6,983,989 results match your criteria Cell & Tissue Transplantation & Therapy [Journal]

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Endothelial characteristics in healthy endothelial colony forming cells; generating a robust and valid ex vivo model for vascular disease.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department of Internal medicine, division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.

Background: Endothelial colony forming cells (ECFCs) derived from peripheral blood can be used to analyze the pathophysiology of vascular diseases ex vivo. However, heterogeneity is observed between ECFC clones and this variability needs to be understood and standardized for ECFCs to be used as a cell model for applications in vascular studies.

Objective: Determine reference characteristics of healthy control ECFCs to generate a valid ex vivo model for vascular disease. Read More

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http://dx.doi.org/10.1111/jth.14998DOI Listing

Single-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy.

Cancer Commun (Lond) 2020 Jul 12. Epub 2020 Jul 12.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.

Single-cell RNA sequencing (scRNA-seq) is a novel technology that allows transcriptomic analyses of individual cells. During the past decade, scRNA-seq sensitivity, accuracy, and efficiency have improved due to innovations including more sensitive, automated, and cost-effective single-cell isolation methods with higher throughput as well as ongoing technological development of scRNA-seq protocols. Among the variety of current approaches with distinct features, researchers can choose the most suitable method to carry out their research. Read More

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http://dx.doi.org/10.1002/cac2.12078DOI Listing

Advancements in Transplantation Therapy for Diabetes - Pancreas, Islet and Stem Cell.

J Diabetes Investig 2020 Jul 11. Epub 2020 Jul 11.

Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

In the hundred-year history of exogenous insulin therapy for patients with insulin-dependent diabetes mellitus (IDDM), pancreas transplantation and islet transplantation have gained wide acceptance over recent decades. In addition, research and development of human stem cell-derived cell transplantation have accelerated in recent years. Several preclinical approaches using somatic stem cells for the complications of diabetes also have been explored. Read More

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http://dx.doi.org/10.1111/jdi.13358DOI Listing

Antifungal mechanism of Streptomyces ma. FS-4 on fusarium wilt of banana.

J Appl Microbiol 2020 Jul 12. Epub 2020 Jul 12.

Key Laboratory of Tropical Fruit Biology, Ministry of Agriculture, South Subtropical Crop Research Institute, Chinese Academy of Tropical Agricultural Science, 524091, Zhanjiang, China.

Aim: Research on prevention and cure of banana wilt is important to ensure the healthy development of the banana industry. In this study, antifungal mechanism of Streptomyces ma. FS-4 on fusarium wilt of banana was investigated. Read More

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http://dx.doi.org/10.1111/jam.14784DOI Listing

High resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.

FEBS Open Bio 2020 Jul 11. Epub 2020 Jul 11.

Department of Biology and Biochemistry, Claverton Down, University of Bath, Bath, BA2 7AY, UK.

Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding domain that targets neuronal cell membranes (H ), a translocation domain (H ), and a catalytic domain (LC). Here we present high-resolution crystal structures of the binding domains of BoNT subtypes /A5 (H /A5) and /A6 (H /A6). Read More

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http://dx.doi.org/10.1002/2211-5463.12931DOI Listing

Role of O-GlcNAcylation in the Homeostasis of Metabolic Organs and its Potential Links with Diabetes and its Complications.

J Diabetes Investig 2020 Jul 12. Epub 2020 Jul 12.

Division of Diabetology, Endocrinology, and Nephrology, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

Recent studies using genetically-manipulated mouse models have shown the pivotal role of O-GlcNAcylation in the metabolism of multiple organs. The molecular mechanism involves the sensing of glucose flux by the hexosamine biosynthesis pathway, which leads to the adjustment of cellular metabolism to protect against changes in the environment of each organ via O-GlcNAcylation. More recently, not only glucose but also fluxes of amino acids and fatty acids have been reported to induce O-GlcNAcylation, affecting multiple cellular processes. Read More

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http://dx.doi.org/10.1111/jdi.13359DOI Listing

Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction.

