25,378 results match your criteria Celiac Sprue


Template-based peptide modeling for celiac risk assessment of newly expressed proteins in GM crops.

Regul Toxicol Pharmacol 2020 Jun 30:104715. Epub 2020 Jun 30.

Corteva Agriscience™, United States.

Newly expressed proteins in genetically modified (GM) crops are subject to celiac disease risk assessment according to EFSA guidelines. Amino acid identity matches between short peptides (9aa) and known celiac restricted epitopes are required to be further evaluated through peptide modeling; however, validated methods and criteria are not yet available. In this investigation, several structures of HLA-DQ2. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104715DOI Listing

Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century.

Am J Gastroenterol 2020 Jul;115(7):1117-1124

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Introduction: We assessed whether celiac disease-associated mortality is increased in Finland among patients diagnosed in the 21st century, given recent improvements in diagnostic and treatment facilities.

Methods: Biopsy-proven patients with celiac disease (Marsh III) and dermatitis herpetiformis aged 20-79 years (median 50 years) diagnosed 2005-2014 (n = 12,803) were identified from the national dietary grant registry. Dates and causes of death were obtained from Statistics Finland. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000665DOI Listing

The Gluten-Free Family Ripple Effect: The Tides that Bond and the Tides that Divide.

Dig Dis Sci 2020 Jul 2. Epub 2020 Jul 2.

Harvard Celiac Research Program, Boston Children's Hospital, Boston, MA, 0211, USA.

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http://dx.doi.org/10.1007/s10620-020-06428-7DOI Listing

Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes.

Acta Diabetol 2020 Jul 2. Epub 2020 Jul 2.

Diabetes Research Institute, IRCCS San Raffaele Hospital, 20132, Milan, Italy.

Aims: A higher SGLT1 and GLUT2 gene expression was shown in the intestine of subjects with type 2 diabetes, while no data have been reported in type 1 diabetes (T1D). The purpose of our study was to evaluate the expression of glucose transporters in duodenal mucosa of subjects with T1D, compared to healthy controls (CTRL) and to patients with celiac disease (CD), as gut inflammatory disease control group.

Materials And Methods: Gene expression of GLUT1, GLUT2, SGLT1 and SGLT2 was quantified on duodenal mucosa biopsies of subjects with T1D (n = 19), CD (n = 16), T1D and CD (n = 6) and CTRL (n = 12), recruited at San Raffaele Hospital (Milan, Italy), between 2009 and 2018. Read More

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http://dx.doi.org/10.1007/s00592-020-01558-wDOI Listing

Haemophagocytic lymphohistiocytosis after heart transplantation: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Department of Transplant Institute, Sahlgrenska University Hospital, SE-413 25, Gothenburg, Sweden.

Background: Haemophagocytic lymphohistiocytosis (HLH) is an uncommon but serious systemic inflammatory response with high mortality rates. It can be triggered by malignancy or infectious agents, often in the context of immunosuppression. Literature covering HLH in heart transplantation (HTx) is scarce. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319853PMC

Celiac autoantibody positivity in relation to clinical characteristics in children with type 1 diabetes.

J Clin Transl Res 2020 Apr 19;5(3):91-95. Epub 2020 Feb 19.

University Diabetes Center, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia.

Background: Type 1 diabetes is an autoimmune disorder with a high risk of celiac disease (CD).

Aim: This study aimed to determine the celiac autoantibody status and the clinical characteristics among children with type 1 diabetes and autoantibody positivity for CD compared to those without serological evidence of CD.

Materials And Methods: In this cross-sectional study, 240 children with type 1 diabetes underwent serological screening CD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326273PMC

A Ligamentous Agony: Median Arcuate Ligament Syndrome as an Under-Recognized Cause of Abdominal Pain.

Cureus 2020 Jun 27;12(6):e8865. Epub 2020 Jun 27.

Internal Medicine, Rochester General Hospital, Rochester, USA.

