662 results match your criteria Cell And Bioscience[Journal]


Correction to: DNA mismatch repair in the context of chromatin.

Cell Biosci 2020 2;10:84. Epub 2020 Jul 2.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.

[This corrects the article DOI: 10.1186/s13578-020-0379-7.]. Read More

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http://dx.doi.org/10.1186/s13578-020-00447-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333259PMC

MicroRNA let-7b inhibits cell proliferation via upregulation of p21 in hepatocellular carcinoma.

Cell Biosci 2020 1;10:83. Epub 2020 Jul 1.

The Second Department of Biliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438 China.

Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumor types and has a high incidence and mortality. Many miRNAs play important roles in the development of HCC. Identification of these miRNAs and their targets is increasingly urgent for a better understandingof miRNA function in both physiological and pathological contexts. Read More

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http://dx.doi.org/10.1186/s13578-020-00443-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329548PMC

An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer.

Cell Biosci 2020 22;10:82. Epub 2020 Jun 22.

Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran.

Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Read More

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http://dx.doi.org/10.1186/s13578-020-00445-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310005PMC

Limited MOMP, ATM, and their roles in carcinogenesis and cancer treatment.

Cell Biosci 2020 18;10:81. Epub 2020 Jun 18.

Department of Dermatology, Duke University Medical Center, Durham, NC USA.

Limited mitochondria outer membrane permeability (MOMP) is a novel biological process where mammalian cells initiate the intrinsic apoptosis pathway with increased mitochondrial permeability but survive. One of the major consequences of limited MOMP is apoptotic endonuclease-induced DNA double strand breaks. Recent studies indicate that these DNA double stand breaks and ensuing activation of DNA damage response factors such as ATM play important but previously underappreciated roles in carcinogenesis and tumor growth. Read More

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http://dx.doi.org/10.1186/s13578-020-00442-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302000PMC

MicroRNA-320d regulates tumor growth and invasion by promoting FoxM1 and predicts poor outcome in gastric cardiac adenocarcinoma.

Cell Biosci 2020 16;10:80. Epub 2020 Jun 16.

The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, No. 263, Kaiyuan Street, Luolong District, Luoyang, 471000 China.

Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. However the effect of miR-320d on gastric cardiac adenocarcinoma (GCA) and the association of miR-320d with its potential gene target FoxM1 remain unclear. Here, we evaluated expression profile of miR-320d and FoxM1 in 60 human GCA tissues and GCA cell lines (OE-19 and SK-GT2). Read More

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http://dx.doi.org/10.1186/s13578-020-00439-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298787PMC

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia.

Cell Biosci 2020 15;10:79. Epub 2020 Jun 15.

Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204 China.

Background: Ischemic stroke poses a severe risk to human health worldwide, and currently, clinical therapies for the disease are limited. Delta opioid receptor (DOR)-mediated neuroprotective effects against ischemia have attracted increasing attention in recent years. Our previous studies revealed that DOR activation by [d-Ala2, d-Leu5] enkephalin (DADLE), a selective DOR agonist, can promote hippocampal neuronal survival on day 3 after ischemia. Read More

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http://dx.doi.org/10.1186/s13578-020-00441-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294676PMC

Identification of hub genes associated with RNAi-induced silencing of XIAP through targeted proteomics approach in MCF7 cells.

Cell Biosci 2020 11;10:78. Epub 2020 Jun 11.

Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Zip Code: 4934174515, Gorgan, Iran.

Background: The X-linked inhibitor of apoptosis protein (XIAP) is the most potent caspase inhibitor of the IAP family in apoptosis pathway. This study aims to identify the molecular targets of XIAP in human breast cancer cells exposed to XIAP siRNA by proteomics screening. The expression of XIAP was reduced in MCF-7 breast cancer cells by siRNA. Read More

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http://dx.doi.org/10.1186/s13578-020-00437-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291505PMC

MicroRNA-7: expression and function in brain physiological and pathological processes.

Cell Biosci 2020 10;10:77. Epub 2020 Jun 10.