FEBS J 2020 Jul 12. Epub 2020 Jul 12.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

The pervasion of three daily meals and snacks is a relatively new introduction to our shared experience, and is coincident with an epidemic rise in obesity and cardiometabolic disorders of overnutrition. The past two decades have yielded convincing evidence regarding the adaptive, protective effects of calorie restriction (CR) and intermittent fasting (IF) against cardiometabolic, neurodegenerative, proteostatic and inflammatory diseases. Yet, durable adherence to intensive lifestyle changes is rarely attainable. Read More

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http://dx.doi.org/10.1111/febs.15482DOI Listing

Cancer-associated mutations in normal human endometrium: Surprise or expected?

Cancer Sci 2020 Jul 12. Epub 2020 Jul 12.

Department of Obstetrics and Gynecology, Shimane University, Faculty of Medicine, 89-1, Enya-Cho, Izumo, Shimane, 693-8501, Japan.

The human endometrium is an essential component in human reproduction that has the unique characteristic of undergoing cyclic regeneration during each menstrual cycle. Vigorous regeneration after shedding may be sustained by stem/progenitor cells, for which molecular markers have not been fully identified. Although clonality analysis using X chromosome inactivation patterns has shown that normal human endometrial glands are composed of a monoclonal cell population, whether clonal expansion is derived from stem/progenitor cells remains unclear. Read More

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http://dx.doi.org/10.1111/cas.14571DOI Listing

Successful kidney transplantation in a patient with pre-existing chronic myeloid leukemia treated with imatinib.

Am J Transplant 2020 Jul 12. Epub 2020 Jul 12.

Department of Nephrology and Hypertension Diseases, Transplantation Medicine and Rheumatology, Ordensklinikum Linz, Krankenhaus Elisabethinen, Linz, Austria.

Active malignancy is an absolute contraindication to kidney transplantation. As for chronic myeloid leukemia (CML), a Philadelphia-chromosome-positive myeloproliferative neoplasm, the introduction of tyrosine kinase inhibitors has transformed CML from a lethal into a manageable chronic disease with a close-to-normal life expectancy. To date it is unknown whether kidney transplantation can be safely performed in patients with pre-existing CML. Read More

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http://dx.doi.org/10.1111/ajt.16194DOI Listing

Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy.

Liver Int 2020 Jul 12. Epub 2020 Jul 12.

Liver Unit, Gastrointestinal Research Group, Department of Medicine, University of Calgary, Calgary, Canada.

Background & Aims: Cirrhotic cardiomyopathy is a recently recognized entity, but detailed cellular and molecular mechanisms remain unclarified. We aimed to elucidate the role of myosin heavy chain isoform shifts and their relation to calcium transients in the contractile kinetics of cirrhotic rats.

Methods: Cirrhosis was induced in male Lewis Brown-Norway rats by bile duct-ligation (BDL). Read More

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http://dx.doi.org/10.1111/liv.14599DOI Listing

Icaritin activates Nrf2/Keap1 signaling to protect neuronal cells from oxidative stress.

Chem Biol Drug Des 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, 276004, PR China.

Our earlier study indicated that icaritin (ICT) protected mice from cerebral ischemic injury by inhibiting oxidative stress, and this study aimed to investigate its mechanism using a H O -treated SH-SY5Y cells model. Cell viability was assessed by cell counting kit 8 (CCK-8). Oxidative stress parameters were detected by flow cytometry, and signaling pathways were analyzed by immunoblotting. Read More

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http://dx.doi.org/10.1111/cbdd.13765DOI Listing

Impact of Covid19 on a tertiary care pediatric oncology and stem cell transplant unit in Riyadh, Saudi Arabia.

Pediatr Blood Cancer 2020 Jul 12:e28560. Epub 2020 Jul 12.

Department of Pediatric Hematology & Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1002/pbc.28560DOI Listing

Strontium Substitution of Gelatin Modified Calcium Hydrogen Phosphates as Porous Hard Tissue Substitutes.