Median arcuate ligament (MAL) syndrome (MALS) is a rare clinical entity characterized by chronic abdominal pain resulting from compression of the celiac artery by the MAL. We present a case of MALS with imaging evidence of anterior compression of the celiac artery on expiration, which was relieved on inspiration. A 33-year-old woman presented with intermittent upper abdominal pain since three months. Read More

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http://dx.doi.org/10.7759/cureus.8865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325387PMC

Deciphering short stature in children.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):69-79. Epub 2020 Jun 30.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Short stature is a common reason for referral to pediatric endocrinologists. Multiple factors, including genetic, prenatal, postnatal, and local environmental factors, can impair growth. The majority of children with short stature, which can be defined as a height less than 2 standard deviation score below the mean, are healthy. Read More

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http://dx.doi.org/10.6065/apem.2040064.032DOI Listing

Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients.

Infect Drug Resist 2020 24;13:1961-1970. Epub 2020 Jun 24.

Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Background: Extended-spectrum ß-lactamase (ESBL)-producing and are the most common uropathogens causing UTI (urinary tract infection) in type 2 diabetes mellitus (T2DM). Circulatory inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are usually dysregulated during UTI. However, the differential regulation of these inflammatory signatures during and UTI in T2DM has not been determined. Read More

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http://dx.doi.org/10.2147/IDR.S251966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323571PMC

mTOR sustains inflammatory response in celiac disease.

Sci Rep 2020 Jul 1;10(1):10798. Epub 2020 Jul 1.

Department of Systems Medicine, University of "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.

Celiac disease (CD) is an enteropathy triggered by the ingestion of gluten proteins in genetically predisposed individuals and characterized by excessive activation of effector immune cells and enhanced production of inflammatory cytokines. However, factors/mechanisms that amplify the ongoing mucosal inflammation in CD are not fully understood. In this study, we assessed whether mammalian target of Rapamycin (mTOR), a pathway that combines intra- and extra-cellular signals and acts as a central regulator for the metabolism, growth, and function of immune and non-immune cells, sustains CD-associated immune response. Read More

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http://dx.doi.org/10.1038/s41598-020-67889-4DOI Listing

[Analysis of the leading pathogenetic factors of dental caries in children with celiac disease].

Stomatologiia (Mosk) 2020 ;99(3):71-73

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The Aim: To identify the leading pathogenetic factors of dental caries in children with celiac disease.

Material And Methods: The study included 48 children with a confirmed diagnosis of celiac disease at the age of 8-16 years. All the children were examined by a dentist, the oral cavity was sanitized, recommendations for oral care were given. Read More

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http://dx.doi.org/10.17116/stomat20209903171DOI Listing

Living with Gluten and Other Food Intolerances: Self-Reported Diagnoses and Management.

Nutrients 2020 Jun 26;12(6). Epub 2020 Jun 26.

Division of Sciences and Engineering, Department of Chemical, Biological and Agricultural Sciences, Clinical and Research Laboratory (LACIUS, URS), University of Sonora, Navojoa, Sonora 85880, Mexico.

People suffering from a food intolerance (FI) tend to initiate restrictive diets such as a gluten-free diet (GFD), to alleviate their symptoms. To learn about how people live with these problems in daily life (independent of their medical diagnoses), 1203 participants answered a previously validated questionnaire and were divided into: G1 (those self-reporting symptoms after gluten consumption) and G2 (those informing no discomfort after gluten consumption). Self-reported clinical characteristics, diagnoses and diets followed were registered. Read More

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http://dx.doi.org/10.3390/nu12061892DOI Listing

Prevalence of auto-antibodies and autoimmune disorders in patients with celiac disease.

Scand J Gastroenterol 2020 Jun 30. Epub 2020 Jun 30.

All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1080/00365521.2020.1785544DOI Listing

Nutritional management of celiac crisis in an elderly adult: A case report of the rare presentation of celiac disease in a 75-y-old woman.

