6,608,170 results match your criteria Cell & Tissue Transplantation & Therapy [Journal]

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PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.

Background: Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and the surrounding tumor microenvironment (TME). Loss of the PTEN tumor suppressor gene is observed in 20% to 30% of prostate cancers (PCa) when first detected and the rate increases with PCa progression and advanced disease. Recent findings implicate a role for PTEN in cellular type I interferon response and immunosuppression in PCa. Read More

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http://dx.doi.org/10.1002/pros.23808DOI Listing

Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
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Effect of Homeopathic Medicines on Intestinal Coccidia and Immune Response Cells in Spotted Rose Snapper (Lutjanus guttatus).

Homeopathy 2019 Apr 18. Epub 2019 Apr 18.

Centro de Investigaciones Biológicas del Noroeste S. C. (CIBNOR), La Paz, México.

Background:  Homeopathy has been widely applied in freshwater species but rarely in marine fish. Farm stress destabilises host-pathogen equilibrium, favouring parasites and disease. Coccidian endoparasites cause intestinal infections and cell degeneration. Read More

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http://dx.doi.org/10.1055/s-0039-1681062DOI Listing

Effects of Homeopathic Phosphorus on Encephalitozoon cuniculi-Infected Macrophages In-Vitro.

Homeopathy 2019 Apr 18. Epub 2019 Apr 18.

Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil.

Introduction:   (), a fungus that acts as an intracellular pathogen, causes a marked neurological syndrome in many host species and is a zoonotic concern. Although no well-established treatment for this syndrome is known, previous successful clinical experience using homeopathic phosphorus has been described in which symptom remission with no mortality occurred in 40/42 animals by means of unknown immunological mechanisms. The latter observation was the main motivation for this study. Read More

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http://dx.doi.org/10.1055/s-0039-1678700DOI Listing

Normal Visual Recovery after Optic Neuritis Despite Significant Loss of Retinal Ganglion Cells in Patients with Multiple Sclerosis.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):425-428. Epub 2019 Apr 18.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland.

Background: Optic neuritis (ON) is a frequent manifestation of demyelinating attack in multiple sclerosis (MS). Initial visual loss can vary from minimal to complete. Visual improvement occurs in about 95% of patients, some of them recovering to normal [visual acuity (VA), color vision, visual field (VF)]. Read More

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http://dx.doi.org/10.1055/a-0853-1721DOI Listing

Corneal Endothelial Decompensation after Ocular Chemical Burn: Description of a New Finding.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):371-376. Epub 2019 Apr 18.

Augenklinik, Universitatsspital Basel, Basel, Switzerland.

Background: Ocular chemical burn is an ophthalmological emergency. Therefore, chemical injuries should be promptly addressed in order to initiate the appropriate treatment as soon as possible and optimize the visual prognosis. We present a retrospective study of ten cases with ocular chemical burn including one with superglue and one with a liquid plaster material injury and describe their clinical course. Read More

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http://dx.doi.org/10.1055/a-0857-6538DOI Listing

The Use of Junfeng BFS Water (JBW) in Dry Eye Syndrome.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):366-370. Epub 2019 Apr 18.

Augenklinik, Otto von Guericke Universität Magdeburg, Magdeburg, Germany.

Background And Purpose: Junfeng BFS Water (JBW) is normal drinking water treated by an extremely low frequency electromagnetic field with certain electromagnetic oscillations. This leads to a change in physical water properties, such as an increase in permittivity and an increase in dissolved oxygen. Animal studies show that JBW has certain biological effects, such as improvement in microcirculation, cell hydration, and blood rheology. Read More

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http://dx.doi.org/10.1055/a-0838-4836DOI Listing

A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. II. Abnormal Near Response Cell Activity in the Supraoculomotor Area.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1670-1676

Washington National Primate Research Center, University of Washington, Seattle, Washington, United States.