J Biomed Mater Res A 2020 Jul 12. Epub 2020 Jul 12.

Institute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, Dresden, Germany.

Aiming at the generation of a high strontium-containing degradable bone substitute, the exchange of calcium with strontium in gelatin-modified brushite was investigated. The ion substitution showed two mineral groups, the high-calcium containing minerals with a maximum measured molar Ca/Sr ratio of 80%/20% (mass ratio 63%/37%) and the high-strontium containing ones with a maximum measured molar Ca/Sr ratio of 21%/79% (mass ratio 10%/90%). In contrast to the high-strontium mineral phases, a high mass loss was observed for the calcium-based minerals during incubation in cell culture medium (alpha-MEM), but also an increase in strength owing to dissolution and re-precipitation. Read More

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http://dx.doi.org/10.1002/jbm.a.37057DOI Listing

Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma.

FEBS Open Bio 2020 Jul 12. Epub 2020 Jul 12.

Center of Clinical Laboratory, First medical center of Chinese, PLA General Hospital, Beijin, 100853, China.

The identification of non-invasive biomarkers for detection of renal cell carcinoma (RCC) in early-stage patients may help improve disease outcome. Certain long noncoding RNAs (lncRNAs) have been reported to be possible biomarkers for diagnosis and prognosis of cancer. Here, we examined the suitability of the lncRNA LINC00887 as a potential biomarker for RCC, as its expression has been shown to be elevated in RCC tissue versus normal tissue in the Gene Expression Profiling Interactive Analysis (GEPIA) database. Read More

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http://dx.doi.org/10.1002/2211-5463.12930DOI Listing

Randomised phase II study comparing alternating cycles of sunitinib and everolimus versus standard sequential administration in first-line metastatic renal carcinoma (SUNRISES study).

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.

Background: Alternating blockade of vascular endothelial growth factor receptor (VEGFR) and mammalian target of rapamycin (mTOR) pathways could potentially prevent the occurrence of resistance to anti-VEGFR therapy in metastatic renal cell carcinoma (mRCC).

Methods: SUNRISES, a randomised open-label phase II study, investigated the efficacy of alternating cycles of sunitinib and everolimus compared to standard sequential treatment of sunitinib followed by everolimus upon progression. Treatment-naïve patients with clear-cell mRCC were included. Read More

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http://dx.doi.org/10.1111/bju.15165DOI Listing

Low Rate of COVID-19 pneumonia in Kidney Transplant Recipients - A Battle Between Infection and Immune Response?

Transpl Infect Dis 2020 Jul 11:e13406. Epub 2020 Jul 11.

Department of Nephrology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: With COVID-19 pandemic, concerns about kidney transplant recipients are rising. However, the incidence, clinical course, outcome, and predictive factors of disease severity are obscured.

Methods: We describe clinical and laboratory manifestations, radiologic findings, clinical course, and finally outcome of kidney transplant recipients with COVID-19 pneumonia. Read More

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http://dx.doi.org/10.1111/tid.13406DOI Listing

Disseminated Histoplasmosis in a Kidney Transplant Patient.

Transpl Infect Dis 2020 Jul 12:e13405. Epub 2020 Jul 12.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Patients with impaired cell-mediated immunity have a higher risk of developing histoplasmosis; however, histoplasmosis after solid organ transplantation is rare. In Thailand, histoplasmosis cases are sporadic, and most cases are associated with human immunodeficiency virus (HIV) infection. Herein, we report a case of disseminated histoplasmosis in a kidney transplant Thai recipient diagnosed by fungal staining of fungal culture from bronchoalveolar lavage and bone marrow biopsy. Read More

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http://dx.doi.org/10.1111/tid.13405DOI Listing

Interaction of the Xanthomonas effectors XopQ and XopX results in induction of rice immune responses.

Plant J 2020 Jul 12. Epub 2020 Jul 12.

CSIR- Centre for Cellular and Molecular Biology (CSIR-CCMB), 500007, Hyderabad, India.