School of Medicine, Guizhou University, Guiyang, 550025 Guizhou China.

MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level and play critical roles in regulating physiological function, and are becoming worldwide research hot spot in brain development and diseases. However, the exact value of miRNAs in brain physiological and pathological processes remain to be fully elucidated, which is vital for the application of miRNAs as diagnostic, prognostic, and therapeutic biomarkers for brain diseases. MicroRNA-7 (miR-7), as a highly expressed miRNA molecule in the mammalian brain, is well documented to play a critical role in development of various diseases. Read More

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http://dx.doi.org/10.1186/s13578-020-00436-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288475PMC
June 2020
3.210 Impact Factor

KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis.

Cell Biosci 2020 8;10:76. Epub 2020 Jun 8.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China.

Background: Colorectal cancer (CRC) is the fourth most deadly malignancy throughout the world. Extensive studies have shown that Krüppel-like factors (KLFs) play essential roles in cancer development. However, the function of KLF13 in CRC is unclear. Read More

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http://dx.doi.org/10.1186/s13578-020-00440-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281930PMC

Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review.

Cell Biosci 2020 3;10:75. Epub 2020 Jun 3.

Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia.

Stem cell-based regenerative medicine is a promising approach for tissue reconstruction. However, a large number of cells are needed in a typical clinical study, where conventional monolayer cultures might pose a limitation for scale-up. The purpose of this review was to systematically assess the application of microcarriers in Mesenchymal Stem Cell cultures. Read More

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http://dx.doi.org/10.1186/s13578-020-00438-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271456PMC
June 2020
3.210 Impact Factor

The functions of long non-coding RNAs in neural stem cell proliferation and differentiation.

Cell Biosci 2020 29;10:74. Epub 2020 May 29.

Institute for Translational Medicine, Qingdao University, Qingdao, China.

The capacities for neural stem cells (NSCs) self-renewal with differentiation are need to be precisely regulated for ensuring brain development and homeostasis. Recently, increasing number of studies have highlighted that long non-coding RNAs (lncRNAs) are associated with NSC fate determination during brain development stages. LncRNAs are a class of non-coding RNAs more than 200 nucleotides without protein-coding potential and function as novel critical regulators in multiple biological processes. Read More

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http://dx.doi.org/10.1186/s13578-020-00435-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260844PMC
May 2020
3.210 Impact Factor

Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells.

Cell Biosci 2020 26;10:73. Epub 2020 May 26.

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031 China.

Background: Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment was often associated with poor prognosis and reduced cytotoxic T cell infiltration. These contradictory phenomena suggest that IL-17 may have unique target cells in tumor microenvironment which switch its biological consequences from pro-inflammatory to anti-inflammatory. Read More

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http://dx.doi.org/10.1186/s13578-020-00431-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249370PMC
May 2020
3.210 Impact Factor

Metoprolol alleviates arginine vasopressin-induced cardiomyocyte hypertrophy by upregulating the AKT1-SERCA2 cascade in H9C2 cells.

Cell Biosci 2020 24;10:72. Epub 2020 May 24.

Department of Cardiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038 Shaanxi People's Republic of China.

Background: Arginine vasopressin (AVP) is elevated in patients with heart failure, and the increase in the AVP concentration in plasma is positively correlated with disease severity and mortality. Metoprolol (Met) is a beta blocker that is widely used in the clinic to treat pathological cardiac hypertrophy and to improve heart function. However, the specific mechanism by which Met alleviates AVP-induced pathological cardiac hypertrophy is still unknown. Read More

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http://dx.doi.org/10.1186/s13578-020-00434-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247229PMC

Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection.

Cell Biosci 2020 24;10:70. Epub 2020 May 24.

Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD 21853 USA.

Herpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a permissive non-neuronal cell culture, HSV-1 concludes the entire life cycle in approximately 18-20 h, encoding approximately 90 unique transcriptional units. Read More

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http://dx.doi.org/10.1186/s13578-020-00430-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247163PMC

Emerging functions and clinical applications of exosomes in human oral diseases.

