Selenocysteine inhibits human osteosarcoma cells growth through triggering mitochondrial dysfunction and ROS-mediated p53 phosphorylation.
Cell Biol Int 2018 Jan 11. Epub 2018 Jan 11.
Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China.
Osteosarcoma represents the most common primary malignant bone tumor in children and adolescents, which shows severe resistance towards standard chemotherapy because of high invasive capacity and growing incidence. Selenocystine (SeC) is a naturally available Se-containing amino acid that displays splendid anticancer activities against several human tumors. However, little information about SeC-induced growth inhibition against human osteosarcoma is available. Read More