Xanthomonas oryzae pv. oryzae uses several type III secretion system (T3SS) secreted effectors, namely XopN, XopQ, XopX, and XopZ, to suppress rice immune responses that are induced following treatment with cell wall degrading enzymes. Here we show that a T3SS secreted effector XopX interacts with two of the eight rice 14-3-3 proteins. Read More

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http://dx.doi.org/10.1111/tpj.14924DOI Listing

Primary melanotic tumors of the nervous system: a consecutive case series.

Eur J Neurol 2020 Jul 12. Epub 2020 Jul 12.

Department of Neurology, Yale School of Medicine, New Haven, CT, United States.

Background: Primary melanotic tumors of the nervous system (PMTNS) are thought to be an exceedingly rare group of tumors not captured by tumor registries. We aimed to determine relative incidence, clinical presentation, diagnostic findings, patient management, and outcome.

Methods: We retrospectively searched the database of the Section of Neuro-Oncology, Yale Cancer Center for patients with primary or metastatic melanotic lesions of the nervous system. Read More

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http://dx.doi.org/10.1111/ene.14437DOI Listing

A multi-layered scaffold for regeneration of smooth muscle and connective tissue layers.

J Biomed Mater Res A 2020 Jul 12. Epub 2020 Jul 12.

Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

Tissue regeneration often requires recruitment of different cell types and rebuilding of two or more tissue layers to restore function. Here we describe the creation of a novel multi-layered scaffold with distinct fiber organizations - aligned to unaligned and dense to porous - to template common architectures found in adjacent tissue layers. Electrospun scaffolds were fabricated using a biodegradable, tyrosine-derived terpolymer, yielding densely-packed, aligned fibers that transition into randomly-oriented fibers of increasing diameter and porosity. Read More

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http://dx.doi.org/10.1002/jbm.a.37058DOI Listing

BBX28/BBX29-HY5-BBX30/31 form a feedback loop to fine-tune photomorphogenic development.

Plant J 2020 Jul 12. Epub 2020 Jul 12.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, National Center for Soybean Improvement, College of Agriculture,Nanjing Agricultural University, Nanjing, 210095, China.

Light is one of the key environmental cues controlling photomorphogenic development in plants. A group of B-box (BBX) proteins play critical roles in this developmental process through diverse regulatory mechanisms. In this study, we report that BBX29 acts as a negative regulator of light signaling. Read More

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http://dx.doi.org/10.1111/tpj.14929DOI Listing

Mechanisms ensuring robust repression of the Drosophila female germline stem cell maintenance factor Nanos via posttranscriptional regulation.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

School of Biological Sciences and Technology, Chonnam National University, Gwangju, South Korea.

During oogenesis in the Drosophila ovary, numerous translational regulators promote the self-renewal or differentiation of stem cells. An intriguing question is how these regulators combine to execute translational regulation. Here, we study mechanisms for the posttranscriptional regulation of nos, a critical stem cell self-renewal factor in the Drosophila ovary; specifically, regulators that promote differentiation of the stem cell daughter. Read More

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http://dx.doi.org/10.1096/fj.202000656RDOI Listing

Photodynamic therapy in Dermatology: beyond current indications.

Dermatol Ther 2020 Jul 11. Epub 2020 Jul 11.

Serviço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar e Universitário de Lisboa Norte, Lisboa, Portugal.

Photodynamic therapy (PDT) has long been used in Dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. Read More

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http://dx.doi.org/10.1111/dth.13997DOI Listing

Novel predictive and therapeutic options for better pregnancy outcome in frozen embryo transfer cycles.

Am J Reprod Immunol 2020 Jul 12:e13300. Epub 2020 Jul 12.

Department of Pediatrics, Alpert Medical School of Brown University, Women & Infants Hospital, Providence, RI, USA.