Cell Biosci 2020 24;10:68. Epub 2020 May 24.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fluids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. Read More

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http://dx.doi.org/10.1186/s13578-020-00424-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245751PMC

Perspective of placenta derived mesenchymal stem cells in acute liver failure.

Cell Biosci 2020 24;10:71. Epub 2020 May 24.

1Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Acute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver disease. Since there are problems with liver transplantation including lack of donors, use of immunosuppressive drugs, and high costs of this process, new therapeutic approaches alongside current treatments are needed. Read More

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http://dx.doi.org/10.1186/s13578-020-00433-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245988PMC

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential.

Cell Biosci 2020 24;10:69. Epub 2020 May 24.

1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Furong District, Changsha, Hunan China.

Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secreted by MSCs derived from different sources that contain therapeutic molecules such as RNA and proteins, which is a novel strategy for cell-free therapy. Read More

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http://dx.doi.org/10.1186/s13578-020-00427-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245623PMC

Whole genome-wide chromosome fusion and new gene birth in the genome.

Cell Biosci 2020 20;10:67. Epub 2020 May 20.

1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 People's Republic of China.

Background: Teleost fishes account for over half of extant vertebrate species. A core question in biology is how genomic changes drive phenotypic diversity that relates to the origin of teleost fishes.

Results: Here, we used comparative genomic analyses with chromosome assemblies of diverse lineages of vertebrates and reconstructed an ancestral vertebrate genome, which revealed phylogenomic trajectories in vertebrates. Read More

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http://dx.doi.org/10.1186/s13578-020-00432-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240998PMC

Intestinal homeostasis: a communication between life and death.

Cell Biosci 2020 19;10:66. Epub 2020 May 19.

2Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892 USA.

Organ homeostasis is essential for organ physiology and disease prevention. In adult vertebrates, the intestinal epithelium is maintained through constant cell proliferation in the crypt and apoptosis of differentiated epithelial cells, mainly at the tip of the villus. Based on studies with altered cell proliferation and tissue damage in the adult mouse intestine, we hypothesize that there is a communication between cell proliferation in the crypt and cell death on the villus, likely via cell-cell and cell-ECM (extracellular matrix) interactions, to coordinate the rate of cell proliferation and death, thus ensuring epithelial homeostasis. Read More

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http://dx.doi.org/10.1186/s13578-020-00429-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236522PMC

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell Biosci 2020 14;10:65. Epub 2020 May 14.

1School of Public Health, Qingdao University, Qingdao, China.

Background: Mesenchymal stromal cells (MSCs) are multiple stromal cells existing in various tissues and have already been employed in animal models and clinical trials to treat immune disorders through potent immunosuppressive capacity. Our previous reports have suggested that MSC immunosuppression is not intrinsic but is acquired upon combined inflammatory cytokine treatment. However, the understanding of detailed molecular mechanisms involved in MSC immunomodulation remains incomplete. Read More

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http://dx.doi.org/10.1186/s13578-020-00428-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227316PMC

Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells.

Cell Biosci 2020 13;10:64. Epub 2020 May 13.

1Solid Tumor Research Center, Research Institute on Cellular and Molecular Medicine, Urmia University of Medical Sciences, Shafa St, Ershad Blvd, P.O. BoX: 1138, 57147 Urmia, Iran.

Background: Eukaryotic cells demonstrate two tightly linked vesicular transport systems, comprising intracellular vesicle transport and extracellular vesicle transport system. Intracellular transport vesicles can translocate biomolecules between compartments inside the cell, for example, proteins from the rough endoplasmic reticulum to the Golgi apparatus. Whereas, the secreted vesicles so-called extracellular vesicles facilitate the transport of biomolecules, for example, nucleic acids, proteins and lipids between cells. Read More

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http://dx.doi.org/10.1186/s13578-020-00426-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218515PMC
May 2020
3.210 Impact Factor

Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.

Cell Biosci 2020 12;10:63. Epub 2020 May 12.

1Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814 USA.

