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    Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways.
    Cell Biol Int 2017 Sep 16. Epub 2017 Sep 16.
    Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
    Fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) play essential roles in bone formation and osteoblast activity through the extracellular signal regulated kinase 1/2 (ERK1/2) and Smad pathways. Sprouty family members are intracellular inhibitors of the FGF signaling pathway, and four orthologs of Sprouty have been identified in mammals. In vivo analyses have revealed that Sprouty2 is associated with bone formation. Read More

    A Role for the Non-receptor Tyrosine Kinase ACK1 in TNF-alpha-mediated Apoptosis and Proliferation in Human Intestinal Epithelial Caco-2 Cells.
    Cell Biol Int 2017 Sep 16. Epub 2017 Sep 16.
    Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    The roles of tumor necrosis factor alpha (TNF-alpha) and its mediators in cellular processes related to intestinal diseases remain elusive. In this study, we aimed to determine the biological role of activated Cdc42-associated kinase 1 (ACK1) in TNF-alpha-mediated apoptosis and proliferation in Caco-2 cells. ACK1 expression was knocked down using ACK1-specific siRNAs, and ACK1 activity was disrupted using a small molecule ACK1 inhibitor. Read More

    The toxic alpha-gliadin peptide 31-43 enters cells without a surface membrane receptor.
    Cell Biol Int 2017 Sep 15. Epub 2017 Sep 15.
    Chemistry and Biology, University of Salerno, Fisciano, Italy.
    Alpha-gliadin peptide 31-43 is considered to be the main peptide responsible for the innate immune response in celiac disease patients. Recent evidence indicates that peptide 31-43 rapidly enters cells and interacts with the early endocytic vesicular compartment. However, the mechanism of its uptake is not completely understood. Read More

    β-Carotene Suppresses Porphyromonas gingivalis Lipopolysaccharide-mediated Cytokine Production in THP-1 Monocytes Cultured with High Glucose Condition.
    Cell Biol Int 2017 Sep 14. Epub 2017 Sep 14.
    Department of Periodontology and Endodontology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8504, Japan.
    Periodontitis is associated with development of diabetes mellitus. Although lipopolysaccharide (LPS) of Porphyromonas gingivalis (Pg), a major pathogen of periodontitis, may lead the progression of diabetes complications, the precise mechanisms are unclear. We, therefore, investigated the effects of β-carotene on production of Pg LPS-induced inflammatory cytokines in human monocytes cultured high glucose (HG) condition. Read More

    Collagen Peptides Modulates the Metabolism of Extracellular Matrix by Human Dermal Fibroblasts Derived from Sun-Protected and Sun-Exposed Body Sites.
    Cell Biol Int 2017 Sep 14. Epub 2017 Sep 14.
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1524, Sao Paulo, SP, Brazil, 05508-000.
    Clinical data published in recent years has demonstrated positive effects of collagen hydrolysate (CH) on skin aging clinical signs. CH use as food supplement has a long history; however, few studies have addressed the underlying purpose of CH on the cellular and molecular biology of skin cells that could elucidate clinical improvement findings. Wide diversity of characteristics has been reported for dermal fibroblasts derived from different body sites and it is unknown whether collagen peptides could modulate differently cells from chronological aged and photoaged skin areas. Read More

    CDP-choline Circumvents Mercury-induced Mitochondrial Damage and Renal Dysfunction.
    Cell Biol Int 2017 Sep 8. Epub 2017 Sep 8.
    Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez México, D. F. México.
    Heavy metal ions are known to produce harmful alterations on kidney function. Specifically, the accumulation of Hg(2+) in kidney tissue may induce renal failure. In this work the protective effect of CDP-choline against the deleterious effects induced by Hg(2+) on renal function were studied. Read More

    miRNA-4317 Suppresses Human Gastric Cancer Cell Proliferation by Targeting ZNF322.
    Cell Biol Int 2017 Sep 7. Epub 2017 Sep 7.
    Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
    Studies have shown that miR-4317 is dysregulated in tumor, but the biologic role of miR-4317 in tumor development and progression remains unknown. The present study aimed to investigate the role of miR-4317 in human gastric cancer. Quantitative real-time PCR was used to quantify miR-4317 expression levels in clinical gastric cancer specimens and cell lines. Read More

    Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
    Cell Biol Int 2017 Sep 7. Epub 2017 Sep 7.
    Pharmacology Department, Dalian Medical University, 9 West Section, South Road of Lvshun, Dalian, China.
    The signal transducers and activators of transcription 3 (STAT3) signaling pathway is a common feature in many solid tumors including non-small cell lung cancer, whereas current therapies usually fail to treat this disease in majority of cases. In the present study, we aimed to investigate the cytotoxic effect and the underlying mechanisms of SZC017, an oleanolic acid derivative, on human lung cancer cells. Cell viability was significantly decreased in SZC017-treated lung cancer cells. Read More

    Exosomes secreted from mutant-HIF-1α-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit.
    Cell Biol Int 2017 Sep 6. Epub 2017 Sep 6.
    The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
    Mesenchymal stem cells (MSCs)-derived exosomes exhibit protective effects on damaged or diseased tissues. Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in bone development. However, HIF-1α is easily biodegradable under normoxic conditions. Read More

    Desquamation takes center stage at the origin of proliferative inflammatory atrophy, epithelial-mesenchymal transition and stromal growth in benign prostate hyperplasia.
    Cell Biol Int 2017 Sep 6. Epub 2017 Sep 6.
    Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas SP, Brazil.
    In this commentary we propose a relationship between desquamation, initially described as the collective detachment and deletion of epithelial cell in the prostate gland after castration, and proliferative inflammatory atrophy (PIA) and stromal growth in benign prostate hyperplasia (BPH). First, in response to diverse stimuli, including inflammatory mediators, epithelial cells desquamate and leave a large surface of the luminal side of the basement membrane (BM) exposed. Basal cells are activated into intermediate-type cells, which change morphology to cover and remodel the exposed BM (simple atrophy) to a new physiological demand (such as in the hypoandrogen environment, simulated by surgical and/or chemical castration) and/or to support re-epithelialization (under normal androgen levels). Read More

    SIRT1 mediates salidroside-elicited protective effects against MPP(+) -induced apoptosis and oxidative stress in SH-SY5Y cells: Involvement in suppressing MAPK pathways.
    Cell Biol Int 2017 Aug 29. Epub 2017 Aug 29.
    Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China.
    Parkinson's disease (PD) is a progressive neurodegenerative disease, leading to tremor, rigidity, bradykinesia and gait impairment. Salidroside has been reported to exhibit antioxidative and neuroprotective properties in PD. However, the underlying neuroprotective mechanisms effects of salidroside are poorly understood. Read More

    Macrophage migration inhibitory factor (MIF) promotes rat airway muscle cell proliferation and migration mediated by ERK1/2 and FAK signaling.
    Cell Biol Int 2017 Aug 29. Epub 2017 Aug 29.
    Research Center of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    Macrophage migration inhibitory factor (MIF) is an inflammatory mediator that contributes to asthmatic airway remodeling; however, little is known regarding the effects of MIF on airway smooth muscle cells (ASMCs). In the present study, we found that an enhanced expression of MIF promoted ASMC proliferation, increased the population of cells in the S/G2 phase, downregulated P21 expression, and upregulated cyclin D1, cyclin D3, and Cdk6 expression. In addition, the apoptosis of ASMCs was significantly decreased in response to MIF overexpression, compared with the negative control. Read More

    4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.
    Cell Biol Int 2017 Aug 29. Epub 2017 Aug 29.
    Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China.
    Dysregulation of histone acetylation plays an important role in tumor development. Histone acetylation regulates gene transcription and expression, which is reversibly regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC). As an HDAC inhibitor, 4-phenylbutyric acid (4-PBA) can increase histone acetylation levels by inhibiting HDAC activity. Read More

    Wnt5a regulates the cell proliferation and adipogenesis via MAPK-independent pathway in early stage of obesity.
    Cell Biol Int 2017 Aug 29. Epub 2017 Aug 29.
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China.
    The early stage of obesity is an important stage in the development of obesity. However there are few studies which explored the property or changes in obesity at early stage especially involving Wnt5a. The associated gene expression of Wnt5a on cell regeneration and the effect of Wnt5a on rat adipocyte-derived stem cell (rASC) proliferation and adipogenesis need additional study. Read More

