, Brazil.

Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. Read More

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http://dx.doi.org/10.1038/s41598-020-67270-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316707PMC

Characteristics of Head and Neck Squamous Cell Carcinoma Cell Lines Reflect Human Tumor Biology Independent of Primary Etiologies and HPV Status.

Transl Oncol 2020 Jun 20;13(10):100808. Epub 2020 Jun 20.

Department of Otolaryngology-Head & Neck Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, US 48109. Electronic address:

Explanations for the differences in clinical outcomes in head and neck squamous cell carcinomas (HNSCCs) when compared by similar tumor location, stage, nodal status, human papillomavirus (HPV) status, and patient history remain elusive. Cell lines are an excellent tool of study for understanding the in vitro properties of cancers. However, HNSCC cell lines from progression-free and/or HPV-positive tumors are very rare. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317296PMC

The impact of photobiomodulation therapy on the biology and behavior of head and neck squamous cell carcinomas cell lines.

J Photochem Photobiol B 2020 Jun 3;209:111924. Epub 2020 Jun 3.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA. Electronic address:

Photobiomodulation therapy (PBMT) is an emerging therapeutic modality designed to prevent and treat chemotherapy-driven oral mucositis (OM). However, the response of tumor cells to the effects of PBMT remains poorly understood. Our study explores the effects of PBMT in head and neck squamous cell carcinoma (HNSCC) based on cellular proliferation, migration, and survival of tumor cells and its population of cancer stem cells (CSC). Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111924DOI Listing

Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2020 Jun 17;12(6). Epub 2020 Jun 17.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Body fluids of patients with head and neck squamous cell carcinoma (HNSCC) are enriched in exosomes that reflect properties of the tumor. The aim of this study was to determine whether purine metabolites are carried by exosomes and evaluate their role as potential contributors to tumor immune escape. The gene expression levels of the purine synthesis pathway were studied using the Cancer Genome Atlas (TCGA) Head and Neck Cancer database. Read More

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http://dx.doi.org/10.3390/cancers12061602DOI Listing

Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics.

iScience 2020 Jun 2;23(6):101229. Epub 2020 Jun 2.

Department of Medicine, Harvard Medical School, Boston, MA, USA; Division of Engineering in Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to interpret the response dynamics of a clinically prescribed PD-1 inhibitor, nivolumab, in head and neck squamous cell carcinoma (HNSCC) biopsies (N = 50). Using biological assays, we show that drug-induced variance stratifies samples by T helper type 1 (Th1)-related pathways. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303667PMC

Transoral robotic surgery in head and neck district: a retrospective study on 67 patients treated in a single center.

Infect Agent Cancer 2020 15;15:40. Epub 2020 Jun 15.

Maxillofacial & ENT surgery Unit, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", via M. Semmola, Naples, Italy.

Background: The anatomical complexity of the oropharynx and the difficulty in reaching its distal portion have always conditioned the surgical accessibility.Robotic surgery represents an excellent alternative in the treatment of cervico-facial oncological diseases.

Methods: This series comprises all patients managed for head and neck cancer by Trans Oral Robotic Surgery TORS. Read More

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http://dx.doi.org/10.1186/s13027-020-00306-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296635PMC

Functional Landscape of Dysregulated MicroRNAs in Oral Squamous Cell Carcinoma: Clinical Implications.

Front Oncol 2020 12;10:619. Epub 2020 May 12.

Saroj Gupta Cancer Centre and Research Institute, Kolkata, India.

MicroRNA (miRNA) dysregulation is associated with the pathogenesis of oral squamous cell carcinoma (OSCC), and its elucidation could potentially provide information on patient outcome. A growing body of translational research on miRNA biology is focusing on precision oncology, aiming to decode the miRNA regulatory network in the development and progression of cancer. Tissue-specific expression and stable presence in all body fluids are unique features of miRNAs, which could be potentially exploited in the clinical setting. Read More

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http://dx.doi.org/10.3389/fonc.2020.00619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274490PMC

Loss of PTEN sensitizes head and neck squamous cell carcinoma to 5-AZA-2'-deoxycytidine.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 16. Epub 2020 May 16.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. Electronic address:

Objective: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer associated with poor survival. Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene involved in the maintenance of stem cells. DNA methylation is a known epigenetic modification involved in tumor progression. Read More

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http://dx.doi.org/10.1016/j.oooo.2020.05.001DOI Listing

The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020.