Background: Compared to radiation injury alone (RI), radiation injury combined wound (CI) further enhances acute radiation syndrome and subsequently mortality. We previously reported that therapy with Ghrelin, the 28-amino-acid-peptide secreted from the stomach, significantly increased 30-day survival and mitigated hematopoietic death by enhancing and sustaining granulocyte-colony stimulating factor (G-CSF) and keratinocyte chemoattractant (KC) in the blood and bone marrow; increasing circulating white blood cell depletion; inhibiting splenocytopenia; and accelerating skin-wound healing on day 30 after CI. Herein, we aimed to study the efficacy of Ghrelin on intestinal injury at early time points after CI. Read More

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http://dx.doi.org/10.1186/s13578-020-00425-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216502PMC
May 2020
3.210 Impact Factor

Correction to: A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model.

Cell Biosci 2020 9;10:62. Epub 2020 May 9.

1Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 China.

[This corrects the article DOI: 10.1186/s13578-018-0226-2.]. Read More

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http://dx.doi.org/10.1186/s13578-020-00421-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211332PMC

Correction to: Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy‑associated cardiomyopathy.

Cell Biosci 2020 4;10:61. Epub 2020 May 4.

Department of Obstetrics, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, 130021 Jilin People's Republic of China.

[This corrects the article DOI: 10.1186/s13578-019-0348-1.]. Read More

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http://dx.doi.org/10.1186/s13578-020-00419-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199318PMC

Direct activation of tRNA methyltransferase-like 1 (Mettl1) gene by thyroid hormone receptor implicates a role in adult intestinal stem cell development and proliferation during metamorphosis.

Cell Biosci 2020 4;10:60. Epub 2020 May 4.

Section on Molecular Morphogenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 USA.

Background: Thyroid hormone (T3) plays an important role in vertebrate development. Compared to the postembryonic development of uterus-enclosed mammalian embryos, T3-dependent amphibian metamorphosis is advantageous for studying the function of T3 and T3 receptors (TRs) during vertebrate development. The effects of T3 on the metamorphosis of anurans such as is known to be mediated by TRs. Read More

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http://dx.doi.org/10.1186/s13578-020-00423-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197180PMC

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.

Cell Biosci 2020 25;10:59. Epub 2020 Apr 25.

1Institute of Human Genetics, Jena University Hospital, Am Klinikum 1, 07740 Jena, Germany.

Background: The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype. Hence, studies and development of senolytic compounds that induce cell death in senescent cells have recently emerged. Senescent cells are hypothesized to exhibit different upregulated pro-survival/anti-apoptotic networks depending on the senescent inducers. Read More

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http://dx.doi.org/10.1186/s13578-020-00422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183592PMC

Temporal transcriptome change of revealed by invasion.

Cell Biosci 2020 17;10:58. Epub 2020 Apr 17.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, 200025 People's Republic of China.

Background: The freshwater snail is the obligate intermediate host for in China. Transcriptomic examination of snail-schistosome interactions can provide valuable information of host response at physiological and immune levels.

Methods: To investigate -induced changes in gene expression, we utilized high-throughput sequencing to identify transcripts that were differentially expressed between infected snails and their uninfected controls at two key time-point, Day 7 and Day 30 after challenge. Read More

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http://dx.doi.org/10.1186/s13578-020-00420-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165382PMC

BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia.

Cell Biosci 2020 15;10:57. Epub 2020 Apr 15.

1College of Life Sciences, Wuhan University, No. 299 Bayi Road, Wuhan, Hubei 430072 People's Republic of China.

Background: Forced polyploidization is an effective strategy for acute megakaryoblastic leukemia (AMKL) therapy and factors controlling polyploidization are potential targets for drug development. Although bone morphology protein 2-inducible kinase (BMP2K) has been implied to be a potential target for fasudil, a potent polyploidy-inducing compound, the function of BMP2K in megakaryopoiesis and AMKL remains unknown. This study aimed to investigate the role of BMP2K as a novel regulator in megakaryocyte polyploidization and differentiation and its implication in AMKL therapy. Read More

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http://dx.doi.org/10.1186/s13578-020-00418-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161226PMC

Integrated analysis of transcriptomic and metabolomic profiling reveal the p53 associated pathways underlying the response to ionizing radiation in HBE cells.

