24,054 results match your criteria Celiac Sprue


Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019
2.998 Impact Factor

Persistent Economic Burden of the Gluten Free Diet.

Nutrients 2019 Feb 14;11(2). Epub 2019 Feb 14.

Department of Medicine, Celiac Disease Center, Columbia University Medical Center, Harkness Pavilion, 180 Fort Washington Avenue, New York, NY 10032, USA.

Gluten free (GF) products have been reported to be more expensive and less available than their gluten containing counterparts. We examined the current U.S. Read More

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http://dx.doi.org/10.3390/nu11020399DOI Listing
February 2019

Role of Front-of-Package Gluten-Free Product Labeling in a Pair-Matched Study in Women with and without Celiac Disease on a Gluten-Free Diet.

Nutrients 2019 Feb 14;11(2). Epub 2019 Feb 14.

Department of Organization and Consumption Economics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (SGGW⁻WULS), 159C Nowoursynowska Street, 02⁻776 Warsaw, Poland.

Gluten-free (GF) product labeling is one of the most important determinants of food product choices by patients with celiac disease, due to the need for following a GF diet. The aim of this study was to assess the role of front-of-package GF product labeling in pair-matched celiac and non-celiac women on a GF diet in a choice experiment (CE). In subgroups of celiac ( = 77) and non-celiac pair-matched respondents on a GF diet, but with no gluten-related diseases diagnosed ( = 77), the influence of front-of package labeling of GF bread on the choice of products was assessed. Read More

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http://dx.doi.org/10.3390/nu11020398DOI Listing
February 2019

Long-Term Outcome of Potential Celiac Disease in Genetically at-Risk Children: The Prospective CELIPREV Cohort Study.

J Clin Med 2019 Feb 5;8(2). Epub 2019 Feb 5.

Department of Pediatrics, Marche Polytechnic University, 60123 Ancona, Italy.

Background: The long-term outcome of potential celiac disease (CD) is still a debated issue. We aimed to evaluate the progression of potential CD versus overt CD after 10-years of follow-up in a cohort of children genetically predisposed to CD.

Methods: The CELIPREV study is prospectively following from birth 553 children with CD-predisposing HLA genes. Read More

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http://dx.doi.org/10.3390/jcm8020186DOI Listing
February 2019

Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis.

PLoS One 2019 14;14(2):e0212329. Epub 2019 Feb 14.

Division of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.

Background And Aims: Experimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD.

Methods: We searched seven medical databases for studies discussing HLA-DQB1 gene dose in CD and various disease characteristics, such as clinical presentation, histology, age at diagnosis, and comorbidities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212329PLOS
February 2019

p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine.

Front Immunol 2019 30;10:31. Epub 2019 Jan 30.

Instituto de Estudios Inmunológicos y Fisiopatológicos (CONICET), Universidad Nacional de La Plata, La Plata, Argentina.

Celiac disease (CD) is a chronic enteropathy elicited by a Th1 response to gluten peptides in the small intestine of genetically susceptible individuals. However, it remains unclear what drives the induction of inflammatory responses of this kind against harmless antigens in food. In a recent work, we have shown that the p31-43 peptide (p31-43) from α-gliadin can induce an innate immune response in the intestine and that this may initiate pathological adaptive immunity. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363691PMC
January 2019

Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review.

Nutrients 2019 Feb 12;11(2). Epub 2019 Feb 12.

Royal Hallamshire Hospital and University of Sheffield, Sheffield S10 2RX, UK.

Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. Read More

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http://www.mdpi.com/2072-6643/11/2/380
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http://dx.doi.org/10.3390/nu11020380DOI Listing
February 2019
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The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions.

Nutrients 2019 Feb 12;11(2). Epub 2019 Feb 12.

Human Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

The gut microbiota performs several essential protective, structural, and metabolic functions for host health. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and between the microorganisms and the host. The gut microbiota composition may be affected by external factors, among them diet habits may be considered most important. Read More

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http://dx.doi.org/10.3390/nu11020373DOI Listing
February 2019

Overlap of Characteristic Serological Antibodies in Rheumatoid Arthritis and Wheat-Related Disorders.

Dis Markers 2019 10;2019:4089178. Epub 2019 Jan 10.

Vibrant Sciences, LLC., San Carlos, CA, USA.