Since 1978, in the first decades of in vitro fertilization (IVF), the use of ovarian hyperstimulation allowed for the development and transfer of multiple embryos. As IVF technology improved, the number of multiple pregnancies increased, which led to gradual reduction in the number of embryos that were transferred. Embryo freezing (vitrification) was recommended to allow subsequent transfer if the fresh cycle was unsuccessful. Read More

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http://dx.doi.org/10.1111/aji.13300DOI Listing

Exploring a peptidomimetic approach of N-cadherin in modulating fibroblast growth factor receptor signaling for corneal endothelial regeneration.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan R.O.C.

Endothelial rejection and a critical shortage of corneal transplants present an unmet medical need in corneal regeneration research area. Although basic fibroblast growth factor (bFGF) is a potent mitogenic factor for corneal ex vivo expansion, it is also a morphogen eliciting unfavorable endothelial-mesenchymal transition (EnMT) of corneal endothelial cells. A pharmacological reagent that retains the beneficial proliferative effect while lacking the EnMT effect of bFGF would be of great potential in corneal regeneration. Read More

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http://dx.doi.org/10.1096/fj.201902525RRDOI Listing

Comparative study of impact of animal source on physical, structural, and biological properties of bone xenograft.

Xenotransplantation 2020 Jul 12:e12628. Epub 2020 Jul 12.

Nova Teb Research Laboratory, Dental Equipment and Biomaterials Incubation Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Due to the unique features of xenografts including large supply from donors, minimal risk of human disease transmission, and the lower cost of preparation and production compared to autografts and allografts, they are considered as attractive alternatives to traditional bone grafts. The animal source accessibility and production process have a direct correlation with the cost and quality of the final product. To evaluate whether the animal source of the bone has any effect on the physicochemical and histological properties of the final xenograft, three deproteinized bone grafts were prepared from sources that are easily available in Iran, including the bovine (DBB), camel (DCB), and ostrich (DOB). Read More

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http://dx.doi.org/10.1111/xen.12628DOI Listing

Enhanced silk yield in transgenic silkworm (Bombyx mori) via ectopic expression of BmGT1-L in the posterior silk gland.

Insect Mol Biol 2020 Jul 12. Epub 2020 Jul 12.

Biological Science Research Center, Southwest University, Chongqing, China.

The silkworm is an economically important insect producing plentiful silk fiber in the silk gland. In this study, we reported a cross-talk between the fat body, silk gland and midgut through glycine-serine biosynthetic pathway in the silkworm. Amino acid sequence and functional domains of glycine transporter gene BmGT1-L were mapped. Read More

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http://dx.doi.org/10.1111/imb.12655DOI Listing

Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Infectious Diseases Clinic, Linyi People's Hospital, Linyi, P.R. China.

Long non-coding RNAs (lncRNAs) have been highlighted as prominent genetic modulators involved in multiple important biological processes of cancer cells, especially in esophageal cancer (EC). We tried to elucidate the potential role of LINC00337 in the progression of EC. Based on TCGA database analysis and Reverse transcription quantitative polymerase chain reaction determination, high expression of LINC00337 and FSCN1 was detected, while miR-145 exhibited a low expression in EC. Read More

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http://dx.doi.org/10.1096/fj.202000470DOI Listing

Neonatal Apneic Phenotype in a Murine Congenital Central Hypoventilation Syndrome Model is Induced Through Non-Cell Autonomous Developmental Mechanisms.

Brain Pathol 2020 Jul 12. Epub 2020 Jul 12.

The Ohio State University College of Medicine, Department of Pathology, Division of Neuropathology, Columbus, United States.

Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor PHOX2B. Some CCHS patients suffer mainly from deficiencies in CO and/or O respiratory chemoreflex, whereas other patients present with full apnea shortly after birth. Our goal was to identify the neuropathological mechanisms of apneic presentations in CCHS. Read More

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http://dx.doi.org/10.1111/bpa.12877DOI Listing

A low protein maternal diet during gestation has negative effects on male fertility markers in rats - A Systematic Review and Meta-analysis.

J Anim Physiol Anim Nutr (Berl) 2020 Jul 12. Epub 2020 Jul 12.