Nutrition 2020 May 19;79-80:110858. Epub 2020 May 19.

Unit of Dietetic and Clinical Nutrition, University Hospital Maggiore della Carità, Novara, Italy.

In adults, a very uncommon presentation of celiac disease (CD) is a celiac crisis, a life-threatening and severe form of the disease having a dramatic onset with diarrhea and metabolic acidosis with electrolyte and fluid imbalance. Treatment of celiac crisis requires a gluten-free diet; however, the risk for refeeding syndrome (RFS) should be considered in patients showing marked malabsorption symptoms and important unintentional weight loss. Therefore, to avoid metabolic and potentially fatal complications of re-nutrition, nutritional management is crucial for a safe recovery after a celiac crisis. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110858DOI Listing

[Chronic pancreatitis with IBS-like syndrome: approach to therapy].

Ter Arkh 2020 Apr 27;92(2):61-66. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.

Materials And Methods: 312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000518DOI Listing

The Epidemiology of Celiac Disease in the General Population and High-Risk Groups in Arab Countries: A Systematic Review.

Biomed Res Int 2020 3;2020:6865917. Epub 2020 Jun 3.

King Abdulaziz Medical City, National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background And Aims: Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns.

Methods: An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. Read More

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http://dx.doi.org/10.1155/2020/6865917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292982PMC

Causal Relationship between Celiac Stenosis and Pancreaticoduodenal Artery Aneurysm: Interpretation by Simulation Using an Electric Circuit.

Biomed Res Int 2020 8;2020:2738726. Epub 2020 Jun 8.

Department of Surgery, Inha University School of Medicine, Incheon 22332, Republic of Korea.

Pancreaticoduodenal artery (PDA) aneurysm and celiac artery (CA) stenosis are rare diseases in themselves. Interestingly, however, there are more cases documented in the literature in which these two disease entities occurred together than could be coincidental, and CA stenosis has been suggested as the provocative condition in developing PDA aneurysm. This study is aimed at examining the causal relationship between CA stenosis and PDA aneurysm by simulating the splanchnic circulation with an electric circuit. Read More

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http://dx.doi.org/10.1155/2020/2738726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298276PMC

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.

Genome Biol 2020 Jun 29;21(1):153. Epub 2020 Jun 29.

Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, NJ, 07110, USA.

Background: Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cells, remain to be clarified.

Results: We perform whole genome methyl-seq on diverse normal cells and tissues and three cancer types. Read More

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http://dx.doi.org/10.1186/s13059-020-02059-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322865PMC

Islet, thyroid and transglutaminase antibodies in adult Bulgarian patients with type 1 diabetes.

Endocrine 2020 Jun 27. Epub 2020 Jun 27.

Department of Endocrinology, Division of Diabetology, Medical University Sofia, Sofia, Bulgaria.

Aim: The aim of the study was to assess the prevalence and relationship of islet antibodies and autoantibodies of the most common associated autoimmune diseases-autoimmune thyroid disease (AITD) and celiac disease, in adult Bulgarian patients with type 1 diabetes of short duration.

Material And Methods: 160 type 1 diabetes patients, of mean age 36.3 ± 10. Read More

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http://dx.doi.org/10.1007/s12020-020-02395-1DOI Listing

Celiac disease does not influence markers of ovarian reserve in adolescent girls.

Arch Gynecol Obstet 2020 Jun 27. Epub 2020 Jun 27.

Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Purpose: The aim of the study was to determine whether celiac disease affects ovarian reserve assessed by antral follicle counting, ovarian volume, and anti-müllerian hormone in adolescent patients.

Methods: This case-control multicenter trial was performed from January 1, 2017 to May 31, 2018 and included 45 girls. On days 2-5 of the menstrual cycle, measurements of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin, and anti-müllerian hormone were performed. Read More

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http://dx.doi.org/10.1007/s00404-020-05666-4DOI Listing
June 2020
1.279 Impact Factor

Ultrasound-assisted fabrication of gluten-free dough for automatic producing dumplings.