Cancers (Basel) 2020 Jun 11;12(6). Epub 2020 Jun 11.

Head and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Cancers that arise in the head and neck region are comprised of a heterogeneous group of malignancies that include carcinogen- and human papillomavirus (HPV)-driven mucosal squamous cell carcinoma as well as skin cancers such as cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, and Merkel cell carcinoma. These malignancies develop in critical areas for eating, talking, and breathing and are associated with substantial morbidity and mortality despite advances in treatment. Understanding of advances in the management of these various cancers is important for all multidisciplinary providers who care for patients across the cancer care continuum. Read More

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http://dx.doi.org/10.3390/cancers12061543DOI Listing

Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer.

Cancers (Basel) 2020 Jun 11;12(6). Epub 2020 Jun 11.

UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.

Cetuximab, an anti-EGFR monoclonal antibody (mAb), is approved for advanced head and neck squamous cell carcinoma (HNSCC) but benefits a minority. An established tumor-intrinsic resistance mechanism is cross-talk between the EGFR and hepatocyte growth factor (HGF)/cMet pathways. Dual pathway inhibition may overcome cetuximab resistance. Read More

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http://dx.doi.org/10.3390/cancers12061537DOI Listing

Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer.

Comput Struct Biotechnol J 2020 13;18:1238-1248. Epub 2020 May 13.

Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, China.

Classical microRNA (miRNA) has been so far believed as a single sequence, but it indeed contains multiple miRNA isoforms (isomiR) with various sequences and expression patterns. It is not clear whether these diverse isomiRs have potential relationships and whether they contribute to miRNA:mRNA interactions. Here, we aimed to reveal the potential evolutionary and functional relationships of multiple isomiRs based on let-7 and miR-10 gene families that are prone to clustering together on chromosomes. Read More

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http://dx.doi.org/10.1016/j.csbj.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280754PMC

Detection of Head and Neck Cancer Based on Longitudinal Changes in Serum Protein Abundance.

Cancer Epidemiol Biomarkers Prev 2020 Jun 12. Epub 2020 Jun 12.

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington.

Background: Approximately 85% of the U.S. military active duty population is male and less than 50 years of age, with elevated levels of known risk factors for oropharyngeal squamous cell carcinoma (OPSCC), including smoking, excessive use of alcohol, and greater numbers of sexual partners, and elevated prevalence of human papilloma virus (HPV). Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-20-0192DOI Listing
June 2020
4.125 Impact Factor

Association of Genetic Variants in ANGPT/TEK and VEGF/VEGFR with Progression and Survival in Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy or Radiochemotherapy.

Cancers (Basel) 2020 Jun 9;12(6). Epub 2020 Jun 9.

I Radiation and Clinical Oncology Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.

Angiogenesis is essential for growth, progression, and metastasis of solid tumors. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) and angiopoietin (ANGPT)/ tyrosine kinase endothelial (TEK) signaling plays an important role in regulating angiogenesis. Very little is known about the effects of single-nucleotide polymorphisms (SNPs) in angiogenesis-related genes on treatment outcome in head and neck squamous cell carcinoma (HNSCC). Read More

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http://dx.doi.org/10.3390/cancers12061506DOI Listing

Induction of ZCCHC6 expression in peripheral blood mononuclear cells by HNSCC secretions.

Gene 2020 Jun 9;754:144880. Epub 2020 Jun 9.

Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand. Electronic address:

Cancer secretion can change the properties of adjacent cells, including peripheral blood mononuclear cells (PBMCs). We investigated whether such secretion influences messenger RNA expression in PBMCs of patients with head and neck squamous cell carcinoma (HNSCC). In the present study, co-culture model of normal PBMCs and HNSCC cell lines were established. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144880DOI Listing

Squamous Cell Carcinoma of the Oral Tongue in Young Patients: Outcomes and Implications for Treatment.