Background And Aims: Rheumatoid arthritis (RA) and celiac disease (CD) are members of the autoimmune disease family while they have been shown to share multiple aspects in epidemiology and clinical manifestations. The aim of this study was to assess the presence of wheat protein antibodies in RA seropositive subjects and the presence of RA diagnostic markers in subjects with seropositive wheat-related disorders including CD.

Methods: Serum samples were collected from 844 subjects with joint pain and/or gastrointestinal symptoms and tested by a CD panel (anti-tTG and anti-DGP), a Wheat Zoomer (WZ) antibody panel (IgG/IgA to 14 wheat proteins), and a RA panel (anti-CCP and anti-RF). Read More

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https://www.hindawi.com/journals/dm/2019/4089178/
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http://dx.doi.org/10.1155/2019/4089178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348907PMC
January 2019
2 Reads

Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn's disease.

J Crohns Colitis 2019 Feb 7. Epub 2019 Feb 7.

Institute for Biotechnology, Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Universitätsplatz, Senftenberg, Germany.

Objective: There is an increasing incidence of inflammatory bowel disease (IBD). Autoimmune responses partake in the pathophysiology of IBD, however, its underlying pathways and target antigens are not yet fully elucidated.

Methods: Autoantigenic targets in IBD were identified after separation of whole cell proteins isolated from neutrophils using two dimensional electrophoresis and Matrix Assisted Laser Desorption Ionization - Time of Flight Mass Spectrometry (MALDI-TOF-MS) based protein identification of the spots that displayed Western blotting signals with anti-neutrophil cytoplasmic antibody (ANCA)-positive sera. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz012DOI Listing
February 2019
1 Read

HLA-DQ Genotyping, Duodenal Histology, and Response to Exclusion Diet in Autistic Children With Gastrointestinal Symptoms.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastroenterology and Hepatology, Città Della Salute e Della Scienza di Torino Hospital.

Objectives: A correlation between autism spectrum disorders (ASDs) and gastrointestinal (GI) problems, and a possible link between gluten consumption and ASD have been increasingly reported. Gluten/casein-free diet (GCFD) is often undertaken, with conflicting results. This study aimed at evaluating the distribution of human leukocyte antigen (HLA)-DQ2/DQ8 typing among patients with ASD with GI symptoms, together with its correlation with duodenal histology and response to GCFD. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002293DOI Listing
February 2019
1 Read

Magnetically Controlled Capsule Endoscopy in Children: A Single Center, Retrospective Cohort Study.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Objective: Capsule endoscopy (CE) is a noninvasive diagnostic tool for the digestive tract. We aim to investigate the feasibility and safety of newly-developed magnetically controlled capsule endoscopy (MCE) in children.

Methods: A total of 129 children who underwent MCE in Shanghai Children's Hospital were retrospectively recruited between March 2016 and August 2018. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002292DOI Listing
February 2019
2 Reads

A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

Am J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID.

Methods: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000140DOI Listing
February 2019
1 Read

Demystifying autoimmune small bowel enteropathy.

Curr Opin Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Purpose Of Review: We reviewed the current 'state of the art' on autoimmune enteropathy and small-bowel mucosal atrophy, with the aim of supporting clinicians in a frequently challenging diagnosis through different therapeutic options and prognosis.

Recent Findings: The diagnosis of small-bowel diseases has radically changed over the last 10 years. The possibility to 'easily' obtain bioptic samples from the jejunum and ileum by means of the enteroscopic techniques (particularly, device-assisted enteroscopy) and the novel cross-sectional imaging studies have opened the window to new insights on intestinal disorders. Read More

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http://Insights.ovid.com/crossref?an=00001574-900000000-9922
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http://dx.doi.org/10.1097/MOG.0000000000000515DOI Listing
February 2019
1 Read

Celiac crisis, a rare occurrence in adult celiac disease: A systematic review.

World J Clin Cases 2019 Feb;7(3):311-319

Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.

Background: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children.

Aim: To perform a review of CC cases reported in adult CD patients. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i3.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369385PMC
February 2019
1 Read

Technological Quality and Nutritional Value of Two Durum Wheat Varieties Depend on Both Genetic and Environmental Factors.

J Agric Food Chem 2019 Feb 19. Epub 2019 Feb 19.

Interdepartmental Center SITEIA.PARMA , University of Parma , Parco Area delle Scienze , 43124 Parma , Italy.

Durum wheat ( Triticum turgidum L. subsp. durum (Desf. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.8b06621
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http://dx.doi.org/10.1021/acs.jafc.8b06621DOI Listing
February 2019
2 Reads

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.