    Comparative study of hematopoietic stem and progenitor cells between sexes in mice under physiological conditions along time.
    Cell Biol Int 2017 Aug 29. Epub 2017 Aug 29.
    LAGENBIO, Veterinary Faculty of Zaragoza, Instituto Agroalimentario de Aragón (IA2), IIS Aragón, University of Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain.
    Hematopoietic stem and progenitor cells (HSPCs) are attractive targets in regenerative medicine, although the differences in their homeostatic maintenance between sexes along time are still under debate. We accurately monitored hematopoietic stem cells (HSCs), common lymphoid progenitors (CLPs), and common myeloid progenitors (CMPs) frequencies by flow cytometry, by performing serial peripheral blood extractions from male and female B6SJL wild-type mice and found no significant differences. Only modest differences were found in the gene expression profile of Slamf1 and Gata2. Read More

    Simultaneous targeted inhibition of Sox2-Oct4 transcription factors using decoy oligodeoxynucleotides to repress stemness properties in mouse embryonic stem cells.
    Cell Biol Int 2017 Aug 18. Epub 2017 Aug 18.
    Biology Group, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran.
    Transcriptional master regulators like Sox2 and Oct4, which are expressed in various human tumors, have been shown to cause tumor growth promotion as well as epithelial dysplasia by means of interfering with progenitor cell differentiation. In order to investigate the potential of Sox2-Oct4 transcription factor decoy (TFD) strategy for differentiation therapy, mouse embryonic stem cells (mESCs) were used in this study as a model of cancer stem cells (CSCs). Sox2-Oct4 complex decoy ODNs (cd-ODNs) were designed according to their elements in the promoter region of Sox2 gene. Read More

    A Novel Model to Characterize Structure and Function of BRCA1.
    Cell Biol Int 2017 Aug 18. Epub 2017 Aug 18.
    Isar Klinikum 80331 Munich, Sonnenstr 24-26, Germany.
    BRCA1 plays a central role in DNA repair. Although N-terminal RING and C-terminal BRCT domains are studied, the functions of the central region of BRCA1 is poorly characterized. Here we report a structural and functional analysis of BRCA1 alleles and functional human BRCA1 in chicken B-lymphocyte cell line DT40. Read More

    Depletion of HOXA5 inhibits the osteogenic differentiation and proliferation potential of stem cells from the apical papilla.
    Cell Biol Int 2017 Aug 22. Epub 2017 Aug 22.
    Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
    Mesenchymal stem cells (MSCs) are a prospective cell source for tissue regeneration due to their self-renewal abilities and potential to differentiate into different cell lineages, but the molecular mechanisms of the directed differentiation and proliferation are still unknown. Recently, multiple studies have indicated the crucial role of HOX genes in MSC differentiation and proliferation. However, the role of HOXA5 in MSCs remains unknown. Read More

    Tacrolimus regulates endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation: in vitro and collagen-induced arthritis mouse model.
    Cell Biol Int 2017 Aug 22. Epub 2017 Aug 22.
    Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea.
    Tacrolimus is an immunosuppressive drug that inhibits the release of inflammatory cytokines involved in rheumatoid arthritis development by blocking T cell activation. "Endoplasmic reticulum stress," an imbalance between protein folding load and capacity leading to the accumulation of unfolded proteins in the endoplasmic reticulum lumen, has been implicated in rheumatoid arthritis and other inflammatory and metabolic diseases. We aimed to investigate the effect of tacrolimus on endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation and elucidate the underlying mechanisms. Read More

    Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts.
    Cell Biol Int 2017 Aug 18. Epub 2017 Aug 18.
    Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
    Dermal fibroblasts generate the extracellular matrix component elastin, which is synthesized as tropoelastin (TE) and play a critical role in maintaining skin elasticity. Lactoferrin (Lf), an 80-kDa iron-binding glycoprotein, has biological functions such as anti-bacterial, -inflammatory, and -cancer activities. We previously reported that bovine Lf increases TE mRNA expression in human dermal fibroblasts. Read More

    KLK14 interactions with HAI-1 and HAI-2 serine protease inhibitors: A molecular dynamics and relative free-energy calculations study.
    Cell Biol Int 2017 Aug 17. Epub 2017 Aug 17.
    Department of Structural and Functional Biology, State University of Campinas, Campinas, São Paulo, Brazil.
    Kallikrein 14 (KLK14) is a serine protease linked to several pathologies including prostate cancer and positively correlates with Gleason score. Though KLK14 functioning in cancer is poorly understood, it has been implicated in HGF/Met signaling, given that KLK14 proteolytically inhibits HGF activator-inhibitor 1 (HAI-1), which strongly inhibits pro-HGF activators, thereby contributing to tumor progression. In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. Read More