Purpose: Convergence insufficiency is a very common disorder that can have significant adverse effects on school performance. When reading, children with this disorder often experience diplopia and headaches. We have recently obtained a rhesus monkey with a naturally occurring impairment of vergence eye movements. Read More

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http://dx.doi.org/10.1167/iovs.18-26440DOI Listing

Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats.

Dev Neurosci 2019 Apr 18:1-10. Epub 2019 Apr 18.

Division of Pediatric Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment.

Objectives: To analyze the clinical, radiological, histopathological, and biochemical aspects of kaolin-induced hydrocephalus in an experimental model, both in the acute phase and after shunt treatment, by means of behavioral tests, magnetic resonance imaging (MRI) scans, histopathological studies, and level of inflammatory interleukins in the CSF.

Methods: Seven-day-old Wistar rats were used and subdivided into three subgroups: treated hydrocephalic (n = 24), untreated hydrocephalic (n = 17), and controls (n = 5). Read More

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http://dx.doi.org/10.1159/000497433DOI Listing

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

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https://www.karger.com/Article/FullText/499043
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http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
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Adipokines Regulate the Expression of Tumor-Relevant MicroRNAs.

Obes Facts 2019 Apr 18;12(2):211-225. Epub 2019 Apr 18.

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Increasing prevalence of obesity requires the investigation of respective comorbidities, including tumor diseases like colorectal, renal, post-menopausal breast, prostate cancer, and leukemia. To date, molecular mechanisms of the malignant transformation of these peripheral tissues induced by obesity remain unclear. Adipose tissue secretes factors with hormone-like functions, the adipokines, and is therefore categorized as an endocrine organ. Read More

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http://dx.doi.org/10.1159/000496625DOI Listing

Role of Nodal signalling in testis development and initiation of testicular cancer.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

A Jorgensen, Department of Growth and Reproduction, Rigshospitalet, Kobenhavn, Denmark.

Testicular development from the initially bipotential gonad is a tightly regulated process involving a complex signalling cascade to ensure proper sequential expression of signalling factors and secretion of steroid hormones. Initially, Sertoli cell specification facilitates differentiation of the steroidogenic fetal Leydig cells and establishment of the somatic niche, which is critical in supporting the germ cell population. Impairment of the somatic niche during fetal life may lead to development of male reproductive disorders, including arrest of gonocyte differentiation, which is considered the first step in the testicular cancer pathogenesis. Read More

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http://dx.doi.org/10.1530/REP-18-0641DOI Listing

High soluble CGA levels are associated with poor survival in bladder cancer.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Reis, Institute of Pathology , University of Essen-Duisburg, Essen, Germany.

Recently, a neuroendocrine-like molecular subtype has been discovered in muscle-invasive urothelial bladder cancer (BC). Chromogranin A (CGA) is a widely used tissue and serum marker in neuroendocrine tumors. Our aim was to evaluate serum CGA (sCGA) concentrations and their associations with clinical and follow-up data in BC and renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1530/EC-19-0068DOI Listing

Screening for mutations in selected miRNA genes in hypogonadotropic hypogonadism patients.

Endocr Connect 2019 May;8(5):506-509

Institute of Biomedicine/Physiology, Biomedicum Helsinki and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.

In approximately half of congenital hypogonadotropic hypogonadism (cHH) patients, the genetic cause remains unidentified. Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. A heterozygous variant in MIR200A (rs202051309; general population frequency of 0. Read More

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http://dx.doi.org/10.1530/EC-19-0080DOI Listing

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jun;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

ATC is an aggressive disease with limited therapeutic options due to drug resistance. TRAIL is an attractive anti-cancer therapy that can trigger apoptosis in a cancer cell-selective manner. However, TRAIL resistance is a major clinical obstacle for its use as a therapeutic drug. Read More

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https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
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Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Stem Cell Res 2019 Apr 10;37:101434. Epub 2019 Apr 10.

Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA. Electronic address:

Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine. Increasingly, laboratories are creating their own banks of iPSCs derived from diverse donors. However, there are not yet standardized guidelines for qualifying these cell lines, i. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101434DOI Listing

Multiple distinct O-Mannosylation pathways in eukaryotes.

Curr Opin Struct Biol 2019 Apr 15;56:171-178. Epub 2019 Apr 15.

Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Electronic address:

Protein O-mannosylation (O-Man), originally discovered in yeast five decades ago, is an important post-translational modification (PTM) conserved from bacteria to humans, but not found in plants or nematodes. Until recently, the homologous family of ER-located protein O-mannosyl transferases (PMT1-7 in yeast; POMT1/POMT2 in humans), were the only known enzymes involved in directing O-Man biosynthesis in eukaryotes. However, recent studies demonstrate the existence of multiple distinct O-Man glycosylation pathways indicating that the genetic and biosynthetic regulation of O-Man in eukaryotes is more complex than previously envisioned. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.003DOI Listing

Contamination of a hospital plumbing system by persister cells of a copper-tolerant high-risk clone of Pseudomonas aeruginosa.

Water Res 2019 Apr 10;157:579-586. Epub 2019 Apr 10.

Laboratoire d'Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France; UMR CNRS 6249, Chrono-environnement, Université de Bourgogne Franche-Comté, Besançon, France; Centre de Ressources Biologiques - Filière Microbiologique de Besançon, Centre Hospitalier Régional Universitaire, Besançon, France. Electronic address:

Background: Pseudomonas aeruginosa (PA) is an important opportunistic pathogen that thrives best in the distal elements of plumbing and waste-water systems. Although nosocomial outbreaks of PA have been associated with water sources, the role of the plumbing system of healthcare premises as a reservoir for this pathogen is still unclear.

Materials And Methods: We collected water samples from 12 technical areas, distant from any medical activity, in a teaching hospital in France once a week for 11 weeks. Read More

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http://dx.doi.org/10.1016/j.watres.2019.04.011DOI Listing

In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli.

Comput Biol Chem 2019 Mar 29;80:225-233. Epub 2019 Mar 29.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: The recombinant human truncated Keratinocyte growth factor (Palifermin) is the only FDA approved medicine for the treatment of oral mucositis. The Keratinocyte growth factor is a fairly unstable protein due to its high aggregation propensity and therefore its expression as a secretory protein may results in the production of a protein with more stability, higher solubility, better folding, enhanced biological activity, N-terminal authenticity and simplified downstream processing.

Objective: The aim of this study was in silico evaluation of 31 different secretory signal peptides to determine the best theoretical candidates for the secretory production of recombinant truncated human KGF in E. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.03.003DOI Listing

Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines.

Bioorg Chem 2019 Apr 11;88:102918. Epub 2019 Apr 11.

Department of Chemistry, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway. Electronic address:

The epidermal growth factor receptor represents an important target in cancer therapy, and low molecular weight inhibitors based on quinazolines have reached the marked. Herein we report on a new scaffold, 5-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines, and show that when employing (S)-phenylglycinol as C-4 substituent, potent inhibitors can be made. The two most active inhibitors have suitable druglike properties, were equipotent with Erlotinib in Ba/F3 cell studies, and showed lower cross reactivity than Erlotinib in a panel of 50 kinases. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102918DOI Listing

Vieloplains A-G, seven new guaiane-type sesquiterpenoid dimers from Xylopia vielana.

Bioorg Chem 2019 Apr 10;88:102891. Epub 2019 Apr 10.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; Institute of Interdisciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address:

Seven new guaiane-type sesquiterpene dimers vieloplains A-G, connecting patterns through three different direct CC bonds compounds 1-5 (C-3 to C-3', C-4 to C-1'), compound 6 (C-2 to C-3', C-4 to C-2') and compound 7 (C-2 to C-1', C-4 to C-2') were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOESY analysis, the Cu Kα X-ray crystallographic the experiment circular dichroism (ECD) and the calculated ECD. Among them, only compound 6 showed a considerable cytotoxicity against DU145 cells with IC values of 9. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.065DOI Listing

Sampling and multiplexing in lab-on-paper bioelectroanalytical devices for glucose determination.

