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Asian J Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of General Surgery, Jinling Hospital, Medicine School of Nanjing University, NO 305 East Zhongshan Road, Nanjing, Jiangsu Province, China. Electronic address:

Background: s As a curative surgical procedure for pancreatic neck-body cancer with invasion to celiac artery (CA), the security and efficacy of distal pancreatectomy (DP) with en bloc resection of the celiac artery (DP-CAR) remain controversial. The purpose of this study was to identify the postoperative outcomes of DP-CAR.

Methods: A retrospectively analysis between January 2010 and January2019 was performed in a single center. Read More

Front Immunol 2021 25;12:628375. Epub 2021 May 25.

Cytokine Signaling Unit, Department of Immunology, Institut Pasteur, Paris, France.

Background: Interferon beta (IFN) has been prescribed as a first-line disease-modifying therapy for relapsing-remitting multiple sclerosis (RRMS) for nearly three decades. However, there is still a lack of treatment response markers that correlate with the clinical outcome of patients.

Aim: To determine a combination of cellular and molecular blood signatures associated with the efficacy of IFN treatment using an integrated approach. Read More

Food Res Int 2021 Jul 7;145:110386. Epub 2021 May 7.

Institute of Food Sciences, CNR, Avellino, Italy; E.L.F.I.D, University "Federico II" Napoli, Italy. Electronic address:

Scope: Several studies reported a role of amylase/trypsin-inhibitors (ATIs) of common wheat species in promoting immune reactions. Here, we investigated in celiac disease (CD), the immunogenic properties of ATIs from diploid compared to common hexaploid wheats after an in vitro proteolytic hydrolysis.

Methods And Results: ATIs purified from two lines of diploid Triticum monococcum (TM), Monlis and Norberto-ID331, and from Triticum aestivum (TA), Sagittario, were digested with pepsin-chymotrypsin (PC) enzymes and analyzed using a proteomic approach, and subsequently their immune stimulatory properties were investigated on jejunal biopsies and T-cell lines from CD patients. Read More

PLoS One 2021 10;16(6):e0252984. Epub 2021 Jun 10.

Infectious Diseases Section, Department of Medical Specialties, King Fahad Medical City, Riyadh, Saudi Arabia.

Objectives: Our study aims at comparing the efficacy and safety of IFN-based therapy (lopinavir/ritonavir, ribavirin, and interferon β-1b) vs. favipiravir (FPV) in a cohort of hospitalized patients with non-critical COVID-19.

Methods: Single center observational study comparing IFN-based therapy (interferon β-1b, ribavirin, and lopinavir/ritonavir) vs. Read More

Mol Nutr Food Res 2021 Jun 10:e2100200. Epub 2021 Jun 10.

Department of Chemistry, Organic Chemistry III, Bielefeld University, Universitätsstr. 25, Bielefeld, 33615, Germany.

Scope: Proteolysis-resistant gliadin peptides are intensely investigated in biomedical research related to Celiac Disease and gluten-related disorders. Herein, the first integrated supramolecular investigation of pepsin-digested gliadin peptides, p-gliadin, is presented in combination with its functional behavior in Caco-2 cell line.

Methods And Results: First, we investigated gliadin degradation by pepsin at pH 3, and the physicochemical properties of p-gliadin were compared with gliadin. Read More

Mucosal Immunol 2021 Jun 9. Epub 2021 Jun 9.

K. G. Jebsen Centre for Coeliac Disease Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Mucosal Immunol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain.

Dig Liver Dis 2021 Jun 7. Epub 2021 Jun 7.

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Italy. Electronic address:

Background And Aim: We aimed to describe the socio-demographic, behavioral and clinical profiles of adult patients with newly diagnosed celiac disease (CeD) and their possible association with QoL and psychological symptoms.

Methods: Adults newly diagnosed with CeD and residents in the Veneto region were included. Their sociodemographic characteristics, clinical presentation, mode of diagnosis, duration of symptoms before diagnosis and comorbidities were recorded. Read More

Cureus 2021 May 3;13(5):e14828. Epub 2021 May 3.

Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction Asthma is a clinical syndrome characterized by reversible and recurrent airway obstruction leading to the symptoms of wheezing, cough, shortness of breath, fatigue, and respiratory distress. It is one of the most common lung pathologies worldwide. Its incidence is on the rise in Pakistan, which may be due to overt environmental pollution or improving screening protocols. Read More

Scand J Gastroenterol 2021 Jun 7:1-2. Epub 2021 Jun 7.

Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.

Front Nutr 2021 19;8:647750. Epub 2021 May 19.

Beijing Key Laboratory of Functional Food From Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.

Celiac disease (CD) is a prevalent disorder with autoimmune features. Dietary exposure of wheat gluten (including gliadins and glutenins) to the small intestine activates the gluten-reactive CD4 T cells and controls the disease development. While the human leukocyte antigen (HLA) is the single most important genetic factor of this polygenic disorder, HLA-DQ2 recognition of gluten is the major biological step among patients with CD. Read More

Clin Case Rep 2021 May 28;9(5):e04170. Epub 2021 May 28.