Cell 2019 Feb 5. Epub 2019 Feb 5.

Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA. Electronic address:

Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic inflammation. In the setting of celiac disease (CeD), where exposure to dietary antigen can be controlled, gluten-induced inflammation triggered a profound depletion of naturally occurring Vγ4/Vδ1 intraepithelial lymphocytes (IELs) with innate cytolytic properties and specificity for the butyrophilin-like (BTNL) molecules BTNL3/BTNL8. Creation of a new niche with reduced expression of BTNL8 and loss of Vγ4/Vδ1 IELs was accompanied by the expansion of gluten-sensitive, interferon-γ-producing Vδ1 IELs bearing T cell receptors (TCRs) with a shared non-germline-encoded motif that failed to recognize BTNL3/BTNL8. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183165
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http://dx.doi.org/10.1016/j.cell.2018.12.039DOI Listing
February 2019
2 Reads

Celiac Disease: Beyond Genetic Susceptibility and Gluten. A Narrative Review.

Ann Med 2019 Feb 9:1-47. Epub 2019 Feb 9.

a Department of Medical, Surgical and Experimental Sciences , University of Sassari , Sassari , Italy.

Context: Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals. However, only a small proportion of subjects harbouring CD-related genetic risk develop the disease. Among the environmental factors that may influence CD risk, pre- and perinatal factors, delivery methods, parental lifestyle, infant feeding practices, seasonality, dietary factors, drug use, childhood infections and variability in gut microbiota are those most widely studied regarding the risk to develop CD. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2019.1
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http://dx.doi.org/10.1080/07853890.2019.1569254DOI Listing
February 2019
2 Reads

Prevalence of celiac disease in a large cohort of young patients with type 1 diabetes.

Pediatr Diabetes 2019 Feb 8. Epub 2019 Feb 8.

Instituto da Criança com Diabetes, Grupo Hospitalar Conceição - Ministério da Saúde.

Background: Serological screening for celiac disease (CD) allows the identification of individuals genetically predisposed, as type 1 diabetes mellitus (T1DM). However, the diagnosis is confirmed by intestinal biopsy. The aim was to determine the prevalence of immunoglobulin-A anti-tissue transglutaminase antibodies (IgA-tTG) and CD in a large cohort of young T1DM patients. Read More

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http://doi.wiley.com/10.1111/pedi.12827
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http://dx.doi.org/10.1111/pedi.12827DOI Listing
February 2019
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Defective proteostasis in celiac disease as a new therapeutic target.

Cell Death Dis 2019 Feb 8;10(2):114. Epub 2019 Feb 8.

Equipe11 labellisée Ligue Nationale contrele Cancer, Centre de Recherche des Cordeliers, Paris, France.

Cystic fibrosis (CF) is a disease caused by loss-of-function mutations affecting the CF transmembrane conductance regulator (CFTR), a chloride channel. Recent evidence indicates that CFTR is inhibited by a gluten/gliadin-derived peptide (P31-43), causing an acquired state of CFTR inhibition within the gut that contributes to the pathogenesis of celiac disease (CD). Of note, CFTR inhibition does not only cause intra- and extracellular ion imbalances but also affects proteostasis by activating transglutaminase-2 (TGM2) and by disabling autophagy. Read More

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http://dx.doi.org/10.1038/s41419-019-1392-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368542PMC
February 2019
1 Read

Insights into Cardiovascular Risk and Nutritional Status in Subjects with Wheat-related Disorders.

Biomarkers 2019 Feb 8:1-11. Epub 2019 Feb 8.

b Vibrant Sciences LLC. , San Carlos , CA , USA.

Objective: Wheat-related disorders are a spectrum of disorders associated with different autoimmune and non-autoimmune diseases. However, it is unclear whether these wheat-related disorders lead to adverse health effects such as cardiovascular risk, nutritional deficiencies etc. The objective of the study was to explore the lipid profiles and the nutritional status of subjects with wheat-related disorders to understand the potential threat by wheat on cardiovascular risk and nutritional deficiency. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1578829DOI Listing
February 2019
1 Read

Aneurysms of Pancreaticoduodenal Artery due to Median Arcuate Ligament Syndrome, Treated by Open Surgery and Laparoscopic Surgery.

Case Rep Surg 2019 13;2019:1795653. Epub 2019 Jan 13.

Department of Surgery, Juntendo Shizuoka Hospital, Shizuoka, Japan.