Biosens Bioelectron 2019 Apr 5;135:64-70. Epub 2019 Apr 5.

Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, 33006, Oviedo, Spain. Electronic address:

In this work, we present a multiplexed (eight simultaneous measurements) paper-based electrochemical device developed in a very simple way and using low-cost materials, such as paper, carbon ink and multifunctional connector headers. Meanwhile, we have also combined the paper-based electrochemical platform with a glass-fiber strip in order to integrate easily a sampling step. Both approaches, simultaneous measuring and sampling, have been applied to the determination of glucose using bienzymatic biosensors. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.006DOI Listing

Computational approaches to macromolecular interactions in the cell.

Curr Opin Struct Biol 2019 Apr 15;55:59-65. Epub 2019 Apr 15.

Computational Biology Program and Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66045, USA. Electronic address:

Structural modeling of a cell is an evolving strategic direction in computational structural biology. It takes advantage of new powerful modeling techniques, deeper understanding of fundamental principles of molecular structure and assembly, and rapid growth of the amount of structural data generated by experimental techniques. Key modeling approaches to principal types of macromolecular assemblies in a cell already exist. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.012DOI Listing

Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk).

Eur J Med Chem 2019 Mar 26;173:167-183. Epub 2019 Mar 26.

State Key Laboratory of Chemical Oncogenomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, 518055, China. Electronic address:

Interleukin-2-inducible T-cell kinase (Itk) plays an important role in multiple signal transduction pathways in T and mast cells, and is a potential drug target for treating inflammatory diseases, autoimmune diseases, and T cell leukemia/lymphoma. Herein, we describe the discovery of a series of covalent Itk inhibitors based on the 7H-pyrrolo[2,3-d]pyrimidine scaffold. Placing an appropriate substitution group at a hydration site of the ATP binding pocket of Itk and using a saturated heterocyclic ring as a linker to the reactive group were crucial for selectivity. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.055DOI Listing

Principles of progenitor temporal patterning in the developing invertebrate and vertebrate nervous system.

Curr Opin Neurobiol 2019 Apr 15;56:185-193. Epub 2019 Apr 15.

Department of Basic Neurosciences, University of Geneva, Switzerland; Department of Neurology, Geneva University Hospital, Geneva, Switzerland. Electronic address:

During the development of the central nervous system, progenitors successively generate distinct types of neurons which assemble into the circuits that underlie our ability to interact with the environment. Spatial and temporal patterning mechanisms are partially evolutionarily conserved processes that allow generation of neuronal diversity from a limited set of progenitors. Here, we review examples of temporal patterning in neuronal progenitors in the Drosophila ventral nerve cord and in the mammalian cerebral cortex. Read More

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http://dx.doi.org/10.1016/j.conb.2019.03.004DOI Listing

A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks.

Mutat Res 2019 Apr 6;815:10-19. Epub 2019 Apr 6.

Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany. Electronic address:

The classical G-assay is widely used to assess cell-radiosensitivity and cancer phenotype: Cells are exposed to low doses of ionizing-radiation (IR) and collected for cytogenetic- analysis ˜1.5 h later. In this way, chromosome-damage is measured in cells irradiated in G-phase, without retrieving information regarding kinetics of chromosome-break-repair. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2019.04.001DOI Listing

Plant cell division - defining and finding the sweet spot for cell plate insertion.

Authors:
Sabine Müller

Curr Opin Cell Biol 2019 Apr 15;60:9-18. Epub 2019 Apr 15.