Cell Biosci 2020 15;10:56. Epub 2020 Apr 15.

Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, 100850 China.

Background: Radiation damage to normal tissues is a serious concern. P53 is a well-known transcription factor which is closely associated with radiation-induced cell damage. Increasing evidence has indicated that regulation of metabolism by p53 represents a reviving mechanism vital to protect cell survival. Read More

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http://dx.doi.org/10.1186/s13578-020-00417-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160934PMC

Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy.

Cell Biosci 2020 6;10:55. Epub 2020 Apr 6.

Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi'an, 710062 China.

Background: In the past 30 years, incidences of non-alcoholic fatty liver disease (NAFLD) has risen by 30%. However, there is still no clear mechanism or accurate method of anticipating liver failure. Here we reveal the phase transitions of liquid crystalline qualities in hepatic lipid droplets (HLDs) as a novel method of anticipating prognosis. Read More

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http://dx.doi.org/10.1186/s13578-020-00414-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137450PMC
April 2020
3.210 Impact Factor

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours.

Cell Biosci 2020 1;10:54. Epub 2020 Apr 1.

3Department of Inspection and Quarantine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318 China.

The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with those of other signalling pathways, the components of the PI3K/AKT/mTOR signalling pathway are complicated. The regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway are important in many human diseases, including ischaemic brain injury, neurodegenerative diseases, and tumours. Read More

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http://dx.doi.org/10.1186/s13578-020-00416-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110906PMC
April 2020
3.210 Impact Factor

Sphingolipids are required for exocyst polarity and exocytic secretion in .

Cell Biosci 2020 30;10:53. Epub 2020 Mar 30.

1Institute of Translational Medicine, China Medical University, Shenyang, 110122 China.

Background: Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic compartments, whether they control exocytosis process is unclear.

Results: Here, we have investigated the role of sphingolipids in exocytosis by reducing the activity of the serine palmitoyl-transferase (SPT), which catalyzes the first step in sphingolipid synthesis in endoplasmic reticulum. Read More

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http://dx.doi.org/10.1186/s13578-020-00406-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106735PMC

A three layered histone epigenetics in breast cancer metastasis.

Cell Biosci 2020 30;10:52. Epub 2020 Mar 30.

Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram, Kerala 695014 India.

Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer cases-the deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Read More

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http://dx.doi.org/10.1186/s13578-020-00415-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106732PMC

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways.

Cell Biosci 2020 30;10:51. Epub 2020 Mar 30.

1Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing of Fndc5. The other beneficial physiological effects of irisin are alleviation of oxidative stress, neuroprotective effects, and anti-inflammatory properties and associated anti-metastatic effects. Read More

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http://dx.doi.org/10.1186/s13578-020-00413-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106581PMC

OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma.

Cell Biosci 2020 30;10:50. Epub 2020 Mar 30.

1Department of Urology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001 Fujian China.

Background: OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in carcinogenesis of various tumors. We aim to investigate the effect and mechanism of OTUB1/FOXM1 on RCC (renal cell carcinoma) progression. Expression levels of OTUB1 in RCC tissues and cell lines were examined by qRT-PCR (quantitative real-time polymerase chain reaction) and immunohistochemistry. Read More

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http://dx.doi.org/10.1186/s13578-020-00408-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106863PMC

BRCA1 and homologous recombination: implications from mouse embryonic development.

Authors:
Yidan Liu Lin-Yu Lu

Cell Biosci 2020 30;10:49. Epub 2020 Mar 30.

1Key Laboratory of Reproductive Genetics (Ministry of Education) and Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

As an important player in DNA damage response, BRCA1 maintains genomic stability and suppresses tumorigenesis by promoting DNA double-strand break (DSB) repair through homologous recombination (HR). Since the cloning of gene, many mutant alleles have been generated in mice. Mice carrying homozygous mutant alleles are embryonic lethal, suggesting that BRCA1's functions are important for embryonic development. Read More

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http://dx.doi.org/10.1186/s13578-020-00412-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106644PMC

-Δ32 biology, gene editing, and warnings for the future of CRISPR-Cas9 as a human and humane gene editing tool.