Diabetes & Endocrinology Care Community Physicians Network Indianapolis IN USA.

Implementing a gluten-free diet and switching to the levothyroxine oral solution significantly improved malabsorptive and hypothyroid symptoms in a patient with hypothyroidism, Addison's disease, and celiac disease without the need to increase levothyroxine dosage. Read More

J Nurse Pract 2014 Oct 14;10(9):666-673. Epub 2014 Oct 14.

Division of Special Studies in Symptom Management in the College of Nursing at New York University in New York. Bernadette Capili, PhD, NP-C, is an associate director of the division and an assistant professor of nursing. Michelle Chang, MS, is a research associate at the division. Joyce K. Anastasi, PhD, DrNP, FAAN, is the director of the division, an Independence Foundation endowed professor, and director of the Herbs, Nutraceuticals and Supplements Program.

Gluten-free diets are increasing in popularity among consumers and fueling a global market of gluten-free products. A gluten-free diet is the only treatment for celiac disease (CD). However, many patients are self-reporting and suspecting "gluten sensitivity" after gastrointestinal symptoms, such as bloating, abdominal pain, or diarrhea, resolve on a gluten-free diet without formal evaluation testing for food allergies or CD. Read More

World J Gastroenterol 2021 May;27(20):2603-2614

Takeda Pharmaceuticals International Co., Cambridge, MA 02139, United States.

Background: Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac disease.

Aim: To understand patterns of follow-up and management of patients with celiac disease, and to characterize symptoms and villous atrophy after diagnosis.

Methods: A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac disease. Read More

Hum Antibodies 2021 May 31. Epub 2021 May 31.

Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran.

Background: Celiac disease is a common gastrointestinal autoimmune disorder. Studies have shown that the prevalence of tooth decay is high in patients with celiac disease. This study was performed to evaluate the serology of celiac disease in children with dental caries. Read More

J Pak Med Assoc 2021 May;71(5):1388-1393

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Saudi Arabia.

Objective: To assess the growth pattern of children with coeliac disease after the introduction of a gluten-free diet.

Method: The retrospective study was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, and comprised data from January 2015 to December 2018 of children aged 2-16 years with biopsy-proven coeliac disease. Serial measurements of height-for-age and weight-for-age z-scores were recorded at 0, 4, 8, 12 and 16 months. Read More

An Pediatr (Engl Ed) 2021 Jun 19;94(6):377-384. Epub 2021 May 19.

Servicio de Gastroenterología-Hepatología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, Spain.

Introduction: The following of a strict gluten-free diet (GFD) is essential in the control of coeliac disease. The aim of this study was to determine the adherence to a GFD in coeliac patients and to evaluate the factors that could influence this adherence.

Material And Methods: A descriptive observational study was carried out, in which gluten immunogenic peptides (GIP) were determined in faeces using a semi-quantitative method, and the Coeliac Dietary Adherence Test was completed. Read More

Acta Paediatr 2021 Jun 3. Epub 2021 Jun 3.

Department of Paediatrics, Tergooi Hospital, Blaricum, The Netherlands.

Aim: Dutch national guidelines on follow-up of paediatric celiac disease (CD) are available. The primary aim was to evaluate guideline adherence by paediatricians during follow-up. The secondary aim was to determine the clinical relevance and diagnostic yield of routine laboratory tests suggested by these guidelines. Read More

Ital J Pediatr 2021 Jun 2;47(1):127. Epub 2021 Jun 2.

Department of Woman, Child and General and Specialized Surgery, University of the Study of Campania "Luigi Vanvitelli", Naples, Italy.

Background: Type 1 diabetes mellitus could be associated with other autoimmune diseases, such as autoimmune thyroid disease, celiac disease, but the association with Familial Mediterranean Fever is rare, we describe a case of a boy with type 1 Diabetes Mellitus associated with Familial Mediterranean Fever (FMF).

Case Presentation: A 13 year old boy already suffering from Diabetes Mellitus type 1 since the age of 4 years, came to our attention because of periodic fever associated with abdominal pain, chest pain and arthralgia. The fever appeared every 15-30 days with peaks that reached 40 °C and lasted 24-48 h. Read More

Medicina (Kaunas) 2021 May 24;57(6). Epub 2021 May 24.

Clinical and Research Laboratory (LACIUS, URS), Department of Chemical, Biological, and Agricultural Sciences (DC-QB), Division of Sciences and Engineering, University of Sonora, Navojoa 85880, Mexico.

Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by the absence of celiac disease and wheat allergy in patients that trigger reproducible symptomatic responses to gluten-containing foods consumption. Due to the lack of sensitive and reproducible biomarkers for NCGS diagnosis, placebo-controlled gluten challenges must be carried out for its diagnosis. The gluten challenges can be either double- or single-blind, for research or clinical practice purposes, respectively. Read More

Nutrients 2021 May 29;13(6). Epub 2021 May 29.