Center for Plant Molecular Biology, Auf der Morgenstelle 32, 72076 Tübingen, Germany. Electronic address:

The plant microtubules form unique arrays using acentrosomal microtubule nucleation pathways, yet utilizing evolutionary conserved centrosomal proteins. In cytokinesis, a multi-component cytoskeletal apparatus, the phragmoplast mediates the biosynthesis of the new cell plate by dynamic centrifugal expansion, a process that demands exquisite coordination of microtubule turnover and endomembrane trafficking. At the same time, the phragmoplast is guided to meet with the parental wall at a cortical site that is predefined before mitotic entry and transiently marked by the preprophase band of microtubules. Read More

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http://dx.doi.org/10.1016/j.ceb.2019.03.006DOI Listing

Folding the genome into mitotic chromosomes.

Curr Opin Cell Biol 2019 Apr 15;60:19-26. Epub 2019 Apr 15.

Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan. Electronic address:

How linear DNA molecules are packaged into compact cylindrical chromosomes in preparation for cell division has remained one of the central outstanding questions in cell biology. Condensin is a highly conserved protein complex that universally determines large-scale DNA geometry during mitotic chromosome assembly. A wide range of recently developed approaches, including super resolution microscopy, single molecule imaging, Hi-C analyses and computational modeling, have profoundly changed how we view mitotic chromosomes. Read More

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http://dx.doi.org/10.1016/j.ceb.2019.03.005DOI Listing

Ghrelin signalling within the rat nucleus accumbens and skilled reach foraging.

Psychoneuroendocrinology 2019 Apr 8;106:183-194. Epub 2019 Apr 8.

Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. Electronic address:

Motivation alters behaviour in a complex manner and nucleus accumbens (NAc) shell has been implied as a key structure regulating such behaviour. Recent studies show that acute ghrelin signalling enhances motivation when assessed in a simple motor task. The aim of the present study was to define the role of ghrelin signalling on motivation in a more complex motor behaviour. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530193012
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http://dx.doi.org/10.1016/j.psyneuen.2019.04.008DOI Listing
April 2019
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Ca-induced sarcoplasmic reticulum Ca release in myotubularin-deficient muscle fibers.

Cell Calcium 2019 Apr 10;80:91-100. Epub 2019 Apr 10.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR-5310, INSERM U-1217, Institut NeuroMyoGène, 8 avenue Rockefeller, 69373, Lyon, France. Electronic address:

Skeletal muscle deficiency in the 3-phosphoinositide (PtdInsP) phosphatase myotubularin (MTM1) causes myotubular myopathy which is associated with severe depression of voltage-activated sarcoplasmic reticulum Ca release through ryanodine receptors. In the present study we aimed at further understanding how Ca release is altered in MTM1-deficient muscle fibers, at rest and during activation. While in wild-type muscle fibers, SR Ca release exhibits fast stereotyped kinetics of activation and decay throughout the voltage range of activation, Ca release in MTM1-deficient muscle fibers exhibits slow and unconventional kinetics at intermediate voltages, suggestive of partial loss of the normal control of ryanodine receptor Ca channel activity. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.04.004DOI Listing

Dopamine induces release of calcium from internal stores in layer II lateral entorhinal cortex fan cells.

Cell Calcium 2019 Apr 10;80:103-111. Epub 2019 Apr 10.

Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, H4B 1R6, Canada. Electronic address:

The entorhinal cortex plays an important role in temporal lobe processes including learning and memory, object recognition, and contextual information processing. The alteration of the strength of synaptic inputs to the lateral entorhinal cortex may therefore contribute substantially to sensory and mnemonic functions. The neuromodulatory transmitter dopamine exerts powerful effects on excitatory glutamatergic synaptic transmission in the entorhinal cortex. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.04.003DOI Listing

STIM1 structure-function and downstream signaling pathways.

Cell Calcium 2019 Apr 8;80:101-102. Epub 2019 Apr 8.