Ultrason Sonochem 2020 May 30;68:105198. Epub 2020 May 30.

ITMO University, St. Petersburg, Lomonosova St. 9, 192007, Russia.

Nowadays celiac disease is becoming more common. It is the autonomic genetic disease that is accompanied by damage to the intestines due to a reaction to eating some proteins. People who are suffering from celiac disease cannot eat food containing gluten, including dough made from gluten-containing seeds. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105198DOI Listing

The Utility of IgA-Based Serologic Markers in Diagnosing Celiac Disease in Children 24 Months of Age or Younger.

J Pediatr 2020 Jun 24. Epub 2020 Jun 24.

Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Division of Pediatric Gastroenterology & Hepatology, Rochester, MN.

Current screening guidelines in North America for celiac disease recommend additional IgG based testing for younger children. Our multicenter retrospective study showed that the anti-tissue transglutaminase IgA antibody test should be the recommended initial test in all children, including those ≤24 months of age. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.04.009DOI Listing

Spanish multicenter study of surgical resection of pancreatic tumors infiltrating the celiac axis: does the type of pancreatectomy affect results?

Clin Transl Oncol 2020 Jun 26. Epub 2020 Jun 26.

Department of Surgery, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Background: Pancreatectomy plus celiac axis resection (CAR) is performed in patients with locally advanced pancreatic cancer. The morbidity rates are high, and no survival benefit has been confirmed. It is not known at present whether it is the type of pancreatectomy, or CAR itself, that is the reason for the high complication rates. Read More

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http://dx.doi.org/10.1007/s12094-020-02423-6DOI Listing

Understanding human gut diseases at single-cell resolution.

Hum Mol Genet 2020 Jun 26. Epub 2020 Jun 26.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.

Our understanding of gut functioning and pathophysiology has grown considerably in the past decades, and advancing technologies enable us to deepen this understanding. Single-cell RNA sequencing (scRNA-seq) has opened a new realm of cellular diversity and transcriptional variation in the human gut at a high, single-cell resolution. ScRNA-seq has pushed the science of the digestive system forward by characterizing the function of distinct cell types within complex intestinal cellular environments, by illuminating the heterogeneity within specific cell populations, and by identifying novel cell types in the human gut that could contribute to a variety of intestinal diseases. Read More

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http://dx.doi.org/10.1093/hmg/ddaa130DOI Listing

Distal Pancreatectomy with Celiac Axis Resection (Modified Appleby Procedure) and Arterial Reconstruction for Locally Advanced Pancreatic Adenocarcinoma After FOLFIRINOX Chemotherapy and Chemoradiation Therapy.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgical Oncology, Institut du Cancer de Montpellier (ICM), Montpellier, France.

Background: Resectability of pancreatic carcinoma (PC) is directly linked to vascular extension (Tempero MA et al. in J Natl Compr Canc Netw 15(8):1028-1061, 2017. https://doi. Read More

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http://dx.doi.org/10.1245/s10434-020-08740-yDOI Listing

Caries among adult patients with controlled celiac disease: A cross-sectional study.

Spec Care Dentist 2020 Jun 25. Epub 2020 Jun 25.

Faculty of Dentistry, Health Sciences Center, Faculty of Dentistry, Health Sciences Center, Kuwait University, Jabriya, Kuwait.

Introduction: Celiac disease (CD) is one of the most common chronic gastrointestinal disorders in the world. Currently, the literature about the dental profiles of patients with celiac disease is sparse and no studies have reported on the oral conditions and caries status of CD patients in Kuwait.

Objective: This study investigated the association between CD and caries experience. Read More

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http://dx.doi.org/10.1111/scd.12491DOI Listing

[THE GUT FEELING OF THE EYES: GUT-EYE AXIS].