Authors:
MengMeng Xu

Cell Biosci 2020 30;10:48. Epub 2020 Mar 30.

Department of Pediatrics, Morgan Stanley Children's Hospital, Columbia University, 3959 Broadway, New York, NY 10032 USA.

Background: Biomedical technologies have not just improved human health but also assisted in the creation of human life. Since the first birth of a healthy baby by in vitro fertilization (IVF) 40 years ago, IVF has been the mainstay treatment for couples struggling with infertility. This technology, in addition to increasingly accessible genetic testing, has made it possible for countless couples to have children. Read More

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http://dx.doi.org/10.1186/s13578-020-00410-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106751PMC

The DNA secondary structures at telomeres and genome instability.

Authors:
Jun Tan Li Lan

Cell Biosci 2020 26;10:47. Epub 2020 Mar 26.

1Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129 USA.

Telomeric DNA are TTAGGG tandem repeats, which are susceptible for oxidative DNA damage and hotspot regions for formation of DNA secondary structures such as t-loop, D-loop, G-quadruplexes (G4), and R-loop. In the past two decades, unique DNA or RNA secondary structures at telomeres or some specific regions of genome have become promising therapeutic targets. G-quadruplex and R-loops at telomeres or transcribed regions of genome have been considered as the potential targets for cancer therapy. Read More

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http://dx.doi.org/10.1186/s13578-020-00409-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104500PMC
March 2020
3.210 Impact Factor

Thyroid hormone receptor beta is critical for intestinal remodeling during metamorphosis.

Cell Biosci 2020 27;10:46. Epub 2020 Mar 27.

Section on Molecular Morphogenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 USA.

Background: Thyroid hormone (T3) is critical for development in all vertebrates. The mechanism underlying T3 effect has been difficult to study due to the uterus-enclosed nature of mammalian embryos. Anuran metamorphosis, which is dependent on T3 but independent of maternal influence, is an excellent model to study the roles of T3 and its receptors (TRs) during vertebrate development. Read More

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http://dx.doi.org/10.1186/s13578-020-00411-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099810PMC

Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor.

Cell Biosci 2020 23;10:45. Epub 2020 Mar 23.

Department of Neurology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006 Jiangxi China.

Background: Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate whether botulinum toxin type A (BTX-A) regulates microglial M1/M2 polarization by inhibiting P2X7 expression in a rat model of NP.

Results: The BTX-A administration elevated pain threshold, induced microglial polarization toward the M2 phenotype, and decreased P2X7 protein level in a rat model of NP induced by chronic compression injury (CCI). Read More

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http://dx.doi.org/10.1186/s13578-020-00405-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092425PMC

PIWI-interacting RNAs: new biomarkers for diagnosis and treatment of breast cancer.

Cell Biosci 2020 23;10:44. Epub 2020 Mar 23.

3Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Cancer is one of the most important reasons of mortality in the world. However, there are several therapeutic platforms to treat patients who suffering from cancer common treatments such as surgery, chemotherapy and etc. The current therapeutic approaches are related to some limitations. Read More

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http://dx.doi.org/10.1186/s13578-020-00403-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092456PMC

Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway.

Cell Biosci 2020 20;10:43. Epub 2020 Mar 20.

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan China.

Background: Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to investigate the molecular mechanisms involved in Sirt6 protection against the apoptosis of human intrahepatic biliary epithelial cells (HiBEC) induced by the bile acid glycochenodeoxycholate (GCDC).

Results: Sirt6 was either overexpressed or knocked down in HiBEC, with or without GCDC pretreatment. Read More

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http://dx.doi.org/10.1186/s13578-020-00402-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083051PMC
March 2020
3.210 Impact Factor

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway.

Cell Biosci 2020 17;10:42. Epub 2020 Mar 17.

1Department of Pediatrics, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, ChangshaHunan, 410013 China.