Introduction: There are many possible causes of an abdominal visceral aneurysm, including the obstruction of the celiac artery by the median arcuate ligament (MAL). We report two cases of an aneurysm of the pancreaticoduodenal artery due to MAL syndrome that we treated surgically.

Case Presentation: Case 1: a 66-year-old Japanese woman was diagnosed with a rupture of an aneurysm of the inferior pancreaticoduodenal artery. Read More

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http://dx.doi.org/10.1155/2019/1795653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348794PMC
January 2019
1 Read

Scouting for Naturally Low-Toxicity Wheat Genotypes by a Multidisciplinary Approach.

Sci Rep 2019 Feb 7;9(1):1646. Epub 2019 Feb 7.

Institute of Sciences of Food Production, National Research Council of Italy (ISPA-CNR), via Giovanni Amendola, 122/O - 70126, Bari, Italy.

Over the last years, great efforts have been devoted to develop effective gluten detoxification strategies with a consequent detrimental alteration of the technological properties as well. Obtaining low-gluten products without affecting the rheological properties of wheat could still be considered a new challenge to face. In this investigation, we presented a comprehensive characterization of durum wheat genotypes aimed at identifying low gluten ones, which combine the potential lower toxicity/immunogenicity with conserved yield and rheological properties to encompass the perspective usability for bread or pasta making. Read More

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http://www.nature.com/articles/s41598-018-36845-8
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http://dx.doi.org/10.1038/s41598-018-36845-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367382PMC
February 2019
1 Read

Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review.

Nutr J 2019 Feb 7;18(1). Epub 2019 Feb 7.

Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. Read More

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http://dx.doi.org/10.1186/s12937-019-0434-6DOI Listing
February 2019
1 Read

Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease.

Med Princ Pract 2019 Feb 6. Epub 2019 Feb 6.

Objective: Recent studies have demonstrated that angiogenesis is impaired in patients with celiac disease (CD). In this study, we evaluated the levels of the novel anti-angiogenic factor pigment epithelium-derived factor (PEDF) in CD patients.

Methods: 84 patients were included in the study; 71 patients with celiac disease and 13 healthy controls. Read More

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https://www.karger.com/Article/FullText/497612
Publisher Site
http://dx.doi.org/10.1159/000497612DOI Listing
February 2019
4 Reads

Deamidated gliadin peptide in pediatric patients with moderately increased tissue transglutaminase; does it help?

Clin Chim Acta 2019 Feb 3;492:20-22. Epub 2019 Feb 3.

Department of Laboratories, Seattle Children's Hospital, United States; Department of Anatomic Pathology, University of Washington, United States.

Background: Deamidated gliadin peptide (DGP) is a relatively new serologic assay used in diagnosis and monitoring of celiac disease. DGP IgG is recommended by some in pediatric patients <2 y. Use in other pediatric populations is not well established. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.002DOI Listing
February 2019

[Characterization of celiac disease in chilean public hospitals].

Rev Chil Pediatr 2018 Dec;89(6):709-717

Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Chile.

Introduction: The worldwide prevalence of celiac disease (CD) is ~1% of the population. In Chile, the National Health Survey 2009-2010 showed a serological prevalence in individuals older than 15 years of 0.76% (IgA-tTG2), which corresponded in Concepción to 0. Read More

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http://dx.doi.org/10.4067/S0370-41062018005001001DOI Listing
December 2018
1 Read

An integrated, accurate, rapid, and economical handheld consumer gluten detector.

Food Chem 2019 Mar 1;275:446-456. Epub 2018 Sep 1.

Nima Labs, Inc., 450 Alabama St., San Francisco, CA 94110, United States.

Celiac disease, characterized by autoimmune reactions to dietary gluten, affects up to 3 million in the US and approximately 0.5%-1% globally. A strict, lifelong gluten-free diet is the only treatment. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.08.117DOI Listing
March 2019
2 Reads

Gluten in Celiac Disease-More or Less?

Rambam Maimonides Med J 2019 Jan 28;10(1). Epub 2019 Jan 28.

Pediatric Gastroenterology & Nutrition Institute, Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel.

To date, the only known effective treatment for celiac disease is a strict gluten-free diet for life. We reviewed the literature to evaluate the upper limit for gluten content in food, which would be safe for patients with celiac disease. Patients with celiac disease should limit their daily gluten intake to no more than 10-50 mg. Read More

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http://dx.doi.org/10.5041/RMMJ.10360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363368PMC
January 2019

The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region.