Harefuah 2020 Jun;159(6):455-457

Clalit Health Services, Sharon-Shomron district, Israel.

Introduction: In intestinal diseases there are ophthalmological abnormalities. In celiac disease, for example, the eyes' pathologies are expressed by motoric, neurological, inflammatory, autoimmune, vision sharpness, dryness, redness, conjunctivitis and cataract tendency etc. It appears that intestinal luminal components and processes can irradiate to peripheral organs, including to the eyes, inducing functional abnormalities in this target organ. Read More

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[THE INFLUENCE OF GLUTEN ON THE SHARPNESS OF VISION].

Harefuah 2020 Jun;159(6):452-454

Surgical Department (pensioner), Hasharon Hospital, Rabin Medical Center.

Introduction: An eighty five old male was diagnosed with celiac disease. Six months before the diagnosis he complained of difficulties in his sight. In an optimetrical examination a decline in sharpness of sight was found: Right (R) - 6/19, Left (L) - 6/12. Read More

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Change in Patient MELD-Na and Albumin Level From the Time of Celiac Disease Diagnosis to Six Months Later After Gluten-Free Diet.

Cureus 2020 May 22;12(5):e8237. Epub 2020 May 22.

Biostatistics, Geisinger Medical Center, Danville, USA.

Background & aims Celiac disease (CD) is a multisystem disorder triggered by dietary gluten in genetically predisposed individuals that may affect any organ system, including the liver. We evaluated a change in patient model for end-stage liver disease (MELD)-Na and albumin level from the time of celiac disease diagnosis to six months later, after implementing a gluten-free diet. Methods A retrospective study was conducted from January 1, 2006, to June 30, 2018. Read More

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http://dx.doi.org/10.7759/cureus.8237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306642PMC

Immune checkpoint inhibitor-associated celiac disease.

J Immunother Cancer 2020 Jun;8(1)

Harvard Medical School, Boston, MA, USA

Background: Rare cases of immune checkpoint inhibitor (ICI)-associated celiac disease (ICI-CeD) have been reported, suggesting that disruption of tolerance mechanisms by ICIs can unmask celiac disease (CeD). This study aims to characterize the clinicopathological and immunophenotypic features of ICI-CeD in comparison to ICI-associated duodenitis (ICI-Duo) and usual CeD.

Methods: A medical and pathological records search between 2015 and 2019 identified eight cases of ICI-CeD, confirmed by tTG-IgA. Read More

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http://dx.doi.org/10.1136/jitc-2020-000958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319774PMC

Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity.

Nutrients 2020 Jun 19;12(6). Epub 2020 Jun 19.

Department of Morphology, Surgery and Experimental Medicine, St. Anna University Hospital, University of Ferrara, 44124 Cona, Italy.

Celiac disease (CD) and non-celiac gluten/wheat sensitivity (NCG/WS) are the two most frequent conditions belonging to gluten-related disorders (GRDs). Both these diseases are triggered and worsened by gluten proteins ingestion, although other components, such as amylase/trypsin inhibitors (ATI) and fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), seem to be involved in the NCG/WS onset. Therefore, the only effective treatment to date is the long-life adherence to a strictly gluten-free diet. Read More

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http://dx.doi.org/10.3390/nu12061832DOI Listing

Characterization of white and red sorghum flour and their potential use for production of extrudate crisps.

PLoS One 2020 23;15(6):e0234940. Epub 2020 Jun 23.

Department of Grain Science and Industry, Kansas State University, Manhattan, Kansas, United States of America.

In the human food industry, the wheat-free market sales have increased over the years due to awareness of wheat gluten allergy and celiac disease. Sorghum is a gluten-free grain with great potential to address shortcomings in this market. The aim of this study was to evaluate the milling process and flour quality of one white and one red sorghum varieties and evaluate extrusion as a potential process to produce sorghum crisps. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234940PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310728PMC

TUBB3 E410K syndrome: Case report and review of the clinical spectrum of TUBB3 mutations.