School of Science and Technology, University of New England, Armidale, NSW, Australia.

Research indicates that some adult diseases including reproductive pathologies are programmed in utero during foetal development. In particular, maternal low dietary protein, during the most critical developmental periods of male foetal development, may have a detrimental impact on male fertility through direct and epigenetic mechanisms. The aim of our study was to evaluate the impact of a gestational low protein diet on fertility markers in male offspring in rats through a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1111/jpn.13411DOI Listing

Antifungal activity of extracts and purified saponins from the rhizomes of Chamaecostus cuspidatus against Candida and Trichophyton species.

J Appl Microbiol 2020 Jul 11. Epub 2020 Jul 11.

Universidade Federal do Triângulo Mineiro, Instituto de Ciências Biológicas e Naturais, Uberaba, MG, Brazil.

Aim: To evaluate the antifungal activity of extracts of Chamaecostus cuspidatus against Candida and Trichophyton species.

Methods And Results: Crude ethanol extracts of leaves, stems and rhizomes were prepared and evaluated for antimicrobial activity. Only the rhizomes extract (RE) showed antifungal activity but had no inhibitory effect against bacteria (Staphylococcus aureus and Escherichia coli). Read More

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http://dx.doi.org/10.1111/jam.14783DOI Listing

LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

The tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing radiation. We evaluated the effect of lysophosphatidic acid (LPA) and its analog, Radioprotein-1, on γ-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and m-IC cell monolayers in vitro and mice in vivo. Mice were subjected to either total body irradiation (TBI) or partial body irradiation (PBI-BM5). Read More

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http://dx.doi.org/10.1096/fj.202000544RDOI Listing

Basal cell carcinoma with perineural invasion: a prospective study examining subtype, tumor surface diameter, invasion depth and anatomic site in 3,005 consecutive cases.

J Cutan Pathol 2020 Jul 12. Epub 2020 Jul 12.

The University of New South Wales, Sydney, Australia.

Background: Basal cell carcinoma (BCC) may present with or without perineural invasion (PNI). We reviewed BCC for PNI by subtype, microscopic tumor surface diameter, invasion depth and anatomic site.

Method: Consecutive excisions were prospectively collected in an Australian center 2016-18. Read More

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http://dx.doi.org/10.1111/cup.13808DOI Listing

The effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation.

Perspect Psychiatr Care 2020 Jul 11. Epub 2020 Jul 11.

Department of Family Medicine, Medical Faculty, Istanbul Medipol University, Istanbul, Turkey.

Purpose: Music therapy has been used for relaxation in traditional medicine. This study explored the effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation (HSCT).

Design And Methods: Thirty patients who were hospitalized for bone marrow transplantation were included. Read More

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http://dx.doi.org/10.1111/ppc.12578DOI Listing

Erlotinib for Non-Small Cell Lung Cancer with Leptomeningeal Metastases: A Phase II Study (LOGIK1101).

Oncologist 2020 Jul 12. Epub 2020 Jul 12.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Lessons Learned: This phase II trial evaluated the efficacy of erlotinib for patients with non-small cell lung cancer with leptomeningeal metastasis. The 17 cerebrospinal fluid specimens that were available for epidermal growth factor receptor mutation analysis were all negative for the resistance-conferring T790M mutation. The cytological objective clearance rate was 30. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0640DOI Listing

Relevance of Rosette Patterns in Variants of Papillary Thyroid Carcinoma.

Cytopathology 2020 Jul 12. Epub 2020 Jul 12.

Division of Anatomic Pathology and Histology, Rome, Italy.