Sci Rep 2019 Feb 4;9(1):1298. Epub 2019 Feb 4.

Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Biocruces-Bizkaia Health Research Institute, Leioa, Basque Country, 48940, Spain.

The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD could be driven by other layers of genomic information independent from sequence variation, such as DNA methylation, and it is possible that allele-specific methylation explains part of the SNP associations. Since the DNA methylation landscape is expected to be different among cell types, we analyzed the methylome of the epithelial and immune cell populations of duodenal biopsies in CD patients and controls separately. Read More

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http://www.nature.com/articles/s41598-018-37746-6
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http://dx.doi.org/10.1038/s41598-018-37746-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362130PMC
February 2019
4 Reads

Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait.

Nutrients 2019 Feb 1;11(2). Epub 2019 Feb 1.

Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33520 Tampere, Finland.

Celiac disease patients may suffer from a number of extra-intestinal diseases related to long-term gluten ingestion. The diagnosis of celiac disease is based on the presence of a manifest small intestinal mucosal lesion. Individuals with a normal biopsy but an increased risk of developing celiac disease are referred to as potential celiac disease patients. Read More

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http://dx.doi.org/10.3390/nu11020320DOI Listing
February 2019
1 Read

Optimization of hot-air drying conditions for cassava flour for its application in gluten-free pasta formulation.

Food Sci Technol Int 2019 Feb 2:1082013219828269. Epub 2019 Feb 2.

1 BIOALI Research Group, Department of Food, Faculty of Pharmaceutical Sciences and Food, Universidad de Antioquia, Medellín, Colombia.

The design and development of gluten-free foods requires a comprehensive understanding of the behavior of the raw materials to attain the same cooking and nutritional quality as gluten-based food. The objective of this study was to determine the optimal hot-air drying conditions for elaboration of cassava flour to be used in a gluten-free pasta formulation. The results showed that the operational conditions to minimize the hot-air drying time (57 min) to produce cassava flour with higher water holding capacity was 57 ℃ at 3 m/s. Read More

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http://dx.doi.org/10.1177/1082013219828269DOI Listing
February 2019

New Developments in Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):xv-xvi. Epub 2018 Dec 13.

Celiac Disease Center at Columbia University, 180 Fort Washington Avenue, Suite 936, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.10.001DOI Listing

Celiac Disease, Gluten-Free, and Today's Fashionista.

Authors:
Alan L Buchman

Gastroenterol Clin North Am 2019 03 13;48(1):xiii-xiv. Epub 2018 Dec 13.

Intestinal Rehabilitation and Transplant Center, Department of Surgery, College of Medicine, The University of Illinois at Chicago, 840 South Wood Street, Suite 402 Clinical Sciences Building, MC 958 Chicago, IL 60612, USA; Health Care Services Corporation, 300 E. Randolph Street, Chicago, IL 60601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2018.10.002DOI Listing

(Outcome) Measure for (Intervention) Measures: A Guide to Choosing the Appropriate Noninvasive Clinical Outcome Measure for Intervention Studies in Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):85-99. Epub 2018 Dec 13.

Harvard Celiac Disease Research Program, Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA; Gastroenterology Therapeutic Area Research and Development, Takeda Pharmaceuticals, 40 Landsdowne Street, Boston, MA 02139, USA.

There is an unmet need for diagnostic and treatment interventions for celiac disease. Both clinical trials and real-world studies require careful selection of clinical outcome measures. Often, neither serology nor histology is an appropriate primary outcome. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368393PMC

Capsule Endoscopy and Enteroscopy in Celiac Disease.

Gastroenterol Clin North Am 2019 03 14;48(1):73-84. Epub 2018 Dec 14.

The University of Chicago, 5841 South Maryland Avenue, MC 4080 S401, Chicago, IL 60637, USA.

Celiac disease predominantly involves the proximal small bowel, but villus atrophy can be patchy, spare the duodenum, and be present more distally. Video capsule endoscopy is more sensitive than standard endoscopy to detect villus atrophy, and can define extent of disease, though it cannot obtain biopsies. Duodenal biopsy is the gold standard for diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183008
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http://dx.doi.org/10.1016/j.gtc.2018.09.005DOI Listing
March 2019
3 Reads

Nutritional Considerations of the Gluten-Free Diet.