Department of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, Poland.

Access to a registered dietitian experienced in celiac disease (CD) is still limited, and consultation when available focuses primarily on the elimination of gluten from the diet. Thus, the aim of this study was to evaluate the nutritional value of a gluten-free diet (GFD) in adult CD patients before, and one year after, the standard dietary education. The study included 72 CD patients on a GFD and 30 healthy controls. Read More

Nutrients 2021 May 27;13(6). Epub 2021 May 27.

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7810000, Chile.

The COVID-19 pandemic has been present for many months, influencing diets such as the gluten-free diet (GFD), which implies daily challenges even in non-pandemic conditions. Persons following the GFD were invited to answer online ad hoc and validated questionnaires characterizing self-perceptions of the pandemic, current clinical condition, dietary characteristics, adherence to GFD, anxiety, and depression. Of 331 participants, 87% experienced shortage and higher cost of food and 14. Read More

Life (Basel) 2021 May 14;11(5). Epub 2021 May 14.

DIMEC, University of Bologna, 40138 Bologna, Italy.

Introduction: A healthy diet is characterized by a variety of food and a balanced energy intake, which should accompany every human being since early childhood. Unfortunately, excessive consumption of protein, fat, and lately sugar are very common in developed countries. Sugar intakes are not easily quantifiable and comparable among subjects. Read More

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.

We aimed to assess the influence of the Mediterranean Diet adherence and physical activity (PA) on body composition, with a particular focus on bone health, in young patients with celiac disease (CD). The CD group ( = 59) included children with CD with a long (>18 months, = 41) or recent (<18 months, = 18) adherence to a gluten-free diet (GFD). The non-celiac group ( = 40) included non-celiac children. Read More

Nutrients 2021 May 17;13(5). Epub 2021 May 17.

R&D Department, Laboratori Baldacci SpA, 56121 Pisa, Italy.

The iron absorption process developsmainly in the proximal duodenum. This portion of the intestine is typically destroyed in celiac disease (CD), resulting in a reduction in absorption of iron and subsequent iron deficiency anemia (IDA). In fact, the most frequent extra-intestinal manifestation (EIM) of CD is IDA, with a prevalence between 12 and 82% (in relation with the various reports) in patients with new CD diagnosis. Read More

Nutrients 2021 May 22;13(6). Epub 2021 May 22.

Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, 02-091 Warsaw, Poland.

A gluten-free diet provides relief from symptoms for patients with celiac disease, although there is still a risk of nutritional deficiencies. These patients can potentially consume an excessive amount of fat and insufficient amounts of fiber, iron, vitamin D, and calcium. This study aimed to assess the knowledge of medical students and healthcare professionals in Poland regarding nutritional deficiencies and the prevention of such deficiencies in patients with celiac disease who are on a gluten-free diet. Read More

Nutrients 2021 May 12;13(5). Epub 2021 May 12.

Department of Pharmaceutical and Health Sciences, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925 Alcorcón, Spain.

The only available treatment for celiac disease is life-long gluten exclusion. We conducted a cross-sectional age- and gender-matched study in 64 celiac adults on a long-term (>1 year) gluten-free diet and 74 non-celiac volunteers from Spain, using dietary, anthropometric, and biochemical parameters, as well as assessing bone mineral density and physical activity. Celiac adults had deficient intake (below 2/3 of the recommended intake) for folates, vitamin E, and iodine and low intake of calcium (below 80% of the recommended intake). Read More

Vaccines (Basel) 2021 May 16;9(5). Epub 2021 May 16.

Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20214 Milan, Italy.

(1) Background: COVID-19 vaccination campaigns offer the best hope of controlling the pandemic. However, the fast production of COVID-19 vaccines has caused concern among the general public regarding their safety and efficacy. In particular, patients with chronic illnesses, such as celiac disease (CD), may be more fearful. Read More

Nutrients 2021 May 9;13(5). Epub 2021 May 9.

Department of Nutrition, School of Health Sciences, University of Brasilia, 70910-900 Brasilia, Brazil.

Since the end of 2019, the world has been facing an unpredicted COVID-19 pandemic with consequences for the economy, environment, society, and health. The COVID-19 pandemic has increased the risk of death, bringing unbearable psychological pressure upon people worldwide. For celiac patients, the pandemic may represent an additional burden concerning the inherent aspects of celiac disease (CD) that compromise these individuals' quality of life (QoL). Read More

Medicina (Kaunas) 2021 May 11;57(5). Epub 2021 May 11.

Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznań University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznań, Poland.

Celiac disease (CD) is widely perceived as a childhood disorder. However, it has been demonstrated that 19-34% of new CD cases are diagnosed in patients over 60 years of age and lack the typical presentation. A 76-year-old female was admitted to the clinic due to a recurrent fever that had lasted over a year accompanied by progressive weakness, weight loss of about 10 kg, dehydration, and malnutrition. Read More