Background: The detection of rosette-like clusters (RLC) of follicular cells in thyroid carcinoma has been reported mostly in the columnar cell variant of papillary thyroid carcinoma (CCV-PTC). Despite the fact that diagnosing variants of PTC is no longer encouraged by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the identification of cytomorphological features such as RLC linked with these tumors might help reduce possible misinterpretation in thyroid fine needle aspiration cytology (FNAC). We accordingly investigated the potential correlation of architectural patterns including RLC with PTC variants. Read More

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http://dx.doi.org/10.1111/cyt.12885DOI Listing

Impact of neutropenia evaluated in terms of the D-index on invasive fungal disease while on empiric or preemptive antifungal treatment strategy in the early phase after allogeneic hematopoietic stem cell transplantation.

Transpl Infect Dis 2020 Jul 11:e13409. Epub 2020 Jul 11.

Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.

Background: We retrospectively evaluated the association between the D-index, which reflects both the depth and duration of neutropenia, and proven/probable invasive fungal disease (IFD) early after allogeneic hematopoietic stem cell transplantation (HSCT) at our center (n=394).

Methods: The D-index was defined as the area over the neutrophil curve during neutropenia. The cumulative D-index from the start of neutropenia until the development of infection (c-D-index) was also evaluated as a real-time assessment of neutropenia. Read More

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http://dx.doi.org/10.1111/tid.13409DOI Listing

Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells.

Oral Dis 2020 Jul 12. Epub 2020 Jul 12.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China.

Objective: There were rarely investigations on the effects and molecular mechanisms of oral squamous cell carcinoma (OSCC) cells when treated with isorhamnetin. This article assesses the anticancer effect of isorhamnetin.

Methods And Materials: OSCC cells were treated with or without isorhamnetin. Read More

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http://dx.doi.org/10.1111/odi.13548DOI Listing

Necrotic cell death increases the release of Macrophage migration inhibitory factor (MIF) by monocytes/macrophages.

Immunol Cell Biol 2020 Jul 12. Epub 2020 Jul 12.

Rheumatology Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.

Macrophage migration inhibitory factor is a pleiotropic inflammatory molecule with both cytokine and non-cytokine activity. MIF is constitutively released from multiple cell types via an unconventional secretory pathway that is not well defined. Here, we looked at MIF release from human and mouse monocytes/macrophages in response to different stimuli. Read More

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http://dx.doi.org/10.1111/imcb.12376DOI Listing

Enolase-phosphatase 1 acts as an oncogenic driver in glioma.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China.

Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in l-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. Read More

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http://dx.doi.org/10.1002/jcp.29926DOI Listing

Whole genome sequencing identifies missense mutation in GRM6 as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse.

Equine Vet J 2020 Jul 12. Epub 2020 Jul 12.

Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, California, 95616, USA.

Background: The only known genetic cause of congenital stationary night blindness (CSNB) in horses is a 1378 bp insertion in TRPM1. However, an affected Tennessee Walking Horse was found to have no copies of this variant.

Objectives: To identify the genetic cause for CSNB in an affected Tennessee Walking Horse. Read More

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http://dx.doi.org/10.1111/evj.13318DOI Listing

Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902.

Transfusion 2020 Jul 12. Epub 2020 Jul 12.

Genentech Inc, San Francisco, California.

Background: Extracorporeal photopheresis (ECP) is an immunomodulatory cellular therapy which has been shown to induce a tolerogenic state in patients with acute and chronic graft-vs-host disease. ECOG-ACRIN explored the activity of ECP as a part of a reduced intensity conditioning regimen in two multicenter trials in patients with MDS (E1902) and lymphomas (E1402). While both studies closed before completing accrual, we report results in 23 patients (17 MDS and 6 lymphoma). Read More

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http://dx.doi.org/10.1111/trf.15798DOI Listing

A multicenter evaluation of heterogeneity in cellular therapy processing laboratory procedure times to assess workload capacity.

Transfusion 2020 Jul 12. Epub 2020 Jul 12.

American Red Cross, Biomedical Services Headquarters, Washington, DC, USA.

Background: Growth in size and complexity of clinical hematopoietic progenitor cell (HPC) transplant programs necessitates parallel increases in cellular therapy laboratory (CTL) workload. Typically individually developed, HPC product processing is labor and time intensive. Variation in procedure type and numbers across CTLs complicates direct comparisons, and benchmark data are not readily available. Read More

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http://dx.doi.org/10.1111/trf.15899DOI Listing

Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus.