Gastroenterol Clin North Am 2019 03 14;48(1):53-72. Epub 2018 Dec 14.

Division of Gastroenterology, Hepatology and Nutrition, Celiac Center, Boston Children's Hospital, 330 Longwood Avenue, Boston, MA 02215, USA.

Celiac disease (CD) is an autoimmune-related disease causing inflammation in the small intestine triggered by the ingestion of gluten in the diet. The gluten-free diet (GFD) is the only treatment. Nutritional deficiencies of macronutrients and micronutrients are frequently found in untreated or newly diagnosed CD. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.002DOI Listing

Biopsy Diagnosis of Celiac Disease: The Pathologist's Perspective in Light of Recent Advances.

Gastroenterol Clin North Am 2019 03 14;48(1):39-51. Epub 2018 Dec 14.

Columbia University, New York Presbyterian Hospital, 622 West 168th Street, VC14-228, New York, NY 10032, USA.

Celiac disease is a common immune-mediated disorder that occurs in individuals with permissive genetics (HLA-DQ2/DQ8 genotype) following exposure to certain wheat proteins. The histopathologic manifestations of small intestinal mucosal injury (villus atrophy, crypt hyperplasia, and intraepithelial lymphocytosis) are well recognized. However, these findings are not specific for celiac disease, because they are observed in other small intestinal disorders. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.003DOI Listing
March 2019
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Celiac Disease: Clinical Features and Diagnosis.

Gastroenterol Clin North Am 2019 03 13;48(1):19-37. Epub 2018 Dec 13.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. Electronic address:

The presentation in celiac disease is shifting from the classical malabsorptive presentation to more nonclassical presentations, requiring clinicians to maintain a high level of suspicion for the disease and to be aware of the possible extraintestinal manifestations. The diagnosis of celiac disease is guided by initial screening with serology, followed by confirmation with an upper endoscopy and small intestinal biopsy. In some pediatric cases, biopsy may be avoided. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183007
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http://dx.doi.org/10.1016/j.gtc.2018.09.001DOI Listing
March 2019
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Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations.

Gastroenterol Clin North Am 2019 03 13;48(1):165-182. Epub 2018 Dec 13.

Department of Medicine, Columbia University Medical Center, 1130 Saint Nicholas Avenue, New York, NY 10032, USA; Celiac Disease Center, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY 10032, USA; Institute of Human Nutrition, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA. Electronic address:

Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364564PMC
March 2019
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Nondietary Therapies for Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):145-163. Epub 2018 Dec 13.

Division of Pediatric Gastroenterology and Nutrition, Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, 175 Cambridge Street, CPZS - 574, Boston, MA 02114, USA; Celiac Research Program, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address:

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten. Gluten-free diets can be challenging because of their restrictive nature, inadvertent cross-contaminations, and the high cost of gluten-free food. Novel nondietary therapies are at the preclinical stage, clinical trial phase, or have already been developed for other indications and are now being applied to CD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183008
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http://dx.doi.org/10.1016/j.gtc.2018.09.011DOI Listing
March 2019
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Refractory Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):137-144. Epub 2018 Dec 13.

Paris Descartes University, 15 rue de l'Ecole de Médecine, Paris 75006, France; Gastroenterology Department, Hôpital Européen Georges Pompidou, APHP, 20 rue Leblanc, Paris 75015, France; UMR1163 Institute Imagine, 24 Boulevard du Montparnasse, Paris 75015, France.

Refractory celiac disease (RCD) refers to persistence of malnutrition and intestinal villous atrophy for more than 1 to 2 years despite strict gluten-free diet in patients with celiac disease. Diagnosis remains difficult and impacts treatment and follow-up. RCD has been subdivided into 2 subgroups according to the normal (RCDI) or abnormal phenotype of intraepithelial lymphocytes (IELs) (RCDII). Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.010DOI Listing

Follow-up of Celiac Disease.

Gastroenterol Clin North Am 2019 03 14;48(1):127-136. Epub 2018 Dec 14.

Hospital de Gastroenterología Dr. C. Bonorino Udaondo, Av. Caseros 2061, Buenos Aires 1236, Argentina.

Currently, the only effective treatment for celiac disease is complete removal of gluten from the diet. However, patients need to follow a strict gluten-free diet that results in symptomatic, serologic, and histologic remission in most patients. Histologic remission is usually complete in children, but recovery is slower and more frequently incomplete in adults. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183008
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http://dx.doi.org/10.1016/j.gtc.2018.09.009DOI Listing
March 2019
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The Microbiome in Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):115-126. Epub 2018 Dec 13.