    Tubulin acetylation accompanies autophagy development induced by different abiotic stimuli in Arabidopsis thaliana.
    Cell Biol Int 2017 Aug 17. Epub 2017 Aug 17.
    Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
    Microtubules (MTs) play an important role in the regulation of autophagy development in yeast and animal as well as in plant cells. MTs participate in maturation and traffic of autophagosomes through their dynamic state changes and post-translational modifications of tubulin, namely acetylation. We subjected Arabidopsis thaliana seedlings to metabolic-, salt-, osmotic stresses as well as irradiation of ultraviolet B and investigated the involvement of plant MTs in the development of stress-induced autophagy via tubulin acetylation. Read More

    Porcine spermatogonial stem cells self-renew effectively in a three dimensional culture microenvironment.
    Cell Biol Int 2017 Aug 17. Epub 2017 Aug 17.
    Department of Animal Life Science, Kangwon National University, Chuncheon 24341, Korea.
    Generally, self-renewal of spermatogonial stem cells (SSCs) is maintained in vivo in a three-dimensional (3D) microenvironment consisting of the seminiferous tubule basement membrane, indicating the importance of the 3D microenvironment for in vitro culture of SSCs. Here, we report a 3D culture microenvironment that effectively maintains porcine SSC self-renewal during culture. Porcine SSCs were cultured in an agarose-based 3D hydrogel and in 2D culture plates either with or without feeder cells. Read More

    Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage.
    Cell Biol Int 2017 Aug 17. Epub 2017 Aug 17.
    Department of Cardiovascular Surgery, Renmin Hospital, Wuhan University, Wuhan, P.R. China.
    Increased levels of S100A12 and activated matrix metalloproteinase 2/9 (MMP-2/9) produced by human aortic smooth muscle cells (HASMCs) have recently implicated in the development of thoracic aortic disease. In the present study, we investigated the effect of S100A12 on HASMCs and identified the intracellular signal pathways involved by Western blot. The results were shown that up-expression of S100A12 in HASMCs induced cell apoptosis and inhibited cell proliferation. Read More

    Cytoskeleton and nucleoskeleton involvement in processes of cytomixis in plants.
    Cell Biol Int 2017 Aug 17. Epub 2017 Aug 17.
    Institute of Food Biotechnology and Genomics, Natl. Academy of Sciences of Ukraine, Kyiv, Ukraine.
    Cytomixis is a form of cell-to-cell nuclear migration that involves the interaction of dynamic cytoskeletal components with the nucleus through signalling systems and linker complexes. In cytomixis two known mechanisms can be involved: actomyosin and/or microtubules and their associated motors. Perinuclear actin anchors and determines the direction of nuclear movement. Read More

    Differential expression and androgen regulation of microRNAs and metalloprotease 13 in breast cancer cells.
    Cell Biol Int 2017 Aug 17. Epub 2017 Aug 17.
    School of Medicine, Department of Pharmacology, The University of Jordan, Amman, Jordan.
    MicroRNA molecules (miRNAs) play important roles in regulating cell behavior. The expression of certain miRNAs has been shown to be regulated by the androgen receptor (AR), which seems to have a critical role in the tumorigenic process of breast cancer. The differential expression of 84 miRNAs was first examined in three breast cancer cell lines: the luminal MCF-7 and T47D cells and the molecular apocrine MDA-MB-453 cells. Read More

    Expression analysis of cellulose synthase and main cytoskeletal protein genes in flax (Linum usitatissimum L.).
    Cell Biol Int 2017 Aug 9. Epub 2017 Aug 9.
    Institute of Food Biotechnology and Genomics, The National Academy of Sciences of Ukraine, Оsipovskogo str., 2A, 04123 Kyiv, Ukraine.
    Fiber flax is an important source of natural fiber and a comprehensive model for the plant fiber biogenesis studies. Cellulose-synthase (CesA) and cytoskeletal genes are known to be important for the cell wall biogenesis in general and for the biogenesis of flax fibers in particular. Currently, knowledge about activity of these genes during the plant growth is limited. Read More

    The combination of miR-122 overexpression and Let-7f silencing induces hepatic differentiation of adipose tissue-derived stem cells.
    Cell Biol Int 2017 Oct 29;41(10):1083-1092. Epub 2017 Aug 29.
    Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
    Human adipose tissue-derived stem cells (hADSCs) have been considered as a promising source for cell therapy of liver diseases due to their accessibility, abundance, and expression of hepatocyte markers. Currently, the important role of certain microRNAs (miRNAs) has been reported during hepatic differentiation of stem cells. However, the combination effect of miRNAs on hepatic differentiation of these cells needs to be more investigated. Read More