Histopathology 2020 Jul 11. Epub 2020 Jul 11.

Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.

Aims: This study was performed to elucidate the clinicopathological characteristics, genetic alterations, and therapeutic targets of primary malignant melanoma of the oesophagus (PMME).

Methods: The clinicopathology and molecular pathology of 13 PMME and 10 skin malignant melanoma (SKMM) cases were analysed via next-generation sequencing (NGS) and immunohistochemistry.

Results: Three-year overall survival rate and the median survival time for PMME patients were 23. Read More

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http://dx.doi.org/10.1111/his.14210DOI Listing

Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Research Center, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada.

Cardiomyocyte migration represents a requisite event of cardiogenesis and the regenerative response of the injured adult zebrafish and neonatal rodent heart. The present study tested the hypothesis that the appearance of the intermediate filament protein nestin in neonatal rat ventricular cardiomyocytes (NNVMs) was associated in part with the acquisition of a migratory phenotype. The cotreatment of NNVMs with phorbol 12,13-dibutyrate (PDBu) and the p38α/β mitogen-activated protein kinase inhibitor SB203580 led to the de novo synthesis of nestin. Read More

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http://dx.doi.org/10.1002/jcp.29934DOI Listing

Oxycodone injections not paired with conditioned place preference have little effect on the hippocampal opioid system in female and male rats.

Synapse 2020 Jul 12:e22182. Epub 2020 Jul 12.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, United States.

Oxycodone (Oxy) conditioned place preference (CPP) in Sprague-Dawley rats results in sex-specific alterations in hippocampal opioid circuits in a manner that facilitates opioid-associative learning processes, particularly in females. Here, we examined if Oxy (3mg/kg, I.P. Read More

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http://dx.doi.org/10.1002/syn.22182DOI Listing

FoxO1a mediated cadmium-induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cadmium (Cd), a type of heavy metal that accumulates in the body because of smoking, mediates the toxic effect of smoking in many diseases, such as cardiovascular disease, osteoarthritis, and osteoporosis. However, the toxic effect of Cd on intervertebral disc tissues have not been reported. In the current study, we demonstrated that Cd induced the apoptosis of annulus fibrosus (AF) cells, which contributed to intervertebral disc degeneration (IVDD). Read More

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http://dx.doi.org/10.1002/jcp.29895DOI Listing

Genetic interaction between the non-homologous end joining factors during B and T lymphocyte development: in vivo mouse models.

Scand J Immunol 2020 Jul 12:e12936. Epub 2020 Jul 12.

Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, 7491, Trondheim, Norway.

Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing distinct effector functions of antibody heavy chain constant regions. Read More

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http://dx.doi.org/10.1111/sji.12936DOI Listing

The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions.

Scand J Immunol 2020 Jul 12:e12933. Epub 2020 Jul 12.

Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.

Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Read More

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http://dx.doi.org/10.1111/sji.12933DOI Listing

Metabolic Epilepsies Amenable to Ketogenic Therapies: Indications, Contra-indications and Underlying Mechanisms.

J Inherit Metab Dis 2020 Jul 12. Epub 2020 Jul 12.

Departments of Neurosciences & Pediatrics, University of California San Diego, Rady Children's Hospital, California, USA.

Metabolic epilepsies arise in the context of rare inborn errors of metabolism (IEM), notably Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS), Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency, Pyruvate Dehydrogenase Complex (PDHC) Deficiency, Non-Ketotic Hyperglycinemia, and mitochondrial cytopathies. A common feature of these disorders is impaired bioenergetics, which through incompletely defined mechanisms result in a wide spectrum of neurological symptoms, such as epileptic seizures, developmental delay, and movement disorders. The ketogenic diet (KD) has been successfully utilized to treat such conditions to varying degrees. Read More

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http://dx.doi.org/10.1002/jimd.12283DOI Listing
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