Am J Med Genet A 2020 Jun 23. Epub 2020 Jun 23.

Rare Diseases and Medical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS Rome, Rome, Italy.

The tubulinopathies refer to a wide range of brain malformations caused by mutations in one of the seven genes encoding different tubulin's isotypes. The β-tubulin isotype III (TUBB3) gene has a primary function in nervous system development and axon generation and maintenance, due to its neuron-specific expression pattern. A recurrent heterozygous mutation, c. Read More

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http://dx.doi.org/10.1002/ajmg.a.61719DOI Listing

Aqueous RAFT Synthesis of Low Molecular Weight Anionic Polymers for Determination of Structure/Binding Interactions with Gliadin.

Macromol Biosci 2020 Jun 22:e2000125. Epub 2020 Jun 22.

A. N. Bristol, B. P. Carpenter, A. N. Davis, L. K. Kemp, S. E. Morgan, School of Polymer Science and Engineering, 118 College Dr., #5050, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.

Gliadin, a component of gluten and a known epitope, is implicated in celiac disease (CeD) and results in an inflammatory response in CeD patients when consumed. Acrylamide-based polyelectrolytes are employed as models to determine the effect of molecular weight and pendent group on non-covalent interaction modes with gliadin in vitro. Poly(sodium 2-acrylamido-2-methylpropane sulfonate) and poly(sodium 3-methylpropyl-3-butanoate) are synthesized via aqueous reversible addition fragmentation chain transfer (aRAFT) polymerization and characterized by gel permeation chromatography-multiangle laser light scattering. Read More

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http://dx.doi.org/10.1002/mabi.202000125DOI Listing

Multiple Autoimmune Syndrome: An Unusual Combination of Autoimmune Disorders.

Rev Recent Clin Trials 2020 Jun 21. Epub 2020 Jun 21.

Department of Immunology & Molecular biology, Sindh Institute of Urology and Transplantation, Karachi. Pakistan.

Background: Autoimmune diseases are multifactorial with environmental and heritable factors. Autoimmunity reflects an altered immune status therefore presence of more than one disorder is not uncommon. Coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS). Read More

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http://dx.doi.org/10.2174/1574887115666200621184110DOI Listing

Patient and Physician Factors Associated with Adenoma and Sessile Serrated Lesion Detection Rates.

Dig Dis Sci 2020 Jun 20. Epub 2020 Jun 20.

Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, 177 Fort Washington Avenue, New York, NY, 10032, USA.

Background And Aims: Sessile serrated lesions (SSLs) have been increasingly recognized as precursors to colorectal cancer. Unlike adenoma detection rate (ADR), there is currently no agreed-upon benchmark for SSL detection rate (SSLDR), and data on factors that impact SSL detection are limited. We aimed to identify patient, endoscopist, and procedural factors associated with SSL and adenoma detection. Read More

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http://dx.doi.org/10.1007/s10620-020-06419-8DOI Listing

Hyposplenism, Hashimoto's Autoimmune Thyroiditis and Overlap Syndrome (Celiac Disease and Autoimmune Hepatitis Type 1).

Am J Med Sci 2020 Apr 25. Epub 2020 Apr 25.

"Carol Davila" University of Medicine and Pharmacy, "Sf. Ioan" Clinical Emergency Hospital, Gastroenterology Department, Bucharest, Romania.

Hyposplenism is associated with autoimmune diseases, inflammatory bowel disease, severe celiac disease, autoimmune thyroiditis, untreated HIV infection and chronic graft-versus-host disease. The aim of this study was to review the existing data on hyposplenism associated with celiac disease and Hashimoto's autoimmune thyroiditis. Our research was based on a clinical case concerning a 41-year-old female who presented with asthenia, fatigue, dyspepsia and chronic diarrhea. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.04.022DOI Listing

The Role of Bile Acids in Chronic Diarrhea.