Digestive and Liver Diseases, Columbia University, 180 Fort Washington, New York, NY 10032, USA. Electronic address:

The healthy microbiome is necessary for normal immune development in the gut. Alterations in the microbial makeup after a critical window increase the risk of autoimmunity, including celiac disease. Although this dysbiosis has been described in adult and pediatric patients, factors leading to dysbiosis are still being elucidated. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.008DOI Listing

Celiac Disease in Asia.

Gastroenterol Clin North Am 2019 03 13;48(1):101-113. Epub 2018 Dec 13.

Department of Pediatrics, Center for Celiac Research, Università Politecnica delle Marche, Piazzale Martelli Raffaele, 8, Ancona, Ancona 60121, Italy; Division of Pediatric Gastroenterology, Massachussets General Hospital, Boston, MA 33131, USA.

Celiac disease, once thought to be very uncommon in Asia, is now emerging in many Asian countries. Although the absolute number of patients with celiac disease at present is not very high, this number is expected to increase markedly over the next few years/decades owing to increasing awareness. It is now that the medical community across the Asia should define the extent of the problem and prepare to handle the impending epidemic of celiac disease in Asia. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.007DOI Listing
March 2019
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Epidemiology of Celiac Disease.

Gastroenterol Clin North Am 2019 03 13;48(1):1-18. Epub 2018 Dec 13.

Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; University of Southern Denmark, Odense, Denmark.

Celiac disease is a common, chronic inflammatory disorder of the small intestine triggered by exposure to gluten in individuals with certain genetic types. This disorder affects people of any age or gender. Although often thought to be European in origin, it is now global in extent. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.09.004DOI Listing

Truth lies below: A case report and literature review of typical appearing polyps yet with an atypical diagnosis.

World J Gastrointest Endosc 2019 Jan;11(1):54-60

Department of Internal Medicine, Division of Gastroenterology, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, MI 48075, United States.

Background: Enteropathy associated T-cell lymphoma (EATL) is a rare form of peripheral T-cell lymphoma and makes up less than 5% of gastrointestinal lymphomas. EATL can be divided into type 1 which is associated with celiac disease, and monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formally type 2, which is not associated with celiac disease.

Case Summary: We present a 60-year-old African American female, without celiac disease, who presented with abdominal pain, diarrhea, and 30 lb. Read More

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http://dx.doi.org/10.4253/wjge.v11.i1.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354114PMC
January 2019
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Preteen children's health related quality of life in Sweden: changes over time and disparities between different sociodemographic groups.

BMC Public Health 2019 Jan 31;19(1):139. Epub 2019 Jan 31.

Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden.

Background: Assessing disparities in health-related quality of Life (HRQoL) is important as a part of health-related disparities in the society. The aim of this study was to explore HRQoL among 12-year-olds in Sweden in terms of differences between years 2005 and 2009 and disparities related to sociodemographic background.

Methods: During the school years 2005 and 2009, a total of 18,325 sixth grade students in Sweden were invited to a celiac disease screening study; 13,279 agreed to participate. Read More

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http://dx.doi.org/10.1186/s12889-019-6429-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357483PMC
January 2019

Is it necessary to use capsular endoscopy to diagnose celiac disease?

Ter Arkh 2018 Apr;90(4):8-11

A.S. Loginov Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia.

Aim: To clarify the indications for capsular endoscopy (CE) in patients with celiac disease.

Materials And Methods: The study included 10 patients with celiac disease (6 women, 4 men) aged 22 to 69 years. The median age was 42. Read More

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http://dx.doi.org/10.26442/terarkh20189048-11DOI Listing

Reproductive disorders, osteoporosis and secondary hyperparathyroidism with celiac disease.

Ter Arkh 2018 Nov;90(10):89-93

A.S. Loginov Moscow Clinical Scientific Practical Center of the Moscow Healthcare Department, Moscow, Russia.

A clinical observation of a patient with celiac disease, aged 23, with severe form of osteoporosis, accompanied by atraumatic fractures bones, lameness, late onset of menstruation and pathology of pregnancy is described. It is emphasized that only a timely diagnosis celiac disease and timely prescribed treatment make it possible to avoid severe complications. Read More

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http://dx.doi.org/10.26442/terarkh2018901089-93DOI Listing
November 2018
4 Reads