Indian J Surg Oncol 2020 Jun 22;11(2):274-280. Epub 2020 Feb 22.

Department of Head and Neck Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Ponekkara PO, Kochi, 682 041 India.

Squamous cell carcinoma oral tongue (SCCOT) in patients below 45 years is relatively uncommon in literature; however, there have been increasing trends in incidence. Previous studies showed conflicting data, with no conclusive evidence of differences in outcome compared with older patients. The aim of our study was to determine if younger patients with tongue cancer in India had different clinico-pathological characteristics, prognostic determinants or survival than their older counterparts. Read More

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http://dx.doi.org/10.1007/s13193-020-01049-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260305PMC

ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.

Oncogene 2020 Jun 7;39(26):4970-4982. Epub 2020 Jun 7.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Cancer stem cells (CSCs) are cells within tumors that maintain the ability to self-renew, drive tumor growth, and contribute to therapeutic resistance and cancer recurrence. In this study, we investigate the role of Zinc finger and SCAN domain containing 4 (ZSCAN4) in human head and neck squamous cell carcinoma (HNSCC). The murine Zscan4 is involved in telomere maintenance and genomic stability of mouse embryonic stem cells. Read More

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http://dx.doi.org/10.1038/s41388-020-1333-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314663PMC

Pericyte in Oral Squamous Cell Carcinoma: A Systematic Review.

Head Neck Pathol 2020 Jun 6. Epub 2020 Jun 6.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

The microenvironment of oral cancer is highly dynamic and has been proved to affect tumor progression. Pericytes are blood vessels surrounding cells that have recently gained attention for their roles in vascular and cancer biology. The objective of the present study was to survey the scientific literature for conclusive evidence about whether pericytes are part of blood vessels in oral squamous cell carcinoma (OSCC) and their roles in the tumor microenvironment and clinical outcomes. Read More

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http://dx.doi.org/10.1007/s12105-020-01188-2DOI Listing

HPV-related squamous cell carcinoma of oropharynx: a review.

Authors:
Siavash Rahimi

J Clin Pathol 2020 Jun 4. Epub 2020 Jun 4.

Frontier Pathology-Histopathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, Brighton and Hove, UK

In early 1930, R. E. Shope paved the way for the recognition of human papillomavirus (HPV) as a causative agent of some types of cancers. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206686DOI Listing

WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck.

Neoplasia 2020 Aug 16;22(8):283-293. Epub 2020 May 16.

Department of Medicine, University of Chicago, Chicago, USA; Department of Surgery, University of Chicago, Chicago, USA.

Squamous cell carcinoma of the head and neck (SCCHN) is a malignancy with poor outcomes, thus novel therapies are urgently needed. We recently showed that WHSC1 is necessary for the viability of SCCHN cells through H3K36 di-methylation. Here, we report the identification of its novel substrate, histone H1, and that WHSC1-mediated H1. Read More

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http://dx.doi.org/10.1016/j.neo.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265065PMC

Radiomic biomarkers for head and neck squamous cell carcinoma.

Strahlenther Onkol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Rämistraße 100, 8091, Zurich, Switzerland.

Tumor heterogeneity is a well-known prognostic factor in head and neck squamous cell carcinoma (HNSCC). A major limitation of tissue- and blood-derived tumor markers is the lack of spatial resolution to image tumor heterogeneity. Tissue markers derived from tumor biopsies usually represent only a small tumor subregion at a single timepoint and are therefore often not representative of the tumors' biology or the biological alterations during and after treatment. Read More

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http://dx.doi.org/10.1007/s00066-020-01638-4DOI Listing

Trends and clinicopathological characteristics of oral squamous cell carcinomas reported at a tertiary cancer hospital in Nepal during 1999 to 2009.

Clin Exp Dent Res 2020 Jun 12;6(3):356-362. Epub 2020 Jan 12.

Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Objective: Reliable data describing the trends and clinicopathological characteristics of oral squamous cell carcinoma (OSCC) in the Nepalese population are very limited. The current study aimed to examine the demographics, trend, and clinicopathological characteristics of OSCC reported to the main referral/tertiary cancer hospital, the B.P. Read More

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http://dx.doi.org/10.1002/cre2.278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301398PMC

Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis.

Mol Cancer 2020 06 2;19(1):99. Epub 2020 Jun 2.

Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.

Background: Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck. LSCC patients have seriously impaired vocal, respiratory, and swallowing functions with poor prognosis. Circular RNA (circRNA) has attracted great attention in cancer research. Read More

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http://dx.doi.org/10.1186/s12943-020-01215-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265647PMC
June 2020
4.257 Impact Factor

Correction: Stalder, et al.; Value of SUV for the Prediction of Bone Invasion in Oral Squamous Cell Carcinoma. 2020, , 23.

Biology (Basel) 2020 May 29;9(6). Epub 2020 May 29.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.

The authors would like to make a correction to their published paper [1][... Read More

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http://dx.doi.org/10.3390/biology9060113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344941PMC

Management of Fanconi Anemia patients with head and neck carcinoma: Diagnosis and treatment adaptation.

Oral Oncol 2020 May 29;108:104816. Epub 2020 May 29.

Department of Radiation Oncology, François Baclesse Center, Caen, France.

Fanconi anemia (FA) is a rare genetic disease that is mostly transmitted, according to a recessive model with biallelic germline alterations in one of the 22 genes of the FA pathway, or monoallelic alteration of the 23rd FA gene (RAD51). The FA pathway is implicated in interstrand DNA crosslink repair, induces genome stability, and is a potent driver of tumorigenesis. Patients with FA have a 500 to 1000-fold increased risk of developing head and neck squamous cell carcinoma (HNSCC). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104816DOI Listing

PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.

Mol Cancer Res 2020 May 28. Epub 2020 May 28.

Department of Otolaryngology - Head & Neck Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.

EGFR inhibitors have shown poor efficacy in head and neck squamous cell carcinoma (HNSCC) with demonstrated involvement of the insulin-like growth factor-1 receptor (IGF1R) in resistance to EGFR inhibition. IGF1R activates the PI3K-Akt pathway, which phosphorylates proline-rich Akt substrate of 40 kDa (PRAS40) to cease mTOR inhibition resulting in increased mTOR signaling. Proliferation assays separated six HNSCC cell lines into two groups: sensitive to EGFR inhibition or resistant; all sensitive cell lines demonstrated reduced sensitivity to EGFR inhibition upon IGF1R activation. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0592DOI Listing

An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer.

Cancers (Basel) 2020 May 22;12(5). Epub 2020 May 22.

Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan.

Although many studies have shown the association between smoking and the increased incidence and adverse prognosis of head and neck squamous cell carcinoma (HNSCC), the mechanisms and pharmaceutical targets involved remain unclear. Here, we integrated gene expression signatures, genetic alterations, and survival analyses to identify prognostic indicators and therapeutic targets for smoking HNSCC patients, and we discovered that the FDA-approved drug varenicline inhibits the target for cancer cell migration/invasion. We first identified 18 smoking-related and prognostic genes for HNSCC by using RNA-Seq and clinical follow-up data. Read More

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http://dx.doi.org/10.3390/cancers12051324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281299PMC

Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy.

PLoS One 2020 22;15(5):e0232639. Epub 2020 May 22.

The D-lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Introduction: In this study, we investigate the role of radiomics for prediction of overall survival (OS), locoregional recurrence (LRR) and distant metastases (DM) in stage III and IV HNSCC patients treated by chemoradiotherapy. We hypothesize that radiomic analysis of (peri-)tumoral tissue may detect invasion of surrounding tissues indicating a higher chance of locoregional recurrence and distant metastasis.

Methods: Two comprehensive data sources were used: the Dutch Cancer Society Database (Alp 7072, DESIGN) and "Big Data To Decide" (BD2Decide). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244120PMC

Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing.

PLoS One 2020 21;15(5):e0233380. Epub 2020 May 21.

Moores Cancer Center, University of California San Diego, San Diego, California, United States of America.