Am J Gastroenterol 2020 Jun 11. Epub 2020 Jun 11.

Division of Gastroenterology and Hepatology, Department of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA.

Bile acids (BAs) are the central signals in enterohepatic communication, and they also integrate microbiota-derived signals into enterohepatic signaling. The tissue distribution and signaling pathways activated by BAs through natural receptors, farsenoid X receptor and G protein-coupled BA receptor 1 (GPBAR1, also known as Takeda G-coupled receptor 5), have led to a greater understanding of the mechanisms and potential therapeutic agents. BA diarrhea is most commonly encountered in ileal resection or disease, in idiopathic disorders (with presentation similar to functional diarrhea or irritable bowel syndrome with diarrhea), and in association with malabsorption such as chronic pancreatitis or celiac disease. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000696DOI Listing

Long-term Consequences of Undiagnosed Celiac Seropositivity.

Am J Gastroenterol 2020 Jun 16. Epub 2020 Jun 16.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Objective: Diagnosed celiac disease (CD) is associated with lymphoproliferative malignancy and gastrointestinal cancer, but little is known about the long-term consequences of undiagnosed CD. We aimed to investigate long-term consequences of undiagnosed CD for mortality and incidence of cancer and other chronic diseases.

Methods: We screened biobank serum samples for immunoglobulin (Ig) A and IgG tissue transglutaminase (TTG) and IgG deamidated gliadin peptide in a study of 8 population-based cohort studies comprising 16,776 participants examined during 1976-2012 and followed with >99% complete follow-up in Danish nationwide registries until December 31, 2017, regarding vital status and incidence of diseases. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000737DOI Listing

Gluten-Free Diet in IBD: Time for a Recommendation?

Mol Nutr Food Res 2020 Jun 19:e1901274. Epub 2020 Jun 19.

Multidisciplinary Center for Inflammatory Bowel Diseases, Division of Gastroenterology and Hepatology, University of North Carolina, 130 Mason Farm Rd 4151 Bioinformatics Buildg, Chapel Hill, NC, 27599-7080, USA.

Patients and providers alike are highly interested in identifying potentially useful dietary interventions in the management of inflammatory bowel diseases (IBD). This review examines the clinical associations of celiac disease (CeD), non-celiac gluten sensitivity (NCGS), and IBD with a focus on available data of the therapeutic efficacy of gluten-free diet (GFD) or low-gluten-containing diets in the therapy of IBD. There is a strong association between CeD and microscopic colitis, but the prevalence of CeD among IBD patients is similar to that of the general population. Read More

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http://dx.doi.org/10.1002/mnfr.201901274DOI Listing

DNA damage, oxidative stress, and inflammation in children with celiac disease.

Genet Mol Biol 2020 10;43(2):e20180390. Epub 2020 Jun 10.

Universidade Federal de Santa Catarina, Centro de Ciências de Saúde, Departamento de Análises Clínicas, Florianópolis, SC, Brazil.

The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide (NOx), thiobarbituric acid, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and DNA damage were evaluated in peripheral blood samples from 47 celiac disease patients and 31 controls. Patients with celiac disease presented higher levels of DNA damage in comparison to controls (p=0. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2018-0390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288666PMC

COVID-19 pandemic perception in adults with celiac disease: an impulse to implement the use of telemedicine.

Dig Liver Dis 2020 May 16. Epub 2020 May 16.

Celiac Center at Department of Medicine, Surgery, Dentistry, Scuola Medica Salernitana, University of Salerno, Italy. Electronic address:

Background: Coronavirus Disease 2019 (COVID-19) causes severe complications and deaths all over the world. COVID-19 also has indirect effects from the lockdown and the possible lack of food. We aimed to evaluate the perception of this in Celiac Disease (CeD) patients who require a lifelong gluten-free diet as a therapy. Read More

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http://dx.doi.org/10.1016/j.dld.2020.05.014DOI Listing

Dysphagia as a Presentation of Celiac Disease.