    The anti-proliferative effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1.
    Cell Biol Int 2017 Aug 9. Epub 2017 Aug 9.
    Qingdao University Medical College, 308 Ningxia Road, Qingdao 266071, Shandong, China.
    Vascular smooth muscle cell (VSMC) proliferation is a major contributor to atherosclerosis. This study investigated the inhibitory effects of oleanolic acid (OA) against oxidized low-density lipoprotein (ox-LDL)-induced VSMC proliferation in A7r5 cells and explored underlying molecular mechanism. The cell proliferation was quantified with cell counting kit-8 (CCK-8), in which ox-LDL significantly increased A7r5 cells proliferation, while OA pretreatment effectively alleviated such changes without inducing overt cytotoxicity, as indicated by lactate dehydrogenase (LDH) assay. Read More

    High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC-1α/SIRT1 signaling pathway.
    Cell Biol Int 2017 Oct 23;41(10):1146-1159. Epub 2017 Aug 23.
    The Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
    The objective of the research was to investigate the function of endothelial progenitor cells (EPCs) in the conditions of high glucose and lipids, which has been widely used to mimic the metabolic disorder that occurs in type 2 diabetic mellitus, and further to verify the role of PGC-1α and SIRT1, cellular energy metabolism regulators, in the process of senescence of EPCs with these combined stimuli. Circulating EPCs were incubated in absence or presence of high glucose (25 mM), FFA (200 µM) or both. EPCs senescence was assessed by β-galactosidase staining, EPCs telomerase activity was measured by telomeric repeat ampli-fication protocol assay, in vitro angiogenesis assay and MTT assays were performed to assess angiogenesis and proliferation ability of EPCs. Read More

    Differentiation of human dental pulp stem cells into neuronal by resveratrol.
    Cell Biol Int 2017 Aug 7. Epub 2017 Aug 7.
    Department of Prosthodontics, 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China.
    Dental pulp stem cells (DPSCs) have been proposed as a promising source of stem cells in nerve regeneration due to their close embryonic origin and ease of harvest. Resveratrol (RSV) is a natural polyphenolic and possesses many biological functions such as anti-inflammatory activity and protection against atherosclerosis and neuroprotective activities. There is increasing evidence showing that RSV plays a pivotal role in neuron protection and neuronal differentiation. Read More

    Histone deacetylase 11 suppresses p53 expression in pituitary tumor cells.
    Cell Biol Int 2017 Aug 7. Epub 2017 Aug 7.
    School of Medicine, Shandong University, Jinan, 250012, China.
    The pathogenesis of pituitary tumors (PT) is unclear. Deregulation of apoptosis is one of the factors involving tumor growth. Histone deacetylases (HDAC) have an active role in multiple cellular activities. Read More

    TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer.
    Cell Biol Int 2017 Aug 1. Epub 2017 Aug 1.
    School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom.
    TMEFF2 is a type I transmembrane protein with two follistatin (FS) and one EGF-like domain over-expressed in prostate cancer; however its biological role in prostate cancer development and progression remains unclear, which may, at least in part, be explained by its proteolytic processing. The extracellular part of TMEFF2 (TMEFF2-ECD) is cleaved by ADAM17 and the membrane-retained fragment is further processed by the gamma-secretase complex. TMEFF2 shedding is increased with cell crowding, a condition associated with the tumour microenvironment, which was mediated by oxidative stress signalling, requiring jun-kinase (JNK) activation. Read More

    Opposing effects of low versus high concentrations of water soluble vitamins/dietary ingredients Vitamin C and niacin on colon cancer stem cells (CSCs).
    Cell Biol Int 2017 Oct 24;41(10):1127-1145. Epub 2017 Aug 24.
    Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya University, University Road, Mangalore, 575018, Karnataka, India.
    Colorectal cancer is one of the global causes of cancer deaths. Cancer stem cells (CSCs) inside the tumour niche responsible for metastasis and relapses, and hence need to be targeted for cancer therapeutics. Although dietary fibre and lifestyle changes have been recommended as measures for colorectal cancer prevention, no such recommendations are available for using water soluble vitamins as prophylaxis measure for colorectal cancers. Read More