Institute of Biophysics, Johannes Kepler University Linz, Life Science Center, Gruberstrasse 40, 4020 Linz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2019.01.004DOI Listing

Steady-state visual evoked potentials reveal enhanced neural responses to illusory surfaces during a concurrent visual attention task.

Cortex 2019 Mar 26;117:217-227. Epub 2019 Mar 26.

The University of Queensland, Queensland Brain Institute, St Lucia, QLD, Australia; The University of Queensland, School of Psychology, St Lucia, QLD, Australia; Canadian Institute for Advanced Research (CIFAR), Toronto, Canada.

Under natural viewing conditions, visual stimuli are often obscured by occluding surfaces. To aid object recognition, the visual system actively reconstructs the missing information, as exemplified in the classic Kanizsa illusion, a phenomenon termed "modal completion". Single-cell recordings in monkeys have shown that neurons in early visual cortex respond to illusory contours, but it has proven difficult to measure the neural correlates of modal completion in humans. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.03.014DOI Listing

Exposure effects of endotoxin-free titanium-based wear particles to human osteoblasts.

J Mech Behav Biomed Mater 2019 Apr 10;95:143-152. Epub 2019 Apr 10.

Department of Physics, UNESP, São Paulo State University, 17033-360, Bauru, SP, Brazil.

Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understand the effects of their exposure to living cells, a consensual opinion has not yet been obtained. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.04.003DOI Listing

Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Int Immunopharmacol 2019 Apr 15;72:204-210. Epub 2019 Apr 15.

Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effects of baicalein on caerulein induced pancreatitis, and to elucidate the putative underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.018DOI Listing

Elucidating the biodegradation mechanism of tributyl phosphate (TBP) by Sphingomonas sp. isolated from TBP-contaminated mine tailings.

Environ Pollut 2019 Apr 3;250:284-291. Epub 2019 Apr 3.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China; Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants, Beijing, 100083, China.

Tributyl phosphate (TBP) is recognised as a global environmental contaminant because of its wide use in floatation reagents, nuclear fuel reprocessing and plasticisers. This contaminant is hardly degraded by hydrolysis in the environment due to its special physicochemical properties. In this study, one TBP-degrading strain was isolated from TBP-contaminated abandoned mine tailings, and 16S rRNA identification revealed that the strain belonged to the genus Sphingomonas. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.127DOI Listing

Characterization of a Dibenzofuran-degrading strain of Pseudomonas aeruginosa, FA-HZ1.

Environ Pollut 2019 Apr 8;250:262-273. Epub 2019 Apr 8.

State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. Electronic address:

Dibenzofuran (DBF) derivatives have caused serious environmental problems, especially those produced by paper pulp bleaching and incineration processes. Prominent for its resilient mutagenicity and toxicity, DBF poses a major challenge to human health. In the present study, a new strain of Pseudomonas aeruginosa, FA-HZ1, with high DBF-degrading activity was isolated and identified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491193032
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http://dx.doi.org/10.1016/j.envpol.2019.04.026DOI Listing
April 2019
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Effects of perfluorooctanoic acid on stem Leydig cell functions in the rat.

Environ Pollut 2019 Apr 9;250:206-215. Epub 2019 Apr 9.

Department of Pediatrics, Peking University First Hospital, No.1 Xi'an Men Street, West District, Beijing, 100034, China; Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. Electronic address:

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are two perfluorinated chemical products widely existing in the environment. Evidence suggested that PFOA might relate to male reproductive dysfunction in rats and humans. PFOA exposure inhibited the function of Leydig cells. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.120DOI Listing

Increasing DNA content for cost-effective oil production in Parachlorella kessleri.

Bioresour Technol 2019 Apr 11;285:121332. Epub 2019 Apr 11.

State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; Biomass Energy Research Center, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

The aim of this work was to study salt stress effects on DNA content and oil production processes integrating harvesting, lipid accumulation and oil extraction. Salt-induced enlargement of Parachlorella kessleri cells, with increasing content of DNA and neutral lipid were found. The 34. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121332DOI Listing

Micro-aeration in anode chamber promotes p-nitrophenol degradation and electricity generation in microbial fuel cell.