Alternative mRNA splicing increases protein diversity, and alternative splicing events (ASEs) drive oncogenesis in multiple tumor types. However, the driving alterations that underlie the broad dysregulation of ASEs are incompletely defined. Using head and neck squamous cell carcinoma (HNSCC) as a model, we hypothesized that the genomic alteration of genes associated with the spliceosome may broadly induce ASEs across a broad range of target genes, driving an oncogenic phenotype. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233380PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241804PMC

A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.

Int J Exp Pathol 2020 Feb 21;101(1-2):45-54. Epub 2020 May 21.

Department of Diagnostic and Biomedical Sciences, University of Texas School of Dentistry, Houston, TX, USA.

Oral cancer causes significant global mortality and has a five-year survival rate of around 64%. Poor prognosis results from late-stage diagnosis, highlighting an important need to develop better approaches to detect oral premalignant lesions (OPLs) and identify which OPLs are at highest risk of progression to oral squamous cell carcinoma (OSCC). An appropriate animal model that reflects the genetic, histologic, immunologic, molecular and gross visual features of human OSCC would aid in the development and evaluation of early detection and risk assessment strategies. Read More

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http://dx.doi.org/10.1111/iep.12347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306900PMC
February 2020

An integrated approach for preventing oral cavity and oropharyngeal cancers: two etiologies with distinct and shared mechanisms of carcinogenesis.

Cancer Prev Res (Phila) 2020 May 20. Epub 2020 May 20.

Public Health Sciences, Penn State College of Medicine.

Head and neck squamous cell carcinoma (HNSCC) was the 7th most common malignancy worldwide in 2018 and despite therapeutic advances, the overall survival rate for oral squamous cell carcinoma (OSCC) (~50%) has remained unchanged for decades. The most common types are OSCC and oropharyngeal squamous cell carcinoma (OPSCC, survival rate ~85%). Tobacco smoking is a major risk factor of HNSCC. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-20-0096DOI Listing

Anti-C1GALT1 Autoantibody Is a Novel Prognostic Biomarker for Patients With Head and Neck Cancer.

Laryngoscope 2020 May 19. Epub 2020 May 19.

Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

Objectives: The objective of this study is to determine the value of the anti- glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) autoantibody as a biomarker for distant metastasis and good response to immune checkpoint inhibitors in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: In this retrospective study with a median follow-up of 55.7 months, 186 HNSCC patients were enrolled between July 2013 and August 2014. Read More

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http://dx.doi.org/10.1002/lary.28694DOI Listing
May 2020
2.032 Impact Factor

UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells.

Oncoimmunology 2020 5;9(1):1743036. Epub 2020 Apr 5.

Department of Radioimmunology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.

Induction or selection of radioresistant cancer (stem) cells following standard radiotherapy is presumably one of the major causes for recurrence of metastatic disease. One possibility to prevent tumor relapse is the application of targeted immunotherapies including, e.g. Read More

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http://dx.doi.org/10.1080/2162402X.2020.1743036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219270PMC

Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC.

Br J Cancer 2020 May 19. Epub 2020 May 19.

Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Background: Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted in silico prognostic evaluation of the EGFR-MAPK axis in HNSCC.

Methods: Expression of ERK1/2 phosphorylation (pERK1/2) was determined in HNSCC cell lines, which were treated with cetuximab or fractionated-IR. Read More

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http://dx.doi.org/10.1038/s41416-020-0892-9DOI Listing

MicroRNA Expression Profiling of Cutaneous Squamous Cell Carcinomas Arising in Different Sites.

Otolaryngol Head Neck Surg 2020 May 19:194599820918855. Epub 2020 May 19.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

Objective: To examine the microRNA (miRNA) expression profile of cutaneous squamous cell carcinoma (cSCC) tumors from aggressive head and neck locations compared with nonaggressive anatomic sites and normal controls.

Study Design: Retrospective analysis of miRNA expression.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599820918855DOI Listing

Implantation of Squamous Cell Carcinoma in a Free Flap Donor Site.

Ann Otol Rhinol Laryngol 2020 May 17:3489420917418. Epub 2020 May 17.