Background: Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating epileptogenesis. We previously found that dynorphins protected against epilepsy via activation of kappa opioid receptor (KOR). Read More

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http://dx.doi.org/10.1186/s13578-020-00387-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079364PMC

HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant.

Cell Biosci 2020 16;10:41. Epub 2020 Mar 16.

Department of Internal Medicine, Division of Medical Oncology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Ratchathewi, Bangkok, 10400 Thailand.

Background: Epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target. Overexpression of EGFR is frequently observed in hepatocellular carcinoma (HCC) and EGFR activation has been proven to be a potential determinant of primary resistance of HCC cells to sorafenib. In our previous study, we found 13 missense mutations in EGFR exon 19-23 from hepatocellular carcinoma (HCC) tissues, but the functions of these mutations have not been determined. Read More

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http://dx.doi.org/10.1186/s13578-020-00407-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076995PMC

SARS-CoV-2 and COVID-19: The most important research questions.

Cell Biosci 2020 16;10:40. Epub 2020 Mar 16.

1School of Biomedical Sciences, The University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis. Read More

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http://dx.doi.org/10.1186/s13578-020-00404-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074995PMC

Fanconi anemia pathway as a prospective target for cancer intervention.

Cell Biosci 2020 16;10:39. Epub 2020 Mar 16.

1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Gautier Building Room 311, 1011 NW 15th Street, Miami, FL 33136 USA.

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a genetic vulnerability for cancer predisposition. The cancer relevance of the FA pathway is further established with the pervasive occurrence of FA gene alterations in somatic cancers and observations of FA pathway activation-associated chemotherapy resistance. Read More

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http://dx.doi.org/10.1186/s13578-020-00401-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075017PMC

Murine hepatoblast-derived liver tumors resembling human combined hepatocellular-cholangiocarcinoma with stem cell features.

Cell Biosci 2020 13;10:38. Epub 2020 Mar 13.

1Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, 3400 Civic Center Drive, PCAM GI 7S, Philadelphia, PA 19104-6145 USA.

Background: Combined hepatocellular-cholangiocarcinoma (CHC) is a primary hepatic malignancy with heterogeneously combined histological features of putative hepatic progenitor cells (HPC) origin. We describe a mouse model that exhibits the heterogenous histological and phenotypic finding similar to human CHC.

Methods: We injected hepatoblasts isolated from p53 C57BL/6 mice into syngeneic wild-type pre-conditioned C57BL/6 mice. Read More

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http://dx.doi.org/10.1186/s13578-020-00395-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071781PMC

The replisome guides nucleosome assembly during DNA replication.

Cell Biosci 2020 12;10:37. Epub 2020 Mar 12.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871 China.

Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses a set of recent findings regarding the role of replisome components contributing to RC nucleosome assembly. Read More

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http://dx.doi.org/10.1186/s13578-020-00398-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066812PMC

Serum IP-10 and IL-17 from Kawasaki disease patients induce calcification-related genes and proteins in human coronary artery smooth muscle cells in vitro.

Cell Biosci 2020 11;10:36. Epub 2020 Mar 11.

2Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD patients, however the mechanism has not been elucidated. Previous studies have found that interferon-γ-inducible protein (IP)-10 and interleukin (IL)-17 can be elevated and may play a role in KD development and coronary artery lesion formation. Read More

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http://dx.doi.org/10.1186/s13578-020-00400-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066751PMC

The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review.

Cell Biosci 2020 11;10:35. Epub 2020 Mar 11.

1Department of Radiation Oncology, University of Arkansas for Medical Sciences, 4301 W. Markham St., #771, Little Rock, AR 72205-7199 USA.

Poly(ADP-ribose) polymerase (PARP) inhibitors represent one of the successful novel approaches to targeted cancer treatment. Indeed, the US Food and Drug Administration (FDA) has recently approved PARP inhibitors for the treatment of breast and ovarian cancers. Despite the proven efficacy of these agents, certain challenges remain with their use. Read More

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http://dx.doi.org/10.1186/s13578-020-00390-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065339PMC