    MiR-376a suppresses the proliferation and invasion of non-small-cell lung cancer by targeting c-Myc.
    Cell Biol Int 2017 Jul 25. Epub 2017 Jul 25.
    Department of Thoracic Surgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu, Sichuan, 610072, China.
    It has been reported that miR-376a is involved in the formation and progression of several types of cancer. However, the expression and function of miR-376a is still unknown in non-small cell lung carcinomas (NSCLC). In this study, the expression of miR-376a in NSCLC tissues and cell lines were examined by real-time PCR, the effects of miR-376a on cell proliferation, apoptosis and invasion were evaluated in vitro. Read More

    Intrauterine exposure to oestradiol promotes sex-specific differential effects on the prostatic development of neonate gerbils.
    Cell Biol Int 2017 Jul 25. Epub 2017 Jul 25.
    Department of Biology, Laboratory of Microscopy and Microanalysis, Univ. Estadual Paulista - UNESP, Rua Cristóvão Colombo, São José do Rio Preto, São Paulo, Brazil.
    The effects of intrauterine exposure to 17β-oestradiol (E2) are well studied for the male prostate and there are accumulating evidences that the exposure to high dosages leads to a hypomorphic development. However, there is a lack of information about the effects of intrauterine exposure to E2 in the prostate of rodent females, and such research becomes relevant in view of the presence of functional prostate in a proportion of women, and the morphophysiological similarities between the prostate of female rodents and the prostate of women. This study uses histochemical, immunohistochemical, immunofluorescence and three-dimensional (3D) reconstruction techniques to evaluate the effects of intrauterine exposure to E2 (500 BW/d) on neonatal prostate development in both male and female gerbils. Read More

    Bioinformatics analysis in menopause transition promotes distinct modulation in calvaria and bone marrow osteoblastic cells.
    Cell Biol Int 2017 Jul 24. Epub 2017 Jul 24.
    Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
    We read with great interest the recent report by Semeghini et al. (2017), Cell Biol Int, "Menopause transition promotes distinct modulation of mRNAs and miRNAs expression in calvaria and bone marrow osteoblastic cells," which appeared on 24 May 2017 in Cell Biology International. The results of the report are very helpful for us; however, from our perspective, the author's method in bioinformatics analysis is inappropriate: Student's t-test is an inappropriate statistical method for detecting differentially expressed mRNA or miRNA in osteoblastic cells from calvaria of ovariectomized rats compared to control or in osteoblastic cells from bone marrow of ovariectomized rats compared to control. Read More

    High glucose induces O-GlcNAc glycosylation of the vitamin D receptor (VDR) in THP1 cells and in human macrophages derived from monocytes.
    Cell Biol Int 2017 Sep 9;41(9):1065-1074. Epub 2017 Aug 9.
    Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Sección XVI, México City, Mexico, 1408.
    Chronic hyperglycemia increases the carbon flux through the hexosamine pathway, allowing the accumulation of UDP-GlcNAc. UDP-GlcNAc is the sugar donor for the enzyme-mediated protein glycosylation event known as OGlcNAcylation. This posttranslational modification targets several transcription factors implicated in glucose toxicity, insulin resistance, and diabetes. Read More

    Cooperation of HIF- and NCAM-mediated mechanisms in cell viability of hippocampal cultures after oxygen-glucose deprivation.
    Cell Biol Int 2017 Oct 6;41(10):1119-1126. Epub 2017 Aug 6.
    Department of Cytology, O.O.Bogomoletz Institute of Physiology, National Academy of Sciences, Kyiv, Ukraine.
    Neurodegenerative diseases of different genesis are the result of cellular damages including those caused by oxygen and glucose deficit. Neuronal survival or death in brain pathologies depends on a variety of interrelated molecular mechanisms. A key role in modulation of neuron viability belongs to HIF (hypoxia-inducible factor) and NCAM (neural cell adhesion molecules) signaling pathways. Read More

    Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1.
    Cell Biol Int 2017 Sep 6;41(9):1056-1064. Epub 2017 Aug 6.
    Medical-Record Department, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China.
    Colorectal cancer (CRC) is a common human gastrointestinal cancer, and recent studies indicate that circular RNA (circRNA) may regulate cancer development. In this study, we assess the role of circRNA specifically in colorectal cancer. Our quantitative PCR assays demonstrate an upregulation of the circRNA has_circ_0020397 and a downregulation of miR-138 in CRC cells, as well as a negative correlation between these two. Read More