ACG Case Rep J 2020 Apr 7;7(4):e00359. Epub 2020 Apr 7.

Department of Pediatric Gastroenterology, Stony Brook Children's Hospital, Stony Brook, NY.

Dysphagia is an uncommon symptom for celiac disease (CD). Typically, patients with CD present with abdominal pain, diarrhea, steatorrhea, weight loss, growth failure, anemia, or fatigue. We report a case of dysphagia in a pediatric patient with negative celiac serologies and positive histologic findings suspicious for CD. Read More

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http://dx.doi.org/10.14309/crj.0000000000000359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224714PMC

Intestinal Anti-tissue Transglutaminase2 Autoantibodies: Pathogenic and Clinical Implications for Celiac Disease.

Front Nutr 2020 29;7:73. Epub 2020 May 29.

Department of Medical Translational Sciences and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy.

Celiac disease (CD) is a systemic disease that primarily affects the small intestine. The presence of anti-tissue transglutaminase 2 (anti-TG2) antibodies in the serum, as well as the presence of autoimmune phenomena, account for the inclusion of CD among autoimmune diseases. Anti-TG2 autoantibodies are produced at intestinal level, where they are deposited even before they appear in circulation. Read More

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http://dx.doi.org/10.3389/fnut.2020.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273338PMC

Impact of a gluten-free diet on patients with celiac disease, nonceliac gluten sensitivity, and asymptomatic controls. A need for healthier gluten-free foods.

Authors:
A Viscido G Latella

Rev Gastroenterol Mex 2020 Jun 13. Epub 2020 Jun 13.

Unidad de Gastroenterología, Departamento de Vida, Salud y Ciencias del Medio Ambiente, Universidad de L'Aquila, L'Aquila, Italia.

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http://dx.doi.org/10.1016/j.rgmx.2020.04.005DOI Listing

Allergenicity Assessment of Novel Food Proteins: What Should Be Improved?

Trends Biotechnol 2020 Jun 13. Epub 2020 Jun 13.

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Allergenicity prediction is one of the most challenging aspects in the safety assessment of foods derived from either biotechnology or novel food proteins. Here we present a bottom-up strategy that defines a priori the specific risk assessment (RA) needs based on a database appropriately built for such purposes. Read More

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http://dx.doi.org/10.1016/j.tibtech.2020.05.011DOI Listing

Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?

Nutrients 2020 Jun 12;12(6). Epub 2020 Jun 12.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on thyroid function. Thyroid and intestinal diseases prevalently coexist-Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the most common autoimmune thyroid diseases (AITD) and often co-occur with Celiac Disease (CD) and Non-celiac wheat sensitivity (NCWS). This can be explained by the damaged intestinal barrier and the following increase of intestinal permeability, allowing antigens to pass more easily and activate the immune system or cross-react with extraintestinal tissues, respectively. Read More

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http://dx.doi.org/10.3390/nu12061769DOI Listing

Development of the Dietitian Integrated Evaluation Tool for Gluten-free Diets (DIET-GFD).

Nutrition 2020 Mar 20;78:110819. Epub 2020 Mar 20.

St. Boniface Hospital, Winnipeg, Manitoba, Canada; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Objectives: Celiac disease (CD) treatment involves a gluten-free diet (GFD). There is no standardized tool for dietitians to objectively grade GFD adherence. This study aimed to develop a standardized tool for dietitians to evaluate and communicate GFD adherence. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110819DOI Listing

Atopic dermatitis is associated with dermatitis herpetiformis and celiac disease in children.

J Invest Dermatol 2020 Jun 12. Epub 2020 Jun 12.

PEDEGO Research Unit, University of Oulu; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1016/j.jid.2020.05.091DOI Listing