Department of Otolaryngology-Head & Neck Surgery, Geisinger Medical Center, Danville, PA, USA.

Introduction: It is well known that malignant cells can be implanted at distant donor sites due to iatrogenic surgical contamination. Only a small number of reports, however, have been published describing this.

Case Presentation: We present a case of oral cavity Squamous Cell Carcinoma (SCC) reconstructed with a radial forearm free flap in which SCC developed in the subcutaneous tissues beneath the donor incision site 6 months after surgery. Read More

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http://dx.doi.org/10.1177/0003489420917418DOI Listing

Randomized controlled trial to identify the optimal radiotherapy scheme for palliative treatment of incurable head and neck squamous cell carcinoma.

Radiother Oncol 2020 May 14;149:181-188. Epub 2020 May 14.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, the Netherlands.

Background: No randomized controlled trials (RCT) have yet identified the optimal palliative radiotherapy scheme in patients with incurable head and neck squamous cell carcinoma (HNSCC). We conducted RCT to compare two radiation schemes in terms of efficacy, toxicity and quality-of-life (QoL).

Materials And Methods: Patients with locally-advanced HNSCC who were ineligible for radical treatment and those with limited metastatic disease were randomly assigned in 1:1 ratio to arm 1 (36 Gy in 6 fractions, twice a week) or arm 2 (50 Gy in 16 fractions, four times a week). Read More

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http://dx.doi.org/10.1016/j.radonc.2020.05.020DOI Listing

Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA.

Oncogene 2020 Jun 15;39(24):4741-4755. Epub 2020 May 15.

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.

Human papilloma virus (HPV)-associated oropharyngeal cancer (OPC) is an independent tumour type with regard to cellular, biological, and clinical features. The use of non-invasive biomarkers such as circulating tumour DNA (ctDNA) may be relevant in early diagnosis and eventually improve the outcomes of patients with head and neck squamous cell carcinoma (HNSCC). Genome-wide discovery using RNA sequencing and reduced representation bisulfite sequencing yielded 21 candidates for methylation-targeted genes. Read More

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http://dx.doi.org/10.1038/s41388-020-1327-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286817PMC

Epithelial-to-mesenchymal transition is a prognostic marker for patient outcome in advanced stage HNSCC patients treated with chemoradiotherapy.

Radiother Oncol 2020 Jun 13;147:186-194. Epub 2020 May 13.

Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Background: The prognosis of patients with HPV-negative advanced stage head and neck squamous cell carcinoma (HNSCC) remains poor. No prognostic markers other than TNM staging are routinely used in clinic. Epithelial-to-mesenchymal transition (EMT) has been shown to be a strong prognostic factor in other cancer types. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.05.013DOI Listing

Cell Surface Labeling by Engineered Extracellular Vesicles.

Adv Biosyst 2020 May 10:e2000007. Epub 2020 May 10.

Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, OR, USA.

Extracellular vesicles (EVs) can mediate local and long-range intercellular communication via cell surface signaling. In order to perform in vivo studies of unmanipulated, endogenously released EVs, sensitive but stringent approaches able to detect EV-cell surface interactions are needed. However, isolation and reinfusion of EVs can introduce biases. Read More

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http://dx.doi.org/10.1002/adbi.202000007DOI Listing

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials.

Int J Mol Sci 2020 May 6;21(9). Epub 2020 May 6.

Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.

Oral cancer (OC) is a devastating disease that takes the lives of lots of people globally every year. The current spectrum of treatment modalities does not meet the needs of the patients. The disease heterogeneity demands personalized medicine or targeted therapies. Read More

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http://dx.doi.org/10.3390/ijms21093285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246494PMC

MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.

Life Sci Alliance 2020 Jun 7;3(6). Epub 2020 May 7.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC). Unexpectedly, MAPK pathway aberrations are associated with remarkably long patient survival, even among patients with mutations (median ∼14 yr). We explored underlying outcome-favoring mechanisms with omics followed by preclinical models. Read More

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http://dx.doi.org/10.26508/lsa.201900545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219112PMC