Bioresour Technol 2019 Mar 27;285:121291. Epub 2019 Mar 27.

MOE, Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou University, Lanzhou 730000, Gansu, PR China; Key Laboratory for Resources Utilization Technology of Unconventional Water of Gansu Province, Gansu Academy of Membrane Science and Technology, Lanzhou 730020, Gansu, PR China. Electronic address:

Biodegradation of recalcitrant organic compounds in microbial fuel cell (MFC) is limited, due to its strong electron affinity and persisted in anaerobic condition. In this study, Pseudomonas monteilii LZU-3 degraded p-nitrophenol (PNP) and generated current at 100 mg L of PNP in anode MFC with the addition of oxygen. The highest PNP degradation was 4, 37. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.03.130DOI Listing

Optimization of operating conditions of miniaturize single chambered microbial fuel cell using NiWO/graphene oxide modified anode for performance improvement and microbial communities dynamics.

Bioresour Technol 2019 Apr 11;285:121337. Epub 2019 Apr 11.

School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, U.P. 221005, India. Electronic address:

NiWO and graphene oxide (NWG) modified anodic carbon cloth (CC) is used to improve the performance of single chambered microbial fuel cell (SMFC) by statistical optimization of operational parameters. The properties of synthesized NWG nanocomposite on the surface of modified anode are characterized by FTIR, XRD, EDX, TEM and SEM analysis. The optimum level of operational parameters maximize the power density (PD) 1458 mW/m of SMFC having NWG modified anode and observed 8. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121337DOI Listing

Immobilization of recombinant Escherichia coli whole cells harboring xylose reductase and glucose dehydrogenase for xylitol production from xylose mother liquor.

Bioresour Technol 2019 Apr 13;285:121344. Epub 2019 Apr 13.

Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou 310014, PR China.

In this study, recombinant E. coli BL21(DE3)/pCDFDuet-1-XR-GDH harboring xylose reductase (XR) and glucose dehydrogenase (GDH) were immobilized and applied for the production of xylitol from xylose mother liquor (XML). Various immobilization methods were screened and the cross-linking approach with diatomite and polyetherimide as the raw materials and glutaraldehyde as the cross-linking agent was the optimal one, and the recovery activity reached of 80. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121344DOI Listing

Association of wheat chaff derived silica fiber and esophageal cancer in north China.

Ecotoxicol Environ Saf 2019 Apr 15;178:79-85. Epub 2019 Apr 15.

School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China. Electronic address:

Background: Despite decades of research and intervention programs, the epidemic of esophageal squamous cell carcinoma (ESCC) in the Taihang Mountain area of north China has not seen convincing explanation by any risk factor yet and the incidence has not seen a substantial decrease. Based on recently disclosed association of aridity and wheat consumption with esophageal cancer, we revisited the hypothesis of biogenic silica in esophageal cancer development.

Methods: From the archives of the Pathology Department of Heping Hospital, Changzhi Medical College, we selected three pairs of formalin-fixed samples, tumor tissues and distant normal tissues, of three patients operated for ESCC who had no history of workplace exposure to silica dust. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193045
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.031DOI Listing
April 2019
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Evaluation of the genotoxicity of neurotoxic insecticides using the micronucleus test in Tradescantia pallida.

Chemosphere 2019 Apr 12;227:371-380. Epub 2019 Apr 12.

Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, 38900-402, Uberlândia, Minas Gerais, Brazil.