    Runx3 inhibits melanoma cell migration through regulation of cell shape change.
    Cell Biol Int 2017 Sep 27;41(9):1048-1055. Epub 2017 Jul 27.
    The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China.
    The transcription factor Runx3 is a known tumor suppressor gene, and its expression is frequently lost in melanoma. However, the potential contribution of the loss of Runx3 expression to melanoma development and progression remains unclear. In this in vitro study, we demonstrated that ectopic Runx3 re-expression in B16-F10 melanoma cells changed the cell shape from elongated and branched to spread and unbranched, which enhanced stress fiber formation, increased the number of mature and fibrillar focal adhesions, and up-regulated fibronectin expression. Read More

    atz-1 Influences meiosis to maintain germline chromosomal stability in Caenorhabditis elegans.
    Cell Biol Int 2017 Oct 10;41(10):1160-1168. Epub 2017 Aug 10.
    School of Applied and Biomedical Sciences, Federation University, Churchill, Australia.
    Exchange of genetic information during meiosis occurs in all sexually reproducing species to produce haploid gametes from diploid cells. This process involves tight coordination of a meiotic specific cohesin complex, the synaptonemal complex, and DNA damage repair mechanisms. In this study, we describe a putative myosin heavy chain protein orthologous to human myosin 1, F28D1. Read More

    The post-therapeutic effect of rapamycin in mild traumatic brain-injured rats ensuing in the upregulation of autophagy and mitophagy.
    Cell Biol Int 2017 Sep 31;41(9):1039-1047. Epub 2017 Jul 31.
    Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, 310058, China.
    Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Read More

    3D-modeling of carboxyl-terminal phosphorylation of plant αβ-tubulin and its role in kinesin-8/microtubule interaction.
    Cell Biol Int 2017 Jul 7. Epub 2017 Jul 7.
    Department of Genomics and Molecular Biotechnology, Institute of Food Biotechnology and Genomics, Natl. Acad. Sci. of Ukraine, Osipovs'koho St., 2a, 04123, Kyiv, Ukraine.
    The results of computer modeling of plant kinesin-8/αβ-tubulin complexes with such αβ-tubulins' modified amino acid residues as phosphorylated Tyr262 and Tyr107 are reported in this paper. The molecular dynamics of these modified complexes in comparison with the dynamics of non-modified ones suggests that the phosphorylation of both α- and β-tubulins reveals stabilizing effect on the protein structure around the modified residue. It was found also that the phosphorylation of Tyr107 in β-tubulin molecule favors to more advantageous kinesin-8 binding with the phosphorylated microtubule surface in terms of energy. Read More

    Restoration of microRNA-708 sensitizes ovarian cancer cells to cisplatin via IGF2BP1/Akt pathway.
    Cell Biol Int 2017 Oct 17;41(10):1110-1118. Epub 2017 Aug 17.
    Department of Obstetrics and Gynecology, Dezhou People's Hospital, Dezhou, People's Republic of China.
    A previous study has shown that microRNA-708 (miR-708) functions as a metastasis suppressor in ovarian cancer. In this study, we aimed to explore its implication in regulating cisplatin sensitivity in ovarian cancer cells. To this end, ovarian cancer cells were transfected with miR-708-expressing plasmids or vector before treatment with different concentrations of cisplatin for 48 h. Read More

    MDA-MB-231 and 8701BC breast cancer lines promote the migration and invasiveness of ECV304 cells on 2D and 3D type-I collagen matrix.
    Cell Biol Int 2017 Sep;41(9):1030-1038
    Dipartimento STEBICEF, Università di Palermo, viale delle Scienze 90128 Palermo, Sicilia, Italy.
    Tumor angiogenesis is a multiphasic process, having the extracellular matrix remodeling as critical step. Different classes of proteolytic enzymes in matrix digestion/remodeling are involved. The role of lytic enzymes and their activation mode have not been completely elucidated. Read More

    FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.
    Cell Biol Int 2017 Oct 29;41(10):1103-1109. Epub 2017 Aug 29.
    Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 110122, China.
    FAM107B expression was decreased in stomach cancer and many other kinds of cancer. The forced expression of FAM107B in HeLa cells diminished proliferation in response to growth factors, suggesting that FAM107B might play important roles in many types of cancers. But the mechanisms underlying the decreased expression of FAM107B in cancers are not clear, the functional significance needs to be further clarified. Read More

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