Neonicotinoids and phenylpyrazoles are classes of neurotoxic insecticides which are able to bind at different ligand sites of neural receptors, leading to the deregulation of insect neural activity and hence resulting in death. The misuse or indiscriminate use of these chemicals is directly associated with several toxicological effects in biota and at different trophic levels. Based on this premise, the aim of the present study was to evaluate and compare the genotoxic capacity of different concentrations of thiamethoxam (TMX), acetamiprid (ACP), imidacloprid (IMI) and fipronil (FP) through the Micronucleus Test in Tradescantia pallida (Trad-MCN). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193072
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.073DOI Listing
April 2019
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Combined effects of environmental xeno-estrogens within multi-component mixtures: Comparison of in vitro human- and zebrafish-based estrogenicity bioassays.

Chemosphere 2019 Apr 9;227:334-344. Epub 2019 Apr 9.

Institut National de l'Environnement Industriel et des risques (INERIS), Unité Ecotoxicologie in vitro et in vivo, UMR-I 02 SEBIO, 60550, Verneuil-en-Halatte, France. Electronic address:

Some recent studies showed that in vitro bioassays based on fish or human estrogen receptor (ER) activation may have distinct responses to environmental samples, highlighting the need to better understand bioassay-specific ER response to environmental mixtures. For this purpose, we investigated a 12-compound mixture in two mixture ratios (M1 and M2) on zebrafish (zf) liver cells stably expressing zfERα (ZELHα cells) or zfERβ2 (ZELHβ2 cells) and on human ER-reporter gene (MELN) cells. The mixture included the well-known ER ligands bisphenol A (BPA) and genistein (GEN), and other compounds representatives of a freshwater background contamination. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.060DOI Listing

Photobiomodulation associated to cellular therapy improve wound healing of experimental full thickness burn wounds in rats.

J Photochem Photobiol B 2019 Apr 10;194:174-182. Epub 2019 Apr 10.

Laboratory of Experimental Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Brazil. Electronic address:

Adipose derived stromal vascular fraction (SVF) is a method of cell therapy potentially applicable for treatment of full thickness burns. Here we investigated if the association of photobiomodulation (PBM) with SVF therapy could improve wound healing in experimentally induced full thickness burn wounds in rats compared to the topical agent 2% silver sulfadiazine in a dose-dependent manner. Sixty-six male Wistar rats were divided in 4 groups containing 5 animals each which received the following treatments: 2% sulfadiazine (SD), SVF, SVF plus PBM at 30 mW (SVFL30), and SVF plus PBM at 100 mW (SVFL100). Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.04.003DOI Listing

Molecular cloning and mRNA expression of IFIT5 in tissues of ducklings infected with virulent duck hepatitis A virus type 3.

Res Vet Sci 2019 Apr 8;124:256-262. Epub 2019 Apr 8.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, Heilongjiang Province, PR China; Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of proteins strongly induced downstream of type I interferon signaling. The function of IFITs has been investigated extensively in mammals. IFIT5 is the sole protein in this family found in birds and little information is available about the function of avian IFIT5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183132
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http://dx.doi.org/10.1016/j.rvsc.2019.04.003DOI Listing
April 2019
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Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L.

Virology 2019 Apr 3;532:22-29. Epub 2019 Apr 3.

Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Wilhelm-Weber-Str. 2, University Göttingen, 37073 Göttingen, Germany. Electronic address:

Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we report that GP-mediated entry of retroviral-, rhabdoviral and filoviral particles depends on CatB/CatL activity and that this effect is cell line-independent. Read More

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http://dx.doi.org/10.1016/j.virol.2019.03.020DOI Listing

Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children.

Int J Pediatr Otorhinolaryngol 2019 Apr 11;122:111-116. Epub 2019 Apr 11.

Department of Pediatrics, University Hospital Brno and Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.

Aims: Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children. Identification of signs typical for cholesteatoma and support of retraction theory of cholesteatoma.

Study Design: a prospective study analysing 31 surgically removed retraction pockets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193017
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http://dx.doi.org/10.1016/j.ijporl.2019.04.008DOI Listing
April 2019
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Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer.

Biomaterials 2019 Apr 8;208:83-97. Epub 2019 Apr 8.

Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, USA. Electronic address:

Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.04.005DOI Listing
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